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Profile

Richard Castillo

  • Department of Radiation Oncology
    Professor
  • (404) 778-7339
  • richard.castillo@emory.edu
  • The Deformable Image Registration Laboratory
Head shot of Richard Castillo

Overview

An ABR board certified medical physicist, Dr. Castillo has expertise in image-guided, and adaptive radiation therapy, the use of deformable image registration in medical image analysis, and quantitative methods for lung function imaging from CT.

Dr. Castillo is a professor of medical physics in the Department of Radiation Oncology at Emory University School of Medicine. He serves as assistant dean of equity, engagement and belonging in the Office of Equity and Inclusion, driving progress in the office's strategic priorities, primarily growing the innovation and discovery portfolio.

Dr. Castillo has previously served as principal investigator for an NIH Research Scientist Development Award (K01), and currently is co-investigator on an ongoing clinical trial (NCT02528942) prospectively evaluating the safety, feasibility, and preliminary efficacy of 4DCT-ventilation functional avoidance planning. As part of his PhD research, Dr. Castillo founded The Deformable Image Registration Laboratory website in 2009, and continues to maintain and support its function as a public repository for reference image data and image analysis software for quantitative clinical evaluation of deformable image registration.

Dr. Castillo is a Fellow and an active member of the American Association of Physicists in Medicine (AAPM), and currently sits on the AAPM's Diversity and Inclusion subcommittee. He also actively serves as associate senior editor for the International Journal of Radiation Oncology, Biology, Physics.

Academic Appointment

  • Professor, Department of Radiation Oncology, Emory University School of Medicine

Education

Degrees

  • PhD from University of Texas Graduate School of Biomedical Sciences
  • MS from University of Texas Graduate School of Biomedical Sciences

Research

Focus

  • Deformable image registration in medical image analysis

    Dr. Castillo's research is largely focused on the use of deformable image registration in medical image analysis, for purposes of guiding personalized delivery and treatment adaptation in radiotherapy of thoracic malignancies.

Publications

  • Comprehensive clinical evaluation of novel 4DCT-based lung function imaging methods.
    J Appl Clin Med Phys Page(s): e70088
    04/08/2025 Authors: Golkar E; Neupane T; Wilson L; Kwak J; Castillo R; Castillo E; Vinogradskiy Y
  • Patient-Reported Outcomes: Comparing Functional Avoidance and Standard Thoracic Radiation Therapy in Lung Cancer.
    JCO Clin Cancer Inform Volume: 9 Page(s): e2400202
    02/01/2025 Authors: Poiset SJ; Lombardo J; Castillo E; Castillo R; Jones B; Miften M; Kavanagh B; Dicker AP; Boyle C; Simone NL
  • Perfusion estimation from dynamic non-contrast computed tomography using self-supervised learning and a physics-inspired U-net transformer architecture.
    Int J Comput Assist Radiol Surg
    01/20/2025 Authors: Liu Y-K; Cisneros J; Nair G; Stevens C; Castillo R; Vinogradskiy Y; Castillo E
  • TriSwinUNETR lobe segmentation model for computing DIR-free CT-ventilation.
    Front Oncol Volume: 15 Page(s): 1475133
    01/01/2025 Authors: Nomura GRO; Luong AT; Prakash A; Alemand A; Bhowmick T; Ali A; Ren J; Rehani B; Nair G; Castillo R
  • Prospective Trial of Functional Lung Avoidance Radiation Therapy for Lung Cancer: Quality of Life Report.
    Int J Radiat Oncol Biol Phys Volume: 120 Page(s): 593 - 602
    10/01/2024 Authors: Lombardo J; Castillo E; Castillo R; Miller R; Jones B; Miften M; Kavanagh B; Dicker A; Boyle C; Leiby B
  • Women in the Medical Physics Workforce: Insights from Membership Trends of the American Association of Physicists in Medicine, 1993 to 2023.
    Int J Radiat Oncol Biol Phys Volume: 119 Page(s): 1336 - 1343
    08/01/2024 Authors: Rankin J; Bedrava J; Covington E; Johnson JL; Pollard-Larkin J; Schipper MJ; Castillo R; Woodward M; Xing Y-H; Paradis KC
  • Systematic Evaluation of the Impact of Lung Segmentation Methods on 4-Dimensional Computed Tomography Ventilation Imaging Using a Large Patient Database.
    Int J Radiat Oncol Biol Phys Volume: 118 Page(s): 242 - 252
    01/01/2024 Authors: Chen Y; Pahlavian SH; Jacobs P; Neupane T; Forghani-Arani F; Castillo E; Castillo R; Vinogradskiy Y
  • Evaluation of variables predicting PFT changes for lung cancer patients treated on a prospective 4DCT-ventilation functional avoidance clinical trial.
    Radiother Oncol Volume: 187 Page(s): 109821
    10/01/2023 Authors: Ghassemi N; Castillo R; Castillo E; Jones BL; Miften M; Kavanagh B; Werner-Wasik M; Miller R; Barta JA; Grills I
  • Cardiac metabolic changes on 18 F-positron emission tomography after thoracic radiotherapy predict for overall survival in esophageal cancer patients.
    J Appl Clin Med Phys Volume: 24 Page(s): e13552
    09/01/2023 Authors: Zakem SJ; Jones B; Castillo R; Castillo E; Miften M; Goodman KA; Schefter T; Olsen J; Vinogradskiy Y
  • Cardiac motion and its dosimetric impact during radioablation for refractory ventricular tachycardia.
    J Appl Clin Med Phys Volume: 24 Page(s): e13925
    06/01/2023 Authors: Harms J; Schreibmann E; Mccall NS; Lloyd MS; Higgins KA; Castillo R
  • Gender-Based Discrimination and Sexual Harassment in Medical Physics.
    Int J Radiat Oncol Biol Phys Volume: 116 Page(s): 314 - 327
    06/01/2023 Authors: Paradis KC; Ryan KA; Covington EL; Schmid S; Simiele SJ; Chapman CH; Castillo R; Moran JM; Matuszak MM; Bott-Kothari T
  • 2021 AAPM Equity, Diversity, and Inclusion Climate Survey Executive Summary.
    Int J Radiat Oncol Biol Phys Volume: 116 Page(s): 295 - 304
    06/01/2023 Authors: Hendrickson KRG; Avery SM; Castillo R; Cervino L; Cetnar A; Gagne NL; Harris W; Johnson A; Lipford ME; Octave N
  • Equity, Diversity, and Inclusion Are Essential in Medical Physics.
    Int J Radiat Oncol Biol Phys Volume: 116 Page(s): 290 - 294
    06/01/2023 Authors: Pollard-Larkin JM; Roth TM; Seuntjens J; Ngwa W; Avery S; Osterman S; Rivera J; Perez-Andujar A; Castillo R
  • Perspectives on Health Disparities and Inequities in Radiation Oncology and Opportunities for Medical Physicists: From Awareness to Action.
    Int J Radiat Oncol Biol Phys Volume: 116 Page(s): 6 - 11
    05/01/2023 Authors: Al-Hallaq H; Castillo R; van der Horst A; Deville C; Carlson DJ
  • Is individual perfusion dose-response different than ventilation dose-response for lung cancer patients treated with radiotherapy?
    Br J Radiol Volume: 96 Page(s): 20220119
    03/01/2023 Authors: Forghani F; Castillo R; Castillo E; PhD BJ; Rusthoven C; Kwak J; Moiseenko V; Grills I; Miften M; Vinogradskiy Y
  • Characterizing Pulmonary Function Test Changes for Patients With Lung Cancer Treated on a 2-Institution, 4-Dimensional Computed Tomography-Ventilation Functional Avoidance Prospective Clinical Trial.
    Adv Radiat Oncol Volume: 8 Page(s): 101133
    01/01/2023 Authors: Miller R; Castillo R; Castillo E; Jones BL; Miften M; Kavanagh B; Lu B; Werner-Wasik M; Ghassemi N; Lombardo J
  • Diversity and Professional Advancement in Medical Physics.
    Adv Radiat Oncol Volume: 8 Page(s): 101057
    01/01/2023 Authors: Rankin J; Whelan B; Pollard-Larkin J; Paradis KC; Scarpelli M; Sun C; Mehta C; Farahani K; Castillo R
  • Pneumonitis Prediction Modeling of a Prospective 4DCT-Ventilation Functional Avoidance Clinical Trial
    Volume: 114 Page(s): S60 - S61
    11/01/2022 Authors: Nourzadeh H; Castillo R; Castillo E; Jones BL; Miften M; Kavanagh BD; Lu B; Werner-Wasik M; Grills IS; Guerrero TM
  • COVID-19 Effects on Medical Education: A Viral Transfer of Knowledge to Radiation Oncology.
    Int J Radiat Oncol Biol Phys Volume: 113 Page(s): 705 - 713
    07/15/2022 Authors: Campbell SR; Castillo R; Lalani N; Ingledew P-A
  • Advancing EDI at Every Level of Med Phys Part 1: For Trainees, the Workplace and Beyond
    Volume: 49 Page(s): E301 - E301
    06/01/2022 Authors: Castillo R; Castillo R; Paradis K; Ainsworth V
  • Physics-Informed Machine Learning for Estimating Pulmonary Perfusion From Non-Contract 4DCT
    Volume: 49 Page(s): E125 - E125
    06/01/2022 Authors: Liu Y; Nowacki A; Castillo R; Vinogradskiy Y; Nair G; Stevens C; Castillo E
  • Changes in post-treatment cardiac PET avidity predict overall survival in lung cancer patients treated with chemoradiation: Secondary analysis of the ACRIN 6668/RTOG 0235 clinical trial.
    Radiother Oncol Volume: 171 Page(s): 22 - 24
    06/01/2022 Authors: Miller R; Santangelo T; Forghani-Arani F; Rusthoven C; Chen Y; Castillo E; Castillo R; Guerrero T; Vinogradskiy Y
  • Results of a Multi-Institutional Phase 2 Clinical Trial for 4DCT-Ventilation Functional Avoidance Thoracic Radiation Therapy.
    Int J Radiat Oncol Biol Phys Volume: 112 Page(s): 986 - 995
    03/15/2022 Authors: Vinogradskiy Y; Castillo R; Castillo E; Schubert L; Jones BL; Faught A; Gaspar LE; Kwak J; Bowles DW; Waxweiler T
  • Diversity in Medical Physics Research Leadership: Quantifying the Representation of Racial, Cultural, and Sex Identity Minority Groups
    Volume: 44 Page(s): S126 - S127
    10/01/2021 Authors: Castillo R; Rankin J; Whelan B; Pollard-Larkin J; Scarpelli M; Farahani K
  • Functional avoidance-based intensity modulated proton therapy with 4DCT derived ventilation imaging for lung cancer.
    J Appl Clin Med Phys Volume: 22 Page(s): 276 - 285
    07/01/2021 Authors: Dougherty JM; Castillo E; Castillo R; Faught AM; Pepin M; Park SS; Beltran CJ; Guerrero T; Grills I; Vinogradskiy Y
  • Characterizing spatial differences between SPECT-ventilation and SPECT-perfusion in patients with lung cancer undergoing radiotherapy.
    Radiother Oncol Volume: 160 Page(s): 120 - 124
    07/01/2021 Authors: Forghani F; Patton T; Kwak J; Thomas D; Diot Q; Rusthoven C; Castillo R; Castillo E; Grills I; Guerrero T
  • Knowledge-Based Cardiac Sparing Treatment Planning for Lung Radiotherapy
    Volume: 48
    06/01/2021 Authors: Harms J; Zhang J; Kayode O; Wolf J; Tian S; McCall N; Higgins K; Castillo R; Yang X
  • Quantifying pulmonary perfusion from noncontrast computed tomography.
    Med Phys Volume: 48 Page(s): 1804 - 1814
    04/01/2021 Authors: Castillo E; Nair G; Turner-Lawrence D; Myziuk N; Emerson S; Al-Katib S; Westergaard S; Castillo R; Vinogradskiy Y; Quinn T
  • Implementation of a Knowledge-Based Treatment Planning Model for Cardiac-Sparing Lung Radiation Therapy.
    Adv Radiat Oncol Volume: 6 Page(s): 100745
    01/01/2021 Authors: Harms J; Zhang J; Kayode O; Wolf J; Tian S; McCall N; Higgins KA; Castillo R; Yang X
  • Technical Note: On the spatial correlation between robust CT-ventilation methods and SPECT ventilation.
    Med Phys Volume: 47 Page(s): 5731 - 5738
    11/01/2020 Authors: Castillo E; Castillo R; Vinogradskiy Y; Nair G; Grills I; Guerrero T; Stevens C
  • Severity of radiation pneumonitis, from clinical, dosimetric and biological features: a pilot study.
    Radiat Oncol Volume: 15 Page(s): 246
    10/27/2020 Authors: Aso S; Navarro-Martin A; Castillo R; Padrones S; Castillo E; Montes A; Martnez JI; Cubero N; Lpez R; Rodrguez L
  • A learning-based automatic segmentation and quantification method on left ventricle in gated myocardial perfusion SPECT imaging: A feasibility study.
    J Nucl Cardiol Volume: 27 Page(s): 976 - 987
    06/01/2020 Authors: Wang T; Lei Y; Tang H; He Z; Castillo R; Wang C; Li D; Higgins K; Liu T; Curran WJ
  • Validation of Robust CT-Ventilation Methods
    Volume: 47 Page(s): E562 - E562
    06/01/2020 Authors: Castillo E; Castillo R; Vinogradskiy Y; Nair G; Grills I; Guerrero T; Stevens C
  • Lung Functional Avoidance Radiotherapy: Characterizing Spatial Differences Between Ventilation and Perfusion
    Volume: 47 Page(s): E370 - E370
    06/01/2020 Authors: Forghani F; Patton T; Thomas D; Diot Q; Rusthoven C; Castillo R; Castillo E; Grills I; Guerrero T; Miften M
  • CT-Derived Pulmonary Perfusion
    Volume: 47 Page(s): E523 - E523
    06/01/2020 Authors: Castillo E; Castillo R; Vinogradskiy Y; Nair G; Grills I; Guerrero T; Stevens C
  • Evaluating Positron Emission Tomography-Based Functional Imaging Changes in the Heart After Chemo-Radiation for Patients With Lung Cancer.
    Int J Radiat Oncol Biol Phys Volume: 106 Page(s): 1063 - 1070
    04/01/2020 Authors: Vinogradskiy Y; Diot Q; Jones B; Castillo R; Castillo E; Kwak J; Bowles D; Grills I; Myziuk N; Guerrero T
  • Robust HU-based CT ventilation from an integrated mass conservation formulation.
    Med Phys Volume: 46 Page(s): 5036 - 5046
    11/01/2019 Authors: Castillo E; Vinogradskiy Y; Castillo R
  • Evaluating PET-Based Functional Imaging Changes in the Heart after Thoracic Chemo-Radiation
    Volume: 105 Page(s): S235 - S235
    09/01/2019 Authors: Vinogradskiy Y; Diot Q; Jones BL; Castillo R; Castillo E; Kwak J; Bowles DW; Grills IS; Guerrero TM; Stevens CW
  • An Integrated Mass Conservation Formulation for Robust Intensity-Based Computed Tomography (CT) Ventilation
    Volume: 46 Page(s): E300 - E300
    06/01/2019 Authors: Castillo E; Vinogradskiy Y; Castillo R
  • Robust CT ventilation from the integral formulation of the Jacobian.
    Med Phys Volume: 46 Page(s): 2115 - 2125
    05/01/2019 Authors: Castillo E; Castillo R; Vinogradskiy Y; Dougherty M; Solis D; Myziuk N; Thompson A; Guerra R; Nair G; Guerrero T
  • Technical Note: Deriving ventilation imaging from 4DCT by deep convolutional neural network.
    Med Phys Volume: 46 Page(s): 2323 - 2329
    05/01/2019 Authors: Zhong Y; Vinogradskiy Y; Chen L; Myziuk N; Castillo R; Castillo E; Guerrero T; Jiang S; Wang J
  • Characterizing Spatial Lung Function for Esophageal Cancer Patients Undergoing Radiation Therapy.
    Int J Radiat Oncol Biol Phys Volume: 103 Page(s): 738 - 746
    03/01/2019 Authors: Pinder-Arabpour A; Jones B; Castillo R; Castillo E; Guerrero T; Goodman K; Schefter T; Kwak J; Miften M; Vinogradskiy Y
  • Predictors of pneumonitis-free survival following lung stereotactic body radiation therapy.
    Transl Lung Cancer Res Volume: 8 Page(s): 15 - 23
    02/01/2019 Authors: Tian S; Switchenko JM; Cassidy RJ; Escott CE; Castillo R; Patel PR; Curran WJ; Higgins KA
  • Functional-guided radiotherapy using knowledge-based planning.
    Radiother Oncol Volume: 129 Page(s): 494 - 498
    12/01/2018 Authors: Faught AM; Olsen L; Schubert L; Rusthoven C; Castillo E; Castillo R; Zhang J; Guerrero T; Miften M; Vinogradskiy Y
  • The Expanding Role of Physiologic Imaging in Radiation Oncology.
    Int J Radiat Oncol Biol Phys Volume: 102 Page(s): 694 - 697
    11/15/2018 Authors: Carlson DJ; Castillo R; Kashani R; Klein EE
  • Interim Analysis of a Two-Institution, Prospective Clinical Trial of 4DCT-Ventilation-based Functional Avoidance Radiation Therapy.
    Int J Radiat Oncol Biol Phys Volume: 102 Page(s): 1357 - 1365
    11/15/2018 Authors: Vinogradskiy Y; Rusthoven CG; Schubert L; Jones B; Faught A; Castillo R; Castillo E; Gaspar LE; Kwak J; Waxweiler T
  • Using 4DCT-ventilation to characterize lung function changes for pediatric patients getting thoracic radiotherapy.
    J Appl Clin Med Phys Volume: 19 Page(s): 407 - 412
    09/01/2018 Authors: Vinogradskiy Y; Faught A; Castillo R; Castillo E; Guerrero T; Miften M; Liu AK
  • Cone Beans CT-Ventilation From Mass Conserving Point Cloud Density Functions
    Volume: 45 Page(s): E129 - E129
    06/01/2018 Authors: Castillo F; Castillo R; Vinogradskiy V; Solis D; Thompson A; Guerrero T
  • Characterizing Spatial Lung Function for Esophageal Cancer Patients
    Volume: 45 Page(s): E581 - E581
    06/01/2018 Authors: Pinder-Arabpour A; Jones B; Castillo R; Castillo E; Guerrero T; Goodman K; Schefter T; Kwak I; Miften M; Vinogradskiy Y
  • Deriving Ventilation Imaging From 4DCT by Deep Convolutional Neural Network
    Volume: 45 Page(s): E155 - E155
    06/01/2018 Authors: Zhong Y; Vinogradskiy Y; Chen L; Myziuk N; Castillo R; Castillo E; Guerrero T; Jiang S; Wang J
  • Evaluating the Toxicity Reduction With Computed Tomographic Ventilation Functional Avoidance Radiation Therapy.
    Int J Radiat Oncol Biol Phys Volume: 99 Page(s): 325 - 333
    10/01/2017 Authors: Faught AM; Miyasaka Y; Kadoya N; Castillo R; Castillo E; Vinogradskiy Y; Yamamoto T
  • Radiation Dose Response Modeling Using CT-Derived Ventilation Imaging
    Volume: 99 Page(s): E644 - E644
    10/01/2017 Authors: Castillo E; Myziuk NK; Zhang J; Vinogradskiy Y; Castillo R; Guerrero TM
  • Evaluating Which Dose-Function Metrics Are Most Critical for Functional-Guided Radiation Therapy.
    Int J Radiat Oncol Biol Phys Volume: 99 Page(s): 202 - 209
    09/01/2017 Authors: Faught AM; Yamamoto T; Castillo R; Castillo E; Zhang J; Miften M; Vinogradskiy Y
  • Automated identification and reduction of artifacts in cine four-dimensional computed tomography (4DCT) images using respiratory motion model.
    Int J Comput Assist Radiol Surg Volume: 12 Page(s): 1521 - 1532
    09/01/2017 Authors: Li M; Castillo SJ; Castillo R; Castillo E; Guerrero T; Xiao L; Zheng X
  • Incorporation of pre-therapy 18 F-FDG uptake data with CT texture features into a radiomics model for radiation pneumonitis diagnosis.
    Med Phys Volume: 44 Page(s): 3686 - 3694
    07/01/2017 Authors: Anthony GJ; Cunliffe A; Castillo R; Pham N; Guerrero T; Armato SG; Al-Hallaq HA
  • Accuracy Preserving Normalization of Deformable Image Registration Solutions for Robust CT-Derived Ventilation Imaging
    Volume: 44 Page(s): 3168 - 3168
    06/01/2017 Authors: Castillo E; Zhang J; Vinogradskiy Y; Castillo R; Guerrero T
  • Functional-Guided Radiotherapy Using Knowledge-Based Planning
    Volume: 44
    06/01/2017 Authors: Faught A; Schubert L; Olsen L; Zhang J; Castillo E; Castillo R; Guerrero T; Vinogradskiy Y
  • Using 4DCT-Ventilation to Evaluate Lung Response for Pediatric Patients Getting Thoracic Radiotherapy
    Volume: 44 Page(s): 3075 - 3075
    06/01/2017 Authors: Vinogradskiy Y; Faught A; Castillo E; Castillo R; Liu A; Miften M
  • A complete 4DCT-ventilation functional avoidance virtual trial: Developing strategies for prospective clinical trials.
    J Appl Clin Med Phys Volume: 18 Page(s): 144 - 152
    05/01/2017 Authors: Waxweiler T; Schubert L; Diot Q; Faught A; Stuhr K; Castillo R; Castillo E; Guerrero T; Rusthoven C; Gaspar L
  • The numerical stability of transformation-based CT ventilation.
    Int J Comput Assist Radiol Surg Volume: 12 Page(s): 569 - 580
    04/01/2017 Authors: Castillo E; Castillo R; Vinogradskiy Y; Guerrero T
  • Assessing the use of 4DCT-ventilation in pre-operative surgical lung cancer evaluation.
    Med Phys Volume: 44 Page(s): 200 - 208
    01/01/2017 Authors: Vinogradskiy Y; Jackson M; Schubert L; Jones B; Castillo R; Castillo E; Guerrero T; Mitchell J; Rusthoven C; Miften M
  • Gemcitabine-induced radiation recall myositis in a patient with relapsed nasopharyngeal carcinoma.
    Pract Radiat Oncol Volume: 7 Page(s): e19 - e22
    01/01/2017 Authors: Patel SC; Paulino AC; Johnston D; Wiederhold L; Castillo R; Venkatramani R
  • A Novel Lung Function Imaging Modality for Surgical Lung Cancer Evaluation
    Volume: 96 Page(s): S46 - S46
    10/01/2016 Authors: Jackson MW; Schubert LK; Jones B; Castillo R; Castillo E; Guerrero TM; Miften M; Mitchell JD; Kavanagh BD; Vinogradskiy Y
  • Regional Lung Function Profiles of Stage I and III Lung Cancer Patients: An Evaluation for Functional Avoidance Radiation Therapy.
    Int J Radiat Oncol Biol Phys Volume: 95 Page(s): 1273 - 1280
    07/15/2016 Authors: Vinogradskiy Y; Schubert L; Diot Q; Waxweiller T; Koo P; Castillo R; Castillo E; Guerrero T; Rusthoven C; Gaspar L
  • Evaluating the Toxicity Reduction with CT-Ventilation Functional Avoidance Radiation Therapy
    Volume: 43 Page(s): 3794 - 3794
    06/01/2016 Authors: Vinogradskiy Y; Miyasaka Y; Kadoya N; Castillo R; Castillo E; Guerrero T; Yamamoto T
  • 4DCT-Ventilation: A Novel Imaging Modality for Thoracic Surgical Evaluation
    MEDICAL PHYSICS Volume: 43 Page(s): 3792 - 3792
    06/01/2016 Authors: Vinogradskiy Y; Jackson M; Schubert L; Jones B; Castillo R; Castillo E; Guerrero T; Mitchell J; Kavanagh B; Miften M
  • Assessing 4DCT-ventilation as a functional imaging modality for thoracic radiation therapy
    Volume: 119 Page(s): S192 - S193
    04/01/2016 Authors: Vinogradskiy Y; Schubert L; Waxweiler T; Diot Q; Castillo R; Castillo E; Guerrero T; Rusthoven C; Gaspar LE; Kavanagh B
  • GPU-accelerated Block Matching Algorithm for Deformable Registration of Lung CT Images.
    Volume: 2015 Page(s): 292 - 295
    12/01/2015 Authors: Li M; Xiang Z; Xiao L; Castillo E; Castillo R; Guerrero T
  • Clinical validation of 4-dimensional computed tomography ventilation with pulmonary function test data.
    Int J Radiat Oncol Biol Phys Volume: 92 Page(s): 423 - 429
    06/01/2015 Authors: Brennan D; Schubert L; Diot Q; Castillo R; Castillo E; Guerrero T; Martel MK; Linderman D; Gaspar LE; Miften M
  • Pre-Radiation Therapy Fluorine 18 Fluorodeoxyglucose PET Helps Identify Patients with Esophageal Cancer at High Risk for Radiation Pneumonitis.
    Radiology Volume: 275 Page(s): 822 - 831
    06/01/2015 Authors: Castillo R; Pham N; Castillo E; Aso-Gonzalez S; Ansari S; Hobbs B; Palacio D; Skinner H; Guerrero TM
  • Incorporation of Pre-Therapy 18F-FDG Uptake with CT Texture Features in a Predictive Model for Radiation Pneumonitis Development
    Volume: 42 Page(s): 3324 - 3324
    06/01/2015 Authors: Anthony G; Cunliffe A; Castillo R; Pham N; Guerrero T; Armato S; Al-Hallaq H
  • Morphometry-based measurements of the structural response to whole-brain radiation.
    Int J Comput Assist Radiol Surg Volume: 10 Page(s): 393 - 401
    04/01/2015 Authors: Fuentes D; Contreras J; Yu J; He R; Castillo E; Castillo R; Guerrero T
  • Lung texture in serial thoracic computed tomography scans: correlation of radiomics-based features with radiation therapy dose and radiation pneumonitis development.
    Int J Radiat Oncol Biol Phys Volume: 91 Page(s): 1048 - 1056
    04/01/2015 Authors: Cunliffe A; Armato SG; Castillo R; Pham N; Guerrero T; Al-Hallaq HA
  • Evaluation of 4D CT acquisition methods designed to reduce artifacts.
    J Appl Clin Med Phys Volume: 16 Page(s): 4949
    03/08/2015 Authors: Castillo SJ; Castillo R; Castillo E; Pan T; Ibbott G; Balter P; Hobbs B; Guerrero T
  • Quality assurance assessment of diagnostic and radiation therapy-simulation CT image registration for head and neck radiation therapy: anatomic region of interest-based comparison of rigid and deformable algorithms.
    Radiology Volume: 274 Page(s): 752 - 763
    03/01/2015 Authors: Mohamed ASR; Ruangskul M-N; Awan MJ; Baron CA; Kalpathy-Cramer J; Castillo R; Castillo E; Guerrero TM; Kocak-Uzel E; Yang J
  • Higher Doses to Smaller Volumes Explains Higher Proton Therapy Radiation Pneumonitis Rates Found
    Volume: 90 Page(s): S80 - S80
    11/15/2014 Authors: Pham N; Castillo R; Castillo R; Hobbs B; Guerrero T
  • Higher Doses to Smaller Volumes Explains Higher Proton Therapy Radiation Pneumonitis Rates Found
    Volume: 90 Page(s): S61 - S61
    09/01/2014 Authors: Pham N; Castillo R; Castillo R; Hobbs B; Guerrero T
  • Deformable image registration for temporal subtraction of chest radiographs.
    Int J Comput Assist Radiol Surg Volume: 9 Page(s): 513 - 522
    07/01/2014 Authors: Li M; Castillo E; Luo H-Y; Zheng X-L; Castillo R; Meshkov D; Guerrero T
  • Improved Cine Four-Dimensional Computed Tomography (4D CT) Acquisition and Processing Method
    Volume: 41
    06/01/2014 Authors: Castillo S; Castillo R; Castillo E; Pan T; Ibbott G; Balter P; Hobbs B; Dai J; Guerrero T
  • A Moving Least Squares Approach for Computing Spatially Accurate Transformations That Satisfy Strict Physiologic Constraints
    Volume: 41
    06/01/2014 Authors: Castillo E; Castillo R; Fuentes D; Guerrero T
  • BEST IN PHYSICS (IMAGING) - Correlating 4DCT-Ventilation with Clinical Pulmonary Function Test Data
    Volume: 41 Page(s): 465 - +
    06/01/2014 Authors: Vinogradskiy Y; Castillo R; Castillo E; Guerrero T; Miften M; Kavanagh B; Martel M; Schubert L
  • Evaluation of image registration spatial accuracy using a Bayesian hierarchical model.
    Biometrics Volume: 70 Page(s): 366 - 377
    06/01/2014 Authors: Liu S; Yuan Y; Castillo R; Guerrero T; Johnson VE
  • Morphometry Based Measurements of the Structural Response to Whole Brain Radiation
    MEDICAL PHYSICS Volume: 41
    06/01/2014 Authors: Fuentes D; Castillo R; Castillo E; Guerrero T
  • Assessment of a quantitative metric for 4D CT artifact evaluation by observer consensus.
    J Appl Clin Med Phys Volume: 15 Page(s): 4718
    05/08/2014 Authors: Castillo SJ; Castillo R; Balter P; Pan T; Ibbott G; Hobbs B; Yuan Y; Guerrero T
  • Comparison of 4-dimensional computed tomography ventilation with nuclear medicine ventilation-perfusion imaging: a clinical validation study.
    Int J Radiat Oncol Biol Phys Volume: 89 Page(s): 199 - 205
    05/01/2014 Authors: Vinogradskiy Y; Koo PJ; Castillo R; Castillo E; Guerrero T; Gaspar LE; Miften M; Kavanagh BD
  • Computing global minimizers to a constrained B-spline image registration problem from optimal l1 perturbations to block match data.
    Med Phys Volume: 41 Page(s): 041904
    04/01/2014 Authors: Castillo E; Castillo R; Fuentes D; Guerrero T
  • Pre-radiotherapy FDG PET predicts radiation pneumonitis in lung cancer.
    Radiat Oncol Volume: 9 Page(s): 74
    03/13/2014 Authors: Castillo R; Pham N; Ansari S; Meshkov D; Castillo S; Li M; Olanrewaju A; Hobbs B; Castillo E; Guerrero T
  • ATM Gene Variations Predict Differences in Pretreatment Lung Inflammation in Nog-Small Cell Lung Cancer (NSCLC) Patients
    Volume: 87 Page(s): S112 - S113
    10/01/2013 Authors: Meshkov D; Guerrero T; Ting X; Pham N; Li M; Awan M; Castillo S; Castillo R; Tucker S; Liao Z
  • Using 4DCT-Based Ventilation Imaging to Evaluate Major Ventilation Defects for Lung Cancer Patients: A Clinical Validation Study
    Volume: 87 Page(s): S201 - S201
    10/01/2013 Authors: Vinogradskiy Y; Castillo R; Castillo E; Guerrero T; Martel MK; Kavanagh B; Miften M
  • Pre-Radiation Therapy FDG PET Predicts Radiation Pneumonitis in Non-Small Cell Lung Cancer (NSCLC) Patients
    Volume: 87 Page(s): S539 - S539
    10/01/2013 Authors: Meshkov D; Sheu T; Hobbs B; Castillo R; Pham N; Guerrero T; Gomez D; Liao Z
  • Deformable Registration of Lung Computed Tomography Images Using Biomechanical Model
    Volume: 87 Page(s): S541 - S542
    10/01/2013 Authors: Li M; Castillo E; Luo H; Zheng X; Castillo R; Meshkov D; Tan L; Wu Y; Zhang S; Guerrero T
  • Modeling lung deformation: a combined deformable image registration method with spatially varying Young's modulus estimates.
    Med Phys Volume: 40 Page(s): 081902
    08/01/2013 Authors: Li M; Castillo E; Zheng X-L; Luo H-Y; Castillo R; Wu Y; Guerrero T
  • Use of 4-dimensional computed tomography-based ventilation imaging to correlate lung dose and function with clinical outcomes.
    Int J Radiat Oncol Biol Phys Volume: 86 Page(s): 366 - 371
    06/01/2013 Authors: Vinogradskiy Y; Castillo R; Castillo E; Tucker SL; Liao Z; Guerrero T; Martel MK
  • The Role of Lung Lobes in Radiation Pneumonitis and Radiation-Induced Inflammation in the Lung: A Retrospective Study.
    J Radiat Oncol Volume: 2 Page(s): 203 - 208
    06/01/2013 Authors: McCurdy M; Bergsma DP; Hyun E; Kim T; Choi E; Castillo R; Castillo E; Guerrero T
  • A reference dataset for deformable image registration spatial accuracy evaluation using the COPDgene study archive.
    Phys Med Biol Volume: 58 Page(s): 2861 - 2877
    05/07/2013 Authors: Castillo R; Castillo E; Fuentes D; Ahmad M; Wood AM; Ludwig MS; Guerrero T
  • Proton therapy radiation pneumonitis local dose-response in esophagus cancer patients.
    Radiother Oncol Volume: 106 Page(s): 124 - 129
    01/01/2013 Authors: Echeverria AE; McCurdy M; Castillo R; Bernard V; Ramos NV; Buckley W; Castillo E; Liu P; Martinez J; Guerrero T
  • Hyperpolarized (3)He magnetic resonance imaging: comparison with four-dimensional x-ray computed tomography imaging in lung cancer.
    Acad Radiol Volume: 19 Page(s): 1546 - 1553
    12/01/2012 Authors: Mathew L; Wheatley A; Castillo R; Castillo E; Rodrigues G; Guerrero T; Parraga G
  • Predicting Symptomatic Radiation Pneumonitis Using Exhaled Nitric Oxide and [18F]Fluorodeoxyglucose Positron Emission Tomography
    Volume: 84 Page(s): S41 - S41
    11/01/2012 Authors: McCurdy MR; Wazni M; Hyun E; Wei C; Castillo E; Castillo R; Block A; Pham N; Guerrero TM
  • Least median of squares filtering of locally optimal point matches for compressible flow image registration.
    Phys Med Biol Volume: 57 Page(s): 4827 - 4833
    08/07/2012 Authors: Castillo E; Castillo R; White B; Rojo J; Guerrero T
  • Poster - Thur Eve - 16: Four-dimensional x-ray computed tomography and hyperpolarized 3 He magnetic resonance imaging of gas distribution in lung cancer.
    Med Phys Volume: 39 Page(s): 4627
    07/01/2012 Authors: Mathew L; Castillo R; Castillo E; Yaremko B; Rodrigues G; Etemad-Rezai R; Guerrero T; Parraga G
  • [18F]-FDG uptake dose-response correlates with radiation pneumonitis in lung cancer patients.
    Radiother Oncol Volume: 104 Page(s): 52 - 57
    07/01/2012 Authors: McCurdy MR; Castillo R; Martinez J; Al Hallack MN; Lichter J; Zouain N; Guerrero T
  • Spatial correspondence of 4D CT ventilation and SPECT pulmonary perfusion defects in patients with malignant airway stenosis.
    Phys Med Biol Volume: 57 Page(s): 1855 - 1871
    04/07/2012 Authors: Castillo R; Castillo E; McCurdy M; Gomez DR; Block AM; Bergsma D; Joy S; Guerrero T
  • Use of weekly 4DCT-based ventilation maps to quantify changes in lung function for patients undergoing radiation therapy.
    Med Phys Volume: 39 Page(s): 289 - 298
    01/01/2012 Authors: Vinogradskiy YY; Castillo R; Castillo E; Chandler A; Martel MK; Guerrero T
  • Ventilation from four-dimensional computed tomography: density versus Jacobian methods.
    Phys Med Biol Volume: 55 Page(s): 4661 - 4685
    08/21/2010 Authors: Castillo R; Castillo E; Martinez J; Guerrero T
  • Four-dimensional deformable image registration using trajectory modeling.
    Phys Med Biol Volume: 55 Page(s): 305 - 327
    01/07/2010 Authors: Castillo E; Castillo R; Martinez J; Shenoy M; Guerrero T
  • Implementation and evaluation of various demons deformable image registration algorithms on a GPU.
    Phys Med Biol Volume: 55 Page(s): 207 - 219
    01/07/2010 Authors: Gu X; Pan H; Liang Y; Castillo R; Yang D; Choi D; Castillo E; Majumdar A; Guerrero T; Jiang SB
  • A framework for evaluation of deformable image registration spatial accuracy using large landmark point sets.
    Phys Med Biol Volume: 54 Page(s): 1849 - 1870
    04/07/2009 Authors: Castillo R; Castillo E; Guerra R; Johnson VE; McPhail T; Garg AK; Guerrero T
  • Interior landmarks improve deformable image registration spatial accuracy in the lung
    Volume: 72 Page(s): S452 - S452
    01/01/2008 Authors: Castillo R; McPhail T; Guerra R; Warren J; Garg A; Guerrero T
  • Reduction of pulmonary compliance found with high-resolution computed tomography in irradiated mice.
    Int J Radiat Oncol Biol Phys Volume: 67 Page(s): 879 - 887
    03/01/2007 Authors: Guerrero T; Castillo R; Noyola-Martinez J; Torres M; Zhou X; Guerra R; Cody D; Komaki R; Travis E
  • Novel method to calculate pulmonary compliance images in rodents from computed tomography acquired at constant pressures.
    Phys Med Biol Volume: 51 Page(s): 1101 - 1112
    03/07/2006 Authors: Guerrero T; Castillo R; Sanders K; Price R; Komaki R; Cody D
  • Attenuation correction of PET images with respiration-averaged CT images in PET/CT.
    J Nucl Med Volume: 46 Page(s): 1481 - 1487
    09/01/2005 Authors: Pan T; Mawlawi O; Nehmeh SA; Erdi YE; Luo D; Liu HH; Castillo R; Mohan R; Liao Z; Macapinlac HA
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