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Profile

Ramireddy Bommireddy

  • Department of Pathology and Laboratory Medicine
    Assistant Professor
  • ramireddy.bommireddy@emory.edu
Head shot of Ramireddy Bommireddy

Education

Degrees

  • PhD from Indian Institute of Science Bangalore

Research

Publications

  • Chemoprevention of Head and Neck Cancer: A Review of Current Approaches and Future Perspectives.
    Cancer Prev Res (Phila) Volume: 17 Page(s): 443 - 455
    10/01/2024 Authors: Han S; Bommireddy R; Kim P; Selvaraj P; Shin DM
  • Tumor-Intrinsic Enhancer of Zeste Homolog 2 Controls Immune Cell Infiltration, Tumor Growth, and Lung Metastasis in a Triple-Negative Breast Cancer Model.
    Int J Mol Sci Volume: 25
    05/15/2024 Authors: Monterroza L; Parrilla MM; Samaranayake SG; Rivera-Rodriguez DE; Yoon SB; Bommireddy R; Hosten J; Barragan LC; Marcus A; Dobosh BS
  • Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice.
    Immun Ageing Volume: 20 Page(s): 20
    05/11/2023 Authors: Park BR; Bommireddy R; Chung DH; Kim K-H; Subbiah J; Jung Y-J; Bhatnagar N; Pack CD; Ramachandiran S; Reddy SJC
  • The magic of small-molecule drugs during ex vivo expansion in adoptive cell therapy.
    Front Immunol Volume: 14 Page(s): 1154566
    01/01/2023 Authors: Zhang H; Passang T; Ravindranathan S; Bommireddy R; Jajja MR; Yang L; Selvaraj P; Paulos CM; Waller EK
  • Influenza Virus-like Particle-Based Hybrid Vaccine Containing RBD Induces Immunity against Influenza and SARS-CoV-2 Viruses.
    Vaccines (Basel) Volume: 10
    06/14/2022 Authors: Bommireddy R; Stone S; Bhatnagar N; Kumari P; Munoz LE; Oh J; Kim K-H; Berry JTL; Jacobsen KM; Jaafar L
  • Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy.
    J Immunother Cancer Volume: 9
    11/01/2021 Authors: Munoz LE; Huang L; Bommireddy R; Sharma R; Monterroza L; Guin RN; Samaranayake SG; Pack CD; Ramachandiran S; Reddy SJC
  • Dendritic Cells Pulsed with Cytokine-Adjuvanted Tumor Membrane Vesicles Inhibit Tumor Growth in HER2-Positive and Triple Negative Breast Cancer Models.
    Int J Mol Sci Volume: 22
    08/04/2021 Authors: Munoz LE; Monterroza L; Bommireddy R; Shafizadeh Y; Pack CD; Ramachandiran S; Reddy SJC; Selvaraj P
  • Humanized mice challenged with TNBC tumor develop graft versus host disease and anemia limiting vaccine immunotherapy studies
    Volume: 206
    05/01/2021 Authors: Bommireddy R; Munoz LE; Pack C; Ramachandiran S; Reddy S; Selvaraj P
  • Expression of tdTomato and luciferase in a murine lung cancer alters the growth and immune microenvironment of the tumor.
    PLoS One Volume: 16 Page(s): e0254125
    01/01/2021 Authors: Huang L; Bommireddy R; Munoz LE; Guin RN; Wei C; Ruggieri A; Menon AP; Li X; Shanmugam M; Owonikoko TK
  • Tumor membrane-based vaccine immunotherapy in combination with anti-CTLA-4 antibody confers protection against immune checkpoint resistant murine triple-negative breast cancer.
    Hum Vaccin Immunother Volume: 16 Page(s): 3184 - 3193
    12/01/2020 Authors: Pack CD; Bommireddy R; Munoz LE; Patel JM; Bozeman EN; Dey P; Radhakrishnan V; Vartabedian VF; Venkat K; Ramachandiran S
  • Metformin reduces PD-L1 expression in the tumor and enhances the efficacy of vaccine generated CD8 T cells in a murine model of triple negative breast cancer
    Volume: 204
    05/01/2020 Authors: Munoz LE; Huang HL; Guin RN; Bommireddy R; Selvaraj P
  • Tumor membrane vesicle-based vaccine immunotherapy inhibits tumor growth and metastasis of squamous cell carcinoma of head and neck in mice
    Volume: 204
    05/01/2020 Authors: Bommireddy R; Munoz LE; Pack C; Ramachandiran S; Reddy S; Chen G; Saba N; Shin DM; Selvaraj P
  • Tumor Membrane Vesicle Vaccine Augments the Efficacy of Anti-PD1 Antibody in Immune Checkpoint Inhibitor-Resistant Squamous Cell Carcinoma Models of Head and Neck Cancer.
    Vaccines (Basel) Volume: 8
    04/14/2020 Authors: Bommireddy R; Munoz LE; Kumari A; Huang L; Fan Y; Monterroza L; Pack CD; Ramachandiran S; Reddy SJC; Kim J
  • Metformin reduces PD-L1 expression in the tumor and enhances the efficacy of vaccine-generated CD8 T cells in a murine model of triple-negative breast cancer.
    Volume: 8 Page(s): 101 - 102
    03/01/2020 Authors: Munoz LE; Bommireddy R; Huang HL; Pack CD; Ramachandiran S; Selvaraj P
  • Tumor membrane vesicle-based vaccine inhibits growth of squamous cell carcinoma of head and neck in mice
    Volume: 49 Page(s): 1693 - 1693
    10/01/2019 Authors: Bommireddy R; Munoz L; Pack C; Ramachandiran S; Reddy S; Kim J; Chen G; Saba N; Shin D; Selvaraj P
  • TMV vaccine inhibits growth of squamous cell carcinoma of head and neck in mice
    Volume: 79
    07/01/2019 Authors: Bommireddy R; Munoz L; Pack CD; Ramachandiran S; Reddy SJC; Kim J; Chen G; Saba NF; Shin DM; Selvaraj P
  • Immunotherapy with TMV vaccine inhibits metastatic tumor growth in an immune checkpoint resistant murine lung cancer model
    Volume: 79
    07/01/2019 Authors: Huang HL; Bommireddy R; Munoz LE; Menon AP; Ramalingam S; Selvaraj P
  • Metformin enhances the efficacy of tumor membrane vesicle (TMV)-based vaccine immunotherapy in a murine model of breast
    Volume: 79
    07/01/2019 Authors: Munoz LE; Bommireddy R; Huang H; Kim J; Selvaraj P
  • Personalized T cell therapy for metastatic colon cancer.
    Volume: 37
    05/20/2019 Authors: Ravindranathan S; Jajja MR; Waller A; Bommireddy R; Petersen C; Selvaraj P; Yang L; Lesinski GB; El-Rayes BF; Flynn B
  • Immunotherapy with tumor membrane vesicle based cancer vaccine inhibits metastatic tumor growth in lung cancer model
    Volume: 202
    05/01/2019 Authors: Bommireddy R; Huang HL; Munoz LE; Menon AP; Ramalingam S; Selvaraj P
  • Tumor membrane vesicle (TMV)-based cancer vaccine induces dendritic cell maturation and downstream T cell activation
    Volume: 200
    05/01/2018 Authors: Munoz LE; Shafizadeh Y; Margaroli C; Bommireddy R; Selvaraj P
  • Efficacy of immunotherapy approaches in metastatic and non-metastatic lung cancer models
    Volume: 200
    05/01/2018 Authors: Bommireddy R; Menon AP; Munoz LE; Huang L; Kim J; Kumar J; Lakshmanan R; Ramalingam SS; Selvaraj P
  • Membrane-based immunotherapy with immune checkpoint blockade antibodies confers protection against metastatic breast cancer
    Volume: 198
    05/01/2017 Authors: Bommireddy R; Pack CD; Bozeman EN; Patel JM; Vartebedian VF; Munoz LE; Shafizadeh Y; Menon AP; Lakshmanan R; Reddy SJC
  • HER-2(+) breast cancer cells expressing GPI-anchored cytokines induce long lasting anti-tumor memory response
    Volume: 46 Page(s): 227 - 227
    08/01/2016 Authors: Bommireddy R; Margaroli C; Shafizadeh Y; Bozeman E; Munoz L; Menon A; Selvaraj P
  • Imaging colon cancer development in mice: IL-6 deficiency prevents adenoma in azoxymethane-treated Smad3 knockouts.
    Phys Med Biol Volume: 61 Page(s): N60 - N69
    02/07/2016 Authors: Harpel K; Leung S; Rice PF; Jones M; Barton JK; Bommireddy R
  • Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography.
    Cancer Growth Metastasis Volume: 8 Page(s): 63 - 80
    01/01/2015 Authors: LeGendre-McGhee S; Rice PS; Wall RA; Sprute KJ; Bommireddy R; Luttman AM; Nagle RB; Abril ER; Farrell K; Hsu C-H
  • Characterization of a novel mouse model for human B-cell lymphomas
    Volume: 188
    05/01/2012 Authors: Bommireddy R; Besselsen D; Rimsza L
  • SMAD3 deficiency causes immune dysregulation, colitis and colon tumorigenesis
    Volume: 186
    04/01/2011 Authors: Bommireddy R; Ball C; Cherukuri D; Nasr M; Doetschman T
  • Divergent effects of calcineurin A on regulatory and conventional T-cell homeostasis.
    Clin Immunol Volume: 138 Page(s): 321 - 330
    03/01/2011 Authors: Doetschman T; Sholl A; Chen HDR; Gard C; Hildeman DA; Bommireddy R
  • Lack of TGF-Beta Signaling in Dendritic Cells Leads to Systemic Autoimmunity
    Volume: 138 Page(s): S129 - S129
    05/01/2010 Authors: Ramalingam R; Larmonier CB; Bommireddy R; Midura-Kiela MT; Ghishan FK; Kiela PR
  • Lack of TGF-beta signaling in dendritic cells leads to systemic autoimmunity
    Volume: 24
    04/01/2010 Authors: Ramalingam R; Larmonier CB; Bommireddy R; Ghishan FK; Kiela PR
  • Calcineurin A beta signalling is required for Treg-cell generation and prevention of T-cell activation and B-cell lymphomagenesis
    Volume: 184
    04/01/2010 Authors: Bommireddy R; Chen D; Gard C; Molkentin J; Rimsza L; Doetschman T
  • Calcineurin deficiency decreases inflammatory lesions in transforming growth factor beta1-deficient mice.
    Clin Exp Immunol Volume: 158 Page(s): 317 - 324
    12/01/2009 Authors: Bommireddy R; Bueno OF; Martin J; Ormsby I; Chen H; Gard C; Molkentin JD; Boivin GP; Babcock GF; Doetschman T
  • Generation of mice with a conditional allele for transforming growth factor beta 1 gene.
    Genesis Volume: 47 Page(s): 423 - 431
    06/01/2009 Authors: Azhar M; Yin M; Bommireddy R; Duffy JJ; Yang J; Pawlowski SA; Boivin GP; Engle SJ; Sanford LP; Grisham C
  • Calcineurin Ab deficiency causes defective Treg-cell generation and enhanced effector T-cell differentiation
    Volume: 182
    04/01/2009 Authors: Bommireddy R; Chen H; Gard C; Molkentin JD; Doetschman T
  • TGFbeta1 deficiency does not affect the generation and maintenance of CD4+CD25+FOXP3+ putative Treg cells, but causes their numerical inadequacy and loss of regulatory function.
    Clin Immunol Volume: 127 Page(s): 206 - 213
    05/01/2008 Authors: Bommireddy R; Babcock GF; Singh RR; Doetschman T
  • Calcineurin Deficiency Decreases Inflammatory Lesions in TGFbeta1-deficient Mice
    Volume: 22
    04/01/2008 Authors: Bommireddy R; Bueno OF; Martin J; Ormsby I; Chen D; Molkentin JD; Boivin GP; Babcock GF; Doetschman T
  • Dual roles of immunoregulatory cytokine TGF-beta in the pathogenesis of autoimmunity-mediated organ damage.
    J Immunol Volume: 180 Page(s): 1903 - 1912
    02/01/2008 Authors: Saxena V; Lienesch DW; Zhou M; Bommireddy R; Azhar M; Doetschman T; Singh RR
  • TGFbeta1 and Treg cells: alliance for tolerance.
    Trends Mol Med Volume: 13 Page(s): 492 - 501
    11/01/2007 Authors: Bommireddy R; Doetschman T
  • TGFbeta1 is not essential for generation and maintenance of natural Treg cells
    Volume: 178
    04/01/2007 Authors: Bommireddy R; Babcock GF; Singh RR; Doetschman T
  • Self-antigen recognition by TGF beta1-deficient T cells causes their activation and systemic inflammation.
    Lab Invest Volume: 86 Page(s): 1008 - 1019
    10/01/2006 Authors: Bommireddy R; Pathak LJ; Martin J; Ormsby I; Engle SJ; Boivin GP; Babcock GF; Eriksson AU; Singh RR; Doetschman T
  • Self-antigen recognition causes T-cell activation and systemic inflammation in TGFb1-deficient mice
    Volume: 176 Page(s): S282 - S282
    04/01/2006 Authors: Bommireddy R; Pathak LJ; Martin J; Boivin GP; Babcock GF; Doetschman T
  • TGF beta1 prevents activation of self-antigen reactive T cells and protects from autoimmune disease
    Volume: 19 Page(s): A328 - A328
    03/04/2005 Authors: Bommireddy R; Pathak LJ; Martin J; Ormsby I; Boivin GP; Babcock GF; Doetschman T
  • Tgfb1 KO T cells do not require antigenic stimulation for activation due to altered threshold levels of activation
    Volume: 18 Page(s): A1169 - A1169
    03/24/2004 Authors: Doetschman T; Boivin GP; Babcock GF; Ormsby I; Bommireddy R
  • TGF-beta, T-cell tolerance and anti-CD3 therapy.
    Trends Mol Med Volume: 10 Page(s): 3 - 9
    01/01/2004 Authors: Bommireddy R; Doetschman T
  • Elimination of both CD4+ and CD8+ T cells but not B cells eliminates inflammation and prolongs the survival of TGFbeta1-deficient mice.
    Cell Immunol Volume: 232 Page(s): 96 - 104
    01/01/2004 Authors: Bommireddy R; Engle SJ; Ormsby I; Boivin GP; Babcock GF; Doetschman T
  • TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes.
    J Immunol Volume: 170 Page(s): 4612 - 4622
    05/01/2003 Authors: Bommireddy R; Saxena V; Ormsby I; Yin M; Boivin GP; Babcock GF; Singh RR; Doetschman T
  • TGFbetal modulates Ca2(+)-dependent threshold levels of activation in T cells
    Volume: 17 Page(s): C175 - C175
    04/14/2003 Authors: Bommireddy R; Engle SJ; Saxena V; Ormsby I; Babcock GF; Singh RR; Doetschman T
  • TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes.
    J Immunol Volume: 170 Page(s): 3645 - 3652
    04/01/2003 Authors: Bommireddy R; Ormsby I; Yin M; Boivin GP; Babcock GF; Doetschman T
  • TGF beta 1 prevents autoimmune response by maintaining [Ca2+]i homeostasis in T cells
    Page(s): 73 - 78
    01/01/2003 Authors: Doetschman T; Babcock GF; Ormsby I; Yin M; Bommireddy R
  • Transforming growth factor beta1 inhibits Ca2+-calcineurin-mediated activation in thymocytes.
    Volume: 16 Page(s): A1060 - A1060
    03/22/2002 Authors: Bommireddy R; Saxena V; Ormsby I; Yin MY; Singh RR; Babcock GF; Doetschman T
  • Role of Transforming Growth Factor 1 in Lymphocyte Development and Death.
    ScientificWorldJournal Volume: 1 Page(s): 146
    01/01/2001 Authors: Bommireddy R; Ormsby I; Yin M; Doetschman TC
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