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Profile

Paula Vertino PhD

  • Department of Radiation Oncology
    Professor Emeritus
  • (404) 778-3119
  • pvertin@emory.edu
Head shot of Paula Vertino

Overview

Dr. Vertino is a cancer research scientist internationally recognized for her work in the field of cancer epigenetics. She has a longstanding record of extramural research support from the NCI, the American Cancer Society, NASA and the Georgia Cancer Coalition.

She served as leader of the Cancer Genetics and Epigenetics Program of the Winship Cancer Institute while at Emory. She previously served as the Director of Graduate Studies for the Cancer Biology Graduate Program and was the co-director for research for the Hematology and Medical Oncology Fellowship Program. She also served as a regular member on the Cancer Etiology study section at the NIH, and is a former member of the editorial board of Cancer Research.

While at Emory, Dr. Vertino was actively engaged in graduate and postgraduate education as well as trained and mentored numerous graduate students, postdoctoral fellows and medical residents in her laboratory.

Dr. Vertino received her BS in biochemistry from the State University of New York at Stony Brook, where she was a Phi Beta Kappa inductee. She pursued graduate work at the Roswell Park Cancer Institute, receiving her PhD from the State University of New York at Buffalo in 1990. After postdoctoral training in cancer genetics at the Johns Hopkins Oncology Center, Dr. Vertino joined the faculty of Emory University in 1996.

Dr. Vertino received several local honors and awards, including induction into the 'Millipub Club' and the 'Emory 1%', recognizing Emory faculty that have authored articles cited more than 1000 times, and with NIH grants scoring in the top 1% at peer review. She was invited to the board of Faculty of 1000.

Dr. Vertino's research interests are focused on the areas of cancer epigenetics and novel mechanisms of gene silencing in cancer. Her work has been funded by the National Cancer Institute, American Cancer Society and Georgia Cancer Coalition.

Dr. Vertino has published extensively on cancer epigenetics and novel mechanisms of gene silencing in cancer. She received several awards including an Avon Breast Cancer Scholar Award for her work on the TMS1 gene and its role in breast carcinogenesis.

Academic Appointment

  • Professor (with tenure), Department of Radiation Oncology, Emory University School of Medicine

Education

Degrees

  • PhD from Roswell Park Cancer Institute Graduate Division
  • BS from State University of New York at Stony Brook

Research

Focus

  • The major interests of my laboratory center around the epigenetic mechanisms that drive human tumorigenesis. Current studies are aimed at understanding the molecular basis for aberrant gene silencing through the study of DNA methylation, DNA/histone methyltransferases and chromatin structure.

Publications

  • TGF-1-mediated intercellular signaling fuels cooperative cellular invasion.
    Cell Rep Volume: 44 Page(s): 115315
    02/25/2025 Authors: Khatib TO; Pedro BA; Bombin S; Matsuk VY; Robinson IE; Webster SF; Marcus LJ; Summerbell ER; Tharp GK; Knippler CM
  • Systemic inflammation and changes in physical well-being in patients with breast cancer: a longitudinal study in community oncology settings.
    Oncologist Volume: 30
    02/06/2025 Authors: Gilmore N; Li Y; Seplaki CL; Sohn M; Yang Y; Li C-S; Loh KP; Lin P-J; Kleckner A; Mohamed M
  • The effect of YOCAS yoga on cancer-related fatigue and quality of life in older (60+) vs. younger ( 59) cancer survivors: Secondary analysis of a nationwide, multicenter, phase 3 randomized controlled trial.
    J Geriatr Oncol Volume: 15 Page(s): 102076
    11/01/2024 Authors: Arana-Chicas E; Lin P-J; Gada U; Sun H; Chakrabarti A; Mattick LJ; Rieth K; Chay CH; Ruzich J; Esparaz BT
  • Transposon DNA sequences facilitate the tissue-specific gene transfer of circulating tumor DNA between human cells.
    Nucleic Acids Res Volume: 52 Page(s): 7539 - 7555
    07/22/2024 Authors: Cinar M; Martinez-Medina L; Puvvula PK; Arakelyan A; Vardarajan BN; Anthony N; Nagaraju GP; Park D; Feng L; Sheff F
  • Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies.
    Exp Gerontol Volume: 187 Page(s): 112364
    03/01/2024 Authors: Loh KP; Wang Y; Sanapala C; Gilmore N; Netherby-Winslow C; Mendler JH; Liesveld J; Huselton E; Williams AM; Klepin HD
  • Epigenetic and inflammatory markers in older adults with cancer: A Young International Society of Geriatric Oncology narrative review.
    J Geriatr Oncol Volume: 15 Page(s): 101655
    01/01/2024 Authors: Gilmore N; Loh KP; Liposits G; Arora SP; Vertino P; Janelsins M
  • Exercise and epigenetic ages in older adults with myeloid malignancies.
    Eur J Med Res Volume: 28 Page(s): 180
    05/30/2023 Authors: Loh KP; Sanapala C; Jensen-Battaglia M; Rana A; Sohn MB; Watson E; Gilmore N; Klepin HD; Mendler JH; Liesveld J
  • Arid1a mutation suppresses TGF- signaling and induces cholangiocarcinoma.
    Cell Rep Volume: 40 Page(s): 111253
    08/30/2022 Authors: Guo B; Friedland SC; Alexander W; Myers JA; Wang W; O'Dell MR; Getman M; Whitney-Miller CL; Agostini-Vulaj D; Huber AR
  • A single-arm pilot study of a mobile health exercise intervention (GO-EXCAP) in older patients with myeloid neoplasms.
    Blood Adv Volume: 6 Page(s): 3850 - 3860
    07/12/2022 Authors: Loh KP; Sanapala C; Watson EE; Jensen-Battaglia M; Janelsins MC; Klepin HD; Schnall R; Culakova E; Vertino P; Susiarjo M
  • Protocol for a pilot randomized controlled trial of a mobile health exercise intervention for older patients with myeloid neoplasms (GO-EXCAP 2).
    J Geriatr Oncol Volume: 13 Page(s): 545 - 553
    05/01/2022 Authors: Loh KP; Sanapala C; Janelsins M; Klepin HD; Schnall R; Culakova E; Sohn MB; Vertino P; Susiarjo M; Jensen-Battaglia M
  • Combined Inhibition of G9a and EZH2 Suppresses Tumor Growth via Synergistic Induction of IL24-Mediated Apoptosis.
    Cancer Res Volume: 82 Page(s): 1208 - 1221
    04/01/2022 Authors: Casciello F; Kelly GM; Ramarao-Milne P; Kamal N; Stewart TA; Mukhopadhyay P; Kazakoff SH; Miranda M; Kim D; Davis FM
  • Subtype-Independent ANP32E Reduction During Breast Cancer Progression in Accordance with Chromatin Relaxation.
    BMC Cancer Volume: 21 Page(s): 1342
    12/18/2021 Authors: Ruff GL; Murphy KE; Smith ZR; Vertino PM; Murphy PJ
  • Urolithiasis/Endourology.
    J Urol Volume: 206 Page(s): 1321 - 1324
    11/01/2021 Authors: Assimos DG
  • Developing and adapting a mobile health exercise intervention for older patients with myeloid neoplasms: A qualitative study.
    J Geriatr Oncol Volume: 12 Page(s): 909 - 914
    07/01/2021 Authors: Loh KP; Sanapala C; Di Giovanni G; Klepin HD; Janelsins M; Schnall R; Culakova E; Vertino P; Susiarjo M; Mendler JH
  • Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple Myeloma.
    Clin Cancer Res Volume: 27 Page(s): 3178 - 3189
    06/01/2021 Authors: Barwick BG; Gupta VA; Matulis SM; Patton JC; Powell DR; Gu Y; Jaye DL; Conneely KN; Lin YC; Hofmeister CC
  • Ten-eleven translocation protein 1 modulates medulloblastoma progression.
    Genome Biol Volume: 22 Page(s): 125
    04/29/2021 Authors: Kim H; Kang Y; Li Y; Chen L; Lin L; Johnson ND; Zhu D; Robinson MH; McSwain L; Barwick BG
  • Acetylation of KLF5 maintains EMT and tumorigenicity to cause chemoresistant bone metastasis in prostate cancer.
    Nat Commun Volume: 12 Page(s): 1714
    03/17/2021 Authors: Zhang B; Li Y; Wu Q; Xie L; Barwick B; Fu C; Li X; Wu D; Xia S; Chen J
  • Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score7.
    Dis Markers Volume: 2021 Page(s): 8858905
    01/01/2021 Authors: Miyauchi T; Takahashi M; Mitsuzuka K; Saiki Y; Okubo T; Vertino PM; Goto A; Arai Y; Horii A; Fukushige S
  • Epigenetically heterogeneous tumor cells direct collective invasion through filopodia-driven fibronectin micropatterning.
    Sci Adv Volume: 6 Page(s): eaaz6197
    07/01/2020 Authors: Summerbell ER; Mouw JK; Bell JSK; Knippler CM; Pedro B; Arnst JL; Khatib TO; Commander R; Barwick BG; Konen J
  • Prognostic significance of an invasive leader cell-derived mutation cluster on chromosome 16q.
    Cancer Volume: 126 Page(s): 3140 - 3150
    07/01/2020 Authors: Pedro B; Rupji M; Dwivedi B; Kowalski J; Konen JM; Owonikoko TK; Ramalingam SS; Vertino PM; Marcus AI
  • Genetic heterogeneity within collective invasion packs drives leader and follower cell phenotypes.
    J Cell Sci Volume: 132
    10/09/2019 Authors: Zoeller EL; Pedro B; Konen J; Dwivedi B; Rupji M; Sundararaman N; Wang L; Horton JR; Zhong C; Barwick BG
  • DNA methylation reprogramming in relapsed/refractory myeloma converges with loci prognostic of survival in newly diagnosed patients
    Volume: 19 Page(s): E57 - E57
    10/01/2019 Authors: Barwick B; Skerget S; Keats J; Auclair D; Lonial S; Boise L; Vertino P
  • Whole genome DNA methylation analysis of multiple myeloma identifies pervasive hypomethylation and biomarkers of survival
    Volume: 79
    07/01/2019 Authors: Barwick BG; Powell DR; Penaherrera D; Skerget S; Keats JJ; Auclair D; Lonial S; Boise LH; Vertino PM
  • Dissecting the biology of leader and follower cells in collective cancer invasion
    Volume: 79
    07/01/2019 Authors: Pedro BA; Konen J; Summerbell E; Mouw JK; Rupji M; Dwivedi B; Kowalski J; Vertino PM; Marcus AI
  • Multiple myeloma immunoglobulin lambda translocations portend poor prognosis.
    Nat Commun Volume: 10 Page(s): 1911
    04/23/2019 Authors: Barwick BG; Neri P; Bahlis NJ; Nooka AK; Dhodapkar MV; Jaye DL; Hofmeister CC; Kaufman JL; Gupta VA; Auclair D
  • Cell of Origin and Genetic Alterations in the Pathogenesis of Multiple Myeloma.
    Front Immunol Volume: 10 Page(s): 1121
    01/01/2019 Authors: Barwick BG; Gupta VA; Vertino PM; Boise LH
  • Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
    J Med Chem Volume: 61 Page(s): 10588 - 10601
    12/13/2018 Authors: Horton JR; Woodcock CB; Chen Q; Liu X; Zhang X; Shanks J; Rai G; Mott BT; Jansen DJ; Kales SC
  • Immunoglobulin Lambda Translocations Identify Poor Outcome and IMiD Resistance in Multiple Myeloma and Co-Occur with Hyperdiploidy
    Volume: 132
    11/29/2018 Authors: Barwick BG; Neri P; Bahlis N; Nooka AK; Kaufman JL; Gupta VA; Auclair D; Keats JJ; Lonial S; Vertino PM
  • Identification of the Transcription Factor Relationships Associated with Androgen Deprivation Therapy Response and Metastatic Progression in Prostate Cancer.
    Cancers (Basel) Volume: 10
    10/11/2018 Authors: Sharma NV; Pellegrini KL; Ouellet V; Giuste FO; Ramalingam S; Watanabe K; Adam-Granger E; Fossouo L; You S; Freeman MR
  • Transcription factor relationships associated with androgen-deprivation therapy response and metastatic progression in prostate cancer
    Volume: 78
    07/01/2018 Authors: Sharma NV; Pellegrini KL; Ouellet V; Giuste FO; Ramalingam S; Watanabe K; Adam-Granger E; Fossouo L; You S; Freeman MR
  • Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer.
    Sci Rep Volume: 8 Page(s): 6709
    04/30/2018 Authors: Kennedy EM; Powell DR; Li Z; Bell JSK; Barwick BG; Feng H; McCrary MR; Dwivedi B; Kowalski J; Dynan WS
  • Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A.
    J Med Chem Volume: 61 Page(s): 3193 - 3208
    04/12/2018 Authors: Horton JR; Liu X; Wu L; Zhang K; Shanks J; Zhang X; Rai G; Mott BT; Jansen DJ; Kales SC
  • 14-3-3 binds the proteasome, limits proteolytic function and enhances sensitivity to proteasome inhibitors.
    Leukemia Volume: 32 Page(s): 744 - 751
    03/01/2018 Authors: Gu Y; Xu K; Torre C; Samur M; Barwick BG; Rupji M; Arora J; Neri P; Kaufman J; Nooka A
  • High-Risk Myeloma Is Demarcated By Immunoglobulin Lambda Light Chain Translocations
    Volume: 130
    12/07/2017 Authors: Barwick B; Gupta VA; Auclair D; Keats JJ; Lonial S; Vertino PM; Boise LH
  • Using an image-guided genomics platform to probe the phenotypic heterogenetiy of collective cancer invasion
    Volume: 34 Page(s): 491 - 491
    12/01/2017 Authors: Konen J; Summerbell E; Vertino P; Marcus A
  • Regulation of invasion by lysine demethylase 5B in non-small cell lung cancer cells
    Volume: 77
    07/01/2017 Authors: Zoeller EL; Konen J; Bell J; Summerbell E; Kowalski J; Marcus A; Vertino P
  • Orphan CpG islands define a novel class of highly active enhancers.
    Epigenetics Volume: 12 Page(s): 449 - 464
    06/03/2017 Authors: Bell JSK; Vertino PM
  • Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion.
    Nat Commun Volume: 8 Page(s): 15078
    05/12/2017 Authors: Konen J; Summerbell E; Dwivedi B; Galior K; Hou Y; Rusnak L; Chen A; Saltz J; Zhou W; Boise LH
  • MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma.
    Nucleic Acids Res Volume: 45 Page(s): 2396 - 2407
    03/17/2017 Authors: Wang D; Hashimoto H; Zhang X; Barwick BG; Lonial S; Boise LH; Vertino PM; Cheng X
  • Leader cells are defined by DNA hypermethylation and aberrant gene expression during collective lung cancer invasion.
    Volume: 28
    01/01/2017 Authors: Summerbell ER; Bell J; Konen J; Kowalski J; Vertino PM; Marcus AI
  • Leader cells are defined by DNA hypermethylation and aberrant gene expression during collective lung cancer invasion.
    Volume: 28
    01/01/2017 Authors: Summerbell ER; Bell J; Konen J; Kowalski J; Vertino PM; Marcus AI
  • Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds.
    Cell Chem Biol Volume: 23 Page(s): 769 - 781
    07/21/2016 Authors: Horton JR; Liu X; Gale M; Wu L; Shanks JR; Zhang X; Webber PJ; Bell JSK; Kales SC; Mott BT
  • A hot L1 retrotransposon evades somatic repression and initiates human colorectal cancer.
    Genome Res Volume: 26 Page(s): 745 - 755
    06/01/2016 Authors: Scott EC; Gardner EJ; Masood A; Chuang NT; Vertino PM; Devine SE
  • Gene integrated set profile analysis: a context-based approach for inferring biological endpoints.
    Nucleic Acids Res Volume: 44 Page(s): e69
    04/20/2016 Authors: Kowalski J; Dwivedi B; Newman S; Switchenko JM; Pauly R; Gutman DA; Arora J; Gandhi K; Ainslie K; Doho G
  • Factors affecting the persistence of drug-induced reprogramming of the cancer methylome.
    Epigenetics Volume: 11 Page(s): 273 - 287
    04/02/2016 Authors: Bell JSK; Kagey JD; Barwick BG; Dwivedi B; McCabe MT; Kowalski J; Vertino PM
  • Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.
    J Biol Chem Volume: 291 Page(s): 2631 - 2646
    02/05/2016 Authors: Horton JR; Engstrom A; Zoeller EL; Liu X; Shanks JR; Zhang X; Johns MA; Vertino PM; Fu H; Cheng X
  • Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenstrm macroglobulinemia.
    Oncogene Volume: 35 Page(s): 479 - 490
    01/28/2016 Authors: Gaudette BT; Dwivedi B; Chitta KS; Poulain S; Powell D; Vertino P; Leleu X; Lonial S; Chanan-Khan AA; Kowalski J
  • GC skew defines distinct RNA polymerase pause sites in CpG island promoters
    Volume: 76
    01/15/2016 Authors: Bell JSK; Kellner WA; Vertino PM
  • Identifying genomic signatures of rare cancer cells within a heterogeneous collective invasive pack.
    Volume: 27
    01/01/2016 Authors: Pedro B; Konen J; Summerbell E; Li W; Dwivedi B; Kowalski J; Vertino PM; Marcus AI
  • GC skew defines distinct RNA polymerase pause sites in CpG island promoters.
    Genome Res Volume: 25 Page(s): 1600 - 1609
    11/01/2015 Authors: Kellner WA; Bell JSK; Vertino PM
  • Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer.
    Oncotarget Volume: 6 Page(s): 30773 - 30786
    10/13/2015 Authors: Brodie SA; Li G; Harvey D; Khuri FR; Vertino PM; Brandes JC
  • The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations.
    J Biol Chem Volume: 290 Page(s): 20723 - 20733
    08/21/2015 Authors: Hashimoto H; Zhang X; Vertino PM; Cheng X
  • HNF4 regulates claudin-7 protein expression during intestinal epithelial differentiation.
    Am J Pathol Volume: 185 Page(s): 2206 - 2218
    08/01/2015 Authors: Farkas AE; Hilgarth RS; Capaldo CT; Gerner-Smidt C; Powell DR; Vertino PM; Koval M; Parkos CA; Nusrat A
  • Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis.
    Oncotarget Volume: 6 Page(s): 11047 - 11060
    05/10/2015 Authors: Stoyanov E; Ludwig G; Mizrahi L; Olam D; Schnitzer-Perlman T; Tasika E; Sass G; Tiegs G; Jiang Y; Nie T
  • A Formal Scientific Writing Course for Biomedical Graduate Students Enhances Student Training and Success.
    Volume: 26
    01/01/2015 Authors: Corbett AH; Pavlath GK; Vertino PM; Conn GL; Goldberg JB; Kahn RA
  • CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences.
    Nucleic Acids Res Volume: 42 Page(s): 7473 - 7485
    06/01/2014 Authors: Lin Y; Cradick TJ; Brown MT; Deshmukh H; Ranjan P; Sarode N; Wile BM; Vertino PM; Stewart FJ; Bao G
  • Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy.
    Brain Behav Immun Volume: 38 Page(s): 227 - 236
    05/01/2014 Authors: Smith AK; Conneely KN; Pace TWW; Mister D; Felger JC; Kilaru V; Akel MJ; Vertino PM; Miller AH; Torres MA
  • A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing.
    J Biol Chem Volume: 289 Page(s): 7425 - 7437
    03/14/2014 Authors: Kapoor-Vazirani P; Vertino PM
  • Class I HDACs are mediators of smoke carcinogen-induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer.
    Cancer Prev Res (Phila) Volume: 7 Page(s): 351 - 361
    03/01/2014 Authors: Brodie SA; Li G; El-Kommos A; Kang H; Ramalingam SS; Behera M; Gandhi K; Kowalski J; Sica GL; Khuri FR
  • Aberrant promoter methylation of caveolin-1 is associated with favorable response to taxane-platinum combination chemotherapy in advanced NSCLC.
    PLoS One Volume: 9 Page(s): e107124
    01/01/2014 Authors: Brodie SA; Lombardo C; Li G; Kowalski J; Gandhi K; You S; Khuri FR; Marcus A; Vertino PM; Brandes JC
  • Integrated analysis of whole-genome paired-end and mate-pair sequencing data for identifying genomic structural variations in multiple myeloma.
    Cancer Inform Volume: 13 Page(s): 49 - 53
    01/01/2014 Authors: Yang R; Chen L; Newman S; Gandhi K; Doho G; Moreno CS; Vertino PM; Bernal-Mizarchi L; Lonial S; Boise LH
  • Dysregulation of mTOR activity through LKB1 inactivation.
    Chin J Cancer Volume: 32 Page(s): 427 - 433
    08/01/2013 Authors: Zhou W; Marcus AI; Vertino PM
  • Class I HDACs are mediators of smoke-carcinogen induced stabilization of DNMT1 and serve as promising targets for chemoprevention of lung cancer
    CANCER RESEARCH Volume: 73
    07/01/2013 Authors: Brodie SA; Li G; El-Kommos A; Ramalingam SS; Behera M; Kowalski J; Gandhi K; Khuri FH; Vertino P; Brandes JC
  • Dual role of the histone methyltransferase PR-SET7/SETD8 in the local regulation of Pol II promoter-proximal pausing
    CANCER RESEARCH Volume: 73
    07/01/2013 Authors: Kapoor P; Vertino PM
  • Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition.
    PLoS One Volume: 8 Page(s): e75069
    01/01/2013 Authors: Yang Z; Garcia A; Xu S; Powell DR; Vertino PM; Singh S; Marcus AI
  • A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.
    Genome Res Volume: 22 Page(s): 2339 - 2355
    12/01/2012 Authors: Duncan CG; Barwick BG; Jin G; Rago C; Kapoor-Vazirani P; Powell DR; Chi J-T; Bigner DD; Vertino PM; Yan H
  • Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation.
    Nucleic Acids Res Volume: 40 Page(s): 4841 - 4849
    06/01/2012 Authors: Hashimoto H; Liu Y; Upadhyay AK; Chang Y; Howerton SB; Vertino PM; Zhang X; Cheng X
  • TMS1 / ASC is critical for primary ciliogenesis and participates in cell migration
    CANCER RESEARCH Volume: 72
    04/15/2012 Authors: Abreu E; Patel P; Kline E; Marcus A; Vertino P
  • R loops: lassoing DNA methylation at CpGi.
    Mol Cell Volume: 45 Page(s): 708 - 709
    03/30/2012 Authors: Vertino PM; Wade PA
  • Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation.
    Int J Cancer Volume: 129 Page(s): 2744 - 2755
    12/01/2011 Authors: Thaiparambil JT; Bender L; Ganesh T; Kline E; Patel P; Liu Y; Tighiouart M; Vertino PM; Harvey RD; Garcia A
  • OVEREXPRESSION OF MBD2 IN GLIOBLASTOMA SUPPRESSES THE ANTIANGIOGENIC FUNCTION OF THE TUMOR SUPPRESSOR GENE BAI1 BY EPIGENETIC SILENCING
    NEURO-ONCOLOGY Volume: 13 Page(s): 5 - 5
    11/01/2011 Authors: Zhu D; Hunter SB; Vertino PM; Van Meir EG
  • Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1.
    Cancer Res Volume: 71 Page(s): 5859 - 5870
    09/01/2011 Authors: Zhu D; Hunter SB; Vertino PM; Van Meir EG
  • Withaferin A inhibits breast cancer invasion and metastasis at subcytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation
    CANCER RESEARCH Volume: 71
    04/15/2011 Authors: Thaiparambil JT; Bender L; Ganesh T; Kline E; Patel P; Liu Y; Tighiouart M; Vertino PM; Harvey RD; Garcia A
  • SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.
    Mol Cell Biol Volume: 31 Page(s): 1594 - 1609
    04/01/2011 Authors: Kapoor-Vazirani P; Kagey JD; Vertino PM
  • Molecular coupling of DNA methylation and histone methylation.
    Epigenomics Volume: 2 Page(s): 657 - 669
    10/01/2010 Authors: Hashimoto H; Vertino PM; Cheng X
  • Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
    Mol Cancer Res Volume: 8 Page(s): 1048 - 1059
    07/01/2010 Authors: Kagey JD; Kapoor-Vazirani P; McCabe MT; Powell DR; Vertino PM
  • Natural mutagenesis of human genomes by endogenous retrotransposons.
    Cell Volume: 141 Page(s): 1253 - 1261
    06/25/2010 Authors: Iskow RC; McCabe MT; Mills RE; Torene S; Pittard WS; Neuwald AF; Van Meir EG; Vertino PM; Devine SE
  • Age/race differences in HER2 testing and in incidence rates for breast cancer triple subtypes: a population-based study and first report.
    Cancer Volume: 116 Page(s): 2549 - 2559
    06/01/2010 Authors: Lund MJ; Butler EN; Hair BY; Ward KC; Andrews JH; Oprea-Ilies G; Bayakly AR; O'Regan RM; Vertino PM; Eley JW
  • Homozygous deletion of the STK11/LKB1 locus and the generation of novel fusion transcripts in cervical cancer cells.
    Cancer Genet Cytogenet Volume: 197 Page(s): 130 - 141
    03/01/2010 Authors: McCabe MT; Powell DR; Zhou W; Vertino PM
  • Cancer DNA methylation: molecular mechanisms and clinical implications.
    Clin Cancer Res Volume: 15 Page(s): 3927 - 3937
    06/15/2009 Authors: McCabe MT; Brandes JC; Vertino PM
  • Methylation-sensitive regulation of TMS1/ASC by the Ets factor, GA-binding protein-alpha.
    J Biol Chem Volume: 284 Page(s): 14698 - 14709
    05/29/2009 Authors: Lucas ME; Crider KS; Powell DR; Kapoor-Vazirani P; Vertino PM
  • Maintenance of a poised epigenetic state at the TMS1 locus following transient exposure to 5-aza-2\#8217;-deoxycytidine (Decitabine)
    Volume: 69
    05/01/2009 Authors: Kagey J; Kapoor-Vazirani P; Vertino P
  • Targeting of methyl-CpG-binding protein MBD2 reactivates brain angiogenesis inhibitor 1 tumor suppressor activity for the treatment of brain cancer
    CANCER RESEARCH Volume: 69
    05/01/2009 Authors: Zhu D; Reichert Z; Nelson W; Vertino P; Van Meir E
  • Anoikis-induced upregulation of Bim is dependent on TMS1
    Volume: 69
    05/01/2009 Authors: Patel P; Parsons M; Vertino P
  • Repressive epigenetic signatures may predispose CpG islands to hypermethylation in non-small cell lung cancer
    Volume: 69
    05/01/2009 Authors: McCabe M; Vertino P
  • Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells.
    Cancer Res Volume: 69 Page(s): 1706 - 1711
    03/01/2009 Authors: Parsons MJ; Patel P; Brat DJ; Colbert L; Vertino PM
  • A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation.
    Cancer Res Volume: 69 Page(s): 282 - 291
    01/01/2009 Authors: McCabe MT; Lee EK; Vertino PM
  • LKB1 is necessary for Akt-mediated phosphorylation of proapoptotic proteins.
    Cancer Res Volume: 68 Page(s): 7270 - 7277
    09/15/2008 Authors: Zhong D; Liu X; Khuri FR; Sun S-Y; Vertino PM; Zhou W
  • Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells.
    Mol Cancer Res Volume: 6 Page(s): 1421 - 1430
    09/01/2008 Authors: Guo L; Zhong D; Lau S; Liu X; Dong X-Y; Sun X; Yang VW; Vertino PM; Moreno CS; Varma V
  • Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.
    Cancer Res Volume: 68 Page(s): 6810 - 6821
    08/15/2008 Authors: Kapoor-Vazirani P; Kagey JD; Powell DR; Vertino PM
  • Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.
    Mol Cell Volume: 30 Page(s): 336 - 347
    05/09/2008 Authors: Subramanian K; Jia D; Kapoor-Vazirani P; Powell DR; Collins RE; Sharma D; Peng J; Cheng X; Vertino PM
  • The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
    Cancer Res Volume: 68 Page(s): 740 - 748
    02/01/2008 Authors: Zhang S; Schafer-Hales K; Khuri FR; Zhou W; Vertino PM; Marcus AI
  • Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analyses.
    Pituitary Volume: 11 Page(s): 231 - 245
    01/01/2008 Authors: Evans C-O; Moreno CS; Zhan X; McCabe MT; Vertino PM; Desiderio DM; Oyesiku NM
  • leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
    J Biol Chem Volume: 282 Page(s): 13316 - 13325
    05/04/2007 Authors: Saxena NK; Vertino PM; Anania FA; Sharma D
  • Infrequent mutation of ATBF1 in human breast cancer.
    J Cancer Res Clin Oncol Volume: 133 Page(s): 103 - 105
    02/01/2007 Authors: Sun X; Zhou Y; Otto KB; Wang M; Chen C; Zhou W; Subramanian K; Vertino PM; Dong J-T
  • Dual role of TMS1/ASC in death receptor signaling.
    Oncogene Volume: 25 Page(s): 6948 - 6958
    11/02/2006 Authors: Parsons MJ; Vertino PM
  • LKB1 mutation in large cell carcinoma of the lung.
    Lung Cancer Volume: 53 Page(s): 285 - 294
    09/01/2006 Authors: Zhong D; Guo L; de Aguirre I; Liu X; Lamb N; Sun S-Y; Gal AA; Vertino PM; Zhou W
  • TMS1 immunohistochemical expression in ductal carcinoma in situ of the breast: Correlation with tumor characteristics and outcome
    Volume: 19 Page(s): 18 - 18
    09/01/2006 Authors: Nassar A; Tighioura M; Vertino P
  • Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes.
    Cancer Res Volume: 66 Page(s): 6370 - 6378
    06/15/2006 Authors: Sharma D; Saxena NK; Davidson NE; Vertino PM
  • Leptin promotes the proliferative response and invasiveness in human endometrial cancer cells by activating multiple signal-transduction pathways.
    Endocr Relat Cancer Volume: 13 Page(s): 629 - 640
    06/01/2006 Authors: Sharma D; Saxena NK; Vertino PM; Anania FA
  • DNA motifs associated with aberrant CpG island methylation.
    Genomics Volume: 87 Page(s): 572 - 579
    05/01/2006 Authors: Feltus FA; Lee EK; Costello JF; Plass C; Vertino PM
  • Role of TMS1 in detachment-induced apoptosis
    Volume: 66
    04/01/2006 Authors: Parsons MJ; Vertino PM
  • Regulation of ER alpha by the SET7 methyltransferase
    Volume: 66
    04/01/2006 Authors: Subramanian K; Collins RE; Cheng X; Vertino PM
  • Homozygous deletion of LKB1 mutation in H157 lung cancer cell line
    Volume: 66
    04/01/2006 Authors: Zhong D; Guo L; de Aguirre I; Liu X; Lamb N; Sun S; Gal A; Vertino PM; Zhou W
  • LKB1/AMPK/TSC2 signaling pathway alterations in non-small cell lung cancer
    Volume: 49 Page(s): S69 - S69
    07/01/2005 Authors: De Aguirre I; Zhong D; Zhou W; Rosell R; Vertino P
  • Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma.
    Am J Pathol Volume: 165 Page(s): 1151 - 1161
    10/01/2004 Authors: Stone AR; Bobo W; Brat DJ; Devi NS; Van Meir EG; Vertino PM
  • Epigenetic regulation of MDR1 gene in breast cancer: CpG methylation status dominates the stable maintenance of a silent gene.
    Cancer Biol Ther Volume: 3 Page(s): 549 - 550
    06/01/2004 Authors: Sharma D; Vertino PM
  • TMS1/ASC: the cancer connection.
    Apoptosis Volume: 9 Page(s): 5 - 18
    01/01/2004 Authors: McConnell BB; Vertino PM
  • Predicting aberrant CpG island methylation.
    Proc Natl Acad Sci U S A Volume: 100 Page(s): 12253 - 12258
    10/14/2003 Authors: Feltus FA; Lee EK; Costello JF; Plass C; Vertino PM
  • Effects of methylation on expression of TMS1/ASC in human breast cancer cells.
    Oncogene Volume: 22 Page(s): 3475 - 3488
    05/29/2003 Authors: Levine JJ; Stimson-Crider KM; Vertino PM
  • Methylation matters: a new spin on maspin.
    Nat Genet Volume: 31 Page(s): 123 - 124
    06/01/2002 Authors: Costello JF; Vertino PM
  • Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture.
    J Biol Chem Volume: 277 Page(s): 4951 - 4958
    02/15/2002 Authors: Stimson KM; Vertino PM
  • DNMT1 is a component of a multiprotein DNA replication complex.
    Cell Cycle Volume: 1 Page(s): 416 - 423
    01/01/2002 Authors: Vertino PM; Sekowski JA; Coll JM; Applegren N; Han S; Hickey RJ; Malkas LH
  • Identification and characterization of the human MOG1 gene.
    Gene Volume: 266 Page(s): 45 - 56
    03/21/2001 Authors: Marfatia KA; Harreman MT; Fanara P; Vertino PM; Corbett AH
  • Identification and characterization of a human homologue of the S-cerevisiae MOG1 gene
    MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 151A - 151A
    12/01/2000 Authors: Marfatia KA; Harreman MT; Vertino PM; Corbett AH
  • TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers.
    Cancer Res Volume: 60 Page(s): 6236 - 6242
    11/15/2000 Authors: Conway KE; McConnell BB; Bowring CE; Donald CD; Warren ST; Vertino PM
  • Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1.
    Cancer Res Volume: 60 Page(s): 6243 - 6247
    11/15/2000 Authors: McConnell BB; Vertino PM
  • The S-cerevisiae SAC3 gene encodes an evolutionarily conserved protein that is required for nuclear protein export in yeast.
    MOLECULAR BIOLOGY OF THE CELL Volume: 10 Page(s): 442A - 442A
    11/01/1999 Authors: Harreman MT; Jones AL; Singson A; L'Hernault S; Vertino P; Corbett AH
  • Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production.
    Mol Cell Biol Volume: 18 Page(s): 5166 - 5177
    09/01/1998 Authors: Mikovits JA; Young HA; Vertino P; Issa JP; Pitha PM; Turcoski-Corrales S; Taub DD; Petrow CL; Baylin SB; Ruscetti FW
  • Alterations in DNA methylation: a fundamental aspect of neoplasia.
    Adv Cancer Res Volume: 72 Page(s): 141 - 196
    01/01/1998 Authors: Baylin SB; Herman JG; Graff JR; Vertino PM; Issa JP
  • Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells.
    J Biol Chem Volume: 272 Page(s): 32260 - 32266
    12/19/1997 Authors: Ferguson AT; Vertino PM; Spitzner JR; Baylin SB; Muller MT; Davidson NE
  • Mapping patterns of CpG island methylation in normal and neoplastic cells implicates both upstream and downstream regions in de novo methylation.
    J Biol Chem Volume: 272 Page(s): 22322 - 22329
    08/29/1997 Authors: Graff JR; Herman JG; Myhnen S; Baylin SB; Vertino PM
  • New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.
    J Biol Chem Volume: 271 Page(s): 31092 - 31097
    12/06/1996 Authors: Yoder JA; Yen RW; Vertino PM; Bestor TH; Baylin SB
  • Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.
    Proc Natl Acad Sci U S A Volume: 93 Page(s): 11757 - 11762
    10/15/1996 Authors: Issa JP; Vertino PM; Boehm CD; Newsham IF; Baylin SB
  • De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase.
    Mol Cell Biol Volume: 16 Page(s): 4555 - 4565
    08/01/1996 Authors: Vertino PM; Yen RW; Gao J; Baylin SB
  • Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts.
    Cell Growth Differ Volume: 5 Page(s): 1395 - 1402
    12/01/1994 Authors: Vertino PM; Issa JP; Pereira-Smith OM; Baylin SB
  • Increased cytosine DNA-methyltransferase activity during colon cancer progression.
    J Natl Cancer Inst Volume: 85 Page(s): 1235 - 1240
    08/04/1993 Authors: Issa JP; Vertino PM; Wu J; Sazawal S; Celano P; Nelkin BD; Hamilton SR; Baylin SB
  • Isolation of polyadenylated RNA from cultured cells and intact tissues.
    Biotechniques Volume: 15 Page(s): 26 - 28
    07/01/1993 Authors: Celano P; Vertino PM; Casero RA
  • Altered chromosomal methylation patterns accompany oncogene-induced transformation of human bronchial epithelial cells.
    Cancer Res Volume: 53 Page(s): 1684 - 1689
    04/01/1993 Authors: Vertino PM; Spillare EA; Harris CC; Baylin SB
  • New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity.
    Cancer Res Volume: 52 Page(s): 4712 - 4718
    09/01/1992 Authors: Regenass U; Caravatti G; Mett H; Stanek J; Schneider P; Mller M; Matter A; Vertino P; Porter CW
  • Isolation and characterization of the cDNA encoding human DNA methyltransferase.
    Nucleic Acids Res Volume: 20 Page(s): 2287 - 2291
    05/11/1992 Authors: Yen RW; Vertino PM; Nelkin BD; Yu JJ; el-Deiry W; Cumaraswamy A; Lennon GG; Trask BJ; Celano P; Baylin SB
  • Abnormal patterns of DNA methylation in human neoplasia: potential consequences for tumor progression.
    Cancer Cells Volume: 3 Page(s): 383 - 390
    10/01/1991 Authors: Baylin SB; Makos M; Wu JJ; Yen RW; de Bustros A; Vertino P; Nelkin BD
  • Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function.
    Mol Pharmacol Volume: 39 Page(s): 487 - 494
    04/01/1991 Authors: Vertino PM; Beerman TA; Kelly EJ; Bergeron RJ; Porter CW
  • Structural determinants of spermidine-DNA interactions.
    Biopolymers Volume: 26 Page(s): 691 - 703
    05/01/1987 Authors: Vertino PM; Bergeron RJ; Cavanaugh PF; Porter CW
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