Peter Thule MD
Overview
Research
Development of insulin gene therapy as a treatment for diabetes mellitus, and investigations into hepatocellular effects of ectopic insulin production. Our animal model utilizes a metabolically regulated, hepatic specific gene promoter to drive expression of an insulin transgene in the livers of diabetic rats. Administration of viral vectors containing these promoters coupled to a human insulin cDNA, normalizes blood sugars in diabetic rodents.
Academic Appointment
- Professor of Medicine, Department of Medicine, Division of Endocrinology, Metabolism and Lipids, Emory University School of Medicine
- Adjunct Clinical Associate Professor, Department of Internal Medicine, Morehouse School of Medicine
Education
Degrees
- MD from Justus-Liebig University
- BA from University of California
Research
Focus
- Development of insulin gene therapy as a treatment for diabetes mellitus, investigations into hepatocellular effects of ectopic insulin production, and transdifferentiation of autologous somatic cells to produce regulated insulin secretion. Viral vectors using a metabolically regulated, hepatic specific promoter to express human insulin normalizes blood sugars in diabetic animals.
Publications
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Diabetic rats with high levels of endogenous dopamine do not show retinal vascular pathology.
Front Neurosci Volume: 17 Page(s): 1125784
01/01/2023 Authors: Allen RS; Khayat CT; Feola AJ; Win AS; Grubman AR; Chesler KC; He L; Dixon JA; Kern TS; Iuvone PM -
Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy.
Diabetes Volume: 69 Page(s): 1518 - 1527
07/01/2020 Authors: Motz CT; Chesler KC; Allen RS; Bales KL; Mees LM; Feola AJ; Maa AY; Olson DE; Thule PM; Iuvone PM -
Short-term levodopa treatments ameliorate early stage electroretinogram (ERG) delays in diabetic patients
Volume: 60
07/01/2019 Authors: Motz C; Chesler K; Allen RS; Mees L; Olson D; Maa AY; Coulter M; Thule PM; Iuvone PM; Hendrick A -
Retinal Deficits Precede Cognitive and Motor Deficits in a Rat Model of Type II Diabetes.
Invest Ophthalmol Vis Sci Volume: 60 Page(s): 123 - 133
01/02/2019 Authors: Allen RS; Feola A; Motz CT; Ottensmeyer AL; Chesler KC; Dunn R; Thul PM; Pardue MT -
Dopamine Deficiency Mediates Early Rod-Driven Inner Retinal Dysfunction in Diabetic Mice.
Invest Ophthalmol Vis Sci Volume: 59 Page(s): 572 - 581
01/01/2018 Authors: Kim MK; Aung MH; Mees L; Olson DE; Pozdeyev N; Iuvone PM; Thule PM; Pardue MT -
mRNA destabilization improves glycemic responsiveness of transcriptionally regulated hepatic insulin gene therapy in vitro and in vivo.
J Gene Med Volume: 19
03/01/2017 Authors: Thul PM; Lin Y; Jia D; Olson DE; Tang S-C; Sambanis A -
In Vivo Imaging of Retinal Oxidative Stress Using a Reactive Oxygen Species-Activated Fluorescent Probe.
Invest Ophthalmol Vis Sci Volume: 56 Page(s): 5862 - 5870
09/01/2015 Authors: Prunty MC; Aung MH; Hanif AM; Allen RS; Chrenek MA; Boatright JH; Thule PM; Kundu K; Murthy N; Pardue MT -
Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization.
Drug Deliv Transl Res Volume: 5 Page(s): 125 - 136
04/01/2015 Authors: Phelps EA; Templeman KL; Thul PM; Garca AJ -
Long-term glycemic control with hepatic insulin gene therapy in streptozotocin-diabetic mice.
J Gene Med Volume: 17 Page(s): 141 - 152
01/01/2015 Authors: Thul PM; Campbell AG; Jia D; Lin Y; You S; Paveglio S; Olson DE; Kozlowski M -
Hepatic insulin gene therapy prevents diabetic enteropathy in STZ-treated CD-1 mice.
Mol Ther Methods Clin Dev Volume: 2 Page(s): 15028
01/01/2015 Authors: You S; Anitha M; deSouza SM; Jia D; Lu X; Kozlowski M; Olson DE; Srinivasan S; Thul PM