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Profile

Peijian He

  • Department of Medicine
    Assistant Professor
  • (404) 712-2947
  • Emory University
    Department of Medicine
    615 Michael Street, Whitehead Research Bldg, Suite 201C
Head shot of Peijian He

Overview

Dr. Peijian He received his PhD from Kyushu University (Fukuoka, Japan) and completed his postdoctoral training on the molecular regulation of Na+ and fluid absorption in the Division of Digestive Diseases at the Emory University School of Medicine. Dr. He then joined the faculty as an Assistant Professor of Medicine in 2014. Dr. He' current research attempts to understand the molecular machinery that governs systemic iron homeostasis in physiological setting, the mechanisms that cause iron overload in pathological conditions, as well as the cellular stress responses to excessive iron.

Academic Appointment

  • Assistant Professor of Medicine, Emory University

Education

Degrees

  • PhD from Kyushu University
  • MS from Zhejiang University
  • BS from Ludong University

Research

Focus

  • Iron metabolism and associated diseases

    Dr. He' current research attempts to understand the molecular machinery that governs systemic iron homeostasis in physiological setting, the mechanisms that cause iron overload in pathological conditions, as well as the cellular stress responses to excessive iron.

Publications

  • Inhalation exposure to airborne PM2.5 attenuates hepatic metabolic pathways through S-nitrosylation of the primary ER stress sensor.
    Am J Physiol Cell Physiol Volume: 328 Page(s): C212 - C226
    01/01/2025 Authors: Yang Z; Chen Q; Wang J; Qiu Y; Thepsuwan P; Yi Z; Heng HH; Sun Q; Chen X; Li L
  • Targeting PKC alleviates iron overload in diabetes and hemochromatosis through the inhibition of ferroportin.
    Blood Volume: 144 Page(s): 1433 - 1444
    09/26/2024 Authors: Banerjee S; Lu S; Jain A; Wang I; Tao H; Srinivasan S; Nemeth E; He P
  • Differences in hepatocellular iron metabolism underlie sexual dimorphism in hepatocyte ferroptosis.
    Redox Biol Volume: 67 Page(s): 102892
    11/01/2023 Authors: Tao H; Dar HY; Tian C; Banerjee S; Glazer ES; Srinivasan S; Zhu L; Pacifici R; He P
  • HIGH-FAT DIET-INDUCED FERROPTOSIS PROMOTES ENTERIC NEURODEGENERATION: A MECHANISM FOR INTESTINAL MOTILITY DISORDERS
    Volume: 164 Page(s): S93 - S93
    05/01/2023 Authors: Balasubramaniam A; Liu Y; Grants I; Chaudhuri S; Mwangi SM; He P; Christofi FL; Srinivasan S
  • SARS-CoV-2 Induces Epithelial-Enteric Neuronal Crosstalk Stimulating VIP Release.
    Biomolecules Volume: 13
    01/20/2023 Authors: Balasubramaniam A; Tedbury PR; Mwangi SM; Liu Y; Li G; Merlin D; Gracz AD; He P; Sarafianos SG; Srinivasan S
  • Editorial: Microbiome in IBD: From Composition to Therapy, Volume II.
    Front Pharmacol Volume: 14 Page(s): 1184269
    01/01/2023 Authors: Liu N-N; He P; Liu Z; Zhu R; Miao Y; Yu C; Zhu L
  • Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores.
    Redox Biol Volume: 55 Page(s): 102407
    09/01/2022 Authors: Wang Y; Wang M; Liu Y; Tao H; Banerjee S; Srinivasan S; Nemeth E; Czaja MJ; He P
  • ENTERIC NEURONAL VASOACTIVE INTESTINAL PEPTIDE MEDIATES SARS-COV-2 ASSOCIATED DIARRHEA
    Volume: 162 Page(s): S364 - S364
    05/01/2022 Authors: Balasubramaniam A; Tedbury P; Gracz AD; Mwangi SM; Li G; Merlin D; Sarafianos SG; He P; Srinivasan S
  • Nedd4-2-dependent Ubiquitination Potentiates the Inhibition of Human NHE3 by Cholera Toxin and Enteropathogenic Escherichia coli.
    Cell Mol Gastroenterol Hepatol Volume: 13 Page(s): 695 - 716
    01/01/2022 Authors: Jenkin KA; Han Y; Lin S; He P; Yun CC
  • Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPA5-Dependent Signaling.
    Cell Mol Gastroenterol Hepatol Volume: 14 Page(s): 129 - 150
    01/01/2022 Authors: Liang Z; He P; Han Y; Yun CC
  • SARS-CoV-2 induces enteric neuronal production of vasoactive intestinal peptide as a potential mechanism of COVID-19-associated diarrhea
    Volume: 33
    08/01/2021 Authors: He P; Tedbury PR; Gracz A; Mwangi SM; Li G; Merlin D; Sarafianos SG; Srinivasan S
  • SARS-COV-2 INDUCES EPITHYELIAL-NEURONAL CROSSTALK STIMULATING VASOACTIVE INTESTINAL PEPTIDE RELEASE AS A POTENTIAL MECHANISM OF COVID-19-ASSOCIATED DIARRHEA
    Volume: 160 Page(s): S233 - S234
    05/01/2021 Authors: He P; Tedbury P; Gracz AD; Mwangi SM; Li G; Merlin D; Sarafianos SG; Srinivasan S
  • Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
    Cell Mol Gastroenterol Hepatol Volume: 12 Page(s): 1073 - 1092
    01/01/2021 Authors: Wang M; He P; Han Y; Dong L; Yun CC
  • Editorial: Microbiome in IBD: From Composition to Therapy.
    Front Pharmacol Volume: 12 Page(s): 721992
    01/01/2021 Authors: Zhu R; He P; Liu Z; Liu N; Miao Y; Yu C; Zhu L
  • Caspase-11-mediated enteric neuronal pyroptosis underlies Western diet-induced colonic dysmotility.
    J Clin Invest Volume: 130 Page(s): 3621 - 3636
    07/01/2020 Authors: Ye L; Li G; Goebel A; Raju AV; Kong F; Lv Y; Li K; Zhu Y; Raja S; He P
  • LYSOPHSOPHATIDIC ACID RECEPTOR 5 ENHANCES INTESTINAL EPITHELIAL BARRIER BY REGUATING CLAUDIN-4
    Volume: 158 Page(s): S214 - S214
    05/01/2020 Authors: Wang M; He P; Dong L; Yun C
  • THE DEUBIQUITINATING ENZYME USP10 REGULATES NA plus /H plus EXCHANGER NHE3 IN INTESTIAL EPITHELIAL CELLS
    Volume: 158 Page(s): S270 - S270
    05/01/2020 Authors: Han Y; He P; Yun C
  • Hepatic Autonomic Nervous System and Neurotrophic Factors Regulate the Pathogenesis and Progression of Non-alcoholic Fatty Liver Disease.
    Front Med (Lausanne) Volume: 7 Page(s): 62
    01/01/2020 Authors: Amir M; Yu M; He P; Srinivasan S
  • Hyperglycemia promotes microvillus membrane expression of DMT1 in intestinal epithelial cells in a PKC-dependent manner.
    FASEB J Volume: 33 Page(s): 3549 - 3561
    03/01/2019 Authors: Zhao L; Bartnikas T; Chu X; Klein J; Yun C; Srinivasan S; He P
  • Autotaxin determines colitis severity in mice and is secreted by B cells in the colon.
    FASEB J Volume: 33 Page(s): 3623 - 3635
    03/01/2019 Authors: Lin S; Haque A; Raeman R; Guo L; He P; Denning TL; El-Rayes B; Moolenaar WH; Yun CC
  • Memory-Augmented Attention Network for Sequential Recommendation
    WEB INFORMATION SYSTEMS ENGINEERING - WISE 2019 Volume: 11881 Page(s): 228 - 242
    01/01/2019 Authors: Hu C; He P; Sha C; Niu J
  • Inhibition of autotaxin alleviates inflammation and increases the expression of sodium-dependent glucose cotransporter 1 and Na+/H+ exchanger 3 in SAMP1/Fc mice.
    Am J Physiol Gastrointest Liver Physiol Volume: 315 Page(s): G762 - G771
    11/01/2018 Authors: He P; Haque A; Lin S; Cominelli F; Yun CC
  • Expression of lysophosphatidic acid receptor 5 is necessary for the regulation of intestinal Na+/H+ exchanger 3 by lysophosphatidic acid in vivo.
    Am J Physiol Gastrointest Liver Physiol Volume: 315 Page(s): G433 - G442
    10/01/2018 Authors: Jenkin KA; He P; Yun CC
  • Lysophosphatidic Acid Receptor 1 Is Important for Intestinal Epithelial Barrier Function and Susceptibility to Colitis.
    Am J Pathol Volume: 188 Page(s): 353 - 366
    02/01/2018 Authors: Lin S; Han Y; Jenkin K; Lee S-J; Sasaki M; Klapproth J-M; He P; Yun CC
  • Genomics Approach of the Natural Product Pharmacology for High Impact Diseases.
    Int J Genomics Volume: 2018 Page(s): 9468912
    01/01/2018 Authors: Wang Y; Feng Q; He P; Zhu L; Chen G
  • LYSOPHOSPHATIDIC ACID RECEPTOR 5 IS ESSENTIAL FOR INTESTINAL EPITHELIAL RENEWAL
    Volume: 152 Page(s): S350 - S350
    04/01/2017 Authors: He P; Zhao L; Yun C
  • JIANPILIQI FORMULA UPREGULATES NA(+)/HCO3- CO-TRANSPORTER 1 IN THE DUODENUM OF A RAT MODEL OF FUNCTIONAL DYSPEPSIA
    Volume: 152 Page(s): S305 - S306
    04/01/2017 Authors: Zhao L; Zhang S; He P
  • Mechanistic Understanding of Herbal Therapy in Inflammatory Bowel Disease.
    Curr Pharm Des Volume: 23 Page(s): 5173 - 5179
    01/01/2017 Authors: Zhao L; Zhang S; He P
  • The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.
    Am J Physiol Renal Physiol Volume: 311 Page(s): F343 - F351
    08/01/2016 Authors: He P; Zhao L; No YR; Karvar S; Yun CC
  • Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24.
    Am J Physiol Gastrointest Liver Physiol Volume: 310 Page(s): G586 - G598
    04/15/2016 Authors: Yoshida M; Zhao L; Grigoryan G; Shim H; He P; Yun CC
  • Transgenic Expression of Human Lysophosphatidic Acid Receptor LPA2 in Mouse Intestinal Epithelial Cells Induces Intestinal Dysplasia.
    PLoS One Volume: 11 Page(s): e0154527
    01/01/2016 Authors: Yoshida M; He P; Yun CC
  • Rapid Thermal Annealing for Carbon Nanotube Thin Film Transistors by a Double-Themral-Region Furnace

    01/01/2016 Authors: Chen C; Deng Y; He P; Zhang M
  • Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss.
    J Clin Invest Volume: 125 Page(s): 3519 - 3531
    09/01/2015 Authors: He P; Zhao L; Zhu L; Weinman EJ; De Giorgio R; Koval M; Srinivasan S; Yun CC
  • Evidence for a causal link between adaptor protein PDZK1 downregulation and Na/H exchanger NHE3 dysfunction in human and murine colitis.
    Pflugers Arch Volume: 467 Page(s): 1795 - 1807
    08/01/2015 Authors: Yeruva S; Chodisetti G; Luo M; Chen M; Cinar A; Ludolph L; Lnnemann M; Goldstein J; Singh AK; Riederer B
  • Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.
    Am J Physiol Cell Physiol Volume: 309 Page(s): C14 - C21
    07/01/2015 Authors: No YR; He P; Yoo BK; Yun CC
  • Krppel-like factor 5 incorporates into the -catenin/TCF complex in response to LPA in colon cancer cells.
    Cell Signal Volume: 27 Page(s): 961 - 968
    05/01/2015 Authors: Guo L; He P; No YR; Yun CC
  • IRBIT Mediates Trafficking and Activation of Na plus ,K plus -ATPase by Angiotensin II
    Volume: 29
    04/01/2015 Authors: He P; Xie Z; Yun C
  • PDZK1 Expression Is Critical for the Brush Border Membrane Localisation, Membrane Half Life and cAMP-Mediated Regulation of Enterocyte Na+/H+ Exchanger Isoform 3
    Volume: 148 Page(s): S878 - S878
    04/01/2015 Authors: Chodisetti G; Luo M; Yeruva S; He P; Yun C; Seidler U
  • The Absence of NHERF2 Attenuates Colon Cancer Growth
    Volume: 148 Page(s): S47 - S47
    04/01/2015 Authors: Yoshida M; He P; Yun C
  • PDZK1 expression is critical for the brush border membrane localisation, membrane half life and cAMP-mediated regulation of enterocyte Na+/H+ exchanger isoform 3
    ACTA PHYSIOLOGICA Volume: 213 Page(s): 61 - 62
    03/01/2015 Authors: Chodisetti G; Luo M; Yeruva S; He P; Yun C; Seidler U
  • Autotaxin-LPA receptor axis in the pathogenesis of lung diseases.
    Int J Clin Exp Med Volume: 8 Page(s): 17117 - 17122
    01/01/2015 Authors: Chu X; Wei X; Lu S; He P
  • Unique regulation of human Na+/H+ exchanger 3 (NHE3) by Nedd4-2 ligase that differs from non-primate NHE3s.
    J Biol Chem Volume: 289 Page(s): 18360 - 18372
    06/27/2014 Authors: No YR; He P; Yoo BK; Yun CC
  • Insulin and LPA Restore Intestinal Fluid Homeostasis in Type 1 Diabetes via Activation of NHE3
    Volume: 146 Page(s): S784 - S784
    05/01/2014 Authors: He P; Zhu L; Srinivasan S; Yun C
  • Nedd4-2 Uniquely Regulates Human Na plus /H plus Exchanger NHE3 by Ubiquitination
    Volume: 146 Page(s): S50 - S50
    05/01/2014 Authors: No YR; Yoo BK; He P; Yun C
  • Kruppel-Like Factor 5 Plays a Critical Role in beta-Catenin Activation by LPA in Colon Cancer Cells
    Volume: 146 Page(s): S16 - S16
    05/01/2014 Authors: Guo L; He P; No YR; Yun C
  • Activation of intestinal NHE3 by insulin depends on the coordination of IRBIT, NHERF1, and Ezrin
    Volume: 27
    04/01/2013 Authors: He P; Srinivasan S; Yun C
  • Intestinal inflammation induces functional Na+/H+ exchanger 3 defect via downregulation of PDZ-domain adaptor protein PDZK1 (NHERF3)
    Volume: 27
    04/01/2013 Authors: Seidler UE; Yeruva S; Chodisetti G; Luo M; Hagen S; He P; Yun CC
  • Insulin Activates Intestinal NHE3 via IRBIT
    Volume: 26
    04/01/2012 Authors: He P; Yanda M; Anitha M; Srinivasan S; Yun C
  • Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells.
    Am J Physiol Cell Physiol Volume: 301 Page(s): C1008 - C1016
    11/01/2011 Authors: Yoo BK; He P; Lee S-J; Yun CC
  • Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.
    Mol Biol Cell Volume: 22 Page(s): 3812 - 3825
    10/01/2011 Authors: He P; Lee S-J; Lin S; Seidler U; Lang F; Fejes-Toth G; Naray-Fejes-Toth A; Yun CC
  • Role of SGKs in Glococorticoid-Mediated Regulation of NHE3
    Volume: 140 Page(s): S659 - S659
    05/01/2011 Authors: He P; Naray-Fejes-Toth A; Fejes-Toth G; Yun CC
  • LPA Induced Activation of NHE3 via I.PA5 Receptor is Apical EGF Receptor Dependent
    Volume: 140 Page(s): S132 - S132
    05/01/2011 Authors: Yoo BK; He P; Yun CC
  • The Differential Role of SGK3 from SGK1 and SGK2 in Activation of NHE3 by Glucocorticoid
    Volume: 25
    04/01/2011 Authors: He P; Lang F; Yun C
  • Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II.
    J Biol Chem Volume: 285 Page(s): 27869 - 27878
    09/03/2010 Authors: He P; Klein J; Yun CC
  • Angiotensin II-induced stimulation of NHE3 is dependent on IRBIT and CaMKII
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: He P; Yun C
  • Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.
    Gastroenterology Volume: 138 Page(s): 649 - 658
    02/01/2010 Authors: Lin S; Yeruva S; He P; Singh AK; Zhang H; Chen M; Lamprecht G; de Jonge HR; Tse M; Donowitz M
  • Up-regulation of circadian clock gene Period 2 in the prostate mesenchymal cells during flutamide-induced apoptosis.
    Mol Cell Biochem Volume: 335 Page(s): 37 - 45
    02/01/2010 Authors: Yoshida K; He P-J; Yamauchi N; Hashimoto S; Hattori M-A
  • Mechanisms of the regulation of the intestinal Na+/H+ exchanger NHE3.
    J Biomed Biotechnol Volume: 2010 Page(s): 238080
    01/01/2010 Authors: He P; Yun CC
  • Progesterone, but not estradiol, synchronizes circadian oscillator in the uterus endometrial stromal cells.
    Mol Cell Biochem Volume: 324 Page(s): 31 - 38
    04/01/2009 Authors: Hirata M; He P-J; Shibuya N; Uchikawa M; Yamauchi N; Hashimoto S; Hattori M-A
  • Sodium/bicarbonate cotransporter NBCn1/slc4a7 increases cytotoxicity in magnesium depletion in primary cultures of hippocampal neurons.
    Eur J Neurosci Volume: 29 Page(s): 437 - 446
    02/01/2009 Authors: Cooper DS; Yang HS; He P; Kim E; Rajbhandari I; Yun CC; Choi I
  • IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3 activity in response to calcium.
    J Biol Chem Volume: 283 Page(s): 33544 - 33553
    11/28/2008 Authors: He P; Zhang H; Yun CC
  • LPA stimulates NHE3 activity via LPA5 receptor
    GASTROENTEROLOGY Volume: 134 Page(s): A404 - A404
    04/01/2008 Authors: He P; Lin S; Zhang H; Wang D; Yun CC
  • Synchronization of circadian clockwork in the rat ovarian follicular cells during folliculogenesis and luteinization
    Page(s): 310 - 311
    01/01/2008 Authors: Yoshida K; He P-J; Hirata M; Aramaki S; Yamauchi N; Hashimoto S; Hattori M-A
  • Steroid hormone regulation of circadian clockwork system in the rat uterus stromal cells
    Page(s): 284 - 284
    01/01/2008 Authors: Hirata M; He P-J; Yoshida K; Aramaki S; Yamauchi N; Hashimo-To S; Hattori M-A
  • Effects of tumor necrosis factor-alpha on cell proliferation, prostaglandins and matrix-metalloproteinases production in rat endometrial stromal cells cultured in vitro.
    J Exp Zool A Ecol Genet Physiol Volume: 307 Page(s): 699 - 707
    12/01/2007 Authors: Gamo T; Yamauchi N; Nishimura K; Watanabe R; Matsumoto K; Oozono S; Kubota K; He P-J; Soh T; Hattori M-A
  • Up-regulation of Per1 expression by estradiol and progesterone in the rat uterus.
    J Endocrinol Volume: 194 Page(s): 511 - 519
    09/01/2007 Authors: He P-J; Hirata M; Yamauchi N; Hattori M-A
  • Gonadotropic regulation of circadian clockwork in rat granulosa cells.
    Mol Cell Biochem Volume: 302 Page(s): 111 - 118
    08/01/2007 Authors: He P-J; Hirata M; Yamauchi N; Hashimoto S; Hattori M-A
  • The disruption of circadian clockwork in differentiating cells from rat reproductive tissues as identified by in vitro real-time monitoring system.
    J Endocrinol Volume: 193 Page(s): 413 - 420
    06/01/2007 Authors: He P-J; Hirata M; Yamauchi N; Hashimoto S; Hattori M-A
  • Progesterone-dependent and -independent expression of the multidrug resistance type I gene in porcine granulosa cells.
    Mol Cell Biochem Volume: 298 Page(s): 179 - 186
    04/01/2007 Authors: Fukuda H; He PJ; Yokota K; Soh T; Yamauchi N; Hattori M-A
  • Development of a rat endometrial spheroid as a model for the analysis of endometrial functions
    REPRODUCTION FERTILITY AND DEVELOPMENT Volume: 19 Page(s): 312 - 313
    01/01/2007 Authors: Nishimura K; Oozono S; Urata H; He P; Soh T; Yamauchi N; Hattori M-A
  • Real-time monitoring of cAMP response element binding protein signaling in porcine granulosa cells modulated by ovarian factors.
    Mol Cell Biochem Volume: 290 Page(s): 177 - 184
    10/01/2006 Authors: He PJ; Fujimoto Y; Yamauchi N; Hattori M-A
  • FSH interference with the circadian circuit of clock system in granulosa cells.
    Page(s): 96 - 96
    01/01/2006 Authors: He P; Hirata M; Yamauchi N; Hattori M-A; Hashimoto S
  • Progesterone dependent and independent regulation of MDR1 expression in porcine granulosa cells.
    Page(s): 173 - 173
    01/01/2006 Authors: Fukuda H; He PJ; Soh T; Yamauchi N; Hattori M-A
  • Endogenous DNA damage and mutational profiles induced by oxyradical overload diseases in humans
    Volume: 197 Page(s): 154 - 154
    06/15/2004 Authors: Hussain SP; He PJ; Mechanic L; Hagiwara N; Harris CC
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