School of Medicine Homepage
Emory University Shield
  • About
    • Our Vision
    • Academic Departments
    • Our Leadership
    • Health Care Partnerships
    • Diversity, Equity, & Inclusion
    • Location
    • Supporting Our People
    • Our Faculty
    • History
    • News
    • Events
    • Contact Us
  • Education
    • Degree and Certificate Programs
    • Academic Departments
    • Residents & Fellows
    • Postdoctoral Training
    • Continuing Medical Education
    • Admissions
    • Cost and Financial Aid
    • Student Resources
  • Research
    • Research Innovation
    • Conducting Research
    • Core Facilities
    • Research Centers
    • Research Training
    • Academic Departments
    • Find a Researcher
    • Research News
  • Clinical Experience
    • Where We Work
    • Caring for a Diverse Population
    • Faculty Clinical Experience
    • Advanced Patient Care
    • Academic Departments
    • Community Learning
  • Giving
  • Directory

Directory section navigation

  • Faculty Profiles

Emory University School of Medicine

  • About
    • Sub link
      Our Vision
    • Sub link
      Academic Departments
    • Sub link
      Our Leadership
    • Sub link
      Health Care Partnerships
    • Sub link
      Diversity, Equity, & Inclusion
    • Sub link
      Location
    • Sub link
      Supporting Our People
    • Sub link
      Our Faculty
    • Sub link
      History
    • Sub link
      News
    • Sub link
      Events
    • Sub link
      Contact Us
  • Education
    • Sub link
      Degree and Certificate Programs
    • Sub link
      Academic Departments
    • Sub link
      Residents & Fellows
    • Sub link
      Postdoctoral Training
    • Sub link
      Continuing Medical Education
    • Sub link
      Admissions
    • Sub link
      Cost and Financial Aid
    • Sub link
      Student Resources
  • Research
    • Sub link
      Research Innovation
    • Sub link
      Conducting Research
    • Sub link
      Core Facilities
    • Sub link
      Research Centers
    • Sub link
      Research Training
    • Sub link
      Academic Departments
    • Sub link
      Find a Researcher
    • Sub link
      Research News
  • Clinical Experience
    • Sub link
      Where We Work
    • Sub link
      Caring for a Diverse Population
    • Sub link
      Faculty Clinical Experience
    • Sub link
      Advanced Patient Care
    • Sub link
      Academic Departments
    • Sub link
      Community Learning
  • Giving
  • Directory
  • Home School of Medicine Home
  • Directory

Profile

Ping Chen PhD

  • Department of Cell Biology
    Adjunct Associate Professor
  • (404) 727-1808
  • pchen2@emory.edu
Head shot of Ping Chen

Overview

Research Focus:
Planar cell polarity (PCP) is characterized with coordinated polarization of cells along the plane of the tissue. It is a driving force for the establishment of body axes during gastrulation. It also plays essential roles in neurulation and coordinating cellular polarity in many tissues/organs that are required for their functions.
The mammalian hearing and balance organs in the inner ear consist of highly stereotyped arrays of sensory hair cells and supporting cells. These sensory organs display distinct forms of PCP, essential for their balance and hearing functions. In addition, the motile cilia in the middle ear also display PCP, likely required for fluid and pathogen clearance. Defects in PCP cause developmental issues and in the functions of individual organs. We use the inner and middle ears as model systems to dissect the mechanisms regulating PCP and to investigate the molecular pathology of human diseases resulted from defects in human PCP genes.

Academic Appointment

  • Associate Professor, Department of Cell Biology, Emory University School of Medicine

Education

Degrees

  • PhD from University of Chicago
  • BS from Xiamen University
  • M.S from Shanghai Institute of Biochemistry, Academia Sinica

Research

Focus

  • Molecular and cellular mechanisms underlying the morphogenesis of the mammalian auditory sensory organ and planar cell polarity signaling in vertebrates

Publications

  • Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025.
    Nucleic Acids Res Volume: 53 Page(s): D30 - D44
    01/06/2025 Authors: CNCB-NGDC Members and Partners
  • In vivo assembly of complete eukaryotic nucleosomes and (H3-H4)-only non-canonical nucleosomal particles in the model bacterium Escherichia coli.
    Commun Biol Volume: 7 Page(s): 1510
    11/14/2024 Authors: Zhou X; Zhang N; Gong J; Zhang K; Chen P; Cheng X; Ye B-C; Zhao G; Jing X; Li X
  • Creating a bacterium that forms eukaryotic nucleosome core particles.
    Nat Commun Volume: 15 Page(s): 8283
    09/27/2024 Authors: Jing X; Zhang N; Zhou X; Chen P; Gong J; Zhang K; Wu X; Cai W; Ye B-C; Hao P
  • FACT mediates the depletion of macroH2A1.2 to expedite gene transcription.
    Mol Cell Volume: 84 Page(s): 3011 - 3025.e7
    08/22/2024 Authors: Ji D; Xiao X; Luo A; Fan X; Ma J; Wang D; Xia M; Ma L; Wang P-Y; Li W
  • Two C-terminal isoforms of Aplysia tachykinin-related peptide receptors exhibit phosphorylation-dependent and phosphorylation-independent desensitization mechanisms.
    J Biol Chem Volume: 300 Page(s): 107556
    08/01/2024 Authors: Mao R-T; Guo S-Q; Zhang G; Li Y-D; Xu J-P; Wang H-Y; Fu P; Liu C-P; Wu S-Q; Chen P
  • CropMetabolome: a comprehensive metabolome database for major crops cross eight categories.
    Plant J Volume: 119 Page(s): 1613 - 1626
    08/01/2024 Authors: Shi H; Zhu Y; Wu X; Jiang T; Li X; Liu J; Di Y; Chen F; Gao J; Xu X
  • Revealing Differential RNA Editing Specificity of Human ADAR1 and ADAR2 in Schizosaccharomyces pombe.
    Genes (Basel) Volume: 15
    07/09/2024 Authors: Zhang N; Chen P; Cui Z; Zhou X; Hao C; Xie B; Hao P; Ye B-C; Li X; Jing X
  • Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
    Nat Commun Volume: 15 Page(s): 3149
    04/11/2024 Authors: Fu J; Ling J; Li C-F; Tsai C-L; Yin W; Hou J; Chen P; Cao Y; Kang Y; Sun Y
  • H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction.
    Mol Cell Volume: 84 Page(s): 1191 - 1205.e7
    04/04/2024 Authors: Zhao J; Lan J; Wang M; Liu C; Fang Z; Song A; Zhang T; Wang L; Zhu B; Chen P
  • FOXA1 forms biomolecular condensates that unpack condensed chromatin to function as a pioneer factor.
    Mol Cell Volume: 84 Page(s): 244 - 260.e7
    01/18/2024 Authors: Ji D; Shao C; Yu J; Hou Y; Gao X; Wu Y; Wang L; Chen P
  • RefMetaPlant: a reference metabolome database for plants across five major phyla.
    Nucleic Acids Res Volume: 52 Page(s): D1614 - D1628
    01/05/2024 Authors: Shi H; Wu X; Zhu Y; Jiang T; Wang Z; Li X; Liu J; Zhang Y; Chen F; Gao J
  • Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses.
    Life Sci Alliance Volume: 6
    10/01/2023 Authors: Xia M; Wang B; Sun W; Ji D; Zhou H; Huang X; Yu M; Su Z; Chen P; Qu K
  • NFIB facilitates replication licensing by acting as a genome organizer.
    Nat Commun Volume: 14 Page(s): 5076
    08/21/2023 Authors: Zhang W; Wang Y; Liu Y; Liu C; Wang Y; He L; Cheng X; Peng Y; Xia L; Wu X
  • Histone H1 facilitates restoration of H3K27me3 during DNA replication by chromatin compaction.
    Nat Commun Volume: 14 Page(s): 4081
    07/10/2023 Authors: Liu C; Yu J; Song A; Wang M; Hu J; Chen P; Zhao J; Li G
  • Molecular Characterization of Two Wamide Neuropeptide Signaling Systems in Mollusk Aplysia.
    ACS Chem Neurosci Volume: 14 Page(s): 2425 - 2442
    07/05/2023 Authors: Wang H-Y; Yu K; Liu W-J; Jiang H-M; Guo S-Q; Xu J-P; Li Y-D; Chen P; Ding X-Y; Fu P
  • Human resident liver myeloid cells protect against metabolic stress in obesity.
    Nat Metab Volume: 5 Page(s): 1188 - 1203
    07/01/2023 Authors: Barreby E; Strunz B; Nock S; Naudet L; Shen JX; Johansson H; Snnerborg I; Ma J; Urgard E; Pallett LJ
  • Rab11a Is Essential for the Development and Integrity of the Stereocilia and Kinocilia in the Mammalian Organ of Corti.
    eNeuro Volume: 10
    06/01/2023 Authors: Knapp L; Sun H; Wang Y-M; Chen B-J; Lin X; Gao N; Chen P; Ren D
  • Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica.
    Sci Rep Volume: 13 Page(s): 7662
    05/11/2023 Authors: Fu P; Mei Y-S; Liu W-J; Chen P; Jin Q-C; Guo S-Q; Wang H-Y; Xu J-P; Zhang Y-C-F; Ding X-Y
  • H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation.
    Nat Commun Volume: 14 Page(s): 741
    02/10/2023 Authors: Luo A; Kong J; Chen J; Xiao X; Lan J; Li X; Liu C; Wang P-Y; Li G; Li W
  • Rack1 regulates cellular patterning and polarity in the mouse cochlea.
    Exp Cell Res Volume: 421 Page(s): 113387
    12/15/2022 Authors: Yu D; Deng D; Chen B; Sun H; Lyu J; Zhao Y; Chen P; Wu H; Ren D
  • Publisher Correction: Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma.
    Nat Commun Volume: 13 Page(s): 5830
    10/03/2022 Authors: Yang Y; Bolomsky A; Oellerich T; Chen P; Ceribelli M; Hupl B; Wright GW; Phelan JD; Huang DW; Lord JW
  • AI protein structure prediction-based modeling and mutagenesis of a protostome receptor and peptide ligands reveal key residues for their interaction.
    J Biol Chem Volume: 298 Page(s): 102440
    10/01/2022 Authors: Guo S-Q; Li Y-D; Chen P; Zhang G; Wang H-Y; Jiang H-M; Liu W-J; Xu J-P; Ding X-Y; Fu P
  • Oncogenic RAS commandeers amino acid sensing machinery to aberrantly activate mTORC1 in multiple myeloma.
    Nat Commun Volume: 13 Page(s): 5469
    09/17/2022 Authors: Yang Y; Bolomsky A; Oellerich T; Chen P; Ceribelli M; Hupl B; Wright GW; Phelan JD; Huang DW; Lord JW
  • Macrophage functional diversity in NAFLD - more than inflammation.
    Nat Rev Endocrinol Volume: 18 Page(s): 461 - 472
    08/01/2022 Authors: Barreby E; Chen P; Aouadi M
  • The Nab2 RNA-binding protein patterns dendritic and axonal projections through a planar cell polarity-sensitive mechanism.
    G3 (Bethesda) Volume: 12
    05/30/2022 Authors: Corgiat EB; List SM; Rounds JC; Yu D; Chen P; Corbett AH; Moberg KH
  • Exogenous expression of an allatotropin-related peptide receptor increased the membrane excitability in Aplysia neurons.
    Mol Brain Volume: 15 Page(s): 42
    05/09/2022 Authors: Zhang G; Guo S-Q; Yin S-Y; Yuan W-D; Chen P; Kim J-I; Wang H-Y; Zhou H-B; Susswein AJ; Kaang B-K
  • Targeted inhibition of Zika virus infection in human cells by CRISPR-Cas13b.
    Virus Res Volume: 312 Page(s): 198707
    04/15/2022 Authors: Chen P; Chen M; Chen Y; Jing X; Zhang N; Zhou X; Li X; Long G; Hao P
  • Direct cellular reprogramming enables development of viral T antigen-driven Merkel cell carcinoma in mice.
    J Clin Invest Volume: 132
    04/01/2022 Authors: Verhaegen ME; Harms PW; Van Goor JJ; Arche J; Patrick MT; Wilbert D; Zabawa H; Grachtchouk M; Liu C-J; Hu K
  • Probing the Effect of Ubiquitinated Histone on Mononucleosomes by Translocation Dynamics Study through Solid-State Nanopores.
    Nano Lett Volume: 22 Page(s): 888 - 895
    02/09/2022 Authors: Hu R; Liu C; Lu W; Wei G; Yu D; Li W; Chen P; Li G; Zhao Q
  • Molecular dynamic simulation analysis of SARS-CoV-2 spike mutations and evaluation of ACE2 from pets and wild animals for infection risk.
    Comput Biol Chem Volume: 96 Page(s): 107613
    02/01/2022 Authors: Chen P; Wang J; Xu X; Li Y; Zhu Y; Li X; Li M; Hao P
  • H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly.
    Nucleic Acids Res Volume: 50 Page(s): 833 - 846
    01/25/2022 Authors: Wang Y-Z; Liu C; Zhao J; Yu J; Luo A; Xiao X; Dou S-X; Ma L; Wang P-Y; Li M
  • HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs.
    Nucleic Acids Res Volume: 50 Page(s): 191 - 206
    01/11/2022 Authors: Yang Y; Zhang L; Xiong C; Chen J; Wang L; Wen Z; Yu J; Chen P; Xu Y; Jin J
  • Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
    Gastroenterology Volume: 161 Page(s): 1982 - 1997.e11
    12/01/2021 Authors: Azzimato V; Chen P; Barreby E; Morgantini C; Levi L; Vankova A; Jager J; Sulen A; Diotallevi M; Shen JX
  • Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.
    Nat Med Volume: 27 Page(s): 1941 - 1953
    11/01/2021 Authors: Li Q; Hagberg CE; Silva Cascales H; Lang S; Hyvnen MT; Salehzadeh F; Chen P; Alexandersson I; Terezaki E; Harms MJ
  • Scribble mutation disrupts convergent extension and apical constriction during mammalian neural tube closure.
    Dev Biol Volume: 478 Page(s): 59 - 75
    10/01/2021 Authors: Lesko AC; Keller R; Chen P; Sutherland A
  • A subset of Kupffer cells regulates metabolism through the expression of CD36.
    Immunity Volume: 54 Page(s): 2101 - 2116.e6
    09/14/2021 Authors: Blriot C; Barreby E; Dunsmore G; Ballaire R; Chakarov S; Ficht X; De Simone G; Andreata F; Fumagalli V; Guo W
  • Revealing the full biosphere structure and versatile metabolic functions in the deepest ocean sediment of the Challenger Deep.
    Genome Biol Volume: 22 Page(s): 207
    07/13/2021 Authors: Chen P; Zhou H; Huang Y; Xie Z; Zhang M; Wei Y; Li J; Ma Y; Luo M; Ding W
  • Revealing the Viral Community in the Hadal Sediment of the New Britain Trench.
    Genes (Basel) Volume: 12
    06/29/2021 Authors: Zhou H; Chen P; Zhang M; Chen J; Fang J; Li X
  • Structures and Functions of Chromatin Fibers.
    Annu Rev Biophys Volume: 50 Page(s): 95 - 116
    05/06/2021 Authors: Chen P; Li W; Li G
  • Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes.
    Nat Commun Volume: 12 Page(s): 2141
    04/09/2021 Authors: He B; Chen P; Zambrano S; Dabaghie D; Hu Y; Mller-Hackbarth K; Unnersj-Jess D; Korkut GG; Charrin E; Jeansson M
  • Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level.
    Biochemistry Volume: 60 Page(s): 494 - 499
    02/23/2021 Authors: Lu K; Liu C; Liu Y; Luo A; Chen J; Lei Z; Kong J; Xiao X; Zhang S; Wang Y-Z
  • Planar cell polarity governs the alignment of the nasopharyngeal epithelium in mammals.
    FEBS J Volume: 288 Page(s): 1027 - 1040
    02/01/2021 Authors: Luo W-W; Chen B-J; Wang Y-M; Yang J-M; Liu X; Yuan Y-S; Lin X; Chi F-L; Chen P; Ren D-D
  • Rab11a Regulates the Development of Cilia and Establishment of Planar Cell Polarity in Mammalian Vestibular Hair Cells.
    Front Mol Neurosci Volume: 14 Page(s): 762916
    01/01/2021 Authors: Chen B-J; Qian X-Q; Yang X-Y; Jiang T; Wang Y-M; Lyu J-H; Chi F-L; Chen P; Ren D-D
  • Molecular simulation of SARS-CoV-2 spike protein binding to pangolin ACE2 or human ACE2 natural variants reveals altered susceptibility to infection.
    J Gen Virol Volume: 101 Page(s): 921 - 924
    09/01/2020 Authors: Wang J; Xu X; Zhou X; Chen P; Liang H; Li X; Zhong W; Hao P
  • Single-cell RNA counting at allele and isoform resolution using Smart-seq3.
    Nat Biotechnol Volume: 38 Page(s): 708 - 714
    06/01/2020 Authors: Hagemann-Jensen M; Ziegenhain C; Chen P; Ramskld D; Hendriks G-J; Larsson AJM; Faridani OR; Sandberg R
  • Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin.
    Cell Res Volume: 30 Page(s): 393 - 407
    05/01/2020 Authors: Wang L; Hu M; Zuo M-Q; Zhao J; Wu D; Huang L; Wen Y; Li Y; Chen P; Bao X
  • Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission.
    Sci China Life Sci Volume: 63 Page(s): 457 - 460
    03/01/2020 Authors: Xu X; Chen P; Wang J; Feng J; Zhou H; Li X; Zhong W; Hao P
  • Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
    Sci Transl Med Volume: 12
    02/26/2020 Authors: Azzimato V; Jager J; Chen P; Morgantini C; Levi L; Barreby E; Sulen A; Oses C; Willerbrords J; Xu C
  • Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at the Single-Nucleosome Level.
    J Am Chem Soc Volume: 142 Page(s): 3340 - 3345
    02/19/2020 Authors: Xiao X; Liu C; Pei Y; Wang Y-Z; Kong J; Lu K; Ma L; Dou S-X; Wang P-Y; Li G
  • Author Correction: H2A.Z facilitates licensing and activation of early replication origins.
    Nature Volume: 578 Page(s): E8
    02/01/2020 Authors: Long H; Zhang L; Lv M; Wen Z; Zhang W; Chen X; Zhang P; Li T; Chang L; Jin C
  • Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors.
    Nat Commun Volume: 11 Page(s): 445
    01/23/2020 Authors: Wilson DH; Jarman EJ; Mellin RP; Wilson ML; Waddell SH; Tsokkou P; Younger NT; Raven A; Bhalla SR; Noll ATR
  • H2A.Z facilitates licensing and activation of early replication origins.
    Nature Volume: 577 Page(s): 576 - 581
    01/01/2020 Authors: Long H; Zhang L; Lv M; Wen Z; Zhang W; Chen X; Zhang P; Li T; Chang L; Jin C
  • Adaptor protein-3 complex is required for Vangl2 trafficking and planar cell polarity of the inner ear.
    Mol Biol Cell Volume: 30 Page(s): 2422 - 2434
    08/15/2019 Authors: Tower-Gilchrist C; Zlatic SA; Yu D; Chang Q; Wu H; Lin X; Faundez V; Chen P
  • Effects of simulated microgravity on the expression profiles of RNA during osteogenic differentiation of human bone marrow mesenchymal stem cells.
    Cell Prolif Volume: 52 Page(s): e12539
    03/01/2019 Authors: Li L; Zhang C; Chen J-L; Hong F-F; Chen P; Wang J-F
  • A Hemizygous Deletion Within the PGK1 Gene in Males with PGK1 Deficiency.
    JIMD Rep Volume: 45 Page(s): 105 - 110
    01/01/2019 Authors: Behlmann AM; Goyal NA; Yang X; Chen PH; Ankala A
  • Modelling BioNano optical data and simulation study of genome map assembly.
    Bioinformatics Volume: 34 Page(s): 3966 - 3974
    12/01/2018 Authors: Chen P; Jing X; Ren J; Cao H; Hao P; Li X
  • UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells.
    BMC Biol Volume: 16 Page(s): 110
    10/03/2018 Authors: Xiong C; Wen Z; Yu J; Chen J; Liu C-P; Zhang X; Chen P; Xu R-M; Li G
  • Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells.
    BMC Biol Volume: 16 Page(s): 107
    09/24/2018 Authors: Wang Y; Long H; Yu J; Dong L; Wassef M; Zhuo B; Li X; Zhao J; Wang M; Liu C
  • Space microgravity drives transdifferentiation of human bone marrow-derived mesenchymal stem cells from osteogenesis to adipogenesis.
    FASEB J Volume: 32 Page(s): 4444 - 4458
    08/01/2018 Authors: Zhang C; Li L; Jiang Y; Wang C; Geng B; Wang Y; Chen J; Liu F; Qiu P; Zhai G
  • Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level.
    Mol Cell Volume: 71 Page(s): 284 - 293.e4
    07/19/2018 Authors: Chen P; Dong L; Hu M; Wang Y-Z; Xiao X; Zhao Z; Yan J; Wang P-Y; Reinberg D; Li M
  • Junctional E-cadherin/p120-catenin Is Correlated with the Absence of Supporting Cells to Hair Cells Conversion in Postnatal Mice Cochleae.
    Front Mol Neurosci Volume: 11 Page(s): 20
    01/01/2018 Authors: Luo W-W; Wang X-W; Ma R; Chi F-L; Chen P; Cong N; Gu Y-Y; Ren D-D; Yang J-M
  • Afferent synaptogenesis between ectopic hair-cell-like cells and neurites of spiral ganglion induced by Atoh1 in mammals in vitro.
    Neuroscience Volume: 357 Page(s): 185 - 196
    08/15/2017 Authors: Luo W-W; Ma R; Cheng X; Yang X-Y; Han Z; Ren D-D; Chen P; Chi F-L; Yang J-M
  • BioNano Genome Map Resource for Oryza sativa ssp. japonica and indica and Its Application in Rice Genome Sequence Correction and Gap Filling.
    Mol Plant Volume: 10 Page(s): 895 - 898
    06/05/2017 Authors: Chen P; Jing X; Liao B; Zhu Y; Xu J; Liu R; Zhao Y; Li X
  • Cilia distribution and polarity in the epithelial lining of the mouse middle ear cavity.
    Sci Rep Volume: 7 Page(s): 45870
    03/30/2017 Authors: Luo W; Yi H; Taylor J; Li J-D; Chi F; Todd NW; Lin X; Ren D; Chen P
  • Establishment of planar cell polarity is coupled to regional cell cycle exit and cell differentiation in the mouse utricle.
    Sci Rep Volume: 7 Page(s): 43021
    02/23/2017 Authors: Yang X; Qian X; Ma R; Wang X; Yang J; Luo W; Chen P; Chi F; Ren D
  • Structure and Epigenetic Regulation of Chromatin Fibers.
    Cold Spring Harb Symp Quant Biol Volume: 82 Page(s): 25 - 35
    01/01/2017 Authors: Chen P; Li G
  • Induction of differentiation of human embryonic stem cells into functional hair-cell-like cells in the absence of stromal cells.
    Int J Biochem Cell Biol Volume: 81 Page(s): 208 - 222
    12/01/2016 Authors: Ding J; Tang Z; Chen J; Shi H; Chen J; Wang C; Zhang C; Li L; Chen P; Wang J
  • FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription.
    Mol Cell Volume: 64 Page(s): 120 - 133
    10/06/2016 Authors: Li W; Chen P; Yu J; Dong L; Liang D; Feng J; Yan J; Wang P-Y; Li Q; Zhang Z
  • Effects of genetic correction on the differentiation of hair cell-like cells from iPSCs with MYO15A mutation.
    Cell Death Differ Volume: 23 Page(s): 1347 - 1357
    08/01/2016 Authors: Chen J-R; Tang Z-H; Zheng J; Shi H-S; Ding J; Qian X-D; Zhang C; Chen J-L; Wang C-C; Li L
  • Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells.
    Stem Cells Transl Med Volume: 5 Page(s): 561 - 571
    05/01/2016 Authors: Tang Z-H; Chen J-R; Zheng J; Shi H-S; Ding J; Qian X-D; Zhang C; Chen J-L; Wang C-C; Li L
  • Spatial and Age-Dependent Hair Cell Generation in the Postnatal Mammalian Utricle.
    Mol Neurobiol Volume: 53 Page(s): 1601 - 1612
    04/01/2016 Authors: Gao Z; Kelly MC; Yu D; Wu H; Lin X; Chi F-L; Chen P
  • The GPSM2/LGN GoLoco motifs are essential for hearing.
    Mamm Genome Volume: 27 Page(s): 29 - 46
    02/01/2016 Authors: Bhonker Y; Abu-Rayyan A; Ushakov K; Amir-Zilberstein L; Shivatzki S; Yizhar-Barnea O; Elkan-Miller T; Tayeb-Fligelman E; Kim SM; Landau M
  • SOX6 and PDCD4 enhance cardiomyocyte apoptosis through LPS-induced miR-499 inhibition.
    Apoptosis Volume: 21 Page(s): 174 - 183
    02/01/2016 Authors: Jia Z; Wang J; Shi Q; Liu S; Wang W; Tian Y; Lu Q; Chen P; Ma K; Zhou C
  • Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome.
    Elife Volume: 5
    01/26/2016 Authors: Fang Q; Chen P; Wang M; Fang J; Yang N; Li G; Xu R-M
  • Induction of Functional Hair-Cell-Like Cells from Mouse Cochlear Multipotent Cells.
    Stem Cells Int Volume: 2016 Page(s): 8197279
    01/01/2016 Authors: Liu Q; Shen Y; Chen J; Ding J; Tang Z; Zhang C; Chen J; Li L; Chen P; Wang J
  • GAA triplet-repeats cause nucleosome depletion in the human genome.
    Genomics Volume: 106 Page(s): 88 - 95
    08/01/2015 Authors: Zhao H; Xing Y; Liu G; Chen P; Zhao X; Li G; Cai L
  • Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N.
    Genes Dev Volume: 29 Page(s): 1058 - 1073
    05/15/2015 Authors: Fang J; Liu Y; Wei Y; Deng W; Yu Z; Huang L; Teng Y; Yao T; You Q; Ruan H
  • Identification of stage-specific markers during differentiation of hair cells from mouse inner ear stem cells or progenitor cells in vitro.
    Int J Biochem Cell Biol Volume: 60 Page(s): 99 - 111
    03/01/2015 Authors: Liu Q; Chen J; Gao X; Ding J; Tang Z; Zhang C; Chen J; Li L; Chen P; Wang J
  • Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeres.
    Dev Cell Volume: 32 Page(s): 68 - 81
    01/12/2015 Authors: Yu Z; Zhou X; Wang W; Deng W; Fang J; Hu H; Wang Z; Li S; Cui L; Shen J
  • Loss of adaptor protein-3 complex leads to defective Vangl2 trafficking and disruption of planar cell polarity and convergent extension
    Volume: 25
    12/01/2014 Authors: Tower-Gilchrist CD; Zlatic S; Chang Q; Faundez V; Lin E; Chen P
  • Armcx1, a potential gene of planar cell polarity regulation.
    Volume: 25
    12/01/2014 Authors: Knapp L; Chen P
  • De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome.
    Cell Res Volume: 24 Page(s): 1370 - 1373
    11/01/2014 Authors: Yuan Y; Zhang J; Chang Q; Zeng J; Xin F; Wang J; Zhu Q; Wu J; Lu J; Guo W
  • Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.
    Dev Biol Volume: 395 Page(s): 62 - 72
    11/01/2014 Authors: Jones C; Qian D; Kim SM; Li S; Ren D; Knapp L; Sprinzak D; Avraham KB; Matsuzaki F; Chi F
  • New insights into the helical structure of 30-nm chromatin fibers.
    Protein Cell Volume: 5 Page(s): 489 - 491
    07/01/2014 Authors: Chen P; Zhu P; Li G
  • Molecular mechanisms and potentials for differentiating inner ear stem cells into sensory hair cells.
    Dev Biol Volume: 390 Page(s): 93 - 101
    06/15/2014 Authors: Liu Q; Chen P; Wang J
  • Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetranucleosomal units.
    Science Volume: 344 Page(s): 376 - 380
    04/25/2014 Authors: Song F; Chen P; Sun D; Wang M; Dong L; Liang D; Xu R-M; Zhu P; Li G
  • Dynamics of histone variant H3.3 and its coregulation with H2A.Z at enhancers and promoters.
    Nucleus Volume: 5 Page(s): 21 - 27
    01/01/2014 Authors: Chen P; Wang Y; Li G
  • Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice.
    Dev Dyn Volume: 242 Page(s): 1454 - 1465
    12/01/2013 Authors: Ren D-D; Kelly M; Kim SM; Grimsley-Myers CM; Chi F-L; Chen P
  • Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases.
    J Biol Chem Volume: 288 Page(s): 30832 - 30842
    10/25/2013 Authors: Yuan G; Ma B; Yuan W; Zhang Z; Chen P; Ding X; Feng L; Shen X; Chen S; Li G
  • H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin.
    Genes Dev Volume: 27 Page(s): 2109 - 2124
    10/01/2013 Authors: Chen P; Zhao J; Wang Y; Wang M; Long H; Liang D; Huang L; Wen Z; Li W; Li X
  • Histone variants in development and diseases.
    J Genet Genomics Volume: 40 Page(s): 355 - 365
    07/20/2013 Authors: Chen P; Zhao J; Li G
  • Planar cell polarity protein Vangl2 traffics through adaptor protein complex-mediated endosomal pathways
    MOLECULAR BIOLOGY OF THE CELL Volume: 24
    01/01/2013 Authors: Tower-Gilchrist CD; Zlatic SA; Faundez V; Chen P
  • Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX.
    Nat Struct Mol Biol Volume: 19 Page(s): 1287 - 1292
    12/01/2012 Authors: Liu C-P; Xiong C; Wang M; Yu Z; Yang N; Chen P; Zhang Z; Li G; Xu R-M
  • Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo.
    J Neurosci Volume: 32 Page(s): 6699 - 6710
    05/09/2012 Authors: Kelly MC; Chang Q; Pan A; Lin X; Chen P
  • Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin.
    Development Volume: 139 Page(s): 968 - 978
    03/01/2012 Authors: Chacon-Heszele MF; Ren D; Reynolds AB; Chi F; Chen P
  • Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger.
    Cell Res Volume: 21 Page(s): 1379 - 1382
    09/01/2011 Authors: Wang C; Shen J; Yang Z; Chen P; Zhao B; Hu W; Lan W; Tong X; Wu H; Li G
  • Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase.
    Cell Res Volume: 21 Page(s): 1172 - 1181
    08/01/2011 Authors: Li B-Z; Huang Z; Cui Q-Y; Song X-H; Du L; Jeltsch A; Chen P; Li G; Li E; Xu G-L
  • Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity.
    Proc Natl Acad Sci U S A Volume: 108 Page(s): 2264 - 2269
    02/08/2011 Authors: Li S; Esterberg R; Lachance V; Ren D; Radde-Gallwitz K; Chi F; Parent J-L; Fritz A; Chen P
  • Structural insights into the two sequential folding transition states of the PB1 domain of NBR1 from value analysis and biased molecular dynamics simulations.
    Biochemistry Volume: 50 Page(s): 125 - 135
    01/11/2011 Authors: Chen P; Evans C-L; Hirst JD; Searle MS
  • Dynamics of the higher-order structure of chromatin.
    Protein Cell Volume: 1 Page(s): 967 - 971
    11/01/2010 Authors: Chen P; Li G
  • Atoh1 regulates cellular patterning through cell fate specification and cell-cycle control in the mammalian cochlea
    Volume: 344 Page(s): 455 - 455
    08/01/2010 Authors: Kelly MC; Chen PH
  • Line up and listen: Planar cell polarity regulation in the mammalian inner ear.
    Semin Cell Dev Biol Volume: 20 Page(s): 978 - 985
    10/01/2009 Authors: Rida PCG; Chen P
  • Development of form and function in the mammalian cochlea.
    Curr Opin Neurobiol Volume: 19 Page(s): 395 - 401
    08/01/2009 Authors: Kelly MC; Chen P
  • Dissecting the role for ciliary genes in intrinsic cell polarity during PCP signaling
    Volume: 331 Page(s): 449 - 450
    07/15/2009 Authors: Chacon-Heszele MF; Anderson R; Chen P
  • Mouse models for dissecting vertebrate planar cell polarity signaling in the inner ear.
    Brain Res Volume: 1277 Page(s): 130 - 140
    06/24/2009 Authors: Chacon-Heszele MF; Chen P
  • Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases.
    Neural Dev Volume: 4 Page(s): 7
    02/11/2009 Authors: Vivancos V; Chen P; Spassky N; Qian D; Dabdoub A; Kelley M; Studer M; Guthrie S
  • Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
    PLoS Genet Volume: 4 Page(s): e1000259
    11/01/2008 Authors: Etheridge SL; Ray S; Li S; Hamblet NS; Lijam N; Tsang M; Greer J; Kardos N; Wang J; Sussman DJ
  • Sequential barriers and an obligatory metastable intermediate define the apparent two-state folding pathway of the ubiquitin-like PB1 domain of NBR1.
    J Mol Biol Volume: 376 Page(s): 1463 - 1477
    03/07/2008 Authors: Chen P; Long J; Searle MS
  • Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development.
    BMC Dev Biol Volume: 8 Page(s): 20
    02/26/2008 Authors: Li S; Mark S; Radde-Gallwitz K; Schlisner R; Chin MT; Chen P
  • Primary cilia in planar cell polarity regulation of the inner ear.
    Curr Top Dev Biol Volume: 85 Page(s): 197 - 224
    01/01/2008 Authors: Jones C; Chen P
  • Ciliary proteins link basal body polarization to planar cell polarity regulation.
    Nat Genet Volume: 40 Page(s): 69 - 77
    01/01/2008 Authors: Jones C; Roper VC; Foucher I; Qian D; Banizs B; Petit C; Yoder BK; Chen P
  • Analysis of connexin subunits required for the survival of vestibular hair cells.
    J Comp Neurol Volume: 504 Page(s): 499 - 507
    10/10/2007 Authors: Qu Y; Tang W; Dahlke I; Ding D; Salvi R; Shl G; Willecke K; Chen P; Lin X
  • Wnt5a functions in planar cell polarity regulation in mice.
    Dev Biol Volume: 306 Page(s): 121 - 133
    06/01/2007 Authors: Qian D; Jones C; Rzadzinska A; Mark S; Zhang X; Steel KP; Dai X; Chen P
  • Planar cell polarity signaling in vertebrates.
    Bioessays Volume: 29 Page(s): 120 - 132
    02/01/2007 Authors: Jones C; Chen P
  • Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness.
    Proc Natl Acad Sci U S A Volume: 104 Page(s): 1337 - 1341
    01/23/2007 Authors: Ahmad S; Tang W; Chang Q; Qu Y; Hibshman J; Li Y; Shl G; Willecke K; Chen P; Lin X
  • Shaping the mammalian auditory sensory organ by the planar cell polarity pathway.
    Int J Dev Biol Volume: 51 Page(s): 535 - 547
    01/01/2007 Authors: Kelly M; Chen P
  • Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear.
    Dev Dyn Volume: 235 Page(s): 1689 - 1700
    06/01/2006 Authors: Qian D; Radde-Gallwitz K; Kelly M; Tyrberg B; Kim J; Gao W-Q; Chen P
  • Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.
    Development Volume: 133 Page(s): 1767 - 1778
    05/01/2006 Authors: Wang J; Hamblet NS; Mark S; Dickinson ME; Brinkman BC; Segil N; Fraser SE; Chen P; Wallingford JB; Wynshaw-Boris A
  • Connexin29 is highly expressed in cochlear Schwann cells, and it is required for the normal development and function of the auditory nerve of mice.
    J Neurosci Volume: 26 Page(s): 1991 - 1999
    02/15/2006 Authors: Tang W; Zhang Y; Chang Q; Ahmad S; Dahlke I; Yi H; Chen P; Paul DL; Lin X
  • The Primary Cilium in Planar Cell Polarity Signaling in the Organ of Corti
    MOLECULAR BIOLOGY OF THE CELL Volume: 17
    01/01/2006 Authors: Jones C; Banizs B; Qian D; Yoder BK; Chen P
  • Gap junction-mediated intercellular biochemical coupling in cochlear supporting cells is required for normal cochlear functions.
    Proc Natl Acad Sci U S A Volume: 102 Page(s): 15201 - 15206
    10/18/2005 Authors: Zhang Y; Tang W; Ahmad S; Sipp JA; Chen P; Lin X
  • Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.
    Nat Genet Volume: 37 Page(s): 980 - 985
    09/01/2005 Authors: Wang J; Mark S; Zhang X; Qian D; Yoo S-J; Radde-Gallwitz K; Zhang Y; Lin X; Collazo A; Wynshaw-Boris A
  • Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts.
    Am J Physiol Cell Physiol Volume: 288 Page(s): C613 - C623
    03/01/2005 Authors: Sun J; Ahmad S; Chen S; Tang W; Zhang Y; Chen P; Lin X
  • Acid-sensing ion channel 2 contributes a major component to acid-evoked excitatory responses in spiral ganglion neurons and plays a role in noise susceptibility of mice.
    J Neurosci Volume: 24 Page(s): 10167 - 10175
    11/10/2004 Authors: Peng B-G; Ahmad S; Chen S; Chen P; Price MP; Lin X
  • Expression of Islet1 marks the sensory and neuronal lineages in the mammalian inner ear.
    J Comp Neurol Volume: 477 Page(s): 412 - 421
    09/27/2004 Authors: Radde-Gallwitz K; Pan L; Gan L; Lin X; Segil N; Chen P
  • Coupling of polarized extension to the establishment of planar cell polarity in the developing mammalian auditory sensory organ.
    Volume: 271 Page(s): 557 - 557
    07/15/2004 Authors: Chen P; Segil N; Collazo A; Lin X
  • Group I metabotropic glutamate receptors in spiral ganglion neurons contribute to excitatory neurotransmissions in the cochlea.
    Neuroscience Volume: 123 Page(s): 221 - 230
    01/01/2004 Authors: Peng BG; Li QX; Ren TY; Ahmad S; Chen SP; Chen P; Lin X
  • Math1-driven GFP expression in the developing nervous system of transgenic mice.
    Gene Expr Patterns Volume: 3 Page(s): 389 - 395
    08/01/2003 Authors: Lumpkin EA; Collisson T; Parab P; Omer-Abdalla A; Haeberle H; Chen P; Doetzlhofer A; White P; Groves A; Segil N
  • Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d.
    Nat Cell Biol Volume: 5 Page(s): 422 - 426
    05/01/2003 Authors: Chen P; Zindy F; Abdala C; Liu F; Li X; Roussel MF; Segil N
  • The role of Math1 in inner ear development: Uncoupling the establishment of the sensory primordium from hair cell fate determination.
    Development Volume: 129 Page(s): 2495 - 2505
    05/01/2002 Authors: Chen P; Johnson JE; Zoghbi HY; Segil N
  • Expression patterns of aquaporins in the inner ear: evidence for concerted actions of multiple types of aquaporins to facilitate water transport in the cochlea.
    Hear Res Volume: 165 Page(s): 85 - 95
    03/01/2002 Authors: Huang D; Chen P; Chen S; Nagura M; Lim DJ; Lin X
  • Activation of metabotropic GABAB receptors inhibited glutamate responses in spiral ganglion neurons of mice.
    Neuroreport Volume: 11 Page(s): 957 - 961
    04/07/2000 Authors: Lin X; Chen S; Chen P
  • p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti.
    Development Volume: 126 Page(s): 1581 - 1590
    04/01/1999 Authors: Chen P; Segil N
  • Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly.
    Cell Volume: 86 Page(s): 961 - 972
    09/20/1996 Authors: Chen P; Hochstrasser M
  • Biogenesis, structure and function of the yeast 20S proteasome.
    EMBO J Volume: 14 Page(s): 2620 - 2630
    06/01/1995 Authors: Chen P; Hochstrasser M
  • The DOA pathway: studies on the functions and mechanisms of ubiquitin-dependent protein degradation in the yeast Saccharomyces cerevisiae.
    Cold Spring Harb Symp Quant Biol Volume: 60 Page(s): 503 - 513
    01/01/1995 Authors: Hochstrasser M; Papa FR; Chen P; Swaminathan S; Johnson P; Stillman L; Amerik AY; Li SJ
  • Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor.
    Cell Volume: 74 Page(s): 357 - 369
    07/30/1993 Authors: Chen P; Johnson P; Sommer T; Jentsch S; Hochstrasser M
  • Evidence that the protein components of bovine erythrocyte green heme binding protein and flavin reductase are identical.
    Biochem Biophys Res Commun Volume: 178 Page(s): 315 - 321
    07/15/1991 Authors: Quandt KS; Xu F; Chen P; Hultquist DE
Read more publications Fewer publications
Directory
  • Faculty Profiles
Emory University Homepage

Contact & Location

Emory University School of Medicine
100 Woodruff Circle
Atlanta, GA  30322 USA
  • Contact Us
  • Maps & Directions
  • Careers

Information For

  • Alumni
  • Faculty & Staff
  • Patients
  • Residents & Fellows
  • Students
Support the School of Medicine School of Medicine Intranet
facebook facebook twitter twitter linkedin linkedin instagram instagram youtube youtube
© 2025 Emory University
  • Privacy Policy
  • Emergency Information
  • EEO Employer-Disability/Veteran Statements