Guy Benian

Department of Pathology and Laboratory Medicine
Professor

(404) 727-5953
pathgb@emory.edu

Emory University
Pathology
Whitehead Biomedical Research Building 105E

Academic Appointment

Professor of Cell Biology, Emory University School of Medicine
Professor of Pathology, Emory University School of Medicine

Education

Degrees

MD from Wayne State University School of Medicine
BS from University of Michigan

Research

Focus

Myofibril assembly and maintenance in the model genetic system, Caenorhabditis elegans; focus on the functions and structures of giant multi-domain proteins, and the mechanism by which myofibrils are attached to the muscle cell membrane and transmit force.

Publications

Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function.
Commun Biol Volume: 7 Page(s): 1342
10/17/2024 Authors: Matsunaga Y; Qadota H; Ghazal N; Lesanpezeshki L; Dorendorf T; Moody JC; Ahier A; Matheny CJ; Vanapalli SA; Zuryn S
The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging.
Mol Biol Cell Volume: 35 Page(s): ar98
07/01/2024 Authors: Matheny CJ; Qadota H; Bailey AO; Valdebenito-Silva S; Oberhauser AF; Benian GM
The RhoGAP RRC-1 is required for the assembly or stability of integrin adhesion complexes and is a member of the PIX pathway in muscle.
Mol Biol Cell Volume: 35 Page(s): ar58
04/01/2024 Authors: Moody JC; Qadota H; Benian GM
FARL-11 (STRIP1/2) is required for sarcomere and sarcoplasmic reticulum organization in C. elegans.
Mol Biol Cell Volume: 34 Page(s): ar86
08/01/2023 Authors: Martin SCT; Qadota H; Oberhauser AF; Hardin J; Benian GM
FARL-11 (STRIP1/2) is Required for Sarcomere and Sarcoplasmic Reticulum Organization in C. elegans.
bioRxiv
03/06/2023 Authors: Martin SCT; Qadota H; Oberhauser AF; Hardin J; Benian GM
Genetic analysis suggests a surface of PAT-4 (ILK) that interacts with UNC-112 (kindlin).
G3 (Bethesda) Volume: 12
07/06/2022 Authors: Qadota H; McPherson A; Corbitt R; Dackowski EK; Matsunaga Y; Oberhauser AF; Benian GM
Neuronal C/EBP/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression.
Sci Adv Volume: 8 Page(s): eabj8658
04/01/2022 Authors: Xia Y; Qadota H; Wang Z-H; Liu P; Liu X; Ye KX; Matheny CJ; Berglund K; Yu SP; Drake D
Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group-like antigens.
J Biol Chem Volume: 298 Page(s): 101704
04/01/2022 Authors: Blenda AV; Kamili NA; Wu S-C; Abel WF; Ayona D; Gerner-Smidt C; Ho AD; Benian GM; Cummings RD; Arthur CM
Mutations in conserved residues of the myosin chaperone UNC-45 result in both reduced stability and chaperoning activity.
Protein Sci Volume: 30 Page(s): 2221 - 2232
11/01/2021 Authors: Moncrief T; Matheny CJ; Gaziova I; Miller JM; Qadota H; Benian GM; Oberhauser AF
Conformational changes in twitchin kinase in vivo revealed by FRET imaging of freely moving C. elegans.
Elife Volume: 10
09/27/2021 Authors: Porto D; Matsunaga Y; Franke B; Williams RM; Qadota H; Mayans O; Benian GM; Lu H
Investigating the correlation of muscle function tests and sarcomere organization in C. elegans.
Skelet Muscle Volume: 11 Page(s): 20
08/13/2021 Authors: Lesanpezeshki L; Qadota H; Darabad MN; Kashyap K; Lacerda CMR; Szewczyk NJ; Benian GM; Vanapalli SA
Missense mutation of a conserved residue in UNC-112 (kindlin) eliminates binding to PAT-4 (ILK).
MicroPubl Biol Volume: 2021
01/01/2021 Authors: Qadota H; Oberhauser AF; Benian GM
Genetic analysis of the interaction between the N- and C-terminal halves of UNC-112 (kindlin).
MicroPubl Biol Volume: 2020
12/17/2020 Authors: Qadota H; Luo Y; Oberhauser AF; Benian GM
The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells.
Nat Commun Volume: 11 Page(s): 5010
10/06/2020 Authors: Moody JC; Qadota H; Reedy AR; Okafor CD; Shanmugan N; Matsunaga Y; Christian CJ; Ortlund EA; Benian GM
Animal models of sarcopenia.
Aging Cell Volume: 19 Page(s): e13223
10/01/2020 Authors: Christian CJ; Benian GM
Mutational Analysis of the Structure and Function of the Chaperoning Domain of UNC-45B.
Biophys J Volume: 119 Page(s): 780 - 791
08/18/2020 Authors: Gaziova I; Moncrief T; Christian CJ; Villarreal M; Powell S; Lee H; Qadota H; White MA; Benian GM; Oberhauser AF
A Region of UNC-89 (Obscurin) Lying between Two Protein Kinase Domains Is a Highly Elastic Spring Required for Proper Sarcomere Organization.
J Mol Biol Volume: 432 Page(s): 4799 - 4814
08/07/2020 Authors: Qadota H; Moody JC; Lesanpezeshki L; Moncrief T; Kitzler D; Bhat PD; Vanapalli SA; Oberhauser AF; Benian GM
From worms to fish to mice.
Elife Volume: 9
05/06/2020 Authors: Benian GM; Choo HJ
PIX-1, A RHO-GEF, THAT DIRECTS SITE SPECIFIC ASSEMBLY OF INTEGRIN ADHESION COMPLEXES IN STRIATED MUSCLE.
Volume: 29
12/15/2018 Authors: Moody JC; Qadota H; Reedy AR; Shanmugan N; Lesanpezeshki L; Vanapalli S; Matsunaga Y; Benian GM
Protein phosphatase 2A is crucial for sarcomere organization in Caenorhabditis elegans striated muscle.
Mol Biol Cell Volume: 29 Page(s): 2084 - 2097
08/15/2018 Authors: Qadota H; Matsunaga Y; Bagchi P; Lange KI; Carrier KJ; Pols WV; Swartzbaugh E; Wilson KJ; Srayko M; Pallas DC
Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase.
J Mol Biol Volume: 430 Page(s): 793 - 805
03/16/2018 Authors: Williams RM; Franke B; Wilkinson M; Fleming JR; Rigden DJ; Benian GM; Eyers PA; Mayans O
Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes.
Mol Biol Cell Volume: 28 Page(s): 3621 - 3633
12/01/2017 Authors: Loveless T; Qadota H; Benian GM; Hardin J
High-resolution imaging of muscle attachment structures in Caenorhabditis elegans.
Cytoskeleton (Hoboken) Volume: 74 Page(s): 426 - 442
11/01/2017 Authors: Qadota H; Matsunaga Y; Nguyen KCQ; Mattheyses A; Hall DH; Benian GM
Indoles from commensal bacteria extend healthspan.
Proc Natl Acad Sci U S A Volume: 114 Page(s): E7506 - E7515
09/05/2017 Authors: Sonowal R; Swimm A; Sahoo A; Luo L; Matsunaga Y; Wu Z; Bhingarde JA; Ejzak EA; Ranawade A; Qadota H
Twitchin kinase inhibits muscle activity.
Mol Biol Cell Volume: 28 Page(s): 1591 - 1600
06/15/2017 Authors: Matsunaga Y; Hwang H; Franke B; Williams R; Penley M; Qadota H; Yi H; Morran LT; Lu H; Mayans O
Development, structure, and maintenance of C. elegans body wall muscle.
WormBook Volume: 2017 Page(s): 1 - 59
04/13/2017 Authors: Gieseler K; Qadota H; Benian GM
MUTATIONAL AND BIOCHEMICAL ANALYSIS OF THE DUAL KINASE REGION OF UNC-89 (OBSCURIN).
Volume: 28
01/01/2017 Authors: Matsunaga Y; Qadota H; Moody JC; Kwong JQ; Benian GM
IDENTIFICATION OF A RHO-GEF THAT DIRECTS SITE-SPECIFIC ASSEMBLY OF INTEGRIN ADHESION COMPLEXES IN STRIATED MUSCLE.
Volume: 28
01/01/2017 Authors: Moody JC; Qadota H; Shanmugam N; Reedy AR; Benian GM
The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle.
Mol Biol Cell Volume: 27 Page(s): 1606 - 1620
05/15/2016 Authors: Qadota H; Mayans O; Matsunaga Y; McMurry JL; Wilson KJ; Kwon GE; Stanford R; Deehan K; Tinley TL; Ngwa VM
Diapause is associated with a change in the polarity of secretion of insulin-like peptides.
Nat Commun Volume: 7 Page(s): 10573
02/03/2016 Authors: Matsunaga Y; Honda Y; Honda S; Iwasaki T; Qadota H; Benian GM; Kawano T
Muscle contraction phenotypic analysis enabled by optogenetics reveals functional relationships of sarcomere components in Caenorhabditis elegans.
Sci Rep Volume: 6 Page(s): 19900
01/29/2016 Authors: Hwang H; Barnes DE; Matsunaga Y; Benian GM; Ono S; Lu H
Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.
Mol Biol Cell Volume: 26 Page(s): 2096 - 2111
06/01/2015 Authors: Matsunaga Y; Qadota H; Furukawa M; Choe HH; Benian GM
Titin and obscurin: giants holding hands and discovery of a new Ig domain subset.
J Mol Biol Volume: 427 Page(s): 707 - 714
02/27/2015 Authors: Benian GM; Mayans O
On-demand optical immobilization of Caenorhabditis elegans for high-resolution imaging and microinjection.
Lab Chip Volume: 14 Page(s): 3498 - 3501
09/21/2014 Authors: Hwang H; Krajniak J; Matsunaga Y; Benian GM; Lu H
Suppressor mutations suggest a surface on PAT-4 (Integrin-linked Kinase) that interacts with UNC-112 (Kindlin).
J Biol Chem Volume: 289 Page(s): 14252 - 14262
05/16/2014 Authors: Qadota H; Luo Y; Matsunaga Y; Park AS; Gernert KM; Benian GM
An approach for exploring interaction between two proteins in vivo.
Front Physiol Volume: 5 Page(s): 162
01/01/2014 Authors: Qadota H; Benian GM
Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family.
Biochem Soc Trans Volume: 41 Page(s): 1066 - 1071
08/01/2013 Authors: Mayans O; Benian GM; Simkovic F; Rigden DJ
ZYX-1, the unique zyxin protein of Caenorhabditis elegans, is involved in dystrophin-dependent muscle degeneration.
Mol Biol Cell Volume: 24 Page(s): 1232 - 1249
04/01/2013 Authors: Lecroisey C; Brouilly N; Qadota H; Mariol M-C; Rochette NC; Martin E; Benian GM; Sgalat L; Mounier N; Gieseler K
CPNA-1, a copine domain protein, is located at integrin adhesion sites and is required for myofilament stability in Caenorhabditis elegans.
Mol Biol Cell Volume: 24 Page(s): 601 - 616
03/01/2013 Authors: Warner A; Xiong G; Qadota H; Rogalski T; Vogl AW; Moerman DG; Benian GM
A family of indoles regulate virulence and Shiga toxin production in pathogenic E. coli.
PLoS One Volume: 8 Page(s): e54456
01/01/2013 Authors: Bommarius B; Anyanful A; Izrayelit Y; Bhatt S; Cartwright E; Wang W; Swimm AI; Benian GM; Schroeder FC; Kalman D
Insights into the function of the kindlin to ILK interaction from C. elegans
Volume: 24
01/01/2013 Authors: Qadota H; Gernert KM; Luo Y; Subramanian S; Conn GL; Benian GM
Interaction of UNC-89 (obscurin) with paramyosin in C-elegans muscle
MOLECULAR BIOLOGY OF THE CELL Volume: 24
01/01/2013 Authors: Qadota H; Kwon GE; Matsunaga Y; Heckman RS; Wilson KJ; Benian GM
Paradigm shifts in cardiovascular research from Caenorhabditis elegans muscle.
Trends Cardiovasc Med Volume: 22 Page(s): 201 - 209
11/01/2012 Authors: Epstein HF; Benian GM
Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase.
Proc Natl Acad Sci U S A Volume: 109 Page(s): 13608 - 13613
08/21/2012 Authors: von Castelmur E; Strmpfer J; Franke B; Bogomolovas J; Barbieri S; Qadota H; Konarev PV; Svergun DI; Labeit S; Benian GM
A molecular mechanism for the requirement of PAT-4 (integrin-linked kinase (ILK)) for the localization of UNC-112 (Kindlin) to integrin adhesion sites.
J Biol Chem Volume: 287 Page(s): 28537 - 28551
08/17/2012 Authors: Qadota H; Moerman DG; Benian GM
UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.
Mol Biol Cell Volume: 23 Page(s): 2623 - 2634
07/01/2012 Authors: Wilson KJ; Qadota H; Mains PE; Benian GM
Bending amplitude - a new quantitative assay of C. elegans locomotion: identification of phenotypes for mutants in genes encoding muscle focal adhesion components.
Methods Volume: 56 Page(s): 95 - 102
01/01/2012 Authors: Nahabedian JF; Qadota H; Stirman JN; Lu H; Benian GM
Introduction to methods in invertebrate muscle biology.
Methods Volume: 56 Page(s): 1 - 2
01/01/2012 Authors: Bernstein SI; Benian GM
Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.
PLoS One Volume: 7 Page(s): e40182
01/01/2012 Authors: Spooner PM; Bonner J; Maricq AV; Benian GM; Norman KR
Advances in Muscle Physiology and Pathophysiology 2011.
J Biomed Biotechnol Volume: 2012 Page(s): 930836
01/01/2012 Authors: Kontrogianni-Konstantopoulos A; Benian G; Granzier H
Immunofluorescent localization of proteins in Caenorhabditis elegans muscle.
Methods Mol Biol Volume: 798 Page(s): 171 - 181
01/01/2012 Authors: Wilson KJ; Qadota H; Benian GM
Caenorhabditis elegans muscle: a genetic and molecular model for protein interactions in the heart.
Circ Res Volume: 109 Page(s): 1082 - 1095
10/14/2011 Authors: Benian GM; Epstein HF
The Caenorhabditis elegans paxillin orthologue, PXL-1, is required for pharyngeal muscle contraction and for viability.
Mol Biol Cell Volume: 22 Page(s): 2551 - 2563
07/15/2011 Authors: Warner A; Qadota H; Benian GM; Vogl AW; Moerman DG
PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.
J Mol Biol Volume: 407 Page(s): 222 - 231
03/25/2011 Authors: Qadota H; Miyauchi T; Nahabedian JF; Stirman JN; Lu H; Amano M; Benian GM; Kaibuchi K
How to Catch Moby Dick: Systematic Identification of Binding Partners for UNC-89 (Obscurin)
Volume: 100 Page(s): 588 - 588
02/02/2011 Authors: Qadota H; Xiong G; Wilson K; Duran MB; Swartzbaugh E; Nahabedian J; Benian G
-actinin is required for the proper assembly of Z-disk/focal-adhesion-like structures and for efficient locomotion in Caenorhabditis elegans.
J Mol Biol Volume: 403 Page(s): 516 - 528
11/05/2010 Authors: Moulder GL; Cremona GH; Duerr J; Stirman JN; Fields SD; Martin W; Qadota H; Benian GM; Lu H; Barstead RJ
Extensive and modular intrinsically disordered segments in C. elegans TTN-1 and implications in filament binding, elasticity and oblique striation.
J Mol Biol Volume: 398 Page(s): 672 - 689
05/21/2010 Authors: Forbes JG; Flaherty DB; Ma K; Qadota H; Benian GM; Wang K
Molecular structure of sarcomere-to-membrane attachment at M-Lines in C. elegans muscle.
J Biomed Biotechnol Volume: 2010 Page(s): 864749
01/01/2010 Authors: Qadota H; Benian GM
Advances in muscle physiology and pathophysiology.
J Biomed Biotechnol Volume: 2010
01/01/2010 Authors: Kontrogianni-Konstantopoulos A; Benian G; Granzier H
CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle.
Mol Biol Cell Volume: 20 Page(s): 3608 - 3616
08/01/2009 Authors: Miller RK; Qadota H; Stark TJ; Mercer KB; Wortham TS; Anyanful A; Benian GM
Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity.
Cell Host Microbe Volume: 5 Page(s): 450 - 462
05/08/2009 Authors: Anyanful A; Easley KA; Benian GM; Kalman D
A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.
J Mol Biol Volume: 386 Page(s): 976 - 988
03/06/2009 Authors: Xiong G; Qadota H; Mercer KB; McGaha LA; Oberhauser AF; Benian GM
A C. elegans homolog of huntingtin-associated protein 1 is expressed in chemosensory neurons and in a number of other somatic cell types.
J Mol Neurosci Volume: 37 Page(s): 37 - 49
01/01/2009 Authors: Mercer KB; Szlam SM; Manning E; Gernert KM; Walthall WW; Benian GM; Gutekunst C-A
The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.
J Mol Biol Volume: 383 Page(s): 747 - 752
11/21/2008 Authors: Qadota H; Blangy A; Xiong G; Benian GM
Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.
Biophys J Volume: 95 Page(s): 1360 - 1370
08/01/2008 Authors: Greene DN; Garcia T; Sutton RB; Gernert KM; Benian GM; Oberhauser AF
A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.
Mol Biol Cell Volume: 19 Page(s): 2424 - 2432
06/01/2008 Authors: Qadota H; McGaha LA; Mercer KB; Stark TJ; Ferrara TM; Benian GM
UNC-98 and UNC-96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans.
Mol Biol Cell Volume: 19 Page(s): 1529 - 1539
04/01/2008 Authors: Miller RK; Qadota H; Mercer KB; Gernert KM; Benian GM
unc-94 encodes a tropomodulin in Caenorhabditis elegans.
J Mol Biol Volume: 374 Page(s): 936 - 950
12/07/2007 Authors: Stevenson TO; Mercer KB; Cox EA; Szewczyk NJ; Conley CA; Hardin JD; Benian GM
Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle.
Mol Biol Cell Volume: 18 Page(s): 4317 - 4326
11/01/2007 Authors: Qadota H; Mercer KB; Miller RK; Kaibuchi K; Benian GM
UNC-98 links an integrin-associated complex to thick filaments in Caenorhabditis elegans muscle.
J Cell Biol Volume: 175 Page(s): 853 - 859
12/18/2006 Authors: Miller RK; Qadota H; Landsverk ML; Mercer KB; Epstein HF; Benian GM
Caenorhabditis elegans UNC-96 is a new component of M-lines that interacts with UNC-98 and paramyosin and is required in adult muscle for assembly and/or maintenance of thick filaments.
Mol Biol Cell Volume: 17 Page(s): 3832 - 3847
09/01/2006 Authors: Mercer KB; Miller RK; Tinley TL; Sheth S; Qadota H; Benian GM
Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.
J Cell Sci Volume: 119 Page(s): 239 - 249
01/15/2006 Authors: Zastrow MS; Flaherty DB; Benian GM; Wilson KL
Paralysis and killing of Caenorhabditis elegans by enteropathogenic Escherichia coli requires the bacterial tryptophanase gene.
Mol Microbiol Volume: 57 Page(s): 988 - 1007
08/01/2005 Authors: Anyanful A; Dolan-Livengood JM; Lewis T; Sheth S; Dezalia MN; Sherman MA; Kalman LV; Benian GM; Kalman D
Titin/connectin-related proteins in C. elegans: a review and new findings.
J Muscle Res Cell Motil Volume: 26 Page(s): 435 - 447
01/01/2005 Authors: Ferrara TM; Flaherty DB; Benian GM
Nuclear titin interacts with A- and B-type lamins; Implications for nuclear architecture
Volume: 15 Page(s): 327A - 327A
11/01/2004 Authors: Zastrow MS; Flaherty DB; Benian GM; Wilson KL
UNC-98, a C-elegans muscle focal adhesion protein, unexpectedly interacts with a component of thick filaments
Volume: 15 Page(s): 275A - 275A
11/01/2004 Authors: Miller RK; Mercer KB; Flaherty DB; Benian GM
Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.
J Mol Biol Volume: 342 Page(s): 91 - 108
09/03/2004 Authors: Small TM; Gernert KM; Flaherty DB; Mercer KB; Borodovsky M; Benian GM
Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes.
Mol Biol Cell Volume: 14 Page(s): 2492 - 2507
06/01/2003 Authors: Mercer KB; Flaherty DB; Miller RK; Qadota H; Tinley TL; Moerman DG; Benian GM
Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes in Caenorhabditis elegans.
J Cell Sci Volume: 116 Page(s): 2073 - 2085
05/15/2003 Authors: Ono K; Parast M; Alberico C; Benian GM; Ono S
Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.
J Mol Biol Volume: 323 Page(s): 533 - 549
10/25/2002 Authors: Flaherty DB; Gernert KM; Shmeleva N; Tang X; Mercer KB; Borodovsky M; Benian GM
UNC-98 is a Zn finger protein required for proper assembly of dense bodies in C. elegans muscle
MOLECULAR BIOLOGY OF THE CELL Volume: 12 Page(s): 38A - 38A
11/01/2001 Authors: Mercer KB; Flaherty DB; Tinley TL; Tang XX; Boyte DP; Benian GM
A new isoform of UNC-89 with two MLCK-like protein kinase domains
MOLECULAR BIOLOGY OF THE CELL Volume: 12 Page(s): 37A - 37A
11/01/2001 Authors: Small TM; Flaherty DB; Mercer KB; Borodovsky M; Benian GM
Nematode titins: Giant polypeptides composed of multiple repeating motifs expressed in muscle, gut and neurons
MOLECULAR BIOLOGY OF THE CELL Volume: 12 Page(s): 39A - 39A
11/01/2001 Authors: Flaherty DB; Gernert KM; Mercer KB; Tang XX; Segalat L; Shmeleva N; Borodovsky M; Benian GM
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
J Cell Biol Volume: 154 Page(s): 879 - 891
08/20/2001 Authors: Edens WA; Sharling L; Cheng G; Shapira R; Kinkade JM; Lee T; Edens HA; Tang X; Sullards C; Flaherty DB
The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site.
J Biol Chem Volume: 276 Page(s): 5952 - 5958
02/23/2001 Authors: Ono S; McGough A; Pope BJ; Tolbert VT; Bui A; Pohl J; Benian GM; Gernert KM; Weeds AG
UNC-98, a gene implicated in intermediate filament protein organization in nematode muscle
MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 77A - 77A
12/01/2000 Authors: Flaherty DB; Tinley TL; Mercer K; Tang XX; Benian G
Muscular dystrophy: the worm turns to genetic disease.
Curr Biol Volume: 10 Page(s): R795 - R797
11/02/2000 Authors: Chamberlain JS; Benian GM
UNC-89 participates in Rho-like signaling to organize C-elegans muscle.
MOLECULAR BIOLOGY OF THE CELL Volume: 10 Page(s): 166A - 166A
11/01/1999 Authors: Tinley TL; Kindt R; Baraldi E; Kenyon C; Benian GM
UNC-60B, an ADF/cofilin family protein, is required for proper assembly of actin into myofibrils in Caenorhabditis elegans body wall muscle.
J Cell Biol Volume: 145 Page(s): 491 - 502
05/03/1999 Authors: Ono S; Baillie DL; Benian GM
The genetics and molecular biology of the titin/connectin-like proteins of invertebrates.
Rev Physiol Biochem Pharmacol Volume: 138 Page(s): 235 - 268
01/01/1999 Authors: Benian GM; Ayme-Southgate A; Tinley TL
Essential function of ADF/cofilin for actin assembly during myofibril formation in C-elegans.
MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 16A - 16A
11/01/1998 Authors: Ono S; Baillie DL; Benian GM
Unc-96: An intermediate filament protein of C-elegans muscle
MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 46A - 46A
11/01/1998 Authors: Tinley TL; Mercer KB; Alberico C; Tang X; Santoianni R; Benian GM
Two Caenorhabditis elegans actin depolymerizing factor/cofilin proteins, encoded by the unc-60 gene, differentially regulate actin filament dynamics.
J Biol Chem Volume: 273 Page(s): 3778 - 3783
02/06/1998 Authors: Ono S; Benian GM
Differential properties of two C-elegans ADF/cofilin proteins encoded by the UNC-60 gene.
MOLECULAR BIOLOGY OF THE CELL Volume: 8 Page(s): 898 - 898
11/01/1997 Authors: Ono S; Alberico C; Benian GM
Giant protein kinases: domain interactions and structural basis of autoregulation.
EMBO J Volume: 15 Page(s): 6810 - 6821
12/16/1996 Authors: Kobe B; Heierhorst J; Feil SC; Parker MW; Benian GM; Weiss KR; Kemp BE
Substrate specificity and inhibitor sensitivity of Ca2+/S100-dependent twitchin kinases.
Eur J Biochem Volume: 242 Page(s): 454 - 459
12/15/1996 Authors: Heierhorst J; Tang X; Lei J; Probst WC; Weiss KR; Kemp BE; Benian GM
Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.
J Mol Biol Volume: 264 Page(s): 624 - 639
12/06/1996 Authors: Fong S; Hamill SJ; Proctor M; Freund SM; Benian GM; Chothia C; Bycroft M; Clarke J
A search of UNC-89 interacting proteins by suppressor analysis
MOLECULAR BIOLOGY OF THE CELL Volume: 7 Page(s): 239 - 239
12/01/1996 Authors: Tinley T; Grimm H; Alberico C; Santoianni R; Benian G
A new twitchin is located in the intestinal brush border of C-elegans
MOLECULAR BIOLOGY OF THE CELL Volume: 7 Page(s): 1159 - 1159
12/01/1996 Authors: Tang X; Fleming J; Heierhorst J; Benian G
Rapid detection of mycobacteria in inflammatory necrotizing granulomas from formalin-fixed, paraffin-embedded tissue by PCR in clinically high-risk patients with acid-fast stain and culture-negative tissue biopsies.
Am J Clin Pathol Volume: 106 Page(s): 384 - 389
09/01/1996 Authors: Hardman WJ; Benian GM; Howard T; McGowan JE; Metchock B; Murtagh JJ
Ca2+/S100 regulation of giant protein kinases.
Nature Volume: 380 Page(s): 636 - 639
04/18/1996 Authors: Heierhorst J; Kobe B; Feil SC; Parker MW; Benian GM; Weiss KR; Kemp BE
The Caenorhabditis elegans gene unc-89, required fpr muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domains.
J Cell Biol Volume: 132 Page(s): 835 - 848
03/01/1996 Authors: Benian GM; Tinley TL; Tang X; Borodovsky M
ARCHITECTURE AND INTRASTERIC REGULATION OF GIANT PROTEIN KINASES
Volume: 52 Page(s): C185 - C186
01/01/1996 Authors: Kobe B; Heierhorst J; Feil SC; Parker MW; Benian GM; Kemp BE
Twitchin and related giant Ig superfamily members of C. elegans and other invertebrates.
Adv Biophys Volume: 33 Page(s): 183 - 198
01/01/1996 Authors: Benian GM; Tang X; Tinley TL
IDENTIFICATION OF A NEW TWITCHIN IN C-ELEGANS MUSCLE
MOLECULAR BIOLOGY OF THE CELL Volume: 6 Page(s): 854 - 854
11/01/1995 Authors: TANG X; WINGE P; HARDMAN W; FLEMING J; BENIAN G
EXTRAGENIC SUPPRESSORS OF UNC-89, THE PRODUCT OF A C-ELEGANS MUSCLE AFFECTING GENE
MOLECULAR BIOLOGY OF THE CELL Volume: 6 Page(s): 1455 - 1455
11/01/1995 Authors: TINLEY TL; GARGIULO C; LHERNAULT S; BENIAN GM
Both synchronous and asynchronous muscle isoforms of projectin (the Drosophila bent locus product) contain functional kinase domains.
J Cell Biol Volume: 128 Page(s): 393 - 403
02/01/1995 Authors: Ayme-Southgate A; Southgate R; Saide J; Benian GM; Pardue ML
Protein kinase domain of twitchin has protein kinase activity and an autoinhibitory region.
J Biol Chem Volume: 269 Page(s): 21078 - 21085
08/19/1994 Authors: Lei J; Tang X; Chambers TC; Pohl J; Benian GM
Insights into autoregulation from the crystal structure of twitchin kinase.
Nature Volume: 369 Page(s): 581 - 584
06/16/1994 Authors: Hu SH; Parker MW; Lei JY; Wilce MC; Benian GM; Kemp BE
Crystallization and preliminary X-ray analysis of the auto-inhibited twitchin kinase.
J Mol Biol Volume: 236 Page(s): 1259 - 1261
03/04/1994 Authors: Hu SH; Lei JY; Wilce MC; Valenzuela MR; Benian GM; Parker MW; Kemp BE
The use of deficiencies to determine essential gene content in the let-56-unc-22 region of Caenorhabditis elegans.
Genome Volume: 36 Page(s): 1148 - 1156
12/01/1993 Authors: Schein JE; Marra MA; Benian GM; Fields C; Baillie DL
Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegans.
Genetics Volume: 134 Page(s): 1097 - 1104
08/01/1993 Authors: Benian GM; L'Hernault SW; Morris ME
Genetic and molecular characterization of the Caenorhabditis elegans spermatogenesis-defective gene spe-17.
Genetics Volume: 134 Page(s): 769 - 780
07/01/1993 Authors: L'Hernault SW; Benian GM; Emmons RB
PROJECTIN, FLIGHTIN, AND MP20 - 3 NEW PROTEINS ASSOCIATED WITH THE CONTRACTILE APPARATUS
BIOPHYSICAL JOURNAL Volume: 64 Page(s): A1 - A1
02/01/1993 Authors: PARDUE ML; AYMESOUTHGATE A; VIGOREAUX J; SAIDE J; BENIAN G
STUDIES ON THE STRUCTURE AND ACTIVITY OF TWITCHIN AND A NEW MEMBER OF THE TWITCHIN TITIN FAMILY IN THE MUSCLE OF C-ELEGANS
MOLECULAR BIOLOGY OF THE CELL Volume: 3 Page(s): A46 - A46
09/01/1992 Authors: VALENZUELA MRL; LEI J; TANG X; DELAGARZA D; BENIAN GM
Drosophila has a twitchin/titin-related gene that appears to encode projectin.
Proc Natl Acad Sci U S A Volume: 88 Page(s): 7973 - 7977
09/15/1991 Authors: Ayme-Southgate A; Vigoreaux J; Benian G; Pardue ML
Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.
Nature Volume: 342 Page(s): 45 - 50
11/02/1989 Authors: Benian GM; Kiff JE; Neckelmann N; Moerman DG; Waterston RH
Transposable element Tc1 of Caenorhabditis elegans recognizes specific target sequences for integration.
Proc Natl Acad Sci U S A Volume: 85 Page(s): 861 - 864
02/01/1988 Authors: Mori I; Benian GM; Moerman DG; Waterston RH
Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans.
Genes Dev Volume: 2 Page(s): 93 - 105
01/01/1988 Authors: Moerman DG; Benian GM; Barstead RJ; Schriefer LA; Waterston RH
Practical modification of conventional blood culture systems for recovery of mycobacteria.
Diagn Microbiol Infect Dis Volume: 4 Page(s): 351 - 353
04/01/1986 Authors: Benian G; Murray P
Molecular cloning of the muscle gene unc-22 in Caenorhabditis elegans by Tc1 transposon tagging.
Proc Natl Acad Sci U S A Volume: 83 Page(s): 2579 - 2583
04/01/1986 Authors: Moerman DG; Benian GM; Waterston RH
Serum sickness following streptokinase therapy.
AJR Am J Roentgenol Volume: 138 Page(s): 143 - 144
01/01/1982 Authors: Totty WG; Romano T; Benian GM; Gilula LA; Sherman LA
Heterogeneity of concanavalin A receptors on Ehrlich tumor cells.
Prog Clin Biol Res Volume: 9 Page(s): 203 - 213
01/01/1976 Authors: Rittenhouse HG; Benian GM; Rittenhouse JW; Hansen ER; Boyd LE

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Guy Benian

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