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Profile

Oskar Laur MD, PhD

  • Department of Microbiology and Immunology
    Assistant Professor
  • (404) 727-8914
  • oliaur@emory.edu
  • Emory University School of Medicine
    Microbiology and Immunology
    Emory National Primate Research Center 2046
Head shot of Oskar Laur

Overview

Emory Custom Cloning Core Facility:
After completing his doctoral studies in molecular oncology, Dr. Oskar Laur has accumulated over twenty years of professional experience in multiple biomedical research fields, including neurophysiology, gene transcription, cell biology, immunology, vaccine development and protein structure and function studies. Dr. Laur is an expert in molecular cloning techniques and protein expression systems, and he has used his expertise to develop a rapid and economical DNA cloning process that is able to efficiently generate DNA constructs. In his three years as the director of the Emory Custom Cloning Core Facility (CCCF), he has used his unique molecular cloning process to produce over 1,500 constructs and has been acknowledged in twenty publications in top-tiered journals including Cell and Nature. The Emory CCCF is the only full-service cloning core facility in the United States, providing outstanding service to Emory clients at a fraction of the cost of commercial vendors. The Emory CCCF also provides valuable consultation services and has assisted clients in the design of constructs and experiments for gene expression and gene silencing in bacteria, viruses, cell lines and laboratory animals.

Research:
Development and optimization of methods for molecular cloning and protein expression
Structure and function of MHC class II and leukocyte adhesion molecules

Education

Degrees

  • PhD from Research Institute of Oncology
  • MD from St. Petersburg Medical Academy

Research

Focus

  • Structure/function studies of MHCII molecules Structure/function studies of adhesion molecules

Publications

  • Thermostable lamprey variable lymphocyte receptor antibody for detection of Plasmodium falciparum histidine rich protein-2.
    Sci Rep Volume: 15 Page(s): 17155
    05/17/2025 Authors: Tomar D; Singh B; Hirano M; Senanayake S; Aidoo M; Rogier E; Laur O; Herrin BR; Udhayakumar V
  • Production of Class II MHC Proteins in Lentiviral Vector-Transduced HEK-293T Cells for Tetramer Staining Reagents.
    Curr Protoc Volume: 1 Page(s): e36
    02/01/2021 Authors: Willis RA; Ramachandiran V; Shires JC; Bai G; Jeter K; Bell DL; Han L; Kazarian T; Ugwu KC; Laur O
  • LIN28B-PDZ BINDING KINASE SIGNALING PROMOTES NEUROBLASTOMA METASTASIS
    Volume: 67 Page(s): S148 - S149
    06/01/2020 Authors: Chen J; Cox J; Annam J; Weingart M; Essien G; Rathi K; Rokita JL; Khurana P; Cuya S; Pilgrim A
  • LIN28B promotes neuroblastoma metastasis and regulates PDZ binding kinase.
    Neoplasia Volume: 22 Page(s): 231 - 241
    04/24/2020 Authors: Chen D; Cox J; Annam J; Weingart M; Essien G; Rathi KS; Rokita JL; Khurana P; Cuya SM; Bosse KR
  • Yeast Short-Lived Actin-Associated Protein Forms a Metastable Prion in Response to Thermal Stress.
    Cell Rep Volume: 18 Page(s): 751 - 761
    01/17/2017 Authors: Chernova TA; Kiktev DA; Romanyuk AV; Shanks JR; Laur O; Ali M; Ghosh A; Kim D; Yang Z; Mang M
  • LAMPREY MONOCLONAL VLR ANTIBODIES AGAINST PLASMODIUM FALCIPARUM HISTIDINE RICH PROTEIN-2
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Volume: 97 Page(s): 93 - 94
    01/01/2017 Authors: Tomar D; Singh B; Rogier E; Hirano M; Laur O; Udhayakumar V; Herrin B; Cooper M
  • Short PQ interval on ECG in children: etiology of the phenomenon and its clinical significance
    Volume: 36 Page(s): 561 - 561
    08/01/2015 Authors: Oleichuk E; Kruchina T; Vinogradova I; Laur O; Novik G; Egorov D
  • Clinical course of paroxysmal atrioventricular nodal reentrant tachycardia in children
    Volume: 36 Page(s): 559 - 560
    08/01/2015 Authors: Kruchina T; Vinogradova I; Egorov D; Laur O; Novik G; Tatarsky B
  • Dexamethasone increases aquaporin-2 protein expression in ex vivo inner medullary collecting duct suspensions.
    Front Physiol Volume: 6 Page(s): 310
    01/01/2015 Authors: Chen M; Cai H; Klein JD; Laur O; Chen G
  • Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease.
    J Biol Chem Volume: 289 Page(s): 35296 - 35313
    12/19/2014 Authors: Diner I; Hales CM; Bishof I; Rabenold L; Duong DM; Yi H; Laur O; Gearing M; Troncoso J; Thambisetty M
  • Stress-dependent proteolytic processing of the actin assembly protein Lsb1 modulates a yeast prion.
    J Biol Chem Volume: 289 Page(s): 27625 - 27639
    10/03/2014 Authors: Ali M; Chernova TA; Newnam GP; Yin L; Shanks J; Karpova TS; Lee A; Laur O; Subramanian S; Kim D
  • IFN-induced suppression of -catenin signaling: evidence for roles of Akt and 14.3.3.
    Mol Biol Cell Volume: 25 Page(s): 2894 - 2904
    10/01/2014 Authors: Nava P; Kamekura R; Quirs M; Medina-Contreras O; Hamilton RW; Kolegraff KN; Koch S; Candelario A; Romo-Parra H; Laur O
  • Trans-dimerization of JAM-A regulates Rap2 and is mediated by a domain that is distinct from the cis-dimerization interface.
    Mol Biol Cell Volume: 25 Page(s): 1574 - 1585
    05/01/2014 Authors: Monteiro AC; Luissint A-C; Sumagin R; Lai C; Vielmuth F; Wolf MF; Laur O; Reiss K; Spindler V; Stehle T
  • Inhibition of beta-catenin transactivation by IFN gamma is regulated by Akt1 and 14.3.3z
    Volume: 28
    04/01/2014 Authors: Candelario A; Nava-Dominguez P; Kamekura R; Laur O; Parkos C; Nusrat A
  • Nuclear structures surrounding internal lamin invaginations.
    J Cell Biochem Volume: 115 Page(s): 476 - 487
    03/01/2014 Authors: Legartov S; Stixov L; Laur O; Kozubek S; Sehnalov P; Brtov E
  • Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells.
    Am J Physiol Renal Physiol Volume: 303 Page(s): F1325 - F1332
    11/01/2012 Authors: Su H; Carter CB; Laur O; Sands JM; Chen G
  • Surfactant protein D (Sp-D) binds to membrane-proximal domain (D3) of signal regulatory protein (SIRP), a site distant from binding domain of CD47, while also binding to analogous region on signal regulatory protein (SIRP).
    J Biol Chem Volume: 287 Page(s): 19386 - 19398
    06/01/2012 Authors: Fournier B; Andargachew R; Robin AZ; Laur O; Voelker DR; Lee WY; Weber D; Parkos CA
  • Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis and degradation in MDCK cells
    FASEB JOURNAL Volume: 26
    04/01/2012 Authors: Chen G; Su H; Carter CB; Froehlich O; Sands JM
  • CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation and colitogenic TH17 responses in mice
    FASEB JOURNAL Volume: 26
    04/01/2012 Authors: Medina-Contreras O; Geem D; Laur O; Williams IR; Lira SA; Nusrat A; Parkos CA; Denning TL
  • Use of replication restricted recombinant vesicular stomatitis virus vectors for detection of antigen-specific T cells.
    J Immunol Methods Volume: 375 Page(s): 118 - 128
    01/31/2012 Authors: Moseley NB; Laur O; Ibegbu CC; Loria GD; Ikwuenzunma G; Jayakar HR; Whitt MA; Altman JD
  • CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.
    J Clin Invest Volume: 121 Page(s): 4787 - 4795
    12/01/2011 Authors: Medina-Contreras O; Geem D; Laur O; Williams IR; Lira SA; Nusrat A; Parkos CA; Denning TL
  • Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling.
    Mol Cell Volume: 42 Page(s): 673 - 688
    06/10/2011 Authors: Muddashetty RS; Nalavadi VC; Gross C; Yao X; Xing L; Laur O; Warren ST; Bassell GJ
  • Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation.
    Mol Biol Cell Volume: 22 Page(s): 1677 - 1685
    05/15/2011 Authors: Capaldo CT; Koch S; Kwon M; Laur O; Parkos CA; Nusrat A
  • Ligand binding to SIRP alpha: evidence for carbohydrate-dependent binding of surfactant protein (Sp-D) to the D3 domain of SIRP alpha
    Volume: 25
    04/01/2011 Authors: Fournier B; Andargachew R; Robin AZ; Laur O; Voelker DR; Lee WY; Weber D; Parkos CA
  • Characterization of full-length and proteolytic cleavage fragments of desmoglein-2 in native human colon and colonic epithelial cell lines.
    Cell Adh Migr Volume: 5 Page(s): 306 - 314
    01/01/2011 Authors: Kolegraff K; Nava P; Laur O; Parkos CA; Nusrat A
  • The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47.
    J Biol Chem Volume: 285 Page(s): 37953 - 37963
    12/03/2010 Authors: Lee WY; Weber DA; Laur O; Stowell SR; McCall I; Andargachew R; Cummings RD; Parkos CA
  • A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.
    Mol Pain Volume: 6 Page(s): 33
    06/02/2010 Authors: Gris P; Gauthier J; Cheng P; Gibson DG; Gris D; Laur O; Pierson J; Wentworth S; Nackley AG; Maixner W
  • Regulation of SIRPa binding to CD47: Evidence for a role of Cis-homodimerization
    FASEB JOURNAL Volume: 23
    04/01/2009 Authors: Lee WY; Weber DA; Laur O; Parkos CA
  • Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes.
    J Infect Dis Volume: 198 Page(s): 500 - 507
    08/15/2008 Authors: Pulendran B; Miller J; Querec TD; Akondy R; Moseley N; Laur O; Glidewell J; Monson N; Zhu T; Zhu H
  • Novel structural determinants on SIRP alpha that mediate binding to CD47.
    J Immunol Volume: 179 Page(s): 7741 - 7750
    12/01/2007 Authors: Lee WY; Weber DA; Laur O; Severson EA; McCall I; Jen RP; Chin AC; Wu T; Gernert KM; Parkos CA
  • Desmoglein-2: a novel regulator of apoptosis in the intestinal epithelium.
    Mol Biol Cell Volume: 18 Page(s): 4565 - 4578
    11/01/2007 Authors: Nava P; Laukoetter MG; Hopkins AM; Laur O; Gerner-Smidt K; Green KJ; Parkos CA; Nusrat A
  • Stable and unstable cadherin dimers: mechanisms of formation and roles in cell adhesion.
    Mol Biol Cell Volume: 18 Page(s): 4343 - 4352
    11/01/2007 Authors: Troyanovsky RB; Laur O; Troyanovsky SM
  • Structural requirements of SIRP alpha binding to CD47
    Volume: 21 Page(s): A132 - A132
    04/01/2007 Authors: Lee WY; Weber D; Laur O; McCall I; Jen R; Gernert KM; Parkos C
  • Annexin 2 regulates intestinal epithelial cell spreading and wound closure through Rho-related signaling.
    Am J Pathol Volume: 170 Page(s): 951 - 966
    03/01/2007 Authors: Babbin BA; Parkos CA; Mandell KJ; Winfree LM; Laur O; Ivanov AI; Nusrat A
  • An MHC class Ib-restricted TCR that cross-reacts with an MHC class Ia molecule.
    J Immunol Volume: 174 Page(s): 7746 - 7752
    06/15/2005 Authors: Reed-Loisel LM; Sullivan BA; Laur O; Jensen PE
  • Analysis of the structural basis for DM function
    Volume: 19 Page(s): A1431 - A1431
    03/07/2005 Authors: Weber DA; Dao CT; Laur O; Jensen PE
  • A role for pocket 4 in HLA-DM function
    Volume: 18 Page(s): A35 - A36
    03/23/2004 Authors: Laur O; Weber D; Jensen PE
  • A Qa-1(b) restricted insulin specific T cell receptor with alloreactivity to H-2(q)
    Volume: 18 Page(s): A39 - A40
    03/23/2004 Authors: Reed-Loisel LM; Sullivan BA; Laur O; Jensen PE
  • The nonclassical MHC class I molecule Qa-1 forms unstable peptide complexes.
    J Immunol Volume: 172 Page(s): 1661 - 1669
    02/01/2004 Authors: Kambayashi T; Kraft-Leavy JR; Dauner JG; Sullivan BA; Laur O; Jensen PE
  • Exchange of catenins in cadherin-catenin complex.
    Oncogene Volume: 22 Page(s): 1181 - 1188
    02/27/2003 Authors: Klingelhfer J; Troyanovsky RB; Laur OY; Troyanovsky S
  • Exchange of catenins in cadherin-catenin complex
    Volume: 13 Page(s): 8A - 9A
    11/01/2002 Authors: Klingelhofer J; Troyanovsky RB; Laur O; Troyanovsky SM
  • Dynamic interplay between adhesive and lateral E-cadherin dimers.
    Mol Cell Biol Volume: 22 Page(s): 7449 - 7458
    11/01/2002 Authors: Klingelhfer J; Laur OY; Troyanovsky RB; Troyanovsky SM
  • Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development.
    J Exp Med Volume: 195 Page(s): 1053 - 1062
    04/15/2002 Authors: Chen X; Laur O; Kambayashi T; Li S; Bray RA; Weber DA; Karlsson L; Jensen PE
  • Both the dimerization and immunochemical properties of E-cadherin EC1 domain depend on Trp(156) residue.
    Arch Biochem Biophys Volume: 400 Page(s): 141 - 147
    04/01/2002 Authors: Laur OY; Klingelhfer J; Troyanovsky RB; Troyanovsky SM
  • Regulated HLA-DO expression during B cell development and the germinal center reaction
    FASEB JOURNAL Volume: 16 Page(s): A704 - A704
    03/20/2002 Authors: Chen XJ; Laur O; Kambayashi T; Li SY; Bray RA; Weber D; Kalsson L; Jensen PE
  • Adhesive E-cadherin dieters are a major and a highly dynamic form of dietetic E-cadherin complexes
    Volume: 12 Page(s): 348A - 348A
    11/01/2001 Authors: Klingelhofer J; Laur OY; Troyanovsky RB; Troyanovsky SM
  • Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions.
    J Cell Sci Volume: 113 ( Pt 16) Page(s): 2829 - 2836
    08/01/2000 Authors: Klingelhfer J; Troyanovsky RB; Laur OY; Troyanovsky S
  • T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB.
    Eur J Immunol Volume: 30 Page(s): 661 - 670
    02/01/2000 Authors: Li-Weber M; Laur O; Dern K; Krammer PH
  • Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation.
    Eur J Immunol Volume: 29 Page(s): 3017 - 3027
    09/01/1999 Authors: Li-Weber M; Laur O; Krammer PH
  • A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation.
    Eur J Immunol Volume: 28 Page(s): 2373 - 2383
    08/01/1998 Authors: Li-Weber M; Laur O; Hekele A; Coy J; Walczak H; Krammer PH
  • Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter.
    J Immunol Volume: 161 Page(s): 1380 - 1389
    08/01/1998 Authors: Li-Weber M; Salgame P; Hu C; Davydov IV; Laur O; Klevenz S; Krammer PH
  • What controls tissue-specific expression of the IL-4 gene?
    Immunobiology Volume: 198 Page(s): 170 - 178
    12/01/1997 Authors: Li-Weber M; Laur O; Davydov I; Hu C; Salgame P; Krammer PH
  • Amplification of ERBB-2 (HER-2/NEU), ERBB-1 (HER-1) and C-MYC oncogenes often combines with the deletion of chromosome 17 short arm in human carcinomas
    Volume: 33 Page(s): 46 - 46
    09/01/1997 Authors: Hanson KP; Imyanitov EN; Chernitsa OI; Nikiforova IF; Laur OY; Knyazev PG; Togo AV
  • EFFECT OF DESFERRIOXAMINE (DESFERAL) ON EPILEPTIC FOCUS FORMATION IN RATS AFTER SUBDURAL INJECTION OF BLOOD
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE Volume: 113 Page(s): 493 - 495
    04/01/1992 Authors: LAUR OY; GUSAKOV IV; IVANENKO AI
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