Publications

• Disease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy.
  Sci Transl Med Volume: 17 Page(s): eadt0527
  03/19/2025 Authors: Hoffman OR; Koehler JL; Espina JEC; Patterson AM; Gohar ES; Coleman EM; Schoenike BA; Espinosa-Garcia C; Paredes F; Varvel NH
• Disease modification upon brief exposure to tofacitinib during chronic epilepsy.
  bioRxiv
  11/21/2024 Authors: Hoffman OR; Koehler JL; Espina JEC; Patterson AM; Gohar ES; Coleman E; Schoenike BA; Espinosa-Garcia C; Paredes F; Varvel NH
• Takin' Out the Trash for Brain Health!
  Epilepsy Curr Volume: 24 Page(s): 292 - 294
  01/01/2024 Authors: Varvel NH
• Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus.
  Sci Rep Volume: 13 Page(s): 5651
  04/06/2023 Authors: Alemn-Ruiz C; Wang W; Dingledine R; Varvel NH
• Preclinical development of an EP2 antagonist for post-seizure cognitive deficits.
  Neuropharmacology Volume: 224 Page(s): 109356
  02/15/2023 Authors: Varvel NH; Amaradhi R; Espinosa-Garcia C; Duddy S; Franklin R; Banik A; Alemn-Ruiz C; Blackmer-Raynolds L; Wang W; Honore T
• Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system.
  Front Immunol Volume: 13 Page(s): 1056417
  01/01/2022 Authors: Houser MC; Uriarte Huarte O; Wallings RL; Keating CE; MacPherson KP; Herrick MK; Kannarkat GT; Kelly SD; Chang J; Varvel NH
• Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus.
  J Neurosci Volume: 41 Page(s): 1105 - 1117
  02/03/2021 Authors: Varvel NH; Espinosa-Garcia C; Hunter-Chang S; Chen D; Biegel A; Hsieh A; Blackmer-Raynolds L; Ganesh T; Dingledine R
• Loss of progranulin leads to dysregulation of innate and adaptive immune cell populations, increased susceptibility to experimental colitis, and brain infiltration of peripheral immune cells
  Alzheimer's & Dementia Volume: 16
  12/01/2020 Authors: Keating CE; Houser MC; MacPherson KP; Herrick MK; Coomes A; Joers VL; Oliver D; Johnson AG; Chang J; McEachin Z
• The COX-2/prostanoid signaling cascades in seizure disorders.
  Expert Opin Ther Targets Volume: 23 Page(s): 1 - 13
  01/01/2019 Authors: Rojas A; Chen D; Ganesh T; Varvel NH; Dingledine R
• 5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease.
  J Alzheimers Dis Volume: 70 Page(s): 1259 - 1274
  01/01/2019 Authors: Manji Z; Rojas A; Wang W; Dingledine R; Varvel NH; Ganesh T
• Functional Analysis of Brain-Engrafted Monocytes After Microglia Ablation in Mouse Models.
  Methods Mol Biol Volume: 2034 Page(s): 293 - 301
  01/01/2019 Authors: Varvel NH; Ransohoff RM; Neher JJ
• Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus.
  Proc Natl Acad Sci U S A Volume: 113 Page(s): E5665 - E5674
  09/20/2016 Authors: Varvel NH; Neher JJ; Bosch A; Wang W; Ransohoff RM; Miller RJ; Dingledine R
• Replacement of brain-resident myeloid cells does not alter cerebral amyloid- deposition in mouse models of Alzheimer's disease.
  J Exp Med Volume: 212 Page(s): 1803 - 1809
  10/19/2015 Authors: Varvel NH; Grathwohl SA; Degenhardt K; Resch C; Bosch A; Jucker M; Neher JJ
• Candidate drug targets for prevention or modification of epilepsy.
  Annu Rev Pharmacol Toxicol Volume: 55 Page(s): 229 - 247
  01/01/2015 Authors: Varvel NH; Jiang J; Dingledine R
• Microglial derived tumor necrosis factor- drives Alzheimer's disease-related neuronal cell cycle events.
  Neurobiol Dis Volume: 62 Page(s): 273 - 285
  02/01/2014 Authors: Bhaskar K; Maphis N; Xu G; Varvel NH; Kokiko-Cochran ON; Weick JP; Staugaitis SM; Cardona A; Ransohoff RM; Herrup K
• When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?
  Adv Exp Med Biol Volume: 813 Page(s): 109 - 122
  01/01/2014 Authors: Dingledine R; Varvel NH; Dudek FE
• When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?
  Advances in Experimental Medicine and Biology Volume: 813 Page(s): 109 - 122
  01/01/2014 Authors: Dingledine R; Varvel NH; Dudek FE
• When and How Do Seizures Kill Neurons, and Is Cell Death Relevant to Epileptogenesis?
  Advances in Experimental Medicine and Biology Page(s): 109 - 122
  01/01/2014 Authors: Dingledine R; Varvel NH; Dudek FE
• Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.
  Proc Natl Acad Sci U S A Volume: 109 Page(s): 18150 - 18155
  10/30/2012 Authors: Varvel NH; Grathwohl SA; Baumann F; Liebig C; Bosch A; Brawek B; Thal DR; Charo IF; Heppner FL; Aguzzi A
• Cell-autonomous effect of microglia on the induction of Alzheimer's disease neuronal cell cycle events
  Volume: 59 Page(s): 571 - 571
  09/01/2012 Authors: Bhaskar K; Maphis N; Varvel NH; Kokiko-Cochran ON; Ransohoff RM; Herrup K; Lamb BT
• The presence of A seeds, and not age per se, is critical to the initiation of A deposition in the brain.
  Acta Neuropathol Volume: 123 Page(s): 31 - 37
  01/01/2012 Authors: Hamaguchi T; Eisele YS; Varvel NH; Lamb BT; Walker LC; Jucker M
• Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease.
  Neurobiol Aging Volume: 33 Page(s): 197.e21 - 197.e32
  01/01/2012 Authors: Wilkinson BL; Cramer PE; Varvel NH; Reed-Geaghan E; Jiang Q; Szabo A; Herrup K; Lamb BT; Landreth GE
• CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
  Am J Pathol Volume: 177 Page(s): 2549 - 2562
  11/01/2010 Authors: Lee S; Varvel NH; Konerth ME; Xu G; Cardona AE; Ransohoff RM; Lamb BT
• Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2.
  Invest Ophthalmol Vis Sci Volume: 51 Page(s): 3264 - 3272
  06/01/2010 Authors: Edwards MM; Marn de Evsikova C; Collin GB; Gifford E; Wu J; Hicks WL; Whiting C; Varvel NH; Maphis N; Lamb BT
• NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.
  J Clin Invest Volume: 119 Page(s): 3692 - 3702
  12/01/2009 Authors: Varvel NH; Bhaskar K; Kounnas MZ; Wagner SL; Yang Y; Lamb BT; Herrup K
• The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
  J Neurosci Volume: 29 Page(s): 3565 - 3578
  03/18/2009 Authors: Muresan V; Varvel NH; Lamb BT; Muresan Z
• Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.
  J Neurosci Volume: 28 Page(s): 10786 - 10793
  10/22/2008 Authors: Varvel NH; Bhaskar K; Patil AR; Pimplikar SW; Herrup K; Lamb BT
• Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models.
  J Neurosci Volume: 26 Page(s): 775 - 784
  01/18/2006 Authors: Yang Y; Varvel NH; Lamb BT; Herrup K
• Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association.
  Mol Pharmacol Volume: 66 Page(s): 592 - 600
  09/01/2004 Authors: Moss MA; Varvel NH; Nichols MR; Reed DK; Rosenberry TL