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Profile

Nicholas Varvel

  • Department of Pharmacology & Chemical Biology
    Assistant Professor
  • nicholas.h.varvel@emory.edu
  • Emory University
    Pharmacology and Chemical Biology
    1510 Clifton Road, Suite 5002
Head shot of Nicholas Varvel

Overview

Research Area:
Innate immune cell responses in epilepsy.

Academic Appointment

  • Assistant Professor, Emory University School of Medicine

Education

Degrees

  • PhD from Case Western Reserve University
  • BS from University of Dayton

Research

Publications

  • Forged Without FIRE: Normal Brain Development in the Absence of Microglia.
    Epilepsy Curr Page(s): 15357597251348961
    06/16/2025 Authors: Varvel NH
  • CCR2 antagonism identifies blood-borne monocytes as a target for prevention of cognitive deficits after seizures.

    05/21/2025 Authors: Pourkhodadad S; Wang W; Dingledine R; Varvel NH
  • Disease modification upon 2 weeks of tofacitinib treatment in a mouse model of chronic epilepsy.
    Sci Transl Med Volume: 17 Page(s): eadt0527
    03/19/2025 Authors: Hoffman OR; Koehler JL; Espina JEC; Patterson AM; Gohar ES; Coleman EM; Schoenike BA; Espinosa-Garcia C; Paredes F; Varvel NH
  • Inflammation Emerges as a Sensitizer of a Heat-Responsive Cation Channel.
    Epilepsy Curr Volume: 25 Page(s): 184 - 186
    01/01/2025 Authors: Varvel NH
  • Disease modification upon brief exposure to tofacitinib during chronic epilepsy.
    bioRxiv
    11/21/2024 Authors: Hoffman OR; Koehler JL; Espina JEC; Patterson AM; Gohar ES; Coleman E; Schoenike BA; Espinosa-Garcia C; Paredes F; Varvel NH
  • Takin' Out the Trash for Brain Health!
    Epilepsy Curr Volume: 24 Page(s): 292 - 294
    01/01/2024 Authors: Varvel NH
  • Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus.
    Sci Rep Volume: 13 Page(s): 5651
    04/06/2023 Authors: Alemn-Ruiz C; Wang W; Dingledine R; Varvel NH
  • Preclinical development of an EP2 antagonist for post-seizure cognitive deficits.
    Neuropharmacology Volume: 224 Page(s): 109356
    02/15/2023 Authors: Varvel NH; Amaradhi R; Espinosa-Garcia C; Duddy S; Franklin R; Banik A; Alemn-Ruiz C; Blackmer-Raynolds L; Wang W; Honore T
  • Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system.
    Front Immunol Volume: 13 Page(s): 1056417
    01/01/2022 Authors: Houser MC; Uriarte Huarte O; Wallings RL; Keating CE; MacPherson KP; Herrick MK; Kannarkat GT; Kelly SD; Chang J; Varvel NH
  • Peripheral Myeloid Cell EP2 Activation Contributes to the Deleterious Consequences of Status Epilepticus.
    J Neurosci Volume: 41 Page(s): 1105 - 1117
    02/03/2021 Authors: Varvel NH; Espinosa-Garcia C; Hunter-Chang S; Chen D; Biegel A; Hsieh A; Blackmer-Raynolds L; Ganesh T; Dingledine R
  • The COX-2/prostanoid signaling cascades in seizure disorders.
    Expert Opin Ther Targets Volume: 23 Page(s): 1 - 13
    01/01/2019 Authors: Rojas A; Chen D; Ganesh T; Varvel NH; Dingledine R
  • 5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease.
    J Alzheimers Dis Volume: 70 Page(s): 1259 - 1274
    01/01/2019 Authors: Manji Z; Rojas A; Wang W; Dingledine R; Varvel NH; Ganesh T
  • Functional Analysis of Brain-Engrafted Monocytes After Microglia Ablation in Mouse Models.
    Methods Mol Biol Volume: 2034 Page(s): 293 - 301
    01/01/2019 Authors: Varvel NH; Ransohoff RM; Neher JJ
  • Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus.
    Proc Natl Acad Sci U S A Volume: 113 Page(s): E5665 - E5674
    09/20/2016 Authors: Varvel NH; Neher JJ; Bosch A; Wang W; Ransohoff RM; Miller RJ; Dingledine R
  • Replacement of brain-resident myeloid cells does not alter cerebral amyloid- deposition in mouse models of Alzheimer's disease.
    J Exp Med Volume: 212 Page(s): 1803 - 1809
    10/19/2015 Authors: Varvel NH; Grathwohl SA; Degenhardt K; Resch C; Bosch A; Jucker M; Neher JJ
  • Candidate drug targets for prevention or modification of epilepsy.
    Annu Rev Pharmacol Toxicol Volume: 55 Page(s): 229 - 247
    01/01/2015 Authors: Varvel NH; Jiang J; Dingledine R
  • Microglial derived tumor necrosis factor- drives Alzheimer's disease-related neuronal cell cycle events.
    Neurobiol Dis Volume: 62 Page(s): 273 - 285
    02/01/2014 Authors: Bhaskar K; Maphis N; Xu G; Varvel NH; Kokiko-Cochran ON; Weick JP; Staugaitis SM; Cardona A; Ransohoff RM; Herrup K
  • When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?
    Adv Exp Med Biol Volume: 813 Page(s): 109 - 122
    01/01/2014 Authors: Dingledine R; Varvel NH; Dudek FE
  • Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells.
    Proc Natl Acad Sci U S A Volume: 109 Page(s): 18150 - 18155
    10/30/2012 Authors: Varvel NH; Grathwohl SA; Baumann F; Liebig C; Bosch A; Brawek B; Thal DR; Charo IF; Heppner FL; Aguzzi A
  • Cell-autonomous effect of microglia on the induction of Alzheimer's disease neuronal cell cycle events
    Volume: 59 Page(s): 571 - 571
    09/01/2012 Authors: Bhaskar K; Maphis N; Varvel NH; Kokiko-Cochran ON; Ransohoff RM; Herrup K; Lamb BT
  • The presence of A seeds, and not age per se, is critical to the initiation of A deposition in the brain.
    Acta Neuropathol Volume: 123 Page(s): 31 - 37
    01/01/2012 Authors: Hamaguchi T; Eisele YS; Varvel NH; Lamb BT; Walker LC; Jucker M
  • Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease.
    Neurobiol Aging Volume: 33 Page(s): 197.e21 - 197.e32
    01/01/2012 Authors: Wilkinson BL; Cramer PE; Varvel NH; Reed-Geaghan E; Jiang Q; Szabo A; Herrup K; Lamb BT; Landreth GE
  • CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
    Am J Pathol Volume: 177 Page(s): 2549 - 2562
    11/01/2010 Authors: Lee S; Varvel NH; Konerth ME; Xu G; Cardona AE; Ransohoff RM; Lamb BT
  • Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2.
    Invest Ophthalmol Vis Sci Volume: 51 Page(s): 3264 - 3272
    06/01/2010 Authors: Edwards MM; Marn de Evsikova C; Collin GB; Gifford E; Wu J; Hicks WL; Whiting C; Varvel NH; Maphis N; Lamb BT
  • NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease.
    J Clin Invest Volume: 119 Page(s): 3692 - 3702
    12/01/2009 Authors: Varvel NH; Bhaskar K; Kounnas MZ; Wagner SL; Yang Y; Lamb BT; Herrup K
  • The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
    J Neurosci Volume: 29 Page(s): 3565 - 3578
    03/18/2009 Authors: Muresan V; Varvel NH; Lamb BT; Muresan Z
  • Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.
    J Neurosci Volume: 28 Page(s): 10786 - 10793
    10/22/2008 Authors: Varvel NH; Bhaskar K; Patil AR; Pimplikar SW; Herrup K; Lamb BT
  • Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models.
    J Neurosci Volume: 26 Page(s): 775 - 784
    01/18/2006 Authors: Yang Y; Varvel NH; Lamb BT; Herrup K
  • Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association.
    Mol Pharmacol Volume: 66 Page(s): 592 - 600
    09/01/2004 Authors: Moss MA; Varvel NH; Nichols MR; Reed DK; Rosenberry TL
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