Publications

• Pediatric Predictive Artificial Intelligence Implemented in Clinical Practice from 2010 to 2021: A Systematic Review.
  Appl Clin Inform Volume: 16 Page(s): 477 - 487
  05/01/2025 Authors: Kandaswamy S; Knake LA; Dziorny AC; Hernandez SM; McCoy AB; Hess LM; Orenstein E; White MS; Kirkendall ES; Molloy MJ
• Alert design in the real world: a cross-sectional analysis of interruptive alerting at 9 academic pediatric health systems.
  J Am Med Inform Assoc Volume: 32 Page(s): 682 - 688
  04/01/2025 Authors: Kandaswamy S; Yarahuan JKW; Dobler EA; Molloy MJ; Knake LA; Hernandez SM; Fallon AA; Hess LM; McCoy AB; Fortunov RM
• Development and Validation of an Artificial Intelligence Predictive Model to Accelerate Antibiotic Therapy for Critical Ill Children with Sepsis in the Pediatric ED with Pediatric ICU Disposition.
  medRxiv
  03/26/2025 Authors: Cao K; Braykov N; McCarter A; Kandaswamy S; Orenstein EW; Ray E; Carter R; Gleeson MB; Iyer S; Muthu N
• External Validation, Re-Calibration, and Extension of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children using Multi-Center Data.
  medRxiv
  02/06/2025 Authors: Dziorny AC; Drury S; Clark A; Farris RW; Nishisaki A; Cornell TT; Tawfik DS; Bennett TD; Shah SS; Weiss SL
• A Comprehensive Approach to Clinical Decision Support in the Return of Genome Informed Risk Assessments to Primary Care Pediatricians.
  Appl Clin Inform Volume: 16 Page(s): 193 - 204
  01/01/2025 Authors: Karavite D; Terek S; Connolly JJ; Harr M; Muthu N; Hakonarson H; Grundmeier RW
• Realizing the Full Potential of Clinical Decision Support: Translating Usability Testing into Routine Practice in Health Care Operations.
  Appl Clin Inform Volume: 15 Page(s): 1039 - 1048
  10/01/2024 Authors: Kandaswamy S; Williams H; Thompson SA; Dawson TE; Muthu N; Orenstein EW
• Clinical Decision Support Principles for Quality Improvement and Research.
  Hosp Pediatr Volume: 14 Page(s): e219 - e224
  04/01/2024 Authors: Molloy MJ; Muthu N; Orenstein EW; Shelov E; Luo BT
• Between-hospital variation in clinical decision support availability for common inpatient pediatric conditions: Results of a national Pediatric Research in Inpatient Settings (PRS) Network survey.
  J Hosp Med Volume: 18 Page(s): 617 - 621
  07/01/2023 Authors: Carr LH; Oluwalade B; Muthu N; Beus J; Bonafide CP
• Clinical decision support with a comprehensive in-EHR patient tracking system improves genetic testing follow up.
  J Am Med Inform Assoc Volume: 30 Page(s): 1274 - 1283
  06/20/2023 Authors: Campbell IM; Karavite DJ; Mcmanus ML; Cusick FC; Junod DC; Sheppard SE; Lourie EM; Shelov ED; Hakonarson H; Luberti AA
• Classification of Health Information Technology Safety Events in a Pediatric Tertiary Care Hospital.
  J Patient Saf Volume: 19 Page(s): 251 - 257
  06/01/2023 Authors: Khan A; Karavite DJ; Muthu N; Shelov E; Nawab U; Desai B; Luo B
• Opportunities to improve diagnosis in emergency transfers to the pediatric intensive care unit.
  J Hosp Med Volume: 18 Page(s): 509 - 518
  06/01/2023 Authors: Mehta SD; Congdon M; Phillips CA; Galligan M; Hanna CM; Muthu N; Ruiz J; Stinson H; Shaw K; Sutton RM
• Returning integrated genomic risk and clinical recommendations: The eMERGE study.
  Genet Med Volume: 25 Page(s): 100006
  04/01/2023 Authors: Linder JE; Allworth A; Bland HT; Caraballo PJ; Chisholm RL; Clayton EW; Crosslin DR; Dikilitas O; DiVietro A; Esplin ED
• Measuring Training Disruptions Using an Informatics Based Tool.
  Acad Pediatr Volume: 23 Page(s): 7 - 11
  01/01/2023 Authors: Mai MV; Muthu N; Carroll B; Costello A; West DC; Dziorny AC
• Clinician Perspectives on Specifications for Metrics to Inform Pediatric Alarm Management.
  Biomed Instrum Technol Volume: 57 Page(s): 18 - 25
  01/01/2023 Authors: Ruppel H; Pohl E; Rodriguez-Paras C; Froh E; Perry K; McNamara M; Muthu N; Ferro D; Rasooly I; Bonafide CP
• Sustainable deimplementation of continuous pulse oximetry monitoring in children hospitalized with bronchiolitis: study protocol for the Eliminating Monitor Overuse (EMO) type III effectiveness-deimplementation cluster-randomized trial.
  Implement Sci Volume: 17 Page(s): 72
  10/21/2022 Authors: Bonafide CP; Xiao R; Schondelmeyer AC; Pettit AR; Brady PW; Landrigan CP; Wolk CB; Cidav Z; Ruppel H; Muthu N
• Clinical Decision Support in the PICU: Implications for Design and Evaluation.
  Pediatr Crit Care Med Volume: 23 Page(s): e392 - e396
  08/01/2022 Authors: Dziorny AC; Heneghan JA; Bhat MA; Karavite DJ; Sanchez-Pinto LN; McArthur J; Muthu N; Pediatric Data Science and Analytics (PEDAL) Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
• Diagnostic Reasoning of Resident Physicians in the Age of Clinical Pathways.
  J Grad Med Educ Volume: 14 Page(s): 466 - 474
  08/01/2022 Authors: Congdon M; Clancy CB; Balmer DF; Anderson H; Muthu N; Bonafide CP; Rasooly IR
• Characteristics of Emergency Room and Hospital Encounters Resulting From Consumer Home Monitors.
  Hosp Pediatr Volume: 12 Page(s): e239 - e244
  07/01/2022 Authors: Craig S; Rasooly IR; Kern-Goldberger AS; Luo B; Mai MV; Beus JM; Faulkenberry JG; Brent C; Herchline D; Muthu N
• Using Data-Driven Machine Learning to Predict Unplanned ICU Transfers with Critical Deterioration from Electronic Health Records.
  Stud Health Technol Inform Volume: 290 Page(s): 660 - 664
  06/06/2022 Authors: Shi L; Muthu N; Shaeffer GP; Sun Y; Ruiz Herrera VM; Tsui FR
• Clinical Decision Support Stewardship: Best Practices and Techniques to Monitor and Improve Interruptive Alerts.
  Appl Clin Inform Volume: 13 Page(s): 560 - 568
  05/01/2022 Authors: Chaparro JD; Beus JM; Dziorny AC; Hagedorn PA; Hernandez S; Kandaswamy S; Kirkendall ES; McCoy AB; Muthu N; Orenstein EW
• Leveraging EHR Data to Evaluate the Association of Late Recognition of Deterioration With Outcomes.
  Hosp Pediatr Volume: 12 Page(s): 447 - 460
  05/01/2022 Authors: Mehta SD; Muthu N; Yehya N; Galligan M; Porter E; McGowan N; Papili K; Favatella D; Liu H; Griffis H
• GOAL-DIRECTED TASK ANALYSIS TO UNDERSTAND THE ASSESSMENT OF SHARED SITUATIONAL AWARENESS
  Volume: 50 Page(s): 648 - 648
  01/01/2022 Authors: Spear C; Parsons A; Muthu N; Wolfe H; Sutton R; Tegtmeyer K; Zackoff M; Dewan M
• Erratum.
  Med Decis Making Volume: 42 Page(s): NP1
  01/01/2022
• The Alarm Burden of Excess Continuous Pulse Oximetry Monitoring Among Patients With Bronchiolitis.
  J Hosp Med Volume: 16 Page(s): 727 - 729
  12/01/2021 Authors: Rasooly IR; Makeneni S; Khan AN; Luo B; Muthu N; Bonafide CP
• Alert burden in pediatric hospitals: a cross-sectional analysis of six academic pediatric health systems using novel metrics.
  J Am Med Inform Assoc Volume: 28 Page(s): 2654 - 2660
  11/25/2021 Authors: Orenstein EW; Kandaswamy S; Muthu N; Chaparro JD; Hagedorn PA; Dziorny AC; Moses A; Hernandez S; Khan A; Huth HB
• EHR-Integrated Monitor Data to Measure Pulse Oximetry Use in Bronchiolitis.
  Hosp Pediatr Volume: 11 Page(s): 1073 - 1082
  10/01/2021 Authors: Kern-Goldberger AS; Rasooly IR; Luo B; Craig S; Ferro DF; Ruppel H; Parthasarathy P; Sergay N; Solomon CM; Lucey KE
• Physiologic Monitor Alarm Burden and Nurses' Subjective Workload in a Children's Hospital.
  Hosp Pediatr Volume: 11 Page(s): 703 - 710
  07/01/2021 Authors: Rasooly IR; Kern-Goldberger AS; Xiao R; Ponnala S; Ruppel H; Luo B; Craig S; Khan A; McLoone M; Ferro D
• EHR-DEFINED EMERGENCY TRANSFER IS ASSOCIATED WITH MORTALITY IN HOSPITALIZED CHILDREN
  Volume: 49 Page(s): 245 - 245
  01/01/2021 Authors: Mehta S; Muthu N; Bonafide C; Galligan M; Favatella D; Papili K; Porter E; Liu H; Yehya N; Sutton R
• Catalyzing Pediatric Electronic Health Record Usability and Safety Improvements.
  Pediatrics Volume: 146
  12/01/2020 Authors: Muthu N; Ratwani RM
• Analysis: Protocol for a New Method to Measure Physiologic Monitor Alarm Responsiveness.
  Biomed Instrum Technol Volume: 54 Page(s): 389 - 396
  11/01/2020 Authors: Luo B; McLoone M; Rasooly IR; Craig S; Muthu N; Won J; Ruppel H; Bonafide CP
• Performance of a Clinical Decision Support Tool to Identify PICU Patients at High Risk for Clinical Deterioration.
  Pediatr Crit Care Med Volume: 21 Page(s): 129 - 135
  02/01/2020 Authors: Dewan M; Muthu N; Shelov E; Bonafide CP; Brady P; Davis D; Kirkendall ES; Niles D; Sutton RM; Traynor D
• A maximum likelihood approach to electronic health record phenotyping using positive and unlabeled patients.
  J Am Med Inform Assoc Volume: 27 Page(s): 119 - 126
  01/01/2020 Authors: Zhang L; Ding X; Ma Y; Muthu N; Ajmal I; Moore JH; Herman DS; Chen J
• Reducing Albuterol Use in Children With Bronchiolitis.
  Pediatrics Volume: 145
  01/01/2020 Authors: Dunn M; Muthu N; Burlingame CC; Gahman AM; McCloskey M; Tyler LM; Ware EP; Zorc JJ
• Towards a Maturity Model for Clinical Decision Support Operations.
  Appl Clin Inform Volume: 10 Page(s): 810 - 819
  10/01/2019 Authors: Orenstein EW; Muthu N; Weitkamp AO; Ferro DF; Zeidlhack MD; Slagle J; Shelov E; Tobias MC
• Formative Usability Testing Reduces Severe Blood Product Ordering Errors.
  Appl Clin Inform Volume: 10 Page(s): 981 - 990
  10/01/2019 Authors: Orenstein EW; Boudreaux J; Rollins M; Jones J; Bryant C; Karavite D; Muthu N; Hike J; Williams H; Kilgore T
• Hidden health IT hazards: a qualitative analysis of clinically meaningful documentation discrepancies at transfer out of the pediatric intensive care unit.
  JAMIA Open Volume: 2 Page(s): 392 - 398
  10/01/2019 Authors: Orenstein EW; Ferro DF; Bonafide CP; Landrigan CP; Gillespie S; Muthu N
• Parent eReferral to Tobacco Quitline: A Pragmatic Randomized Trial in Pediatric Primary Care.
  Am J Prev Med Volume: 57 Page(s): 32 - 40
  07/01/2019 Authors: Jenssen BP; Muthu N; Kelly MK; Baca H; Shults J; Grundmeier RW; Fiks AG
• Electronic Health Record Phenotyping with Internally Assessable Performance (PhIAP) using Anchor-Positive and Unlabeled Patients
  
  01/30/2019 Authors: Zhang L; Ding X; Ma Y; Muthu N; Ajmal I; Moore JH; Herman DS; Chen J
• Physicians in the Era of Automation: The Case for Clinical Expertise.
  MDM Policy Pract Volume: 4 Page(s): 2381468319868968
  01/01/2019 Authors: Chartash D; Sassoon D; Muthu N
• IMPROVING A SCREENING CHECKLIST TO PREDICT ICU PATIENT CLINICAL DETERIORATION
  Volume: 47
  01/01/2019 Authors: Dewan M; Kirkendall E; Brady P; Traynor D; Shelov E; Muthu N; Tegtmeyer K; Niles D; Bonafide C; Davis D
• Development and Evaluation of High-Value Pediatrics: A High-Value Care Pediatric Resident Curriculum.
  Hosp Pediatr Volume: 8 Page(s): 785 - 792
  12/01/2018 Authors: Dewan M; Herrmann LE; Tchou MJ; Parsons A; Muthu N; Tenney-Soeiro R; Fieldston E; Lindell RB; Dziorny A; Gosdin C
• Identifying Electronic Health Record Usability And Safety Challenges In Pediatric Settings.
  Health Aff (Millwood) Volume: 37 Page(s): 1752 - 1759
  11/01/2018 Authors: Ratwani RM; Savage E; Will A; Fong A; Karavite D; Muthu N; Rivera AJ; Gibson C; Asmonga D; Moscovitch B
• User Testing an Information Foraging Tool for Ambulatory Surgical Site Infection Surveillance.
  Appl Clin Inform Volume: 9 Page(s): 791 - 802
  10/01/2018 Authors: Karavite DJ; Miller MW; Ramos MJ; Rettig SL; Ross RK; Xiao R; Muthu N; Localio AR; Gerber JS; Coffin SE
• A Heuristic Evaluation to Assess Use of After Visit Summaries for Supporting Continuity of Care.
  Appl Clin Inform Volume: 9 Page(s): 714 - 724
  07/01/2018 Authors: Tremoulet P; Krishnan R; Karavite D; Muthu N; Regli SH; Will A; Michel J
• Design and Implementation of a Pediatric ICU Acuity Scoring Tool as Clinical Decision Support.
  Appl Clin Inform Volume: 9 Page(s): 576 - 587
  07/01/2018 Authors: Shelov E; Muthu N; Wolfe H; Traynor D; Craig N; Bonafide C; Nadkarni V; Davis D; Dewan M
• Find Your Hotspot: Identification of High Risk Patients in the Pediatric ICU
  Volume: 142
  05/01/2018 Authors: Dewan ML; Traynor D; Shelov E; Muthu N; Bonafide C; Nadkarni V; Davis D; Wolfe H
• Reducing Albuterol Use in Children with Bronchiolitis
  Volume: 141
  01/01/2018 Authors: Dunn M; Muthu N; Gahman A; Zorc J; Rose S; Kaur T; McCloskey M; Tyler L; Ware E; Burlingame C