Nassir Mokarram-Dorri
Overview
Dr. Nassir Mokarram has a broad background in bioengineering, materials science, nanotechnology, and immunoengineering. He has been a pioneer in the field of immunomodulatory biomaterials for neural tissue. A trained bioengineer and polymer scientist, Dr. Mokarram did his graduate training at Georgia Institute of Technology on neural tissue regeneration, and completed his fellowship at Stanford University in Biodesign Innovation. His current research is focused on modulating immune response for tissue repair and cancer therapy. He is particularly interested in application of lessons learned from CNS repair mechanism to manage notoriously difficult to treat brain tumors, such as Glioblastoma.
Before joining Emory University School of Medicine, Department of Biomedical Engineering had been his home base since 2015 when he was appointed as a research faculty at Georgia Tech, and more recently, as an Assistant Research Professor at Duke University. Besides academia, Dr. Mokarram is a passionate healthcare technology advocate; he has been involved with the development of new medical technologies in multiple biotech and medtech startups and corporate firms ranging from endovascular occlusion gel to suprachoroidal drug delivery systems. He is a recent recipient of Breakthrough Device designation by the Food and Drug Administration for his use of nanofiber-based tumor guidance system.
Other ongoing research includes novel devices to cross blood brain barrier (BBB), immunomodulation strategies to create unique, multi-domain treatments for glioblastoma as well as other unorthodox approaches such as application of bacterial carrier to deliver therapies to GBM tumors.
Academic Appointment
- Associate Professor, Neurosurgery, Emory University
Research
Publications
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Device-assisted strategies for drug delivery across the blood-brain barrier to treat glioblastoma.
Commun Mater Volume: 6 Page(s): 5
01/01/2025 Authors: Mokarram N; Case A; Hossainy NN; Lyon JG; MacDonald TJ; Bellamkonda R -
A neural tract-inspired conduit for facile, on-demand biopsy of glioblastoma.
Neurooncol Adv Volume: 6 Page(s): vdae064
01/01/2024 Authors: Betancur MI; Case A; Ilich E; Mehta N; Meehan S; Pogrebivsky S; Keir ST; Stevenson K; Brahma B; Gregory S -
Need Statements in Healthcare Innovation.
Ann Biomed Eng Volume: 49 Page(s): 1587 - 1592
07/01/2021 Authors: Mokarram N; Denend L; Lyon J; Rait D; Brinton T; Makower J; Yock P -
Enriching neural stem cell and anti-inflammatory glial phenotypes with electrical stimulation after traumatic brain injury in male rats.
J Neurosci Res Volume: 99 Page(s): 1864 - 1884
07/01/2021 Authors: Park E; Lyon JG; Alvarado-Velez M; Betancur MI; Mokarram N; Shin JH; Bellamkonda RV -
Electrotaxis of Glioblastoma and Medulloblastoma Spheroidal Aggregates.
Sci Rep Volume: 9 Page(s): 5309
03/29/2019 Authors: Lyon JG; Carroll SL; Mokarram N; Bellamkonda RV -
Immunoengineering nerve repair.
Proc Natl Acad Sci U S A Volume: 114 Page(s): E5077 - E5084
06/27/2017 Authors: Mokarram N; Dymanus K; Srinivasan A; Lyon JG; Tipton J; Chu J; English AW; Bellamkonda RV -
Engineering challenges for brain tumor immunotherapy.
Adv Drug Deliv Rev Volume: 114 Page(s): 19 - 32
05/15/2017 Authors: Lyon JG; Mokarram N; Saxena T; Carroll SL; Bellamkonda RV -
Bacterial Carriers for Glioblastoma Therapy.
Mol Ther Oncolytics Volume: 4 Page(s): 1 - 17
03/17/2017 Authors: Mehta N; Lyon JG; Patil K; Mokarram N; Kim C; Bellamkonda RV -
Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes.
Biomaterials Volume: 63 Page(s): 158 - 167
09/01/2015 Authors: Lee S; Valmikinathan CM; Byun J; Kim S; Lee G; Mokarram N; Pai SB; Um E; Bellamkonda RV; Yoon Y-S -
Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments.
J Neurotrauma Volume: 31 Page(s): 1354 - 1361
08/01/2014 Authors: Lemmon VP; Ferguson AR; Popovich PG; Xu X-M; Snow DM; Igarashi M; Beattie CE; Bixby JL; MIASCI Consortium