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Profile

Nieraj Jain

  • Department of Ophthalmology
    Associate Professor
  • nieraj.jain@emory.edu
Head shot of Nieraj Jain

Overview

Nieraj Jain, MD, joined Emory Eye Center in March 2015 in the Vitreoretinal Surgery and Diseases service.

Dr. Jain graduated from Cornell University College of Engineering with a degree in biological and environmental engineering. He received his medical degree from Duke University School of Medicine followed by an internship in internal medicine at the University of Rochester, then a residency in ophthalmology at Duke where he served as chief resident. He subsequently completed a fellowship in vitreoretinal surgery at the University of Michigan, as well as a fellowship in ophthalmic genetics at the Casey Eye Institute in Oregon where he was supported by a Career Development Award from the Foundation Fighting Blindness.

His research explores the use of advanced retinal imaging modalities to assess disease progression and outcomes from novel treatments such as retinal gene therapy. He is actively engaged in interdisciplinary collaborations to broaden the application of novel imaging technologies.
National Recognition

Dr. Jain is a member of the Alpha Omega Alpha medical honor society, the American Academy of Ophthalmology, the Association for Research in Vision and Ophthalmology and is a diplomate of the American Board of Ophthalmology. Dr. Jain was a Heed Foundation Fellow and a Howard Hughes Medical Institute Research Scholar. His discovery of pentosan polysulfate maculopathy garnered Best Paper honors at the American Academy of Ophthalmology Annual Meeting in 2018.
Areas of Clinical Interest

Macular diseases

Retinal detachment

Inherited retinal diseases (such as Stargardt dystrophy and
retinitis pigmentosa)

Academic Appointment

  • Associate Professor, Ophthalmology, Emory University

Education

Degrees

  • MD from Duke School of Medicine
  • BS from Cornell University, College of Engineering

Research

Publications

  • Reply to Comment on "Pentosan Polysulfate Maculopathy: Final Outcomes From a 4-Year Prospective Study of Disease Progression After Drug Cessation".
    Am J Ophthalmol Volume: 274 Page(s): 297 - 298
    06/01/2025 Authors: Hall BP; Shiromani S; Jung EH; Lyons RJ; Tribe J; Jain N
  • Pentosan Polysulfate Maculopathy: Final Outcomes from a 4-Year Prospective Study of Disease Progression after Drug Cessation.
    Am J Ophthalmol Volume: 271 Page(s): 371 - 380
    03/01/2025 Authors: Hall BP; Shiromani S; Jung EH; Lyons RJ; Tribe J; Jain N
  • Artificial intelligence chatbot performance in triage of ophthalmic conditions.
    Can J Ophthalmol Volume: 59 Page(s): e301 - e308
    08/01/2024 Authors: Lyons RJ; Arepalli SR; Fromal O; Choi JD; Jain N
  • TOWARD AN IMAGING-CENTRIC DEFINITION OF NONPARANEOPLASTIC AUTOIMMUNE RETINOPATHY.
    Retina Volume: 44 Page(s): 868 - 877
    05/01/2024 Authors: Xu LT; Zheng A; Shantha JG; Yeh S; Yan J; Hubbard GB; Patel PS; Waltuck J; O'Keefe G; Jain N
  • Functional Vision in Patients With Biallelic USH2A Variants.
    Am J Ophthalmol Volume: 260 Page(s): 200 - 211
    04/01/2024 Authors: Heon E; Melia M; Bocchino LE; Samarakoon L; Duncan JL; Ayala AR; Audo I; Bradley C; Cheetham JK; Dagnelie G
  • JIGSAW RETINOPATHY.
    Retina Volume: 44 Page(s): 545 - 549
    03/01/2024 Authors: Marchese A; Harrell M; Jampol LM; Jain N; O'Keefe GAD
  • Pentosan Polysulfate Sodium Causes Diminished Function and Subtle Morphological Changes in Retina and RPE of Mice.
    Invest Ophthalmol Vis Sci Volume: 65 Page(s): 28
    02/01/2024 Authors: Girardot PE; Zhang X; Zhang N; Donaldson KJ; Chrenek MA; Sellers JT; Feola AJ; Papania J; Nickerson JM; Jain N
  • Characteristics of Vitamin A Deficiency Retinopathy at a Tertiary Referral Center in the United States.
    Ophthalmol Retina Volume: 8 Page(s): 126 - 136
    02/01/2024 Authors: Levine DA; Mathew NE; Jung EH; Yan J; Newman NJ; Thulasi P; Yeh S; Ziegler TR; Wells J; Jain N
  • Pentosan Polysulfate Maculopathy With 13 Years of Follow-up Imaging.
    J Vitreoretin Dis Volume: 8 Page(s): 325 - 333
    01/01/2024 Authors: Pinto AM; Jain N; Gupta RR
  • CRYSTALLINE RETINOPATHY IN A 6-YEAR-OLD BOY WITH HISTORY OF HIGH-DOSE TAMOXIFEN USE.
    Retin Cases Brief Rep Volume: 17 Page(s): 751 - 753
    11/01/2023 Authors: Mathew NE; Kozak J; Jayasundera KT; Jain N; Prabhu SS
  • Colopathy Associated with Pentosan Polysulfate Use.
    medRxiv
    04/04/2023 Authors: Jung EH; Zheng W; Weiss RJ; Mathew NE; Meyer BI; Nizam A; Iskandar H; Jain N
  • Two-Year Outcomes After Variable Duration of Drug Cessation in Patients With Maculopathy Associated With Pentosan Polysulfate Use.
    JAMA Ophthalmol Volume: 141 Page(s): 260 - 266
    03/01/2023 Authors: Jung EH; Lindeke-Myers A; Jain N
  • Readability, Content, and Accountability Assessment of Online Health Information for Retinitis Pigmentosa & Retinitis Pigmentosa Treatment Options.
    Volume: 44 Page(s): 43 - 48
    02/01/2023 Authors: Partin S; Westfall E; Sanda G; Branham K; Muir K; Bellcross C; Jain N
  • POTENTIAL NEW-ONSET CLINICALLY DETECTABLE PENTOSAN POLYSULFATE MACULOPATHY YEARS AFTER DRUG CESSATION.
    Retin Cases Brief Rep Volume: 16 Page(s): 724 - 726
    11/01/2022 Authors: Barnett JM; Jain N
  • PROLIFERATIVE RETINOPATHY IN A 13-YEAR-OLD WITH ADAMS-OLIVER SYNDROME.
    Retin Cases Brief Rep Volume: 16 Page(s): 762 - 765
    11/01/2022 Authors: Meyer BI; Williams PJ; Hanif AM; Lenhart PD; Hubbard GB; Jain N
  • Telemedicine-based approach to caring for patients with inherited retinal diseases: patient satisfaction and diagnostic testing completion rates.
    Ophthalmic Genet Volume: 43 Page(s): 641 - 645
    10/01/2022 Authors: Rali A; Partin S; Maa A; Yan J; Jain N
  • Risk Factors for Retinal Detachment in Acute Retinal Necrosis.
    Ophthalmol Retina Volume: 6 Page(s): 478 - 483
    06/01/2022 Authors: Bavinger JC; Anthony CL; Lindeke-Myers AT; Lynch S; Xu LT; Barnett J; Levine D; Patel P; Shah R; Jain N
  • Expanded Clinical Spectrum of Pentosan Polysulfate Maculopathy: A Macula Society Collaborative Study.
    Ophthalmol Retina Volume: 6 Page(s): 219 - 227
    03/01/2022 Authors: Jain N; Liao A; Garg SJ; Patel SN; Wykoff CC; Yu HJ; London NJS; Khurana RN; Zacks DN; Macula Society Pentosan Polysulfate Maculopathy Study Group
  • Surgical Outcomes of Progressive Retinoschisis-Related Retinal Detachments: A 17-Year Survey From a Large Academic Center.
    Ophthalmic Surg Lasers Imaging Retina Volume: 53 Page(s): 132 - 138
    03/01/2022 Authors: Liao A; Barnett J; Rehman I; Hamm D; Cribbs BE; Hendrick AM; Jain N; Yeh S; Hubbard GB; Yan J
  • Clinical Correlation between Acute Exudative Polymorphous Paraneoplastic Vitelliform Maculopathy and Metastatic Melanoma Disease Activity: A 48-month Longitudinal Case Report.
    Ocul Immunol Inflamm Volume: 30 Page(s): 330 - 337
    02/17/2022 Authors: Mueller CM; Hojjatie SL; Lawson DH; Jain N; Robinson J; Khan MK; Yushak ML; A Datoo O'Keefe G
  • Pentosan polysulfate maculopathy versus age-related macular degeneration: comparative assessment with multimodal imaging.
    Can J Ophthalmol Volume: 57 Page(s): 16 - 22
    02/01/2022 Authors: Christiansen JS; Barnes AC; Berry DE; Jain N
  • Intravitreal Pharmacotherapies for Diabetic Macular Edema: A Report by the American Academy of Ophthalmology.
    Ophthalmology Volume: 129 Page(s): 88 - 99
    01/01/2022 Authors: Ehlers JP; Yeh S; Maguire MG; Smith JR; Mruthyunjaya P; Jain N; Kim LA; Weng CY; Flaxel CJ; Schoenberger SD
  • Pentosan polysulfate maculopathy.
    Surv Ophthalmol Volume: 67 Page(s): 83 - 96
    01/01/2022 Authors: Lindeke-Myers A; Hanif AM; Jain N
  • Outcomes of Infectious Endophthalmitis in Patients with Systemic Antibiotic Allergies to Penicillins, Cephalosporins, or Vancomycin.
    Ophthalmol Retina Volume: 5 Page(s): 901 - 909
    09/01/2021 Authors: Meyer BI; Berry DE; Cribbs BE; Hendrick A; Jain N; Hubbard GB; O'Keefe G; Patel PS; Shantha JG; Yan J
  • PENTOSAN POLYSULFATE AND VISION: Findings from an International Survey of Exposed Individuals.
    Retina Volume: 41 Page(s): 1562 - 1569
    07/01/2021 Authors: Uner OE; Shah MK; Jain N
  • Salt-and-Pepper Retinopathy in a Woman With Hearing Loss.
    JAMA Ophthalmol Volume: 139 Page(s): 668 - 669
    06/01/2021 Authors: Meyer BI; Jain N
  • Re: Pentosan Polysulfate Maculopathy: What Urologists Should Know in 2020.
    Urology Volume: 152 Page(s): 205 - 206
    06/01/2021 Authors: Jain N
  • Patient Perceptions of SARS-CoV-2 Exposure Risk and Association With Continuity of Ophthalmic Care.
    JAMA Ophthalmol Volume: 139 Page(s): 508 - 515
    05/01/2021 Authors: Lindeke-Myers A; Zhao PYC; Meyer BI; Liu EA; Levine DA; Bennett OM; Ji S; Newman-Casey PA; Rao RC; Jain N
  • Long-term Macular Effects of Pentosan Polysulfate Sodium Exposure Uncertain-Let's Not Jump to Conclusions-Reply.
    JAMA Ophthalmol Volume: 139 Page(s): 364 - 365
    03/01/2021 Authors: Shah R; Jain N
  • Pentosan Polysulfate Maculopathy versus Inherited Macular Dystrophies: Comparative Assessment with Multimodal Imaging.
    Ophthalmol Retina Volume: 4 Page(s): 1196 - 1201
    12/01/2020 Authors: Barnes AC; Hanif AM; Jain N
  • Visual Function in Pentosan Polysulfate Sodium Maculopathy.
    Invest Ophthalmol Vis Sci Volume: 61 Page(s): 33
    11/02/2020 Authors: Lyons RJ; Brower J; Jain N
  • Rubber Bullet Ocular Trauma.
    Ophthalmology Volume: 127 Page(s): 1190
    09/01/2020 Authors: Barnes AC; Hudson LE; Jain N
  • Disease Course in Patients With Pentosan Polysulfate Sodium-Associated Maculopathy After Drug Cessation.
    JAMA Ophthalmol Volume: 138 Page(s): 894 - 900
    08/01/2020 Authors: Shah R; Simonett JM; Lyons RJ; Rao RC; Pennesi ME; Jain N
  • Association of macular disease with long-term use of pentosan polysulfate sodium: findings from a US cohort.
    Br J Ophthalmol Volume: 104 Page(s): 1093 - 1097
    08/01/2020 Authors: Jain N; Li AL; Yu Y; VanderBeek BL
  • EFFECT OF LUBRICANTS ON CORNEAL THICKNESS AFTER VITRECTOMY.
    Retina Volume: 40 Page(s): 1616 - 1622
    08/01/2020 Authors: Siegel DT; Hubbard GB; Yan J; Cribbs B; Jain N; Yeh S; Bui D; Smith J; Barb S; Pearce W
  • Feasibility and Efficacy of Same-Day, In-Office Genetic Testing for Inherited Retinal Diseases.
    J Vitreoretin Dis Volume: 4 Page(s): 181 - 185
    06/01/2020 Authors: Wilgucki JD; Williams PJ; Westfall E; Jain N; Yan J
  • Dopamine metabolite levels in the vitreous of diabetic and non-diabetic humans.
    Exp Eye Res Volume: 195 Page(s): 108040
    06/01/2020 Authors: Hendrick A; Smith J; Stelton C; Barb S; Yan J; Cribbs B; Jain N; Yeh S; Hubbard GB; He L
  • Re: Ludwig etal.: Pentosan polysulfate sodium exposure and drug-induced maculopathy in commercially insured patients in the United States (Ophthalmology. 2020;127:535-543).
    Ophthalmology Volume: 127 Page(s): e35 - e36
    05/01/2020 Authors: VanderBeek BL; Jain N
  • Pentosan Polysulfate-Associated Macular Disease in Patients With Interstitial Cystitis.
    Obstet Gynecol Volume: 135 Page(s): 1091 - 1094
    05/01/2020 Authors: Lyons RJ; Ahmad S; Ansari S; Foote JE; Jain N
  • Retinal Pigment Abnormalities in a Woman With Diabetes.
    JAMA Ophthalmol Volume: 138 Page(s): 316 - 317
    03/01/2020 Authors: Lyons RJ; Jain N
  • Phenotypic Spectrum of Pentosan Polysulfate Sodium-Associated Maculopathy: A Multicenter Study.
    JAMA Ophthalmol Volume: 137 Page(s): 1275 - 1282
    11/01/2019 Authors: Hanif AM; Armenti ST; Taylor SC; Shah RA; Igelman AD; Jayasundera KT; Pennesi ME; Khurana RN; Foote JE; O'Keefe GA
  • Strength of Association between Pentosan Polysulfate and a Novel Maculopathy.
    Ophthalmology Volume: 126 Page(s): 1464 - 1466
    10/01/2019 Authors: Hanif AM; Shah R; Yan J; Varghese JS; Patel SA; Cribbs BE; O'Keefe G; Hendrick AM; Shantha JG; Hubbard GB
  • Rhegmatogenous Retinal Detachment in Children: Clinical Factors Predictive of Successful Surgical Repair.
    Ophthalmology Volume: 126 Page(s): 1263 - 1270
    09/01/2019 Authors: Smith JM; Ward LT; Townsend JH; Yan J; Hendrick AM; Cribbs BE; Yeh S; Jain N; Hubbard GB
  • Late-Stage Sorsby Fundus Dystrophy Manifesting Severe Vision Loss in the Absence of Choroidal Neovascularization.
    Ophthalmic Surg Lasers Imaging Retina Volume: 50 Page(s): e215 - e217
    08/01/2019 Authors: Hanif AM; Jain N
  • Reply.
    Ophthalmology Volume: 126 Page(s): e51 - e52
    07/01/2019 Authors: Pearce W; Chen R; Jain N
  • Early Onset Neovascular Inflammatory Vitreoretinopathy Due to a De Novo CAPN5 Mutation: Report of a Case.
    Ocul Immunol Inflamm Volume: 27 Page(s): 706 - 708
    01/01/2019 Authors: O'Keefe G; Hanif AM; Mahajan VB; Jain N
  • Pattern Dystrophy: An Imprecise Diagnosis in the Age of Precision Medicine.
    Int Ophthalmol Clin Volume: 59 Page(s): 173 - 194
    01/01/2019 Authors: Hanif AM; Yan J; Jain N
  • Vogt-Koyanagi-Harada Disease Associated with Hepatitis B Vaccination.
    Ocul Immunol Inflamm Volume: 27 Page(s): 524 - 527
    01/01/2019 Authors: Sood AB; O'Keefe G; Bui D; Jain N
  • Re: FDA BRUDAC 2018 Criteria for Interstitial Cystitis/Bladder Pain Syndrome Clinical Trials: Future Direction for Research: J. C. Nickel and R. Moldwin J Urol 2018;200:39-42.
    J Urol Volume: 200 Page(s): 1122 - 1123
    11/01/2018 Authors: Pearce WA; Hanif AM; Jain N
  • Pigmentary Maculopathy Associated with Chronic Exposure to Pentosan Polysulfate Sodium.
    Ophthalmology Volume: 125 Page(s): 1793 - 1802
    11/01/2018 Authors: Pearce WA; Chen R; Jain N
  • Is exon 8 the most critical or the only dispensable exon of the VCAN gene? Insights into VCAN variants and clinical spectrum of Wagner syndrome.
    Am J Med Genet A Volume: 176 Page(s): 1778 - 1783
    08/01/2018 Authors: Ankala A; Jain N; Hubbard B; Alexander JJ; Shankar SP
  • Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials.
    JAMA Ophthalmol Volume: 136 Page(s): 666 - 677
    06/01/2018 Authors: Holz FG; Sadda SR; Busbee B; Chew EY; Mitchell P; Tufail A; Brittain C; Ferrara D; Gray S; Honigberg L
  • Atypical Retinal Lamination Pattern Associated with Bilateral Chorioretinal Coloboma.
    Ophthalmol Retina Volume: 2 Page(s): 256 - 257
    03/01/2018 Authors: Williams PJ; Prinzi RA; Robinson J; Jain N
  • Pericentral hydroxychloroquine retinopathy in a Caucasian female.
    Am J Ophthalmol Case Rep Volume: 9 Page(s): 93 - 95
    03/01/2018 Authors: Anand N; Prinzi RA; Hoeferlin C; Yan J; Jain N
  • Circumscribed White Retinal Mass.
    Retina Volume: 37 Page(s): e116 - e117
    10/01/2017 Authors: Prinzi RA; Wells JR; Jain N
  • Choriocapillaris evaluation in choroideremia using optical coherence tomography angiography.
    Biomed Opt Express Volume: 8 Page(s): 48 - 56
    01/01/2017 Authors: Gao SS; Patel RC; Jain N; Zhang M; Weleber RG; Huang D; Pennesi ME; Jia Y
  • Diagnostic and Therapeutic Challenges.
    Retina Volume: 36 Page(s): 2033 - 2037
    10/01/2016 Authors: Lee JY; Agrawal R; Tan CS; Chin CF; Jain N
  • Characterization of Chorioretinopathy Associated with Mitochondrial Trifunctional Protein Disorders: Long-Term Follow-up of 21 Cases.
    Ophthalmology Volume: 123 Page(s): 2183 - 2195
    10/01/2016 Authors: Boese EA; Jain N; Jia Y; Schlechter CL; Harding CO; Gao SS; Patel RC; Huang D; Weleber RG; Gillingham MB
  • Optical Coherence Tomography Angiography in Choroideremia: Correlating Choriocapillaris Loss With Overlying Degeneration.
    JAMA Ophthalmol Volume: 134 Page(s): 697 - 702
    06/01/2016 Authors: Jain N; Jia Y; Gao SS; Zhang X; Weleber RG; Huang D; Pennesi ME
  • Genotype-phenotype correlation in retinopathy associated with mitochondrial trifunctional protein disorders: Long-term follow-up of 21 cases
    Volume: 56
    06/01/2015 Authors: Boese EA; Jain N; Jia Y; Schlechter C; Harding C; Huang D; Weleber RG; Gillingham M; Pennesi ME
  • Methodology for visualization of reduced choriocapillaris density using optical coherence tomography angiography
    Volume: 56
    06/01/2015 Authors: Gao SS; Jia Y; Jain N; Pennesi ME; Huang D
  • OCT angiography provides insights into choroideremia pathology
    Volume: 56
    06/01/2015 Authors: Jain N; Jia Y; Gao SS; Gale MJ; Huang D; Weleber RG; Pennesi ME
  • Bilateral exudative retinal detachment in a diabetic patient with severe peripheral retinal ischemia.
    JAMA Ophthalmol Volume: 133 Page(s): 107 - 109
    01/01/2015 Authors: Michelotti MM; Jain N; Johnson MW
  • Bilateral acute endophthalmitis associated with munchausen syndrome.
    Retin Cases Brief Rep Volume: 9 Page(s): 177 - 180
    01/01/2015 Authors: Rao P; Shah AR; Michelotti MM; Anderson B; Abbey AM; Jain N; Stec L; Lowe L; Johnson MW; Williams GA
  • Pathogenesis and treatment of maculopathy associated with cavitary optic disc anomalies.
    Am J Ophthalmol Volume: 158 Page(s): 423 - 435
    09/01/2014 Authors: Jain N; Johnson MW
  • Vitrectomy alone in the management of giant retinal tears.
    Ophthalmic Surg Lasers Imaging Retina Volume: 45 Page(s): 421 - 427
    01/01/2014 Authors: Jain N; Kozak JA; Niziol LM; Musch DC; Zacks DN
  • Fingolimod-associated macular edema: incidence, detection, and management.
    Neurology Volume: 78 Page(s): 672 - 680
    02/28/2012 Authors: Jain N; Bhatti MT
  • Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: thirty-six-month results.
    Ophthalmology Volume: 119 Page(s): 132 - 137
    01/01/2012 Authors: Jain N; Stinnett SS; Jaffe GJ
  • Unanticipated vision loss after pars plana vitrectomy.
    Surv Ophthalmol Volume: 57 Page(s): 91 - 104
    01/01/2012 Authors: Jain N; McCuen BW; Mruthyunjaya P
  • Quantitative comparison of drusen segmented on SD-OCT versus drusen delineated on color fundus photographs.
    Invest Ophthalmol Vis Sci Volume: 51 Page(s): 4875 - 4883
    10/01/2010 Authors: Jain N; Farsiu S; Khanifar AA; Bearelly S; Smith RT; Izatt JA; Toth CA
  • Phase studies of model biomembranes: macroscopic coexistence of Lalpha+Lbeta, with light-induced coexistence of Lalpha+Lo Phases.
    Biochim Biophys Acta Volume: 1768 Page(s): 2777 - 2786
    11/01/2007 Authors: Zhao J; Wu J; Shao H; Kong F; Jain N; Hunt G; Feigenson G
  • Activation of human G protein-coupled receptor signaling pathway targeted genes by hydroxyurea in erythroid progenitor cells.
    Volume: 102 Page(s): 156B - 157B
    11/16/2003 Authors: Cokic VP; Jain N; Schechter AN
  • Experimental comparison of a liquid-crystal point-diffraction interferometer (LCPDI) and a commercial phase-shifting interferometer and methods to improve LCPDI accuracy.
    Appl Opt Volume: 41 Page(s): 1353 - 1365
    03/01/2002 Authors: Guardalben MJ; Ning L; Jain N; Battaglia DJ; Marshall KL
  • Phase-shift error as a result of molecular alignment distortions in a liquid-crystal point-diffraction interferometer.
    Opt Lett Volume: 25 Page(s): 1171 - 1173
    08/15/2000 Authors: Guardalben MJ; Jain N
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