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Profile

Nina Guzzetta MD

  • SOMPI
    Professor
  • nguzzet@emory.edu
Head shot of Nina Guzzetta

Overview

Dr. Guzzettas clinical expertise is in the anesthetic care of children with congenital heart disease presenting for cardiac surgery, cardiac catheterization procedures and non-cardiac surgeries. She trains residents and fellows in how to provide anesthesia for these patients. She also conducts extensive clinical research in this area primarily focusing on effective anticoagulation for cardiopulmonary bypass and the management of bleeding after cardiopulmonary bypass. Dr. Guzzetta is on the Board of Directors of the Congenital Cardiac Anesthesia Society and currently serves as vice-president.

Academic Appointment

  • Associate Professor, Emory University School of Medicine

Education

Degrees

  • MD from Emory University School of Medicine
  • BS from Vanderbilt University

Research

Focus

  • My research primarily focuses on clinical investigations involving 1) the anticoagulation management of pediatric cardiac surgical patients undergoing cardiopulmonary bypass and 2) reducing bleeding in pediatric cardiac surgical patients after cardiopulmonary bypass.

Publications

  • Effect of In Vivo Administration of Fibrinogen Concentrate Versus Cryoprecipitate on Ex Vivo Clot Degradation in Neonates Undergoing Cardiac Surgery.
    Anesth Analg
    08/08/2024 Authors: Downey LA; Moiseiwitsch N; Nellenbach K; Xiang Y; Brown AC; Guzzetta NA
  • Influence of Fibrinogen Concentrate on Neonatal Clot Structure When Administered Ex Vivo After Cardiopulmonary Bypass.
    Anesth Analg Volume: 137 Page(s): 682 - 690
    09/01/2023 Authors: Moiseiwitsch N; Nellenbach KA; Downey LA; Boorman D; Brown AC; Guzzetta NA
  • In Vivo Effects of Fibrinogen Concentrate (FC) versus Cryoprecipitate on the Neonatal Fibrin Network Structure after Cardiopulmonary Bypass (CPB)
    Volume: 134 Page(s): 842 - 845
    05/01/2022 Authors: Downey LA; Moiseiwitsch N; Nellenbach K; Miller KA; DeSilva DA; Brown A; Guzzetta N
  • Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics.
    Blood Adv Volume: 5 Page(s): 5202 - 5214
    12/14/2021 Authors: Nellenbach K; Kyu A; Guzzetta N; Brown AC
  • Antibodies to human leukocyte antigens and their association with blood product exposures in pediatric patients undergoing cardiac transplantation.
    Paediatr Anaesth Volume: 31 Page(s): 1065 - 1073
    10/01/2021 Authors: Cruz-Beltran S; Lane A; Seth S; Miller K; Moore RH; Sullivan HC; Fasano RM; Guzzetta NA
  • A retrospective study of the off-label Use of Activated 4-Factor Prothrombin Complex Concentrate in Neonates after Cardiac Surgery
    Volume: 132 Page(s): 107 - 111
    05/01/2021 Authors: Miller KA; Guzzetta N; Downey LA
  • Differential Sialic Acid Content in Adult and Neonatal Fibrinogen Mediate Differences in Clot Polymerization
    Volume: 136
    11/05/2020 Authors: Nellenbach KA; Guzzetta NA; Brown AC
  • In Response.
    Anesth Analg Volume: 131 Page(s): e84 - e86
    08/01/2020 Authors: Downey LA; Guzzetta NA
  • Considerations for Pediatric Heart Programs During COVID-19: Recommendations From the Congenital Cardiac Anesthesia Society.
    Anesth Analg Volume: 131 Page(s): 403 - 409
    08/01/2020 Authors: Faraoni D; Caplan LA; DiNardo JA; Guzzetta NA; Miller-Hance WC; Latham G; Momeni M; Nicolson SC; Spaeth JP; Taylor K
  • Not just small adults: Considering the impact of developmental hemostasis on neonatal extracorporeal circulation.
    J Thromb Haemost Volume: 18 Page(s): 1509 - 1510
    06/01/2020 Authors: Guzzetta NA; Downey LA
  • A Problem of Too Much Heterogeneity.
    Anesth Analg Volume: 130 Page(s): 1591 - 1593
    06/01/2020 Authors: Downey LA; Guzzetta NA
  • Ex Vivo Effect of Fibrinogen Concentrate on the Fibrin Network Structure in Neonates after Cardiopulmonary Bypass
    Volume: 130 Page(s): 87 - 88
    05/01/2020 Authors: Downey LA; Nellenbach K; Guzzetta N; Brown A
  • IARS Late-Breaking Abstract Submission-4249
    Volume: 130 Page(s): 93 - 95
    05/01/2020 Authors: Downey LA; Nellenbach K; Miller KA; Brown A; Guzzetta N
  • FEIBA administration reduces blood transfusions in pediatric patients with refractory bleeding after cardiopulmonary bypass surgery
    Volume: 130 Page(s): 84 - 86
    05/01/2020 Authors: Downey LA; Godret-Miertschin L; Miller KA; Guzzetta N
  • Comparison of Neonatal and Adult Fibrin Clot Properties between Porcine and Human Plasma.
    Anesthesiology Volume: 132 Page(s): 1091 - 1101
    05/01/2020 Authors: Nellenbach KA; Nandi S; Kyu A; Sivadanam S; Guzzetta NA; Brown AC
  • Fibrinogen Concentrate as an Alternative to Cryoprecipitate in a Postcardiopulmonary Transfusion Algorithm in Infants Undergoing Cardiac Surgery: A Prospective Randomized Controlled Trial.
    Anesth Analg Volume: 130 Page(s): 740 - 751
    03/01/2020 Authors: Downey LA; Andrews J; Hedlin H; Kamra K; McKenzie ED; Hanley FL; Williams GD; Guzzetta NA
  • The Congenital Cardiac Anesthesia Society-Society of Thoracic Surgeons Cardiac Anesthesia Database Collaboration.
    World J Pediatr Congenit Heart Surg Volume: 11 Page(s): 14 - 21
    01/01/2020 Authors: Vener DF; Abbasi RK; Brown M; Greene N; Guzzetta NA; Jacobs JP; Latham G; Mossad E; Nicolson SC; Twite M
  • Fellowship Training in Pediatric Cardiac Anesthesia: History, Maturation, and Current Status.
    J Cardiothorac Vasc Anesth Volume: 33 Page(s): 1828 - 1834
    07/01/2019 Authors: Nasr VG; Guzzetta NA; Mossad EB
  • News from the congenital cardiac anesthesia society.
    Paediatr Anaesth Volume: 29 Page(s): 397 - 398
    05/01/2019 Authors: Guzzetta NA
  • Preoperative Laboratory Studies for Pediatric Cardiac Surgery Patients: A Multi-Institutional Perspective.
    Anesth Analg Volume: 128 Page(s): 1051 - 1054
    05/01/2019 Authors: Jones SE; Jooste EH; Gottlieb EA; Schwartz J; Goswami D; Gautam NK; Benkwitz C; Downey LA; Guzzetta NA; Zabala L
  • Analysis of the structural and mechanical effects of procoagulant agents on neonatal fibrin networks following cardiopulmonary bypass.
    J Thromb Haemost Volume: 16 Page(s): 2159 - 2167
    11/01/2018 Authors: Nellenbach K; Guzzetta NA; Brown AC
  • Thromboelastography Is Associated With Surrogates for Bleeding After Pediatric Cardiac Operations.
    Volume: 106 Page(s): 799 - 806
    09/01/2018 Authors: Emani S; Sleeper LA; Faraoni D; Mulone M; Diallo F; DiNardo JA; Ibla J; Emani SM
  • Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.
    Pediatr Crit Care Med Volume: 19 Page(s): 884 - 898
    09/01/2018 Authors: Valentine SL; Bembea MM; Muszynski JA; Cholette JM; Doctor A; Spinella PC; Steiner ME; Tucci M; Hassan NE; Parker RI
  • Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.
    Pediatr Crit Care Med Volume: 19 Page(s): S121 - S126
    09/01/2018 Authors: Muszynski JA; Guzzetta NA; Hall MW; Macrae D; Valentine SL; Bateman ST; Spinella PC; Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI); Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network
  • Feasibility of autologous intraoperative blood collection and retransfusion in small children with complex congenital heart defects undergoing cardiopulmonary bypass.
    Paediatr Anaesth Volume: 28 Page(s): 795 - 802
    09/01/2018 Authors: Kaiser A; Miller K; Tian G; Moore RH; Guzzetta NA
  • Invited Commentary.
    Ann Thorac Surg Volume: 106 Page(s): 806
    09/01/2018 Authors: Guzzetta NA
  • Interpretation of Do Not Attempt Resuscitation Orders for Children Requiring Anesthesia and Surgery.
    Pediatrics Volume: 141
    05/01/2018 Authors: Fallat ME; Hardy C; SECTION ON SURGERY; SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE; COMMITTEE ON BIOETHICS
  • Consensus Statement by the Congenital Cardiac Anesthesia Society: Milestones for the Pediatric Cardiac Anesthesia Fellowship.
    Anesth Analg Volume: 126 Page(s): 198 - 207
    01/01/2018 Authors: Nasr VG; Guzzetta NA; Miller-Hance WC; Twite M; Latham GJ; Zabala L; Nicolson SC; Mossad EB; DiNardo JA
  • Evaluation of Novel Therapeutics To Treat Neonatal Coagulopathy
    Volume: 23 Page(s): S62 - S63
    12/01/2017 Authors: Nellenbach KA; Guzzetta N; Brown AC
  • The Congenital Cardiac Anesthesia Society: An Update on the First Twelve Years.
    J Cardiothorac Vasc Anesth Volume: 31 Page(s): 1939 - 1942
    12/01/2017 Authors: Guzzetta NA; Zabala L; Mossad EB
  • Thrombosis in Neonates and Infants After Cardiac Surgery-Another Piece of the Puzzle.
    J Cardiothorac Vasc Anesth Volume: 31 Page(s): 1949 - 1951
    12/01/2017 Authors: Guzzetta NA
  • Current use of factor concentrates in pediatric cardiac anesthesia.
    Paediatr Anaesth Volume: 27 Page(s): 678 - 687
    07/01/2017 Authors: Guzzetta NA; Williams GD
  • Clinical and Practical Aspects of Restoring Thrombin Generation in Acute Coagulopathic Bleeding.
    Anesth Analg Volume: 124 Page(s): 701
    02/01/2017 Authors: Tanaka KA; Bolliger D; Guzzetta NA
  • Fibrin Network Changes in Neonates after Cardiopulmonary Bypass (vol 124, pg 1021, 2016)
    ANESTHESIOLOGY Volume: 125 Page(s): 610 - 610
    09/01/2016 Authors: Brown AC; Hannan RH; Timmins LH; Fernandez JD; Barker TH; Guzzetta NA
  • Longitudinal Echocardiographic Evaluation of an Unusual Presentation of X-Linked Myxomatous Valvular Dystrophy Caused by Filamin A Mutation.
    Semin Cardiothorac Vasc Anesth Volume: 20 Page(s): 240 - 245
    09/01/2016 Authors: Ma PH; Sachdeva R; Wilson EC; Guzzetta NA
  • Computational simulation and comparison of prothrombin complex concentrate dosing schemes for warfarin reversal in cardiac surgery.
    J Anesth Volume: 30 Page(s): 369 - 376
    06/01/2016 Authors: Tanaka KA; Mazzeffi MA; Strauss ER; Szlam F; Guzzetta NA
  • Fibrin Network Changes in Neonates after Cardiopulmonary Bypass.
    Anesthesiology Volume: 124 Page(s): 1021 - 1031
    05/01/2016 Authors: Brown AC; Hannan RT; Timmins LH; Fernandez JD; Barker TH; Guzzetta NA
  • Optimizing Thrombin Generation with 4-Factor Prothrombin Complex Concentrates in Neonatal Plasma After Cardiopulmonary Bypass.
    Anesth Analg Volume: 122 Page(s): 935 - 942
    04/01/2016 Authors: Franklin SW; Szlam F; Fernandez JD; Leong T; Tanaka KA; Guzzetta NA
  • Cyanotic congenital heart disease (CCHD): focus on hypoxemia, secondary erythrocytosis, and coagulation alterations.
    Paediatr Anaesth Volume: 25 Page(s): 981 - 989
    10/01/2015 Authors: Zabala LM; Guzzetta NA
  • Excessive postoperative bleeding and outcomes in neonates undergoing cardiopulmonary bypass.
    Anesth Analg Volume: 120 Page(s): 405 - 410
    02/01/2015 Authors: Guzzetta NA; Allen NN; Wilson EC; Foster GS; Ehrlich AC; Miller BE
  • EARLY CELL SAVER TRANSFUSION DECREASES THE NEED FOR ALLOGENEIC BLOOD AFTER PEDIATRIC CARDIAC SURGERY
    CRITICAL CARE MEDICINE Volume: 42
    12/01/2014 Authors: Wolf M; Guzzetta N; Miller B; McGoldrick AM; Spitzer K
  • Ultrasoft microgels displaying emergent platelet-like behaviours.
    Nat Mater Volume: 13 Page(s): 1108 - 1114
    12/01/2014 Authors: Brown AC; Stabenfeldt SE; Ahn B; Hannan RT; Dhada KS; Herman ES; Stefanelli V; Guzzetta N; Alexeev A; Lam WA
  • Early postoperative bleeding is independently associated with increased surgical mortality in infants after cardiopulmonary bypass.
    J Thorac Cardiovasc Surg Volume: 148 Page(s): 631 - 6.e1
    08/01/2014 Authors: Wolf MJ; Maher KO; Kanter KR; Kogon BE; Guzzetta NA; Mahle WT
  • Augmentation of thrombin generation in neonates undergoing cardiopulmonary bypass.
    Br J Anaesth Volume: 112 Page(s): 319 - 327
    02/01/2014 Authors: Guzzetta NA; Szlam F; Kiser AS; Fernandez JD; Szlam AD; Leong T; Tanaka KA
  • A Study of Blood Utilization in Pediatric Cardiac Surgery
    Volume: 53 Page(s): 33A - 33A
    09/01/2013 Authors: Meyer E; Josephson C; Pahz S; Jessup P; Guzzetta N
  • In-hospital shunt occlusion in infants undergoing a modified blalock-taussig shunt.
    Ann Thorac Surg Volume: 96 Page(s): 176 - 182
    07/01/2013 Authors: Guzzetta NA; Foster GS; Mruthinti N; Kilgore PD; Miller BE; Kanter KR
  • Development and implementation of a new data registry in congenital cardiac anesthesia.
    Ann Thorac Surg Volume: 94 Page(s): 2159 - 2165
    12/01/2012 Authors: Vener DF; Guzzetta N; Jacobs JP; Williams GD
  • Change in heparin potency and effects on the activated clotting time in children undergoing cardiopulmonary bypass.
    Anesth Analg Volume: 115 Page(s): 921 - 924
    10/01/2012 Authors: Guzzetta NA; Amin SJ; Tosone AK; Miller BE
  • Review of the off-label use of recombinant activated factor VII in pediatric cardiac surgery patients.
    Anesth Analg Volume: 115 Page(s): 364 - 378
    08/01/2012 Authors: Guzzetta NA; Russell IA; Williams GD
  • Benefits and risks of red blood cell transfusion in pediatric patients undergoing cardiac surgery.
    Paediatr Anaesth Volume: 21 Page(s): 504 - 511
    05/01/2011 Authors: Guzzetta NA
  • Principles of hemostasis in children: models and maturation.
    Paediatr Anaesth Volume: 21 Page(s): 3 - 9
    01/01/2011 Authors: Guzzetta NA; Miller BE
  • Correlations between activated clotting time values and heparin concentration measurements in young infants undergoing cardiopulmonary bypass.
    Anesth Analg Volume: 111 Page(s): 173 - 179
    07/01/2010 Authors: Guzzetta NA; Monitz HG; Fernandez JD; Fazlollah TM; Knezevic A; Miller BE
  • Cor triatriatum dexter: a rare cause of neonatal cyanosis.
    Anesth Analg Volume: 110 Page(s): 716 - 718
    03/01/2010 Authors: Hoye DJ; Wilson EC; Fyfe DA; Guzzetta NA
  • Use of recombinant factor VIIa for uncontrolled bleeding in neonates after cardiopulmonary bypass.
    Paediatr Anaesth Volume: 19 Page(s): 364 - 370
    04/01/2009 Authors: Guzzetta NA; Huch S; Fernandez JD; Tosone SR; Miller BE
  • The impact of aprotinin on postoperative renal dysfunction in neonates undergoing cardiopulmonary bypass: a retrospective analysis.
    Anesth Analg Volume: 108 Page(s): 448 - 455
    02/01/2009 Authors: Guzzetta NA; Evans FM; Rosenberg ES; Fazlollah TM; Baker MJ; Wilson EC; Kaiser AM; Tosone SR; Miller BE
  • A comparison of heparin management strategies in infants undergoing cardiopulmonary bypass.
    Anesth Analg Volume: 106 Page(s): 419 - 425
    02/01/2008 Authors: Guzzetta NA; Bajaj T; Fazlollah T; Szlam F; Wilson E; Kaiser A; Tosone SR; Miller BE
  • Phenoxybenzamine in the treatment of hypoplastic left heart syndrome: a core review.
    Anesth Analg Volume: 105 Page(s): 312 - 315
    08/01/2007 Authors: Guzzetta NA
  • Clinical measures of heparin's effect and thrombin inhibitor levels in pediatric patients with congenital heart disease.
    Anesth Analg Volume: 103 Page(s): 1131 - 1138
    11/01/2006 Authors: Guzzetta NA; Miller BE; Todd K; Szlam F; Moore RH; Brosius KK; Wilson EC; Cohen AM; Tosone SR
  • An evaluation of the effects of a standard heparin dose on thrombin inhibition during cardiopulmonary bypass in neonates.
    Anesth Analg Volume: 100 Page(s): 1276 - 1282
    05/01/2005 Authors: Guzzetta NA; Miller BE; Todd K; Szlam F; Moore RH; Tosone SR
  • Fibrinogen in children undergoing cardiac surgery: is it effective?
    Anesth Analg Volume: 99 Page(s): 1341 - 1346
    11/01/2004 Authors: Miller BE; Tosone SR; Guzzetta NA; Miller JL; Brosius KK
  • Thrombin generation during cardiopulmonary bypass in neonates: Are we suppressing it?
    Volume: 98 Page(s): 9 - 9
    04/01/2004 Authors: Guzzetta N; Miller B; Tosone S
  • Tissue factor-activated thromboelastograms in children undergoing cardiac surgery: baseline values and comparisons.
    Anesth Analg Volume: 97 Page(s): 1289 - 1293
    11/01/2003 Authors: Miller BE; Guzzetta NA; Tosone SR; Miller JL; Flunker AR; Silvey EM; Levy JH
  • Rapid evaluation of coagulopathies after cardiopulmonary bypass in children using modified thromboelastography.
    Anesth Analg Volume: 90 Page(s): 1324 - 1330
    06/01/2000 Authors: Miller BE; Guzzetta NA; Tosone SR; Levy JH
  • Hematologic and economic impact of aprotinin in reoperative pediatric cardiac operations.
    Ann Thorac Surg Volume: 66 Page(s): 535 - 540
    08/01/1998 Authors: Miller BE; Tosone SR; Tam VK; Kanter KR; Guzzetta NA; Bailey JM; Levy JH
  • Clinical evaluation of the esophageal Doppler monitor for continuous cardiac output monitoring
    ANESTHESIA AND ANALGESIA Volume: 86 Page(s): SCA82 - SCA82
    04/01/1998 Authors: Guzzetta NA; Ramsay JG; Bailey JM; Palmer-Steele C
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