Nael McCarty PhD
Academic Appointment
- Marcus Professor of Cystic Fibrosis, Department of Pediatrics, PACS Division, Emory University School of Medicine
- Associate Chief for Research, Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis, and Sleep, Emory University School of Medicine
- Adjunct Assoc. Prof. of Biology, Georgia Inst. of Tech
- Adjunct Assoc. Prof. of Chemistry & Biochemistry, Georgia Inst. of Tech
- Adjunct Assoc. Prof. of Applied Physiology, Georgia Inst. of Tech
- Adjunct Assoc. Prof. of Physiology, Emory University School of Medicine
Education
Degrees
- PhD from University of TX Health Science Center at Houston
- M.S. from University of North Carolina at Wilmington
- BS from University of Kansas
Research
Focus
- In the McCarty lab, we focus on the molecular physiology of ion channels and receptors, with emphasis on epithelial chloride channels. Our specific focus is the pathophysiology of Cystic Fibrosis, including the structure/function of CFTR and its many roles in the airway. We pioneered the use of peptide toxins as probes of chloride channels.
Publications
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Effects of hyperglycemia on airway epithelial barrier function in WT and CF 16HBE cells.
Sci Rep Volume: 14 Page(s): 25095
10/23/2024 Authors: Vazquez Cegla AJ; Jones KT; Cui G; Cottrill KA; Koval M; McCarty NA -
Flagellum-deficient Pseudomonas aeruginosa is more virulent than non-motile but flagellated mutants in a cystic fibrosis mouse model.
Microbiol Spectr Volume: 12 Page(s): e0132524
10/03/2024 Authors: Moustafa DA; Fantone KM; Tucker SL; McCarty NA; Stecenko AA; Goldberg JB; Rada B -
Chronic hyperglycemia aggravates lung function in a Scnn1b-Tg murine model.
Am J Physiol Lung Cell Mol Physiol Volume: 327 Page(s): L473 - L486
10/01/2024 Authors: Cui G; Moustafa DA; Zhao S; Cegla AV; Lyles JT; Goldberg JB; Chandler JD; McCarty NA -
Development of a programmable automated cell culture system to study the lung pathophysiology of Cystic Fibrosis-related diabetes.
Heliyon Volume: 10 Page(s): e37977
09/30/2024 Authors: Vazquez Cegla AJ; Hedden C; Imhoff BR; Cui G; McCarty NA -
Comparing ATPase activity of ATP-binding cassette subfamily C member 4, lamprey CFTR, and human CFTR using an antimony-phosphomolybdate assay.
Front Pharmacol Volume: 15 Page(s): 1363456
01/01/2024 Authors: Cui G; Strickland KM; Vazquez Cegla AJ; McCarty NA -
A transistor model for the cystic fibrosis transmembrane conductance regulator.
Biophys Rep (N Y) Volume: 3 Page(s): 100108
06/14/2023 Authors: Hunt WD; McCarty NA; Marin EM; Westafer RS; Yamin PR; Cui G; Eckford AW; Denison DR -
Tweaking the catalytic efficiency of the CFTR ion channel.
J Gen Physiol Volume: 155
05/01/2023 Authors: McCarty NA -
Exacerbation-prone pediatric asthma is associated with arginine, lysine, and methionine pathway alterations.
J Allergy Clin Immunol Volume: 151 Page(s): 118 - 127.e10
01/01/2023 Authors: Cottrill KA; Stephenson ST; Mohammad AF; Kim SO; McCarty NA; Kamaleswaran R; Fitzpatrick AM; Chandler JD -
Mathematical models of cystic fibrosis as a systemic disease.
WIREs Mech Dis Volume: 15 Page(s): e1625
01/01/2023 Authors: Olivena DV; Davis JD; Kumbale CM; Zhao CY; Brown SP; McCarty NA; Voit EO -
Permissive and nonpermissive channel closings inCFTR revealed by a factor graph inference algorithm.
Biophys Rep (N Y) Volume: 2 Page(s): 100083
12/14/2022 Authors: Moffett AS; Cui G; Thomas PJ; Hunt WD; McCarty NA; Westafer RS; Eckford AW