Michael Zwick PhD

Department of Human Genetics
Adjunct Professor

615 Michael Street
Suite 331
Atlanta, GA 30322

Overview

My research uses principles of genetics to discover the causes of rare and common disorders. Areas of focus include autism, dystonia, congenital heart defects, early-onset inflammatory bowel disease, and schizophrenia. I lead the All of Us Research Program at Emory University. Precision medicine and cloud computing are also pursued.

As Associate Vice President for Research in the Woodruff Health Sciences Center and Associate Dean for Research in the Emory University School of Medicine, I lead the Emory Integrated Core Facilities (EICF, cores.emory.edu), which includes 16 core facilities and the Division of Animal Resources. The EICF workforce includes 135 scientists and technical staff and directly supports Emory researchers with annual external research funding exceeding 628 million dollars (FY17). I lead the Innovative Discovery portion of the Woodruff Health Sciences Strategic Plan and have play multiple roles in the design and ongoing construction of our newest biomedical research building, HSRB-II (anticipated to open in April 2022)

I am also a former surface warfare qualified officer in the United States Navy (Commander, O-5) who retired in June 2017 with 25 years of service. I served onboard the USS KAUFFMAN (FFG 59) for 38 months and is a veteran of Desert Storm. After duty in large staff units including Commander, Pacific Fleet and Commander, US Forces Japan, I was recalled to active duty in support of the Iraq and Afghanistan war efforts from November 2002 through November 2004, when I was engaged with placing biodefense technologies in the United States Navy fleet and formulating and implementing national biodefense strategies.

Academic Appointment

Associate Vice President for Research, Woodruff Health Sciences Center
Associate Dean for Research, Emory University School of Medicine
Professor of Pediatrics, Department of Pediatrics, Emory University School of Medicine
Professor of Human Genetics, Department of Human Genetics, Emory University School of Medicine

Education

Degrees

PhD from University of California at Davis
BS from Cornell University

Research

Focus

We use cutting-edge genomics technologies to identify rare genetic variation that contributes to common pediatric disorders. Our main areas of interest include autism, congenital heart defects in Down syndrome, early-onset Inflammatory Bowel Disease (IBD), and juvenile arthritis. Develop the technologies necessary to pursue research projects. Investigate the population genomics of biodefense pathogens.

Publications

Correction: Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).
PLoS One Volume: 19 Page(s): e0308819
01/01/2024 Authors: Saba NF; Dinasarapu AR; Magliocca KR; Dwivedi B; Seby S; Qin ZS; Patel M; Griffith CC; Wang X; El-Deiry M
High level of complexity and global diversity of the 3q29 locus revealed by optical mapping and long-read sequencing.
Genome Med Volume: 15 Page(s): 35
05/10/2023 Authors: Yilmaz F; Gurusamy U; Mosley TJ; Hallast P; Kim K; Mostovoy Y; Purcell RH; Shaikh TH; Zwick ME; Kwok P-Y
Investigation of hypertension and type 2 diabetes as risk factors for dementia in the All of Us cohort.
Sci Rep Volume: 12 Page(s): 19797
11/17/2022 Authors: Nagar SD; Pemu P; Qian J; Boerwinkle E; Cicek M; Clark CR; Cohn E; Gebo K; Loperena R; Mayo K
The All of Us Research Program: Data quality, utility, and diversity.
Patterns (N Y) Volume: 3 Page(s): 100570
08/12/2022 Authors: Ramirez AH; Sulieman L; Schlueter DJ; Halvorson A; Qian J; Ratsimbazafy F; Loperena R; Mayo K; Basford M; Deflaux N
Loss of function of OTUD7A in the schizophrenia- associated 15q13.3 deletion impairs synapse development and function in human neurons.
Am J Hum Genet Volume: 109 Page(s): 1500 - 1519
08/04/2022 Authors: Kozlova A; Zhang S; Kotlar AV; Jamison B; Zhang H; Shi S; Forrest MP; McDaid J; Cutler DJ; Epstein MP
Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome.
Proc Natl Acad Sci U S A Volume: 119 Page(s): e2118124119
05/31/2022 Authors: Kong HE; Lim J; Linsalata A; Kang Y; Malik I; Allen EG; Cao Y; Shubeck L; Johnston R; Huang Y
Metabolic effects of the schizophrenia-associated 3q29 deletion.
Transl Psychiatry Volume: 12 Page(s): 66
02/17/2022 Authors: Pollak RM; Purcell RH; Rutkowski TP; Malone T; Pachura KJ; Bassell GJ; Epstein MP; Dawson PA; Smith MR; Jones DP
An Overview of Cancer in the First 315,000 All of Us Participants.
PLoS One Volume: 17 Page(s): e0272522
01/01/2022 Authors: Aschebrook-Kilfoy B; Zakin P; Craver A; Shah S; Kibriya MG; Stepniak E; Ramirez A; Clark C; Cohn E; Ohno-Machado L
Novel Missense CNTNAP2 Variant Identified in Two Consanguineous Pakistani Families With Developmental Delay, Epilepsy, Intellectual Disability, and Aggressive Behavior.
Front Neurol Volume: 13 Page(s): 918022
01/01/2022 Authors: Badshah N; Mattison KA; Ahmad S; Chopra P; Johnston HR; Ahmad S; Khan SH; Sarwar MT; Cutler DJ; Taylor M
Site- and Taxa-Specific Disease-Associated Oral Microbial Structures Distinguish Inflammatory Bowel Diseases.
Inflamm Bowel Dis Volume: 27 Page(s): 1889 - 1900
11/15/2021 Authors: Somineni HK; Weitzner JH; Venkateswaran S; Dodd A; Prince J; Karikaran A; Sauer CG; Abramowicz S; Zwick ME; Cutler DJ
MODELING THE LOSS-OF-FUNCTION MUTATION OF OTUD7A WITHIN THE SCHIZOPHRENIA-ASSOCIATED 15Q13.3 MICRODELETION IN HUMAN NEURONS
Volume: 51 Page(s): E71 - E71
09/27/2021 Authors: Kozlova A; Zhang S; Kotlar A; McDaid J; Forrest MP; Zhang H; Jamison B; Cutler D; Zwick M; Pang Z
Identifying susceptibility genes for primary ovarian insufficiency on the high-risk genetic background of a fragile X premutation.
Fertil Steril Volume: 116 Page(s): 843 - 854
09/01/2021 Authors: Trevino CE; Rounds JC; Charen K; Shubeck L; Hipp HS; Spencer JB; Johnston HR; Cutler DJ; Zwick ME; Epstein MP
Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.
Mol Psychiatry Volume: 26 Page(s): 4496 - 4510
08/01/2021 Authors: Cleynen I; Engchuan W; Hestand MS; Heung T; Holleman AM; Johnston HR; Monfeuga T; McDonald-McGinn DM; Gur RE; Morrow BE
Author Correction: Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Sci Rep Volume: 11 Page(s): 15164
07/20/2021 Authors: Trevino CE; Holleman AM; Corbitt H; Maslen CL; Rosser TC; Cutler DJ; Johnston HR; Rambo-Martin BL; Oberoi J; Dooley KJ
Craniofacial features of 3q29 deletion syndrome: Application of next-generation phenotyping technology.
Am J Med Genet A Volume: 185 Page(s): 2094 - 2101
07/01/2021 Authors: Mak BC; Sanchez Russo R; Gambello MJ; Fleischer N; Black ED; Leslie E; Murphy MM; Emory 3q29 Project; Mulle JG
Staff Scientist Perspectives on Onboarding and Professional Development: A Case Study.
J Biomol Tech Volume: 32 Page(s): 74 - 82
07/01/2021 Authors: Murphy MM; Johnston HR; Zwick ME
Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome.
Transl Psychiatry Volume: 11 Page(s): 357
06/15/2021 Authors: Sefik E; Purcell RH; Emory 3q29 Project; Walker EF; Bassell GJ; Mulle JG
Sex-specific recombination patterns predict parent of origin for recurrent genomic disorders.
BMC Med Genomics Volume: 14 Page(s): 154
06/09/2021 Authors: Mosley TJ; Johnston HR; Cutler DJ; Zwick ME; Mulle JG
Deep phenotyping in 3q29 deletion syndrome: recommendations for clinical care.
Genet Med Volume: 23 Page(s): 872 - 880
05/01/2021 Authors: Sanchez Russo R; Gambello MJ; Murphy MM; Aberizk K; Black E; Burrell TL; Carlock G; Cubells JF; Epstein MT; Espana R
Induced pluripotent stem cells from subjects with Lesch-Nyhan disease.
Sci Rep Volume: 11 Page(s): 8523
04/19/2021 Authors: Sutcliffe DJ; Dinasarapu AR; Visser JE; Hoed JD; Seifar F; Joshi P; Ceballos-Picot I; Sardar T; Hess EJ; Sun YV
Organizing core facilities as force multipliers: strategies for research universities.
J Biomol Tech Volume: 32 Page(s): 36 - 41
04/01/2021 Authors: Zwick ME
Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease.
Am J Hum Genet Volume: 108 Page(s): 431 - 445
03/04/2021 Authors: Somineni HK; Nagpal S; Venkateswaran S; Cutler DJ; Okou DT; Haritunians T; Simpson CL; Begum F; Datta LW; Quiros AJ
Organizing core facilities as force multipliers: strategies for research universities.
J Biomol Tech
01/15/2021 Authors: Zwick ME
Bayesian Pathway Analysis for Complex Interactions.
Am J Epidemiol Volume: 189 Page(s): 1610 - 1622
12/01/2020 Authors: Baurley JW; Kjrsgaard A; Zwick ME; Cronin-Fenton DP; Collin LJ; Damkier P; Hamilton-Dutoit S; Lash TL; Ahern TP
Identifying genetic factors that contribute to the increased risk of congenital heart defects in infants with Down syndrome.
Sci Rep Volume: 10 Page(s): 18051
10/22/2020 Authors: Trevino CE; Holleman AM; Corbitt H; Maslen CL; Rosser TC; Cutler DJ; Johnston HR; Rambo-Martin BL; Oberoi J; Dooley KJ
The Emory Integrated Core Facilities: Force Multipliers for Research.
J Biomol Tech Volume: 31 Page(s): S3
08/01/2020 Authors: Zwick M
New phenotypes associated with 3q29 duplication syndrome: Results from the 3q29 registry.
Am J Med Genet A Volume: 182 Page(s): 1152 - 1166
05/01/2020 Authors: Pollak RM; Zinsmeister MC; Murphy MM; Zwick ME; Emory 3q29 Project; Mulle JG
Comprehensive phenotyping of neuropsychiatric traits in a multiplex 3q29 deletion family: a case report.
BMC Psychiatry Volume: 20 Page(s): 184
04/22/2020 Authors: Murphy MM; Burrell TL; Cubells JF; Epstein MT; Espana R; Gambello MJ; Goines K; Klaiman C; Koh S; Russo RS
Metabolic Pathway Analysis and Effectiveness of Tamoxifen in Danish Breast Cancer Patients.
Cancer Epidemiol Biomarkers Prev Volume: 29 Page(s): 582 - 590
03/01/2020 Authors: Ahern TP; Collin LJ; Baurley JW; Kjrsgaard A; Nash R; Maliniak ML; Damkier P; Zwick ME; Isett RB; Christiansen PM
Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism.
Cell Volume: 180 Page(s): 568 - 584.e23
02/06/2020 Authors: Satterstrom FK; Kosmicki JA; Wang J; Breen MS; De Rubeis S; An J-Y; Peng M; Collins R; Grove J; Klei L
Complete Sequence of the 22q11.2 Allele in 1,053 Subjects with 22q11.2 Deletion Syndrome Reveals Modifiers of Conotruncal Heart Defects.
Am J Hum Genet Volume: 106 Page(s): 26 - 40
01/02/2020 Authors: Zhao Y; Diacou A; Johnston HR; Musfee FI; McDonald-McGinn DM; McGinn D; Crowley TB; Repetto GM; Swillen A; Breckpot J
Signatures of somatic mutations and gene expression from p16INK4A positive head and neck squamous cell carcinomas (HNSCC).
PLoS One Volume: 15 Page(s): e0238497
01/01/2020 Authors: Saba NF; Dinasarapu AR; Magliocca KR; Dwivedi B; Seby S; Qin ZS; Patel M; Griffith CC; Wang X; El-Deiry M
Multi-Institutional Core Collaborations.
J Biomol Tech Volume: 30 Page(s): S56
12/01/2019 Authors: Colella T; Ambulos NP; Chow E; Russell W; Zwick ME
Inherited genetic susceptibility to acute lymphoblastic leukemia in Down syndrome.
Blood Volume: 134 Page(s): 1227 - 1237
10/10/2019 Authors: Brown AL; de Smith AJ; Gant VU; Yang W; Scheurer ME; Walsh KM; Chernus JM; Kallsen NA; Peyton SA; Davies GE
METABOLIC DYSFUNCTION AS A CONTRIBUTOR TO PHENOTYPES OF THE SCHIZOPHRENIA-ASSOCIATED 3Q29 DELETION
Volume: 29 Page(s): S224 - S225
10/01/2019 Authors: Pollak R; Purcell R; Rutkowski T; Malone T; Pachura K; Bassell GJ; Epstein MP; Caspary T; Dawson PA; Jones DP
Neutrophil GM-CSF signaling in inflammatory bowel disease patients is influenced by non-coding genetic variants.
Sci Rep Volume: 9 Page(s): 9168
06/24/2019 Authors: Venkateswaran S; Denson LA; Jurickova I; Dodd A; Zwick ME; Cutler DJ; Kugathasan S; Okou DT
WHOLE-GENOME SEQUENCING OF AFRICAN AMERICANS IDENTIFIES NOVEL RARE VARIANTS ASSOCIATED WITH INFLAMMATORY BOWEL
Volume: 156 Page(s): S488 - S489
05/01/2019 Authors: Somineni HK; Haritunians T; Simpson CL; Cutler DJ; Okou D; Itan Y; Venkateswaran S; Stevens C; Datta LW; Dhere TA
Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease.
Inflamm Bowel Dis Volume: 25 Page(s): 547 - 560
02/21/2019 Authors: Denson LA; Jurickova I; Karns R; Shaw KA; Cutler DJ; Okou D; Valencia CA; Dodd A; Mondal K; Aronow BJ
Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort.
Genes Immun Volume: 20 Page(s): 131 - 142
02/01/2019 Authors: Shaw KA; Cutler DJ; Okou D; Dodd A; Aronow BJ; Haberman Y; Stevens C; Walters TD; Griffiths A; Baldassano RN
Neuropsychiatric phenotypes and a distinct constellation of ASD features in 3q29 deletion syndrome: results from the 3q29 registry.
Mol Autism Volume: 10 Page(s): 30
01/01/2019 Authors: Pollak RM; Murphy MM; Epstein MP; Zwick ME; Klaiman C; Saulnier CA; Emory 3q29 Project; Mulle JG
THE EMORY 3Q29 DELETION PROJECT: PROFILES OF NEURODEVELOPMENTAL AND NEUROPSYCHIATRIC PHENOTYPES
Volume: 29 Page(s): S830 - S830
01/01/2019 Authors: Pollak R; Boddu S; Park J; Zwick M; Saulnier C; Mulle J
Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects.
Am J Med Genet A Volume: 176 Page(s): 2172 - 2181
10/01/2018 Authors: Zhao Y; Guo T; Fiksinski A; Breetvelt E; McDonald-McGinn DM; Crowley TB; Diacou A; Schneider M; Eliez S; Swillen A
Modeling DYT1 Dystonia Using Induced Pluripotent Stem Cells
Volume: 84 Page(s): S198 - S199
10/01/2018 Authors: Dinasarapu AR; Sutcliffe DJ; Zwick ME; Jinnah HA
Common Polymorphism in Bdnfrs6265 May Impact Treatment Response to Deep Brain Stimulation versus Optimal Drug Therapy in Parkinson's Disease
Volume: 84 Page(s): S97 - S97
10/01/2018 Authors: Sutcliffe DJ; Dinasarapu AR; Zwick ME; Jinnah HA
Retraction Notice to: Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements.
Am J Hum Genet Volume: 103 Page(s): 457
09/06/2018 Authors: Demaerel W; Hestand MS; Vergaelen E; Swillen A; Lpez-Snchez M; Prez-Jurado LA; McDonald-McGinn DM; Zackai E; Emanuel BS; Morrow BE
Genome-wide association study of acute lymphoblastic leukemia in children with Down syndrome
Volume: 78
07/01/2018 Authors: Brown AL; de Smith AJ; Scheurer ME; Kallsen NA; Peyton SA; Davies GE; Ehli EA; Zwick ME; Winick N; Maloney K
Clinical and Genomic Correlates of Neutrophil Reactive Oxygen Species Production in Pediatric Patients With Crohn's Disease.
Gastroenterology Volume: 154 Page(s): 2097 - 2110
06/01/2018 Authors: Denson LA; Jurickova I; Karns R; Shaw KA; Cutler DJ; Okou DT; Dodd A; Quinn K; Mondal K; Aronow BJ
GENOMIC CORRELATES OF REDUCED NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN STRICTURING PEDIATRIC CROHN DISEASE
Volume: 154 Page(s): S89 - S90
05/01/2018 Authors: Jurickova I; Karns R; Cutler DJ; Okou D; Dodd A; Mondal K; Aronow BJ; Haberman Y; Linn A; Price A
The Neuropsychiatric and Behavioral Phenotypes of 3q29 Deletion Syndrome
Volume: 83 Page(s): S262 - S262
05/01/2018 Authors: Pollak R; Murphy M; Epstein M; Zwick M; Saulnier C; Mulle J
Enhanced Contribution of HLA in Pediatric Onset Ulcerative Colitis.
Inflamm Bowel Dis Volume: 24 Page(s): 829 - 838
03/19/2018 Authors: Venkateswaran S; Prince J; Cutler DJ; Marigorta UM; Okou DT; Prahalad S; Mack D; Boyle B; Walters T; Griffiths A
Bystro: rapid online variant annotation and natural-language filtering at whole-genome scale.
Genome Biol Volume: 19 Page(s): 14
02/06/2018 Authors: Kotlar AV; Trevino CE; Zwick ME; Cutler DJ; Wingo TS
CLINICAL AND GENOMIC CORRELATES OF NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN PEDIATRIC CROHN DISEASE
Volume: 24 Page(s): S7 - S8
02/01/2018 Authors: Denson LA; Jurickova I; Karns R; Shaw KA; Cutler DJ; Okou D; Dodd A; Mondal K; Aronow BJ; Haberman Y
Analysis of Copy Number Variants on Chromosome 21 in Down Syndrome-Associated Congenital Heart Defects.
G3 (Bethesda) Volume: 8 Page(s): 105 - 111
01/04/2018 Authors: Rambo-Martin BL; Mulle JG; Cutler DJ; Bean LJH; Rosser TC; Dooley KJ; Cua C; Capone G; Maslen CL; Reeves RH
CLINICAL AND GENOMIC CORRELATES OF NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IN PEDIATRIC CROHN DISEASE
Volume: 154 Page(s): S10 - S11
01/01/2018 Authors: Denson LA; Jurickova I; Karns R; Shaw KA; Cutler DJ; Okou D; Dodd A; Mondal K; Aronow BJ; Haberman Y
Nested Inversion Polymorphisms Predispose Chromosome 22q11.2 to Meiotic Rearrangements.
Am J Hum Genet Volume: 101 Page(s): 616 - 622
10/05/2017 Authors: Demaerel W; Hestand MS; Vergaelen E; Swillen A; Lpez-Snchez M; Prez-Jurado LA; McDonald-McGinn DM; Zackai E; Emanuel BS; Morrow BE
Reply to Plss et al.: The strength of PEMapper/PECaller lies in unbiased calling using large sample sizes.
Proc Natl Acad Sci U S A Volume: 114 Page(s): E8323
10/03/2017 Authors: Johnston HR; Chopra P; Wingo TS; Patel V; Epstein MP; Mulle JG; Warren ST; Zwick ME; Cutler DJ
Omicseq: a web-based search engine for exploring omics datasets.
Nucleic Acids Res Volume: 45 Page(s): W445 - W452
07/03/2017 Authors: Sun X; Pittard WS; Xu T; Chen L; Zwick ME; Jiang X; Wang F; Qin ZS
LOW NEUTROPHIL REACTIVE OXYGEN SPECIES PRODUCTION IS ASSOCIATED WITH NICOTINAMIDE-ADENINE DINUCLEOTIDE PHOSPHATE (NADPH) OXIDASE GENE MUTATIONS AND REFRACTORY COLONIC INVOLVEMENT IN PEDIATRIC CROHN DISEASE
Volume: 152 Page(s): S955 - S955
04/01/2017 Authors: Denson LA; Jurickova I; Shaw K; Linn A; Dodd A; Okou D; Chalk C; Bonkowski E; Griffiths AM; Baldassano RN
REDUCED NEUTROPHIL GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR SIGNALING IS ASSOCIATED WITH GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR ALPHA CHAIN GENE MUTATIONS AND STRICTURING DISEASE COMPLICATIONS IN PEDIATRIC CROHN DISEASE
Volume: 152 Page(s): S955 - S955
04/01/2017 Authors: Denson LA; Jurickova I; Shaw K; Linn A; Dodd A; Okou D; Chalk C; Bonkowski E; Griffiths AM; Baldassano RN
PEMapper and PECaller provide a simplified approach to whole-genome sequencing.
Proc Natl Acad Sci U S A Volume: 114 Page(s): E1923 - E1932
03/07/2017 Authors: Johnston HR; Chopra P; Wingo TS; Patel V; International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome; Epstein MP; Mulle JG; Warren ST; Zwick ME; Cutler DJ
Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.
Gastroenterology Volume: 152 Page(s): 206 - 217.e2
01/01/2017 Authors: Brant SR; Okou DT; Simpson CL; Cutler DJ; Haritunians T; Bradfield JP; Chopra P; Prince J; Begum F; Kumar A
Dysbiosis, inflammation, and response to treatment: a longitudinal study of pediatric subjects with newly diagnosed inflammatory bowel disease.
Genome Med Volume: 8 Page(s): 75
07/13/2016 Authors: Shaw KA; Bertha M; Hofmekler T; Chopra P; Vatanen T; Srivatsa A; Prince J; Kumar A; Sauer C; Zwick ME
Novel features of 3q29 deletion syndrome: Results from the 3q29 registry.
Am J Med Genet A Volume: 170A Page(s): 999 - 1006
04/01/2016 Authors: Glassford MR; Rosenfeld JA; Freedman AA; Zwick ME; Mulle JG; Unique Rare Chromosome Disorder Support Group
New discoveries in schizophrenia genetics reveal neurobiological pathways: A review of recent findings.
Eur J Med Genet Volume: 58 Page(s): 704 - 714
12/01/2015 Authors: Kotlar AV; Mercer KB; Zwick ME; Mulle JG
Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans.
Gastroenterology Volume: 149 Page(s): 1575 - 1586
11/01/2015 Authors: Huang C; Haritunians T; Okou DT; Cutler DJ; Zwick ME; Taylor KD; Datta LW; Maranville JC; Liu Z; Ellis S
Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci.
Neuron Volume: 87 Page(s): 1215 - 1233
09/23/2015 Authors: Sanders SJ; He X; Willsey AJ; Ercan-Sencicek AG; Samocha KE; Cicek AE; Murtha MT; Bal VH; Bishop SL; Dong S
Genome-Wide Association Study of Down Syndrome-Associated Atrioventricular Septal Defects.
G3 (Bethesda) Volume: 5 Page(s): 1961 - 1971
07/20/2015 Authors: Ramachandran D; Zeng Z; Locke AE; Mulle JG; Bean LJH; Rosser TC; Dooley KJ; Cua CL; Capone GT; Reeves RH
Contribution of copy-number variation to Down syndrome-associated atrioventricular septal defects.
Genet Med Volume: 17 Page(s): 554 - 560
07/01/2015 Authors: Ramachandran D; Mulle JG; Locke AE; Bean LJH; Rosser TC; Bose P; Dooley KJ; Cua CL; Capone GT; Reeves RH
Immunochip Implicates Multiple Genetic Loci for African American IBD Including HLA-DRB1*1502 for UC, NOD2, PTGER4, IL23R, LZKF3 and STAT5A/STAT3 for CD and Several Regions of Significant Admixture Linkage Disequilibrium
Volume: 148 Page(s): S80 - S80
04/01/2015 Authors: Brant SR; Huang C; Haritunians T; Okou DT; Cutler DJ; Zwick ME; Datta LW; Taylor KD; Rotter JI; Bridges SL
Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping.
PLoS One Volume: 10 Page(s): e0128074
01/01/2015 Authors: Cutler DJ; Zwick ME; Okou DT; Prahalad S; Walters T; Guthery SL; Dubinsky M; Baldassano R; Crandall WV; Rosh J
A De Novo Variant in Galactose-1-P Uridylyltransferase (GALT) Leading to Classic Galactosemia.
JIMD Rep Volume: 19 Page(s): 1 - 6
01/01/2015 Authors: Tran T-TCV; Liu Y; Zwick ME; Ramachandran D; Cutler DJ; Huang X; Berry GT; Fridovich-Keil JL
Synaptic, transcriptional and chromatin genes disrupted in autism.
Nature Volume: 515 Page(s): 209 - 215
11/13/2014 Authors: De Rubeis S; He X; Goldberg AP; Poultney CS; Samocha K; Cicek AE; Kou Y; Liu L; Fromer M; Walker S
Exome sequencing identifies a novel FOXP3 mutation in a 2-generation family with inflammatory bowel disease.
J Pediatr Gastroenterol Nutr Volume: 58 Page(s): 561 - 568
05/01/2014 Authors: Okou DT; Mondal K; Faubion WA; Kobrynski LJ; Denson LA; Mulle JG; Ramachandran D; Xiong Y; Svingen P; Patel V
Variant ATRX syndrome with dysfunction of ATRX and MAGT1 genes.
Hum Mutat Volume: 35 Page(s): 58 - 62
01/01/2014 Authors: Qiao Y; Mondal K; Trapani V; Wen J; Carpenter G; Wildin R; Price EM; Gibbons RJ; Eichmeyer J; Jiang R
Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.
Arthritis Rheum Volume: 65 Page(s): 1663 - 1667
06/01/2013 Authors: Prahalad S; Conneely KN; Jiang Y; Sudman M; Wallace CA; Brown MR; Ponder LA; Rohani-Pichavant M; Zwick ME; Cutler DJ
Early Onset Crohn's Disease Exhibit Distinct Allele Architecture Differences and Reveal New IBD Loci
Volume: 144 Page(s): S178 - S178
05/01/2013 Authors: Kugathasan S; Dubinsky M; Guthery SL; Okou DT; Bose P; Zwick ME; Cutler DJ; Waters JP; Hyams JS; Baldassano R
Exome Sequencing Identify Novel Variants in African-Americans With Severe Perianal and Colonic Crohn's Disease
Volume: 144 Page(s): S465 - S465
05/01/2013 Authors: Kugathasan S; Okou DT; Mondal K; Benjamin AL; Kumar A; Hussain SZ; Katz J; Cross R; Moulton DE; Cutler DJ
Evaluating rare variants in complex disorders using next-generation sequencing.
Curr Psychiatry Rep Volume: 15 Page(s): 349
04/01/2013 Authors: Ezewudo M; Zwick ME
The autism sequencing consortium: large-scale, high-throughput sequencing in autism spectrum disorders.
Neuron Volume: 76 Page(s): 1052 - 1056
12/20/2012 Authors: Buxbaum JD; Daly MJ; Devlin B; Lehner T; Roeder K; State MW; Autism Sequencing Consortium
Common NOD2 risk variants in African Americans with Crohn's disease are due exclusively to recent Caucasian admixture.
Inflamm Bowel Dis Volume: 18 Page(s): 2357 - 2359
12/01/2012 Authors: Adeyanju O; Okou DT; Huang C; Kumar A; Sauer C; Galloway C; Prasad M; Waters J; Cutler DJ; Zwick ME
Testing Copy Number Variant/Trait Associations Detected Using Manhattan Plots
Volume: 36 Page(s): 767 - 767
11/01/2012 Authors: Satten GA; Ramachandran D; Mulle JG; Allen AS; Bean LJH; Maslen C; Sherman SL; Reeves RH; Zwick ME
Excess variants in AFF2 detected by massively parallel sequencing of males with autism spectrum disorder.
Hum Mol Genet Volume: 21 Page(s): 4356 - 4364
10/01/2012 Authors: Mondal K; Ramachandran D; Patel VC; Hagen KR; Bose P; Cutler DJ; Zwick ME
Identification of rare X-linked neuroligin variants by massively parallel sequencing in males with autism spectrum disorder.
Mol Autism Volume: 3 Page(s): 8
09/28/2012 Authors: Steinberg KM; Ramachandran D; Patel VC; Shetty AC; Cutler DJ; Zwick ME
Genomic characterization of the Bacillus cereus sensu lato species: backdrop to the evolution of Bacillus anthracis.
Genome Res Volume: 22 Page(s): 1512 - 1524
08/01/2012 Authors: Zwick ME; Joseph SJ; Didelot X; Chen PE; Bishop-Lilly KA; Stewart AC; Willner K; Nolan N; Lentz S; Thomason MK
Disruption of RAB40AL function leads to Martin--Probst syndrome, a rare X-linked multisystem neurodevelopmental human disorder.
J Med Genet Volume: 49 Page(s): 332 - 340
05/01/2012 Authors: Bedoyan JK; Schaibley VM; Peng W; Bai Y; Mondal K; Shetty AC; Durham M; Micucci JA; Dhiraaj A; Skidmore JM
Multiplex Chromosomal Exome Sequencing Accelerates Identification of ENU-Induced Mutations in the Mouse.
G3 (Bethesda) Volume: 2 Page(s): 143 - 150
01/01/2012 Authors: Sun M; Mondal K; Patel V; Horner VL; Long AB; Cutler DJ; Caspary T; Zwick ME
Risk of NOD2 in African-American subjects with Crohn's disease is exclusively contributed by Caucasian admixture
INFLAMMATORY BOWEL DISEASES Volume: 17 Page(s): S77 - S78
12/01/2011 Authors: Adeyanju O; Okou D; Huang C; Sauer C; Prasad M; Waters J; Ifeadike W; Benjamin A; Labaze S; Cutler D
Targeted sequencing of the human X chromosome exome.
Genomics Volume: 98 Page(s): 260 - 265
10/01/2011 Authors: Mondal K; Shetty AC; Patel V; Cutler DJ; Zwick ME
Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay.
J Clin Invest Volume: 121 Page(s): 976 - 984
03/01/2011 Authors: He M; Kratz LE; Michel JJ; Vallejo AN; Ferris L; Kelley RI; Hoover JJ; Jukic D; Gibson KM; Wolfe LA
Genetic variation and linkage disequilibrium in Bacillus anthracis.
Sci Rep Volume: 1 Page(s): 169
01/01/2011 Authors: Zwick ME; Thomason MK; Chen PE; Johnson HR; Sozhamannan S; Mateczun A; Read TD
Microarray oligonucleotide probe designer (MOPeD): A web service.
Open Access Bioinformatics Volume: 2 Page(s): 145 - 155
11/01/2010 Authors: Patel VC; Mondal K; Shetty AC; Horner VL; Bedoyan JK; Martin D; Caspary T; Cutler DJ; Zwick ME
Identification of novel FMR1 variants by massively parallel sequencing in developmentally delayed males.
Am J Med Genet A Volume: 152A Page(s): 2512 - 2520
10/01/2010 Authors: Collins SC; Bray SM; Suhl JA; Cutler DJ; Coffee B; Zwick ME; Warren ST
SeqAnt: a web service to rapidly identify and annotate DNA sequence variations.
BMC Bioinformatics Volume: 11 Page(s): 471
09/20/2010 Authors: Shetty AC; Athri P; Mondal K; Horner VL; Steinberg KM; Patel V; Caspary T; Cutler DJ; Zwick ME
Rapid identification of genetic modifications in Bacillus anthracis using whole genome draft sequences generated by 454 pyrosequencing.
PLoS One Volume: 5 Page(s): e12397
08/25/2010 Authors: Chen PE; Willner KM; Butani A; Dorsey S; George M; Stewart A; Lentz SM; Cook CE; Akmal A; Price LB
Empirical evaluation of oligonucleotide probe selection for DNA microarrays.
PLoS One Volume: 5 Page(s): e9921
03/29/2010 Authors: Mulle JG; Patel VC; Warren ST; Hegde MR; Cutler DJ; Zwick ME
Array-based FMR1 sequencing and deletion analysis in patients with a fragile X syndrome-like phenotype.
PLoS One Volume: 5 Page(s): e9476
03/05/2010 Authors: Collins SC; Coffee B; Benke PJ; Berry-Kravis E; Gilbert F; Oostra B; Halley D; Zwick ME; Cutler DJ; Warren ST
Copy number abnormalities in sporadic canine colorectal cancers.
Genome Res Volume: 20 Page(s): 341 - 350
03/01/2010 Authors: Tang J; Le S; Sun L; Yan X; Zhang M; Macleod J; Leroy B; Northrup N; Ellis A; Yeatman TJ
Genomic characterization of the Yersinia genus.
Genome Biol Volume: 11 Page(s): R1
01/04/2010 Authors: Chen PE; Cook C; Stewart AC; Nagarajan N; Sommer DD; Pop M; Thomason B; Thomason MPK; Lentz S; Nolan N
Combining microarray-based genomic selection (MGS) with the Illumina Genome Analyzer platform to sequence diploid target regions.
Ann Hum Genet Volume: 73 Page(s): 502 - 513
09/01/2009 Authors: Okou DT; Locke AE; Steinberg KM; Hagen K; Athri P; Shetty AC; Patel V; Zwick ME
Structure and complexity of a bacterial transcriptome.
J Bacteriol Volume: 191 Page(s): 3203 - 3211
05/01/2009 Authors: Passalacqua KD; Varadarajan A; Ondov BD; Okou DT; Zwick ME; Bergman NH
Microarray-based mutation detection in the dystrophin gene.
Hum Mutat Volume: 29 Page(s): 1091 - 1099
09/01/2008 Authors: Hegde MR; Chin ELH; Mulle JG; Okou DT; Warren ST; Zwick ME
Genotyping of Bacillus cereus strains by microarray-based resequencing.
PLoS One Volume: 3 Page(s): e2513
07/02/2008 Authors: Zwick ME; Kiley MP; Stewart AC; Mateczun A; Read TD
Applying rapid genome sequencing technologies to characterize pathogen genomes.
Anal Chem Volume: 80 Page(s): 520 - 528
02/01/2008 Authors: Steinberg KM; Okou DT; Zwick ME
Microarray-based genomic selection for high-throughput resequencing.
Nat Methods Volume: 4 Page(s): 907 - 909
11/01/2007 Authors: Okou DT; Steinberg KM; Middle C; Cutler DJ; Albert TJ; Zwick ME
A genome sequencing center in every lab.
Eur J Hum Genet Volume: 13 Page(s): 1167 - 1168
11/01/2005 Authors: Zwick ME
Microarray-based resequencing of multiple Bacillus anthracis isolates.
Genome Biol Volume: 6 Page(s): R10
01/01/2005 Authors: Zwick ME; Mcafee F; Cutler DJ; Read TD; Ravel J; Bowman GR; Galloway DR; Mateczun A
Discrepancies in dbSNP confirmation rates and allele frequency distributions from varying genotyping error rates and patterns.
Bioinformatics Volume: 20 Page(s): 1022 - 1032
05/01/2004 Authors: Mitchell AA; Zwick ME; Chakravarti A; Cutler DJ
Haplotype inference in random population samples.
Am J Hum Genet Volume: 71 Page(s): 1129 - 1137
11/01/2002 Authors: Lin S; Cutler DJ; Zwick ME; Chakravarti A
Variation across the X chromosome.
Volume: 71 Page(s): 206 - 206
10/01/2002 Authors: Mathews DJ; Cutler DJ; Zwick ME; Chakravarti A
An empirical estimate of the number of SNPs required for a whole genome association study.
Volume: 71 Page(s): 219 - 219
10/01/2002 Authors: Zwick ME; Cutler DJ; Lin S; Chakravarti A
High-throughput variation detection and genotyping using microarrays.
Genome Res Volume: 11 Page(s): 1913 - 1925
11/01/2001 Authors: Cutler DJ; Zwick ME; Carrasquillo MM; Yohn CT; Tobin KP; Kashuk C; Mathews DJ; Shah NA; Eichler EE; Warrington JA
Linkage disequilibrium within and between multiple X and autosomal genomic regions.
AMERICAN JOURNAL OF HUMAN GENETICS Volume: 69 Page(s): 219 - 219
10/01/2001 Authors: Zwick ME; Cutter DJ; Yohn CT; Tobin KP; Kashuk C; Shah N; Warrington J; Chakravarti A
Human population substructure and its influence on association studies.
Volume: 69 Page(s): 181 - 181
10/01/2001 Authors: Cutler DJ; Zwick ME; Yohn CT; Tobin KP; Kashuk C; Shah NA; Warrington JA; Chakravarti A
Characterizing human genomic variation and linkage disequilibrium in multiple 100kb genomic segments using large-scale, microarray-based SNP detection.
Volume: 67 Page(s): 22 - 22
10/01/2000 Authors: Zwick ME; Cutler DJ; Yohn CT; Tobin KP; Kashuk CS; Shah NA; Warrington JA; Eichler EE; Chakravarti A
Patterns of genetic variation in Mendelian and complex traits.
Volume: 1 Page(s): 387 - 407
01/01/2000 Authors: Zwick ME; Cutler DJ; Chakravarti A
Classic Weinstein: tetrad analysis, genetic variation and achiasmate segregation in Drosophila and humans.
Genetics Volume: 152 Page(s): 1615 - 1629
08/01/1999 Authors: Zwick ME; Cutler DJ; Langley CH
Genetic variation in rates of nondisjunction: association of two naturally occurring polymorphisms in the chromokinesin nod with increased rates of nondisjunction in Drosophila melanogaster.
Genetics Volume: 152 Page(s): 1605 - 1614
08/01/1999 Authors: Zwick ME; Salstrom JL; Langley CH
Mitochondrial DNA in the bark weevils: size, structure and heteroplasmy.
Genetics Volume: 123 Page(s): 825 - 836
12/01/1989 Authors: Boyce TM; Zwick ME; Aquadro CF

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