Muxiang Zhou MD

Department of Pediatrics
Professor

Aflac Cancer and Blood Disorders Center
Pediatrics
1760 Haygood Drive

Academic Appointment

Professor of Pediatrics, Emory University

Education

Degrees

MD from Tongji Medical University

Research

Focus

The major focus of research has been the molecular analysis and identification of signaling pathways that confer cancer promotion and development of anticancer resistance, which aims to exploit innovative approach and novel drugs for targeting cancer therapeutics.

Publications

An MDM2 degrader shows potent cytotoxicity to MDM2-overexpressing acute lymphoblastic leukemia cells with minimal toxicity to normal cells/tissues.
Cancer Lett Volume: 598 Page(s): 217126
08/28/2024 Authors: Liu T; Gu L; Mui A; Wu Z; Albadari N; Li W; Zhou M
Synthesis and biological evaluation of dual MDM2/XIAP inhibitors based on the tetrahydroquinoline scaffold.
Eur J Med Chem Volume: 255 Page(s): 115423
07/05/2023 Authors: Albadari N; Xie Y; Liu T; Wang R; Gu L; Zhou M; Wu Z; Li W
MYCN mRNA degradation and cancer suppression by a selective small-molecule inhibitor in MYCN-amplified neuroblastoma.
Front Oncol Volume: 12 Page(s): 1058726
01/01/2022 Authors: Liu T; Gu L; Wu Z; Albadari N; Li W; Zhou M
Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor.
J Med Chem Volume: 64 Page(s): 1930 - 1950
02/25/2021 Authors: Wu Z; Gu L; Zhang S; Liu T; Lukka PB; Meibohm B; Bollinger JC; Zhou M; Li W
Upregulation of p53 through induction of MDM2 degradation: Anthraquinone analogs.
Bioorg Med Chem Volume: 27 Page(s): 3860 - 3865
09/01/2019 Authors: Draganov AB; Yang X; Anifowose A; De La Cruz LKC; Dai C; Ni N; Chen W; De Los Santos Z; Gu L; Zhou M
Mutual regulation of MDM4 and TOP2A in cancer cell proliferation
Volume: 79
07/01/2019 Authors: Liu T; Zhang H; Yi S; Gu L; Zhou M
Mutual regulation of MDM4 and TOP2A in cancer cell proliferation.
Mol Oncol Volume: 13 Page(s): 1047 - 1058
05/01/2019 Authors: Liu T; Zhang H; Yi S; Gu L; Zhou M
Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice.
Mol Cancer Ther Volume: 17 Page(s): 497 - 507
02/01/2018 Authors: Gu L; Zhang H; Liu T; Draganov A; Yi S; Wang B; Zhou M
FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2.
Oncogene Volume: 36 Page(s): 1678 - 1686
03/23/2017 Authors: Liu T; Xiong J; Yi S; Zhang H; Zhou S; Gu L; Zhou M
Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment.
Nature Volume: 539 Page(s): 304 - 308
11/10/2016 Authors: Dong L; Yu W-M; Zheng H; Loh ML; Bunting ST; Pauly M; Huang G; Zhou M; Broxmeyer HE; Scadden DT
Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment.
Cancer Cell Volume: 30 Page(s): 623 - 636
10/10/2016 Authors: Gu L; Zhang H; Liu T; Zhou S; Du Y; Xiong J; Yi S; Qu C-K; Fu H; Zhou M
Targeting MYCN IRES in MYCN-amplified neuroblastoma with miR-375 inhibits tumor growth and sensitizes tumor cells to radiation.
Mol Oncol Volume: 9 Page(s): 1301 - 1311
08/01/2015 Authors: Zhang H; Liu T; Yi S; Gu L; Zhou M
Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival.
Mol Cancer Volume: 14 Page(s): 65
03/26/2015 Authors: Liu T; Zhang H; Xiong J; Yi S; Gu L; Zhou M
Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemia.
PLoS One Volume: 9 Page(s): e100960
01/01/2014 Authors: Zhang H; Gu L; Liu T; Chiang K-Y; Zhou M
Berberine represses DAXX gene transcription and induces cancer cell apoptosis.
Lab Invest Volume: 93 Page(s): 354 - 364
03/01/2013 Authors: Li J; Gu L; Zhang H; Liu T; Tian D; Zhou M; Zhou S
Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway.
Mol Cancer Ther Volume: 12 Page(s): 184 - 194
02/01/2013 Authors: Huang M; Zhang H; Liu T; Tian D; Gu L; Zhou M
Methylation of RASSF1A gene promoter is regulated by p53 and DAXX.
FASEB J Volume: 27 Page(s): 232 - 242
01/01/2013 Authors: Zhang H; He J; Li J; Tian D; Gu L; Zhou M
Polysome Preparation, RNA Isolation and Analysis.
Bio Protoc Volume: 2
10/05/2012 Authors: Zhang H; Zhou M
Effect of gender on the production of autoantibodies to meningioma antigens
Volume: 259 Page(s): S45 - S45
06/01/2012 Authors: Wiemels J; Bracchi P; Wrensch M; Schildkraut J; Bondy M; Pfefferle J; Zhou M; Sison J; Calvocoressi L; Claus EB
MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells.
Oncogene Volume: 31 Page(s): 1342 - 1353
03/15/2012 Authors: Gu L; Zhang H; He J; Li J; Huang M; Zhou M
MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia.
Mol Cell Biol Volume: 31 Page(s): 4928 - 4937
12/01/2011 Authors: Zhou S; Gu L; He J; Zhang H; Zhou M
Crosstalk between MYCN and MDM2-p53 signal pathways regulates tumor cell growth and apoptosis in neuroblastoma.
Cell Cycle Volume: 10 Page(s): 2994 - 3002
09/01/2011 Authors: He J; Gu L; Zhang H; Zhou M
Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells.
Cancer Res Volume: 70 Page(s): 9895 - 9904
12/01/2010 Authors: Zhang X; Gu L; Li J; Shah N; He J; Yang L; Hu Q; Zhou M
Berberine Induces Apoptosis In Acute Lymphoblastic Leukemia Cells by Demethylation of RASSF1A and Self-Ubiquitination of MDM2
Volume: 116 Page(s): 1492 - 1493
11/19/2010 Authors: Me J; Zhang H; Li J; Gu L; Zhou M
Translation of TRAF1 is regulated by IRES-dependent mechanism and stimulated by vincristine.
Nucleic Acids Res Volume: 38 Page(s): 4503 - 4513
07/01/2010 Authors: Yang L; Gu L; Li Z; Zhou M
Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types.
J Exp Clin Cancer Res Volume: 29 Page(s): 8
01/22/2010 Authors: Ling X; Calinski D; Chanan-Khan AA; Zhou M; Li F
Expression of TNF-alpha leader sequence renders MCF-7 tumor cells resistant to the cytotoxicity of soluble TNF-alpha.
Breast Cancer Res Treat Volume: 116 Page(s): 91 - 102
07/01/2009 Authors: Yan D; Qin N; Zhang H; Liu T; Yu M; Jiang X; Feng W; Wang J; Yin B; Zhang T
Regulation of XIAP translation and induction by MDM2 following irradiation.
Cancer Cell Volume: 15 Page(s): 363 - 375
05/05/2009 Authors: Gu L; Zhu N; Zhang H; Durden DL; Feng Y; Zhou M
MDM2 silencing downregulates XIAP, enhancing sensitivity of human neuroblastoma cells to etoposide
CANCER RESEARCH Volume: 69
05/01/2009 Authors: Zhu N; Gu L; He J; Zhou M
Vincristine induces apoptosis in acute lymphoblastic leukemia cells through upregulation of TRAF1 and downregulation of NF-kB
CANCER RESEARCH Volume: 69
05/01/2009 Authors: Gu L; Yang L; Zhou M
Glycogen synthase kinase 3beta induces apoptosis in cancer cells through increase of survivin nuclear localization.
Cancer Lett Volume: 272 Page(s): 91 - 101
12/08/2008 Authors: Li J; Xing M; Zhu M; Wang X; Wang M; Zhou S; Li N; Wu R; Zhou M
Berberine Induces Apoptosis in Acute Lymphoblastic Leukemia Cells through Downregulation of the MDM2 Oncoprotein
Volume: 112 Page(s): 575 - 575
11/16/2008 Authors: Gu L; Shah N; Zhou M
Transmembrane TNF-alpha mediates "forward" and "reverse" signaling, inducing cell death or survival via the NF-kappaB pathway in Raji Burkitt lymphoma cells.
J Leukoc Biol Volume: 84 Page(s): 789 - 797
09/01/2008 Authors: Zhang H; Yan D; Shi X; Liang H; Pang Y; Qin N; Chen H; Wang J; Yin B; Jiang X
Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells.
Mol Cancer Ther Volume: 7 Page(s): 1101 - 1109
05/01/2008 Authors: Zhu N; Gu L; Li F; Zhou M
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2.
Leukemia Volume: 22 Page(s): 730 - 739
04/01/2008 Authors: Gu L; Zhu N; Findley HW; Zhou M
Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells.
BMC Cancer Volume: 8 Page(s): 69
03/06/2008 Authors: Fang J; Gu L; Zhu N; Tang H; Alvarado CS; Zhou M
Down-regulation of tissue factor by siRNA increased doxorubicin-induced apoptosis in human neuroblastoma.
J Huazhong Univ Sci Technolog Med Sci Volume: 28 Page(s): 42 - 45
02/01/2008 Authors: Fang J; Tang H; Xia L; Zhou M; Chen Y; Wei W; Hu Y; Song S; Hong M
The MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2
Volume: 110 Page(s): 137B - 137B
11/16/2007 Authors: Gu L; Zhu N; Findley HW; Zhou M
Inhibition of Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells
Volume: 110 Page(s): 821A - 821A
11/16/2007 Authors: Zhu N; Gu L; Zhou M
[Inhibition of tissue factor by siRNA enhances doxorubicin-induced apoptosis in human neuroblastoma].
Zhonghua Xue Ye Xue Za Zhi Volume: 28 Page(s): 594 - 597
09/01/2007 Authors: Fang J; Tang H; Xia L-H; Zhou M-X; Chen Y; Wei W-N; Hu Y; Song S-J
Contribution of STAT3 to the activation of survivin by GM-CSF in CD34+ cell lines.
Exp Hematol Volume: 35 Page(s): 957 - 966
06/01/2007 Authors: Gu L; Chiang K-Y; Zhu N; Findley HW; Zhou M
Mechanism of action differences in the antitumor effects of transmembrane and secretory tumor necrosis factor-alpha in vitro and in vivo.
Cancer Immunol Immunother Volume: 55 Page(s): 1470 - 1479
12/01/2006 Authors: Li Q; Li L; Shi W; Jiang X; Xu Y; Gong F; Zhou M; Edwards CK; Li Z
Contribution of STAT3 to activation of survivin by Granulocyte-macrophage colony-stimulating factor in CD34+cells.
Volume: 108 Page(s): 130B - 130B
11/16/2006 Authors: Gu L; Chiang K-Y; Zhu N; Findley HW; Zhou M
Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer.
BMC Cancer Volume: 6 Page(s): 231
09/30/2006 Authors: Zhou S; Wang G-P; Liu C; Zhou M
Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression.
J Biol Chem Volume: 281 Page(s): 25903 - 25914
09/08/2006 Authors: Peng X-H; Karna P; Cao Z; Jiang B-H; Zhou M; Yang L
Inhibition of nuclear factor-kappaB activation is essential for membrane-associated TNF-alpha-induced apoptosis in HL-60 cells.
Immunol Cell Biol Volume: 84 Page(s): 366 - 373
08/01/2006 Authors: Shi W; Li L; Shi X; Zheng F; Zeng J; Jiang X; Gong F; Zhou M; Li Z
KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia.
J Biol Chem Volume: 281 Page(s): 14711 - 14718
05/26/2006 Authors: Zhu N; Gu L; Findley HW; Chen C; Dong J-T; Yang L; Zhou M
Endogenous TNFalpha mediates cell survival and chemotherapy resistance by activating the PI3K/Akt pathway in acute lymphoblastic leukemia cells.
Leukemia Volume: 20 Page(s): 900 - 904
05/01/2006 Authors: Gu L; Findley HW; Zhu N; Zhou M
Endogenous TNF alpha mediates cell survival and chemotherapy resistance by activating the PI3K/Akt pathway in childhood acute lymphoblastic leukemia.
Volume: 106 Page(s): 216B - 216B
11/16/2005 Authors: Gu LB; Findley HW; Zhu NX; Zhou MX
Vitamin K3 selectively induces apoptosis in acute lymphoblastic leukemia cells with constitutive activation of IKK alpha/NF-kappa B activation.
Volume: 106 Page(s): 253A - 253A
11/16/2005 Authors: Zhu NX; Gu LB; Findley HW; Chiang KY; Zhou MX
Expression of inhibitor-of-apoptosis protein (IAP) livin in pediatric acute lymphoblastic leukemia (ALL) cells.
Volume: 106 Page(s): 210B - 210B
11/16/2005 Authors: Dasgupta A; Gu LB; Alvarado CS; Zhou MX; Findley HW
Transcriptional repression of the eukaryotic initiation factor 4E gene by wild type p53.
Biochem Biophys Res Commun Volume: 335 Page(s): 1272 - 1279
10/07/2005 Authors: Zhu N; Gu L; Findley HW; Zhou M
Differential expression of survivin-2B and survivin-DeltaEx3 is inversely associated with disease relapse and patient survival in non-small-cell lung cancer (NSCLC).
Lung Cancer Volume: 49 Page(s): 353 - 361
09/01/2005 Authors: Ling X; Yang J; Tan D; Ramnath N; Younis T; Bundy BN; Slocum HK; Yang L; Zhou M; Li F
Expression of inhibitor-of-apoptosis protein (IAP) livin by neuroblastoma cells: correlation with prognostic factors and outcome.
Pediatr Dev Pathol Volume: 8 Page(s): 621 - 629
01/01/2005 Authors: Kim D-K; Alvarado CS; Abramowsky CR; Gu L; Zhou M; Soe M-M; Sullivan K; George B; Schemankewitz E; Findley HW
Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively.
J Biol Chem Volume: 279 Page(s): 52141 - 52149
12/10/2004 Authors: Gu L; Zhu N; Findley HW; Woods WG; Zhou M
Loss of PTEN expression induces NF-kappa B via PI3K/akt pathway involving resistance to chemotherapy in acute lymphoblastic leukemia cell lines
Volume: 104 Page(s): 192B - 193B
11/16/2004 Authors: Gu LB; Zhu NX; Findley HW; Zhou MX
An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy.
Volume: 104 Page(s): 953A - 953A
11/16/2004 Authors: Zhu NX; Gu LB; Findley HW; Li FZ; Zhou MX
An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy.
Oncogene Volume: 23 Page(s): 7545 - 7551
09/30/2004 Authors: Zhu N; Gu L; Findley HW; Li F; Zhou M
[Regulation of NF-kappaB/P65 by MDM2 in acute lymphoblastic leukemia in childhood].
Zhonghua Er Ke Za Zhi Volume: 41 Page(s): 921 - 924
12/01/2003 Authors: Hu Q; Zhou M-X; Liu S-Y; Zhang L-Q; Liu A-Q; Guo Y-J; Song Y
Transfection of a dominant negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: Interaction of IkBm and p53.
Volume: 102 Page(s): 200B - 200B
11/16/2003 Authors: Gu LB; Findley HW; Zhu NX; Woods WG; Zhou MX
Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53.
Oncogene Volume: 22 Page(s): 8137 - 8144
11/06/2003 Authors: Zhou M; Gu L; Zhu N; Woods WG; Findley HW
PTEN reverses MDM2-mediated chemotherapy resistance by interacting with p53 in acute lymphoblastic leukemia cells.
Cancer Res Volume: 63 Page(s): 6357 - 6362
10/01/2003 Authors: Zhou M; Gu L; Findley HW; Jiang R; Woods WG
BL22, an anti-CD22 recombinant immunotoxin, is active in vitro and in vivo against B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells from pediatric patients.
Volume: 100 Page(s): 764A - 764A
11/16/2002 Authors: Lew G; Gu LB; Zhou MX; Kreitman RJ; FitzGerald DJ; Pastan I; Woods WG; Findley HW
Endogenous TNF-alpha activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway in childhood acute lymphoblastic leukemia.
Volume: 100 Page(s): 762A - 762A
11/16/2002 Authors: Rong J; Gu LB; Findley HW; Woods WG; Zhou MX
DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells.
Volume: 100 Page(s): 743A - 743A
11/16/2002 Authors: Zhou MX; Gu LB; Li FZ; Zhu YR; Woods WG; Findley HW
PTEN Sensitizes MDM2-overexpressing acute lymphoblastic leukemia cells to chemotherapy by inhibiting MDM2 binding to p53
Volume: 100 Page(s): 206B - 206B
11/16/2002 Authors: Zhou MX; Gu LB; Zhu YR; Woods WG; Findley HW
The MDM2-binding peptide PNC-28 is cytotoxic for leukemic cells from pediatric acute leukemia patients.
Volume: 100 Page(s): 545A - 545A
11/16/2002 Authors: Gu LB; Findley HW; Lauer S; Chiang KY; Woods WG; Zhou MX
Cytotoxic effect of an MDM2-binding peptide on MDM2-overexpressing acute lymphoblastic leukemia cell lines.
Volume: 100 Page(s): 194A - 194A
11/16/2002 Authors: Zhou MX; Gu LB; Zhu YR; Rong J; Findley HW; Woods WG
DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells
Volume: 38 Page(s): S163 - S163
11/01/2002 Authors: Zhou M; Gu L; Li F; Zhu Y; Woods W; Findley H
DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells.
J Pharmacol Exp Ther Volume: 303 Page(s): 124 - 131
10/01/2002 Authors: Zhou M; Gu L; Li F; Zhu Y; Woods WG; Findley HW
MDM2 induces NF-kappaB/p65 expression transcriptionally through Sp1-binding sites: a novel, p53-independent role of MDM2 in doxorubicin resistance in acute lymphoblastic leukemia.
Blood Volume: 99 Page(s): 3367 - 3375
05/01/2002 Authors: Gu L; Findley HW; Zhou M
Signaling pathway of apoptosis induced by vincristine in acute lymphoblastic leukemia cells: Activation of caspase-2 and downregulation of NF-kB are required for vincristine-induced apoptosis.
BLOOD Volume: 98 Page(s): 311A - 311A
11/16/2001 Authors: Zhou MX; Gu LB; Findley HW; Woods WG
Distinct effect of p53 mutations on activation of NF-kB/p65 and p65-mediated gene expression in acute lymphoblastic leukemia cell lines.
BLOOD Volume: 98 Page(s): 174B - 174B
11/16/2001 Authors: Zhou MX; Gu LB; Woods WG; Findley HW
MDM2 activates NF-kB/p65 gene transcription through sp1-binding site in acute lymphoblastic leukemia cells: A novel, p53-independent mechanism by which MDM2 confers resistance to chemotherapy.
BLOOD Volume: 98 Page(s): 303A - 303A
11/16/2001 Authors: Gu LB; Findley HW; Woods WG; Zhou MX
Inhibition of constitutive NFkB activation blocks ionizing radiation-mediated MDM2 induction and induces growth suppression and increased apoptosis in an acute lymphoblastic leukemia cell line EU-1.
BLOOD Volume: 96 Page(s): 299A - 299A
11/16/2000 Authors: Zhou MX; Gu LB; Findley HW
Regulation of NFkB/p65 transcription and NFkB/p65-mediated gene expression by MDM2 in childhood acute lymphoblastic leukemia cells.
BLOOD Volume: 96 Page(s): 700A - 700A
11/16/2000 Authors: Gu LB; Findley HW; Zhou MX
CD40 ligand upregulates expression of the IL-3 receptor and stimulates proliferation of B-lineage acute lymphoblastic leukemia cells in the presence of IL-3.
Leukemia Volume: 14 Page(s): 403 - 411
03/01/2000 Authors: Zhou M; Gu L; Holden J; Yeager AM; Findley HW
Incidence and prognostic significance of MDM2 oncoprotein overexpression in relapsed childhood acute lymphoblastic leukemia.
Leukemia Volume: 14 Page(s): 61 - 67
01/01/2000 Authors: Zhou M; Gu L; Abshire TC; Homans A; Billett AL; Yeager AM; Findley HW
CD40 ligand upregulates expression of the IL-3 receptor and stimulates proliferation of B-lineage acute lymphoblastic leukemia cells in the presence of IL-3.
BLOOD Volume: 94 Page(s): 72A - 72A
11/15/1999 Authors: Zhou MX; Gu LB; Holden J; Yeager AM; Findley HW
The proteasome inhibitor LLnL induces apoptosis and sensitizes adriamycin-resistant NFkB plus acute lymphoblastic leukemia cells.
BLOOD Volume: 94 Page(s): 199B - 199B
11/15/1999 Authors: Zhou MX; Gu LB; Yeager AM; Findley HW
The clinical significance of Fas expression in leukemia: questions and controversies.
Leukemia Volume: 13 Page(s): 147 - 149
02/01/1999 Authors: Findley HW; Zhou M
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
BLOOD Volume: 92 Page(s): 80A - 80A
11/15/1998 Authors: Zhou M; Gu L; Yeager AM; Findley HW
Cytotoxicity of an anti-CD19 disulfide-linked variable region (dsFv) recombinant immunotoxin for CD19+ leukemic cells from pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients.
BLOOD Volume: 92 Page(s): 613A - 613A
11/15/1998 Authors: Findley HW; Nambiar M; Zhou M; Gu L; FitzGerald DJ; Yeager AM; Pastan I; Kreitman RJ
Induction of NFkB-p65/RelA protein by MDM2 in childhood acute lymphoblastic leukemia (ALL) cells: A novel mechanism by which MDM2 confers resistance to chemotherapy and poor prognosis.
BLOOD Volume: 92 Page(s): 81A - 81A
11/15/1998 Authors: Zhou M; Gu L; Abshire T; Homans A; Billett AL; Yeager AM; Findley HW
Sensitivity to Fas-mediated apoptosis in pediatric acute lymphoblastic leukemia is associated with a mutant p53 phenotype and absence of Bcl-2 expression.
Leukemia Volume: 12 Page(s): 1756 - 1763
11/01/1998 Authors: Zhou M; Gu L; Yeager AM; Findley HW
Myeloperoxidase gene expression in infant leukemia: a Pediatric Oncology Group Study.
Leuk Lymphoma Volume: 29 Page(s): 145 - 160
03/01/1998 Authors: Alvarado CS; Austin GE; Borowitz MJ; Shuster JJ; Carroll AJ; Austin ED; Zhou M; Zaki SR; Pullen J
Pediatric acute myelogenous leukemia cells express IL-6 receptors and are sensitive to a recombinant IL6-Pseudomonas exotoxin.
Leukemia Volume: 12 Page(s): 182 - 191
02/01/1998 Authors: Boayue KB; Gu L; Yeager AM; Kreitman RJ; Findley HW
Expression of Bcl-2 is associated with inhibition of Fas-induced CPP32 activation and apoptosis in acute lymphoblastic leukemia cells.
BLOOD Volume: 90 Page(s): 306 - 306
11/15/1997 Authors: Zhou M; Gu L; Yeager AM; Findley HW
Elevated MDM2 protein expression in pediatric acute lymphoblastic leukemia (ALL) is associated with in vitro resistance to adriamycin and decreased duration of first remission (CR1).
BLOOD Volume: 90 Page(s): 824 - 824
11/15/1997 Authors: Zhou M; Gu L; Jurickova I; Yarrington AK; Absbire T; Homans A; Yeager AM; Findley HW
Bcl-2 can mediate resistance to LAK but not CTL effectors in human pre-B ALL.
BLOOD Volume: 90 Page(s): 3807 - 3807
11/15/1997 Authors: Boyer MW; Jurickova I; Unangst T; Handoyo S; Gu L; Yeager AM; Zhou M; Findley HW
[Relationship between bcl-X(L) expression and sensitivity to chemotherapy in acute myeloid leukemic cells].
Zhonghua Xue Ye Xue Za Zhi Volume: 18 Page(s): 584 - 587
11/01/1997 Authors: Zhou J; Chen Y; Li C; Wang B; Wang B; Qiao Z; Zhou M; Findley HW; Wang B
Expression of interleukin-6 receptors by pediatric acute lymphoblastic leukemia cells with the t(4;11) translocation: a possible target for therapy with recombinant IL6-Pseudomonas exotoxin.
Leukemia Volume: 11 Page(s): 1779 - 1786
10/01/1997 Authors: Gu L; Zhou M; Jurickova I; Yeager AM; Kreitman RJ; Phillips CN; Findley HW
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia.
Blood Volume: 89 Page(s): 2986 - 2993
04/15/1997 Authors: Findley HW; Gu L; Yeager AM; Zhou M
Incidence and clinical significance of CDKN2/MTS1/P16ink4A and MTS2/P15ink4B gene deletions in childhood acute lymphoblastic leukemia.
Pediatr Hematol Oncol Volume: 14 Page(s): 141 - 150
01/01/1997 Authors: Zhou M; Gu L; Yeager AM; Findley HW
Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis childhood acute lymphoblastic leukemia.
BLOOD Volume: 88 Page(s): 820 - 820
11/15/1996 Authors: Findley HW; Gu L; Yeager AM; Zhou M
Effects of endogenous TNF-alpha on activation of NF kappa B and growth of pediatric acute lymphoblastic leukemia cells.
BLOOD Volume: 88 Page(s): 1485 - 1485
11/15/1996 Authors: Zhou M; Gu L; Yeager AM; Findley HW
Expression and regulation of Bcl-2 and Bcl-xl correlate with P53 status in childhood acute lymphoblastic leukemia.
EXPERIMENTAL HEMATOLOGY Volume: 24 Page(s): 543 - 543
08/01/1996 Authors: Zhou M; Gu L; Yeager AM; Findley HW
Expression of Fas and Bcl-2 by childhood acute lymphoblastic leukemia cells: Involvement of Bcl-2 in Fas-mediated apoptosis.
BLOOD Volume: 86 Page(s): 686 - 686
11/15/1995 Authors: Findley HW; Gu L; Wu J; Yeager AM; Zhou M
Differential regulation of Bcl-2 and Bax gene expression in the response to tumor necrosis factor-alpha (TNF-alpha) and ionizing radiation by TNF+ and TNF- acute lymphoblastic leukemia cell lines
BLOOD Volume: 86 Page(s): 2981 - 2981
11/15/1995 Authors: Zhou M; Gu L; Yeager AM; Findley HW
Expression of interleukin-6 receptors by pediatric acute myeloid leukemia (AML) and myeloid-antigen-positive acute lymphoblastic leukemia (My+ALL) cells: A potential target for therapy
BLOOD Volume: 86 Page(s): 171 - 171
11/15/1995 Authors: Gu L; Boayue KB; Zhou M; Yeager AM; Findley HW
Homozygous deletions of the CDKN2 (MTS1/p16ink4) gene in cell lines established from children with acute lymphoblastic leukemia.
Leukemia Volume: 9 Page(s): 1159 - 1161
07/01/1995 Authors: Zhou M; Gu L; James CD; He J; Yeager AM; Smith SD; Findley HW
Overexpression of the MDM2 gene by childhood acute lymphoblastic leukemia cells expressing the wild-type p53 gene.
Blood Volume: 85 Page(s): 1608 - 1614
03/15/1995 Authors: Zhou M; Yeager AM; Smith SD; Findley HW
Transforming growth factor beta 1 messenger RNA in Reed-Sternberg cells in nodular sclerosing Hodgkin's disease.
J Clin Pathol Volume: 48 Page(s): 160 - 163
02/01/1995 Authors: Newcom SR; Gu L
IDENTIFICATION OF RB MUTATIONS AND P53 MUTATIONS IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA CELL-LINES
BLOOD Volume: 84 Page(s): A46 - A46
11/15/1994 Authors: ZHOU M; YEAGER AM; GU L; FINDLEY HW
CLINICAL IMPORTANCE OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA (ALL)
BLOOD Volume: 84 Page(s): A148 - A148
11/15/1994 Authors: ZHOU M; GU L; YEAGER AM; FINDLEY HW
ABNORMALITIES OF P53 TUMOR-SUPPRESSOR GENE AND MDM2 ONCOGENE IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA
EXPERIMENTAL HEMATOLOGY Volume: 22 Page(s): 751 - 751
08/01/1994 Authors: ZHOU M; FINDLEY HW; SMITH SD; YEAGER AM
EXPRESSION OF INTERLEUKIN-6 AND INTERLEUKIN-6 RECEPTORS IN PEDIATRIC ACUTE LYMPHOBLASTIC-LEUKEMIA - PATHOPHYSIOLOGIC AND THERAPEUTIC IMPLICATIONS
EXPERIMENTAL HEMATOLOGY Volume: 22 Page(s): 729 - 729
08/01/1994 Authors: ZHOU M; MA L; RIZACK T; YEAGER AM; FINDLEY HW
Characterization of a myeloperoxidase mRNA(+) acute lymphoblastic leukemia cell line (EU-1/ALL) established from a child with an apparent case of ALL.
Leukemia Volume: 8 Page(s): 659 - 663
04/01/1994 Authors: Zhou M; Zaki SR; Ragab AH; Findley HW
ROLE OF ENDOGENOUS IL6 IN THE PROLIFERATION OF LEUKEMIC-CELLS IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA
BLOOD Volume: 82 Page(s): A551 - A551
11/15/1993 Authors: ZHOU M; FINDLEY HW
ABNORMALITIES OF P53 TUMOR-SUPPRESSOR GENE AND IL6 EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA
BLOOD Volume: 82 Page(s): A52 - A52
11/15/1993 Authors: ZHOU M; MA L; FINDLEY HW
Expression of myeloperoxidase mRNA by leukemic cells from childhood acute lymphoblastic leukemia.
Leukemia Volume: 7 Page(s): 1180 - 1183
08/01/1993 Authors: Zhou M; Findley HW; Zaki SR; Little F; Coffield LM; Ragab AH
The effect of recombinant GM-CSF and G-CSF on the bone marrow cells of children with acute lymphoblastic leukemia.
Leukemia Volume: 6 Page(s): 1210 - 1212
11/01/1992 Authors: Ode DL; Zhou M; Findley HW; Abdel-Mageed A; Ragab AH
Interleukin-4 is an autocrine growth factor secreted by the L-428 Reed-Sternberg cell.
Blood Volume: 79 Page(s): 191 - 197
01/01/1992 Authors: Newcom SR; Ansari AA; Gu L
CHARACTERIZATION OF AN ACUTE MIXED-LINEAGE LEUKEMIC-CELL LINE ESTABLISHED FROM A CHILD WITH ACUTE LYMPHOBLASTIC-LEUKEMIA
EXPERIMENTAL HEMATOLOGY Volume: 19 Page(s): 535 - 535
07/01/1991 Authors: ZHOU M; ZAKI SR; FINDLEY HW; COFFIELD LM; GU L; RAGAB AH
A B-CELL PRECURSOR-ACUTE LYMPHOBLASTIC-LEUKEMIA (BCP-ALL) CELL-LINE PRODUCES AUTOCRINE GROWTH FACTOR(S) WHICH CAN STIMULATE PROLIFERATION OF LEUKEMIC-CELLS FROM CHILDREN WITH BCP-ALL
EXPERIMENTAL HEMATOLOGY Volume: 19 Page(s): 534 - 534
07/01/1991 Authors: FINDLEY HW; HILL T; ZHOU M; LITTLE F; AMBRUS J; RAGAB AH
Influence of cytokines and immunosuppressive drugs on major histocompatibility complex class I/II expression by human cardiac myocytes in vitro.
Hum Immunol Volume: 31 Page(s): 123 - 133
06/01/1991 Authors: Wang YC; Herskowitz A; Gu LB; Kanter K; Lattouf O; Sell KW; Ahmed-Ansari A
Effect of tumor necrosis factor-alpha on the proliferation of leukemic cells from children with B-cell precursor-acute lymphoblastic leukemia (BCP-ALL): studies of primary leukemic cells and BCP-ALL cell lines.
Blood Volume: 77 Page(s): 2002 - 2007
05/01/1991 Authors: Zhou MX; Findley HW; Ma LH; Zaki SR; Hill T; Hamid M; Hooper WC; Ragab AH
THE INHIBITION OF NORMAL CFU-GM PROGENITORS BY CONDITIONED MEDIA (CM) FROM LEUKEMIC-CELL LINES ESTABLISHED FROM CHILDREN WITH ACUTE LYMPHOBLASTIC-LEUKEMIA
PEDIATRIC RESEARCH Volume: 27 Page(s): A153 - A153
04/01/1990 Authors: ZHOU M; FINDLEY HW; RAGAB AH
Effects of low molecular weight B-cell growth factor on proliferation of leukemic cells from children with B-cell precursor-acute lymphoblastic leukemia.
Blood Volume: 75 Page(s): 951 - 957
02/15/1990 Authors: Findley HW; Zhou MX; Davis R; Abdul-Rahim Y; Hnath R; Ragab AH
Assay of lymphokine-activated killer activity generated from bone marrow cells of children with acute lymphoblastic leukemia.
Blood Volume: 75 Page(s): 160 - 165
01/01/1990 Authors: Zhou MX; Findley HW; Davis R; Ragab AH
Low molecular weight B-cell growth factor and recombinant interleukin-2 are together able to generate cytotoxic T lymphocytes with LAK activity from the bone marrow cells of children with acute lymphoblastic leukemia.
Blood Volume: 74 Page(s): 1355 - 1359
09/01/1989 Authors: Zhou MX; Findley HW; Ragab AH

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Muxiang Zhou MD

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