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Profile

Meng Zhang

  • Department of Urology
    Assistant Professor
  • Emory University School of Medicine
    Urology
    Health Science Research Building 1, 1760 Haygood Dr NE Room E369
Head shot of Meng Zhang

Overview

Dr. Meng Zhang received her PhD in Cell Biology from Yale University and her MS in Computer Science from Stanford University. She finished her postdoctoral training at the University of California, San Francisco, and has a strong and unique multi-disciplinary research background across both molecular and computational biology. Dr. Zhang has published first- and co-author papers in high-profile journals including Nature Cell Biology, Genes & Development, Nature Genetics, Nature Communications, Cancer Research, etc. Her research focuses on RNA biology in development and cancer and aims to identify regulatory mechanisms and novel RNA and protein species with translational potential.

At Emory, Dr. Zhang’s lab studies the alterations of RNA transcription, processing, and translation in tumor cells, with the long-term goal to understand the biology of cancer progression and therapy resistance, and to identify novel therapeutic targets to overcome resistance. Her lab integrates a variety of research approaches, including clinical genomics, CRISPR-based functional genomics, and molecular biology to systematically investigate RNA biology in cancer progression and resistance, leading to discoveries that will benefit patients.

Academic Appointment

  • Assistant Professor, Emory University School of Medicine

Education

Degrees

  • MS from Stanford University
  • PhD from Yale University

Research

Publications

  • Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity.
    Nat Commun Volume: 16 Page(s): 5616
    07/01/2025 Authors: Liu T; Zhang M; Farsh T; Li H; Kishishita A; Barpanda A; Leung SG; Zhu J; Jung H; Hua JT
  • Comparative characterization of human accelerated regions in neurons.
    Nature Volume: 640 Page(s): 991 - 999
    04/01/2025 Authors: Cui X; Yang H; Cai C; Beaman C; Yang X; Liu H; Ren X; Amador Z; Jones IR; Keough KC
  • Synthetic Lethal Targeting of CDK12-Deficient Prostate Cancer with PARP Inhibitors.
    Clin Cancer Res Volume: 30 Page(s): 5445 - 5458
    12/02/2024 Authors: Chou J; Robinson TM; Egusa EA; Lodha R; Zhang M; Badura M; Mikayelyan M; Delavan HM; Swinderman J; Wilson C
  • Transcription and DNA replication collisions lead to large tandem duplications and expose targetable therapeutic vulnerabilities in cancer.
    Nat Cancer Volume: 5 Page(s): 1885 - 1901
    12/01/2024 Authors: Yang Y; Badura ML; O'Leary PC; Delavan HM; Robinson TM; Egusa EA; Zhong X; Swinderman JT; Li H; Zhang M
  • An Atlas of Accessible Chromatin in Advanced Prostate Cancer Reveals the Epigenetic Evolution during Tumor Progression.
    Cancer Res Volume: 84 Page(s): 3086 - 3100
    09/16/2024 Authors: Shrestha R; Chesner LN; Zhang M; Zhou S; Foye A; Lundberg A; Weinstein AS; Sjöström M; Zhu X; Moreno-Rodriguez T
  • Genomic and transcriptomic features of androgen receptor signaling inhibitor resistance in metastatic castration-resistant prostate cancer.
    J Clin Invest Volume: 134
    08/13/2024 Authors: Zhu X; Farsh T; Vis D; Yu I; Li H; Liu T; Sjöström M; Shrestha R; Kneppers J; Severson T
  • Integrated analyses highlight interactions between the three-dimensional genome and DNA, RNA and epigenomic alterations in metastatic prostate cancer.
    Nat Genet Volume: 56 Page(s): 1689 - 1700
    08/01/2024 Authors: Zhao SG; Bootsma M; Zhou S; Shrestha R; Moreno-Rodriguez T; Lundberg A; Pan C; Arlidge C; Hawley JR; Foye A
  • Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression.
    Nat Cell Biol Volume: 26 Page(s): 1176 - 1186
    07/01/2024 Authors: Zhang M; Sjöström M; Cui X; Foye A; Farh K; Shrestha R; Lundberg A; Dang HX; Li H; Febbo PG
  • Single cell-transcriptomic analysis informs the lncRNA landscape in metastatic castration resistant prostate cancer.
    NPJ Genom Med Volume: 9 Page(s): 14
    02/23/2024 Authors: Saha D; Dang HX; Zhang M; Quigley DA; Feng FY; Maher CA
  • The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer.
    Cancer Res Volume: 83 Page(s): 2763 - 2774
    08/15/2023 Authors: Lundberg A; Zhang M; Aggarwal R; Li H; Zhang L; Foye A; Sjöström M; Chou J; Chang K; Moreno-Rodriguez T
  • Intrinsic Molecular Subtypes of Metastatic Castration-Resistant Prostate Cancer.
    Clin Cancer Res Volume: 28 Page(s): 5396 - 5404
    12/15/2022 Authors: Feng E; Rydzewski NR; Zhang M; Lundberg A; Bootsma M; Helzer KT; Lang JM; Aggarwal R; Small EJ; Quigley DA
  • The 5-Hydroxymethylcytosine Landscape of Prostate Cancer.
    Cancer Res Volume: 82 Page(s): 3888 - 3902
    11/02/2022 Authors: Sjöström M; Zhao SG; Levy S; Zhang M; Ning Y; Shrestha R; Lundberg A; Herberts C; Foye A; Aggarwal R
  • Why ARNT Prostate Tumors Responding to Enzalutamide?
    Cancer Discov Volume: 12 Page(s): 2017 - 2019
    09/02/2022 Authors: Zhang M; Moreno-Rodriguez T; Quigley DA
  • Predicting cancer drug TARGETS - TreAtment Response Generalized Elastic-neT Signatures.
    NPJ Genom Med Volume: 6 Page(s): 76
    09/21/2021 Authors: Rydzewski NR; Peterson E; Lang JM; Yu M; Laura Chang S; Sjöström M; Bakhtiar H; Song G; Helzer KT; Bootsma ML
  • Autoantibody Landscape in Patients with Advanced Prostate Cancer.
    Clin Cancer Res Volume: 26 Page(s): 6204 - 6214
    12/01/2020 Authors: Chen WS; Haynes WA; Waitz R; Kamath K; Vega-Crespo A; Shrestha R; Zhang M; Foye A; Baselga Carretero I; Perez Garcilazo I
  • The DNA methylation landscape of advanced prostate cancer.
    Nat Genet Volume: 52 Page(s): 778 - 789
    08/01/2020 Authors: Zhao SG; Chen WS; Li H; Foye A; Zhang M; Sjöström M; Aggarwal R; Playdle D; Liao A; Alumkal JJ
  • Post-transcriptional regulation of mouse neurogenesis by Pumilio proteins.
    Genes Dev Volume: 31 Page(s): 1354 - 1369
    07/01/2017 Authors: Zhang M; Chen D; Xia J; Han W; Cui X; Neuenkirchen N; Hermes G; Sestan N; Lin H
  • Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction.
    Blood Volume: 128 Page(s): 923 - 933
    08/18/2016 Authors: Sanada C; Xavier-Ferrucio J; Lu Y-C; Min E; Zhang P-X; Zou S; Kang E; Zhang M; Zerafati G; Gallagher PG
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