Manuel Yepes MD
Academic Appointment
- Professor (tenure), Neurology, Emory University
- Distinguished O. Wayne Rollins Endowed Chair for Stroke and Neuroimaging, Emory /Yerkes National Primate Research Center, Emory University
- Professor of Neuroscience; Neuropharmacology and Neurologic Diseases Section, Emory/Yerkes National Primate Research Center, Emory University
Education
Degrees
- MD from Javeriana University, Bogota, Colombia
- General Neurology from Georgetown University
- Vascular Neurology from Georgetown University
Research
Focus
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Neurorepair
We study the role of the plasminogen activating system in the central nervous system. Our research focuses on the molecular pathways that neurons use to repair their synapses after an ischemic stroke or exposure to amyloid . We also study the mechanisms that regulate the permeability of the blood-brain barrier in the ischemic brain. Our goal is to develop therapeutic strategies to protect the synapses of patients with ischemic stroke and Alzheimers disease, and to prevent the development of cerebral edema following an acute ischemic injury.
Publications
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Plasminogen activator inhibitor-1 mediates cerebral ischemia-induced astrocytic reactivity.
J Cereb Blood Flow Metab Volume: 45 Page(s): 102 - 114
01/01/2025 Authors: Yanev P; Martin-Jimenez C; Vesga-Jimenez DJ; Zvinys L; Weinrich N; Cree MA; Preuss TM; Zhang X; Yepes M -
Reprint of: Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain.
Neuroscience Volume: 550 Page(s): 21 - 29
07/09/2024 Authors: Yepes M -
Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain.
Neuroscience Volume: 542 Page(s): 69 - 80
03/26/2024 Authors: Yepes M -
Simulation-based education in neurology: lessons from the COVID-19 pandemic.
BMC Res Notes Volume: 16 Page(s): 307
11/02/2023 Authors: Toro J; Rivera JS; Gaitn J; Rodrguez D; Serna-Corredor LA; Corts-Muoz F; Medina T; Yepes M -
Tissue-type plasminogen activator induces TNF--mediated preconditioning of the blood-brain barrier.
J Cereb Blood Flow Metab Volume: 42 Page(s): 667 - 682
04/01/2022 Authors: Diaz A; Woo Y; Martin-Jimenez C; Merino P; Torre E; Yepes M -
Neurological Complications of SARS-CoV-2 Infection and COVID-19 Vaccines: From Molecular Mechanisms to Clinical Manifestations.
Curr Drug Targets Volume: 23 Page(s): 1620 - 1638
01/01/2022 Authors: Yepes M -
Urokinase-Type Plasminogen Activator Triggers Wingless/Int1-Independent Phosphorylation of the Low-Density Lipoprotein Receptor-Related Protein-6 in Cerebral Cortical Neurons.
J Alzheimers Dis Volume: 89 Page(s): 877 - 891
01/01/2022 Authors: Diaz A; Martin-Jimenez C; Woo Y; Merino P; Torre E; Yepes M -
Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain.
J Cereb Blood Flow Metab Volume: 41 Page(s): 2381 - 2394
09/01/2021 Authors: Diaz A; Merino P; McCann P; Yepes MA; Quiceno LG; Torre E; Tomkins A; Zhang X; Hales CM; Tong FC -
Urokinase-type plasminogen activator-mediated crosstalk between N-cadherin and -catenin promotes wound healing.
J Cell Sci Volume: 134
06/01/2021 Authors: Diaz A; Martin-Jimenez C; Xu Y; Merino P; Woo Y; Torre E; Yepes M -
Plasminogen Activators in Neurovascular and Neurodegenerative Disorders.
Int J Mol Sci Volume: 22
04/22/2021 Authors: Yepes M; Woo Y; Martin-Jimenez C