Mark McDonald
Overview
Mark McDonald, MD, is a board certified radiation oncologist specializing in the treatment of head and neck, gastrointestinal and lung cancers, skull base tumors, and tumors of the brain and spine. He has extensive experience with proton therapy and serves as the Medical Director of the Emory Proton Therapy Center.
Dr. McDonald completed his medical school education at The Ohio State University and his residency training at Emory University School of Medicine, where he served as chief resident. In 2009, he was recruited to Indiana University and worked at the Indiana University Health Proton Therapy Center, providing proton therapy primarily to patients with skull base, head and neck, and brain tumors. He returned to Emory to join the Department of Radiation Oncology in September 2015.
Dr. McDonald is a past recipient of the Young Oncologist Essay Award from the American Radium Society, and the Roentgen Resident/Fellow Research Award from the Radiological Society of North America. His research has been recognized in the clinical practice guidelines of the National Comprehensive Cancer Network, and the Database of Abstracts of Reviews of Effects, a repository of quality systematic reviews that evaluate the effects of healthcare interventions.
Dr. McDonalds clinical research focuses on the use of advanced radiation technologies with a special interest in patient outcomes and side effects of treatment. In his past role at Indiana University, he developed and served as principal investigator for a prospective registry for proton therapy clinical outcomes and long-term follow-up. This protocol created a framework to ensure continuity of follow-up and quality outcomes data for patients, and expanded the use of proton therapy to patients with a wider array of diagnoses.
Dr. McDonald has authored and coauthored over 40 research publications and other peer-reviewed articles. He has presented numerous abstracts and served as a faculty member at many national and international scientific meetings. He is frequently invited to be a speaker on proton therapy.
Academic Appointment
- Professor, Department of Radiation Oncology, Emory University School of Medicine
Education
Degrees
- MD from Ohio State University, Columbus
- BA from Xavier University, Cincinnati
Research
Publications
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Neoadjuvant Chemotherapy and Surgery versus Surgery for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma: ECOG-ACRIN EA3163.
Clin Cancer Res Volume: 31 Page(s): 2339 - 2346
06/13/2025 Authors: Saba NF; Flamand Y; Lin DT; Chung CH; McDonald MW; Flampouri S; Khan SA; Snyderman CH; Hanna EY; El-Sayed IH -
Early-phase trial of IAP antagonist tolinapant and definitive radiation in cisplatin-ineligible patients with advanced head and neck cancer.
Clin Cancer Res
05/12/2025 Authors: Schmitt NC; Stokes WA; Bates JE; Kinney BLC; Remick J; McDonald MW; Rudra S; Steininger M; Oyewole M; Patel MR -
Proton Therapy for Spinal Tumors: A Consensus Statement From the Particle Therapy Cooperative Group.
Int J Radiat Oncol Biol Phys Volume: 120 Page(s): 1135 - 1148
11/15/2024 Authors: Chhabra AM; Snider JW; Kole AJ; Stock M; Holtzman AL; Press R; Wang CJ; Li H; Lin H; Shi C -
Institution-level Patterns of Care for Early-stage Oropharynx Cancers in the United States.
Am J Clin Oncol Volume: 47 Page(s): 542 - 548
11/01/2024 Authors: Janopaul-Naylor JR; Liu Y; Cao Y; Schlafstein AJ; Steuer C; Patel MR; Bates JE; McDonald MW; Stokes WA -
Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis.
Clin Cancer Res Volume: 30 Page(s): 4601 - 4608
10/15/2024 Authors: Saba NF; Chaudhary R; Kirtane K; Marra A; Ekpenyong A; McCook-Veal A; Schmitt NC; Gross JH; Patel MR; Remick J -
Olfaction Preservation and Long-Term Outcomes in Patients with Unilateral Endoscopic Resection of Olfactory Neuroblastoma: A Systematic Review and Institutional Experience.
World Neurosurg Volume: 190 Page(s): e874 - e882
10/01/2024 Authors: Rodas A; Tariciotti L; Zohdy YM; Soriano RM; Daoud GE; Porto E; Vuncannon JR; Revuelta-Barbero JM; Garzon-Muvdi T; McDonald M -
Secondary Cancer in Prostate Cancer Patients Treated With Advanced External Beam Radiation Therapy.
Int J Part Ther Volume: 13 Page(s): 100627
09/01/2024 Authors: Kulkarni SE; Patel SA; Sun Y; Jani AB; Gillespie TW; McDonald MW; Liu Y -
Diffeomorphic transformer-based abdomen MRI-CT deformable image registration.
Med Phys Volume: 51 Page(s): 6176 - 6184
09/01/2024 Authors: Lei Y; Matkovic LA; Roper J; Wang T; Zhou J; Ghavidel B; McDonald M; Patel P; Yang X -
Assessing survival outcomes of patients with oral tongue squamous cell carcinoma: Focus on age, sex, and stage.
Head Neck Volume: 46 Page(s): 2167 - 2177
09/01/2024 Authors: Pamulapati S; Abousaud M; Li Y; Ekpenyong A; Rudra S; Remick JS; Bates JE; Stokes WA; McDonald MW; Schmitt NC -
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial.
Nat Med Volume: 30 Page(s): 2373
08/01/2024 Authors: Saba NF; Steuer CE; Ekpenyong A; McCook-Veal A; Magliocca K; Patel M; Schmitt NC; Stokes W; Bates JE; Rudra S