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Profile

Mamoru Shoji MD

  • Department of Hematology and Medical Oncology
    Associate Professor, Emeritus
  • (404) 727-3457
  • mshoji@emory.edu
Head shot of Mamoru Shoji

Education

Degrees

  • MD from Hokkaido University School of Medicine
  • No Degree from Pre-Medical School, Hokkaido University

Research

Focus

  • Pre-clinical development of a novel synthetic curcumin analog and taxol for therapy of tumor angiogenesis and bone metastasis of breast cancer. Develop methods for the targeted delivery of our novel synthetic curcumin analogs (anti-cancer and anti-angiogenesis agent) and taxol to only cancer cells and tumor-associated vascular endothelial cells that feed tumors for treatment of metastatic breast cancer, glioblastoma multiforme, metastatic melanoma, pancreatic cancer and drug resistant head/neck cancer.

Publications

  • Curcumin analogs: Their roles in pancreatic cancer growth and metastasis.
    Int J Cancer Volume: 145 Page(s): 10 - 19
    07/01/2019 Authors: Nagaraju GP; Benton L; Bethi SR; Shoji M; El-Rayes BF
  • Inhibition of breast cancer metastasis to the lungs with UBS109.
    Oncotarget Volume: 9 Page(s): 36102 - 36109
    11/16/2018 Authors: Shoji M; Qian WP; Nagaraju GP; Brat DJ; Pessolano D; Luzietti R; Chennamadhavuni S; Yamaguchi M; Yang L; Liotta DC
  • Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro.
    Mol Cell Biochem Volume: 430 Page(s): 37 - 46
    06/01/2017 Authors: Yamaguchi M; Osuka S; Shoji M; Weitzmann MN; Murata T
  • Novel synthetic curcumin analogs as potent antiangiogenic agents in colorectal cancer.
    Mol Carcinog Volume: 56 Page(s): 288 - 299
    01/01/2017 Authors: Rajitha B; Nagaraju GP; Shaib WL; Alese OB; Snyder JP; Shoji M; Pattnaik S; Alam A; El-Rayes BF
  • Prolonged survival in hepatocarcinoma patients with increased regucalcin gene expression: HepG2 cell proliferation is suppressed by overexpression of regucalcin in vitro.
    Int J Oncol Volume: 49 Page(s): 1686 - 1694
    10/01/2016 Authors: Yamaguchi M; Osuka S; Weitzmann MN; El-Rayes BF; Shoji M; Murata T
  • Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro.
    Int J Oncol Volume: 49 Page(s): 812 - 822
    08/01/2016 Authors: Yamaguchi M; Osuka S; Weitzmann MN; Shoji M; Murata T
  • Tolfenamic acid and curcumin treatment induces pancreatic cancer cell growth inhibition via suppressing Sp1 expression, NF-kB translocation to nucleus
    Volume: 76
    07/01/2016 Authors: Basha RM; Connelly SF; Purnachandra G; Sankpal UT; Patel H; Vishwanatha JK; Shelake S; Tabor-Simeckal L; Shoji M; Simecka JSW
  • Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.
    Int J Oncol Volume: 48 Page(s): 1955 - 1964
    05/01/2016 Authors: Yamaguchi M; Osuka S; Weitzmann MN; El-Rayes BF; Shoji M; Murata T
  • Small molecule tolfenamic acid and dietary spice curcumin treatment enhances antiproliferative effect in pancreatic cancer cells via suppressing Sp1, disrupting NF-kB translocation to nucleus and cell cycle phase distribution.
    J Nutr Biochem Volume: 31 Page(s): 77 - 87
    05/01/2016 Authors: Basha R; Connelly SF; Sankpal UT; Nagaraju GP; Patel H; Vishwanatha JK; Shelake S; Tabor-Simecka L; Shoji M; Simecka JW
  • Inhibition of NF-B translocation by curcumin analogs induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer.
    Cancer Lett Volume: 373 Page(s): 227 - 233
    04/10/2016 Authors: Rajitha B; Belalcazar A; Nagaraju GP; Shaib WL; Snyder JP; Shoji M; Pattnaik S; Alam A; El-Rayes BF
  • Combination of tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species.
    Oncotarget Volume: 7 Page(s): 3186 - 3200
    01/01/2016 Authors: Sankpal UT; Nagaraju GP; Gottipolu SR; Hurtado M; Jordan CG; Simecka JW; Shoji M; El-Rayes B; Basha R
  • The flavonoid p-hydroxycinnamic acid exhibits anticancer effects in human pancreatic cancer MIA PaCa-2 cells in vitro: Comparison with gemcitabine.
    Oncol Rep Volume: 34 Page(s): 3304 - 3310
    12/01/2015 Authors: Yamaguchi M; Murata T; El-Rayes BF; Shoji M
  • The flavonoid p-hydroxycinnamic acid mediates anticancer effects on MDA-MB-231 human breast cancer cells in vitro: Implications for suppression of bone metastases.
    Int J Oncol Volume: 47 Page(s): 1563 - 1571
    10/01/2015 Authors: Yamaguchi M; Murata T; Shoji M; Weitzmann MN
  • Combination of anti-cancer small molecule tolfenamic acid and curcumin effectively inhibits colon cancer cell growth
    Volume: 75
    08/01/2015 Authors: Sankpal UT; Nagaraju GP; Hurtado M; Gottipolu SR; El-Rayes B; Shoji M; Jordan CG; Basha R
  • Targeting NF-kappa B by the curcumin and its analogs EF-31 and UBS-109 decreases growth and angiogenesis of colon cancer
    Volume: 75
    08/01/2015 Authors: Nagaraju GP; Shoji M; El Rayes B
  • Inhibition of NF-kappa B translocation induces G0/G1 arrest and downregulates thymidylate synthase in colorectal cancer
    Volume: 75
    08/01/2015 Authors: Nagaraju GP; Olatunji A; Gupta S; Shoji M; El-Rayes BF
  • Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody.
    J Drug Target Volume: 23 Page(s): 257 - 265
    04/01/2015 Authors: Zhu S; Kisiel W; Lu YJ; Petersen LC; Ndungu JM; Moore TW; Parker ET; Sun A; Sarkaria JN; Snyder JP
  • Curcumin analog UBS109 prevents bone marrow osteoblastogenesis and osteoclastogenesis disordered by coculture with breast cancer MDA-MB-231 bone metastatic cells in vitro.
    Mol Cell Biochem Volume: 401 Page(s): 1 - 10
    03/01/2015 Authors: Yamaguchi M; Zhu S; Weitzmann MN; Snyder JP; Shoji M
  • Antiangiogenic effects of a novel synthetic curcumin analogue in pancreatic cancer.
    Cancer Lett Volume: 357 Page(s): 557 - 565
    02/28/2015 Authors: Nagaraju GP; Zhu S; Ko JE; Ashritha N; Kandimalla R; Snyder JP; Shoji M; El-Rayes BF
  • Combination of anti-cancer small molecule tolfenamic acid and curcumin or curcumin analog EF31 effectively inhibits pancreatic cancer cell growth
    Volume: 74
    10/01/2014 Authors: Basha R; Connelly SF; Nagaraju GP; Sankpal UT; Shoji M; Kayaleh O; El-Rayes B
  • Curcumin analogue UBS109 prevents bone loss in breast cancer bone metastasis mouse model: involvement in osteoblastogenesis and osteoclastogenesis.
    Cell Tissue Res Volume: 357 Page(s): 245 - 252
    07/01/2014 Authors: Yamaguchi M; Zhu S; Zhang S; Wu D; Moore TM; Snyder JP; Shoji M
  • Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993).
    Cancer Chemother Pharmacol Volume: 73 Page(s): 1137 - 1146
    06/01/2014 Authors: Reid JM; Buhrow SA; Gilbert JA; Jia L; Shoji M; Snyder JP; Ames MM
  • Liver S9 Fraction-Derived Metabolites of Curcumin Analogue UBS109.
    ACS Med Chem Lett Volume: 5 Page(s): 288 - 292
    04/10/2014 Authors: Moore TW; Zhu S; Randolph R; Shoji M; Snyder JP
  • Tumor angiogenesis therapy using targeted delivery of Paclitaxel to the vasculature of breast cancer metastases.
    J Drug Deliv Volume: 2014 Page(s): 865732
    01/01/2014 Authors: Zhu S; Kisiel W; Lu YJ; Petersen LC; Ndungu JM; Moore TW; Parker ET; Sun A; Liotta DC; El-Rayes BF
  • Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts.
    Curr Cancer Drug Targets Volume: 14 Page(s): 380 - 393
    01/01/2014 Authors: Zhu S; Moore TW; Morii N; Howard RB; Culver D; Arrendale RF; Reddy P; Evers TJ; Zhang H; Sica G
  • Bioactive flavonoid p-hydroxycinnamic acid stimulates osteoblastogenesis and suppresses adipogenesis in bone marrow culture.
    Cell Tissue Res Volume: 354 Page(s): 743 - 750
    12/01/2013 Authors: Yamaguchi M; Baile CA; Zhu S; Shoji M
  • Anti-angiogenic effects of curcumin and its novel analogs EF-31 and UBS-109 in colorectal cancer
    Volume: 27
    04/01/2013 Authors: Ganji PN; Zhu S; Ko JE; Shoji M; El-Rayes B
  • Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis: involvement in Smad activation and NF-B inhibition.
    Integr Biol (Camb) Volume: 4 Page(s): 905 - 913
    08/01/2012 Authors: Yamaguchi M; Moore TW; Sun A; Snyder JP; Shoji M
  • Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts.
    Integr Biol (Camb) Volume: 4 Page(s): 633 - 640
    06/01/2012 Authors: Zhu S; Moore TW; Lin X; Morii N; Mancini A; Howard RB; Culver D; Arrendale RF; Reddy P; Evers TJ
  • Potent curcumin analogues inhibit pancreatic cancer cell growth and angiogenesis
    CANCER RESEARCH Volume: 72
    04/15/2012 Authors: Nagaraju GP; Zhu S; Diaz R; Shoji M; El-Rayes BF
  • Targeted delivery of paclitaxel to tumor cells: synthesis and in vitro evaluation.
    J Med Chem Volume: 53 Page(s): 3127 - 3132
    04/22/2010 Authors: Ndungu JM; Lu YJ; Zhu S; Yang C; Wang X; Chen G; Shin DM; Snyder JP; Shoji M; Sun A
  • Curcumin analog cytotoxicity against breast cancer cells: exploitation of a redox-dependent mechanism.
    Bioorg Med Chem Lett Volume: 19 Page(s): 6627 - 6631
    12/01/2009 Authors: Sun A; Lu YJ; Hu H; Shoji M; Liotta DC; Snyder JP
  • Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.
    Mol Pharmacol Volume: 74 Page(s): 654 - 661
    09/01/2008 Authors: Kasinski AL; Du Y; Thomas SL; Zhao J; Sun S-Y; Khuri FR; Wang C-Y; Shoji M; Sun A; Snyder JP
  • Targeting tissue factor-expressing tumor angiogenesis and tumors with EF24 conjugated to factor VIIa.
    J Drug Target Volume: 16 Page(s): 185 - 197
    04/01/2008 Authors: Shoji M; Sun A; Kisiel W; Lu YJ; Shim H; McCarey BE; Nichols C; Parker ET; Pohl J; Mosley CA
  • Curcumin analogs-glutathione interactions and proposed redox-dependent mechanism of the anti-cancer effect of the novel analogs
    ACTA PHARMACOLOGICA SINICA Volume: 27 Page(s): 72 - 72
    07/01/2006 Authors: Sun A; Lu YJ; Shoji M; Liotta DC; Snyder JP
  • Synthesis of EF24-tripeptide chloromethyl ketone: a novel curcumin-related anticancer drug delivery system.
    J Med Chem Volume: 49 Page(s): 3153 - 3158
    06/01/2006 Authors: Sun A; Shoji M; Lu YJ; Liotta DC; Snyder JP
  • EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism.
    Anticancer Drugs Volume: 16 Page(s): 263 - 275
    03/01/2005 Authors: Adams BK; Cai J; Armstrong J; Herold M; Lu YJ; Sun A; Snyder JP; Liotta DC; Jones DP; Shoji M
  • Effects of all-trans retinoic acid or chemotherapy on the molecular regulation of systemic blood coagulation and fibrinolysis in patients with acute promyelocytic leukemia.
    J Thromb Haemost Volume: 2 Page(s): 1341 - 1350
    08/01/2004 Authors: Tallman MS; Lefbvre P; Baine RM; Shoji M; Cohen I; Green D; Kwaan HC; Paietta E; Rickles FR
  • Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents.
    Bioorg Med Chem Volume: 12 Page(s): 3871 - 3883
    07/15/2004 Authors: Adams BK; Ferstl EM; Davis MC; Herold M; Kurtkaya S; Camalier RF; Hollingshead MG; Kaur G; Sausville EA; Rickles FR
  • Synthesis and biological evaluation of novel curcumin analogs as anti-tumor agents.
    Volume: 225 Page(s): U190 - U190
    03/01/2003 Authors: Herold M; Ferstl EM; Sun AM; Liotta DC; Snyder JP; Adams B; Shoji M
  • Mitogen-actived protein kinase activation is an early event in melanoma progression.
    Clin Cancer Res Volume: 8 Page(s): 3728 - 3733
    12/01/2002 Authors: Cohen C; Zavala-Pompa A; Sequeira JH; Shoji M; Sexton DG; Cotsonis G; Cerimele F; Govindarajan B; Macaron N; Arbiser JL
  • Novel curcumin analogs as supressors of tumor growth and angiogenesis.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 224 Page(s): U173 - U173
    08/18/2002 Authors: Sun AM; Liotta DC; Snyder JP; Shoji M; Adams B
  • Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues.
    J Am Chem Soc Volume: 123 Page(s): 9313 - 9323
    09/26/2001 Authors: Nicolaou KC; Namoto K; Ritzn A; Ulven T; Shoji M; Li J; D'Amico G; Liotta D; French CT; Wartmann M
  • The role of the hemostatic system in tumor growth, metastasis, and angiogenesis: tissue factor is a bifunctional molecule capable of inducing both fibrin deposition and angiogenesis in cancer.
    Int J Hematol Volume: 73 Page(s): 145 - 150
    02/01/2001 Authors: Rickles FR; Shoji M; Abe K
  • cDNAs encoding the baboon thrombin receptor indicate a primate transcription start site upstream of putative sites reported for the human gene.
    Thromb Res Volume: 98 Page(s): 195 - 201
    04/15/2000 Authors: Hayzer DJ; Shoji M; Hanson SR
  • Inhibition of tissue factor-mediated VEGF production and tumor cell growth by synthetic curcumin analogs.
    BLOOD Volume: 94 Page(s): 12A - 12A
    11/15/1999 Authors: Adams BK; Davis MC; Ferstl EM; Snyder JP; Liotta DC; Rickles FR; Shoji M
  • Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor.
    Proc Natl Acad Sci U S A Volume: 96 Page(s): 8663 - 8668
    07/20/1999 Authors: Abe K; Shoji M; Chen J; Bierhaus A; Danave I; Micko C; Casper K; Dillehay DL; Nawroth PP; Rickles FR
  • Activation of coagulation and angiogenesis in cancer: immunohistochemical localization in situ of clotting proteins and vascular endothelial growth factor in human cancer.
    Am J Pathol Volume: 152 Page(s): 399 - 411
    02/01/1998 Authors: Shoji M; Hancock WW; Abe K; Micko C; Casper KA; Baine RM; Wilcox JN; Danave I; Dillehay DL; Matthews E
  • Hyperexpression of the tissue factor (TF) gene in human tumor cells results in high vascular endothelial growth factor (VEGF) production in vitro and increased vascular permeability in vivo
    THROMBOSIS AND HAEMOSTASIS Page(s): OC800 - OC800
    06/01/1997 Authors: Rickles F; Shoji M; Abe K; Wilcox J; Dillehay A; Danave I; Micko C; Ross C; Nawroth P
  • Molecular mechanisms linking thrombosis and angiogenesis in cancer.
    Trends Cardiovasc Med Volume: 7 Page(s): 52 - 59
    02/01/1997 Authors: Shoji M; Abe K; Nawroth PP; Rickles FR
  • Tissue factor (TF) regulates the expression of vascular endothelial growth factor (VEGF) in vitro and angiogenesis in vivo in human breast cancer and melanoma.
    BLOOD Volume: 88 Page(s): 2046 - 2046
    11/15/1996 Authors: Shoji M; Abe K; Dillehay D; Casper K; Micko C; Danave I; Nawroth PP; Rickles F
  • The effect of edelfosine on CTP:cholinephosphate cytidylyltransferase activity in leukemic cell lines.
    Leuk Res Volume: 20 Page(s): 947 - 951
    01/01/1996 Authors: Vogler WR; Shoji M; Hayzer DJ; Xie YP; Renshaw M
  • Megakaryocytic differentiation of a leukemic cell line, MC3, by phorbol ester: induction of glycoprotein IIb/IIIa and effects on expression of IL-6, IL-6 receptor, mpl and GATA genes.
    Leuk Res Volume: 19 Page(s): 933 - 943
    12/01/1995 Authors: Okabe M; Kunieda Y; Shoji M; Nakane S; Kurosawa M; Tanaka J; Hansen SR; Asaka M
  • Establishment and characterization of a new Ph1-positive chronic myeloid leukemia cell line MC3 with trilineage phenotype and an altered p53 gene.
    Leuk Lymphoma Volume: 16 Page(s): 493 - 503
    02/01/1995 Authors: Okabe M; Kunieda Y; Nakane S; Kurosawa M; Itaya T; Vogler WR; Shoji M; Miyazaki T
  • Alternative splicing of the mRNA encoding baboon glycoprotein receptor GPIIb.
    Gene Volume: 151 Page(s): 267 - 271
    12/30/1994 Authors: Hayzer DJ; Shoji M; Kim TM; Runge MS; Hanson SR
  • Effect of herbimycin A, an inhibitor of tyrosine kinase, on protein tyrosine kinase activity and phosphotyrosyl proteins of Ph1-positive leukemia cells.
    Leuk Res Volume: 18 Page(s): 213 - 220
    03/01/1994 Authors: Okabe M; Kawamura K; Miyagishima T; Itaya T; Goodwyn D; Shoji M; Vogler WR; Sakurada K; Uehara M; Miyazaki T
  • Different mechanisms of inhibition by alkyl-lysophospholipid and phorbol ester of granulocyte-macrophage colony-stimulating factor binding to human leukemic cell lines.
    Exp Hematol Volume: 22 Page(s): 13 - 18
    01/01/1994 Authors: Shoji M; Fukuhara T; Winton EF; Berdel WE; Vogler WR
  • Establishment and characterization of a new Ph1-positive ALL cell line (ALL/MIK) presenting bcr gene rearrangement on bcr-2 and ALL-type bcr/abl transcript: suggestion of in vitro differentiation to monocytoid lineage.
    Leuk Lymphoma Volume: 12 Page(s): 287 - 296
    01/01/1994 Authors: Higa T; Okabe M; Kunieda Y; Kodama S; Itaya T; Kurosawa M; Sakurada K; Maekawa I; Shoji M; Kasai M
  • Human and baboon integrin beta 5 subunit-encoding mRNAs have alternative polyadenylation sites.
    Gene Volume: 133 Page(s): 307 - 308
    11/15/1993 Authors: Shoji M; Hayzer DJ; Kim TM; Runge MS; Hanson SR
  • Structure-function relationships of alkyl-lysophospholipid analogs in selective antitumor activity.
    Lipids Volume: 28 Page(s): 511 - 516
    06/01/1993 Authors: Vogler WR; Olson AC; Hajdu J; Shoji M; Raynor R; Kuo JF
  • Characterization of a cDNA encoding the beta-chain of baboon receptor glycoprotein GPIb.
    Gene Volume: 127 Page(s): 271 - 272
    05/30/1993 Authors: Hayzer DJ; Shoji M; Kim TM; Runge MS; Hanson SR
  • Comparison of selective cytotoxicity of alkyl lysophospholipids.
    Lipids Volume: 26 Page(s): 1418 - 1423
    12/01/1991 Authors: Vogler WR; Olson AC; Okamoto S; Shoji M; Raynor RL; Kuo JF; Berdel WE; Eibl H; Hajdu J; Nomura H
  • Effects of hexadecylphosphocholine on protein kinase C and TPA-induced differentiation of HL60 cells.
    Lipids Volume: 26 Page(s): 145 - 149
    02/01/1991 Authors: Shoji M; Raynor RL; Fleer EA; Eibl H; Vogler WR; Kuo JF
  • Inhibition of protein kinase C, (sodium plus potassium)-activated adenosine triphosphatase, and sodium pump by synthetic phospholipid analogues.
    Cancer Res Volume: 50 Page(s): 3025 - 3031
    05/15/1990 Authors: Zheng B; Oishi K; Shoji M; Eibl H; Berdel WE; Hajdu J; Vogler WR; Kuo JF
  • Fluorimetric studies of protein kinase C interactions with phospholipids.
    Biochem Biophys Res Commun Volume: 159 Page(s): 495 - 500
    03/15/1989 Authors: Rodriguez-Paris JM; Shoji M; Yeola S; Liotta D; Vogler WR; Kuo JF
  • Protein kinase C in cell growth and differentiation.
    Adv Exp Med Biol Volume: 255 Page(s): 8 - 20
    01/01/1989 Authors: Kuo JF; Shoji M; Kiss Z; Girard PR; Deli E; Oishi K; Vogler WR
  • Effects of thioether phospholipid BM 41.440 on protein kinase C and phorbol ester-induced differentiation of human leukemia HL60 and KG-1 cells.
    Cancer Res Volume: 48 Page(s): 6669 - 6673
    12/01/1988 Authors: Shoji M; Raynor RL; Berdel WE; Vogler WR; Kuo JF
  • Surgical therapy in two patients with pedunculated hepatocellular carcinoma.
    Arch Surg Volume: 123 Page(s): 772 - 774
    06/01/1988 Authors: Moritz MW; Shoji M; Sicard GA; Shioda R; DeSchryver K
  • EFFECTS OF ALKYL-LYSOPHOSPHOLIPIDS ON PHOSPHATIDYLCHOLINE BIOSYNTHESIS IN LEUKEMIC-CELL LINES
    JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY Volume: 65 Page(s): 516 - 516
    04/01/1988 Authors: VOGLER WR; OLSON AC; KISS Z; SHOJI M; KUO JF
  • EFFECTS OF VARIOUS AGENTS ON 12-O-TETRADECANOYLPHORBOL 13-ACETATE-INDUCED DOWN-REGULATION AND TRANSLOCATION OF PROTEIN KINASE-C IN HL60 LEUKEMIC-CELLS
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH Volume: 29 Page(s): 4 - 4
    03/01/1988 Authors: SHOJI M; VOGLER WR; KUO JF
  • Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
    Cancer Res Volume: 47 Page(s): 6363 - 6370
    12/01/1987 Authors: Shoji M; Girard PR; Charp PA; Koeffler HP; Vogler WR; Kuo JF
  • CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS HAVE INCREASED PROTEIN-KINASE-C ACTIVITY AS COMPARED TO NORMAL PERIPHERAL-BLOOD LYMPHOCYTES
    CLINICAL RESEARCH Volume: 35 Page(s): A428 - A428
    04/01/1987 Authors: MALIK I; SHOJI M; KUO JF; TERPENNING M
  • EFFECT OF DIETARY SUPPLEMENTATION WITH FISH OILS ON PROTEIN-KINASE-C ACTIVITY OF LYMPHOCYTES
    CLINICAL RESEARCH Volume: 35 Page(s): A460 - A460
    04/01/1987 Authors: MALIK I; SHOJI M; KUO J; TERPENNING M
  • Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
    Cancer Res Volume: 47 Page(s): 1302 - 1307
    03/01/1987 Authors: Kiss Z; Deli E; Shoji M; Koeffler HP; Pettit GR; Vogler WR; Kuo JF
  • Effects of selenium compounds on phospholipid/Ca2+-dependent protein kinase (protein kinase C) system from human leukemic cells.
    Cancer Res Volume: 46 Page(s): 3684 - 3687
    07/01/1986 Authors: Su HD; Shoji M; Mazzei GJ; Vogler WR; Kuo JF
  • Immunocytochemical evidence for phorbol ester-induced protein kinase C translocation in HL60 cells.
    Biochem Biophys Res Commun Volume: 135 Page(s): 1144 - 1149
    03/28/1986 Authors: Shoji M; Girard PR; Mazzei GJ; Vogler WR; Kuo JF
  • Phospholipid/calcium-dependent protein kinase (protein kinase C) system: a major site of bioregulation.
    Adv Enzyme Regul Volume: 25 Page(s): 387 - 400
    01/01/1986 Authors: Kuo JF; Shoji M; Girard PR; Mazzei GJ; Turner RS; Su HD
  • Inhibition of phospholipid/Ca2+-dependent protein kinase and phosphorylation of leukemic cell proteins by CP-46,665-1, a novel antineoplastic lipoidal amine.
    Biochem Biophys Res Commun Volume: 127 Page(s): 590 - 595
    03/15/1985 Authors: Shoji M; Vogler WR; Kuo JF
  • Phospholipid-sensitive Ca2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid.
    Cancer Res Volume: 43 Page(s): 2955 - 2961
    06/01/1983 Authors: Helfman DM; Barnes KC; Kinkade JM; Vogler WR; Shoji M; Kuo JF
  • Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine.
    Proc Natl Acad Sci U S A Volume: 78 Page(s): 4813 - 4817
    08/01/1981 Authors: Katoh N; Wrenn RW; Wise BC; Shoji M; Kuo JF
  • Purification to homogeneity and general properties of a novel phosphodiesterase hydrolyzing cyclic CMP and cyclic AMP.
    J Biol Chem Volume: 256 Page(s): 6327 - 6334
    06/25/1981 Authors: Helfman DM; Shoji M; Kuo JF
  • INHIBITION BY PALMITOYLCARNITINE OF CALCIUM-DEPENDENT PROTEIN-PHOSPHORYLATION SYSTEMS STIMULATED BY PHOSPHOLIPID OR CALMODULIN IN HEART
    FEDERATION PROCEEDINGS Volume: 40 Page(s): 1722 - 1722
    01/01/1981 Authors: WISE BC; KATOH N; WRENN RW; RAYNOR RL; SCHATZMAN RC; SHOJI M; KUO JF
  • SUBCELLULAR-DISTRIBUTION IN HEART OF SUBSTRATE PROTEINS FOR CALCIUM-DEPENDENT PROTEIN-PHOSPHORYLATION SYSTEMS STIMULATED BY PHOSPHOLIPID OR CALMODULIN
    FEDERATION PROCEEDINGS Volume: 40 Page(s): 655 - 655
    01/01/1981 Authors: KATOH N; WRENN RW; WISE BC; SHOJI M; KUO JF
  • TROPHIC EFFECT OF TUMOR ON VISCERAL ORGANS
    CLINICAL RESEARCH Volume: 29 Page(s): A844 - A844
    01/01/1981 Authors: STEVENS V; SHOJI M; HEYMSFIELD S
  • Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.
    Proc Natl Acad Sci U S A Volume: 77 Page(s): 7039 - 7043
    12/01/1980 Authors: Kuo JF; Andersson RG; Wise BC; Mackerlova L; Salomonsson I; Brackett NL; Katoh N; Shoji M; Wrenn RW
  • Elevated plasma and urinary guanosine 3':5'-monophosphate and increased production rate in patients with neoplastic diseases.
    Cancer Res Volume: 40 Page(s): 3915 - 3920
    11/01/1980 Authors: Chawla RK; Shlaer SM; Lawson DH; Murray TG; Schmidt F; Shoji M; Nixon DW; Richmond A; Rudman D
  • Stimulatory modulator-requiring cyclic nucleotide-independent protein kinase: partial purification from fetal calf hearts and comparison with various protein kinases.
    Biochem Biophys Res Commun Volume: 96 Page(s): 128 - 134
    09/16/1980 Authors: Shoji M; May DA; Wise BC; Kuo JF
  • Decrease or increase in cardiac muscarinic cholinergic receptor number in rats treated with methacholine or atropine.
    Biochem Biophys Res Commun Volume: 92 Page(s): 1136 - 1142
    02/27/1980 Authors: Wise BC; Shoji M; Kuo JF
  • PHOSPHOLIPID-REQUIRED CALCIUM-DEPENDENT PROTEIN-KINASE - WIDESPREAD OCCURRENCE, INVOLVEMENT IN ONTOGENY, AND ENDOGENOUS SUBSTRATE PROTEINS IN BRAIN AND OTHER TISSUES
    FEDERATION PROCEEDINGS Volume: 39 Page(s): 1625 - 1625
    01/01/1980 Authors: WRENN RW; ANDERSSON RGG; WISE BC; KATOH N; SHOJI M; GROTH DP; KUO JF
  • GUANOSINE 3'-5' MONOPHOSPHATE IN CANCER
    FEDERATION PROCEEDINGS Volume: 39 Page(s): 743 - 743
    01/01/1980 Authors: CHAWLA RK; MURRAY TJ; LAWSON DH; SHOJI M; RUDMAN D
  • CYTIDINE 3'-5'-MONOPHOSPHATE (CCMP) PHOSPHODIESTERASE - PURIFICATION TO APPARENT HOMOGENEITY FROM PIG-LIVER USING AFFINITY-CHROMATOGRAPHY
    FEDERATION PROCEEDINGS Volume: 39 Page(s): 1955 - 1955
    01/01/1980 Authors: HELFMAN DM; SHOJI M; KUO JF
  • Plasma and urine cyclic guanosine 3':5'-monophosphate in disseminated cancer.
    Ann Intern Med Volume: 91 Page(s): 862 - 864
    12/01/1979 Authors: Chawla RK; Nixon DW; Shoji M; Rudman D
  • OPPOSITE CHANGES IN CARDIAC MUSCARINIC CHOLINERGIC RECEPTORS INDUCED BY METHACHOLINE AND ATROPINE
    FEDERATION PROCEEDINGS Volume: 38 Page(s): 269 - 269
    01/01/1979 Authors: WISE BC; SHOJI M; KUO JF
  • CYCLIC CMP PHOSPHODIESTERASE - BIOLOGICAL INVOLVEMENT AND ITS REGULATION BY AGENTS
    JOURNAL OF SUPRAMOLECULAR STRUCTURE Page(s): 9 - 9
    01/01/1979 Authors: KUO JF; SHOJI M; HELFMAN DM
  • Effects of phosphodiesterase inhibitors, imidazole and phosphate on cyclic CMP phosphodiesterase are different from those on cyclic AMP and cyclic GMP phosphodiesterases.
    J Cyclic Nucleotide Res Volume: 4 Page(s): 463 - 474
    12/01/1978 Authors: Kuo JF; Shoji M; Brackett NL; Helfman DM
  • Cytidine 3',5'-monophosphate phosphodiesterase: decreased activity in the regenerating and developing liver.
    Science Volume: 201 Page(s): 826 - 828
    09/01/1978 Authors: Shoji M; Brackett NL; Kuo JF
  • Decreased activity of cytidine 3':5'-monophosphate (cyclic CMP) phosphodiesterase in the fast-growing Morris hepatoma 3924A, but not in the slow-growing Morris hepatoma 9618A.
    Biochem Biophys Res Commun Volume: 83 Page(s): 1140 - 1146
    08/14/1978 Authors: Shoji M; Brackett NL; Helfman DM; Morris HP; Kuo JF
  • Molecular properties and mode of action of homogeneous preparation of stimulatory modulator of cyclic GMP-dependent protein kinase from the heart.
    J Biol Chem Volume: 253 Page(s): 3427 - 3434
    05/25/1978 Authors: Shoji M; Brackett NL; Tse J; Shapira R; Kuo JF
  • Cytidine 3':5'-monophosphate phosphodiesterase in mammalian tissues. Occurrence and biological involvement.
    J Biol Chem Volume: 253 Page(s): 2518 - 2521
    04/25/1978 Authors: Kuo JF; Brackett NL; Shoji M; Tse J
  • Mammalian cyclic GMP-dependent protein kinase and its stimulatory modulator.
    Adv Cyclic Nucleotide Res Volume: 9 Page(s): 199 - 207
    01/01/1978 Authors: Kuo JF; Shoji M; Kuo WN
  • CYTIDINE 3'-5'-MONOPHOSPHATE PHOSPHODIESTERASE IN MAMMALIAN-TISSUES - OCCURRENCE AND BIOLOGICAL INVOLVEMENT
    FEDERATION PROCEEDINGS Volume: 37 Page(s): 1538 - 1538
    01/01/1978 Authors: KUO JF; BRACKETT NL; SHOJI M; TSE J
  • Molecular and physiopathologic aspects of mammalian cyclic GMP-dependent protein kinase.
    Annu Rev Pharmacol Toxicol Volume: 18 Page(s): 341 - 355
    01/01/1978 Authors: Kuo JF; Shoji M; Kuo WN
  • Involvements of cyclic nucleotide systems in enlarged mice lungs produced by butylated hydroxytoluene.
    Biochem Pharmacol Volume: 27 Page(s): 1671 - 1675
    01/01/1978 Authors: Kuo JF; Brackett NL; Stubbs JW; Shoji M; Helfman DM
  • Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect.
    Biochim Biophys Acta Volume: 500 Page(s): 419 - 424
    12/22/1977 Authors: Shoji M; Morris HP; Davis CW; Brackett NL; Kuo JF
  • Studies on the cyclic GMP-dependent protein kinase from bovine aorta. Possible existence of a catalytic subunit.
    J Biol Chem Volume: 252 Page(s): 4347 - 4353
    06/25/1977 Authors: Shoji M; Patrick JG; Tse J; Kuo JF
  • Isolation and characterization of the glycoprotein (JBB5) in the urine of a patient with carcinoma of the colon.
    Cancer Res Volume: 37 Page(s): 873 - 878
    03/01/1977 Authors: Chawla RK; Heymsfield SB; Wadsworth AA; Shoji M; Rudman D
  • Urinary excretion of the cancer-related glycoprotein EDCl: effect of chemotherapy.
    Ann Intern Med Volume: 86 Page(s): 174 - 179
    02/01/1977 Authors: Rudman D; Chawla RK; Heymsfield SB; Bethel RA; Shoji M; Vogler R; Nixon DW
  • Guanosine cyclic monophosphate-dependent protein kinase from foetal calf heart. Purification, general properties and catalytic subunit.
    Biochem J Volume: 161 Page(s): 213 - 221
    02/01/1977 Authors: Shoji M; Patrick JG; Davis CW; Kuo JF
  • DIAGNOSTIC CAPABILITY OF RADIOIMMUNOASSAY FOR CANCER-RELATED ANTIGEN EDCL IN 7 TYPES OF CANCER
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH Volume: 18 Page(s): 135 - 135
    01/01/1977 Authors: RUDMAN D; GROTH DP; VOGLER WR; SHOJI M; NIXON DW
  • NOVEL GLYCOPROTEIN IN URINE OF A PATIENT WITH CARCINOMA OF COLON
    FEDERATION PROCEEDINGS Volume: 36 Page(s): 1326 - 1326
    01/01/1977 Authors: CHAWLA RK; HEYMSFIELD SB; WADSWORTH AD; SHOJI M; RUDMAN D
  • Stimulatory modulator of guanosine 3':5'-monophosphate-dependent protein kinase from mammalian tissues.
    Biochim Biophys Acta Volume: 437 Page(s): 142 - 149
    06/23/1976 Authors: Kuo WN; Shoji M; Kuo JF
  • Isolation of stimulatory modulator from rat brain and its specific effect on guanosine 3':5'-monophosphate-dependent protein kinase from cerebellum and other tissues.
    Biochem Biophys Res Commun Volume: 70 Page(s): 280 - 286
    05/03/1976 Authors: Kuo WN; Shoji M; Kuo JF
  • Purification and general properties of guanosine 3':5'-monophosphate-dependent protein kinase from guinea pig fetal lung.
    J Biol Chem Volume: 251 Page(s): 1759 - 1766
    03/25/1976 Authors: Kuo JF; Kuo WN; Shoji M; Davis CW; Seery VL; Donnelly TE
  • STIMULATORY MODULATOR OF CYCLIC GMP-DEPENDENT PROTEIN KINASE FROM MAMMALIAN-TISSUES
    FEDERATION PROCEEDINGS Volume: 35 Page(s): 584 - 584
    01/01/1976 Authors: KUO WN; SHOJI M; KUO JF
  • Regulation by cyclic GMP and stimulatory protein kinase modulator of cyclic GMP-dependent protein kinase from brain and other tissues.
    Adv Biochem Psychopharmacol Volume: 15 Page(s): 379 - 389
    01/01/1976 Authors: Kuo JF; Kuo WN; Shoji M
  • Effects of hydrocortisone on the yield and bactericidal function of granulocytes collected by continuous-flow centrifugation.
    Blood Volume: 44 Page(s): 435 - 443
    09/01/1974 Authors: Shoji M; Vogler WR
  • Cellular hypersensitivity: the production of antibody by cultures of lymphocytes producing macrophage inhibitory factor.
    Cell Immunol Volume: 3 Page(s): 442 - 447
    03/01/1972 Authors: Meyers OL; Shoji M; Haber E; Remold HG; David JR
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