Mandy Ford
Overview
Dr. Ford is a leading researcher in the study of the cellular mechanisms of T cell responses in transplantation and immunosuppression, and her work is funded by various federal, foundation, and industry grant awards. She was a vital member of the Emory research team led by Dr. Christian Larsen and Dr. Thomas Pearson that helped develop belatacept as a successful new class of immunosuppressant. The sophisticated research strategies and techniques she brought to the team were integral to its success in showing that belatacept could provide patients with a less toxic treatment and a better chance for long-term function and survival of the transplanted organ.
Dr. Ford is a vital member of the Emory research team currently spearheading new efforts to develop novel third-generation costimulation blockers as better and less toxic immunosuppression in clinical transplantation. Based on her foundational studies in experimental transplant models over the last 10 years in collaboration with Dr. Andrew Adams, this Emory team composed of Dr. Ford, Dr. Adams, and Dr. Larsen was awarded a $5.6M NIH grant to fund a clinical trial of the costimulation blocker lulizumab in 2018.
Dr. Ford's current portfolio includes two NIH R01s, several private foundation grants, the Emory Transplant Center's T32 training grant, and two R01-funded collaborative studies with Emory surgical critical care surgeon-scientist Dr. Craig Coopersmith. The studies with Dr. Coopersmith are investigating the impact of chronic alcohol abuse on the pathophysiology of sepsis, and the roots of the systemic immune dysregulation that switches on the immune suppression that is a major contributor to sepsis-induced mortality.
Academic Appointment
- Assistant Professor of Surgery, Department of Surgery Transplant Center, Emory University School of Medicine
Education
Degrees
- PhD from Emory University
- BS from University of Georgia
Research
Focus
- Cellular mechanisms of induction and modulation of allospecific T cell responses My research interests focus on donor-reactive T cell activation, programming, and memory generation during the course of transplant rejection or survival. While blockade of costimulatory molecules such as the CD28 pathway shows great promise in clinical trials, not all T cell responses are attenuated using costimulation blockers such as belatacept.
Publications
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Fgl2 regulates FcRIIB+CD8+ T cell responses during infection.
JCI Insight Volume: 10
01/01/2025 Authors: Morris AB; Adelman MW; Bennion KB; Martinez CD; McCook K-M; Woodworth MH; Langelier CR; Rouphael N; Scharer CD; Maier CL -
INTESTINAL EPITHELIAL-SPECIFIC OCCLUDIN DELETION WORSENS GUT PERMEABILITY AND SURVIVAL FOLLOWING SEPSIS.
Shock Volume: 63 Page(s): 597 - 605
04/01/2025 Authors: Yumoto T; Oami T; Liang Z; Burd EM; Ford ML; Turner JR; Coopersmith CM -
Macrophage-derived Fgl2 dampens antitumor immunity through regulation of FcRIIB+CD8+ T cells in melanoma.
JCI Insight Volume: 10
03/24/2025 Authors: Bennion KB; Miranda R Bazzano J; Liu D; Wagener M; Paulos CM; Ford ML -
Obesity reshapes regulatory T cells in the visceral adipose tissue by disrupting cellular cholesterol homeostasis.
Sci Immunol Volume: 10 Page(s): eadl4909
01/10/2025 Authors: Elkins C; Ye C; Sivasami P; Mulpur R; Diaz-Saldana PP; Peng A; Xu M; Chiang Y-P; Moll S; Rivera-Rodriguez DE -
Immune suppression sustained allograft acceptance requires PD1 inhibition of CD8+ T cells.
J Immunol Volume: 214 Page(s): 192 - 198
01/01/2025 Authors: Miller-Handley H; Harper G; Pham G; Turner LH; Shao T-Y; Russi AE; Erickson JJ; Ford ML; Araki K; Way SS -
Advancing mouse models for transplantation research.
Am J Transplant Volume: 24 Page(s): 1362 - 1368
08/01/2024 Authors: Cravedi P; Riella LV; Ford ML; Valujskikh A; Menon MC; Kirk AD; Alegre M-L; Alessandrini A; Feng S; Kehn P -
Differential induction of donor-reactive Foxp3+ regulatory T cell via blockade of CD154 vs CD40.
Am J Transplant Volume: 24 Page(s): 1369 - 1381
08/01/2024 Authors: Liu D; Yao H; Ferrer IR; Ford ML -
CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcRIIB.
Nat Commun Volume: 15 Page(s): 5280
06/20/2024 Authors: Bennion KB; Liu D; Dawood AS; Wyatt MM; Alexander KL; Abdel-Hakeem MS; Paulos CM; Ford ML -
Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis.
Proc Natl Acad Sci U S A Volume: 121 Page(s): e2217877121
03/05/2024 Authors: Oami T; Abtahi S; Shimazui T; Chen C-W; Sweat YY; Liang Z; Burd EM; Farris AB; Roland JT; Tsukita S -
The Entangled World of Memory T Cells and Implications in Transplantation.
Transplantation Volume: 108 Page(s): 137 - 147
01/01/2024 Authors: Alexander KL; Ford ML -
CTLA-4 Checkpoint Inhibition Improves Sepsis Survival in Alcohol-Exposed Mice.
Immunohorizons Volume: 8 Page(s): 74 - 88
01/01/2024 Authors: Paterson CW; Fay KT; Chen C-W; Klingensmith NJ; Gutierrez MB; Liang Z; Coopersmith CM; Ford ML -
CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice.
Front Immunol Volume: 15 Page(s): 1346097
01/01/2024 Authors: Anyalebechi JC; Sun Y; Davis C; Wagener ME; Liang Z; Burd EM; Coopersmith CM; Ford ML -
Mitochondrial metabolic flexibility is critical for CD8+ T cell antitumor immunity.
Sci Adv Volume: 9 Page(s): eadf9522
12/08/2023 Authors: Chen C; Zheng H; Horwitz EM; Ando S; Araki K; Zhao P; Li Z; Ford ML; Ahmed R; Qu C-K -
Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation.
Am J Transplant Volume: 23 Page(s): 1511 - 1525
10/01/2023 Authors: Zeng S; Crichton ES; Ford ML; Badell IR -
Candidemia in thoracic solid organ transplant recipients: Characteristics and outcomes relative to matched uninfected and bacteremic thoracic organ transplant recipients.
Clin Transplant Volume: 37 Page(s): e15038
09/01/2023 Authors: Eichenberger EM; Satola S; Neujahr D; Fowler VG; Gupta D; Ford M; Pouch SM -
FcRIIB expressed on CD8+ T cells limits responsiveness to PD-1 checkpoint inhibition in cancer.
Sci Transl Med Volume: 15 Page(s): eadd1868
08/23/2023 Authors: Bennion KB; Tariq M; Wyatt MM; Duneton C; Baecher KM; Paulos CM; Kudchadkar RR; Lowe MC; Ford ML -
CHRONIC ETHANOL USE WORSENS GUT PERMEABILITY AND ALTERS TIGHT JUNCTION EXPRESSION IN A MURINE SEPSIS MODEL.
Shock Volume: 60 Page(s): 280 - 290
08/01/2023 Authors: Oami T; Yumoto T; Shimazui T; Sarmiento S; Klingensmith NJ; Chen C-W; Otani S; Liang Z; Burd EM; Mahdi ZK -
Cancer and sepsis.
Clin Sci (Lond) Volume: 137 Page(s): 881 - 893
06/14/2023 Authors: Williams JC; Ford ML; Coopersmith CM -
Corrigendum to 'Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report' [American Journal of Transplantation 23 (2023) 133-149].
Am J Transplant Volume: 23 Page(s): 694
05/01/2023 Authors: Tambur AR; Bestard O; Campbell P; Chong AS; Crespo M; Ford ML; Gebel HM; Heidt S; Hickey M; Jackson A -
MYOSIN LIGHT CHAIN KINASE DELETION WORSENS LUNG PERMEABILITY AND INCREASES MORTALITY IN PNEUMONIA-INDUCED SEPSIS.
Shock Volume: 59 Page(s): 612 - 620
04/01/2023 Authors: Chihade DB; Smith P; Swift DA; Otani S; Zhang W; Chen C-W; Jeffers LA; Liang Z; Shimazui T; Burd EM -
TIGIT agonism alleviates costimulation blockade-resistant rejection in a regulatory T cell-dependent manner.
Am J Transplant Volume: 23 Page(s): 180 - 189
02/01/2023 Authors: Hartigan CR; Tong KP; Liu D; Laurie SJ; Ford ML -
Impact of chronic alcohol exposure on conventional and regulatory murine T cell subsets.
Front Immunol Volume: 14 Page(s): 1142614
01/01/2023 Authors: Paterson CW; Gutierrez MB; Coopersmith CM; Ford ML -
Sensitization in transplantation: Assessment of Risk 2022 Working Group Meeting Report.
Am J Transplant Volume: 23 Page(s): 133 - 149
01/01/2023 Authors: Tambur AR; Bestard O; Campbell P; Chong AS; Barrio MC; Ford ML; Gebel HM; Heidt S; Hickey M; Jackson A -
NIAID workshop on T cell technologies.
Nat Immunol Volume: 24 Page(s): 14 - 18
01/01/2023 Authors: Gondr-Lewis TA; Jiang C; Ford ML; Koelle DM; Sette A; Shalek AK; Thomas PG -
Gram-negative bacteremia in solid organ transplant recipients: Clinical characteristics and outcomes as compared to immunocompetent non-transplant recipients.
Transpl Infect Dis Volume: 24 Page(s): e13969
12/01/2022 Authors: Eichenberger EM; Troy J; Ruffin F; Dagher M; Thaden JT; Ford ML; Fowler VG -
FC gamma RIIB EXPRESSED ON CD8 T CELLS LIMITS RESPONSIVENESS TO PD-1 CHECKPOINT INHIBITION IN CANCER
Volume: 10 Page(s): A529 - A529
11/01/2022 Authors: Bennion K; Tariq M; Wyatt M; Baecher K; Paulos C; Kudchadkar R; Lowe M; Ford M -
Activation and regulation of alloreactive T cell immunity in solid organ transplantation.
Nat Rev Nephrol Volume: 18 Page(s): 663 - 676
10/01/2022 Authors: Duneton C; Winterberg PD; Ford ML -
Junctional adhesion molecule-A deletion increases phagocytosis and improves survival in a murine model of sepsis.
JCI Insight Volume: 7
08/22/2022 Authors: Klingensmith NJ; Fay KT; Swift DA; Bazzano JM; Lyons JD; Chen C-W; Meng M; Ramonell KM; Liang Z; Burd EM -
Gm2a Regulates Memory Cd8(+) T Cell Activation and Differentiation.
Volume: 22 Page(s): 744 - 744
06/01/2022 Authors: Tong KP; Baecher KM; Hartigan CR; Ford M -
Gm2a: A Novel Regulatory Pathway Controlling CD8(+) T Cell Alloimmunity.
Volume: 22 Page(s): 496 - 496
06/01/2022 Authors: Baecher KM; Bazzano J; Tong K; Fribourg M; Cravedi P; Heeger PS; Ford ML -
Chronic Ethanol Exposure Prolongs Murine Allograft Survival.
Volume: 22 Page(s): 616 - 616
06/01/2022 Authors: Swift D; Ford M; Kitchens W -
TIGIT Agonism Ameliorates Costimulation Blockade-Resistant Rejection by Increasing Quantity and Quality of Graft-Infiltrating Foxp3(+) Treg.
Volume: 22 Page(s): 586 - 587
06/01/2022 Authors: Hartigan CR; Liu D; Laurie S; Ford ML -
Protective Immunity Against a Murine Epstein-Barr Virus Homolog is Preserved During CD11b-CD154 Blockade.
Volume: 22 Page(s): 907 - 907
06/01/2022 Authors: Alexander KL; Liu D; Ford ML -
Selective CD28 blockade impacts T cell differentiation during homeostatic reconstitution following lymphodepletion.
Volume: 13 Page(s): 1081163
01/01/2022 Authors: Habib JG; Liu D; Crepeau RM; Wagener ME; Ford ML -
Intersection of FcRIIB, the microbiome, and checkpoint inhibitors in antitumor immunity.
Cancer Immunol Immunother Volume: 70 Page(s): 3397 - 3404
12/01/2021 Authors: Baecher KM; Ford ML -
Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis.
Shock Volume: 56 Page(s): 621 - 628
10/01/2021 Authors: Sun Y; Oami T; Liang Z; Miniet AA; Burd EM; Ford ML; Coopersmith CM -
TIGIT regulates apoptosis of risky memory T cell subsets implicated in belatacept-resistant rejection.
Am J Transplant Volume: 21 Page(s): 3256 - 3267
10/01/2021 Authors: Sun H; Hartigan CR; Chen C-W; Sun Y; Tariq M; Robertson JM; Krummey SM; Mehta AK; Ford ML -
Time for increased awareness of sex as a biological variable in transplantation.
Am J Transplant Volume: 21 Page(s): 3215 - 3216
10/01/2021 Authors: Ford ML; Mannon RB -
DECREASED CD28 EXPRESSION IN MEMORY CD4+T CELLS IN CHILDREN AWAITING KIDNEY TRANSPLANT IS ASSOCIATED WITH INCREASED EXPRESSION OF SENESCENCE MARKERS
Volume: 36 Page(s): 3317 - 3317
10/01/2021 Authors: Duneton C; George R; Ford M; Winterberg P -
TIGIT modulates sepsis-induced immune dysregulation in mice with preexisting malignancy.
JCI Insight Volume: 6
06/08/2021 Authors: Zhang W; Anyalebechi JC; Ramonell KM; Chen C-W; Xie J; Liang Z; Chihade DB; Otani S; Coopersmith CM; Ford ML -
TIGIT Agonism Improves Immunosuppression of Cd8 T Cells by Ctla-4ig in a Treg Dependent Manner
Volume: 21 Page(s): 396 - 396
06/01/2021 Authors: Hartigan CR; Liu D; Ford ML -
Evaluation of the Differentiation Program of Endogenous Antigen-specific CD8(+)T Cells Following Transplantation
Volume: 21 Page(s): 540 - 540
06/01/2021 Authors: Krummey SM; Tong K; Ford ML -
Gm2a: A Novel Regulatory Pathway Controlling Alloimmunity
Volume: 21 Page(s): 459 - 459
06/01/2021 Authors: Baecher KM; Heeger PS; Cravedi P; Fribourg M; Ford ML -
Tumor-Specific T Cells Exacerbate Mortality and Immune Dysregulation during Sepsis.
Volume: 206 Page(s): 2412 - 2419
05/15/2021 Authors: Chen C-W; Bennion KB; Swift DA; Morrow KN; Zhang W; Oami T; Coopersmith CM; Ford ML -
Optimization of de novo belatacept-based immunosuppression administered to renal transplant recipients.
Am J Transplant Volume: 21 Page(s): 1691 - 1698
05/01/2021 Authors: Kirk AD; Adams AB; Durrbach A; Ford ML; Hildeman DA; Larsen CP; Vincenti F; Wojciechowski D; Woodle ES -
Anti-TIGIT differentially affects sepsis survival in immunologically experienced versus previously naive hosts.
JCI Insight Volume: 6
03/08/2021 Authors: Sun Y; Anyalebechi JC; Sun H; Yumoto T; Xue M; Liu D; Liang Z; Coopersmith CM; Ford ML -
FcRIIB is a T cell checkpoint in antitumor immunity.
JCI Insight Volume: 6
02/22/2021 Authors: Farley CR; Morris AB; Tariq M; Bennion KB; Potdar S; Kudchadkar R; Lowe MC; Ford ML -
The IL-27 receptor regulates TIGIT on memory CD4+ T cells during sepsis.
iScience Volume: 24 Page(s): 102093
02/19/2021 Authors: Morrow KN; Liang Z; Xue M; Chihade DB; Sun Y; Chen C-W; Coopersmith CM; Ford ML -
Superior inhibition of alloantibody responses with selective CD28 blockade is CTLA-4 dependent and T follicular helper cell specific.
Am J Transplant Volume: 21 Page(s): 73 - 86
01/01/2021 Authors: La Muraglia GM; Zeng S; Crichton ES; Wagener ME; Ford ML; Badell IR -
CD28 Agonism Improves Survival in Immunologically Experienced Septic Mice via IL-10 Released by Foxp3+ Regulatory T Cells.
J Immunol Volume: 205 Page(s): 3358 - 3371
12/15/2020 Authors: Sun Y; Xie J; Anyalebechi JC; Chen C-W; Sun H; Xue M; Liang Z; Morrow KN; Coopersmith CM; Ford ML -
Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report.
Am J Transplant Volume: 20 Page(s): 2652 - 2668
10/01/2020 Authors: Tambur AR; Campbell P; Chong AS; Feng S; Ford ML; Gebel H; Gill RG; Kelsoe G; Kosmoliaptsis V; Mannon RB -
TOXic signaling: How antigen accelerates T cell exhaustion during transplantation.
Am J Transplant Volume: 20 Page(s): 2303 - 2304
09/01/2020 Authors: Ford ML -
CD11b is a novel alternate receptor for CD154 during alloimmunity.
Am J Transplant Volume: 20 Page(s): 2216 - 2225
08/01/2020 Authors: Liu D; Ford ML -
Memory T cell-mediated rejection is mitigated by FcRIIB expression on CD8+ T cells.
Am J Transplant Volume: 20 Page(s): 2206 - 2215
08/01/2020 Authors: Morris AB; Pinelli DF; Liu D; Wagener M; Ford ML -
ANTI-CTLA-4-INDUCED SURVIVAL INCREASE IN A MURINE MODEL OF SEPSIS FOLLOWING CHRONIC ALCOHOL EXPOSURE IS ASSOCIATED WITH EFFECTOR T-REG GENERATION
Volume: 53 Page(s): 22 - 22
06/01/2020 Authors: Paterson C; Ford M; Coopersmith CM -
IL-27 SIGNALING IS ASSOCIATED WITH INCREASED LAG-3 EXPRESSION ON CD4(+) T CELLS IN SEPSIS
Volume: 53 Page(s): 107 - 107
06/01/2020 Authors: Morrow K; Liang Z; Xue M; Chihade D; Sun Y; Chen C-W; Coopersmith CM; Ford M -
Programmed T cell differentiation: Implications for transplantation.
Cell Immunol Volume: 351 Page(s): 104099
05/01/2020 Authors: Crepeau RL; Ford ML -
CD28-Dependent CTLA-4 Expression Fine-Tunes the Activation of Human Th17 Cells.
iScience Volume: 23 Page(s): 100912
04/24/2020 Authors: Krummey SM; Hartigan CR; Liu D; Ford ML -
Breaking the bond between tetranectin and HMGB1 in sepsis.
Sci Transl Med Volume: 12
04/15/2020 Authors: Paterson CW; Ford ML; Coopersmith CM -
Targeting Th17: TIGIT as a Key Regulator of Tregs/Th17 Cells in Belatacept Resistant Rejection
Volume: 20 Page(s): 746 - 746
04/01/2020 Authors: Hartigan CR; Wagener M; Ford ML -
Effector Differentiation of Endogenous Antigen-Specific CD8(+) T Cells is Selectively Limited by CTLA-4 Ig
Volume: 20 Page(s): 633 - 633
04/01/2020 Authors: Krummey SM; Tong KP; Ford ML -
Chronic Kidney Disease Alters the T Cell Response to Murine Cytomegalovirus
Volume: 20 Page(s): 745 - 746
04/01/2020 Authors: Crepeau RL; Li H; Koehler HS; Ford ML; Winterberg PD -
CD11b is a Novel Alternate Receptor for CD154 During Alloimmunity
Volume: 20 Page(s): 299 - 299
04/01/2020 Authors: Ford ML; Liu D -
Role of CD28 Signaling on T cell Phenotype following Lymphodepletion and Homeostatic Reconstitution
Volume: 34
04/01/2020 Authors: Sood N; Crepeau R; Liu D; Ford M -
Preexisting malignancy abrogates the beneficial effects of CXCR4 blockade during sepsis.
J Leukoc Biol Volume: 107 Page(s): 485 - 495
03/01/2020 Authors: Zhang W; Chihade DB; Xie J; Chen C-W; Ramonell KM; Liang Z; Coopersmith CM; Ford ML -
CD45RB Status of CD8+ T Cell Memory Defines T Cell Receptor Affinity and Persistence.
Cell Rep Volume: 30 Page(s): 1282 - 1291.e5
02/04/2020 Authors: Krummey SM; Morris AB; Jacobs JR; McGuire DJ; Ando S; Tong KP; Zhang W; Robertson J; Guasch SA; Araki K -
The impact of belatacept on third-party HLA alloantibodies in highly sensitized kidney transplant recipients.
Am J Transplant Volume: 20 Page(s): 573 - 581
02/01/2020 Authors: Parsons RF; Zahid A; Bumb S; Decker H; Sullivan HC; Eun-Hyung Lee F; Badell IR; Ford ML; Larsen CP; Pearson TC -
Signaling through the Inhibitory Fc Receptor FcRIIB Induces CD8+T Cell Apoptosis to Limit T Cell Immunity.
Immunity Volume: 52 Page(s): 136 - 150.e6
01/14/2020 Authors: Morris AB; Farley CR; Pinelli DF; Adams LE; Cragg MS; Boss JM; Scharer CD; Fribourg M; Cravedi P; Heeger PS -
Correction: Chronic Alcohol Ingestion Increases Mortality and Organ Injury in a Murine Model of Septic Peritonitis.
PLoS One Volume: 15 Page(s): e0239568
01/01/2020 Authors: Yoseph BP; Breed E; Overgaard CE; Ward CJ; Liang Z; Wagener ME; Lexcen DR; Lusczek ER; Beilman GJ; Burd EM -
Circulating T follicular helper cells are a biomarker of humoral alloreactivity and predict donor-specific antibody formation after transplantation.
Am J Transplant Volume: 20 Page(s): 75 - 87
01/01/2020 Authors: La Muraglia GM; Wagener ME; Ford ML; Badell IR -
When rubber meets the road: how innate features of adaptive immune cells play critical roles in transplant alloimmunity.
Curr Opin Organ Transplant Volume: 24 Page(s): 659 - 663
12/01/2019 Authors: Morris AB; Ford ML -
2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy.
JCI Insight Volume: 4
11/14/2019 Authors: Chen C-W; Xue M; Zhang W; Xie J; Coopersmith CM; Ford ML -
Regulation of T and B cell responses to chronic antigenic stimulation during Infection, autoimmunity and transplantation.
Immunol Rev Volume: 292 Page(s): 5 - 8
11/01/2019 Authors: Ahmed R; Ford ML; Sanz I -
Memory T-cell exhaustion and tolerance in transplantation.
Immunol Rev Volume: 292 Page(s): 225 - 242
11/01/2019 Authors: Hartigan CR; Sun H; Ford ML -
The gut microbiome alters immunophenotype and survival from sepsis.
FASEB J Volume: 33 Page(s): 11258 - 11269
10/01/2019 Authors: Fay KT; Klingensmith NJ; Chen C-W; Zhang W; Sun Y; Morrow KN; Liang Z; Burd EM; Ford ML; Coopersmith CM -
Impact of selective CD28 blockade on virus-specific immunity to a murine Epstein-Barr virus homolog.
Am J Transplant Volume: 19 Page(s): 2199 - 2209
08/01/2019 Authors: Crepeau RL; Elengickal JA; La Muraglia GM; Ford ML -
Murine Pancreatic Cancer Alters T Cell Activation and Apoptosis and Worsens Survival After Cecal Ligation and Puncture.
Shock Volume: 51 Page(s): 731 - 739
06/01/2019 Authors: Lyons JD; Chen C-W; Liang Z; Zhang W; Chihade DB; Burd EM; Farris AB; Ford ML; Coopersmith CM -
IMPACT OF IL-27 SIGNALING IN MEMORY T CELLS ON SEPSIS PATHOPHYSIOLOGY
Volume: 51 Page(s): 99 - 99
06/01/2019 Authors: Morrow KN; Chen C-W; Sun Y; Xie J; Chihade DB; Coopersmith CM; Ford ML -
IMPACT OF CANCER ON IMMUNE DYSREGULATION DURING SEPSIS
Volume: 51 Page(s): 40 - 40
06/01/2019 Authors: Ford ML -
MECHANISMS UNDERLYING DECREASED MORTALITY WITH CTLA-4 CHECKPOINT INHIBITION IN A MODEL OF MURINE SEPSIS WITH PREMORBID CHRONIC ALCOHOL EXPOSURE
Volume: 51 Page(s): 23 - 24
06/01/2019 Authors: Paterson LTCW; Coopersmith CM; Ford ML -
ANTI-CD28 ANTIBODY IMPROVES SURVIVAL IN "MEMORY MICE'' WITH SEPSIS VIA IL-10 RELEASED BY REGULATORY T CELLS
Volume: 51 Page(s): 122 - 122
06/01/2019 Authors: Sun Y; Chen C-W; Liang Z; Zhang W; Coopersmith CM; Ford ML -
Increased attrition of memory T cells during sepsis requires 2B4.
JCI Insight Volume: 4
05/02/2019 Authors: Xie J; Chen C-W; Sun Y; Laurie SJ; Zhang W; Otani S; Martin GS; Coopersmith CM; Ford ML -
Chronic Alcohol Ingestion Worsens Survival and Alters Gut Epithelial Apoptosis and CD8+ T Cell Function After Pseudomonas Aeruginosa Pneumonia-Induced Sepsis.
Shock Volume: 51 Page(s): 453 - 463
04/01/2019 Authors: Klingensmith NJ; Fay KT; Lyons JD; Chen C-W; Otani S; Liang Z; Chihade DB; Burd EM; Ford ML; Coopersmith CM -
Fc gamma RIIB is a Novel CD8+Effector T Cell Intrinsic Regulatory Pathway That Correlates with Freedom from Rejection in Renal Transplant Patients.
Volume: 19 Page(s): 566 - 566
04/01/2019 Authors: Morris AB; Pinelli DF; Liu D; Boss JM; Scharer CD; Fribourg M; Cravedi P; Heeger PS; Ford ML -
Cd45rb Mediates Cd8+T Cell Persistence In An Allogeneic Heterologous Immune Response.
Volume: 19 Page(s): 1086 - 1087
04/01/2019 Authors: Krummey SM; Morris AB; Ford ML -
Impact Of Selective Cd28 Blockade On Protective Immunity To A Murine Epstein-Barr Virus Homolog.
Volume: 19 Page(s): 428 - 428
04/01/2019 Authors: Crepeau RL; Elengickal JA; Ford ML -
Selective CD28 Blockade-Mediated Inhibition of T Follicular Helper Cell and DSA Responses is CTLA-4 Dependent.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 19 Page(s): 565 - 565
04/01/2019 Authors: La Muraglia GM; Ford ML; Badell IR -
Effect of Chronic Kidney Disease on Allo-Immune Response in Mice.
Volume: 19 Page(s): 595 - 595
04/01/2019 Authors: Winterberg PD; Li H; Wagener ME; Ford ML -
lCOS+PD-1+Circulating T Follicular Helper Cells Are a Biomarker of Humoral Alloreactisity and Predict Donor-Specific Antibody Generation Following Transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 19 Page(s): 758 - 758
04/01/2019 Authors: La Muraglia GM; Wagener ME; Ford ML; Badell IR -
The Effects of Chronic Kidney Disease on Antiviral T Cell Response.
Volume: 19 Page(s): 1047 - 1047
04/01/2019 Authors: Crepeau RL; Li H; Daley-Bauer LP; Ford ML; Winterberg PD -
Memory T Follicular Helper Cell Alloresponse is Memory B Cell Independent and Inhibited by CD28 Costimulation Blockade.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 19 Page(s): 566 - 567
04/01/2019 Authors: Zeng S; La Muraglia GM; Ford ML; Badell IR -
T Cells Play a Causal Role in Diastolic Dysfunction during Uremic Cardiomyopathy.
J Am Soc Nephrol Volume: 30 Page(s): 407 - 420
03/01/2019 Authors: Winterberg PD; Robertson JM; Kelleman MS; George RP; Ford ML -
Sepsis erodes CD8+ memory Tcell-protective immunity against an EBV homolog in a 2B4-dependent manner.
Volume: 105 Page(s): 565 - 575
03/01/2019 Authors: Xie J; Crepeau RL; Chen C-W; Zhang W; Otani S; Coopersmith CM; Ford ML -
Coronin-1, King of Alloimmunity.
Immunity Volume: 50 Page(s): 3 - 5
01/15/2019 Authors: Ford ML -
IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis.
Front Immunol Volume: 10 Page(s): 1982
01/01/2019 Authors: Morrow KN; Coopersmith CM; Ford ML -
Regulators of Intestinal Epithelial Migration in Sepsis.
Shock Volume: 51 Page(s): 88 - 96
01/01/2019 Authors: Meng M; Klingensmith NJ; Liang Z; Lyons JD; Fay KT; Chen C-W; Ford ML; Coopersmith CM -
Transplantation preferentially induces a KLRG-1lo CD127hi differentiation program in antigen-specific CD8+ T cells.
Transpl Immunol Volume: 50 Page(s): 34 - 42
10/01/2018 Authors: Bozeman AM; Laurie SJ; Haridas D; Wagener ME; Ford ML -
2B4 Mediates Inhibition of CD8+ T Cell Responses via Attenuation of Glycolysis and Cell Division.
J Immunol Volume: 201 Page(s): 1536 - 1548
09/01/2018 Authors: Laurie SJ; Liu D; Wagener ME; Stark PC; Terhorst C; Ford ML -
The small heat shock protein HSPB1 protects mice from sepsis.
Sci Rep Volume: 8 Page(s): 12493
08/21/2018 Authors: Breed ER; Hilliard CA; Yoseph B; Mittal R; Liang Z; Chen C-W; Burd EM; Brewster LP; Hansen LM; Gleason RL -
Type I IFN signaling blockade by a PASylated antagonist during chronic SIV infection suppresses specific inflammatory pathways but does not alter T cell activation or virus replication.
PLoS Pathog Volume: 14 Page(s): e1007246
08/01/2018 Authors: Nganou-Makamdop K; Billingsley JM; Yaffe Z; O'Connor G; Tharp GK; Ransier A; Laboune F; Matus-Nicodemos R; Lerner A; Gharu L -
Honokiol Increases CD4+ T Cell Activation and Decreases TNF but Fails to Improve Survival Following Sepsis.
Shock Volume: 50 Page(s): 178 - 186
08/01/2018 Authors: Klingensmith NJ; Chen C-W; Liang Z; Burd EM; Farris AB; Arbiser JL; Ford ML; Coopersmith CM -
Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.
Am J Transplant Volume: 18 Page(s): 1604 - 1614
07/01/2018 Authors: Tambur AR; Campbell P; Claas FH; Feng S; Gebel HM; Jackson AM; Mannon RB; Reed EF; Tinckam K; Askar M -
RIP3 KINASE INHIBITION WORSENS MORTALITY IN SEPSIS BY INDUCING CELLULAR APOPTOSIS, AN EFFECT WHICH IS REVERSED FOLLOWING TNF BLOCKADE
Volume: 49 Page(s): 67 - 67
06/01/2018 Authors: Fitzgerald CA; Lyons JD; Otani S; Mandal P; Ford ML; Mocarski EW; Coopersmith CM -
SEPSIS DIFFERENTIALLY IMPACTS TUMOR-SPECIFIC VS. BYSTANDER T CELLS IN MICE WITH PRE-EXISTING MALIGNANCY
Volume: 49 Page(s): 21 - 21
06/01/2018 Authors: Chen C-W; Coopersmith C; Ford M -
TIGIT MODULATES SEPSIS-INDUCED DYSREGULATION IN HOSTS WITH PRE-EXISTING MALIGNANCY
Volume: 49 Page(s): 20 - 21
06/01/2018 Authors: Zhang W; Ramonell K; Chen C-W; Liang Z; Chihade DB; Otani S; Coopersmith CM; Ford ML -
Circulating T Follicular Helper Cells Expand Following Transplantation and Exhibit a CD44(hi) Phenotype That Correlates with Peak Germinal Center Alloreactivity.
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 18 Page(s): 891 - 891
06/01/2018 Authors: La Muraglia G; Wagener M; Ford M; Badell R -
Phase II trial of pembrolizumab (MK-3475) in metastatic cutaneous squamous cell carcinoma (cSCC)
Volume: 36
05/20/2018 Authors: Kudchadkar RR; Yushak ML; Lawson DH; Delman KA; Lowe MC; Goings M; McBrien S; Mckellar M; Sieja K; Maynard N -
Selective CD28 blockade attenuates CTLA-4-dependent CD8+ memory T cell effector function and prolongs graft survival.
JCI Insight Volume: 3
01/11/2018 Authors: Liu D; Badell IR; Ford ML -
Selective CD28 Blockade Results in Superior Inhibition of Donor-Specific T Follicular Helper Cell and Antibody Responses Relative to CTLA4-Ig.
Am J Transplant Volume: 18 Page(s): 89 - 101
01/01/2018 Authors: Badell IR; La Muraglia GM; Liu D; Wagener ME; Ding G; Ford ML -
The outstanding questions in transplantation: It's about time.
Am J Transplant Volume: 18 Page(s): 271 - 272
01/01/2018 Authors: Azzi J; Raimondi G; Mas V; Riella LV; Elfadawy N; Safa K; Wojciechowski D; Kanak M; Nog R; Maltzman JS -
Pre-existing malignancy results in increased prevalence of distinct populations of CD4+ T cells during sepsis.
PLoS One Volume: 13 Page(s): e0191065
01/01/2018 Authors: Xie J; Robertson JM; Chen C-W; Zhang W; Coopersmith CM; Ford ML -
Influence of T Cell Coinhibitory Molecules on CD8+ Recall Responses.
Front Immunol Volume: 9 Page(s): 1810
01/01/2018 Authors: Morris AB; Adams LE; Ford ML -
Increased mortality in CD43-deficient mice during sepsis.
PLoS One Volume: 13 Page(s): e0202656
01/01/2018 Authors: Fay KT; Chihade DB; Chen C-W; Klingensmith NJ; Lyons JD; Ramonell K; Liang Z; Coopersmith CM; Ford ML -
Sepsis reveals compartment-specific responses in intestinal proliferation and apoptosis in transgenic mice whose enterocytes re-enter the cell cycle.
FASEB J Volume: 31 Page(s): 5507 - 5519
12/01/2017 Authors: Lyons JD; Klingensmith NJ; Otani S; Mittal R; Liang Z; Ford ML; Coopersmith CM -
The intestinal microenvironment in sepsis.
Biochim Biophys Acta Mol Basis Dis Volume: 1863 Page(s): 2574 - 2583
10/01/2017 Authors: Fay KT; Ford ML; Coopersmith CM -
Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis.
J Immunol Volume: 199 Page(s): 1961 - 1966
09/15/2017 Authors: Chen C-W; Mittal R; Klingensmith NJ; Burd EM; Terhorst C; Martin GS; Coopersmith CM; Ford ML -
Increased Pretransplant Frequency of CD28+ CD4+ TEM Predicts Belatacept-Resistant Rejection in Human Renal Transplant Recipients.
Am J Transplant Volume: 17 Page(s): 2350 - 2362
09/01/2017 Authors: Cortes-Cerisuelo M; Laurie SJ; Mathews DV; Winterberg PD; Larsen CP; Adams AB; Ford ML -
Belatacept-Resistant Rejection Is Associated With CD28+ Memory CD8 T Cells.
Am J Transplant Volume: 17 Page(s): 2285 - 2299
09/01/2017 Authors: Mathews DV; Wakwe WC; Kim SC; Lowe MC; Breeden C; Roberts ME; Farris AB; Strobert EA; Jenkins JB; Larsen CP -
CD28 directed immunotherapy is more potent than belatacept in a pig-to-nonhuman primate renal xenotransplant model
Volume: 24
09/01/2017 Authors: Kim S; Higginbotham L; Mathews DV; Breeden C; Stephenson A; Larsen CP; Ford M; Tector J; Adams AB -
CD4 depletion is necessary and sufficient for long-term pig-to-nonhuman primate renal xenotransplant survival
Volume: 24
09/01/2017 Authors: Kim S; Higginbotham LB; Mathews DV; Breeden C; Dong Y; Stephenson A; Larsen CP; Ford M; Tector J; Adams AB -
Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity.
Expert Opin Biol Ther Volume: 17 Page(s): 1001 - 1012
08/01/2017 Authors: Crepeau RL; Ford ML -
Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis.
Mol Med Volume: 23 Page(s): 155 - 165
08/01/2017 Authors: Lorentz CA; Liang Z; Meng M; Chen C-W; Yoseph BP; Breed ER; Mittal R; Klingensmith NJ; Farris AB; Burd EM -
Alloimmunity But Not Viral Immunity Promotes Allograft Loss in a Mouse Model of Polyomavirus-Associated Allograft Injury.
Transplant Direct Volume: 3 Page(s): e161
06/01/2017 Authors: Kim SC; Wang J; Dong Y; Mathews DV; Albrecht JA; Breeden CP; Farris AB; Lukacher AE; Ford ML; Newell KA -
HONOKIOL TREATMENT INCREASES DENDRITIC CELLS AND ACTIVATED CD4+T CELLS IN MURINE POLYMICROBIAL SEPSIS
Volume: 47 Page(s): 63 - 63
06/01/2017 Authors: Liang Z; Klingensmith N; Chen C-W; Burd E; Farris A; Arbiser J; Ford M; Coopersmith C -
EPIDERMAL GROWTH FACTOR PARADOXICALLY WORSENS SURVIVAL DURING PERITONEAL SEPSIS IN THE SETTING OF PRE-EXISTING MALIGNANCY
Volume: 47 Page(s): 34 - +
06/01/2017 Authors: Fitzgerald CA; Fay KT; Chen C-W; Ramonell KM; Liang Z; Klingensmith NJ; Coopersmith CM; Ford ML -
IMPROVED SURVIVAL IN SEPTIC JAM-A-/- MICE AND INTESTINAL MICROBIOME-IMMUNE INTERACTION
Volume: 47 Page(s): 21 - 22
06/01/2017 Authors: Klingensmith NJ; Fay KT; Chen C-W; Lyons JD; Burd E; Liang Z; Ford ML; Coopersmith CM -
PRE-EXISTING MALIGNANCY INCREASES THE CO-EXPRESSION OF TIGIT AND PD-1 ON ACTIVATED CD44(HI) CD4(+) T CELLS IN SEPTIC MICE
Volume: 47 Page(s): 19 - 20
06/01/2017 Authors: Ramonell KM; Chen C-W; Fay KT; Klingensmith NJ; Lyons JD; Liang Z; Coopersmith CM; Ford ML -
INCREASED EFFICACY OF ANTI-CTLA-4 IN DECREASING SEPSIS MORTALITY IN CHRONIC ETHANOL EXPOSED MICE RELATIVE TO NON-CHRONIC ETHANOL EXPOSED MICE
Volume: 47 Page(s): 130 - 131
06/01/2017 Authors: Fay KT; Chen C-W; Klingensmith N; Liang Z; Coopersmith C; Ford ML -
BLOCKADE OF 2B4 BUT NOT PD-1 MEDIATES DECREASED SEPSIS MORTALITY IN ANIMALS WITH PREEXISTING MALIGNANCY
Volume: 47 Page(s): 12 - 13
06/01/2017 Authors: Chen C-W; Klingensmith N; Liang Z; Coopersmith C; Ford M -
Fc-Silent Anti-CD154 Domain Antibody Effectively Prevents Nonhuman Primate Renal Allograft Rejection.
Am J Transplant Volume: 17 Page(s): 1182 - 1192
05/01/2017 Authors: Kim SC; Wakwe W; Higginbotham LB; Mathews DV; Breeden CP; Stephenson AC; Jenkins J; Strobert E; Price K; Price L -
Epigenetic Remodeling in Exhausted T Cells: Implications for Transplantation Tolerance.
Transplantation Volume: 101 Page(s): 894 - 895
05/01/2017 Authors: Laurie SJ; Ford ML -
CD28 Directed Immunotherapy Is More Potent Than Belatacept in a Nonhuman Primate Xenotransplant Model
Volume: 17 Page(s): 374 - 375
04/01/2017 Authors: Kim S; Higginbotham L; Mathews D; Breeden C; Stephenson A; Larsen C; Ford M; Tector J; Adams A -
FcgRIIB-Mediated Coinhibition Attenuates Donor-Reactive CD8+T Cell Responses
Volume: 17 Page(s): 365 - 365
04/01/2017 Authors: Morris A; Pinelli D; Liu D; Ford M -
Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity
Volume: 17 Page(s): 275 - 275
04/01/2017 Authors: Crepeau R; Liu D; Ford M -
CD4 Depletion Is Necessary and Sufficient for Long-Term Nonhuman Primate Xenotransplant Survival
Volume: 17 Page(s): 374 - 374
04/01/2017 Authors: Kim S; Higginbotham L; Mathews D; Breeden C; Stephenson A; Larsen C; Ford M; Tector J; Adams A -
T-FR:T-FH Cell Ratio Correlates with Anti-Donor Germinal Center Reactivity and Donor-Specific Antibody Formation Following Transplantation
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 17 Page(s): 275 - 275
04/01/2017 Authors: La Muraglia G; Ford M; Badell I -
2B4-Mediated Inhibition of Proliferation and Glycolytic Function Attenuates T Cell Alloreactivity
Volume: 17 Page(s): 272 - 272
04/01/2017 Authors: Laurie S; Liu D; Cortes M; Wagener M; Ford M -
High CTLA-4 Expression and Diminished FOXO3 Expression Underlie Differential CD28 Signaling on Human Memory Th17 Cells
Volume: 17 Page(s): 272 - 272
04/01/2017 Authors: Krummey S; Suchard S; Nadler S; Larsen C; Ford M -
Interruption of OX40L signaling prevents costimulation blockade-resistant allograft rejection.
JCI Insight Volume: 2 Page(s): e90317
03/09/2017 Authors: Kitchens WH; Dong Y; Mathews DV; Breeden CP; Strobert E; Fuentes ME; Larsen CP; Ford ML; Adams AB -
Age-Associated B Cells Express a Diverse Repertoire of VH and V Genes with Somatic Hypermutation.
J Immunol Volume: 198 Page(s): 1921 - 1927
03/01/2017 Authors: Russell Knode LM; Naradikian MS; Myles A; Scholz JL; Hao Y; Liu D; Ford ML; Tobias JW; Cancro MP; Gearhart PJ -
The effect of chronic kidney disease on T cell alloimmunity.
Curr Opin Organ Transplant Volume: 22 Page(s): 22 - 28
02/01/2017 Authors: Winterberg PD; Ford ML -
Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion.
Shock Volume: 47 Page(s): 184 - 192
02/01/2017 Authors: Klingensmith NJ; Yoseph BP; Liang Z; Lyons JD; Burd EM; Margoles LM; Koval M; Ford ML; Coopersmith CM -
2B4-SAP signaling is required for the priming of naive CD8+ T cells by antigen-expressing B cells and B lymphoma cells.
Oncoimmunology Volume: 6 Page(s): e1267094
01/01/2017 Authors: Huang Y-H; Tsai K; Tan SY; Kang S; Ford ML; Harder KW; Priatel JJ -
CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis.
PLoS One Volume: 12 Page(s): e0188882
01/01/2017 Authors: Ramonell KM; Zhang W; Hadley A; Chen C-W; Fay KT; Lyons JD; Klingensmith NJ; McConnell KW; Coopersmith CM; Ford ML -
Commentary: Belatacept Does Not Inhibit Follicular T Cell-Dependent B-Cell Differentiation in Kidney Transplantation.
Front Immunol Volume: 8 Page(s): 1615
01/01/2017 Authors: Schroder PM; Ezekian B; Ford M; Knechtle SJ; Kwun J -
Attrition of memory CD8 T cells during sepsis requires LFA-1.
J Leukoc Biol Volume: 100 Page(s): 1167 - 1180
11/01/2016 Authors: Serbanescu MA; Ramonell KM; Hadley A; Margoles LM; Mittal R; Lyons JD; Liang Z; Coopersmith CM; Ford ML; McConnell KW -
Complete response to high-dose IL-2 and enhanced IFN+Th17: TREG ratio in a melanoma patient.
Melanoma Res Volume: 26 Page(s): 535 - 539
10/01/2016 Authors: Diller ML; Kudchadkar RR; Delman KA; Lawson DH; Ford ML -
Costimulation Blockade in Autoimmunity and Transplantation: The CD28 Pathway.
J Immunol Volume: 197 Page(s): 2045 - 2050
09/15/2016 Authors: Adams AB; Ford ML; Larsen CP -
Enhanced Requirement for TNFR2 in Graft Rejection Mediated by Low-Affinity Memory CD8+ T Cells during Heterologous Immunity.
J Immunol Volume: 197 Page(s): 2009 - 2015
09/01/2016 Authors: Krummey SM; Chen C-W; Guasch SA; Liu D; Wagener M; Larsen CP; Ford ML -
Of (Dirty) Mice, Men and Memory.
Am J Transplant Volume: 16 Page(s): 2243
08/01/2016 Authors: Ford ML -
Mechanisms of Intestinal Barrier Dysfunction in Sepsis.
Shock Volume: 46 Page(s): 52 - 59
07/01/2016 Authors: Yoseph BP; Klingensmith NJ; Liang Z; Breed ER; Burd EM; Mittal R; Dominguez JA; Petrie B; Ford ML; Coopersmith CM -
Micromanaging alloimmunity.
J Clin Invest Volume: 126 Page(s): 2422 - 2424
07/01/2016 Authors: Ford ML -
Tregs Hold On To Ceramide.
Am J Transplant Volume: 16 Page(s): 1945
07/01/2016 Authors: Krummey SM; Ford ML -
2B4-MEDIATED COINHIBITION OF CD4 T CELLS CONTRIBUTES TO MORTALITY IN SEPSIS
Volume: 45 Page(s): 61 - 62
06/01/2016 Authors: Chen C; Klingensmith N; Lyons JD; Liang Z; Coopersmith C; Ford M -
SYSTEMIC EGF ADMINISTRATION IN A MURINE MODEL OF SEPTIC PERITONITIS AND CHRONIC ETHANOL EXPOSURE REDUCES CELLULAR APOPTOSIS IN CD4+T CELL SUBSETS
Volume: 45 Page(s): 138 - 139
06/01/2016 Authors: Fay K; Klingensmith N; Coopersmith C; Ford M -
The Microbiome in Critical Illness: Firm Conclusions or Bact to Square One?
Dig Dis Sci Volume: 61 Page(s): 1420 - 1421
06/01/2016 Authors: Lyons JD; Ford ML; Coopersmith CM -
Late Renal Xenograft Failure Is Antibody-Mediated: Description of the Longest-Reported Survival in Pig-to-Primate Renal Xenotransplantation
Volume: 16 Page(s): 406 - 406
06/01/2016 Authors: Higginbotham L; Kim S; Mathews D; Stephenson A; Breeden C; Larsen C; Ford M; Newell K; Tector A; Adams A -
2B4 Over-Expression Impairs Donor-Reactive CD8+T Cell Proliferation and Accumulation Following Transplantation.
Volume: 16 Page(s): 392 - 393
06/01/2016 Authors: Laurie S; Liu D; Ford M -
Rapid Emergence of CD28(null) Cells Following Ex Vivo Restimulation Is Associated with Belatacept Resistant Rejection.
Volume: 16 Page(s): 452 - 452
06/01/2016 Authors: Cortes M; Laurie S; Sayed B; Ford M -
Inhibitory FcgRIIB Functionally Inhibits Donor-Reactive CD8(+) Memory T Cell Responses Following Transplantation
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 16 Page(s): 325 - 326
06/01/2016 Authors: Pinelli D; Wagener M; Liu D; Badell I; Ford M -
Profiling Metabolic Differences Between Graft- vs. Pathogen-Elicited CD8(+) T Cell Responses
Volume: 16 Page(s): 367 - 367
06/01/2016 Authors: Karp A; Wagener M; Robertson J; Ford M -
Sepsis Prolongs Allograft Survival Compared with Non-Septic Infection in a Murine Model of Skin Transplantation and Pseudomonas aeruginosa Pneumonia.
Volume: 16 Page(s): 506 - 506
06/01/2016 Authors: Margoles L; Laurie S; Coopersmith C; Ford M -
CTLA4 Negatively Regulates Donor-Reactive CXCR5+PD1+T Follicular Helper Cell Responses Following Transplantation
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 16 Page(s): 368 - 368
06/01/2016 Authors: Badell I; Liu D; Suchard S; Nadler S; Ford M -
T Cell Cosignaling Molecules in Transplantation.
Immunity Volume: 44 Page(s): 1020 - 1033
05/17/2016 Authors: Ford ML -
SLAM family receptors 2B4 and CD48 are key drivers of CD8 T cell priming by B cells
Volume: 196
05/01/2016 Authors: Huang Y-H; Tsai K; Kang S; Wang X; Ford ML; Harder KW; Tan R; Priatel JJ -
Virally-Induced Heterologous Immunity in Renal Transplant Recipients: Important or Inconsequential?
Am J Transplant Volume: 16 Page(s): 1348 - 1349
05/01/2016 Authors: Ford ML -
Low-Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity.
J Immunol Volume: 196 Page(s): 2838 - 2846
03/15/2016 Authors: Krummey SM; Martinez RJ; Andargachew R; Liu D; Wagener M; Kohlmeier JE; Evavold BD; Larsen CP; Ford ML -
T follicular helper cells in the generation of alloantibody and graft rejection.
Curr Opin Organ Transplant Volume: 21 Page(s): 1 - 6
02/01/2016 Authors: Badell IR; Ford ML -
Retrogenic ICOS Expression Increases Differentiation of KLRG-1hiCD127loCD8+ T Cells during Listeria Infection and Diminishes Recall Responses.
J Immunol Volume: 196 Page(s): 1000 - 1012
02/01/2016 Authors: Liu D; Burd EM; Coopersmith CM; Ford ML -
Chronic Alcohol Ingestion Delays T Cell Activation and Effector Function in Sepsis.
PLoS One Volume: 11 Page(s): e0165886
01/01/2016 Authors: Margoles LM; Mittal R; Klingensmith NJ; Lyons JD; Liang Z; Serbanescu MA; Wagener ME; Coopersmith CM; Ford ML -
Exogenous IL-2 Induces FoxP3+ Th17 Cells In Vivo in Melanoma Patients.
J Immunother Volume: 39 Page(s): 355 - 366
01/01/2016 Authors: Diller ML; Kudchadkar RR; Delman KA; Lawson DH; Ford ML -
Balancing Inflammation: The Link between Th17 and Regulatory T Cells.
Mediators Inflamm Volume: 2016 Page(s): 6309219
01/01/2016 Authors: Diller ML; Kudchadkar RR; Delman KA; Lawson DH; Ford ML -
Murine Lung Cancer Increases CD4+ T Cell Apoptosis and Decreases Gut Proliferative Capacity in Sepsis.
PLoS One Volume: 11 Page(s): e0149069
01/01/2016 Authors: Lyons JD; Mittal R; Fay KT; Chen C-W; Liang Z; Margoles LM; Burd EM; Farris AB; Ford ML; Coopersmith CM -
Pathogen Stimulation History Impacts Donor-Specific CD8(+) T Cell Susceptibility to Costimulation/Integrin Blockade-Based Therapy.
Am J Transplant Volume: 15 Page(s): 3081 - 3094
12/01/2015 Authors: Badell IR; Kitchens WH; Wagener ME; Lukacher AE; Larsen CP; Ford ML -
LONG-TERM SURVIVAL OF PIG-TO-PRIMATE RENAL XENOTRANSPLANT USING COSTIMULATION-BLOCKADE IMMUNOSUPPRESSION.
Volume: 99 Page(s): S72 - S73
11/01/2015 Authors: Higginbotham L; Mathews D; Stephenson A; Breeden C; Larsen CP; Ford ML; Newell KA; Tector J; Adams AB -
Long-term survival of pig-to-primate renal xenotransplant using costimulation-blockade immunosuppression
Volume: 22 Page(s): S45 - S45
11/01/2015 Authors: Higginbotham L; Mathews D; Stephenson A; Breeden C; Larsen CP; Ford ML; Newell KA; Tector J; Adams AB -
Preventing T cell rejection of pig xenografts.
Int J Surg Volume: 23 Page(s): 285 - 290
11/01/2015 Authors: Higginbotham L; Ford ML; Newell KA; Adams AB -
Literature Watch Implications for transplantation.
Am J Transplant Volume: 15 Page(s): 2535
10/01/2015 Authors: Ford ML -
Rapamycin ameliorates the CTLA4-Ig-mediated defect in CD8(+) T cell immunity during gammaherpesvirus infection.
Am J Transplant Volume: 15 Page(s): 2576 - 2587
10/01/2015 Authors: Pinelli DF; Wakeman BS; Wagener ME; Speck SH; Ford ML -
Literature Watch Implications for transplantation.
Am J Transplant Volume: 15 Page(s): 2281
09/01/2015 Authors: Ford ML -
High dose IL-2 (HDIL-2) results in increased PD-1 expression on CD45RA-CCR7-CD8+and CD45RA-CCR7-CD4+T cells in melanoma patients
Volume: 75
08/01/2015 Authors: Diller ML; Maio S; Eysmans GE; Lawson D; Delman KA; Kudchadkar RR; Ford ML -
Literature Watch Implications for transplantation.
Am J Transplant Volume: 15 Page(s): 1739
07/01/2015 Authors: Ford ML -
CHRONIC ALCOHOL INGESTION DELAYS MEMORY CD8+T CELL ACTIVATION AND EFFECTOR FUNCTION IN SEPSIS
Volume: 43 Page(s): 87 - 87
06/01/2015 Authors: Margoles L; Liang Z; Lyons J; Mittal R; Coopersmith CM; Ford ML -
THE KINETICS AND FUNCTIONAL ROLE OF 2B4 EXPRESSION ON CD8+T CELLS DURING SEPSIS
Volume: 43 Page(s): 89 - 89
06/01/2015 Authors: Chen C; Lyons J; Liang Z; Coopersmith CM; Ford ML -
Literature Watch Implications for transplantation.
Am J Transplant Volume: 15 Page(s): 1451
06/01/2015 Authors: Ford ML -
Analysis of CTLA4 expression on T regulatory cells in patients with advanced stage melanoma in the setting of high dose IL-2 (HDIL-2)
Volume: 33
05/20/2015 Authors: Diller ML; Eysmans CE; Lawson DH; Delman KA; Kudchadkar RR; Ford M -
Murine lung cancer induces generalized T-cell exhaustion.
J Surg Res Volume: 195 Page(s): 541 - 549
05/15/2015 Authors: Mittal R; Chen C-W; Lyons JD; Margoles LM; Liang Z; Coopersmith CM; Ford ML -
Overexpression of 2B4 Inhibits the Expansion and Function of Donor-Reactive CD8+T Cells in Selective Lymphoid Compartments
Volume: 15
05/01/2015 Authors: Laurie S; Liu D; Ford M -
Enhanced Requirement for TNF Signaling on Low Affinity Memory CD8+T Cells During Heterologous Immunity
Volume: 15
05/01/2015 Authors: Krummey S; Chen C-W; Liu D; Wagener M; Evavold B; Larsen C; Ford M -
Literature Watch Implications for transplantation.
Am J Transplant Volume: 15 Page(s): 577
03/01/2015 Authors: Iwakoshi NN; Ford ML -
New insights into T-cell cosignaling in allograft rejection and survival.
Curr Opin Organ Transplant Volume: 20 Page(s): 43 - 48
02/01/2015 Authors: Krummey SM; Ford ML -
Pre-transplant antibody screening and anti-CD154 costimulation blockade promote long-term xenograft survival in a pig-to-primate kidney transplant model.
Xenotransplantation Volume: 22 Page(s): 221 - 230
01/01/2015 Authors: Higginbotham L; Mathews D; Breeden CA; Song M; Farris AB; Larsen CP; Ford ML; Lutz AJ; Tector M; Newell KA -
Novel insights into anti-CD40/CD154 immunotherapy in transplant tolerance.
Immunotherapy Volume: 7 Page(s): 399 - 410
01/01/2015 Authors: Pinelli DF; Ford ML -
Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/4GalNT2 genes.
Xenotransplantation Volume: 22 Page(s): 194 - 202
01/01/2015 Authors: Estrada JL; Martens G; Li P; Adams A; Newell KA; Ford ML; Butler JR; Sidner R; Tector M; Tector J -
Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.
PLoS One Volume: 10 Page(s): e0130490
01/01/2015 Authors: Liu D; Suchard SJ; Nadler SG; Ford ML -
Literature Watch Implications for transplantation.
Am J Transplant Volume: 15 Page(s): 3
01/01/2015 Authors: Tector AJ; Ford ML -
CHRONIC ALCOHOL INGESTION AFFECTS CD4 T CELL FUNCTION BUT NOT ACTIVATION IN SEPSIS
CRITICAL CARE MEDICINE Volume: 42
12/01/2014 Authors: Margoles L; Mittal R; Serbanescu M; Liang Z; Lyons J; Ford M; Coopersmith C -
Literature Watch Implications for transplantation.
Am J Transplant Volume: 14 Page(s): 2677
12/01/2014 Authors: Martinez OM; Ford ML -
Braking bad: novel mechanisms of CTLA-4 inhibition of T cell responses.
Am J Transplant Volume: 14 Page(s): 2685 - 2690
12/01/2014 Authors: Krummey SM; Ford ML -
Getting older can be exhausting.
Crit Care Volume: 18 Page(s): 465
07/29/2014 Authors: Mittal R; Ford ML; Coopersmith CM -
Rapamycin Rescues CTLA4-Ig-Mediated Impairment of CD8 T Cell Responses to a Gammaherpesvirus Infection.
Volume: 98 Page(s): 35 - 35
07/15/2014 Authors: Pinelli D; Ford M -
Selective CD28 Blockade Exhibits Superior Suppression of Donor-Specific Antibody Relative to CTLA4Ig.
Volume: 98 Page(s): 36 - 36
07/15/2014 Authors: Badell I; Liu D; Suchard S; Nadler S; Ford M -
Foxp3+Alloantigen-Specific iTreg Highly Express CTLA4 and Preferentially Survive Following CTLA4-Ig Treatment.
Volume: 98 Page(s): 24 - 24
07/15/2014 Authors: Pinelli D; Nadler S; Ford M -
2B4 (CD244) Induced By Selective CD28 Blockade Functionally Regulates Allograft-Specific CD8(+) T Cell Responses.
Volume: 98 Page(s): 322 - 322
07/15/2014 Authors: Liu D; Krummey S; Badell I; Wagener M; Schneeweis L; Stetsko D; Suchard S; Nadler S; Ford M -
Low Affinity CD8(+) CD45RB(high) TNF-Producing T-CM Are Potently Alloreactive Against High Affinity Antigen in a Model of T Cell Receptor Cross-Reactive Heterologous Immunity
Volume: 98 Page(s): 33 - 33
07/15/2014 Authors: Krummey S; Martinez R; Liu D; Wagener M; Kohlmeier J; Evavold B; Larsen C; Ford M -
Investigating The Functional Role of CD28 On Belatacept-Resistant Human TH17 Memory Cells.
Volume: 98 Page(s): 312 - 312
07/15/2014 Authors: Krummey S; Gaville C; Cheeseman J; Conger J; Jang P; Suchard S; Boise L; Nadler S; Kirk A; Larsen C -
2B4 (CD244) Induced By Selective CD28 Blockade Functionally Regulates Allograft-Specific CD8(+) T Cell Responses
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 14 Page(s): 322 - 322
06/01/2014 Authors: Liu D; Krummey S; Badell I; Wagener M; Schneeweis L; Stetsko D; Suchard S; Nadler S; Ford M -
Rapamycin Rescues CTLA4-Ig-Mediated Impairment of CD8 T Cell Responses to a Gammaherpesvirus Infection.
Volume: 14 Page(s): 35 - 35
06/01/2014 Authors: Pinelli D; Ford M -
Selective CD28 Blockade Exhibits Superior Suppression of Donor-Specific Antibody Relative to CTLA4Ig
AMERICAN JOURNAL OF TRANSPLANTATION Volume: 14 Page(s): 36 - 36
06/01/2014 Authors: Badell I; Liu D; Suchard S; Nadler S; Ford M -
Foxp(3+) Alloantigen-Specific iTreg Highly Express CTLA4 and Preferentially Survive Following CTLA4-Ig Treatment.
Volume: 14 Page(s): 24 - 24
06/01/2014 Authors: Pinelli D; Nadler S; Ford M -
Investigating The Functional Role of CD28 On Belatacept-Resistant Human TH17 Memory Cells
Volume: 14 Page(s): 312 - 312
06/01/2014 Authors: Krummey S; Gaville C; Cheeseman J; Conger J; Jang P; Suchard S; Boise L; Nadler S; Kirk A; Larsen C -
Low Affinity CD8(+) CD45RB(high) TNF-Producing T-CM Are Potently Alloreactive Against High Affinity Antigen in a Model of T Cell Receptor Cross-Reactive Heterologous Immunity.
Volume: 14 Page(s): 33 - 33
06/01/2014 Authors: Krummey S; Martinez R; Liu D; Wagener M; Kohlmeier J; Evavold B; Larsen C; Ford M -
CHARACTERIZATION OF THE CD8 T CELL RESPONSE IN A MURINE MODEL OF SEPSIS
Volume: 41 Page(s): 42 - 42
06/01/2014 Authors: Serbanescu M; Hadley A; Margoles L; Mittal R; Lyons J; Ali Y; Ford ML; Coopersmith CM; McConnell K -
MURINE LUNG CANCER DECREASES SEPSIS SURVIVAL AND WORSENS SEPSIS-INDUCED IMMUNE COMPROMISE
Volume: 41 Page(s): 78 - 78
06/01/2014 Authors: Lyons J; Mittal R; Liang Z; Margoles L; Ford ML; Coopersmith CM -
2B4: A POTENTIAL TARGET FOR RESTORING IMMUNE COMPETENCE DURING SEPSIS
Volume: 41 Page(s): 29 - 29
06/01/2014 Authors: Mittal R; Wagener M; Liang Z; Lyons JD; Margoles L; Coopersmith CM; Ford ML -
CHRONIC ALCOHOL INGESTION AND T CELL CYTOKINE PRODUCTION IN SEPSIS
Volume: 41 Page(s): 72 - 73
06/01/2014 Authors: Margoles L; Mittal R; Lyons J; Liang Z; Serbanescu M; Ford ML; Coopersmith CM -
Candida-elicited murine Th17 cells express high Ctla-4 compared with Th1 cells and are resistant to costimulation blockade.
J Immunol Volume: 192 Page(s): 2495 - 2504
03/01/2014 Authors: Krummey SM; Floyd TL; Liu D; Wagener ME; Song M; Ford ML -
High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept.
Am J Transplant Volume: 14 Page(s): 607 - 614
03/01/2014 Authors: Krummey SM; Cheeseman JA; Conger JA; Jang PS; Mehta AK; Kirk AD; Larsen CP; Ford ML -
2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses.
J Exp Med Volume: 211 Page(s): 297 - 311
02/10/2014 Authors: Liu D; Krummey SM; Badell IR; Wagener M; Schneeweis LA; Stetsko DK; Suchard SJ; Nadler SG; Ford ML -
Targeting co-stimulatory pathways: transplantation and autoimmunity.
Nat Rev Nephrol Volume: 10 Page(s): 14 - 24
01/01/2014 Authors: Ford ML; Adams AB; Pearson TC -
Phenotypic T cell exhaustion in a murine model of bacterial infection in the setting of pre-existing malignancy.
PLoS One Volume: 9 Page(s): e93523
01/01/2014 Authors: Mittal R; Wagener M; Breed ER; Liang Z; Yoseph BP; Burd EM; Farris AB; Coopersmith CM; Ford ML -
The Spectrum of Alloimmunity, Heterologous Immunity, and Relevant Autoimmunity
Page(s): 87 - 98
01/01/2014 Authors: Ford ML; Adams AB; Larsen CP -
An anti-CD154 domain antibody prolongs graft survival and induces Foxp3(+) iTreg in the absence and presence of CTLA-4 Ig.
Am J Transplant Volume: 13 Page(s): 3021 - 3030
11/01/2013 Authors: Pinelli DF; Wagener ME; Liu D; Yamniuk A; Tamura J; Grant S; Larsen CP; Suri A; Nadler SG; Ford ML -
Necrosis and immune activation: does tissue death alter acquired alloimmunity?
Volume: 217 Page(s): S141 - S142
09/01/2013 Authors: Hashmi SS; Ford ML; Larsen CP; Kirk AD -
Inhibition of CD8+ T cell-derived CD40 signals is necessary but not sufficient for Foxp3+ induced regulatory T cell generation in vivo.
J Immunol Volume: 191 Page(s): 1957 - 1964
08/15/2013 Authors: Liu D; Ferrer IR; Konomos M; Ford ML -
PRE-EXISTING MALIGNANCY ALTERS INNATE AND ADAPTIVE IMMUNE RESPONSES IN A MURINE MODEL OF INFECTION
Volume: 39 Page(s): 46 - 46
06/01/2013 Authors: Mittal R; Wagener M; Breed ER; Liang Z; Yoseph BP; Coopersmith C; Ford M -
CHRONIC ALCOHOL CONSUMPTION INCREASES MORTALITY IN A MURINE MODEL OF SEPSIS AND ALTERS THE HOST IMMUNE RESPONSE
Volume: 39 Page(s): 106 - 107
06/01/2013 Authors: Yoseph BP; Liang Z; Breed ER; Mittal R; Wagener M; Ford M; Coopersmith C -
Low Affinity Memory CD8(+) T Cells Are Potently Alloreactive Against High Affinity Antigen in a Model of T Cell Receptor Cross-Reactive Heterologous Immunity
Volume: 13 Page(s): 143 - 143
04/01/2013 Authors: Krummey S; Larsen C; Ford M -
Combined Costimulatory and OX40L Blockade Significantly Prolongs Transplant Survival in Mice and Non-Human Primates
Volume: 13 Page(s): 50 - 50
04/01/2013 Authors: Kitchens W; Wakwe W; Breeden C; Yagita H; Kirk A; Larsen C; Fuentes M; Ford M; Adams A -
Cell Necrosis and Immune Activation: Does Injury Alter Acquired Alloimmunity?
Volume: 13 Page(s): 364 - 365
04/01/2013 Authors: Hashmi S; Ford M; Larsen C; Kirk A -
Th17 Memory Cells Are More Dependent on Coinhibition by CTLA-4 Than Th1 Memory Cells and Are Associated with Rejection in Patients Treated with Belatacept.
Volume: 13 Page(s): 252 - 252
04/01/2013 Authors: Krummey S; Cheeseman J; Jang P; Mehta A; Kirk A; Larsen C; Ford M -
Rapamycin-Induced Augmentation of the CD8 T Cell Response to a Latent Viral Infection Is Inhibited by CTLA4-Ig.
Volume: 13 Page(s): 180 - 180
04/01/2013 Authors: Pinelli D; Wagener M; Ford M -
Comparison of Efficacy and Mechanism of Intact and Fc-Modified Anti-CD154 Antibodies in Tolerance Induction.
Volume: 13 Page(s): 251 - 252
04/01/2013 Authors: Pinelli D; Liu D; Wagener M; Suri A; Nadler S; Ford M -
2B4 Induced by Selective CD28 Blockade Functionally Regulates Alloreactive Memory CD8+T Cell Responses
Volume: 13 Page(s): 143 - 143
04/01/2013 Authors: Liu D; Krummey S; Suchard S; Nadler S; Ford M -
Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis.
PLoS One Volume: 8 Page(s): e62792
01/01/2013 Authors: Yoseph BP; Breed E; Overgaard CE; Ward CJ; Liang Z; Wagener ME; Lexcen DR; Lusczek ER; Beilman GJ; Burd EM -
CCR6(+) Memory Th17 Cells Preferentially Express CTLA-4 and Are Resistant to Costimulation Blockade
TRANSPLANTATION Volume: 94 Page(s): 337 - 337
11/27/2012 Authors: Krummey SM; Floyd TL; Mehta AK; Ford ML -
CD40/CD154 blockade inhibits dendritic cell expression of inflammatory cytokines but not costimulatory molecules.
J Immunol Volume: 189 Page(s): 4387 - 4395
11/01/2012 Authors: Ferrer IR; Liu D; Pinelli DF; Koehn BH; Stempora LL; Ford ML -
CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
Am J Transplant Volume: 12 Page(s): 1918 - 1923
07/01/2012 Authors: Badell IR; Russell MC; Cardona K; Shaffer VO; Turner AP; Avila JG; Cano JA; Leopardi FV; Song M; Strobert EA -
Memory T cells: new insights into the molecular basis of sensitivity and heterogeneity.
Am J Transplant Volume: 12 Page(s): 1361
06/01/2012 Authors: Ford ML; Bromberg JS -
Combined costimulatory and leukocyte functional antigen-1 blockade prevents transplant rejection mediated by heterologous immune memory alloresponses.
Transplantation Volume: 93 Page(s): 997 - 1005
05/27/2012 Authors: Kitchens WH; Haridas D; Wagener ME; Song M; Ford ML -
Combined LFA-1 and Costimulatory Blockade Prevents Transplant Rejection Mediated by Heterologous Immune Memory Alloresponses
Volume: 12 Page(s): 39 - 39
05/01/2012 Authors: Kitchens WH; Haridas D; Wagener ME; Ford ML -
Secondary Lymphoid Organs Are Required for Rapamycin-Induced Augmentation of Pathogen-Specific CD8(+) Memory T Cell Responses
Volume: 12 Page(s): 459 - 459
05/01/2012 Authors: Ferrer IR; Wagener ME; Araki K; Ford ML -
CD40 Expressed by Donor-Reactive CD8+T Cells Prevents Foxp3+iTreg Conversion Following Transplantation.
Volume: 12 Page(s): 137 - 137
05/01/2012 Authors: Liu D; Ferrer IR; Larsen CP; Ford ML -
Anti-IL12/23 Synergizes with Costimulatory Blockade To Suppress Intragraft IL-17 and Prolong Transplant Survival in Mice and Non-Human Primates
Volume: 12 Page(s): 161 - 162
05/01/2012 Authors: Kitchens WH; Kirk AD; Larsen CP; Ford ML; Adams AB -
CTLA-4 Is Preferentially Expressed on Human IL-17 Producing CD4+CCR6+Memory Th17 T Cells Relative to IFN-gamma Producing Th1 Cells
Volume: 12 Page(s): 144 - 144
05/01/2012 Authors: Krummey SM; Floyd TL; Mehta AK; Ford ML -
MHC class Ib-restricted CD8 T cells differ in dependence on CD4 T cell help and CD28 costimulation over the course of mouse polyomavirus infection.
J Immunol Volume: 188 Page(s): 3071 - 3079
04/01/2012 Authors: Hofstetter AR; Ford ML; Sullivan LC; Wilson JJ; Hadley A; Brooks AG; Lukacher AE -
Syndecan-1 displays a protective role in aortic aneurysm formation by modulating T cell-mediated responses.
Arterioscler Thromb Vasc Biol Volume: 32 Page(s): 386 - 396
02/01/2012 Authors: Xiao J; Angsana J; Wen J; Smith SV; Park PW; Ford ML; Haller CA; Chaikof EL -
HEAVY WATER MITIGATES SURVIVAL IN SEPTIC MICE
Volume: 37 Page(s): 62 - 62
01/01/2012 Authors: Breed ER; Liang Z; Wagener ME; Yoseph BP; Ferrer IR; Ford ML; Buchman TG; Coopersmith CM -
Integrin antagonists prevent costimulatory blockade-resistant transplant rejection by CD8(+) memory T cells.
Am J Transplant Volume: 12 Page(s): 69 - 80
01/01/2012 Authors: Kitchens WH; Haridas D; Wagener ME; Song M; Kirk AD; Larsen CP; Ford ML -
Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.
Am J Transplant Volume: 12 Page(s): 126 - 135
01/01/2012 Authors: Badell IR; Thompson PW; Turner AP; Russell MC; Avila JG; Cano JA; Robertson JM; Leopardi FV; Strobert EA; Iwakoshi NN -
Heterogeneity within T Cell Memory: Implications for Transplant Tolerance.
Front Immunol Volume: 3 Page(s): 36
01/01/2012 Authors: Krummey SM; Ford ML -
CD154 blockade alters innate immune cell recruitment and programs alloreactive CD8+ T cells into KLRG-1(high) short-lived effector T cells.
PLoS One Volume: 7 Page(s): e40559
01/01/2012 Authors: Ferrer IR; Wagener ME; Song M; Ford ML -
Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade.
Proc Natl Acad Sci U S A Volume: 108 Page(s): 20701 - 20706
12/20/2011 Authors: Ferrer IR; Wagener ME; Song M; Kirk AD; Larsen CP; Ford ML -
LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function.
Blood Volume: 118 Page(s): 5851 - 5861
11/24/2011 Authors: Reisman NM; Floyd TL; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Transplantation tolerance: memories that haunt us.
Sci Transl Med Volume: 3 Page(s): 86ps22
06/08/2011 Authors: Ford ML; Larsen CP -
Paradoxical aspects of rapamycin immunobiology in transplantation.
Am J Transplant Volume: 11 Page(s): 654 - 659
04/01/2011 Authors: Ferrer IR; Araki K; Ford ML -
Defining Populations of Pathogen-Elicited Donor-Specific Memory T Cells with Different Susceptibility to Costimulatory Blockade.
Volume: 11 Page(s): 153 - 153
04/01/2011 Authors: Kitchens WH; Kirk AD; Larsen CP; Ford ML -
LFA-1 Blockade Induces Effector and Regulatory T Cell Enrichment in Lymph Nodes and Increases Effector T Cell Death.
Volume: 11 Page(s): 153 - 153
04/01/2011 Authors: Ford ML; Reisman NM; Floyd TL; Wagener ME; Kirk AD; Larsen CP -
CD40/CD154 Pathway Blockade Mediates Conversion of Antigen-Specific CDC+ T Cells into FoxP3(+) Cells and Inhibits CD8(+) T Cell Effector Function.
Volume: 11 Page(s): 342 - 342
04/01/2011 Authors: Ferrer IR; Wagener ME; Song M; Kirk AD; Ford ML; Larsen CP -
Targeting the "Therapeutic Window" in Transplantation Via Differential Expression of LFA-1 on Pathogen vs. Allograft-Specific CD8(+) T Cells.
Volume: 11 Page(s): 474 - 474
04/01/2011 Authors: Haridas D; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Rapamycin Augments CD8(+) T Cell Responses to Latent and Chronic Viral Infections but Not Heterologous Immune Graft-Reactive Responses.
Volume: 11 Page(s): 153 - 153
04/01/2011 Authors: Ferrer IR; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Limiting the Amount and Duration of Antigen Exposure during Priming Increases Memory T Cell Requirement for Costimulation during Recall.
Volume: 11 Page(s): 219 - 219
04/01/2011 Authors: Ford ML; Floyd TL; Koehn BH; Kitchens WH; Robertson JM; Cheeseman JA; Stempora LL; Larsen CP -
Integrin Antagonists Prevent Costimulatory Blockade-Resistant Transplant Rejection by CD8(+) Memory T Cells
Volume: 11 Page(s): 477 - 477
04/01/2011 Authors: Kitchens WH; Haridas D; Kirk AD; Larsen CP; Ford ML -
Sirolimus enhances the magnitude and quality of viral-specific CD8+ T-cell responses to vaccinia virus vaccination in rhesus macaques.
Am J Transplant Volume: 11 Page(s): 613 - 618
03/01/2011 Authors: Turner AP; Shaffer VO; Araki K; Martens C; Turner PL; Gangappa S; Ford ML; Ahmed R; Kirk AD; Larsen CP -
Integrin antagonists for transplant immunosuppression: panacea or peril?
Immunotherapy Volume: 3 Page(s): 305 - 307
03/01/2011 Authors: Kitchens WH; Larsen CP; Ford ML -
Limiting the amount and duration of antigen exposure during priming increases memory T cell requirement for costimulation during recall.
J Immunol Volume: 186 Page(s): 2033 - 2041
02/15/2011 Authors: Floyd TL; Koehn BH; Kitchens WH; Robertson JM; Cheeseman JA; Stempora L; Larsen CP; Ford ML -
CD28 blockade induces division-dependent downregulation of interleukin-2 receptor alpha.
Transpl Immunol Volume: 24 Page(s): 94 - 99
01/15/2011 Authors: Ford ML; Stempora LL; Larsen CP -
Selective targeting of human alloresponsive CD8+ effector memory T cells based on CD2 expression.
Am J Transplant Volume: 11 Page(s): 22 - 33
01/01/2011 Authors: Lo DJ; Weaver TA; Stempora L; Mehta AK; Ford ML; Larsen CP; Kirk AD -
LFA-1-specific therapy prolongs allograft survival in rhesus macaques.
J Clin Invest Volume: 120 Page(s): 4520 - 4531
12/01/2010 Authors: Badell IR; Russell MC; Thompson PW; Turner AP; Weaver TA; Robertson JM; Avila JG; Cano JA; Johnson BE; Song M -
Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses.
J Immunol Volume: 185 Page(s): 2004 - 2008
08/15/2010 Authors: Ferrer IR; Wagener ME; Robertson JM; Turner AP; Araki K; Ahmed R; Kirk AD; Larsen CP; Ford ML -
Overcoming the memory barrier in tolerance induction: molecular mimicry and functional heterogeneity among pathogen-specific T-cell populations.
Curr Opin Organ Transplant Volume: 15 Page(s): 405 - 410
08/01/2010 Authors: Ford ML; Larsen CP -
High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade.
Transplantation Volume: 89 Page(s): 1208 - 1217
05/27/2010 Authors: Floyd TL; Orr SB; Coley SM; Hanna SS; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Donor-Reactive CD8+T Cells Induce Sustained DC Activation and Enhance Graft-Specific Th1 Polarization.
Volume: 10 Page(s): 202 - 203
04/01/2010 Authors: Ford ML; Liu D; Stempora L; Larsen CP -
Beyond Trafficking: Blockade of LFA-1/ICAM Critically Impacts CD8+T Cell Acquisition of Donor-Specific Cytokine Production and Cytolytic Activity
Volume: 10 Page(s): 463 - 463
04/01/2010 Authors: Reisman NM; Wagener M; Ferrer IR; Kirk AD; Larsen CP; Ford ML -
Rapamycin Augments Pathogen-Specific but Not Donor-Reactive CD8(+) T Cell Responses
Volume: 10 Page(s): 159 - 159
04/01/2010 Authors: Ferrer IR; Wagener ME; Robertson JM; Turner AP; Kirk AD; Larsen CP; Ford ML -
'Lymphoid Urban Planning': Effects of Blockade of the LFA:ICAM Interaction in Lymphocyte Trafficking
Volume: 10 Page(s): 365 - 365
04/01/2010 Authors: Reisman NM; Wagener M; Kirk AD; Larsen CP; Ford ML -
Anti-LFA-1 Synergizes with CD28/CD154 Blockade To Inhibit Anti-Donor Cytotoxicity and Promote Graft Survival in Recipients Possessing Donor-Reactive Memory T Cells
Volume: 10 Page(s): 41 - 41
04/01/2010 Authors: Ford ML; Kitchens WH; Robertson JM; Kirk AD; Larsen CP -
Surmounting the Memory Barrier: Anti-VLA-4 Improves Transplant Survival with Costimulatory Blockade in a Murine Model of Donor-Specific Memory Response
Volume: 10 Page(s): 557 - 557
04/01/2010 Authors: Kitchens WH; Wagener ME; Larsen CP; Ford ML -
Defining Populations of Donor-Specific Memory T Cells with Different Susceptibility to Costimulatory Blockade
Volume: 10 Page(s): 557 - 557
04/01/2010 Authors: Kitchens WH; Wagener M; Larsen CP; Ford ML -
CD40/CD154 Pathway Blockade Critically Alters Dendritic Cell Phenotype and Function To Impair Graft Rejection
Volume: 10 Page(s): 361 - 361
04/01/2010 Authors: Ford ML; Liu D; Stempora L; Hanna SS; Larsen CP -
CD40/CD154 Pathway Blockade Prolongs Graft Survival While Inhibiting CD8(+) T Cell Activation and Differentiation
Volume: 10 Page(s): 361 - 361
04/01/2010 Authors: Ferrer IR; Wagener ME; Kirk AD; Ford ML; Larsen CP -
Selective Targeting of Human Alloresponsive CD8(+) Effector Memory T Cells Based on CD2 Expression.
Volume: 10 Page(s): 558 - 558
04/01/2010 Authors: Lo DJ; Weaver TA; Stempora L; Mehta AK; Ford ML; Larsen CP; Kirk AD -
Research Priorities for Assessing Health Effects from the Gulf of Mexico Oil Spill: A Letter Report
Page(s): 1 - 16
01/01/2010 Authors: Goldman L; Cohen DE; Dominici F; Goldstein B; Kass N; Le M-N; Mattox GA; McCauley LA; Ness RB; Palinkas LA -
Anti-LFA-1 Synergizes with CD28/CD154 Blockade To Inhibit Anti-Donor Cytotoxicity and Promote Graft Survival in Recipients Possessing Donor-Reactive Memory T Cells
Volume: 10 Page(s): 9 - 9
01/01/2010 Authors: Ford ML; Steeds CM; Wagener ME; Robertson JM; Hanna SS; Kirk AD; Larsen CP -
Memory T-cell-specific therapeutics in organ transplantation.
Curr Opin Organ Transplant Volume: 14 Page(s): 643 - 649
12/01/2009 Authors: Page AJ; Ford ML; Kirk AD -
Anti-CD40 monoclonal antibody synergizes with CTLA4-Ig in promoting long-term graft survival in murine models of transplantation.
J Immunol Volume: 183 Page(s): 1625 - 1635
08/01/2009 Authors: Gilson CR; Milas Z; Gangappa S; Hollenbaugh D; Pearson TC; Ford ML; Larsen CP -
Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction.
Transplantation Volume: 87 Page(s): S69 - S74
05/15/2009 Authors: Ford ML; Kirk AD; Larsen CP -
Translating costimulation blockade to the clinic: lessons learned from three pathways.
Immunol Rev Volume: 229 Page(s): 294 - 306
05/01/2009 Authors: Ford ML; Larsen CP -
IFN-gamma dictates allograft fate via opposing effects on the graft and on recipient CD8 T cell responses.
J Immunol Volume: 182 Page(s): 225 - 233
01/01/2009 Authors: Coley SM; Ford ML; Hanna SC; Wagener ME; Kirk AD; Larsen CP -
Anti-LFA-1 and CTLA-4 Ig Synergize in Attenuating Donor-Reactive CD4+and CD8+T Cell Responses and in Prolonging Graft Survival.
Volume: 9 Page(s): 539 - 539
01/01/2009 Authors: Reisman NM; Wagener ME; Kirk AD; Larsen CP; Ford ML -
Overcoming the Memory Barrier: Role of Anti-LFA-1 in Promoting Long-Term Graft Survival in Recipients Possessing Donor-Reactive Memory T Cells.
Volume: 9 Page(s): 536 - 536
01/01/2009 Authors: Ford ML; Wagener ME; Cooper SS; Kirk AD; Larsen CP -
Impact of Naive Donor-Reactive Precursor Frequency on the Differentiation of Costimulation-Independent CD8+Memory T Cells.
Volume: 9 Page(s): 333 - 333
01/01/2009 Authors: Ford ML; Floyd TL; Wagener ME; Hanna SS; Stempora L; Hendrix R; Kirk AD; Larsen CP -
Distribution of Alloreactivity within CD8(+) T Cell Subsets in the Rhesus Macaque.
Volume: 9 Page(s): 473 - 473
01/01/2009 Authors: Turner A; Weaver T; Stempora L; Iwakoshi N; Ford M; Kirk A; Larsen C -
Impact of CD40/CD154 Pathway Blockade on Donor-Reactive T Cell Expansion and Differentiation.
Volume: 9 Page(s): 631 - 631
01/01/2009 Authors: Ferrer IR; Hanna SS; Kirk AD; Ford ML; Larsen CP -
Alemtuzumab-Mediated Depletion in CD52 Transgenic (Tg) Mice: A Model of Memory-Dominant, Lymphopenic Allograft Rejection.
Volume: 9 Page(s): 541 - 542
01/01/2009 Authors: Ahmed Z; Charafeddine A; Hanna S; Weaver TA; Iwakoshi NN; Kean LS; Ford ML; Larsen CP; Kirk AD -
PD-1-dependent mechanisms maintain peripheral tolerance of donor-reactive CD8+ T cells to transplanted tissue.
J Immunol Volume: 181 Page(s): 5313 - 5322
10/15/2008 Authors: Koehn BH; Ford ML; Ferrer IR; Borom K; Gangappa S; Kirk AD; Larsen CP -
TCR antagonism by peptide requires high TCR expression.
J Immunol Volume: 181 Page(s): 1760 - 1766
08/01/2008 Authors: Jones DS; Reichardt P; Ford ML; Edwards LJ; Evavold BD -
A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection.
J Immunol Volume: 180 Page(s): 7203 - 7211
06/01/2008 Authors: Ford ML; Wagener ME; Hanna SS; Pearson TC; Kirk AD; Larsen CP -
Linked antigen-specific high frequency T cells augment effector activity but not accumulation of low frequency CD8+ donor-reactive T cell responses following CD28/CD154 blockade.
Volume: 8 Page(s): 418 - 418
05/01/2008 Authors: Ford ML; Wagener ME; Kirk AD; Larsen CP -
CD8+ memory T cells specific for a single surrogate minor antigen are sufficient to inhibit transplant tolerance induced by CTLA-4 ig and anti-CD154
Volume: 8 Page(s): 293 - 293
05/01/2008 Authors: Ford ML; Steeds CM; Wagener ME; Kirk AD; Larsen CP -
A critical precursor frequency of donor-reactive CD4+T cell help is required for CD8+T cell-mediated costimulation blockade-resistant rejection
Volume: 8 Page(s): 618 - 618
05/01/2008 Authors: Ford ML; Wagener MS; Hanna SS; Pearson TC; Larsen CP -
Loss of IFN-gamma enables the expansion of autoreactive CD4+ T cells to induce experimental autoimmune encephalomyelitis by a nonencephalitogenic myelin variant antigen.
J Immunol Volume: 180 Page(s): 4451 - 4457
04/01/2008 Authors: Sabatino JJ; Shires J; Altman JD; Ford ML; Evavold BD -
Antigenic disparity impacts outcome of agonism but not blockade of costimulatory pathways in experimental transplant models.
Am J Transplant Volume: 7 Page(s): 1471 - 1481
06/01/2007 Authors: Ford ML; Wagener ME; Gangappa S; Pearson TC; Larsen CP -
Antigenic disparity impacts efficacy of agonism but not blockade of costimulatory pathways in experimental transplant models.
Volume: 7 Page(s): 202 - 202
05/01/2007 Authors: Ford ML; Wagener ME; Gangappa S; Pearson TC; Larsen CP -
Antigen-specific precursor frequency critically impacts CD8+T cell proliferation. differentiation, and requirement for costimulation.
Volume: 7 Page(s): 223 - 223
05/01/2007 Authors: Ford ML; Koehn BH; Wagener ME; Jiang W; Ganappa S; Pearson TC; Larsen CP -
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation.
J Exp Med Volume: 204 Page(s): 299 - 309
02/19/2007 Authors: Ford ML; Koehn BH; Wagener ME; Jiang W; Gangappa S; Pearson TC; Larsen CP -
Modulation of MOG 37-50-specific CD8+ T cell activation and expansion by CD43.
Cell Immunol Volume: 240 Page(s): 53 - 61
03/01/2006 Authors: Ford ML; Evavold BD -
Inhibition of T-cell activation by CD28 and CD40L blockade is influenced by T-cell precursor frequency.
Volume: 119 Page(s): S100 - S101
01/01/2006 Authors: Ford M; Koehn B; Waener M; Borom K; Gangappa S; Pearson T; Larsen C -
CD4+T cell susceptibility to costimulation blockade-mediated tolerance is dependent on tcr affinity for peptide : MHC.
Volume: 5 Page(s): 366 - 366
05/01/2005 Authors: Ford ML; Koehn B; Borom K; Gangappa S; Pearson TC; Larsen CP -
Amelioration of established experimental autoimmune encephalomyelitis by an MHC anchor-substituted variant of proteolipid protein 139-151.
J Immunol Volume: 174 Page(s): 3352 - 3358
03/15/2005 Authors: Margot CD; Ford ML; Evavold BD -
Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis.
Eur J Immunol Volume: 35 Page(s): 76 - 85
01/01/2005 Authors: Ford ML; Evavold BD -
Degenerate recognition of T cell epitopes: impact of T cell receptor reserve and stability of peptide:MHC complexes.
Mol Immunol Volume: 40 Page(s): 1019 - 1025
02/01/2004 Authors: Ford ML; Evavold BD -
An MHC anchor-substituted analog of myelin oligodendrocyte glycoprotein 35-55 induces IFN-gamma and autoantibodies in the absence of experimental autoimmune encephalomyelitis and optic neuritis.
Eur J Immunol Volume: 34 Page(s): 388 - 397
02/01/2004 Authors: Ford ML; Evavold BD -
Defining the parameters necessary for T-cell recognition of ligands that vary in potency.
Immunol Res Volume: 29 Page(s): 29 - 40
01/01/2004 Authors: Kilgore NE; Ford ML; Margot CD; Jones DS; Reichardt P; Evavold BD -
CD43 modulates severity and onset of experimental autoimmune encephalomyelitis.
J Immunol Volume: 171 Page(s): 6527 - 6533
12/15/2003 Authors: Ford ML; Onami TM; Sperling AI; Ahmed R; Evavold BD -
Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of myelin oligodendrocyte glycoprotein 35-55.
J Immunol Volume: 171 Page(s): 1247 - 1254
08/01/2003 Authors: Ford ML; Evavold BD -
Induction of polyomavirus-specific CD8(+) T lymphocytes by distinct dendritic cell subpopulations.
J Virol Volume: 75 Page(s): 544 - 547
01/01/2001 Authors: Drake DR; Shawver ML; Hadley A; Butz E; Maliszewski C; Lukacher AE