Martin Pinter PhD

Department of Physiology
Professor Emeritus

(404) 727-3472
mpinter@emory.edu

Academic Appointment

Education

Degrees

PhD from Medical College of Wisconsin
BS from Marquette University

Research

Focus

Research interests are in several areas. 1) Motor neuron disease Investigation of an inherited form of motor neuron disease (MND) in dogs represents the central focus of my lab. Most work in MND concerns mechanisms underlying degenerative events while our work indicates that these may occur well after motor unit function is lost.

Publications

Abnormal response of distal Schwann cells to denervation in a mouse model of motor neuron disease.
Exp Neurol Volume: 278 Page(s): 116 - 126
04/01/2016 Authors: Carrasco DI; Bahr BA; Seburn KL; Pinter MJ
Synaptic Deficits at Neuromuscular Junctions in Two Mouse Models of Charcot-Marie-Tooth Type 2d.
J Neurosci Volume: 36 Page(s): 3254 - 3267
03/16/2016 Authors: Spaulding EL; Sleigh JN; Morelli KH; Pinter MJ; Burgess RW; Seburn KL
Reversible Recruitment of a Homeostatic Reserve Pool of Synaptic Vesicles Underlies Rapid Homeostatic Plasticity of Quantal Content.
J Neurosci Volume: 36 Page(s): 828 - 836
01/20/2016 Authors: Wang X; Pinter MJ; Rich MM
Altered terminal Schwann cell morphology precedes denervation in SOD1 mice.
Exp Neurol Volume: 275 Pt 1 Page(s): 172 - 181
01/01/2016 Authors: Carrasco DI; Seburn KL; Pinter MJ
PROGRESSIVE SYNAPTIC DEFICITS REDUCE THE SAFETY FACTOR AT NEUROMUSCULAR JUNCTIONS IN TWO MOUSE MODELS OF CHARCOT-MARIE-TOOTH TYPE 2D
Volume: 20 Page(s): 235 - 236
06/01/2015 Authors: Spaulding EL; Sleigh JN; Pinter MJ; Burgess RW; Sebum KL
Sodium channel slow inactivation as a therapeutic target for myotonia congenita.
Ann Neurol Volume: 77 Page(s): 320 - 332
02/01/2015 Authors: Novak KR; Norman J; Mitchell JR; Pinter MJ; Rich MM
Motor terminal degeneration unaffected by activity changes in SOD1(G93A) mice; a possible role for glycolysis.
Neurobiol Dis Volume: 48 Page(s): 132 - 140
10/01/2012 Authors: Carrasco DI; Bichler EK; Rich MM; Wang X; Seburn KL; Pinter MJ
Permanent central synaptic disconnection of proprioceptors after nerve injury and regeneration. II. Loss of functional connectivity with motoneurons.
J Neurophysiol Volume: 106 Page(s): 2471 - 2485
11/01/2011 Authors: Bullinger KL; Nardelli P; Pinter MJ; Alvarez FJ; Cope TC
Recovery of proprioceptive feedback from nerve crush.
J Physiol Volume: 589 Page(s): 4935 - 4947
10/15/2011 Authors: Prather JF; Nardelli P; Nakanishi ST; Ross KT; Nichols TR; Pinter MJ; Cope TC
Nerve terminal degeneration is independent of muscle fiber genotype in SOD1 mice.
PLoS One Volume: 5 Page(s): e9802
03/22/2010 Authors: Carrasco DI; Bichler EK; Seburn KL; Pinter MJ
Ca2+ dependence of the binomial parameters p and n at the mouse neuromuscular junction.
J Neurophysiol Volume: 103 Page(s): 659 - 666
02/01/2010 Authors: Wang X; Pinter MJ; Rich MM
Role of Ca(2+) in injury-induced changes in sodium current in rat skeletal muscle.
Am J Physiol Cell Physiol Volume: 297 Page(s): C352 - C359
08/01/2009 Authors: Filatov GN; Pinter MJ; Rich MM
Enhanced transmission at a spinal synapse triggered in vivo by an injury signal independent of altered synaptic activity.
J Neurosci Volume: 27 Page(s): 12851 - 12859
11/21/2007 Authors: Bichler EK; Nakanishi ST; Wang Q-B; Pinter MJ; Rich MM; Cope TC
Rat motoneuron properties recover following reinnervation in the absence of muscle activity and evoked acetylcholine release.
J Physiol Volume: 585 Page(s): 47 - 56
11/15/2007 Authors: Bichler EK; Carrasco DI; Rich MM; Cope TC; Pinter MJ
Prolongation of evoked and spontaneous synaptic currents at the neuromuscular junction after activity blockade is caused by the upregulation of fetal acetylcholine receptors.
J Neurosci Volume: 26 Page(s): 8983 - 8987
08/30/2006 Authors: Wang X; Engisch KL; Teichert RW; Olivera BM; Pinter MJ; Rich MM
Resting potential-dependent regulation of the voltage sensitivity of sodium channel gating in rat skeletal muscle in vivo.
J Gen Physiol Volume: 126 Page(s): 161 - 172
08/01/2005 Authors: Filatov GN; Pinter MJ; Rich MM
Decerebrate mammalian preparations: unalleviated or fully alleviated pain? A review and opinion.
Contemp Top Lab Anim Sci Volume: 44 Page(s): 34 - 36
07/01/2005 Authors: Silverman J; Garnett NL; Giszter SF; Heckman CJ; Kulpa-Eddy JA; Lemay MA; Perry CK; Pinter M
Central suppression of regenerated proprioceptive afferents.
J Neurosci Volume: 25 Page(s): 4733 - 4742
05/11/2005 Authors: Haftel VK; Bichler EK; Wang Q-B; Prather JF; Pinter MJ; Cope TC
Regulation of motoneuron excitability via motor endplate acetylcholine receptor activation.
J Neurosci Volume: 25 Page(s): 2226 - 2232
03/02/2005 Authors: Nakanishi ST; Cope TC; Rich MM; Carrasco DI; Pinter MJ
Activity-dependent presynaptic regulation of quantal size at the mammalian neuromuscular junction in vivo.
J Neurosci Volume: 25 Page(s): 343 - 351
01/12/2005 Authors: Wang X; Li Y; Engisch KL; Nakanishi ST; Dodson SE; Miller GW; Cope TC; Pinter MJ; Rich MM
Decreased synaptic activity shifts the calcium dependence of release at the mammalian neuromuscular junction in vivo.
J Neurosci Volume: 24 Page(s): 10687 - 10692
11/24/2004 Authors: Wang X; Engisch KL; Li Y; Pinter MJ; Cope TC; Rich MM
Activity-driven synaptic and axonal degeneration in canine motor neuron disease.
J Neurophysiol Volume: 92 Page(s): 1175 - 1181
08/01/2004 Authors: Carrasco DI; Rich MM; Wang Q; Cope TC; Pinter MJ
Movement reduces the dynamic response of muscle spindle afferents and motoneuron synaptic potentials in rat.
J Neurophysiol Volume: 91 Page(s): 2164 - 2171
05/01/2004 Authors: Haftel VK; Bichler EK; Nichols TR; Pinter MJ; Cope TC
Crucial role of sodium channel fast inactivation in muscle fibre inexcitability in a rat model of critical illness myopathy.
J Physiol Volume: 547 Page(s): 555 - 566
03/01/2003 Authors: Rich MM; Pinter MJ
Reduced neuromuscular quantal content with normal synaptic release time course and depression in canine motor neuron disease.
J Neurophysiol Volume: 88 Page(s): 3305 - 3314
12/01/2002 Authors: Rich MM; Wang X; Cope TC; Pinter MJ
Reduced endplate currents underlie motor unit dysfunction in canine motor neuron disease.
J Neurophysiol Volume: 88 Page(s): 3293 - 3304
12/01/2002 Authors: Rich MM; Waldeck RF; Cork LC; Balice-Gordon RJ; Fyffe REW; Wang X; Cope TC; Pinter MJ
Inactivation of sodium channels causes sodium conductance to decrease below that necessary for action potential initiation in a rat model of acute quadriplegic myopathy
ANNALS OF NEUROLOGY Volume: 52 Page(s): S47 - S47
09/01/2002 Authors: Rich MM; Pinter MJ
Quantal content is reduced at neuromuscular junctions in hereditary canine spinal muscular atrophy
ANNALS OF NEUROLOGY Volume: 52 Page(s): S93 - S93
09/01/2002 Authors: Pinter MJ; Cope TC; Rich MM
Sodium channel inactivation in an animal model of acute quadriplegic myopathy
NEUROMUSCULAR DISORDERS Volume: 11 Page(s): 667 - 667
09/01/2001 Authors: Rich MM; Pinter MJ
Neuromuscular transmission failure in hereditary canine spinal muscular atrophy
NEUROMUSCULAR DISORDERS Volume: 11 Page(s): 646 - 646
09/01/2001 Authors: Rich MM; Cope TC; Pinter MJ
Homologous transplantation of prepubertal testes in the dog.
Transplantation Volume: 72 Page(s): 552 - 553
08/15/2001 Authors: Pullium JK; Lin PH; Pinter MJ
Sodium channel inactivation in an animal model of acute quadriplegic myopathy.
Ann Neurol Volume: 50 Page(s): 26 - 33
07/01/2001 Authors: Rich MM; Pinter MJ
Canine motor neuron disease: clinicopathologic features and selected indicators of oxidative stress.
J Vet Intern Med Volume: 15 Page(s): 112 - 119
01/01/2001 Authors: Green SL; Bouley DM; Pinter MJ; Cork LC; Vatassery GT
Congenital bilateral ureteral stenosis and hydronephrosis in a neonatal puppy.
Contemp Top Lab Anim Sci Volume: 39 Page(s): 34 - 36
09/01/2000 Authors: Pullium JK; Dillehay DL; Webb S; Pinter MJ
Functional motor unit failure precedes neuromuscular degeneration in canine motor neuron disease.
Ann Neurol Volume: 47 Page(s): 596 - 605
05/01/2000 Authors: Balice-Gordon RJ; Smith DB; Goldman J; Cork LC; Shirley A; Cope TC; Pinter MJ
Nerve injury induces gap junctional coupling among axotomized adult motor neurons.
J Neurosci Volume: 20 Page(s): 674 - 684
01/15/2000 Authors: Chang Q; Pereda A; Pinter MJ; Balice-Gordon RJ
Gap junctional coupling and patterns of connexin expression among neonatal rat lumbar spinal motor neurons.
J Neurosci Volume: 19 Page(s): 10813 - 10828
12/15/1999 Authors: Chang Q; Gonzalez M; Pinter MJ; Balice-Gordon RJ
Alterations in cyclin-dependent protein kinase 5 (CDK5) protein levels, activity and immunocytochemistry in canine motor neuron disease.
J Neuropathol Exp Neurol Volume: 57 Page(s): 1070 - 1077
11/01/1998 Authors: Green SL; Vulliet PR; Pinter MJ; Cork LC
Loss of electrical excitability in an animal model of acute quadriplegic myopathy.
Ann Neurol Volume: 43 Page(s): 171 - 179
02/01/1998 Authors: Rich MM; Pinter MJ; Kraner SD; Barchi RL
Gap junctional communication among motor neurons in development and after nerve damage
Page(s): 188 - 192
01/01/1998 Authors: Chang Q; Pereda A; Pinter MJ; Balice-Gordon RJ
Hereditary canine spinal muscular atrophy: genetics, neurophysiology, and pathology.
J Neurol Sci Volume: 152 Suppl 1 Page(s): S74
10/01/1997 Authors: Cork LC; Green SL; Pinter MJ
Effects of 4-aminopyridine on muscle and motor unit force in canine motor neuron disease.
J Neurosci Volume: 17 Page(s): 4500 - 4507
06/01/1997 Authors: Pinter MJ; Waldeck RF; Cope TC; Cork LC
Regenerated dorsal root fibers form functional synapses in embryonic spinal cord transplants.
J Neurophysiol Volume: 76 Page(s): 1236 - 1245
08/01/1996 Authors: Itoh Y; Waldeck RF; Tessler A; Pinter MJ
Pathology of end-stage homozygous hereditary canine motor neuron disease
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY Volume: 55 Page(s): 222 - 222
05/01/1996 Authors: Cork LC; Green S; Pinter MJ
Motoneuronal projection pattern of single C3-C4 propriospinal neurones.
Can J Physiol Pharmacol Volume: 74 Page(s): 518 - 530
04/01/1996 Authors: Tantisira B; Alstermark B; Isa T; Kmmel H; Pinter M
Properties of motor units after self-reinnervation of the cat superior oblique muscle.
J Neurophysiol Volume: 74 Page(s): 2309 - 2318
12/01/1995 Authors: Waldeck RF; Murphy EH; Pinter MJ
Motor unit behavior in canine motor neuron disease.
J Neurosci Volume: 15 Page(s): 3447 - 3457
05/01/1995 Authors: Pinter MJ; Waldeck RF; Wallace N; Cork LC
Adult spinal motoneurons remain viable despite prolonged absence of functional synaptic contact with muscle.
Exp Neurol Volume: 123 Page(s): 147 - 156
09/01/1993 Authors: Vanden Noven S; Wallace N; Muccio D; Turtz A; Pinter MJ
Time courses of calcium and calcium-bound buffers following calcium influx in a model cell.
Biophys J Volume: 64 Page(s): 77 - 91
01/01/1993 Authors: Nowycky MC; Pinter MJ
Transplant mediated mechanisms of locomotor recovery.
Restor Neurol Neurosci Volume: 5 Page(s): 64 - 65
01/01/1993 Authors: Tessler A; Goldberger ME; Himes BT; Howland DR; Itoh Y; Pinter MJ
Descending pathways mediating disynaptic excitation of dorsal neck motoneurones in the cat: facilitatory interactions.
Neurosci Res Volume: 15 Page(s): 32 - 41
10/01/1992 Authors: Alstermark B; Pinter MJ; Sasaki S
Descending pathways mediating disynaptic excitation of dorsal neck motoneurones in the cat: brain stem relay.
Neurosci Res Volume: 15 Page(s): 42 - 57
10/01/1992 Authors: Alstermark B; Pinter MJ; Sasaki S
Tectal and tegmental excitation in dorsal neck motoneurones of the cat.
J Physiol Volume: 454 Page(s): 517 - 532
08/01/1992 Authors: Alstermark B; Pinter MJ; Sasaki S
Trigeminal excitation of dorsal neck motoneurones in the cat.
Exp Brain Res Volume: 92 Page(s): 183 - 193
01/01/1992 Authors: Alstermark B; Pinter MJ; Sasaki S; Tantisira B
Axotomy-like changes in cat motoneuron electrical properties elicited by botulinum toxin depend on the complete elimination of neuromuscular transmission.
J Neurosci Volume: 11 Page(s): 657 - 666
03/01/1991 Authors: Pinter MJ; Vanden Noven S; Muccio D; Wallace N
Integration in descending motor pathways controlling the forelimb in the cat. 17. Axonal projection and termination of C3-C4 propriospinal neurones in the C6-Th1 segments.
Exp Brain Res Volume: 81 Page(s): 447 - 461
01/01/1990 Authors: Alstermark B; Kmmel H; Pinter MJ; Tantisira B
Effects of preventing reinnervation on axotomized spinal motoneurons in the cat. II. Changes in group Ia synaptic function.
J Neurophysiol Volume: 62 Page(s): 325 - 333
08/01/1989 Authors: Vanden Noven S; Pinter MJ
Effects of preventing reinnervation on axotomized spinal motoneurons in the cat. I. Motoneuron electrical properties.
J Neurophysiol Volume: 62 Page(s): 311 - 324
08/01/1989 Authors: Pinter MJ; Vanden Noven S
Branching and termination of C3-C4 propriospinal neurones in the cervical spinal cord of the cat.
Neurosci Lett Volume: 74 Page(s): 291 - 296
03/09/1987 Authors: Alstermark B; Kmmel H; Pinter MJ; Tantisira B
Vestibular effects in long C3-C5 propriospinal neurones.
Brain Res Volume: 404 Page(s): 389 - 394
02/24/1987 Authors: Alstermark B; Lundberg A; Pinter M; Sasaki S
Long C3-C5 propriospinal neurones in the cat.
Brain Res Volume: 404 Page(s): 382 - 388
02/24/1987 Authors: Alstermark B; Lundberg A; Pinter M; Sasaki S
Subpopulations and functions of long C3-C5 propriospinal neurones.
Brain Res Volume: 404 Page(s): 395 - 400
02/24/1987 Authors: Alstermark B; Lundberg A; Pinter M; Sasaki S
The effect of axotomy on posttetanic potentiation of group Ia synapses in the cat.
J Neurophysiol Volume: 56 Page(s): 1174 - 1184
10/01/1986 Authors: Gustafsson B; Pinter MJ; Wigstrm H
Cross-reinnervated motor units in cat muscle. II. Soleus muscle reinnervated by flexor digitorum longus motoneurons.
J Neurophysiol Volume: 54 Page(s): 837 - 851
10/01/1985 Authors: Dum RP; O'Donovan MJ; Toop J; Tsairis P; Pinter MJ; Burke RE
Kinesiological studies of self- and cross-reinnervated FDL and soleus muscles in freely moving cats.
J Neurophysiol Volume: 54 Page(s): 852 - 866
10/01/1985 Authors: O'Donovan MJ; Pinter MJ; Dum RP; Burke RE
Pyramidal effects in dorsal neck motoneurones of the cat.
J Physiol Volume: 363 Page(s): 287 - 302
06/01/1985 Authors: Alstermark B; Pinter MJ; Sasaki S
Factors determining the variation of the afterhyperpolarization duration in cat lumbar alpha-motoneurones.
Brain Res Volume: 326 Page(s): 392 - 395
02/11/1985 Authors: Gustafsson B; Pinter MJ
An investigation of threshold properties among cat spinal alpha-motoneurones.
J Physiol Volume: 357 Page(s): 453 - 483
12/01/1984 Authors: Gustafsson B; Pinter MJ
Relations among passive electrical properties of lumbar alpha-motoneurones of the cat.
J Physiol Volume: 356 Page(s): 401 - 431
11/01/1984 Authors: Gustafsson B; Pinter MJ
Effects of axotomy on the distribution of passive electrical properties of cat motoneurones.
J Physiol Volume: 356 Page(s): 433 - 442
11/01/1984 Authors: Gustafsson B; Pinter MJ
Influence of post-synaptic properties on the time course of synaptic potentials in different types of cat lumbar alpha-motoneurons.
Neurosci Lett Volume: 51 Page(s): 67 - 72
09/28/1984 Authors: Gustafsson B; Pinter MJ
Voltage threshold and excitability among variously sized cat hindlimb motoneurons.
J Neurophysiol Volume: 50 Page(s): 644 - 657
09/01/1983 Authors: Pinter MJ; Curtis RL; Hosko MJ
Posttetanic potentiation of group Ia EPSPs: possible mechanisms for differential distribution among medial gastrocnemius motoneurons.
J Neurophysiol Volume: 50 Page(s): 379 - 398
08/01/1983 Authors: Lev-Tov A; Pinter MJ; Burke RE
Brainstem relay of disynaptic pyramidal EPSPs to neck motoneurons in the cat.
Brain Res Volume: 259 Page(s): 147 - 150
01/17/1983 Authors: Alstermark B; Pinter M; Sasaki S
Convergence on reticulospinal neurons mediating contralateral pyramidal disynaptic EPSPs to neck motoneurons.
Brain Res Volume: 259 Page(s): 151 - 154
01/17/1983 Authors: Alstermark B; Pinter M; Sasaki S
EVIDENCE FOR SYSTEMATIC VARIATION OF MEMBRANE TIME CONSTANT AMONG CAT MOTONEURONES
JOURNAL OF PHYSIOLOGY-LONDON Volume: 345 Page(s): P59 - P59
01/01/1983 Authors: GUSTAFSSON B; PINTER MJ
A HRP study of the relation between cell size and motor unit type in cat ankle extensor motoneurons.
J Comp Neurol Volume: 209 Page(s): 17 - 28
07/20/1982 Authors: Burke RE; Dum RP; Fleshman JW; Glenn LL; Lev-Tov A; O'Donovan MJ; Pinter MJ
Actions of FDL and FHL muscles in intact cats: functional dissociation between anatomical synergists.
J Neurophysiol Volume: 47 Page(s): 1126 - 1143
06/01/1982 Authors: O'Donovan MJ; Pinter MJ; Dum RP; Burke RE
Supraspinal facilitation of cutaneous polysynaptic EPSPs in cat medical gastrocnemius motoneurons.
Exp Brain Res Volume: 45 Page(s): 133 - 143
01/01/1982 Authors: Pinter MJ; Burke RE; O'Donovan MJ; Dum RP
Response of the quiescent heart tube to mechanical stretch in the intact chick embryo.
Dev Biol Volume: 61 Page(s): 330 - 337
12/01/1977 Authors: Rajala GM; Pinter MJ; Kaplan S

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Martin Pinter PhD

Academic Appointment

Education

Degrees

Research

Focus

Publications