Michael Owens PhD

Department of Psychiatry and Behavioral Sciences
Professor

Academic Appointment

Professor (tenure), Psychiatry and Behavioral Sciences, Emory University, Atlanta
Faculty, Graduate School of Arts and Sciences, Department of Molecular & Systems Pharmacology, Emory University, Atlanta
Faculty, Graduate School of Arts and Sciences, Department of Neuroscience, Emory University, Atlanta

Education

Degrees

PhD Pharmacology & Toxicology from Duke University, Durham
BS Pharmacy from Duquesne University, Pittsburgh

Research

Focus

My research focuses on the pharmacology of antidepressant, anxiolytic, and antipsychotic drugs with particular emphasis on neuropeptide transmitters as targets for novel pharmacotherapeutics. Research also focuses on biological markers in the diagnosis and treatment of psychiatric disease, laboratory tests to optimize current psychotropic drug therapy, and the pharmacokinetics of drugs in laboratory animals.

Publications

Amygdala connectivity is associated with withdrawn/depressed behavior in a large sample of children from the Adolescent Brain Cognitive Development (ABCD) Study.
Psychiatry Res Neuroimaging Volume: 344 Page(s): 111877
10/01/2024 Authors: Thomas E; Juliano A; Owens M; Cupertino RB; Mackey S; Hermosillo R; Miranda-Dominguez O; Conan G; Ahmed M; Fair DA
Locus Coeruleus Noradrenergic Modulation of Diurnal Corticosterone, Stress Reactivity, and Cardiovascular Homeostasis in Male Rats.
Neuroendocrinology Volume: 112 Page(s): 763 - 776
01/01/2022 Authors: Thrivikraman KV; Kinkead B; Owens MJ; Rapaport MH; Plotsky PM
Erratum to "Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor" [Bioorg. Med. Chem. 23 (2015) 4286-4302].
Bioorg Med Chem Volume: 28 Page(s): 115660
10/01/2020 Authors: Stehouwer JS; Birnbaum MS; Voll RJ; Owens MJ; Plott SJ; Bourke CH; Wassef MA; Kilts CD; Goodman MM
Fetal Antidepressant Exposure and Outcomes
Volume: 85 Page(s): S319 - S319
05/15/2019 Authors: Kalin M; Cochran A; Newport DJ; Knight B; Morris N; Ritchie J; Owens M; Stowe Z
Test-Retest Reliability of the SERT Imaging Agent 11C-HOMADAM in Healthy Humans.
J Nucl Med Volume: 59 Page(s): 315 - 319
02/01/2018 Authors: Adhikarla V; Dunlop BW; Jarkas N; Goodman MM; Mayberg H; Owens MJ; Nye JA
Early Life Stress Associated With Increased Striatal N-Acetyl-Aspartate: Cerebrospinal Fluid Corticotropin-Releasing Factor Concentrations, Hippocampal Volume, Body Mass and Behavioral Correlates.
Chronic Stress (Thousand Oaks) Volume: 2
01/01/2018 Authors: Coplan JD; Lu D; El Sehamy AM; Tang C; Jackowski AP; Abdallah CG; Nemeroff CB; Owens MJ; Mathew SJ; Gorman JM
Adult glucocorticoid receptor mRNA expression volatility in response to an acute stressor and juvenile CSF corticotropin-releasing factor: A pilot neurodevelopmental study.
Neurosci Lett Volume: 647 Page(s): 20 - 25
04/24/2017 Authors: Syed SA; Smith ELP; Batuman O; Rosenblum LA; Owens MJ; Nemeroff CB; Coplan JD
Prenatal stress-induced increases in hippocampal von Willebrand factor expression are prevented by concurrent prenatal escitalopram.
Physiol Behav Volume: 172 Page(s): 24 - 30
04/01/2017 Authors: Neigh GN; Nemeth CL; Kelly SD; Hardy EE; Bourke C; Stowe ZN; Owens MJ
Exposure to Paliperidone in Utero and via Breast Milk: Drug Clearance and Implications for an Animal Model of Human Exposure
Volume: 41 Page(s): S172 - S172
12/01/2016 Authors: Owens M; Zejnelovic F; Ritchie J; Zhang F; Jin P; Plott S
In vivo investigation of escitalopram's allosteric site on the serotonin transporter.
Pharmacol Biochem Behav Volume: 141 Page(s): 50 - 57
02/01/2016 Authors: Murray KE; Ressler KJ; Owens MJ
In Utero Exposure to Clinically Relevant Concentrations of Paliperidone Does Not Affect Several Measures of Development or Early Measures of Cognition in Rats
Volume: 40 Page(s): S127 - S127
12/01/2015 Authors: Owens M; Plott S; Zejnelovik F; Stowe Z; Kinkead B
Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors.
Bioorg Med Chem Lett Volume: 25 Page(s): 5111 - 5114
11/15/2015 Authors: Stehouwer JS; Bourke CH; Owens MJ; Voll RJ; Kilts CD; Goodman MM
Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent femalerats.
Neuropharmacology Volume: 97 Page(s): 251 - 258
10/01/2015 Authors: Ehrlich DE; Neigh GN; Bourke CH; Nemeth CL; Hazra R; Ryan SJ; Rowson S; Jairam N; Sholar CA; Rainnie DG
Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.
Bioorg Med Chem Volume: 23 Page(s): 4286 - 4302
08/01/2015 Authors: Stehouwer JS; Birnbaum MS; Voll RJ; Owens MJ; Plott SJ; Bourke CH; Wassef MA; Kilts CD; Goodman MM
Erratum to: Prenatal exposure to escitalopram and/or stress in rats : A prenatal stress model of maternal depression and its treatment.
Psychopharmacology (Berl) Volume: 231 Page(s): 4583
12/01/2014 Authors: Bourke CH; Capello CF; Rogers SM; Yu ML; Boss-Williams KA; Weiss JM; Stowe ZN; Owens MJ
Estimates of Serotonin or Norepinephrine Transporter Occupancy Do Not Predict Antidepressant Response in a 12 Week Trial
Volume: 39 Page(s): S460 - S461
12/01/2014 Authors: Owens M; Dunlop B; Plott S; Zejnelovic F; Craighead WE; Mayberg H; Nemeroff C
CSF Oxytocin (OT) in Maternal Stress: Influence on HPA Axis
Volume: 75 Page(s): 313S - 313S
05/01/2014 Authors: Karim AA; Chandra P; St Germain G; Perera TD; Owens MJ; Nemeroff CB; Coplan JD
Synthesis, radiosynthesis, and rat microPET evaluation of an F-18 CRF-1 receptor PET tracer
Volume: 55
05/01/2014 Authors: Stehouwer J; Birnbaum M; Voll R; Owens M; Kilts C; Goodman M
Effects of duloxetine on norepinephrine and serotonin transporter activity in healthy subjects.
J Clin Psychopharmacol Volume: 34 Page(s): 9 - 16
02/01/2014 Authors: Chappell JC; Eisenhofer G; Owens MJ; Haber H; Lachno DR; Dean RA; Knadler MP; Nemeroff CB; Mitchell MI; Detke MJ
Early life stress and macaque amygdala hypertrophy: preliminary evidence for a role for the serotonin transporter gene.
Front Behav Neurosci Volume: 8 Page(s): 342
01/01/2014 Authors: Coplan JD; Fathy HM; Jackowski AP; Tang CY; Perera TD; Mathew SJ; Martinez J; Abdallah CG; Dwork AJ; Pantol G
Prenatal antidepressant exposure: clinical and preclinical findings.
Pharmacol Rev Volume: 66 Page(s): 435 - 465
01/01/2014 Authors: Bourke CH; Stowe ZN; Owens MJ
Escitalopram alters gene expression and HPA axis reactivity in rats following chronic overexpression of corticotropin-releasing factor from the central amygdala.
Psychoneuroendocrinology Volume: 38 Page(s): 1349 - 1361
08/01/2013 Authors: Flandreau EI; Bourke CH; Ressler KJ; Vale WW; Nemeroff CB; Owens MJ
Neuroendocrine homeostasis after vagus nerve stimulation in rats.
Psychoneuroendocrinology Volume: 38 Page(s): 1067 - 1077
07/01/2013 Authors: Thrivikraman KV; Zejnelovic F; Bonsall RW; Owens MJ
Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.
Psychopharmacology (Berl) Volume: 228 Page(s): 231 - 241
07/01/2013 Authors: Bourke CH; Capello CF; Rogers SM; Yu ML; Boss-Williams KA; Weiss JM; Stowe ZN; Owens MJ
In vivo dialysis setup with a loop injection valve facilitates retrodialysis studies.
J Pharmacol Toxicol Methods Volume: 68 Page(s): 217 - 224
01/01/2013 Authors: Thrivikraman KV; Kinkead B; Murray KE; Owens MJ
Prenatal exposure to escitalopram and/or stress in rats produces limited effects on endocrine, behavioral, or gene expression measures in adult male rats.
Neurotoxicol Teratol Volume: 39 Page(s): 100 - 109
01/01/2013 Authors: Bourke CH; Stowe ZN; Neigh GN; Olson DE; Owens MJ
Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors.
Sci Transl Med Volume: 4 Page(s): 161ra151
11/21/2012 Authors: Rye DB; Bliwise DL; Parker K; Trotti LM; Saini P; Fairley J; Freeman A; Garcia PS; Owens MJ; Ritchie JC
Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects.
Biol Psychiatry Volume: 72 Page(s): 238 - 243
08/01/2012 Authors: Coccaro EF; Lee R; Owens MJ; Kinkead B; Nemeroff CB
Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial.
Trials Volume: 13 Page(s): 106
07/09/2012 Authors: Dunlop BW; Binder EB; Cubells JF; Goodman MM; Kelley ME; Kinkead B; Kutner M; Nemeroff CB; Newport DJ; Owens MJ
Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus.
Psychoneuroendocrinology Volume: 37 Page(s): 27 - 38
01/01/2012 Authors: Flandreau EI; Ressler KJ; Owens MJ; Nemeroff CB
Depression, antidepressants, and neurogenesis: a critical reappraisal.
Neuropsychopharmacology Volume: 36 Page(s): 2589 - 2602
12/01/2011 Authors: Hanson ND; Owens MJ; Nemeroff CB
Several stressors fail to reduce adult hippocampal neurogenesis.
Psychoneuroendocrinology Volume: 36 Page(s): 1520 - 1529
11/01/2011 Authors: Hanson ND; Owens MJ; Boss-Williams KA; Weiss JM; Nemeroff CB
Endogenous GABA(A) Receptor Enhancement Modulates Vigilance in the Primary Hypersomnias
Volume: 70 Page(s): S23 - S23
10/01/2011 Authors: Rye DB; Parker K; Trotti LM; Garcia PS; Ritchie JC; Owens MJ; Morrow L; Bliwise DL; Jenkins A
Serotonin transporter occupancy in rats exposed to serotonin reuptake inhibitors in utero or via breast milk.
J Pharmacol Exp Ther Volume: 339 Page(s): 275 - 285
10/01/2011 Authors: Capello CF; Bourke CH; Ritchie JC; Stowe ZN; Newport DJ; Nemeroff A; Owens MJ
Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine.
J Clin Psychiatry Volume: 72 Page(s): 1124 - 1128
08/01/2011 Authors: Bonne O; Gill JM; Luckenbaugh DA; Collins C; Owens MJ; Alesci S; Neumeister A; Yuan P; Kinkead B; Manji HK
Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult bonnet monkeys.
Physiol Behav Volume: 103 Page(s): 535 - 539
07/06/2011 Authors: Coplan JD; Abdallah CG; Mathew SJ; Shungu DC; Mao X; Smith ELP; Kaufman D; Gorman JM; Owens MJ; Nemeroff CB
Persistent anxiolytic affects after chronic administration of the CRF receptor antagonist R121919 in rats.
Neuropharmacology Volume: 60 Page(s): 1135 - 1141
06/01/2011 Authors: Gutman DA; Owens MJ; Thrivikraman KV; Nemeroff CB
Gene expression analysis in a rat model of maternal depression and in utero SSRI exposure
Volume: 25
04/01/2011 Authors: Bourke CH; Capello CF; Owens MJ
Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus.
J Pharmacol Exp Ther Volume: 337 Page(s): 180 - 186
04/01/2011 Authors: Hanson ND; Nemeroff CB; Owens MJ
Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study.
Psychoneuroendocrinology Volume: 36 Page(s): 289 - 293
02/01/2011 Authors: Coplan JD; Abdallah CG; Kaufman J; Gelernter J; Smith ELP; Perera TD; Dwork AJ; Kaffman A; Gorman JM; Rosenblum LA
THE LONG-TERM GENE EXPRESSION EFFECTS OF PRENATAL SSRI EXPOSURE AND/OR PRENATAL STRESS.
Volume: 50 Page(s): 1065 - 1065
09/01/2010 Authors: Bourke CH; Capello CF; Olson DE; Owens MJ
Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.
J Med Chem Volume: 53 Page(s): 5549 - 5557
08/12/2010 Authors: Stehouwer JS; Daniel LM; Chen P; Voll RJ; Williams L; Plott SJ; Votaw JR; Owens MJ; Howell L; Goodman MM
Test-retest reliability of the SERT imaging agent [11C]HOMADAM in healthy humans
Volume: 52 Page(s): S110 - S110
08/01/2010 Authors: Nye JA; Owens MJ; Dunlop B; Jarkas N; Mayberg H; Goodman MM
A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor.
Biol Psychiatry Volume: 67 Page(s): 1212 - 1216
06/15/2010 Authors: Martin EI; Ressler KJ; Jasnow AM; Dabrowska J; Hazra R; Rainnie DG; Nemeroff CB; Owens MJ
Changes in the vascular area fraction of the hippocampus and amygdala are induced by prenatal dexamethasone and/or adult stress.
J Cereb Blood Flow Metab Volume: 30 Page(s): 1100 - 1104
06/01/2010 Authors: Neigh GN; Owens MJ; Taylor WR; Nemeroff CB
Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.
Arch Gen Psychiatry Volume: 67 Page(s): 369 - 379
04/01/2010 Authors: Binder EB; Owens MJ; Liu W; Deveau TC; Rush AJ; Trivedi MH; Fava M; Bradley B; Ressler KJ; Nemeroff CB
Cardiac arrest and cardiopulmonary resuscitation dysregulates the hypothalamic-pituitary-adrenal axis.
J Cereb Blood Flow Metab Volume: 29 Page(s): 1673 - 1682
10/01/2009 Authors: Neigh GN; Karelina K; Zhang N; Glasper ER; Owens MJ; Plotsky PM; Nemeroff CB; Devries AC
Abstract PI-57: Pharmacokinetic/Pharmacodynamic Modeling of Inhibition of Serotonin and Norepinephrine Uptake by Duloxetine and Escitalopram in Healthy Subjects (vol 85, pg S26, 2009)
CLINICAL PHARMACOLOGY & THERAPEUTICS Volume: 86 Page(s): 221 - 221
08/01/2009 Authors: Lobo E; Ernest CS; Detke M; Pangallo B; Knadler MP; Chappell J; Plott S; Owens MJ
The role of serotonin in the pathophysiology of depression: as important as ever.
Clin Chem Volume: 55 Page(s): 1578 - 1579
08/01/2009 Authors: Nemeroff CB; Owens MJ
Security of Attachment as a Function of Maternal Social Rank; Hypothalamo-Pituitary-Adrenal Axis Correlates
Volume: 65 Page(s): 45S - 45S
04/15/2009 Authors: Chandra P; Smith EL; Owens MJ; Nemeroff CB; Rosenblum LA; Coplan JD
PHARMACOKINETIC/PHARMACODYNAMIC MODELING OF INHIBITION OF SEROTONIN AND NOREPINEPHRINE UPTAKE BY DULOXETINE AND ESCITALOPRAM IN HEALTHY SUBJECTS
Volume: 85 Page(s): S26 - S26
01/01/2009 Authors: Lobo E; Ernest CS; Detke M; Pangallo B; Knadler MP; Chappell J; Plott S; Owens MJ
Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes.
Mol Psychiatry Volume: 14 Page(s): 37 - 50
01/01/2009 Authors: Keen-Rhinehart E; Michopoulos V; Toufexis DJ; Martin EI; Nair H; Ressler KJ; Davis M; Owens MJ; Nemeroff CB; Wilson ME
Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.
J Med Chem Volume: 51 Page(s): 7788 - 7799
12/25/2008 Authors: Stehouwer JS; Jarkas N; Zeng F; Voll RJ; Williams L; Camp VM; Malveaux EJ; Votaw JR; Howell L; Owens MJ
Estimates of serotonin and norepinephrine transporter inhibition in depressed patients treated with paroxetine or venlafaxine.
Neuropsychopharmacology Volume: 33 Page(s): 3201 - 3212
12/01/2008 Authors: Owens MJ; Krulewicz S; Simon JS; Sheehan DV; Thase ME; Carpenter DJ; Plott SJ; Nemeroff CB
Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test.
Psychoneuroendocrinology Volume: 33 Page(s): 1093 - 1101
09/01/2008 Authors: Gutman DA; Coyer MJ; Boss-Williams KA; Owens MJ; Nemeroff CB; Weiss JM
The antidepressant sertraline downregulates Akt and has activity against melanoma cells.
Pigment Cell Melanoma Res Volume: 21 Page(s): 451 - 456
08/01/2008 Authors: Reddy KK; Lefkove B; Chen LB; Govindarajan B; Carracedo A; Velasco G; Carrillo CO; Bhandarkar SS; Owens MJ; Mechta-Grigoriou F
Endogenous neurotensin is involved in estrous cycle related alterations in prepulse inhibition of the acoustic startle reflex in female rats.
Psychoneuroendocrinology Volume: 33 Page(s): 178 - 187
02/01/2008 Authors: Kinkead B; Yan F; Owens MJ; Nemeroff CB
Synthesis and in vivo evaluation of halogenated N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine derivatives as PET serotonin transporter ligands.
J Med Chem Volume: 51 Page(s): 271 - 281
01/24/2008 Authors: Jarkas N; Voll RJ; Williams L; Votaw JR; Owens M; Goodman MM
Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter.
Bioorg Med Chem Volume: 16 Page(s): 783 - 793
01/15/2008 Authors: Zeng F; Jarkas N; Stehouwer JS; Voll RJ; Owens MJ; Kilts CD; Nemeroff CB; Goodman MM
Decreased cerebrospinal fluid concentrations of substance P in treatment-resistant depression and lack of alteration after acute adjunct vagus nerve stimulation therapy.
Psychiatry Res Volume: 157 Page(s): 123 - 129
01/15/2008 Authors: Carpenter LL; Bayat L; Moreno F; Kling MA; Price LH; Tyrka AR; Kinkead B; Owens MJ; Nemeroff CB
Preparation of antidepressants for use in preclinical research.
Int J Neuropsychopharmacol Volume: 10 Page(s): 759 - 763
12/01/2007 Authors: McConathy J; Capello C; Jarkas N; Stowe ZN; Owens MJ
New pharmacological tools in evaluation of antidepressant molecules
Volume: 17 Page(s): S610 - S610
10/01/2007 Authors: Owens MJ
The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal.
Eur J Pharmacol Volume: 571 Page(s): 17 - 24
09/24/2007 Authors: Skelton KH; Oren D; Gutman DA; Easterling K; Holtzman SG; Nemeroff CB; Owens MJ
Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent.
J Med Chem Volume: 50 Page(s): 4553 - 4560
09/20/2007 Authors: Plisson C; Stehouwer JS; Voll RJ; Howell L; Votaw JR; Owens MJ; Goodman MM
Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes.
Am J Psychiatry Volume: 164 Page(s): 1214 - 1220
08/01/2007 Authors: Newport DJ; Calamaras MR; DeVane CL; Donovan J; Beach AJ; Winn S; Knight BT; Gibson BB; Viguera AC; Owens MJ
Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents.
Bioorg Med Chem Lett Volume: 17 Page(s): 3044 - 3047
06/01/2007 Authors: Zeng F; Stehouwer JS; Jarkas N; Voll RJ; Williams L; Camp VM; Votaw JR; Owens MJ; Kilts CD; Nemeroff CB
The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal.
Psychopharmacology (Berl) Volume: 192 Page(s): 385 - 396
06/01/2007 Authors: Skelton KH; Gutman DA; Thrivikraman KV; Nemeroff CB; Owens MJ
Genetic variants in genes regulating the corticotropin releasing hormone (CRH) system and response to citalopram in the STAR*D sample
Volume: 61 Page(s): 172S - 172S
04/15/2007 Authors: Binder EB; Owens MJ; Liu W; Fava M; Rush AJ; Trivedi MH; Cubells JF; Nemeroff CB
Could neurotensin receptor antagonists also be antipsychotics?
Volume: 31 Page(s): S244 - S244
12/01/2006 Authors: Caceda R; Kinkead B; Owens MJ; Nemeroff CB
Lack of physiological regulation of the expression of co-chaperones of the glucocorticoid receptor in periparturn depression
Volume: 31 Page(s): S135 - S135
12/01/2006 Authors: Katz ER; Deveau TC; Capello CF; Owens MJ; Newport DJ; Stowe ZN; Cubells JF; Binder EB
Stress results in region specific decreases in expression of angiogenic factors in the brain
Volume: 31 Page(s): S161 - S161
12/01/2006 Authors: Neigh GN; Binder EB; Plotsky PM; Owens MJ; Taylor WR; Nemeroff CB
Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.
J Med Chem Volume: 49 Page(s): 6760 - 6767
11/16/2006 Authors: Stehouwer JS; Jarkas N; Zeng F; Voll RJ; Williams L; Owens MJ; Votaw JR; Goodman MM
Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position.
Bioorg Med Chem Lett Volume: 16 Page(s): 4661 - 4663
09/01/2006 Authors: Zeng F; Jarkas N; Owens MJ; Kilts CD; Nemeroff CB; Goodman MM
Medications in pregnancy: Defining exposure
JOURNAL OF WOMENS HEALTH Volume: 15 Page(s): 686 - 686
07/01/2006 Authors: Owens MJ; Stowe ZN
Therapeutic drug monitoring of psychoactive drugs during pregnancy in the genomic era: challenges and opportunities.
J Psychopharmacol Volume: 20 Page(s): 54 - 59
07/01/2006 Authors: DeVane CL; Stowe ZN; Donovan JL; Newport DJ; Pennell PB; Ritchie JC; Owens MJ; Wang J-S
Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations.
Ann N Y Acad Sci Volume: 1071 Page(s): 525 - 533
07/01/2006 Authors: Coplan JD; Smith ELP; Altemus M; Mathew SJ; Perera T; Kral JG; Gorman JM; Owens MJ; Nemeroff CB; Rosenblum LA
Cardiac arrest and cardiopulmonary resuscitation increases CRF R1 receptor binding
Volume: 27 Page(s): 12 - 13
05/01/2006 Authors: Neigh GN; Glasper ER; Nemeroff CB; Owens MW; Plotsky PM; DeVries AC
Elevated cerebrospinal fluid substance p concentrations in posttraumatic stress disorder and major depression.
Am J Psychiatry Volume: 163 Page(s): 637 - 643
04/01/2006 Authors: Geracioti TD; Carpenter LL; Owens MJ; Baker DG; Ekhator NN; Horn PS; Strawn JR; Sanacora G; Kinkead B; Price LH
Algorithmically designed peptides ameliorate behavioral defects in animal model of ADHD by an allosteric mechanism.
J Neurosci Methods Volume: 151 Page(s): 68 - 81
02/15/2006 Authors: Kinkead B; Selz KA; Owens MJ; Mandell AJ
Placental passage of tricyclic antidepressants.
Biol Psychiatry Volume: 59 Page(s): 287 - 290
02/01/2006 Authors: Loughhead AM; Stowe ZN; Newport DJ; Ritchie JC; DeVane CL; Owens MJ
Serotonin and norepinephrine transporter binding profile of SSRIs.
Essent Psychopharmacol Volume: 7 Page(s): 35 - 41
01/01/2006 Authors: Gutman DA; Owens MJ
Antidepressants in amniotic fluid: another route of fetal exposure.
Am J Psychiatry Volume: 163 Page(s): 145 - 147
01/01/2006 Authors: Loughhead AM; Fisher AD; Newport DJ; Ritchie JC; Owens MJ; DeVane CL; Stowe ZN
Virally mediated increased neurotensin 1 receptor in the nucleus accumbens decreases behavioral effects of mesolimbic system activation.
J Neurosci Volume: 25 Page(s): 11748 - 11756
12/14/2005 Authors: Cceda R; Kinkead B; Owens MJ; Nemeroff CB
Variable foraging demand (VFD) exposure of primate maternal-infant dyads and impaired insulin action in juvenile offspring
Volume: 30 Page(s): S154 - S154
12/01/2005 Authors: Coplan JD; Kaufman D; Shorman I; Smith EL; Owens MJ; Nemeroff CB; Rosenblum LA; Kral JG; Banerji M
The electrophysiological effects of neurotensin on spontaneously active neurons in the nucleus accumbens: an in vivo study.
Synapse Volume: 58 Page(s): 165 - 172
12/01/2005 Authors: Stowe ZN; Landry JC; Tang Z; Owens MJ; Kinkead B; Nemeroff CB
Viral vector-induced overexpression of the NT, receptor in the nucleus accumbens: Further evidence for antipsychotic effects of increased NTergic neurotransmission
Volume: 30 Page(s): S48 - S49
12/01/2005 Authors: Nemeroff CB; Caceda R; Owens MJ; Kinkead B
The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density.
BMC Genet Volume: 6 Page(s): 55
11/27/2005 Authors: VanNess SH; Owens MJ; Kilts CD
Effects of paroxetine and venlafaxine XR on heart rate variability in depression.
J Clin Psychopharmacol Volume: 25 Page(s): 480 - 484
10/01/2005 Authors: Davidson J; Watkins L; Owens M; Krulewicz S; Connor K; Carpenter D; Krishnan R; Nemeroff C
Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agents.
Nucl Med Biol Volume: 32 Page(s): 593 - 605
08/01/2005 Authors: McConathy J; Owens MJ; Kilts CD; Malveaux EJ; Votaw JR; Nemeroff CB; Goodman MM
Synchronized maternal-infant elevations of primate CSF CRF concentrations in response to variable foraging demand.
CNS Spectr Volume: 10 Page(s): 530 - 536
07/01/2005 Authors: Coplan JD; Altemus M; Mathew SJ; Smith EL; Sharf B; Coplan PM; Kral JG; Gorman JM; Owens MJ; Nemeroff CB
Genetic analysis of the hypothalamic corticotropin-releasing factor system.
Endocrinology Volume: 146 Page(s): 2362 - 2368
05/01/2005 Authors: Garlow SJ; Boone E; Li W; Owens MJ; Nemeroff CB
The VNTR element in dat1 regulates in vitro DAT density and ligand dissociation constant: Evidence implicating N-linked glycosylation in modulating genotype-dependent effects
Volume: 57 Page(s): 63S - 63S
04/15/2005 Authors: VanNess SH; Owens MJ; Kilts CD
Short-term corticosterone administration does not change erythropoietin receptor expression in the rat hippocampus
Volume: 57 Page(s): 120S - 121S
04/15/2005 Authors: Hanson ND; Jutras M; Plotsky PM; Nemeroff CB; Owens MJ
Serotonin transporter occupancy in rats exposed to SSRIs in utero or via breast milk
Volume: 57 Page(s): 85S - 85S
04/15/2005 Authors: Owens MJ
Antipsychotic drug-like effects of virally mediated overexpression of the neurotensin 1 receptor in the rat nucleus accumbens
Volume: 57 Page(s): 42S - 43S
04/15/2005 Authors: Caceda R; Kinkead B; Owens MJ; Nemeroff CB
The effect of corticosterone on diurnal differences in rat dorsal raphe gene expression
Volume: 57 Page(s): 27S - 27S
04/15/2005 Authors: Thrivikraman KV; Kinkead B; Gernert KM; Nemeroff CB; Plotsky PM; Owens MJ
Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters.
Nucl Med Biol Volume: 32 Page(s): 211 - 224
04/01/2005 Authors: Jarkas N; Votaw JR; Voll RJ; Williams L; Camp VM; Owens MJ; Purselle DC; Bremner JD; Kilts CD; Nemeroff CB
Synchronized maternal-infant elevations of primate CSFCRF in response to variable foraging demand
Volume: 29 Page(s): S96 - S97
12/01/2004 Authors: Coplan JD; Altemus M; Mathew SJ; Smith EL; Scharf B; Coplan PM; Kral JS; Perera T; Dwork A; Gorman JM
The expanding potential clinical utility of CRF, receptor antagonists: From mood and anxiety disorders to drug withdrawal
Volume: 29 Page(s): S44 - S44
12/01/2004 Authors: Nemeroff CB; Owens MJ; Heim C; Newport DJ
Serotonin transporter occupancy in rats exposed to SSRIs in utero or via breast milk
Volume: 29 Page(s): S160 - S161
12/01/2004 Authors: Owens MJ; Capello C; Goren D; Stowe ZN
Genetic analysis of hypothalamic corticotropin releasing factor (CRF) system
Volume: 29 Page(s): S140 - S141
12/01/2004 Authors: Boone E; Li W; Owens MJ; Nemeroff CB; Garlow SJ
Algorithmically designed allosteric peptides ameliorate behavioral defects in animal model of ADHD
Volume: 29 Page(s): S124 - S124
12/01/2004 Authors: Kinkead B; Selz KA; Owens MJ; Mandell AJ
Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugs.
Neuropsychopharmacology Volume: 29 Page(s): 2200 - 2207
12/01/2004 Authors: Binder EB; Kinkead B; Owens MJ; Nemeroff CB
Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation.
Psychopharmacology (Berl) Volume: 176 Page(s): 248 - 255
11/01/2004 Authors: Arborelius L; Hawks BW; Owens MJ; Plotsky PM; Nemeroff CB
Spontaneous withdrawal from the triazolobenzodiazepine alprazolam increases cortical corticotropin-releasing factor mRNA expression.
J Neurosci Volume: 24 Page(s): 9303 - 9312
10/20/2004 Authors: Skelton KH; Nemeroff CB; Owens MJ
Development of molecular targets for understanding and treating stress-related disorders
Volume: 14 Page(s): S148 - S149
10/01/2004 Authors: Owens MJ; Hanson N; Gutman DA
Increased cerebrospinal fluid corticotropin-releasing factor concentrations during tryptophan depletion in healthy adults.
Biol Psychiatry Volume: 56 Page(s): 531 - 534
10/01/2004 Authors: Tyrka AR; Carpenter LL; McDougle CJ; Kirwin PD; Owens MJ; Nemeroff CB; Strong DR; Price LH
Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter.
Nucl Med Biol Volume: 31 Page(s): 705 - 718
08/01/2004 Authors: McConathy J; Owens MJ; Kilts CD; Malveaux EJ; Camp VM; Votaw JR; Nemeroff CB; Goodman MM
Pharmacologic differences among the SSRIs: focus on monoamine transporters and the HPA axis.
CNS Spectr Volume: 9 Page(s): 23 - 31
06/01/2004 Authors: Nemeroff CB; Owens MJ
The 3 ' VNTR element in dat1 regulates in vitro DAT binding site density
Volume: 55 Page(s): 10S - 10S
04/15/2004 Authors: VanNess SH; Owens MJ; Kilts CD
Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects.
Neuropsychopharmacology Volume: 29 Page(s): 777 - 784
04/01/2004 Authors: Carpenter LL; Tyrka AR; McDougle CJ; Malison RT; Owens MJ; Nemeroff CB; Price LH
Designing human m1 muscarinic receptor-targeted hydrophobic eigenmode matched peptides as functional modulators.
Biophys J Volume: 86 Page(s): 1308 - 1331
03/01/2004 Authors: Selz KA; Mandell AJ; Shlesinger MF; Arcuragi V; Owens MJ
Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity.
Biol Psychiatry Volume: 55 Page(s): 320 - 322
02/01/2004 Authors: Vaishnavi SN; Nemeroff CB; Plott SJ; Rao SG; Kranzler J; Owens MJ
Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond.
J Clin Psychiatry Volume: 65 Suppl 4 Page(s): 5 - 10
01/01/2004 Authors: Owens MJ
Alterations in platelet serotonin transporter binding in women with postpartum onset major depression.
J Psychiatr Res Volume: 38 Page(s): 467 - 473
01/01/2004 Authors: Newport DJ; Owens MJ; Knight DL; Ragan K; Morgan N; Nemeroff CB; Stowe ZN
Effects of paroxetine and venlafaxine-XR on heart rate variability in depression
Volume: 13 Page(s): S274 - S274
09/01/2003 Authors: Watkins L; Davidson JRT; Connor KM; Beebe KL; Krulewicz S; Abraham K; Zhang W; Owens M; Nemeroff CB
Cellular and behavioral effects of D2 dopamine receptor hydrophobic eigenmode-targeted peptide ligands.
Neuropsychopharmacology Volume: 28 Suppl 1 Page(s): S98 - 107
07/01/2003 Authors: Mandell AJ; Selz KA; Owens MJ; Kinkead B; Shlesinger MF; Gutman DA; Arguragi V
The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems.
J Pharmacol Exp Ther Volume: 305 Page(s): 434 - 439
05/01/2003 Authors: Gilmor ML; Skelton KH; Nemeroff CB; Owens MJ
Elevated levels of central stress mediators in irritable bowel syndrome
Volume: 124 Page(s): A252 - A252
04/01/2003 Authors: Fitzgerald LZ; Chang L; Lee CK; Owens MJ; Mayer M; Naliboff BD; Nemeroff CB; Mayer EA
Stereochemistry in Drug Action.
Prim Care Companion J Clin Psychiatry Volume: 5 Page(s): 70 - 73
04/01/2003 Authors: McConathy J; Owens MJ
Cerebrospinal fluid corticotropin-releasing factor (CRF) and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis.
Neuropsychopharmacology Volume: 28 Page(s): 569 - 576
03/01/2003 Authors: Newport DJ; Heim C; Owens MJ; Ritchie JC; Ramsey CH; Bonsall R; Miller AH; Nemeroff CB
The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress.
J Pharmacol Exp Ther Volume: 304 Page(s): 874 - 880
02/01/2003 Authors: Gutman DA; Owens MJ; Skelton KH; Thrivikraman KV; Nemeroff CB
The pharmacokinetics of sertraline excretion into human breast milk: determinants of infant serum concentrations.
J Clin Psychiatry Volume: 64 Page(s): 73 - 80
01/01/2003 Authors: Stowe ZN; Hostetter AL; Owens MJ; Ritchie JC; Sternberg K; Cohen LS; Nemeroff CB
Pharmacology of valproate.
Psychopharmacol Bull Volume: 37 Suppl 2 Page(s): 17 - 24
01/01/2003 Authors: Owens MJ; Nemeroff CB
Neuropharmacology of paroxetine.
Psychopharmacol Bull Volume: 37 Suppl 1 Page(s): 8 - 18
01/01/2003 Authors: Nemeroff CB; Owens MJ
Treatment of mood disorders.
Nat Neurosci Volume: 5 Suppl Page(s): 1068 - 1070
11/01/2002 Authors: Nemeroff CB; Owens MJ
Inhibition of norepinephrine uptake in patients with major depression treated with paroxetine.
Am J Psychiatry Volume: 159 Page(s): 1702 - 1710
10/01/2002 Authors: Gilmor ML; Owens MJ; Nemeroff CB
Cerebrospinal fluid concentrations of biogenic amines and corticotropin-releasing factor in adolescent non-human primates as a function of the timing of adverse early rearing.
Stress Volume: 5 Page(s): 185 - 193
09/01/2002 Authors: Mathew SJ; Coplan JD; Smith ELP; Scharf BA; Owens MJ; Nemeroff CB; Mann JJ; Gorman JM; Rosenblum LA
Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques.
Psychoneuroendocrinology Volume: 27 Page(s): 651 - 660
08/01/2002 Authors: Rosenblum LA; Smith ELP; Altemus M; Scharf BA; Owens MJ; Nemeroff CB; Gorman JM; Coplan JD
Relationship between CSF corticotropin releasing factor and perceived early life stress in depressed patients and healthy controls
BIOLOGICAL PSYCHIATRY Volume: 51 Page(s): 136S - 137S
04/15/2002 Authors: Carpenter LL; Pelton GH; Malison RT; Owens MJ; Nemeroff CB; Price LH
Escitalopram: a second-generation SSRI.
CNS Spectr Volume: 7 Page(s): 34 - 39
04/01/2002 Authors: Owens MJ; Rosenbaum JF
Stress invalidates reported effects of sodium valproate on brain CRF systems - Response
NEUROPSYCHOPHARMACOLOGY Volume: 26 Page(s): 413 - 414
03/01/2002 Authors: Stout SC; Owens MJ; Nemeroff CB
Regulation of corticotropin-releasing factor neuronal systems and hypothalamic-pituitary-adrenal axis activity by stress and chronic antidepressant treatment.
J Pharmacol Exp Ther Volume: 300 Page(s): 1085 - 1092
03/01/2002 Authors: Stout SC; Owens MJ; Nemeroff CB
The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs.
Biol Psychiatry Volume: 50 Page(s): 856 - 872
12/01/2001 Authors: Binder EB; Kinkead B; Owens MJ; Nemeroff CB
Neurotensin and dopamine interactions.
Pharmacol Rev Volume: 53 Page(s): 453 - 486
12/01/2001 Authors: Binder EB; Kinkead B; Owens MJ; Nemeroff CB
Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine.
Biol Psychiatry Volume: 50 Page(s): 345 - 350
09/01/2001 Authors: Owens MJ; Knight DL; Nemeroff CB
Paroxetine for the prevention of depression induced by interferon alfa.
N Engl J Med Volume: 345 Page(s): 375 - 376
08/02/2001 Authors: Kraus MR; Schfer A; Scheurlen M
An old transmitter in a new millennium.
CNS Spectr Volume: 6 Page(s): 655
08/01/2001 Authors: Owens MJ; Nemeroff CB
Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates.
Biol Psychiatry Volume: 50 Page(s): 200 - 204
08/01/2001 Authors: Coplan JD; Smith EL; Altemus M; Scharf BA; Owens MJ; Nemeroff CB; Gorman JM; Rosenblum LA
Effects of sodium valproate on corticotropin-releasing factor systems in rat brain.
Neuropsychopharmacology Volume: 24 Page(s): 624 - 631
06/01/2001 Authors: Stout SC; Owens MJ; Lindsey KP; Knight DL; Nemeroff CB
Synthesis and characterization of fluorinated and iodinated pyrrolopyrimidines as PET/SPECT ligands for the CRF1 receptor.
Nucl Med Biol Volume: 28 Page(s): 187 - 195
02/01/2001 Authors: Martarello L; Kilts CD; Ely T; Owens MJ; Nemeroff CB; Camp M; Goodman MM
Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating.
J Neurosci Volume: 21 Page(s): 601 - 608
01/15/2001 Authors: Binder EB; Kinkead B; Owens MJ; Kilts CD; Nemeroff CB
The effects of glutamate receptor agonists on neurotensin release using in vivo microdialysis.
Eur J Pharmacol Volume: 411 Page(s): 129 - 134
01/05/2001 Authors: Radke JM; Owens MJ; Nemeroff CB
Increased responsiveness to citalopram on 5-HT cell firing in adult rats previously subjected to maternal deprivation
NORDIC JOURNAL OF PSYCHIATRY Volume: 55 Page(s): 88 - 88
01/01/2001 Authors: Arborelius L; Hawks BW; Plotsky PM; Nemefoff CB; Owens MJ
Neurokinin(1) receptor antagonists as potential antidepressants.
Annu Rev Pharmacol Toxicol Volume: 41 Page(s): 877 - 906
01/01/2001 Authors: Stout SC; Owens MJ; Nemeroff CB
Are CRF receptor antagonists potential antidepressants?
Hum Psychopharmacol Volume: 16 Page(s): 81 - 87
01/01/2001 Authors: O'Brien D; Skelton KH; Owens MJ; Nemeroff CB
Contribution of modern neuroscience to developing new treatments for psychiatric disorders
Page(s): 61 - 81
01/01/2001 Authors: Nemeroff CB; Owens MJ
Paroxetine in breast milk - Dr. Stowe and colleagues reply
AMERICAN JOURNAL OF PSYCHIATRY Volume: 158 Page(s): 144 - 145
01/01/2001 Authors: Stowe ZN; Cohen LS; Ritchie JC; Owens MJ; Nemeroff CB
The effects of acute antipsychotic drug administration on the neurotensin system of the developing rat brain.
Brain Res Dev Brain Res Volume: 124 Page(s): 1 - 10
11/30/2000 Authors: Kinkead B; Owens MJ; Nemeroff CB
Cerebrospinal fluid corticotropin-releasing hormone in healthy humans: effects of yohimbine and naloxone.
J Clin Endocrinol Metab Volume: 85 Page(s): 4138 - 4145
11/01/2000 Authors: Vythilingam M; Anderson GM; Owens MJ; Halaszynski TM; Bremner JD; Carpenter LL; Heninger GR; Nemeroff CB; Charney DS
Paroxetine binding to the rat norepinephrine transporter in vivo.
Biol Psychiatry Volume: 48 Page(s): 954 - 956
11/01/2000 Authors: Rubin RT
Paroxetine binding to the rat norepinephrine transporter in vivo - Reply
BIOLOGICAL PSYCHIATRY Volume: 48 Page(s): 954 - 956
11/01/2000 Authors: Owens MJ; Nemeroff CB; Knight DL
Sex- and estrous cycle-related differences in the effects of acute antipsychotic drug administration on neurotensin-containing neurons in the rat brain.
J Pharmacol Exp Ther Volume: 295 Page(s): 205 - 211
10/01/2000 Authors: Kinkead B; Lorch SM; Owens MJ; Nemeroff CB
Effects of acute and subchronic administration of typical and atypical antipsychotic drugs on the neurotensin system of the rat brain.
J Pharmacol Exp Ther Volume: 295 Page(s): 67 - 73
10/01/2000 Authors: Kinkead B; Shahid S; Owens MJ; Nemeroff CB
The neurobiology of urocortin.
Regul Pept Volume: 93 Page(s): 85 - 92
09/25/2000 Authors: Skelton KH; Owens MJ; Nemeroff CB
Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations.
Psychiatry Res Volume: 95 Page(s): 93 - 102
08/21/2000 Authors: Coplan JD; Smith EL; Trost RC; Scharf BA; Altemus M; Bjornson L; Owens MJ; Gorman JM; Nemeroff CB; Rosenblum LA
Chronic administration of the selective corticotropin-releasing factor 1 receptor antagonist CP-154,526: behavioral, endocrine and neurochemical effects in the rat.
J Pharmacol Exp Ther Volume: 294 Page(s): 588 - 597
08/01/2000 Authors: Arborelius L; Skelton KH; Thrivikraman KV; Plotsky PM; Schulz DW; Owens MJ
Increased corticotropin-releasing factor concentrations in the bed nucleus of the stria terminalis of anhedonic rats.
Eur J Pharmacol Volume: 401 Page(s): 39 - 46
07/28/2000 Authors: Stout SC; Mortas P; Owens MJ; Nemeroff CB; Moreau J
A comparison of plasma alprazolam concentrations following different routes of chronic administration in the Sprague-Dawley rat: implications for psychotropic drug research.
Psychopharmacology (Berl) Volume: 151 Page(s): 72 - 76
07/01/2000 Authors: Skelton KH; Nemeroff CB; Owens MJ
Paroxetine binding to the rat norepinephrine transporter in vivo.
Biol Psychiatry Volume: 47 Page(s): 842 - 845
05/01/2000 Authors: Owens MJ; Knight DL; Nemeroff CB
CRF1 receptor antagonists as novel putative antidepressants and anxiolytics
BIOLOGICAL PSYCHIATRY Volume: 47 Page(s): 64S - 64S
04/15/2000 Authors: Nemeroff CB; Owens MJ; Skelton K; Guttman D; Winslow JT; Plotsky PM
Platelet activation in treatment responders vs. nonresponders in patients with major depression
BIOLOGICAL PSYCHIATRY Volume: 47 Page(s): 77S - +
04/15/2000 Authors: Mussleman DL; Marzec UM; Owens MJ; Reemsnyder AJ; Goodkin RS; Hanson SR; Nemeroff CB
Synthesis, biodistribution, and primate imaging of fluorine-18 labeled 2beta-carbo-1'-fluoro-2-propoxy-3beta-(4-chlorophenyl)tr opanes. Ligands for the imaging of dopamine transporters by positron emission tomography.
J Med Chem Volume: 43 Page(s): 639 - 648
02/24/2000 Authors: Xing D; Chen P; Keil R; Kilts CD; Shi B; Camp VM; Malveaux G; Ely T; Owens MJ; Votaw J
Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems.
J Neurosci Volume: 20 Page(s): 1240 - 1248
02/01/2000 Authors: Skelton KH; Nemeroff CB; Knight DL; Owens MJ
Paroxetine in human breast milk and nursing infants.
Am J Psychiatry Volume: 157 Page(s): 185 - 189
02/01/2000 Authors: Stowe ZN; Cohen LS; Hostetter A; Ritchie JC; Owens MJ; Nemeroff CB
Norepinephrine: Neurotransmitter for the millennium
Volume: 61 Page(s): 3 - 4
01/01/2000 Authors: Nemeroff CB
18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters.
Nucl Med Biol Volume: 27 Page(s): 1 - 12
01/01/2000 Authors: Goodman MM; Kilts CD; Keil R; Shi B; Martarello L; Xing D; Votaw J; Ely TD; Lambert P; Owens MJ
Corticotropin-releasing factor antagonists in affective disorders.
Expert Opin Investig Drugs Volume: 8 Page(s): 1849 - 1858
11/01/1999 Authors: Owens MJ; Nemeroff CB
The role of corticotropin-releasing factor in depression and anxiety disorders.
J Endocrinol Volume: 160 Page(s): 1 - 12
01/01/1999 Authors: Arborelius L; Owens MJ; Plotsky PM; Nemeroff CB
Neurontensin studies in alcohol naive, preferring and non-preferring rats.
Neuroscience Volume: 93 Page(s): 227 - 236
01/01/1999 Authors: Ehlers CL; Somes C; Li TK; Lumeng L; Kinkead B; Owens MJ; Nemeroff CB
Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography.
Biol Psychiatry Volume: 44 Page(s): 1090 - 1098
12/01/1998 Authors: Malison RT; Price LH; Berman R; van Dyck CH; Pelton GH; Carpenter L; Sanacora G; Owens MJ; Nemeroff CB; Rajeevan N
Use of psychotropic medications during lactation - Drs. Stowe and Owens reply
AMERICAN JOURNAL OF PSYCHIATRY Volume: 155 Page(s): 1643 - 1644
11/01/1998 Authors: Stowe ZN; Owens MJ
Atypical antipsychotic drugs selectively increase neurotensin efflux in dopamine terminal regions.
Proc Natl Acad Sci U S A Volume: 95 Page(s): 11462 - 11464
09/15/1998 Authors: Radke JM; Owens MJ; Ritchie JC; Nemeroff CB
Mode matches in hydrophobic free energy eigenfunctions predict peptide-protein interactions.
Biopolymers Volume: 46 Page(s): 89 - 101
08/01/1998 Authors: Mandell AJ; Owens MJ; Selz KA; Morgan WN; Shlesinger MF; Nemeroff CB
Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis.
Psychiatr Clin North Am Volume: 21 Page(s): 293 - 307
06/01/1998 Authors: Plotsky PM; Owens MJ; Nemeroff CB
Reduced midbrain serotonin transporter binding in major depression as measured by [I-123]beta-CIT SPECT.
JOURNAL OF NUCLEAR MEDICINE Volume: 39 Page(s): 40P - 40P
05/01/1998 Authors: Malison RT; Price LH; Berman R; Pelton GH; Carpenter L; Sanacora G; Owens MJ; Nemeroff CB; Rajeevan N; Baldwin RM
Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions.
Arch Gen Psychiatry Volume: 55 Page(s): 473 - 477
05/01/1998 Authors: Coplan JD; Trost RC; Owens MJ; Cooper TB; Gorman JM; Nemeroff CB; Rosenblum LA
The HPA axis and the pathophysiology of depression: The role of early adverse
BIOLOGICAL PSYCHIATRY Volume: 43 Page(s): 79S - 80S
04/15/1998 Authors: Nemeroff CB; Owens MJ; Plotsky PM
Radiolabeled 2 beta-methoxycarbonyl[TC-99m]cyclo-pentadienyltricarbonyl-3 beta-(4-chlorophenyl)tropane (CPTTDAT): Synthesis, characterization and tissue distribution of a radioligand for mapping dopamine transporter sites by SPECT.
Page(s): 103 - 106
01/01/1998 Authors: Xing A; Shi B; Kilts C; Abak T; Camp V; Malveaux E; Ely T; Owens M; Goodman MM
The serotonin transporter and depression.
Depress Anxiety Volume: 8 Suppl 1 Page(s): 5 - 12
01/01/1998 Authors: Owens MJ; Nemeroff CB
Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
J Pharmacol Exp Ther Volume: 283 Page(s): 1305 - 1322
12/01/1997 Authors: Owens MJ; Morgan WN; Plott SJ; Nemeroff CB
Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine.
Mol Pharmacol Volume: 52 Page(s): 571 - 581
10/01/1997 Authors: Pariante CM; Pearce BD; Pisell TL; Owens MJ; Miller AH
Sertraline and desmethylsertraline in human breast milk and nursing infants.
Am J Psychiatry Volume: 154 Page(s): 1255 - 1260
09/01/1997 Authors: Stowe ZN; Owens MJ; Landry JC; Kilts CD; Ely T; Llewellyn A; Nemeroff CB
The role of early adverse life events in the etiology of depression and posttraumatic stress disorder. Focus on corticotropin-releasing factor.
Ann N Y Acad Sci Volume: 821 Page(s): 194 - 207
06/21/1997 Authors: Heim C; Owens MJ; Plotsky PM; Nemeroff CB
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder.
Am J Psychiatry Volume: 154 Page(s): 624 - 629
05/01/1997 Authors: Bremner JD; Licinio J; Darnell A; Krystal JH; Owens MJ; Southwick SM; Nemeroff CB; Charney DS
Corticotropin-releasing factor (CRF), CRF-binding protein (CRF-BP), and CRF/CRF-BP complex in Alzheimer's disease and control postmortem human brain.
J Neurochem Volume: 68 Page(s): 2053 - 2060
05/01/1997 Authors: Behan DP; Khongsaly O; Owens MJ; Chung HD; Nemeroff CB; De Souza EB
Serotonin transporter binding: Pathophysiology and neuropsychopharmacology
BIOLOGICAL PSYCHIATRY Volume: 41 Page(s): 206 - 206
04/01/1997 Authors: Nemeroff CB; Owens MJ
Persistent changes in corticotropin-releasing factor systems due to early life stress: relationship to the pathophysiology of major depression and post-traumatic stress disorder.
Psychopharmacol Bull Volume: 33 Page(s): 185 - 192
01/01/1997 Authors: Heim C; Owens MJ; Plotsky PM; Nemeroff CB
Effects of antidepressants on the cytochrome P450 system.
Am J Psychiatry Volume: 153 Page(s): 1655 - 1657
12/01/1996 Authors: Preskorn SH
Platelet 5-hydroxytryptamine (5-HT) transporter and 5-HT2A receptor binding after chronic hypercorticosteronemia, (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane administration or neurotoxin-induced depletion of central nervous system 5-HT in the rat.
J Pharmacol Exp Ther Volume: 278 Page(s): 1040 - 1049
09/01/1996 Authors: Owens MJ; Ballenger CA; Knight DL; Nemeroff CB
Why are these people making a CRF receptor antagonist?
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY Volume: 212 Page(s): 197 - MEDI
08/25/1996 Authors: Owens MJ
Incentive bias?
J Clin Psychiatry Volume: 57 Page(s): 265 - 267
06/01/1996 Authors: Lane RM
Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation.
Endocrinology Volume: 137 Page(s): 1212 - 1218
04/01/1996 Authors: Ladd CO; Owens MJ; Nemeroff CB
Postmortem and cerebrospinal fluid studies of corticotropin-releasing factor in humans.
Ann N Y Acad Sci Volume: 780 Page(s): 96 - 105
03/22/1996 Authors: Hartline KM; Owens MJ; Nemeroff CB
Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders.
Proc Natl Acad Sci U S A Volume: 93 Page(s): 1619 - 1623
02/20/1996 Authors: Coplan JD; Andrews MW; Rosenblum LA; Owens MJ; Friedman S; Gorman JM; Nemeroff CB
Augmentation strategies in patients with refractory depression.
Depress Anxiety Volume: 4 Page(s): 169 - 181
01/01/1996 Authors: Nemeroff CB
Molecular and cellular mechanisms of antidepressant drugs.
Depress Anxiety Volume: 4 Page(s): 153 - 159
01/01/1996 Authors: Owens MJ
Peptides and affective disorders
Page(s): 259 - 293
01/01/1996 Authors: Owens MJ; Plotsky PM; Nemeroff CB
Chronic haloperidol-induced changes in regional dopamine release and metabolism and neurotensin content in rats.
Brain Res Volume: 704 Page(s): 202 - 209
12/18/1995 Authors: See RE; Lynch AM; Aravagiri M; Nemeroff CB; Owens MJ
Ontogeny of the effect of antipsychotic drug treatment on neurotensin concentrations in the rat brain.
Synapse Volume: 20 Page(s): 244 - 248
07/01/1995 Authors: Kinkead B; Owens MJ; Nemeroff CB
Regulation of corticotropin-releasing factor secretion and synthesis in the human neuroblastoma clones- BE(2)-M17 and BE(2)-C.
J Neuroendocrinol Volume: 7 Page(s): 461 - 466
06/01/1995 Authors: Kasckow JW; Han JH; Parkes DG; Mulchahey JJ; Owens MJ; Risby ED; Fisher J; Nemeroff CB
Exposure to an antisense oligonucleotide decreases corticotropin-releasing factor receptor binding in rat pituitary cultures.
J Neurochem Volume: 64 Page(s): 2358 - 2361
05/01/1995 Authors: Owens MJ; Mulchahey JJ; Kasckow JW; Plotsky PM; Nemeroff CB
REGULATION OF CRF IN BE (2)-M17 AND BE (2)-C NEUROBLASTOMA CELL-LINES
BIOLOGICAL PSYCHIATRY Volume: 37 Page(s): 647 - 647
05/01/1995 Authors: HAN J; KASCKOW JW; PARKES DG; OWENS MJ; STIPETIC MD; BREITMAN D; KAZANJIAN HL; NEMEROFF CB
The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies.
Life Sci Volume: 57 Page(s): PL373 - PL380
01/01/1995 Authors: Owens MJ; Ieni JR; Knight DL; Winders K; Nemeroff CB
Pharmacogenetics and drug metabolism of newer antidepressant agents.
Volume: 55 Suppl Page(s): 38 - 45
12/01/1994 Authors: DeVane CL
Therapeutic considerations in treating depression in the elderly.
Volume: 55 Suppl Page(s): 48 - 58
12/01/1994 Authors: Dunner DL
Guidelines for the long-term treatment of depression.
Volume: 55 Suppl Page(s): 61 - 69
12/01/1994 Authors: Hirschfeld RM
Recognition and treatment of depression in a primary care setting.
Volume: 55 Suppl Page(s): 18 - 34
12/01/1994 Authors: Montano CB
PHARMACOGENETICS AND DRUG-METABOLISM OF NEWER ANTIDEPRESSANT AGENTS
Volume: 55 Page(s): 38 - 45
12/01/1994 Authors: DEVANE CL
Interleukin-1 alpha induces corticotropin-releasing factor secretion and synthesis from NPLC-KC cells through various second messenger pathways.
Synapse Volume: 18 Page(s): 354 - 358
12/01/1994 Authors: Kasckow JW; Mulcahey JJ; Han JH; Owens MJ; Stipetic MD; Breitman D; Nemeroff CB
Apolipoprotein E epsilon 4.
Neurology Volume: 44 Page(s): 2420 - 2421
12/01/1994 Authors: Rama Krishnan KR; Ritchie JC; Tupler LA; McDonald WM; Knight D; Nemeroff CB; Marcovina S
Evolutionary trends in the pharmacotherapeutic management of depression.
Volume: 55 Suppl Page(s): 3 - 15
12/01/1994 Authors: Nemeroff CB
The effects of typical and atypical antipsychotic drugs on neurotensin-containing neurons in the central nervous system.
J Clin Psychiatry Volume: 55 Suppl B Page(s): 30 - 32
09/01/1994 Authors: Kinkead B; Nemeroff CB
The BE (2)-M17 neuroblastoma cell line synthesizes and secretes corticotropin-releasing factor.
Brain Res Volume: 654 Page(s): 159 - 162
08/15/1994 Authors: Kasckow JW; Parkes DG; Owens MJ; Stipetic MD; Han JH; Nemeroff CB; Vale WW
THE BE(2)-C CELL SECRETES CORTICOTROPIN-RELEASING FACTOR AND RESPONDS TO FORSKOLIN
BIOLOGICAL PSYCHIATRY Volume: 35 Page(s): 663 - 663
05/01/1994 Authors: KASCKOW JW; OWENS MJ; HAN J; STIPETIC MD; NEMEROFF CB
Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.
Clin Chem Volume: 40 Page(s): 288 - 295
02/01/1994 Authors: Owens MJ; Nemeroff CB
Corticotropin-releasing factor is secreted in the BE(2)-C neuroblastoma cell and is responsive to forskolin.
Life Sci Volume: 54 Page(s): 1825 - 1829
01/01/1994 Authors: Kasckow JW; Owens MJ; Stipetic MD; Han JH; Nemeroff CB
Depression and anxiety: role of the locus coeruleus and corticotropin-releasing factor.
Brain Res Bull Volume: 35 Page(s): 561 - 572
01/01/1994 Authors: Weiss JM; Stout JC; Aaron MF; Quan N; Owens MJ; Butler PD; Nemeroff CB
Effects of gender and social isolation on electroencephalogram and neuroendocrine parameters in rats.
Biol Psychiatry Volume: 33 Page(s): 358 - 366
03/01/1993 Authors: Ehlers CL; Kaneko WM; Owens MJ; Nemeroff CB
Potential corticotropin-releasing factor pathways in the rat brain as determined by bilateral electrolytic lesions of the central amygdaloid nucleus and the paraventricular nucleus of the hypothalamus.
J Neuroendocrinol Volume: 5 Page(s): 95 - 98
02/01/1993 Authors: Koegler-Muly SM; Owens MJ; Ervin GN; Kilts CD; Nemeroff CB
THE ROLE OF CORTICOTROPIN-RELEASING FACTOR IN THE PATHOPHYSIOLOGY OF DEPRESSION AND EATING DISORDERS - BASIC AND CLINICAL-STUDIES
Volume: 90 Page(s): 419 - 424
01/01/1993 Authors: OHKUBO Y; OWENS MJ; NEMEROFF CB
The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: implications for a role for CRF in the pathogenesis of anxiety disorders.
J Psychiatr Res Volume: 27 Suppl 1 Page(s): 209 - 220
01/01/1993 Authors: Owens MJ; Vargas MA; Nemeroff CB
Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor.
Psychoneuroendocrinology Volume: 18 Page(s): 485 - 493
01/01/1993 Authors: Pihoker C; Owens MJ; Kuhn CM; Schanberg SM; Nemeroff CB
The role of corticotropin-releasing factor in the pathophysiology of affective and anxiety disorders: laboratory and clinical studies.
Ciba Found Symp Volume: 172 Page(s): 296 - 308
01/01/1993 Authors: Owens MJ; Nemeroff CB
SEROTONIN ANTAGONISTS AS ANTIPSYCHOTICS
Volume: 5 Page(s): 289 - 296
01/01/1993 Authors: KINKEAD BL; OWENS MJ; NEMEROFF CB
Preliminary studies of 6 beta-hydroxydexamethasone and its importance in the DST.
Biol Psychiatry Volume: 32 Page(s): 825 - 833
11/01/1992 Authors: Ritchie JC; Owens MJ; Mayer H; Watson JT; Kilts C; Carroll BJ
Effects of chronic ethanol and benzodiazepine treatment and withdrawal on corticotropin-releasing factor neural systems.
Ann N Y Acad Sci Volume: 654 Page(s): 145 - 152
06/28/1992 Authors: Vargas MA; Bissette G; Owens MJ; Ehlers CL; Nemeroff CB
5 alpha-pregnane-3 alpha, 21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam.
Brain Res Volume: 573 Page(s): 353 - 355
02/28/1992 Authors: Owens MJ; Ritchie JC; Nemeroff CB
THE ROLE OF CORTICOTROPIN-RELEASING FACTOR (CRF) IN THE PATHOGENESIS OF ANXIETY AND AFFECTIVE-DISORDERS - PRECLINICAL AND CLINICAL-STUDIES
Page(s): 915 - 925
01/01/1992 Authors: PIHOKER C; NEMEROFF CB; OWENS MJ; BISSETTE G; WEISS JM; KRISHNAN KRR
EFFECTS OF CHRONIC ETHANOL AND BENZODIAZEPINE TREATMENT AND WITHDRAWAL ON CORTICOTROPIN-RELEASING FACTOR NEURAL SYSTEMS
Volume: 654 Page(s): 145 - 152
01/01/1992 Authors: VARGAS MA; BISSETTE G; OWENS MJ; EHLERS CL; NEMEROFF CB
Stress, corticotropin-releasing factor neurons, and the actions of benzodiazepines.
Clin Neuropharmacol Volume: 15 Suppl 1 Pt A Page(s): 155A - 156A
01/01/1992 Authors: Owens MJ; Nemeroff CB
Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats.
Psychopharmacology (Berl) Volume: 106 Page(s): 359 - 364
01/01/1992 Authors: Ehlers CL; Chaplin RI; Wall TL; Lumeng L; Li TK; Owens MJ; Nemeroff CB
Physiology and pharmacology of corticotropin-releasing factor.
Pharmacol Rev Volume: 43 Page(s): 425 - 473
12/01/1991 Authors: Owens MJ; Nemeroff CB
Subcellular distribution of corticotropin-releasing-factor-like immunoreactivity in rat central nervous system.
Neuroendocrinology Volume: 54 Page(s): 36 - 41
07/01/1991 Authors: Cain ST; Owens MJ; Nemeroff CB
The effects of alprazolam on corticotropin-releasing factor neurons in the rat brain: acute time course, chronic treatment and abrupt withdrawal.
J Pharmacol Exp Ther Volume: 258 Page(s): 349 - 356
07/01/1991 Authors: Owens MJ; Vargas MA; Knight DL; Nemeroff CB
Role for brain corticotropin-releasing factor in the weight-reducing effects of chronic fenfluramine treatment in rats.
Endocrinology Volume: 128 Page(s): 3237 - 3246
06/01/1991 Authors: Appel NM; Owens MJ; Culp S; Zaczek R; Contrera JF; Bissette G; Nemeroff CB; De Souza EB
The 5-hydroxytryptamine2 agonist, (+-)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. I. Acute effects on HPA axis activity and corticotropin-releasing factor-containing neurons in the rat brain.
J Pharmacol Exp Ther Volume: 256 Page(s): 787 - 794
02/01/1991 Authors: Owens MJ; Knight DL; Ritchie JC; Nemeroff CB
The 5-hydroxytryptamine2 agonist, (+-)-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. II. Biochemical and physiological evidence for the development of tolerance after chronic administration.
J Pharmacol Exp Ther Volume: 256 Page(s): 795 - 800
02/01/1991 Authors: Owens MJ; Knight DL; Ritchie JC; Nemeroff CB
Alterations in the hypothalamic-pituitary-adrenal axis in a proposed animal model of depression with genetic muscarinic supersensitivity.
Neuropsychopharmacology Volume: 4 Page(s): 87 - 93
02/01/1991 Authors: Owens MJ; Overstreet DH; Knight DL; Rezvani AH; Ritchie JC; Bissette G; Janowsky DS; Nemeroff CB
NEUROPEPTIDES AND MENTAL-ILLNESS - FOCUS ON AFFECTIVE-DISORDERS
Volume: 968 Page(s): 543 - 545
01/01/1991 Authors: BISSETTE G; OWENS MJ; NEMEROFF CB
Corticotropin-releasing factor concentrations exhibit an apparent diurnal rhythm in hypothalamic and extrahypothalamic brain regions: differential sensitivity to corticosterone.
Neuroendocrinology Volume: 52 Page(s): 626 - 631
12/01/1990 Authors: Owens MJ; Bartolome J; Schanberg SM; Nemeroff CB
Effects of 5-HT1A receptor agonists on hypothalamo-pituitary-adrenal axis activity and corticotropin-releasing factor containing neurons in the rat brain.
Eur J Pharmacol Volume: 190 Page(s): 113 - 122
11/06/1990 Authors: Owens MJ; Edwards E; Nemeroff CB
Ecological toxicology and human health effects of heptachlor.
Rev Environ Contam Toxicol Volume: 111 Page(s): 61 - 142
01/01/1990 Authors: Fendick EA; Mather-Mihaich E; Houck KA; St Clair MB; Faust JB; Rockwell CH; Owens M
Growth hormone response to growth hormone releasing factor in Alzheimer's disease.
Neuroendocrinology Volume: 50 Page(s): 663 - 666
12/01/1989 Authors: Nemeroff CB; Krishnan KR; Belkin BM; Ritchie JC; Clark C; Vale WW; Rivier JE; Thorner MO
Acute effects of alprazolam and adinazolam on the concentrations of corticotropin-releasing factor in the rat brain.
Synapse Volume: 4 Page(s): 196 - 202
01/01/1989 Authors: Owens MJ; Bissette G; Nemeroff CB
Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims.
Arch Gen Psychiatry Volume: 45 Page(s): 577 - 579
06/01/1988 Authors: Nemeroff CB; Owens MJ; Bissette G; Andorn AC; Stanley M
Preclinical and clinical studies with corticotropin-releasing factor: implications for affective disorders.
Psychopharmacol Bull Volume: 24 Page(s): 355 - 359
01/01/1988 Authors: Owens MJ; Nemeroff CB

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Michael Owens PhD

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