Mohd Khan

Department of Orthopaedics
Assistant Professor

Atlanta VA Medical Center
Orthopaedics
1670 Clairmont Circle
Emory Musculoskeletal Institute
Orthopaedics
21 Ortho Lane

Overview

I have keen interest in understanding the molecular pathogenesis of osteoarthritis (OA) and identifying and targeting potential therapeutic targets to stop/delay the joint inflammation, and cartilage destruction to restore joint function. We used several research tools employing cellular, molecular, biochemical, high throughput sequencing and system biology approach in the in vitro cell culture model and in vivo genetic animal models. My research discovered the role of an orphan GPCR as a novel regulator of inflammation and apoptosis in OA. Using CRISPR/Cas9 based genome editing and long-range interaction mapping by 4C-sequencing in stem cells (iPSCs), we have identified the role of regulatory sequences within intronic region of RUNX1 locus for skeletal cell differentiation and bone formation using Calvarial defect model in mice. My other research focus involved regenerative medicine approach for cartilage preservation, repair and regeneration of joint tissue using stem cells (MSCs) in various model of post-traumatic osteoarthritis (PTOA) in mice and rats.

Academic Appointment

Assistant Professor, Orthopaedics, Emory University
Research Scientist, Orthopaedics, Atlanta VA Medical Center

Education

Degrees

Ph.D. from Bhabha Atomic Research Centre

Research

Publications

Kartogenin Enhances Chondrogenic Differentiation of iPSC Derived MSCs (iMSCs) and Improves Outcomes in an Osteochondral Defect Model in Male Rats.
J Orthop Res Volume: 43 Page(s): 870 - 880
04/01/2025 Authors: Chihab S; Khan NM; Eng T; Doan T; Kaiser JM; Drissi H
Dimethyl Fumarate attenuates synovial inflammation, reduces nociception, and inhibits the development of post-traumatic osteoarthritis.
Biomed Pharmacother Volume: 183 Page(s): 117865
02/01/2025 Authors: Khan NM; Kaiser JM; Chihab S; Eng T; Drissi H
Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene.
Bone Res Volume: 12 Page(s): 70
12/06/2024 Authors: Khan NM; Wilderman A; Kaiser JM; Kamalakar A; Goudy SL; Cotney J; Drissi H
Early signs of osteoarthritis in differing rat osteochondral defects.
J Orthop Res Volume: 42 Page(s): 2461 - 2472
11/01/2024 Authors: Chihab S; Eng T; Kaiser JM; Khan NM; Doan TN; Drissi H
Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs.
Cells Volume: 13
09/04/2024 Authors: Diaz-Hernandez ME; Murakami K; Murata S; Khan NM; Shenoy SPV; Henke K; Yamada H; Drissi H
Efficient Differentiation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Mesenchymal Progenitors Into Adipocytes and Osteoblasts.
Bio Protoc Volume: 13 Page(s): e4885
11/20/2023 Authors: Diaz-Hernandez ME; Khan NM; Drissi H
Differentiation of Human Induced Pluripotent Stem Cells (iPSCs)-derived Mesenchymal Progenitors into Chondrocytes.
Bio Protoc Volume: 13 Page(s): e4874
11/05/2023 Authors: Khan NM; Diaz-Hernandez ME; Drissi H
DIMETHYL FUMARATE AS A POTENTIAL DISEASE MODIFYING AGENT FOR THE TREATMENT OF KNEE OSTEOARTHRITIS
Volume: 31 Page(s): S337 - S337
03/01/2023 Authors: Khan NM; Kaiser J; Diaz-Hernandez ME; Chihab S; Eng T; Drissi H
Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures.
Elife Volume: 12
01/30/2023 Authors: Khan NM; Diaz-Hernandez ME; Chihab S; Priyadarshani P; Bhattaram P; Mortensen LJ; Guzzo RM; Drissi H
pH-sensing G protein-coupled orphan receptor GPR68 is expressed in human cartilage and correlates with degradation of extracellular matrix during OA progression.
PeerJ Volume: 11 Page(s): e16553
01/01/2023 Authors: Khan NM; Diaz-Hernandez ME; Martin WN; Patel B; Chihab S; Drissi H
PHLPP1 deficiency protects against age-related intervertebral disc degeneration.
JOR Spine Volume: 5 Page(s): e1224
12/01/2022 Authors: Zhang C; Joseph KM; Khan NM; Diaz-Hernandez ME; Drissi H; Illien-Junger S
Sexually Dimorphic Increases in Bone Mass Following Tissue-specific Overexpression of Runx1 in Osteoclast Precursors.
Endocrinology Volume: 163
09/01/2022 Authors: Daz-Hernndez ME; Kinter CW; Watson SR; Mella-Velazquez G; Kaiser J; Liu G; Khan NM; Roberts JL; Lorenzo J; Drissi H
Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells.
Sci Rep Volume: 10 Page(s): 15263
09/17/2020 Authors: Fernandes LM; Khan NM; Trochez CM; Duan M; Diaz-Hernandez ME; Presciutti SM; Gibson G; Drissi H
Network Analysis Identifies Gene Regulatory Network Indicating the Role of RUNX1 in Human Intervertebral Disc Degeneration.
Genes (Basel) Volume: 11
07/09/2020 Authors: Khan NM; Diaz-Hernandez ME; Presciutti SM; Drissi H
Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell-transcriptomics.
J Cell Physiol Volume: 235 Page(s): 5241 - 5255
06/01/2020 Authors: Diaz-Hernandez ME; Khan NM; Trochez CM; Yoon T; Maye P; Presciutti SM; Gibson G; Drissi H
Genetic Inactivation of ZCCHC6 Suppresses Interleukin-6 Expression and Reduces the Severity of Experimental Osteoarthritis in Mice.
Arthritis Rheumatol Volume: 71 Page(s): 583 - 593
04/01/2019 Authors: Ansari MY; Khan NM; Ahmad N; Green J; Novak K; Haqqi TM
Parkin clearance of dysfunctional mitochondria regulates ROS levels and increases survival of human chondrocytes.
Osteoarthritis Cartilage Volume: 26 Page(s): 1087 - 1097
08/01/2018 Authors: Ansari MY; Khan NM; Ahmad I; Haqqi TM
ZCCHC5, A LTR RETROTRANSPOSON-DERIVED NEOFUNCTIONALIZED GENE, IS ESSENTIAL FOR THE TRANSCRIPTIONAL ACTIVITY OF SOX9 AND THE EXPRESSION OF COL2A1 IN CHONDROCYTES AND IS DOWNREGULATED IN OA CARTILAGE
Volume: 77 Page(s): 179 - 179
06/01/2018 Authors: Haqqi TM; Khan NM
A NEOFUNCTIONALIZED GENE ZCCHC5 IS EXPRESSED IN CARTILAGE AND ITS DOWNREGULATION INHIBITS COL2A1 EXPRESSION AND ENHANCES THE EXPRESSION OF MMP-13 IN CHONDROCYTES
Volume: 26 Page(s): S131 - S131
04/01/2018 Authors: Khan NM; Haqqi TM
ZCCHC6 (TUT7) DELETION INHIBIT THE EXPRESSION OF IL-6 AND MMP-13 AND REDUCES THE SEVERITY OF POST-TRAUMATIC OSTEOARTHRITIS IN A MURINE MODEL
Volume: 26 Page(s): S97 - S98
04/01/2018 Authors: Ansari MY; Khan NM; Haqqi TM
LIN28A IS OVEREXPRESSED IN OSTEOARTHRITIS AND IS ESSENTIAL FOR THE STABILITY AND HIGH LEVEL EXPRESSION OF IL-6 AND COX-2 IN HUMAN CHONDROCYTES
Volume: 26 Page(s): S92 - S93
04/01/2018 Authors: Ahmad I; Ansari MY; Khan NM; Haqqi TM
HUMAN CHONDROCYTES WITH OXIDATIVE AND ER STRESS INHIBIT PROTEIN SYNTHESIS BY INDUCTION OF TRNA FRAGMENTS FROM A SUBSET OF TRNA ISOTYPES INDEPENDENT OF ANGIOGENIN EXPRESSION AND ACTIVITY
Volume: 26 Page(s): S162 - S163
04/01/2018 Authors: Green J; Khan NM; Ansari MY; Ahmad I; Novak K; Haqqi TM
Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.
Free Radic Biol Med Volume: 116 Page(s): 159 - 171
02/20/2018 Authors: Khan NM; Ahmad I; Haqqi TM
Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeutics.
Pharmacol Res Volume: 128 Page(s): 73 - 79
02/01/2018 Authors: Khan NM; Haqqi TM
A standardized extract of Butea monosperma (Lam.) flowers suppresses the IL-1-induced expression of IL-6 and matrix-metalloproteases by activating autophagy in human osteoarthritis chondrocytes.
Biomed Pharmacother Volume: 96 Page(s): 198 - 207
12/01/2017 Authors: Ansari MY; Khan NM; Haqqi TM
Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes.
Sci Rep Volume: 7 Page(s): 15178
11/09/2017 Authors: Haseeb A; Makki MS; Khan NM; Ahmad I; Haqqi TM
Pleiotropic Roles of Nrf2 as Regulators of Chondrocyte Apoptosis, Oxidative Stress, Inflammatory Response and Catabolic and Anabolic Pathways in Osteoarthritis
Volume: 112 Page(s): 191 - 191
11/01/2017 Authors: Khan NM; Haqqi TM
Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1 stimulated osteoarthritis chondrocytes.
Chem Biol Interact Volume: 274 Page(s): 13 - 23
08/25/2017 Authors: Khan NM; Ahmad I; Ansari MY; Haqqi TM
Dataset of effect of Wogonin, a natural flavonoid, on the viability and activation of NF-B and MAPKs in IL-1-stimulated human OA chondrocytes.
Data Brief Volume: 12 Page(s): 150 - 155
06/01/2017 Authors: Khan NM; Haseeb A; Ansari MY; Devarapalli P; Haynie S; Haqqi TM
Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes.
Free Radic Biol Med Volume: 106 Page(s): 288 - 301
05/01/2017 Authors: Khan NM; Haseeb A; Ansari MY; Devarapalli P; Haynie S; Haqqi TM
A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-B and IL-6 Expression by Blocking the Activation of IKK and NIK in Primary Human Chondrocytes.
Phytother Res Volume: 31 Page(s): 778 - 782
05/01/2017 Authors: Haseeb A; Khan NM; Ashruf OS; Haqqi TM
WOGONIN EXERTS ANTI-INFLAMMATORY EFFECT BY DISRUPTING KEAP-1/NRF2 INTERACTIONS AND ACTIVATING NRF2 IN HUMAN OA CHONDROCYTES
Volume: 25 Page(s): S82 - S83
04/01/2017 Authors: Khan NM; Ansari MY; Haynie S; Haqqi TM
ELIMINATION OF DYSFUNCTIONAL MITOCHONDRIA BY PARKIN SUPPRESSES OXIDATIVE STRESS AND EXPRESSION OF OSTEOARTHRITIS RELATED GENES IN HUMAN CHONDROCYTES
Volume: 25 Page(s): S44 - S45
04/01/2017 Authors: Ansari MY; Khan NM; Ahmad I; Haqqi TM
A WOGONIN-RICH FRACTION OF SCUTELLARIA BAICALENSIS ROOT EXTRACT EXERTS CHONDROPROTECTIVE EFFECTS BY SUPPRESSING IL-1 beta-INDUCED ACTIVATION OF AP-1 IN HUMAN OA CHONDROCYTES
Volume: 25 Page(s): S292 - S292
04/01/2017 Authors: Khan NM; Haseeb A; Ansari MY; Haqqi TM
WOGONIN EXERTS ANTI-INFLAMMATORY EFFECT BY DISRUPTING KEAP-1/NRF2 INTERACTIONS AND ACTIVATING NRF2 IN HUMAN OA CHONDROCYTES
Volume: 25 Page(s): S31 - S31
04/01/2017 Authors: Khan NM; Ansari MY; Haynie S; Haqqi TM
A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1-induced activation of AP-1 in human OA chondrocytes.
Sci Rep Volume: 7 Page(s): 43789
03/03/2017 Authors: Khan NM; Haseeb A; Ansari MY; Haqqi TM
Sucrose, But Not Glucose, Blocks IL1--Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway.
J Cell Biochem Volume: 118 Page(s): 629 - 639
03/01/2017 Authors: Khan NM; Ansari MY; Haqqi TM
Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.
Nutrition Volume: 33 Page(s): 1 - 13
01/01/2017 Authors: Akhtar N; Khan NM; Ashruf OS; Haqqi TM
Directional dominance on stature and cognition indiverse human populations.
Nature Volume: 523 Page(s): 459 - 462
07/23/2015 Authors: Joshi PK; Esko T; Mattsson H; Eklund N; Gandin I; Nutile T; Jackson AU; Schurmann C; Smith AV; Zhang W
Genetic epidemiology of pharmacogenetic variations in CYP2C9, CYP4F2 and VKORC1 genes associated with warfarin dosage in the Indian population.
Pharmacogenomics Volume: 15 Page(s): 1337 - 1354
07/01/2014 Authors: Giri AK; Khan NM; Grover S; Kaur I; Basu A; Tandon N; Scaria V; Consortium IGV; INDICO; Kukreti R
Pharmacogenetic landscape of clopidogrel in north Indians suggest distinct interpopulation differences in allele frequencies.
Pharmacogenomics Volume: 15 Page(s): 643 - 653
04/01/2014 Authors: Giri AK; Khan NM; Basu A; Tandon N; Scaria V; Bharadwaj D
Antioxidant supplementation enhances bacterial peritonitis in mice by inhibiting phagocytosis.
J Med Microbiol Volume: 63 Page(s): 355 - 366
03/01/2014 Authors: Goswami M; Sharma D; Khan NM; Checker R; Sandur SK; Jawali N
Current challenges to overcome in the management of type 2 diabetes mellitus and associated neurological disorders.
CNS Neurol Disord Drug Targets Volume: 13 Page(s): 1440 - 1457
01/01/2014 Authors: Khan NM; Ahmad A; Tiwari RK; Kamal MA; Mushtaq G; Ashraf GM
Bilirubin augments radiation injury and leads to increased infection and mortality in mice: molecular mechanisms.
Free Radic Biol Med Volume: 53 Page(s): 1152 - 1169
09/01/2012 Authors: Khan NM; Poduval TB
Differential immunotoxic effects of ethanol on murine EL-4 lymphoma and normal lymphocytes is mediated through increased ROS production and activation of p38MAPK.
Immunopharmacol Immunotoxicol Volume: 34 Page(s): 616 - 626
08/01/2012 Authors: Premachandran S; Khan NM; Thakur VS; Shukla J; Poduval TB
Immunomodulatory and immunotoxic effects of bilirubin: molecular mechanisms.
J Leukoc Biol Volume: 90 Page(s): 997 - 1015
11/01/2011 Authors: Khan NM; Poduval TB
L-arginine mitigates radiation-induced early changes in cardiac dysfunction: the role of inflammatory pathways.
Radiat Res Volume: 176 Page(s): 158 - 169
08/01/2011 Authors: Shukla J; Khan NM; Thakur VS; Poduval TB
Vitamin K3 suppressed inflammatory and immune responses in a redox-dependent manner.
Free Radic Res Volume: 45 Page(s): 975 - 985
08/01/2011 Authors: Checker R; Sharma D; Sandur SK; Khan NM; Patwardhan RS; Kohli V; Sainis KB
Role of immunoregulatory transcription factors in differential immunomodulatory effects of tocotrienols.
Free Radic Biol Med Volume: 51 Page(s): 129 - 143
07/01/2011 Authors: Wilankar C; Sharma D; Checker R; Khan NM; Patwardhan R; Patil A; Sandur SK; Devasagayam TPA
Pro-oxidants ameliorate radiation-induced apoptosis through activation of the calcium-ERK1/2-Nrf2 pathway.
Free Radic Biol Med Volume: 51 Page(s): 115 - 128
07/01/2011 Authors: Khan NM; Sandur SK; Checker R; Sharma D; Poduval TB; Sainis KB
-Tocotrienol induces apoptosis in human T cell lymphoma through activation of both intrinsic and extrinsic pathways.
Curr Pharm Des Volume: 17 Page(s): 2176 - 2189
01/01/2011 Authors: Wilankar C; Khan NM; Checker R; Sharma D; Patwardhan R; Gota V; Sandur SK; Devasagayam TPA

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