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Profile

Mark Nanes MD/PhD

  • Department of Medicine
    Professor Emeritus
  • mark.nanes@emory.edu
Head shot of Mark Nanes

Overview

Dr. Mark Nanes is professor of medicine at Emory University. Dr. Nanes received a BA at Clark University and PhD, MD at Case Western Reserve University in Cleveland. His graduate work in reproductive endocrinology focused on prolactin regulation of corpus luteum function in the laboratory of Dr. Irving Rothchild and later the study of extra renal production of vitamin D 1-alpha hydroxylase in decidual tissue and placenta. Dr. Nanes completed his internal medicine residency at University Hospitals, Case Western Reserve University. Following residency, Dr. Nanes trained in Endocrinology as a medical staff fellow in the Metabolic Diseases Branch at the National Institutes of Health. He worked with Dr. Stephen Marx and developed an interest in the pathophysiology of inflammatory cytokines in skeletal disorders.

Dr. Nanes joined the faculty at Emory University in 1988. He was program director of the Emory Endocrinology Fellowship Training Program. At the VA Medical Center, Dr. Nanes served as chief of the Endocrine Section and assistant chief of Subspecialty Medicine prior to his appointment as Chief of Medicine. Dr. Nanes stepped down from his position as Chief of Medicine at the VA in 2016.

Dr. Nanes has served as a member of the NIH Skeletal Biology Structure and Regeneration Study Section and the Department of Veterans Affairs Merit Review Board in Endocrinology. He is a past editorial board member for Endocrinology and the Journal of Bone and Mineral Research and is an ad hoc reviewer for a variety of endocrinology and bone journals. Dr. Nanes research focuses on the inflammatory cytokine TNF as a mediator of skeletal disease. TNF contributes to bone loss by targeting the differentiation, function, and lifespan of bone cells and by causing acquired resistance to vitamin D. His most recent projects evaluate cytokine modulation of signal pathways in bone cell differentiation and function. As Chief of Specialty Medicine at the VA Medical Center, Dr. Nanes faces the challenge of delivering quality care to a burgeoning patient population, the expansion of subspecialty services, enhancement of the Emory Medical residency program, and establishing a new VA dual affiliation with both Emory and Morehouse Schools of Medicine.

Academic Appointment

  • Professor of Medicine, Emory University School of Medicine
  • Assistant Professor of Medicine, Emory University School of Medicine

Education

Degrees

  • MD from Case Western Reserve University
  • AB from Clark University
  • PhD from Case Western Reserve University

Research

Publications

  • Disseminated Cryptococcosis in An Immunocompetent Host Presenting As Osteomyelitis and Leading to Adrenal Insufficiency.
    Am J Med Sci Volume: 363 Page(s): 75 - 79
    01/01/2022 Authors: Hsu E; Webster SM; Nanes M
  • Advances in treatment of glucocorticoid-induced osteoporosis.
    Curr Opin Endocrinol Diabetes Obes Volume: 24 Page(s): 411 - 417
    12/01/2017 Authors: Hsu E; Nanes M
  • From Vascular Access to Adrenal Axis: Pre-endoscopic Management of MEN-2B Syndrome
    Volume: 112 Page(s): S983 - S983
    10/01/2017 Authors: Van Leer-Greenberg B; Haydek JP; Berger S; Goebel S; Nanes M
  • Systolic Blood Pressure Control Among Individuals With Type 2 Diabetes: A Comparative Effectiveness Analysis of Three Interventions.
    Am J Hypertens Volume: 28 Page(s): 995 - 1009
    08/01/2015 Authors: Espeland MA; Probstfield J; Hire D; Redmon JB; Evans GW; Coday M; Lewis CE; Johnson KC; Wilmoth S; Bahnson J
  • Progesterone and Src family inhibitor PP1 synergistically inhibit cell migration and invasion of human basal phenotype breast cancer cells.
    Biomed Res Int Volume: 2015 Page(s): 426429
    01/01/2015 Authors: Xie M; Zhou L; Chen X; Gainey LO; Xiao J; Nanes MS; Hou A; You S; Chen Q
  • Osteocyte differentiation is delayed by low dose TNF.
    Volume: 29 Page(s): S433 - S433
    02/01/2014 Authors: Nanes M; Gilbert L
  • Osteoporosis.
    Semin Nucl Med Volume: 44 Page(s): 439 - 450
    01/01/2014 Authors: Nanes MS; Kallen CB
  • Phosphate wasting and fibroblast growth factor-23.
    Curr Opin Endocrinol Diabetes Obes Volume: 20 Page(s): 523 - 531
    12/01/2013 Authors: Nanes MS
  • Chronic low dose tumor necrosis factor- (TNF) suppresses early bone accrual in young mice by inhibiting osteoblasts without affecting osteoclasts.
    Bone Volume: 56 Page(s): 174 - 183
    09/01/2013 Authors: Gilbert LC; Chen H; Lu X; Nanes MS
  • Prx-1 Coverts MAPK Regulation of Osterix Transcription from Stimulation to Inhibition
    Volume: 28
    02/01/2013 Authors: Gilbert L; Nanes M
  • A new regulator of osteoclastogenesis: estrogen response element-binding protein in bone.
    J Bone Miner Res Volume: 26 Page(s): 2537 - 2547
    10/01/2011 Authors: Chen H; Gilbert LC; Lu X; Liu Z; You S; Weitzmann MN; Nanes MS; Adams J
  • Fracture assessment tool risk scores in bone density reports do not change physician prescribing behavior for osteoporosis.
    Am J Med Sci Volume: 342 Page(s): 5 - 8
    07/01/2011 Authors: Izuora KE; Alazraki N; Byrd-Sellers J; Tangpricha V; Nanes MS
  • Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor action in osteoblast differentiation.
    J Bone Miner Res Volume: 26 Page(s): 209 - 219
    01/01/2011 Authors: Lu X; Beck GR; Gilbert LC; Camalier CE; Bateman NW; Hood BL; Conrads TP; Kern MJ; You S; Chen H
  • PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B.
    Am J Physiol Lung Cell Mol Physiol Volume: 299 Page(s): L559 - L566
    10/01/2010 Authors: Lu X; Murphy TC; Nanes MS; Hart CM
  • Vitamin D-mediated calcium absorption in patients with clinically stable Crohn's disease: a pilot study.
    Mol Nutr Food Res Volume: 54 Page(s): 1085 - 1091
    08/01/2010 Authors: Kumari M; Khazai NB; Ziegler TR; Nanes MS; Abrams SA; Tangpricha V
  • FRAX Fails To Change Prescribing Behavior Despite Increased Recommendation To Treat.
    Volume: 31
    06/01/2010 Authors: Izuora KE; Alazraki N; Byrd-Sellers J; Tangpricha V; Nanes MS
  • Hypoxia downregulates peroxisome proliferator-activated receptor-gamma in human pulmonary artery smooth muscle cells by NF-kappa B and ERK1/2
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Lu X; Ramirez A; Nanes M; Hart CM
  • PPAR gamma regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-kappa B
    FASEB JOURNAL Volume: 24
    04/01/2010 Authors: Lu X; Murphy T; Nanes M; Hart CM
  • Preventing metastases to bone: denosumab or bisphosphonates?
    J Bone Miner Res Volume: 25 Page(s): 437 - 439
    03/01/2010 Authors: Nanes MS
  • FRAX FAILS TO CHANGE PRESCRIBING BEHAVIOR DESPITE INCREASED RECOMMENDATION TO TREAT
    Volume: 58 Page(s): 449 - 449
    02/01/2010 Authors: Izuora KE; Alazraki N; Byrd-Sellers J; Tangpricha V; Nanes MS
  • Regulation of osterix (Osx, Sp7) and the Osx promoter by parathyroid hormone in osteoblasts.
    J Mol Endocrinol Volume: 43 Page(s): 197 - 207
    11/01/2009 Authors: Hong SHH; Lu X; Nanes MS; Mitchell J
  • T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling.
    Cell Metab Volume: 10 Page(s): 229 - 240
    09/01/2009 Authors: Terauchi M; Li J-Y; Bedi B; Baek K-H; Tawfeek H; Galley S; Gilbert L; Nanes MS; Zayzafoon M; Guldberg R
  • Clinical assessment of fracture risk and novel therapeutic strategies to combat osteoporosis.
    Fertil Steril Volume: 92 Page(s): 403 - 412
    08/01/2009 Authors: Nanes MS; Kallen CB
  • Evaluation of vitamin D repletion regimens to correct vitamin D status in adults.
    Endocr Pract Volume: 15 Page(s): 95 - 103
    03/01/2009 Authors: Pepper KJ; Judd SE; Nanes MS; Tangpricha V
  • Evidence of a Role for the Human Vitamin D Response Element Binding Protein, Heterogeneous Nuclear Ribonucleoprotein (hnRNP) C1/C2 in Chromatin Remodeling and Transcript Splicing
    Volume: 23 Page(s): S105 - S105
    09/01/2008 Authors: Chen H; Hewison M; Nanes M; Adams JS
  • T Cells Amplify The Anabolic Action of PTH Through Wnt10b Signaling
    Volume: 23 Page(s): S56 - S56
    09/01/2008 Authors: Terauchi M; Nanes MS; Weitzmann M; Zayafoon M; Weitzmann M; Lane TF; Pacifici R
  • Parathyroid Hormone Regulation of Osterix Transcription in Osteoblasts.
    Volume: 23 Page(s): S384 - S384
    09/01/2008 Authors: Hong SHH; Nanes MS; Mitchell J
  • The muscle transcription factor MyoD promotes osteoblast differentiation by stimulation of the Osterix promoter.
    Endocrinology Volume: 149 Page(s): 3698 - 3707
    07/01/2008 Authors: Hewitt J; Lu X; Gilbert L; Nanes MS
  • Effects of intensive glucose lowering in type 2 diabetes.
    N Engl J Med Volume: 358 Page(s): 2545 - 2559
    06/12/2008 Authors: Action to Control Cardiovascular Risk in Diabetes Study Group; Gerstein HC; Miller ME; Byington RP; Goff DC; Bigger JT; Buse JB; Cushman WC; Genuth S; Ismail-Beigi F
  • Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey.
    Am J Clin Nutr Volume: 87 Page(s): 136 - 141
    01/01/2008 Authors: Judd SE; Nanes MS; Ziegler TR; Wilson PWF; Tangpricha V
  • Identification of the homeobox protein, Prx1 (MHox), as a regulator of osterix expression and mediator of TNF action.
    Volume: 22 Page(s): S41 - S41
    09/01/2007 Authors: Lu X; Beck GR; Gilbert LC; Conrads TP; Kern MJ; Nanes MS
  • Vitamin D status is inversely associated with blood pressure: Results from the third National Health and Nutrition Examination Survey
    Volume: 22 Page(s): S222 - S222
    09/01/2007 Authors: Judd SE; Blanck HM; Nanes MS; Zieler TR; Wilson PWF; Tangpricha V
  • Endogenous TNF alpha lowers maximum peak bone mass and inhibits osteoblastic smad activation through NF-kappa B (vol 22, pg 646, 2007)
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 22 Page(s): 949 - 949
    06/01/2007 Authors: Li Y; Li A; Strait K; Zhang H; Nanes MS; Weitzmann MN
  • Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kappaB.
    J Bone Miner Res Volume: 22 Page(s): 646 - 655
    05/01/2007 Authors: Li Y; Li A; Strait K; Zhang H; Nanes MS; Weitzmann MN
  • Bone re/modeling is more dynamic in the endothelial nitric oxide synthase(-/-) mouse.
    Endocrinology Volume: 147 Page(s): 4392 - 4399
    09/01/2006 Authors: Grassi F; Fan X; Rahnert J; Weitzmann MN; Pacifici R; Nanes MS; Rubin J
  • TNF lowers maximum achievable peak bone mass by downregulating TGF beta and BMP-2 induced smad signaling through a mechanism involving NF-kappa B.
    Volume: 21 Page(s): S158 - S158
    09/01/2006 Authors: Li Y; Li A; Nanes MS; Weitzmann MN
  • A role for nitric oxide in the mechanical regulation of RANKL in bone stromal cells.
    Volume: 21 Page(s): S73 - S73
    09/01/2006 Authors: Fan X; Rahnert J; Case N; Murphy TC; Grassi F; Nanes MS; Rubin J
  • IGF-I secretion by prostate carcinoma cells does not alter tumor-bone cell interactions in vitro or in vivo.
    Prostate Volume: 66 Page(s): 789 - 800
    06/01/2006 Authors: Rubin J; Fan X; Rahnert J; Sen B; Hsieh C-L; Murphy TC; Nanes MS; Horton LG; Beamer WG; Rosen CJ
  • Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2.
    J Cell Physiol Volume: 207 Page(s): 454 - 460
    05/01/2006 Authors: Fan X; Rahnert JA; Murphy TC; Nanes MS; Greenfield EM; Rubin J
  • Transcriptional regulation of the osterix (Osx, Sp7) promoter by tumor necrosis factor identifies disparate effects of mitogen-activated protein kinase and NF kappa B pathways.
    J Biol Chem Volume: 281 Page(s): 6297 - 6306
    03/10/2006 Authors: Lu X; Gilbert L; He X; Rubin J; Nanes MS
  • Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase.
    J Biol Chem Volume: 281 Page(s): 1412 - 1418
    01/20/2006 Authors: Rubin J; Murphy TC; Rahnert J; Song H; Nanes MS; Greenfield EM; Jo H; Fan X
  • Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase in a lipid raft dependent manner.
    Volume: 20 Page(s): S73 - S73
    09/01/2005 Authors: Rubin J; Murphy TC; Rahnert J; Nanes MS; Greenfield EM; Jo H; Fan X
  • Canonical Wnt signaling is inhibited by tumor necrosis factor-alpha
    Volume: 20 Page(s): S244 - S244
    09/01/2005 Authors: Lu X; Gilbert LC; Rubin J; Nanes MS
  • Inhibition of osteoblast differentiation by TNF requires mitogen activated protein kinase.
    Volume: 20 Page(s): S245 - S245
    09/01/2005 Authors: Gilbert LC; Lu X; Rubin J; Nanes MS
  • Mechanical strain regulates effectors of both formation and resorption in an immortalized osteoblast cell line.
    Volume: 20 Page(s): S239 - S240
    09/01/2005 Authors: Fan X; Rahnert JA; Murphy TC; Nanes MS; Greenfield EM; Rubin J
  • The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis.
    Am J Physiol Endocrinol Metab Volume: 288 Page(s): E1011 - E1018
    05/01/2005 Authors: Gilbert LC; Rubin J; Nanes MS
  • Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells.
    J Cell Biochem Volume: 93 Page(s): 807 - 818
    11/01/2004 Authors: Fan X; Roy EM; Murphy TC; Nanes MS; Kim S; Pike JW; Rubin J
  • Tumor necrosis factor inhibition of the osterix promoter
    Volume: 19 Page(s): S406 - S406
    10/01/2004 Authors: Lu X; He X; Rubin J; Nanes MS
  • Specific activation of the H-Ras isoform is required for mechanical strain inhibition of RANKL.
    Volume: 19 Page(s): S10 - S10
    10/01/2004 Authors: Rubin J; Murphy TC; Rahnert J; Nanes MS; Fan X
  • Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells
    Volume: 19 Page(s): S262 - S262
    10/01/2004 Authors: Fan X; Roy EM; Murphy TC; Nanes MS; Kim S; Pike J; Rubin J
  • Integration of the NfkappaB p65 subunit into the vitamin D receptor transcriptional complex: identification of p65 domains that inhibit 1,25-dihydroxyvitamin D3-stimulated transcription.
    J Cell Biochem Volume: 92 Page(s): 833 - 848
    07/01/2004 Authors: Lu X; Farmer P; Rubin J; Nanes MS
  • Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells.
    Endocrinology Volume: 145 Page(s): 751 - 759
    02/01/2004 Authors: Fan X; Roy E; Zhu L; Murphy TC; Ackert-Bicknell C; Hart CM; Rosen C; Nanes MS; Rubin J
  • Prostate carcinoma cells that have resided in bone have an upregulated IGF-I axis.
    Prostate Volume: 58 Page(s): 41 - 49
    01/01/2004 Authors: Rubin J; Chung LWK; Fan X; Zhu L; Murphy TC; Nanes MS; Rosen CJ
  • Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology.
    Gene Volume: 321 Page(s): 1 - 15
    12/04/2003 Authors: Nanes MS
  • Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK.
    J Biol Chem Volume: 278 Page(s): 34018 - 34025
    09/05/2003 Authors: Rubin J; Murphy TC; Zhu L; Roy E; Nanes MS; Fan X
  • Nitric oxide regulates RANKL and OPG expression in bone stromal cells.
    Volume: 18 Page(s): S338 - S339
    09/01/2003 Authors: Fan X; Roy E; Zhu L; Murphy TC; Hart M; Rosen CJ; Nanes MS; Rubin J
  • Mechanical strain differentially regulates eNOS and RANKL expression via ERK1/2 in primary bone stromal cells
    Volume: 18 Page(s): S10 - S11
    09/01/2003 Authors: Rubin J; Murphy TC; Zhu L; Roy E; Nanes MS; Fan X
  • Inhibition of osteoblast differentiation by TNF-alpha is associated with suppression of osterix expression.
    Volume: 18 Page(s): S223 - S223
    09/01/2003 Authors: Gilbert LC; He X; Kauppi A; Rubin J; Nanes MS
  • NF kappa B suppression of VDR transactivation requires the rel homology domain of p65.
    Volume: 18 Page(s): S101 - S101
    09/01/2003 Authors: Lu X; Fiester P; Rubin J; Nanes MS
  • Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion.
    J Biol Chem Volume: 278 Page(s): 10232 - 10238
    03/21/2003 Authors: Fan X; Roy E; Zhu L; Murphy TC; Kozlowski M; Nanes MS; Rubin J
  • Hypercalcemia in hyperthyroidism: patterns of serum calcium, parathyroid hormone, and 1,25-dihydroxyvitamin D3 levels during management of thyrotoxicosis.
    Endocr Pract Volume: 9 Page(s): 517 - 521
    01/01/2003 Authors: Iqbal AA; Burgess EH; Gallina DL; Nanes MS; Cook CB
  • Nf kappa B suppression of VDR transactivation is not due to competition for p160 nuclear proteins.
    Volume: 17 Page(s): S495 - S495
    09/01/2002 Authors: Lu X; Sepp HW; He X; Farmer P; Rubin J; Nanes MS
  • The RANKL promoter is activated through acetylation.
    Volume: 17 Page(s): S245 - S245
    09/01/2002 Authors: Rubin J; Murphy TC; Zhu L; Pike JW; Nanes MS; Fan X
  • Bone microenvironment triggers IGF-1 release from prostate carcinoma.
    Volume: 17 Page(s): S148 - S148
    09/01/2002 Authors: Rubin J; Chung L; Fan X; Zhu L; Murphy TC; Nanes MS; Rosen CJ
  • The P55 TNF receptor mediates TNF inhibition of osteoblast differentiation.
    Volume: 17 Page(s): S338 - S338
    09/01/2002 Authors: Gilbert L; Brantley A; Rubin J; Nanes MS
  • IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo.
    J Clin Endocrinol Metab Volume: 87 Page(s): 4273 - 4279
    09/01/2002 Authors: Rubin J; Ackert-Bicknell CL; Zhu L; Fan X; Murphy TC; Nanes MS; Marcus R; Holloway L; Beamer WG; Rosen CJ
  • Osteoporosis in men: pathophysiology, evaluation, and therapy.
    Curr Opin Rheumatol Volume: 14 Page(s): 421 - 428
    07/01/2002 Authors: Burgess E; Nanes MS
  • Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha.
    J Biol Chem Volume: 277 Page(s): 2695 - 2701
    01/25/2002 Authors: Gilbert L; He X; Farmer P; Rubin J; Drissi H; van Wijnen AJ; Lian JB; Stein GS; Nanes MS
  • Nitric oxide represses RANKL expression at a transcriptional level in stromal cells.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 16 Page(s): S490 - S490
    09/01/2001 Authors: Rubin J; Murphy T; Zhu L; Nanes MS; Fan X
  • The osteoblast differentiation factor RUNX2/Cbfa1 is suppressed by tumor necrosis factor-alpha.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 16 Page(s): S204 - S204
    09/01/2001 Authors: Gilbert LC; He X; Rubin J; Drissi H; van Wijnen AJ; Lian JB; Stein GS; Nanes MS
  • Mechanical strain increases nitric oxide production in murine stromal cell culture.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 16 Page(s): S201 - S201
    09/01/2001 Authors: Fan X; Murphy TC; Zhu L; Nanes MS; Taylor WR; Rubin J
  • Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells.
    Am J Physiol Endocrinol Metab Volume: 280 Page(s): E103 - E111
    01/01/2001 Authors: Fan X; Fan D; Gewant H; Royce CL; Nanes MS; Rubin J
  • Inhibition of Osteoblast Differentiation by Tumor Necrosis Factor-.
    Endocrinology Volume: 141 Page(s): 3956 - 3964
    11/01/2000 Authors: Gilbert L; He X; Farmer P; Boden S; Kozlowski M; Rubin J; Nanes MS
  • Inhibition of osteoblast differentiation by tumor necrosis factor-alpha.
    Endocrinology Volume: 141 Page(s): 3956 - 3964
    11/01/2000 Authors: Gilbert L; He X; Farmer P; Boden S; Kozlowski M; Rubin J; Nanes MS
  • Membrane-bound macrophage colony stimulating factor does not regulate OPGL-driven osteoclastogenesis.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 15 Page(s): S379 - S379
    09/01/2000 Authors: Fan X; Fan D; Gewant H; Royce C; Nanes MS; Rubin J
  • Inhibitory effect of NF-kappaB on 1,25-dihydroxyvitamin D(3) and retinoid X receptor function.
    Am J Physiol Endocrinol Metab Volume: 279 Page(s): E213 - E220
    07/01/2000 Authors: Farmer PK; He X; Schmitz ML; Rubin J; Nanes MS
  • Mechanical strain inhibits expression of osteoclast differentiation factor by murine stromal cells.
    Am J Physiol Cell Physiol Volume: 278 Page(s): C1126 - C1132
    06/01/2000 Authors: Rubin J; Murphy T; Nanes MS; Fan X
  • Transcriptional regulation of the expression of macrophage colony stimulating factor.
    Mol Cell Endocrinol Volume: 160 Page(s): 193 - 202
    02/25/2000 Authors: Rubin J; Fan D; Wade A; Murphy TC; Gewant H; Nanes MS; Fan X; Moerenhout M; Hofstetter W
  • Declining bone mass in men with chronic pulmonary disease: contribution of glucocorticoid treatment, body mass index, and gonadal function.
    Chest Volume: 116 Page(s): 1616 - 1624
    12/01/1999 Authors: Iqbal F; Michaelson J; Thaler L; Rubin J; Roman J; Nanes MS
  • Calcitonin, vitamin D, and calcium.
    South Med J Volume: 92 Page(s): 1128 - 1131
    11/01/1999 Authors: Nanes MS
  • Usefulness of fructosamine for monitoring outpatients with diabetes.
    Am J Med Sci Volume: 318 Page(s): 316 - 323
    11/01/1999 Authors: Austin GE; Wheaton R; Nanes MS; Rubin J; Mullins RE
  • Effect of aluminum on 1,25-dihydroxyvitamin D3-stimulated osteocalcin secretion in human osteoblast-like cells (MG-63).
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 14 Page(s): S237 - S237
    09/01/1999 Authors: Fernandez-Martin JL; Naves ML; Fernandez-Coto MT; Nanes MS; Cannata JB
  • Dexamethasone inhibits secretion of soluble-MCSF by affecting protein trafficking in bone stromal cells.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 14 Page(s): S297 - S297
    09/01/1999 Authors: Fan X; Gewant H; Murphy TC; Nanes MS; Rubin J
  • ODF/TRANCE expression is downregulated by mechanical strain in murine stromal cells.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 14 Page(s): S236 - S236
    09/01/1999 Authors: Rubin J; Murphy TC; Nanes MS; Fan X
  • Tumor necrosis factor-alpha inhibits osteoblast differentiation and expression of the skeletal differentiation factor Cbfa-1.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 14 Page(s): S195 - S195
    09/01/1999 Authors: Nanes MS; Gilbert L; Farmer P; He X; Boden SD; Rubin J
  • Role of NFkappaB in the regulation of macrophage colony stimulating factor by tumor necrosis factor-alpha in ST2 bone stromal cells.
    J Cell Physiol Volume: 179 Page(s): 193 - 200
    05/01/1999 Authors: Isaacs SD; Fan X; Fan D; Gewant H; Murphy TC; Farmer P; Taylor WR; Nanes MS; Rubin J
  • LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation.
    Endocrinology Volume: 139 Page(s): 5125 - 5134
    12/01/1998 Authors: Boden SD; Liu Y; Hair GA; Helms JA; Hu D; Racine M; Nanes MS; Titus L
  • Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1).
    Spine (Phila Pa 1976) Volume: 23 Page(s): 2486 - 2492
    12/01/1998 Authors: Boden SD; Titus L; Hair G; Liu Y; Viggeswarapu M; Nanes MS; Baranowski C
  • Collagen N-telopeptide excretion in men: the effects of age and intrasubject variability.
    J Clin Endocrinol Metab Volume: 83 Page(s): 3930 - 3935
    11/01/1998 Authors: Orwoll ES; Bell NH; Nanes MS; Flessland KA; Pettinger MB; Mallinak NJ; Cain DF
  • Tumor necrosis factor activates a nuclear inhibitor of vitamin D and retinoid-X receptors.
    Mol Cell Endocrinol Volume: 141 Page(s): 65 - 72
    06/25/1998 Authors: Fernandez-Martin JL; Kurian S; Farmer P; Nanes MS
  • Dexamethasone promotes expression of membrane-bound macrophage colony-stimulating factor in murine osteoblast-like cells.
    Endocrinology Volume: 139 Page(s): 1006 - 1012
    03/01/1998 Authors: Rubin J; Biskobing DM; Jadhav L; Fan D; Nanes MS; Perkins S; Fan X
  • Ligand independent activation of RXR and VDR by Nf kappa B.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 12 Page(s): 51 - 51
    08/01/1997 Authors: Nanes MS; Kurian S; Rubin J; Farmer P
  • Dexamethasone promotes expression of membrane bound macrophage colony stimulating factor
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 12 Page(s): T359 - T359
    08/01/1997 Authors: Rubin J; Biskobing DM; Jadhav L; Nanes MS; Perkins S; Fan X
  • Development of a reference range and determination of the intrasubject variability of NTx excretion in males.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 12 Page(s): S610 - S610
    08/01/1997 Authors: Orwoll E; Bell N; Nanes MS; Iqbal F; Flessland K; Pettinger M; Mallinak N; Cain D
  • Tumor necrosis factor stimulates expression of membrane bound macrophage colony stimulating factor
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 12 Page(s): P220 - P220
    08/01/1997 Authors: Isaacs SD; Fan X; Nanes MS; Rubin J
  • BMP-6 induces a novel LIM protein involved in bone mineralization and osteocalcin secretion
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 12 Page(s): 49 - 49
    08/01/1997 Authors: Liu Y; Hair G; Titus L; Nanes MS; Boden SD
  • Glucocorticoid-induced differentiation of fetal rat calvarial osteoblasts is mediated by bone morphogenetic protein-6.
    Endocrinology Volume: 138 Page(s): 2820 - 2828
    07/01/1997 Authors: Boden SD; Hair G; Titus L; Racine M; McCuaig K; Wozney JM; Nanes MS
  • Ca2+-receptor-mediated regulation of parathyroid and renal function
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES Volume: 312 Page(s): 99 - 109
    09/01/1996 Authors: Nanes MS
  • TNF-alpha induces an intranuclear repressor that inhibits vitamin D and retinoid X receptor function
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 11 Page(s): 80 - 80
    08/01/1996 Authors: FernandezMartin JL; Kurian S; Nanes MS
  • Differential effects and glucocorticoid potentiation of bone morphogenetic protein action during rat osteoblast differentiation in vitro.
    Endocrinology Volume: 137 Page(s): 3401 - 3407
    08/01/1996 Authors: Boden SD; McCuaig K; Hair G; Racine M; Titus L; Wozney JM; Nanes MS
  • Glucocorticoid-induced differentiation of fetal rat calvarial osteoblasts is mediated by BMP-6.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 11 Page(s): 91 - 91
    08/01/1996 Authors: Boden SD; Hair G; Racine M; McCuaig K; Wozney JM; Nanes MS
  • 1,25(OH)2D3 and cAMP synergistically induce complement 5a receptor messenger RNA.
    Am J Med Sci Volume: 311 Page(s): 73 - 79
    02/01/1996 Authors: Rubin J; Biskobing D; Titus L; Thornton DL; Catherwood BD; Nanes MS
  • Formation of osteoclast-like cells is suppressed by low frequency, low intensity electric fields.
    J Orthop Res Volume: 14 Page(s): 7 - 15
    01/01/1996 Authors: Rubin J; McLeod KJ; Titus L; Nanes MS; Catherwood BD; Rubin CT
  • EFFECTS OF BMPS ON OSTEOBLAST DIFFERENTIATION IN-VITRO
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 10 Page(s): S309 - S309
    08/01/1995 Authors: MCCUAIG K; RACINE M; NANES MS; TITUS L; CATHERWOOD BD; WOZNEY JM
  • TUMOR-NECROSIS-FACTOR-ALPHA STIMULATES RETINOID-X RECEPTOR-BINDING AND TRANSACTIVATION AT THE RETINOID-X RESPONSE ELEMENT
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 10 Page(s): S390 - S390
    08/01/1995 Authors: NANES MS; KURIAN S; BODEN S; TITUS L
  • Inhibition of 1,25-dihydroxyvitamin D3 stimulated osteocalcin gene transcription by tumor necrosis factor-alpha: structural determinants within the vitamin D response element.
    Endocrinology Volume: 134 Page(s): 2524 - 2531
    06/01/1994 Authors: Kuno H; Kurian SM; Hendy GN; White J; deLuca HF; Evans CO; Nanes MS
  • Increased expression of tissue plasminogen activator messenger ribonucleic acid is an immediate response to parathyroid hormone in neonatal rat osteoblasts.
    Endocrinology Volume: 134 Page(s): 1429 - 1436
    03/01/1994 Authors: Catherwood BD; Titus L; Evans CO; Rubin J; Boden SD; Nanes MS
  • A single up-stream element confers responsiveness to 1,25-dihydroxyvitamin D3 and tumor necrosis factor-alpha in the rat osteocalcin gene.
    Endocrinology Volume: 134 Page(s): 1113 - 1120
    03/01/1994 Authors: Nanes MS; Kuno H; Demay MB; Kurian M; Hendy GN; DeLuca HF; Titus L; Rubin J
  • 1,25-Dihydroxyvitamin D3 and phorbol myristate acetate synergistically increase carbonic anhydrase-II expression in a human myelomonocytic cell line.
    Endocrinology Volume: 134 Page(s): 1493 - 1498
    03/01/1994 Authors: Biskobing DM; Nanes MS; Rubin J
  • Rat osteoblasts and ROS 17/2.8 cells contain a similar protein tyrosine phosphatase.
    Bone Miner Volume: 23 Page(s): 267 - 284
    12/01/1993 Authors: Titus L; Marzilli LG; Rubin J; Nanes MS; Catherwood BD
  • NOVEL METHOD FOR KINETIC-ANALYSIS OF PROTEIN-TYROSINE-PHOSPHATASE ACTIVITY
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 8 Page(s): S370 - S370
    08/01/1993 Authors: TITUS L; CATHERWOOD BD; RUBIN J; NANES MS; POHL J
  • EXPRESSION OF TISSUE-PLASMINOGEN ACTIVATOR (TPA) MESSENGER-RNA IS AN IMMEDIATE RESPONSE TO PARATHYROID-HORMONE (PTH) IN NEONATAL RAT OSTEOBLASTS
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 8 Page(s): S370 - S370
    08/01/1993 Authors: CATHERWOOD BD; EVANS CO; RUBIN J; TITUS FL; BODEN SD; NANES MS
  • MINERALIZATION BY BETA-GLYCEROLPHOSPHATE ENHANCES OSTEOCALCIN PRODUCTION BY MC3T3-E1 CELLS IN ALPHA-MEM BUT NOT BGJ(B)
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 8 Page(s): S297 - S297
    08/01/1993 Authors: BODEN SD; SOYOOLA E; NANES MS; TITUS FL; RUBIN JE; CATHERWOOD BD
  • THE VITAMIN-D RESPONSE ELEMENT MEDIATES THE INHIBITORY EFFECT OF TNF-ALPHA ON OSTEOCALCIN GENE-TRANSCRIPTION
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 8 Page(s): S163 - S163
    08/01/1993 Authors: NANES MS; KUNO H; DEMAY M; TITUS L; CATHERWOOD BD; RUBIN J
  • Tumor necrosis factor alpha decreases 1,25-dihydroxyvitamin D3 receptors in osteoblastic ROS 17/2.8 cells.
    J Bone Miner Res Volume: 8 Page(s): 997 - 1003
    08/01/1993 Authors: Mayur N; Lewis S; Catherwood BD; Nanes MS
  • 1,25(OH)2D(3) IS REQUIRED FOR PROTEIN-KINASE-C UP-REGULATION OF CARBONIC ANHYDRASE-II IN A HUMAN MONOMYELOCYTIC CELL-LINE
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 8 Page(s): S165 - S165
    08/01/1993 Authors: BISKOBING DM; THORNTON D; NANES MS; RUBIN J
  • ELECTRIC-FIELD MODULATION OF OSTEOCLAST RECRUITMENT IN MARROW CULTURE
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 7 Page(s): S310 - S310
    08/01/1992 Authors: RUBIN J; TITUS L; CATHERWOOD B; NANES M; MCLEOD K
  • TUMOR-NECROSIS-FACTOR-ALPHA DECREASES OSTEOBLAST 1,25(OH)2D3-RECEPTORS BY A POSTTRANSCRIPTIONAL MECHANISM
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 7 Page(s): S203 - S203
    08/01/1992 Authors: MAYUR N; LEWIS SD; NANES MS
  • 1,25-D INDUCED TRANSCRIPTION OF C5AR MESSENGER-RNA IS NOT SUFFICIENT FOR C5AR EXPRESSION
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 7 Page(s): S164 - S164
    08/01/1992 Authors: RUBIN J; THORNTON D; TITUS L; CATHERWOOD BD; NANES MS
  • cAMP promotion of osteoclast-like cell development from mouse bone marrow cells requires a permissive action of 1,25-(OH)2D3.
    J Bone Miner Res Volume: 7 Page(s): 611 - 617
    06/01/1992 Authors: Rubin J; Titus L; Nanes MS
  • The genetics of multiple endocrine neoplasia syndromes.
    Annu Rev Med Volume: 43 Page(s): 253 - 268
    01/01/1992 Authors: Nanes MS; Catherwood BD
  • TUMOR-NECROSIS-FACTOR-ALPHA MODULATES 1,25-DIHYDROXY-VITAMIN-D3 RECEPTORS IN RAT OSTEOBLASTIC CELLS
    CLINICAL RESEARCH Volume: 39 Page(s): A836 - A836
    12/01/1991 Authors: MAYUR N; LEWIS S; NANES MS
  • Regulation of complement 5a receptor expression in U937 cells by phorbol ester.
    J Leukoc Biol Volume: 50 Page(s): 502 - 508
    11/01/1991 Authors: Rubin J; Titus L; Nanes MS
  • 1,25-dihydroxyvitamin D reduces parathyroid hormone receptor number in ROS 17/2.8 cells and prevents the glucocorticoid-induced increase in these receptors: relationship to adenylate cyclase activation.
    J Bone Miner Res Volume: 6 Page(s): 631 - 637
    06/01/1991 Authors: Titus L; Jackson E; Nanes MS; Rubin JE; Catherwood BD
  • Tumor necrosis factor-alpha inhibits 1,25-dihydroxyvitamin D3-stimulated bone Gla protein synthesis in rat osteosarcoma cells (ROS 17/2.8) by a pretranslational mechanism.
    Endocrinology Volume: 128 Page(s): 2577 - 2582
    05/01/1991 Authors: Nanes MS; Rubin J; Titus L; Hendy GN; Catherwood B
  • Prostaglandin E2 induction of monoblastic differentiation utilizes both cAMP and non-cAMP dependent signalling systems.
    Biochim Biophys Acta Volume: 1091 Page(s): 87 - 95
    01/10/1991 Authors: Rubin JE; Titus L; Nanes MS
  • REGULATION OF COMPLEMENT 5A BINDING BY PHORBOL-MYRISTATE
    CLINICAL RESEARCH Volume: 38 Page(s): A942 - A942
    12/01/1990 Authors: RUBIN J; TITUS L; NANES M
  • RAT OSTEOBLASTS AND ROS 17/2.8 CELLS CONTAIN SIMILAR PROTEIN TYROSINE PHOSPHATASES
    CLINICAL RESEARCH Volume: 38 Page(s): A924 - A924
    12/01/1990 Authors: TITUS L; RUBIN J; NANES MS; CATHERWOOD BD
  • TUMOR-NECROSIS-FACTOR-ALPHA INHIBITS BONE GLA PROTEIN-SYNTHESIS BY A PRETRANSLATIONAL MECHANISM
    CLINICAL RESEARCH Volume: 38 Page(s): A953 - A953
    12/01/1990 Authors: NANES MS; RUBIN J; TITUS L; HENDY G; CATHERWOOD BD
  • Interferon-gamma inhibits 1,25-dihydroxyvitamin D3-stimulated synthesis of bone GLA protein in rat osteosarcoma cells by a pretranslational mechanism.
    Endocrinology Volume: 127 Page(s): 588 - 594
    08/01/1990 Authors: Nanes MS; Rubin J; Titus L; Hendy GN; Catherwood BD
  • EVALUATION OF PHYSICIAN ACCEPTANCE OF FRUCTOSAMIN IN THE MANAGEMENT OF THE DIABETIC OUTPATIENT
    CLINICAL CHEMISTRY Volume: 36 Page(s): 1159 - 1159
    06/01/1990 Authors: WHEATON RN; AUSTIN GE; MULLINS RE; RUBIN JE; ZIEMER DC; ROGERS D; NANES M; MORIN LG; CATHERWOOD BD
  • Glucocorticoid and 1,25-dihydroxyvitamin D modulate the degree of adenosine 3',5'-monophosphate-dependent protein kinase isoenzyme I and II activation by parathyroid hormone in rat osteosarcoma cells.
    Endocrinology Volume: 125 Page(s): 2806 - 2811
    12/01/1989 Authors: Titus L; Rubin JE; Nanes MS; Catherwood BD
  • Plasma chromogranin-A in primary hyperparathyroidism.
    J Clin Endocrinol Metab Volume: 69 Page(s): 950 - 955
    11/01/1989 Authors: Nanes MS; O'Connor DT; Marx SJ
  • Inhibitory effects of tumor necrosis factor-alpha and interferon-gamma on deoxyribonucleic acid and collagen synthesis by rat osteosarcoma cells (ROS 17/2.8).
    Endocrinology Volume: 124 Page(s): 339 - 345
    01/01/1989 Authors: Nanes MS; McKoy WM; Marx SJ
  • Vitamin D metabolism in pregnant and pseudopregnant rats: identification of 25-hydroxycholecalciferol-1-hydroxylase in decidual tissue.
    Calcif Tissue Int Volume: 42 Page(s): 369 - 374
    06/01/1988 Authors: Nanes MS
  • Absent intestinal response to calciferols in hereditary resistance to 1,25-dihydroxyvitamin D: documentation and effective therapy with high dose intravenous calcium infusions.
    J Clin Endocrinol Metab Volume: 66 Page(s): 294 - 300
    02/01/1988 Authors: Bliziotes M; Yergey AL; Nanes MS; Muenzer J; Begley MG; Vieira NE; Kher KK; Brandi ML; Marx SJ
  • Analysis of the relation between alopecia and resistance to 1,25-dihydroxyvitamin D.
    Clin Endocrinol (Oxf) Volume: 25 Page(s): 373 - 381
    10/01/1986 Authors: Marx SJ; Bliziotes MM; Nanes M
  • EFFICACY OF SMS 201-995 IN TSH-SECRETING PITUITARY-ADENOMAS
    CLINICAL RESEARCH Volume: 34 Page(s): A714 - A714
    04/01/1986 Authors: COMI RJ; GESUNDHEIT N; NANES M; GORDEN P; WEINTRAUB BD
  • The role of decidual tissue in the development of the dependency on luteinizing hormone in the rat corpus luteum.
    Endocrinology Volume: 112 Page(s): 2181 - 2186
    06/01/1983 Authors: Nanes MS; Morishige WK; Rothchild I
  • The lack of relationship between luteinizing hormone receptors in the rat corpus luteum and the critical need for luteinizing hormone in the luteotropic process.
    Endocrinology Volume: 107 Page(s): 486 - 490
    08/01/1980 Authors: Garris DR; Nanes MS; Seguin C; Kelley PA; Rothchild I
  • Prolactin and hysterectomy delay rather than prevent the critical need for LH (LH dependency) in the luteotrophic process of the rat.
    Proc Soc Exp Biol Med Volume: 164 Page(s): 299 - 302
    07/01/1980 Authors: Nanes MS; Garris DR; Rothchild I
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