Mark Lyle
Overview
The overall goal of my research is to enhance mobility and improve quality of life for persons with locomotor impairments across the lifespan, and identify modifiable factors that will enable effective strategies to prevent injury.
Our research focus over the last 10 years has been to identify governing neural control principles that enable normal and underlie impaired task dependent lower limb control with an emphasis on clarifying the functional role of proprioceptive feedback (i.e. muscle spindles and Golgi tendon organs). Proprioceptive feedback is known to have a role in coordinating muscle activity throughout the limb, and this is achieved by muscles continuously talking to each other via proprioceptive networks. Our lab is particularly interested in determining how and to what extent proprioceptive feedback is modulated to meet unique task demands, and the extent to which the adaptive capacity to modulate proprioceptive feedback is influenced by injuries, aging and rehabilitation strategies (e.g. motor practice, targeted neuromodulation). Our efforts aim to improve the clinical management of locomotor deficits and falls in older adults, impaired mobility in patients with neurological and musculoskeletal conditions and injury prevention strategies in athletes. Relying on the fields of biomechanics, neuroscience and muscle physiology, we use technology such as 3D motion analysis, electromyography, muscle/nerve stimulation paradigms, and strength and functional assessments.
Academic Appointment
- Assistant Professor, Rehabilitation Medicine, Division of Physical Therapy, Emory University
Education
Degrees
- PhD, Biokinesiology from University of Southern California
- MS, Physical Therapy from Simmons College
- BA, Zoology from Miami University
Research
Publications
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Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context.
Sci Rep Volume: 15 Page(s): 15237
04/30/2025 Authors: Lyle MA; Wolf SL; Cuadra C -
Reducing Walking Speed Decreases Surgical Knee Loading but Not Between-Limb Symmetry in Individuals With Anterior Cruciate Ligament Reconstruction.
J Appl Biomech Page(s): 1 - 9
04/21/2025 Authors: Cottmeyer DF; Lyle MA; Sims MM; Xerogeanes JW; Tsai L-C -
Heteronymous feedback from quadriceps onto soleus in stroke survivors.
J Neuroeng Rehabil Volume: 22 Page(s): 39
02/26/2025 Authors: Cuadra C; Wolf SL; Lyle MA -
Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context.
Res Sq
11/25/2024 Authors: Lyle MA; Wolf SL; Cuadra C -
Reduced inhibition from quadriceps onto soleus after acute quadriceps fatigue suggests Golgi tendon organ contribution to heteronymous inhibition.
Eur J Neurosci Volume: 60 Page(s): 4317 - 4331
08/01/2024 Authors: Cuadra C; De Boef A; Luong S; Wolf SL; Nichols TR; Lyle MA -
Heteronymous feedback from quadriceps onto soleus in stroke survivors.
Res Sq
06/27/2024 Authors: Cuadra C; Wolf SL; Lyle MA -
Can exercise interventions reduce external knee adduction moment during gait? A systematic review and meta-analysis.
Clin Biomech (Bristol) Volume: 109 Page(s): 106064
10/01/2023 Authors: Cottmeyer DF; Hoang BH; Lyle MA; Warren GL; Tsai L-C -
Differential effect of heteronymous feedback from femoral nerve and quadriceps muscle stimulation onto soleus H-reflex.
PLoS One Volume: 18 Page(s): e0290078
01/01/2023 Authors: Cuadra C; Wolf SL; Lyle MA -
Time, graft, sex, geographic location, and isokinetic speed influence the degree of quadriceps weakness after anterior cruciate ligament reconstruction: a systematic review and meta-analysis.
Knee Surg Sports Traumatol Arthrosc Volume: 30 Page(s): 3367 - 3376
10/01/2022 Authors: Tsai L-C; Jeanfreau CM; Hamblin KA; Popovich JM; Lyle MA; Cottmeyer DF; Warren GL -
Quadriceps muscle stimulation evokes heteronymous inhibition onto soleus with limited Ia activation compared to femoral nerve stimulation.
Exp Brain Res Volume: 240 Page(s): 2375 - 2388
09/01/2022 Authors: Lyle MA; Cuadra C; Wolf SL