Murali Kaja

Department of Pediatrics
Associate Professor

(404) 727-3544
murali.kaja@emory.edu

Academic Appointment

Education

Degrees

PhD from Indian Institute of Science
MSc from University of Hyderabad
B.Sc. from Andhra University

Research

Focus

Our research focus is to understand the mechanisms by which innate and adaptive immune systems interact together in response to infection and generate the most efficient protective immune memory. Lessons learned from such experimental models will be useful for rational and refined vaccine and therapeutic design.

Publications

Regional Variation of the CD4 and CD8 T Cell Epitopes Conserved in Circulating Dengue Viruses and Shared with Potential Vaccine Candidates.
Viruses Volume: 16
05/05/2024 Authors: Chawla YM; Bajpai P; Saini K; Reddy ES; Patel AK; Murali-Krishna K; Chandele A
Severe disease during both primary and secondary dengue virus infections in pediatric populations.
Nat Med Volume: 30 Page(s): 670 - 674
03/01/2024 Authors: Aggarwal C; Ahmed H; Sharma P; Reddy ES; Nayak K; Singla M; Maheshwari D; Chawla YM; Panda H; Rai RC
Viremia and clinical manifestations in acute febrile patients of Chikungunya infection during the 2016 CHIKV outbreak in Delhi, India.
Infect Med (Beijing) Volume: 3 Page(s): 100088
03/01/2024 Authors: Sagar R; Raghavendhar S; Jain V; Khan N; Chandele A; Patel AK; Kaja M; Ray P; Kapoor N
Functional and transcriptional heterogeneity within the massively expanding HLADR+CD38+ CD8 T cell population in acute febrile dengue patients.
J Virol Volume: 97 Page(s): e0074623
11/30/2023 Authors: Singh P; Bajpai P; Maheshwari D; Chawla YM; Saini K; Reddy ES; Gottimukkala K; Nayak K; Gunisetty S; Aggarwal C
Light chain of a public SARS-CoV-2 class-3 antibody modulates neutralization against Omicron.
Cell Rep Volume: 42 Page(s): 113150
09/26/2023 Authors: Patel A; Kumar S; Lai L; Keen M; Valanparambil R; Chakravarthy C; Laughlin Z; Frank F; Cheedarla N; Verkerke HP
Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response.
Structure Volume: 31 Page(s): 801 - 811.e5
07/06/2023 Authors: Patel A; Kumar S; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Bajpai P; Raju DR; Edara VV
Prediction of human protein interactome of dengue virus non-structural protein 5 (NS5) and its downstream immunological implications.
3 Biotech Volume: 13 Page(s): 180
06/01/2023 Authors: Bhatnagar P; Bajpai P; Shrinet J; Kaja MK; Chandele A; Sitaraman R
Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response.
bioRxiv
10/24/2022 Authors: Patel A; Kumar S; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Bajpai P; Raju DR; Edara VV
Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody.
Sci Adv Volume: 8 Page(s): eadd2032
10/07/2022 Authors: Kumar S; Patel A; Lai L; Chakravarthy C; Valanparambil R; Reddy ES; Gottimukkala K; Davis-Gardner ME; Edara VV; Linderman S
Contrasting behavior between the three human monocyte subsets in dengue pathophysiology.
iScience Volume: 25 Page(s): 104384
06/17/2022 Authors: Maheshwari D; Saini K; Singh P; Singla M; Nayak K; Aggarwal C; Chawla YM; Bajpai P; Kaur M; Gunisetty S
Optimization of Flow-Cytometry Based Assay for Measuring Neutralizing Antibody Responses against Each of the Four Dengue Virus Serotypes.
Vaccines (Basel) Volume: 9
11/17/2021 Authors: Sharma P; Nayak K; Reddy ES; Farooqi H; Murali-Krishna K; Chandele A
Immunophenotyping and Transcriptional Profiling of Human Plasmablasts in Dengue.
J Virol Volume: 95 Page(s): e0061021
11/09/2021 Authors: Aggarwal C; Saini K; Reddy ES; Singla M; Nayak K; Chawla YM; Maheshwari D; Singh P; Sharma P; Bhatnagar P
Epidemiology and molecular characterization of chikungunya virus from human cases in North India, 2016.
Microbiol Immunol Volume: 65 Page(s): 290 - 301
08/01/2021 Authors: Khan N; Bhat R; Jain V; Raghavendhar B S; Patel AK; Nayak K; Chandele A; Murali-Krishna K; Ray P
Chikungunya-specific IgG and neutralizing antibody responses in natural infection of Chikungunya virus in children from India.
Arch Virol Volume: 166 Page(s): 1913 - 1920
07/01/2021 Authors: Verma A; Nayak K; Chandele A; Singla M; Ratageri VH; Lodha R; Kabra SK; Murali-Krishna K; Ray P
Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India.
Virology Volume: 558 Page(s): 13 - 21
06/01/2021 Authors: Nayak K; Gottimukkala K; Kumar S; Reddy ES; Edara VV; Kauffman R; Floyd K; Mantus G; Savargaonkar D; Goel PK
Dengue Virus Non-Structural Protein 5 as a Versatile, Multi-Functional Effector in Host-Pathogen Interactions.
Front Cell Infect Microbiol Volume: 11 Page(s): 574067
01/01/2021 Authors: Bhatnagar P; Sreekanth GP; Murali-Krishna K; Chandele A; Sitaraman R
Human immunity to chikungunya infection
Volume: 204
05/01/2020 Authors: Nayak K; Jain V; Kaur M; Khan N; Rai RC; Dixit K; Sagar R; Gupta S; Islamuddin M; Verma A
Antibody response patterns in chikungunya febrile phase predict protection versus progression to chronic arthritis.
JCI Insight Volume: 5
04/09/2020 Authors: Nayak K; Jain V; Kaur M; Khan N; Gottimukkala K; Aggarwal C; Sagar R; Gupta S; Rai RC; Dixit K
Emergence of new genotypes and lineages of dengue viruses during the 2012-15 epidemics in southern India.
Int J Infect Dis Volume: 84S Page(s): S34 - S43
07/01/2019 Authors: Ahamed SF; Rosario V; Britto C; Dias M; Nayak K; Chandele A; Kaja M-K; Shet A
Analysis of dengue specific memory B cells, neutralizing antibodies and binding antibodies in healthy adults from India.
Int J Infect Dis Volume: 84S Page(s): S57 - S63
07/01/2019 Authors: Gunisetty S; Nayak K; Chandra Rai R; Chawla Y; Reddy ES; Aggarwal C; Maheshwari D; Panda H; Ansari NA; Singh P
Immune Priming and Long-term Persistence of Memory B Cells After Inactivated Poliovirus Vaccine in Macaque Models: Support for at least 2 Doses.
Clin Infect Dis Volume: 67 Page(s): S66 - S77
10/30/2018 Authors: Bhaumik SK; Kulkarni RR; Weldon WC; Silveira ELV; Ahmed H; Gunisetty S; Chandele A; Antia R; Verma H; Sutter R
A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice.
PLoS Negl Trop Dis Volume: 12 Page(s): e0006191
01/01/2018 Authors: Ramasamy V; Arora U; Shukla R; Poddar A; Shanmugam RK; White LJ; Mattocks MM; Raut R; Perween A; Tyagi P
CpG oligonucleotide-mediated co-stimulation of mouse invariant natural killer T cells negatively regulates their activation status.
Cell Tissue Res Volume: 369 Page(s): 541 - 554
09/01/2017 Authors: Kulkarni RR; Villanueva AI; Read LR; Brisbin JT; Bhaumik SK; LaMarre J; Murali-Krishna K; Sharif S
Clinical, Serological, and Virological Analysis of 572 Chikungunya Patients From 2010 to 2013 in India.
Clin Infect Dis Volume: 65 Page(s): 133 - 140
07/01/2017 Authors: Jain J; Nayak K; Tanwar N; Gaind R; Gupta B; Shastri JS; Bhatnagar RK; Kaja MK; Chandele A; Sunil S
Enhancing the sensitivity of Dengue virus serotype detection by RT-PCR among infected children in India.
J Virol Methods Volume: 244 Page(s): 46 - 54
06/01/2017 Authors: Ahamed SF; Vivek R; Kotabagi S; Nayak K; Chandele A; Kaja M-K; Shet A
Evaluation of a pan-serotype point-of-care rapid diagnostic assay for accurate detection of acute dengue infection.
Diagn Microbiol Infect Dis Volume: 87 Page(s): 229 - 234
03/01/2017 Authors: Vivek R; Ahamed SF; Kotabagi S; Chandele A; Khanna I; Khanna N; Nayak K; Dias M; Kaja M-K; Shet A
Characterization of Human CD8 T Cell Responses in Dengue Virus-Infected Patients from India.
J Virol Volume: 90 Page(s): 11259 - 11278
12/15/2016 Authors: Chandele A; Sewatanon J; Gunisetty S; Singla M; Onlamoon N; Akondy RS; Kissick HT; Nayak K; Reddy ES; Kalam H
High yield expression and purification of Chikungunya virus E2 recombinant protein and its evaluation for serodiagnosis.
J Virol Methods Volume: 235 Page(s): 73 - 79
09/01/2016 Authors: Verma A; Chandele A; Nayak K; Kaja MK; Arulandu A; Lodha R; Ray P
A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents.
Tuberculosis (Edinb) Volume: 95 Page(s): 713 - 721
12/01/2015 Authors: Carpenter C; Sidney J; Kolla R; Nayak K; Tomiyama H; Tomiyama C; Padilla OA; Rozot V; Ahamed SF; Ponte C
Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome screening.
Tuberculosis (Edinb) Volume: 95 Page(s): 275 - 287
05/01/2015 Authors: Nayak K; Jing L; Russell RM; Davies DH; Hermanson G; Molina DM; Liang X; Sherman DR; Kwok WW; Yang J
Cellular Screens to Interrogate the Human T- and B-cell Repertoires and Design Better Vaccines
Page(s): 133 - 156
01/01/2015 Authors: Wrammert J; Murali-Krishna K
Blocking lymphocyte trafficking with FTY720 prevents inflammation-sensitized hypoxic-ischemic brain injury in newborns.
J Neurosci Volume: 34 Page(s): 16467 - 16481
12/03/2014 Authors: Yang D; Sun Y-Y; Bhaumik SK; Li Y; Baumann JM; Lin X; Zhang Y; Lin S-H; Dunn RS; Liu C-Y
Activation of the RIG-I pathway during influenza vaccination enhances the germinal center reaction, promotes T follicular helper cell induction, and provides a dose-sparing effect and protective immunity.
J Virol Volume: 88 Page(s): 13990 - 14001
12/01/2014 Authors: Kulkarni RR; Rasheed MAU; Bhaumik SK; Ranjan P; Cao W; Davis C; Marisetti K; Thomas S; Gangappa S; Sambhara S
Just-in-time vaccines: Biomineralized calcium phosphate core-immunogen shell nanoparticles induce long-lasting CD8(+) T cell responses in mice.
Nanomedicine Volume: 10 Page(s): 571 - 578
04/01/2014 Authors: Zhou W; Moguche AO; Chiu D; Murali-Krishna K; Baneyx F
NGS TRANSCRIPTIONAL PROFILING IN THE ACUTE INFECTION PHASE FOLLOWING INTRARECTAL CHALLENGE WITH SIVMAC251 IN RHESUS MACAQUES (MACACA MULATTA)
JOURNAL OF MEDICAL PRIMATOLOGY Volume: 42 Page(s): 256 - 257
10/01/2013 Authors: Palermo RE; Dzib J-FG; Agricola B; Aicher L; Thomas MJ; Green RR; Weiss J; Carter V; Agy M; Flanary L
Biomineralization and size control of stable calcium phosphate core-protein shell nanoparticles: potential for vaccine applications.
Bioconjug Chem Volume: 23 Page(s): 610 - 617
03/21/2012 Authors: Chiu D; Zhou W; Kitayaporn S; Schwartz DT; Murali-Krishna K; Kavanagh TJ; Baneyx F
Neuromagnetic evidence of impaired cortical auditory processing in pediatric intractable epilepsy.
Epilepsy Res Volume: 92 Page(s): 63 - 73
11/01/2010 Authors: Korostenskaja M; Pardos M; Fujiwara H; Kujala T; Horn P; Rose D; Byars A; Brown D; Seo JH; Wang Y
Homeostatic turnover of virus-specific memory CD8 T cells occurs stochastically and is independent of CD4 T cell help.
J Immunol Volume: 185 Page(s): 3436 - 3444
09/15/2010 Authors: Choo DK; Murali-Krishna K; Anita R; Ahmed R
Generation of Trypanosoma cruzi-specific CD8+ T-cell immunity is unaffected by the absence of type I interferon signaling.
Infect Immun Volume: 78 Page(s): 3154 - 3159
07/01/2010 Authors: Martin DL; Murali-Krishna K; Tarleton RL
IPS-1 is essential for the control of West Nile virus infection and immunity.
PLoS Pathog Volume: 6 Page(s): e1000757
02/05/2010 Authors: Suthar MS; Ma DY; Thomas S; Lund JM; Zhang N; Daffis S; Rudensky AY; Bevan MJ; Clark EA; Kaja M-K
Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo.
Immunity Volume: 31 Page(s): 110 - 121
07/17/2009 Authors: Di Paolo NC; Miao EA; Iwakura Y; Murali-Krishna K; Aderem A; Flavell RA; Papayannopoulou T; Shayakhmetov DM
Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus.
Proc Natl Acad Sci U S A Volume: 106 Page(s): 3455 - 3460
03/03/2009 Authors: Baskin CR; Bielefeldt-Ohmann H; Tumpey TM; Sabourin PJ; Long JP; Garca-Sastre A; Tolnay A-E; Albrecht R; Pyles JA; Olson PH
IFN-gamma induces the erosion of preexisting CD8 T cell memory during infection with a heterologous intracellular bacterium.
J Immunol Volume: 181 Page(s): 1700 - 1709
08/01/2008 Authors: Dudani R; Murali-Krishna K; Krishnan L; Sad S
Human effector and memory CD8+ T cell responses to smallpox and yellow fever vaccines.
Immunity Volume: 28 Page(s): 710 - 722
05/01/2008 Authors: Miller JD; van der Most RG; Akondy RS; Glidewell JT; Albott S; Masopust D; Murali-Krishna K; Mahar PL; Edupuganti S; Lalor S
Cutting edge: progesterone regulates IFN-alpha production by plasmacytoid dendritic cells.
J Immunol Volume: 180 Page(s): 2029 - 2033
02/15/2008 Authors: Hughes GC; Thomas S; Li C; Kaja M-K; Clark EA
CD8 T cell expansion and memory differentiation are facilitated by simultaneous and sustained exposure to antigenic and inflammatory milieu.
J Immunol Volume: 180 Page(s): 1131 - 1138
01/15/2008 Authors: Shaulov A; Murali-Krishna K
Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus.
J Virol Volume: 81 Page(s): 11817 - 11827
11/01/2007 Authors: Baskin CR; Bielefeldt-Ohmann H; Garca-Sastre A; Tumpey TM; Van Hoeven N; Carter VS; Thomas MJ; Proll S; Solrzano A; Billharz R
Antigen presentation by nonhemopoietic cells amplifies clonal expansion of effector CD8 T cells in a pathogen-specific manner.
J Immunol Volume: 178 Page(s): 5802 - 5811
05/01/2007 Authors: Thomas S; Kolumam GA; Murali-Krishna K
IL-12 and type-I IFN synergize for IFN-gamma production by CD4 T cells, whereas neither are required for IFN-gamma production by CD8 T cells after Listeria monocytogenes infection.
J Immunol Volume: 178 Page(s): 4498 - 4505
04/01/2007 Authors: Way SS; Havenar-Daughton C; Kolumam GA; Orgun NN; Murali-Krishna K
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought.
J Virol Volume: 81 Page(s): 2002 - 2011
02/01/2007 Authors: Masopust D; Murali-Krishna K; Ahmed R
Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation.
J Immunol Volume: 177 Page(s): 1746 - 1754
08/01/2006 Authors: Thompson LJ; Kolumam GA; Thomas S; Murali-Krishna K
T-cell tolerance or function is determined by combinatorial costimulatory signals.
EMBO J Volume: 25 Page(s): 2623 - 2633
06/07/2006 Authors: Nurieva R; Thomas S; Nguyen T; Martin-Orozco N; Wang Y; Kaja M-K; Yu X-Z; Dong C
Rapid demethylation of the IFN-gamma gene occurs in memory but not naive CD8 T cells.
J Immunol Volume: 176 Page(s): 4083 - 4093
04/01/2006 Authors: Kersh EN; Fitzpatrick DR; Murali-Krishna K; Shires J; Speck SH; Boss JM; Ahmed R
Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection.
J Immunol Volume: 176 Page(s): 3315 - 3319
03/15/2006 Authors: Havenar-Daughton C; Kolumam GA; Murali-Krishna K
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection.
J Exp Med Volume: 202 Page(s): 637 - 650
09/05/2005 Authors: Kolumam GA; Thomas S; Thompson LJ; Sprent J; Murali-Krishna K
Quantifying cell turnover using CFSE data.
J Immunol Methods Volume: 298 Page(s): 183 - 200
03/01/2005 Authors: Ganusov VV; Pilyugin SS; de Boer RJ; Murali-Krishna K; Ahmed R; Antia R
Proliferation and differentiation of CD8+ T cells in the absence of IL-2/15 receptor beta-chain expression or STAT5 activation.
J Immunol Volume: 173 Page(s): 3131 - 3139
09/01/2004 Authors: Teague RM; Tempero RM; Thomas S; Murali-Krishna K; Nelson BH
The Gads (GrpL) adaptor protein regulates T cell homeostasis.
J Immunol Volume: 173 Page(s): 1711 - 1720
08/01/2004 Authors: Yankee TM; Yun TJ; Draves KE; Ganesh K; Bevan MJ; Murali-Krishna K; Clark EA
The rescaling method for quantifying the turnover of cell populations.
J Theor Biol Volume: 225 Page(s): 275 - 283
11/21/2003 Authors: Pilyugin SS; Ganusov VV; Murali-Krishna K; Ahmed R; Antia R
Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation.
Virology Volume: 315 Page(s): 93 - 102
10/10/2003 Authors: van der Most RG; Murali-Krishna K; Lanier JG; Wherry EJ; Puglielli MT; Blattman JN; Sette A; Ahmed R
Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment.
J Virol Volume: 77 Page(s): 4911 - 4927
04/01/2003 Authors: Wherry EJ; Blattman JN; Murali-Krishna K; van der Most R; Ahmed R
Prolonged presence of effector-memory CD8 T cells in the central nervous system after dengue virus encephalitis.
Int Immunol Volume: 15 Page(s): 119 - 125
01/01/2003 Authors: van der Most RG; Murali-Krishna K; Ahmed R
Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells.
J Exp Med Volume: 195 Page(s): 1541 - 1548
06/17/2002 Authors: Becker TC; Wherry EJ; Boone D; Murali-Krishna K; Antia R; Ma A; Ahmed R
Defective generation but normal maintenance of memory T cells in old mice.
Eur J Immunol Volume: 32 Page(s): 1567 - 1573
06/01/2002 Authors: Kapasi ZF; Murali-Krishna K; McRae ML; Ahmed R
Estimating the precursor frequency of naive antigen-specific CD8 T cells.
J Exp Med Volume: 195 Page(s): 657 - 664
03/04/2002 Authors: Blattman JN; Antia R; Sourdive DJD; Wang X; Kaech SM; Murali-Krishna K; Altman JD; Ahmed R
Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha.
Adv Exp Med Biol Volume: 512 Page(s): 165 - 175
01/01/2002 Authors: Wherry EJ; Becker TC; Boone D; Kaja M-K; Ma A; Ahmed R
Recruitment times, proliferation, and apoptosis rates during the CD8(+) T-cell response to lymphocytic choriomeningitis virus.
J Virol Volume: 75 Page(s): 10663 - 10669
11/01/2001 Authors: De Boer RJ; Oprea M; Antia R; Murali-Krishna K; Ahmed R; Perelson AS
Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses.
Nat Med Volume: 7 Page(s): 206 - 214
02/01/2001 Authors: King C; Mueller Hoenger R; Malo Cleary M; Murali-Krishna K; Ahmed R; King E; Sarvetnick N
Gene expression in antigen-specific CD8+ T cells during viral infection.
J Immunol Volume: 166 Page(s): 795 - 799
01/15/2001 Authors: Grayson JM; Murali-Krishna K; Altman JD; Ahmed R
Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection.
J Immunol Volume: 165 Page(s): 6081 - 6090
12/01/2000 Authors: Blattman JN; Sourdive DJ; Murali-Krishna K; Ahmed R; Altman JD
Chimeric yellow fever/dengue virus as a candidate dengue vaccine: quantitation of the dengue virus-specific CD8 T-cell response.
J Virol Volume: 74 Page(s): 8094 - 8101
09/01/2000 Authors: van Der Most RG; Murali-Krishna K; Ahmed R; Strauss JH
Cutting edge: naive T cells masquerading as memory cells.
J Immunol Volume: 165 Page(s): 1733 - 1737
08/15/2000 Authors: Murali-Krishna K; Ahmed R
Antiviral CD4 and CD8 T-cell memory: differences in the size of the response and activation requirements.
Philos Trans R Soc Lond B Biol Sci Volume: 355 Page(s): 373 - 379
03/29/2000 Authors: Whitmire JK; Murali-Krishna K; Altman J; Ahmed R
4-1BB costimulation is required for protective anti-viral immunity after peptide vaccination.
J Immunol Volume: 164 Page(s): 2320 - 2325
03/01/2000 Authors: Tan JT; Whitmire JK; Murali-Krishna K; Ahmed R; Altman JD; Mittler RS; Sette A; Pearson TC; Larsen CP
Proliferative renewal and persistence of memory CD8 T cells in MHC class-I deficient mice
Page(s): 49 - 49
01/01/2000 Authors: Murali-Krishna K
Persistence of memory CD8 T cells in MHC class I-deficient mice.
Science Volume: 286 Page(s): 1377 - 1381
11/12/1999 Authors: Murali-Krishna K; Lau LL; Sambhara S; Lemonnier F; Altman J; Ahmed R
T-cell anergy during chronic viral infection
Page(s): 243 - 253
01/01/1999 Authors: Blattman JN; Zajac AJ; Murali-Krishna K; Sourdive DJD; Suresh M; Altman JD; Ahmed R
Viral immune evasion due to persistence of activated T cells without effector function.
J Exp Med Volume: 188 Page(s): 2205 - 2213
12/21/1998 Authors: Zajac AJ; Blattman JN; Murali-Krishna K; Sourdive DJ; Suresh M; Altman JD; Ahmed R
Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection.
J Virol Volume: 72 Page(s): 8281 - 8288
10/01/1998 Authors: Whitmire JK; Asano MS; Murali-Krishna K; Suresh M; Ahmed R
Therapeutic vaccination against chronic viral infection: the importance of cooperation between CD4+ and CD8+ T cells.
Curr Opin Immunol Volume: 10 Page(s): 444 - 449
08/01/1998 Authors: Zajac AJ; Murali-Krishna K; Blattman JN; Ahmed R
Alterations in cell surface carbohydrates on T cells from virally infected mice can distinguish effector/memory CD8+ T cells from naive cells.
J Immunol Volume: 161 Page(s): 641 - 648
07/15/1998 Authors: Galvan M; Murali-Krishna K; Ming LL; Baum L; Ahmed R
Conserved T cell receptor repertoire in primary and memory CD8 T cell responses to an acute viral infection.
J Exp Med Volume: 188 Page(s): 71 - 82
07/06/1998 Authors: Sourdive DJ; Murali-Krishna K; Altman JD; Zajac AJ; Whitmire JK; Pannetier C; Kourilsky P; Evavold B; Sette A; Ahmed R
Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.
Immunity Volume: 8 Page(s): 177 - 187
02/01/1998 Authors: Murali-Krishna K; Altman JD; Suresh M; Sourdive DJ; Zajac AJ; Miller JD; Slansky J; Ahmed R
Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice.
Virology Volume: 240 Page(s): 158 - 167
01/05/1998 Authors: van der Most RG; Murali-Krishna K; Whitton JL; Oseroff C; Alexander J; Southwood S; Sidney J; Chesnut RW; Sette A; Ahmed R
In vivo dynamics of anti-viral CD8 T cell responses to different epitopes. An evaluation of bystander activation in primary and secondary responses to viral infection.
Adv Exp Med Biol Volume: 452 Page(s): 123 - 142
01/01/1998 Authors: Murali-Krishna K; Altman JD; Suresh M; Sourdive D; Zajac A; Ahmed R
High intratumoural level of cytokines mediates efficient regression of a rat histiocytoma.
Clin Exp Immunol Volume: 110 Page(s): 127 - 131
10/01/1997 Authors: Khar A; Muralikrishna K; Varalakshmi C
Differential modulation of LAK and ADCC functions of natural killer cells from AK-5 tumor-bearing rats by IL-2, IL-12 and IFN-gamma.
Cytokines Cell Mol Ther Volume: 3 Page(s): 51 - 58
03/01/1997 Authors: Muralikrishna K; Varalakshmi C; Khar A
Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection.
J Immunol Volume: 157 Page(s): 5543 - 5554
12/15/1996 Authors: van der Most RG; Sette A; Oseroff C; Alexander J; Murali-Krishna K; Lau LL; Southwood S; Sidney J; Chesnut RW; Matloubian M
Protection of adult but not newborn mice against lethal intracerebral challenge with Japanese encephalitis virus by adoptively transferred virus-specific cytotoxic T lymphocytes: requirement for L3T4+ T cells.
J Gen Virol Volume: 77 ( Pt 4) Page(s): 705 - 714
04/01/1996 Authors: Murali-Krishna K; Ravi V; Manjunath R
Japanese encephalitis virus infection of mouse cell lines: ability to prime mice for generation of virus specific cytotoxic T lymphocytes and differences in CTL recognisable viral determinants.
Arch Virol Volume: 140 Page(s): 127 - 143
01/01/1995 Authors: Murali-Krishna K; Ravi V; Manjunath R
Recognition of nonstructural protein peptides by cytotoxic T lymphocytes raised against Japanese encephalitis virus.
Microbiol Immunol Volume: 39 Page(s): 1021 - 1024
01/01/1995 Authors: Murali-Krishna K; Ramireddy B; Ravi V; Manjunath R
Cytotoxic T lymphocytes raised against Japanese encephalitis virus: effector cell phenotype, target specificity and in vitro virus clearance.
J Gen Virol Volume: 75 ( Pt 4) Page(s): 799 - 807
04/01/1994 Authors: Murali-Krishna K; Ravi V; Manjunath R

Directory section navigation

Profile

Murali Kaja

Academic Appointment

Education

Degrees

Research

Focus

Publications