Michael Koval PhD

Department of Medicine
Professor

(404) 712-2976
mhkoval@emory.edu
Koval Lab

Emory University
Pulmonary Medicine
615 Michael St, 205 Whitehead Building

Overview

My laboratory studies the molecular machinery that regulates gap junctions (coordinating intercellular signaling) and tight junctions (promoting tissue barriers). Understanding how junctions are pathologically misregulated in lung disease enables us to define pharmacologic targets to control the severity of acute lung injury, pulmonary edema and diseases such as Cystic Fibrosis.

Academic Appointment

Professor of Medicine, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University School of Medicine
Professor of Cell Biology, Emory University School of Medicine

Education

Degrees

PhD from The Johns Hopkins University
A.B. from University of California

Research

Focus

My laboratory is defining the molecular machinery that regulates formation of gap junctions (which coordinate intercellular signaling) and tight junctions (which promote tissue barrier function). Understanding how junctions are pathologically misregulated during lung injury will help define control points that can potentially enhance lung cell communication and pulmonary barrier function.

Publications

Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop.
Int Forum Allergy Rhinol Page(s): e23582
05/01/2025 Authors: Roland LT; Damask C; Luong AU; Azar A; Ebert CS; Edwards T; Cahill KN; Cho D-Y; Corry D; Croston TL
Impact of Topical Corticosteroid Irrigations on Sinonasal Wound Healing.
Am J Rhinol Allergy Page(s): 19458924251334854
04/21/2025 Authors: Vuncannon JR; Altartoor KA; Kolousek A; Roback E; Burnham AJ; Koval M; Smith-Davidson P; Levy JM
Prostaglandin E Receptor 2 (EP2) Dysregulation in Allergic Fungal Rhinosinusitis Nasal Polyp Epithelium.
Laryngoscope Volume: 135 Suppl 1 Page(s): S1 - S8
04/01/2025 Authors: Smith-Davidson P; Altartoor K; Kabongo MM; Claussen H; Arthur RA; Johnston HR; DelGaudio JM; Wise SK; Solares CA; Barrow EM
Neurotropic Murine -Coronavirus Infection Causes Differential Expression of Connexin 47 in Oligodendrocyte Subpopulations Associated with Demyelination.
Mol Neurobiol Volume: 62 Page(s): 3428 - 3445
03/01/2025 Authors: Das S; Shaw AK; Das Sarma S; Koval M; Das Sarma J; Maulik M
Apical integrins as a switchable target to regulate the epithelial barrier.
J Cell Sci Volume: 137
12/15/2024 Authors: Peterson RJ; Reed RC; Zamecnik CR; Sallam MA; Finbloom JA; Martinez FJ; Levy JM; Moonwiriyakit A; Desai TA; Koval M
Effects of hyperglycemia on airway epithelial barrier function in WT and CF 16HBE cells.
Sci Rep Volume: 14 Page(s): 25095
10/23/2024 Authors: Vazquez Cegla AJ; Jones KT; Cui G; Cottrill KA; Koval M; McCarty NA
Nanostructure-Mediated Transport of Therapeutics through Epithelial Barriers.
Int J Mol Sci Volume: 25
06/28/2024 Authors: Hansen ME; Ibrahim Y; Desai TA; Koval M
Chronic alcohol use primes bronchial cells for altered inflammatory response and barrier dysfunction during SARS-CoV-2 infection.
Am J Physiol Lung Cell Mol Physiol Volume: 325 Page(s): L647 - L661
11/01/2023 Authors: Easley KF; Edenfield RC; Lott MEJ; Reed RC; Das Sarma J; Mehta AJ; Staitieh BS; Lipp EK; Cho IK; Johnson SK
Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function.
Nat Commun Volume: 14 Page(s): 6214
10/05/2023 Authors: Raya-Sandino A; Lozada-Soto KM; Rajagopal N; Garcia-Hernandez V; Luissint A-C; Brazil JC; Cui G; Koval M; Parkos CA; Nangia S
Ethanol-exposed lung fibroblasts cause airway epithelial barrier dysfunction.
Alcohol Clin Exp Res (Hoboken) Volume: 47 Page(s): 1839 - 1849
10/01/2023 Authors: Sueblinvong V; Fan X; Hart C; Molina S; Koval M; Guidot DM
The Effects of Endogenous Cannabinoids on the Mammalian Respiratory System: A Scoping Review of Cyclooxygenase-Dependent Pathways.
Cannabis Cannabinoid Res Volume: 8 Page(s): 434 - 444
06/01/2023 Authors: Kolousek A; Pak-Harvey E; Liu-Lam O; White M; Smith P; Henning F; Koval M; Levy JM
Pharmacology of pannexin channels.
Curr Opin Pharmacol Volume: 69 Page(s): 102359
04/01/2023 Authors: Koval M; Schug WJ; Isakson BE
MYOSIN LIGHT CHAIN KINASE DELETION WORSENS LUNG PERMEABILITY AND INCREASES MORTALITY IN PNEUMONIA-INDUCED SEPSIS.
Shock Volume: 59 Page(s): 612 - 620
04/01/2023 Authors: Chihade DB; Smith P; Swift DA; Otani S; Zhang W; Chen C-W; Jeffers LA; Liang Z; Shimazui T; Burd EM
The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia.
Am J Respir Cell Mol Biol Volume: 68 Page(s): 150 - 160
02/01/2023 Authors: Lyons JD; Mandal P; Otani S; Chihade DB; Easley KF; Swift DA; Burd EM; Liang Z; Koval M; Mocarski ES
Amount of Pannexin 1 in Smooth Muscle Cells Regulates Sympathetic Nerve-Induced Vasoconstriction.
Hypertension Volume: 80 Page(s): 416 - 425
02/01/2023 Authors: Dunaway LS; Billaud M; Macal E; Good ME; Medina CB; Lorenz U; Ravichandran K; Koval M; Isakson BE
Regulatory role of endoplasmic reticulum resident chaperone protein ERp29 in anti-murine -coronavirus host cell response.
J Biol Chem Volume: 299 Page(s): 102836
02/01/2023 Authors: Bose A; Kasle G; Jana R; Maulik M; Thomas D; Mulchandani V; Mukherjee P; Koval M; Das Sarma J
An RSV Live-Attenuated Vaccine Candidate Lacking G Protein Mucin Domains Is Attenuated, Immunogenic, and Effective in Preventing RSV in BALB/c Mice.
J Infect Dis Volume: 227 Page(s): 50 - 60
12/28/2022 Authors: Roe MK; Perez MA; Hsiao H-M; Lapp SA; Sun H-Y; Jadhao S; Young AR; Batista YS; Reed RC; Taz A
New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting.
Alcohol Volume: 103 Page(s): 1 - 7
09/01/2022 Authors: Khair S; Brenner LA; Koval M; Samuelson D; Cucinello-Regland JA; Anton P; Piano MR; Simon L; Crotty K; Sharieh F
Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict -coronaviral infection and replication.
Virology Volume: 569 Page(s): 13 - 28
04/01/2022 Authors: Sarkar L; Oko L; Gupta S; Bubak AN; Das B; Gupta P; Safiriyu AA; Singhal C; Neogi U; Bloom D
Electrophysiological Measurements of Isolated Blood Vessels.
Bio Protoc Volume: 12 Page(s): e4359
03/20/2022 Authors: Molina SA; Maier-Begandt D; Isakson BE; Koval M
A medium composition containing normal resting glucose that supports differentiation of primary human airway cells.
Sci Rep Volume: 12 Page(s): 1540
01/27/2022 Authors: Morgan R; Manfredi C; Easley KF; Watkins LD; Hunt WR; Goudy SL; Sorscher EJ; Koval M; Molina SA
Pannexin 1 as a driver of inflammation and ischemia-reperfusion injury.
Purinergic Signal Volume: 17 Page(s): 521 - 531
12/01/2021 Authors: Koval M; Cwiek A; Carr T; Good ME; Lohman AW; Isakson BE
A scalable workflow to characterize the human exposome.
Nat Commun Volume: 12 Page(s): 5575
09/22/2021 Authors: Hu X; Walker DI; Liang Y; Smith MR; Orr ML; Juran BD; Ma C; Uppal K; Koval M; Martin GS
Mechanisms of Connexin Regulating Peptides.
Int J Mol Sci Volume: 22
09/22/2021 Authors: King DR; Sedovy MW; Leng X; Xue J; Lamouille S; Koval M; Isakson BE; Johnstone SR
Mechanistic analysis and significance of sphingomyelinase-mediated decreases in transepithelial CFTR currents in nHBEs.
Physiol Rep Volume: 9 Page(s): e15023
09/01/2021 Authors: Cottrill KA; Giacalone VD; Margaroli C; Bridges RJ; Koval M; Tirouvanziam R; McCarty NA
Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR-mediated apical conductance.
Physiol Rep Volume: 9 Page(s): e14928
08/01/2021 Authors: Cottrill KA; Peterson RJ; Lewallen CF; Koval M; Bridges RJ; McCarty NA
Asymmetric distribution of dynamin-2 and -catenin relative to tight junction spikes in alveolar epithelial cells.
Tissue Barriers Volume: 9 Page(s): 1929786
07/03/2021 Authors: Lynn KS; Easley KF; Martinez FJ; Reed RC; Schlingmann B; Koval M
Inhibiting Connexin43/Zonula Occludens-1 Interactions Improves Alcoholic Lung Barrier Function in vivo
Volume: 35
05/01/2021 Authors: Jeffers L; James C; Reed R; Koval M
Oxidative Mitochondrial DNA Damage in Lung Epithelial Cells Induced by Non-Pore-Forming Action of the Pneumococcal Virulence Factor Pneumolysin
Volume: 203
05/01/2021 Authors: Maurice NM; Bedi B; Yuan Z; Koval M; Vidal JE; Hart C; Sadikot RT
Alcohol Decreases the Barrier Function of Airway Epithelial cells through the TGF beta 1 Pathway
Volume: 35
05/01/2021 Authors: Easley K; Mehta A; Staitieh B; Koval M
A venous-specific purinergic signaling cascade initiated by Pannexin 1 regulates TNF-induced increases in endothelial permeability.
Sci Signal Volume: 14
03/02/2021 Authors: Maier-Begandt D; Comstra HS; Molina SA; Krger N; Ruddiman CA; Chen Y-L; Chen X; Biwer LA; Johnstone SR; Lohman AW
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium.
J Clin Invest Volume: 131
01/04/2021 Authors: Schuler BA; Habermann AC; Plosa EJ; Taylor CJ; Jetter C; Negretti NM; Kapp ME; Benjamin JT; Gulleman P; Nichols DS
Above the Matrix: Functional Roles for Apically Localized Integrins.
Front Cell Dev Biol Volume: 9 Page(s): 699407
01/01/2021 Authors: Peterson RJ; Koval M
Integrated evaluation of lung disease in single animals.
PLoS One Volume: 16 Page(s): e0246270
01/01/2021 Authors: Mandal P; Lyons JD; Burd EM; Koval M; Mocarski ES; Coopersmith CM
Alteration of Membrane Cholesterol Content Plays a Key Role in Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Channel Activity.
Front Physiol Volume: 12 Page(s): 652513
01/01/2021 Authors: Cui G; Cottrill KA; Strickland KM; Mashburn SA; Koval M; McCarty NA
Measurement of Lung Vessel and Epithelial Permeability In Vivo with Evans Blue.
Methods Mol Biol Volume: 2367 Page(s): 137 - 148
01/01/2021 Authors: Smith P; Jeffers LA; Koval M
Nanotopography Enhances Dynamic Remodeling of Tight Junction Proteins through Cytosolic Liquid Complexes.
ACS Nano Volume: 14 Page(s): 13192 - 13202
10/27/2020 Authors: Huang X; Shi X; Hansen ME; Setiady I; Nemeth CL; Celli A; Huang B; Mauro T; Koval M; Desai TA
HYPERGLYCEMIC CONDITIONS DYSREGULATE BARRIER AND CHANNEL FUNCTION IN HUMAN CYSTIC FIBROSIS BRONCHIAL EPITHELIA
Volume: 55 Page(s): S47 - S47
10/01/2020 Authors: Cui G; Cottrill KA; Strickland K; Mashburn SA; Koval M; McCarty NA
BASOLATERAL SMASE INHIBITS THE APICAL CFTR CHANNEL IN PRIMARY BRONCHIAL EPITHELIAL CELLS
Volume: 55 Page(s): S71 - S72
10/01/2020 Authors: Cottrill KA; Koval M; Bridges RJ; McCarty NA
Ruffles and spikes: Control of tight junction morphology and permeability by claudins.
Biochim Biophys Acta Biomembr Volume: 1862 Page(s): 183339
09/01/2020 Authors: Lynn KS; Peterson RJ; Koval M
Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 infection in the lung epithelium.
bioRxiv
08/03/2020 Authors: Schuler BA; Christian Habermann A; Plosa EJ; Taylor CJ; Jetter C; Kapp ME; Benjamin JT; Gulleman P; Nichols DS; Braunstein LZ
UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis.
Clin Sci (Lond) Volume: 134 Page(s): 1911 - 1934
07/31/2020 Authors: Bedi B; Lin K-C; Maurice NM; Yuan Z; Bijli K; Koval M; Hart CM; Goldberg JB; Stecenko A; Sadikot RT
Consideration of Pannexin 1 channels in COVID-19 pathology and treatment.
Am J Physiol Lung Cell Mol Physiol Volume: 319 Page(s): L121 - L125
07/01/2020 Authors: Swayne LA; Johnstone SR; Ng CS; Sanchez-Arias JC; Good ME; Penuela S; Lohman AW; Wolpe AG; Laubach VE; Koval M
Endothelial Pannexin 1 Channels Control Inflammation by Regulating Intracellular Calcium.
J Immunol Volume: 204 Page(s): 2995 - 3007
06/01/2020 Authors: Yang Y; Delalio LJ; Best AK; Macal E; Milstein J; Donnelly I; Miller AM; McBride M; Shu X; Koval M
Detrimental effects of flame retardant, PBB153, exposure on sperm and future generations.
Sci Rep Volume: 10 Page(s): 8567
05/22/2020 Authors: Greeson KW; Fowler KL; Estave PM; Kate Thompson S; Wagner C; Clayton Edenfield R; Symosko KM; Steves AN; Marder EM; Terrell ML
Type-2 Cannabinoid Receptors Maintain Epithelial Barrier in Aspirin-Exacerbated Respiratory Disease
Volume: 145 Page(s): AB148 - AB148
02/01/2020 Authors: Levy J; Watkins L; Mashburn S; Roland L; Battle M; Molina S; Wise S; DelGaudio J; Moore B; Guidot D
STREPTOCOCCUS PNEUMONIAE-INDUCED EPITHELIAL BARRIER FUNCTION IS MEDIATED BY MITOCHONDRIAL REACTIVE OXYGEN SPECIES GENERATION AND ATTENUATED BY A MITOCHONDRIALLY-TARGETED ANTIOXIDANT
Volume: 68 Page(s): 603 - 603
02/01/2020 Authors: Maurice NM; Bedi B; Yuan Z; Koval M; Hart M; Sadikot RT
CHRONIC ALCOHOL INGESTION RENDERS MICE VULNERABLE TO HYDROSTATIC PULMONARY EDEMA
Volume: 68 Page(s): 623 - 623
02/01/2020 Authors: Jeffers LA; Nguyen T; Staitieh BS; Koval M
CHRONIC ALCOHOL INGESTION RENDERS MICE VULNERABLE TO HYDROSTATIC PULMONARY EDEMA
Volume: 68 Page(s): 601 - 601
02/01/2020 Authors: Jeffers LA; Nguyen T; Staitieh BS; Koval M
Streptococcus Pneumoniae-Induced Epithelial Barrier Dysfunction Is Mediated by Mitochondrial Reactive Oxygen Species Generation and Attenuated by a Mitochondrially-Targeted Antioxidant
Volume: 201
01/01/2020 Authors: Maurice NM; Bedi B; Yuan Z; Koval M; Hart C; Sadikot RT
Correction: Chronic Alcohol Ingestion Increases Mortality and Organ Injury in a Murine Model of Septic Peritonitis.
PLoS One Volume: 15 Page(s): e0239568
01/01/2020 Authors: Yoseph BP; Breed E; Overgaard CE; Ward CJ; Liang Z; Wagener ME; Lexcen DR; Lusczek ER; Beilman GJ; Burd EM
Increased Hydrostatic Fluid Pressure Sensitizes the Alcoholic Lung to Pulmonary Edema
Volume: 201
01/01/2020 Authors: Jeffers L; Nguyen T; Staitieh BS; Koval M
Effects of different routes of endotoxin injury on barrier function inalcoholic lung syndrome.
Alcohol Volume: 80 Page(s): 81 - 89
11/01/2019 Authors: Smith P; Jeffers LA; Koval M
MODELING COMPLEMENT-MEDIATED ACUTE LUNG INJURY IN SICKLE CELL MICE
Volume: 114 Page(s): 496 - 496
10/01/2019 Authors: Chonat S; Patel S; Jeffers L; Koval M; Archer D; Joiner C; Stowell S
Pseudomonas aeruginosa Induced Host Epithelial Cell Mitochondrial Dysfunction.
Sci Rep Volume: 9 Page(s): 11929
08/15/2019 Authors: Maurice NM; Bedi B; Yuan Z; Goldberg JB; Koval M; Hart CM; Sadikot RT
Pharmacological stimulation of G-protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells.
Int Immunopharmacol Volume: 73 Page(s): 353 - 361
08/01/2019 Authors: Moonwiriyakit A; Koval M; Muanprasat C
MYOSIN LIGHT CHAIN KINASE (MLCK) KNOCKOUT MICE PARADOXICALLY DEMONSTRATE INCREASED MORTALITY IN PSEUDOMONAS PNEUMONIA-INDUCED SEPSIS
Volume: 51 Page(s): 51 - 51
06/01/2019 Authors: Chihade DB; Smith P; Otani S; Zhang W; Chen C-W; Jeffers L; Liang Z; Burd EM; Farris AB; Koval M
Chronic Alcohol Significantly Affects Pulmonary Function Both at Baseline and in Response to Endotoxemia
Volume: 33
04/01/2019 Authors: Jeffers LA; Smith P; Chonat S; Koval M
Association of dynamin-2 with changes in alveolar epithelial tight junction morphology.
Volume: 29
12/15/2018 Authors: Lynn KS; Schlingmann B; Cornely RM; Molina SA; Koval M
Mouse hepatitis virus restricts ERp29 mediated chaperonin pathways of gap junction protein Connexin 43 trafficking and assembly.
Volume: 29
12/15/2018 Authors: Bose A; Koval M; Das Sarma J
Nanowires that interact with beta ??1 integrin increase transpeithelial permeability and induce cytoskeletal rearrangement.
Volume: 29
12/15/2018 Authors: Peterson RJ; Zamecnik CR; Desai TA; Koval M
Connexins: Synthesis, Post-Translational Modifications, and Trafficking in Health and Disease.
Int J Mol Sci Volume: 19
04/26/2018 Authors: Aasen T; Johnstone S; Vidal-Brime L; Lynn KS; Koval M
Pannexin 1 and a Venous-specific Purinergic Cascade Induces Endothelial Leak in Response to TNF alpha
Volume: 32
04/01/2018 Authors: Comstra HS; Begandt D; Molina S; Kruger N; Biwer L; Johnstone SR; Lohman A; Good ME; DeLalio LJ; Bacon H
Hyperoxia induces paracellular leak and alters claudin expression by neonatal alveolar epithelial cells.
Pediatr Pulmonol Volume: 53 Page(s): 17 - 27
01/01/2018 Authors: Vyas-Read S; Vance RJ; Wang W; Colvocoresses-Dodds J; Brown LA; Koval M
PHENOTYPE AND GLUCOSE UTILIZATION CHARACTERISTICS OF CONDITIONALLY REPROGRAMMED PRIMARY HUMAN AIRWAY EPITHELIA
PEDIATRIC PULMONOLOGY Volume: 52 Page(s): S253 - S253
09/01/2017 Authors: Molina SA; Vance RJ; McCarty NA; Koval M
Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis.
Mol Med Volume: 23 Page(s): 155 - 165
08/01/2017 Authors: Lorentz CA; Liang Z; Meng M; Chen C-W; Yoseph BP; Breed ER; Mittal R; Klingensmith NJ; Farris AB; Burd EM
Peroxisome proliferator-activated receptor- agonists attenuate biofilm formation by Pseudomonas aeruginosa.
FASEB J Volume: 31 Page(s): 3608 - 3621
08/01/2017 Authors: Bedi B; Maurice NM; Ciavatta VT; Lynn KS; Yuan Z; Molina SA; Joo M; Tyor WR; Goldberg JB; Koval M
Calibrated flux measurements reveal a nanostructure-stimulated transcytotic pathway.
Exp Cell Res Volume: 355 Page(s): 153 - 161
06/15/2017 Authors: Stewart T; Koval WT; Molina SA; Bock SM; Lillard JW; Ross RF; Desai TA; Koval M
Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.
Ann N Y Acad Sci Volume: 1397 Page(s): 119 - 129
06/01/2017 Authors: Cornely RM; Schlingmann B; Shepherd WS; Chandler JD; Neujahr DC; Koval M
Insulin signaling via the PI3-kinase/Akt pathway regulates airway glucose uptake and barrier function in a CFTR-dependent manner.
Am J Physiol Lung Cell Mol Physiol Volume: 312 Page(s): L688 - L702
05/01/2017 Authors: Molina SA; Moriarty HK; Infield DT; Imhoff BR; Vance RJ; Kim AH; Hansen JM; Hunt WR; Koval M; McCarty NA
Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion.
Shock Volume: 47 Page(s): 184 - 192
02/01/2017 Authors: Klingensmith NJ; Yoseph BP; Liang Z; Lyons JD; Burd EM; Margoles LM; Koval M; Ford ML; Coopersmith CM
Ppar gamma Agonists Attenuate Biofilm Formation By Pseudomonas AerugINOSa
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 195
01/01/2017 Authors: Bedi B; Maurice NM; Ciavatta VT; Tyor WR; Yuan Z; Goldberg JB; Hart CM; Koval MH; Sadikot RT
ACTIVATION OF AKT SIGNALING IN HUMAN AIRWAY CELLS EXPRESSING MUTANT CFTR DIFFERS COMPARED TO WILD-TYPE
PEDIATRIC PULMONOLOGY Volume: 51 Page(s): 242 - 242
10/01/2016 Authors: Molina SA; Vance RJ; Imhoff B; McCarty NA; Koval M
Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions.
Nat Commun Volume: 7 Page(s): 12276
07/25/2016 Authors: Schlingmann B; Overgaard CE; Molina SA; Lynn KS; Mitchell LA; Dorsainvil White S; Mattheyses AL; Guidot DM; Capaldo CT; Koval M
Data of the molecular dynamics simulations of mutations in the human connexin46 docking interface.
Data Brief Volume: 7 Page(s): 93 - 99
06/01/2016 Authors: Schadzek P; Schlingmann B; Schaarschmidt F; Lindner J; Koval M; Heisterkamp A; Ngezahayo A; Preller M
Claudin-5 Decreases Alveolar Barrier Function in Alcoholic Lung Syndrome by Displacing Claudin-18 from Tight Junctions
FASEB JOURNAL Volume: 30
04/01/2016 Authors: Schlingmann BL; White SD; Molina S; Lynn KS; Capaldo CT; Koval M
Alcohol Consumption Increases Claudin-18 Turnover in Alveolar Epithelial Cells
FASEB JOURNAL Volume: 30
04/01/2016 Authors: White SHD; Molina SA; Capaldo CT; Schlingmann BL; Koval MH
Functional analysis of the cataract related mutation N188T in human connexin46 (hCx46)
ACTA PHYSIOLOGICA Volume: 216
03/01/2016 Authors: Schadzek P; Schlingmann B; Schaarschmidt F; Heisterkamp A; Koval M; Preller M; Ngezahayo A
Systems Proteomics View of the Endogenous Human Claudin Protein Family.
J Proteome Res Volume: 15 Page(s): 339 - 359
02/05/2016 Authors: Liu F; Koval M; Ranganathan S; Fanayan S; Hancock WS; Lundberg EK; Beavis RC; Lane L; Duek P; McQuade L
The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels.
Biochim Biophys Acta Volume: 1858 Page(s): 57 - 66
01/01/2016 Authors: Schadzek P; Schlingmann B; Schaarschmidt F; Lindner J; Koval M; Heisterkamp A; Preller M; Ngezahayo A
INSULIN IMPAIRS AIRWAY BARRIER FUNCTION IN CYSTIC FIBROSIS RELATED DIABETES
PEDIATRIC PULMONOLOGY Volume: 50 Page(s): 246 - 246
10/01/2015 Authors: Molina SA; Moriarty HK; Kim AH; McCarty NA; Koval M
Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss.
J Clin Invest Volume: 125 Page(s): 3519 - 3531
09/01/2015 Authors: He P; Zhao L; Zhu L; Weinman EJ; De Giorgio R; Koval M; Srinivasan S; Yun CC
Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.
Am J Physiol Lung Cell Mol Physiol Volume: 309 Page(s): L475 - L487
09/01/2015 Authors: Molina SA; Stauffer B; Moriarty HK; Kim AH; McCarty NA; Koval M
HNF4 regulates claudin-7 protein expression during intestinal epithelial differentiation.
Am J Pathol Volume: 185 Page(s): 2206 - 2218
08/01/2015 Authors: Farkas AE; Hilgarth RS; Capaldo CT; Gerner-Smidt C; Powell DR; Vertino PM; Koval M; Parkos CA; Nusrat A
The relative balance of GM-CSF and TGF-1 regulates lung epithelial barrier function.
Am J Physiol Lung Cell Mol Physiol Volume: 308 Page(s): L1212 - L1223
06/15/2015 Authors: Overgaard CE; Schlingmann B; Dorsainvil White S; Ward C; Fan X; Swarnakar S; Brown LAS; Guidot DM; Koval M
The expanding diversity of roles for claudins.
Semin Cell Dev Biol Volume: 42 Page(s): 1 - 2
06/01/2015 Authors: Koval M
Claudins: Gatekeepers of lung epithelial function.
Semin Cell Dev Biol Volume: 42 Page(s): 47 - 57
06/01/2015 Authors: Schlingmann B; Molina SA; Koval M
Nanotopography facilitates in vivo transdermal delivery of high molecular weight therapeutics through an integrin-dependent mechanism.
Nano Lett Volume: 15 Page(s): 2434 - 2441
04/08/2015 Authors: Walsh L; Ryu J; Bock S; Koval M; Mauro T; Ross R; Desai T
Degradation of gap junction connexins is regulated by the interaction with Cx43-interacting protein of 75 kDa (CIP75).
Biochem J Volume: 466 Page(s): 571 - 585
03/15/2015 Authors: Kopanic JL; Schlingmann B; Koval M; Lau AF; Sorgen PL; Su VF
Alveolar barrier function in alcoholic lung syndrome is impaired by tight junction destabilization.
Ann Am Thorac Soc Volume: 12 Suppl 1 Page(s): S75 - S76
03/01/2015 Authors: Schlingmann BL; Ward C; Molina SA; Overgaard CE; Guidot DM; Koval M
Junctional adhesion molecule A promotes epithelial tight junction assembly to augment lung barrier function.
Am J Pathol Volume: 185 Page(s): 372 - 386
02/01/2015 Authors: Mitchell LA; Ward C; Kwon M; Mitchell PO; Quintero DA; Nusrat A; Parkos CA; Koval M
NF-B inhibitors impair lung epithelial tight junctions in the absence of inflammation.
Tissue Barriers Volume: 3 Page(s): e982424
01/01/2015 Authors: Ward C; Schlingmann B; Stecenko AA; Guidot DM; Koval M
Alpha-type Cx43 function is restored with 4-PBA treatment in Cystic Fibrosis airway epithelial cells that express misfolded F508del-CFTR protein
MOLECULAR BIOLOGY OF THE CELL Volume: 26
01/01/2015 Authors: Molina SA; McCarty NA; Koval M
The cataract related mutation N188T in connexin46 (Cx46) inhibits formation of functional gap junction channels by impairing docking process of Cx46 hemichannels
MOLECULAR BIOLOGY OF THE CELL Volume: 26
01/01/2015 Authors: Schadzek P; Schlingmann B; Schaarschmidt F; Heisterkamp A; Koval M; Preller M; Ngezahayo A
Proinflammatory cytokine-induced tight junction remodeling through dynamic self-assembly of claudins.
Mol Biol Cell Volume: 25 Page(s): 2710 - 2719
09/15/2014 Authors: Capaldo CT; Farkas AE; Hilgarth RS; Krug SM; Wolf MF; Benedik JK; Fromm M; Koval M; Parkos C; Nusrat A
EXPRESSION PROFILING REVEALS THAT NULI AND CUFI AIRWAY EPITHELIAL CELL MATURATION REQUIRES EXTENDED TIME IN CULTURE
PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 271 - 271
09/01/2014 Authors: Molina SA; Stauffer B; Hansen J; McCarty NA; Koval M
EXPRESSION OF Delta F508-CFTR BY AIRWAY EPITHELIAL CELLS SENSITIZES TIGHT JUNCTIONS TO GLUCOSE-INDUCED STRESS
PEDIATRIC PULMONOLOGY Volume: 49 Page(s): 263 - 263
09/01/2014 Authors: Schlingmann B; Molina SA; Hansen JM; Ziady AG; McCarty NA; Koval M
Mix and match: investigating heteromeric and heterotypic gap junction channels in model systems and native tissues.
FEBS Lett Volume: 588 Page(s): 1193 - 1204
04/17/2014 Authors: Koval M; Molina SA; Burt JM
Connexins, pannexins and innexins: protein cousins with overlapping functions.
FEBS Lett Volume: 588 Page(s): 1185
04/17/2014 Authors: Koval M; Isakson BE; Gourdie RG
Nanotopographic cues increase epithelial paracellular permeability through cytoskeletal reorganization
FASEB JOURNAL Volume: 28
04/01/2014 Authors: Hutto T; Ollerenshaw J; Swarnakar S; Bock S; Ross R; Lillard J; Koval M
Claudin-5 increases alveolar permeability in alcoholic lung syndrome by destabilizing claudin-18/zonula occludens-1 interactions
FASEB JOURNAL Volume: 28
04/01/2014 Authors: Schlingmann B; Ward C; Molina S; Overgaard C; Guidot D; Koval M
Cross-talk between Connexin 43 and CFTR in ER quality control
FASEB JOURNAL Volume: 28
04/01/2014 Authors: Molina S; McCarty N; Koval M
ERp29 mediated cross-talk between Connexin43 and CFTR in ER quality control
ACTA PHYSIOLOGICA Volume: 210 Page(s): 80 - 80
03/01/2014 Authors: Molina S; McCarty N; Koval M
Claudin-5 destabilizes claudin-18/zonula occludens-1 interactions in alveolar epithelial cells and decreases alveolar barrier function during alcoholic lung syndrome
ACTA PHYSIOLOGICA Volume: 210 Page(s): 58 - 60
03/01/2014 Authors: Schlingmann B; Ward C; Molina S; Overgaard C; Guidot D; Koval M
Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes.
Am J Physiol Lung Cell Mol Physiol Volume: 306 Page(s): L43 - L49
01/01/2014 Authors: Hunt WR; Zughaier SM; Guentert DE; Shenep MA; Koval M; McCarty NA; Hansen JM
Desmosome assembly and disassembly are membrane raft-dependent.
PLoS One Volume: 9 Page(s): e87809
01/01/2014 Authors: Stahley SN; Saito M; Faundez V; Koval M; Mattheyses AL; Kowalczyk AP
Alcohol and the Alveolar Epithelium
ALCOHOL USE DISORDERS AND THE LUNG: A CLINICAL AND PATHOPHYSIOLOGICAL APPROACH Volume: 14 Page(s): 83 - 101
01/01/2014 Authors: Molina SA; Koval M
EXTRACELLULAR PULMONARY REDOX IMBALANCE IN A MURINE MODEL OF CYSTIC FIBROSIS RELATED DIABETES
PEDIATRIC PULMONOLOGY Volume: 48 Page(s): 418 - 419
10/01/2013 Authors: Hunt WR; Zughaier SM; Guentert DE; Koval M; McCarty NA; Hansen JM
MISFOLDED CFTR INTERFERES WITH QUALITY CONTROL OF A CONNEXIN-FAMILY GAP JUNCTION PROTEIN
PEDIATRIC PULMONOLOGY Volume: 48 Page(s): 244 - 244
10/01/2013 Authors: Koval M; Molina SA; McCarty NA
Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.
Am J Physiol Lung Cell Mol Physiol Volume: 305 Page(s): L267 - L277
08/01/2013 Authors: Fan X; Staitieh BS; Jensen JS; Mould KJ; Greenberg JA; Joshi PC; Koval M; Guidot DM
Differential pathways of claudin oligomerization and integration into tight junctions.
Tissue Barriers Volume: 1 Page(s): e24518
07/01/2013 Authors: Koval M
Drowning out communication. Focus on "The human Cx26-D50A and Cx26-A88V mutations causing keratitis-ichthyosis-deafness syndrome display increased hemichannel activity".
Am J Physiol Cell Physiol Volume: 304 Page(s): C1129 - C1130
06/15/2013 Authors: Koval M
Zinc supplementation increases expression of transcription factors PU.1, KLF4, and Nrf2 in the lungs of alcohol-fed rats
FASEB JOURNAL Volume: 27
04/01/2013 Authors: Joshi PC; Fan X; Koval M; Guidot DM
Nanostructure-mediated transport of biologics across epithelial tissue: enhancing permeability via nanotopography.
Nano Lett Volume: 13 Page(s): 164 - 171
01/09/2013 Authors: Kam KR; Walsh LA; Bock SM; Koval M; Fischer KE; Ross RF; Desai TA
Hyperoxia Alters Barrier Integrity And Junctional Proteins In Neonatal Alveolar Epithelial Cells
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 187
01/01/2013 Authors: Vyas-Read S; Dodds JC; Kato S; Fifadara N; Gauthier TW; Koval M; Brown L
Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis.
PLoS One Volume: 8 Page(s): e62792
01/01/2013 Authors: Yoseph BP; Breed E; Overgaard CE; Ward CJ; Liang Z; Wagener ME; Lexcen DR; Lusczek ER; Beilman GJ; Burd EM
Claudin heterogeneity and control of lung tight junctions.
Annu Rev Physiol Volume: 75 Page(s): 551 - 567
01/01/2013 Authors: Koval M
Claudin-7 in Colonic Intestinal Epithelial Cell Differentiation and IBD
INFLAMMATORY BOWEL DISEASES Volume: 18 Page(s): S97 - S98
12/01/2012 Authors: Farkas A; Hilgarth R; Capaldo C; Parkos C; Koval M; Nusrat A
EXPRESSION OF DELTA-F508-CFTR LEADS TO DISRUPTION OF THE AIRWAY GLUCOSE BARRIER IN CF-RELATED DIABETES
PEDIATRIC PULMONOLOGY Volume: 47 Page(s): 267 - 267
09/01/2012 Authors: McCarty NA; Hansen JM; Koval MH
MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation.
Circ Res Volume: 111 Page(s): 201 - 211
07/06/2012 Authors: Johnstone SR; Kroncke BM; Straub AC; Best AK; Dunn CA; Mitchell LA; Peskova Y; Nakamoto RK; Koval M; Lo CW
Roles for claudins in alveolar epithelial barrier function.
Ann N Y Acad Sci Volume: 1257 Page(s): 167 - 174
06/01/2012 Authors: Overgaard CE; Mitchell LA; Koval M
Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization.
J Membr Biol Volume: 245 Page(s): 221 - 230
06/01/2012 Authors: Smith TD; Mohankumar A; Minogue PJ; Beyer EC; Berthoud VM; Koval M
Membrane raft microdomains are platforms for desmosome regulation
JOURNAL OF INVESTIGATIVE DERMATOLOGY Volume: 132 Page(s): S33 - S33
05/01/2012 Authors: Stahley SN; Saito M; Faundez V; Koval M; Kowalczyk AP
Increased claudin-5 increases lung epithelial permeability and is associated with disruption of tight junction assembly
FASEB JOURNAL Volume: 26
04/01/2012 Authors: Overgaard C; Mitchell LA; Ward C; Guidot DM; Koval M
Nadph oxidase regulates alveolar epithelial sodium channel (ENaC) activity and lung fluid balance in vivo via O-2-signaling.
FASEB JOURNAL Volume: 26
04/01/2012 Authors: Helms MN; Goodson P; Jain L; Koval M
Nadph oxidase regulates alveolar epithelial sodium channel activity and lung fluid balance in vivo via O signaling.
Am J Physiol Lung Cell Mol Physiol Volume: 302 Page(s): L410 - L419
02/15/2012 Authors: Goodson P; Kumar A; Jain L; Kundu K; Murthy N; Koval M; Helms MN
Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.
Alcohol Clin Exp Res Volume: 35 Page(s): 1866 - 1875
10/01/2011 Authors: Fan X; Joshi PC; Koval M; Guidot DM
Claudins: control of barrier function and regulation in response to oxidant stress.
Antioxid Redox Signal Volume: 15 Page(s): 1179 - 1193
09/01/2011 Authors: Overgaard CE; Daugherty BL; Mitchell LA; Koval M
Differential effects of claudin-3 and claudin-4 on alveolar epithelial barrier function.
Am J Physiol Lung Cell Mol Physiol Volume: 301 Page(s): L40 - L49
07/01/2011 Authors: Mitchell LA; Overgaard CE; Ward C; Margulies SS; Koval M
GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR AND TRANSFORMING GROWTH FACTOR beta HAVE OPPOSING EFFECTS ON LUNG EPITHELIAL BARRIER FUNCTION
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 35 Page(s): 177A - 177A
06/01/2011 Authors: Overgaard CE; Ward C; Guidot DM; Koval M
CHRONIC ALCOHOL INGESTION AND/OR HIV-1 TRANSGENE EXPRESSION DECREASES NRF2 EXPRESSION IN ALVEOLAR EPITHELIAL CELLS
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 35 Page(s): 178A - 178A
06/01/2011 Authors: Fan X; Joshi PC; Raynor R; Mills ST; Koval M; Guidot DM
Spontaneous lung dysfunction and fibrosis in mice lacking connexin 40 and endothelial cell connexin 43.
Am J Pathol Volume: 178 Page(s): 2536 - 2546
06/01/2011 Authors: Koval M; Billaud M; Straub AC; Johnstone SR; Zarbock A; Duling BR; Isakson BE
Activation Of The NRF2/ARE Pathway Protects Against Oxidative Stress And Alveolar Epithelial Barrier Dysfunction In HIV-1 Transgenic Rats
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 183
01/01/2011 Authors: Fan X; Joshi PC; Koval M; Guidot DM
Biochemical analysis of claudin-binding compatibility.
Volume: 762 Page(s): 13 - 26
01/01/2011 Authors: Ward C; Koval M
Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75.
J Biol Chem Volume: 285 Page(s): 40979 - 40990
12/24/2010 Authors: Su V; Nakagawa R; Koval M; Lau AF
Keratinocyte growth factor improves alveolar barrier function: keeping claudins in line.
Am J Physiol Lung Cell Mol Physiol Volume: 299 Page(s): L721 - L723
12/01/2010 Authors: Koval M
Specificity of interaction between clostridium perfringens enterotoxin and claudin-family tight junction proteins.
Toxins (Basel) Volume: 2 Page(s): 1595 - 1611
07/01/2010 Authors: Mitchell LA; Koval M
HIV-1-related proteins decrease Nrf2 expression and alter tight junction protein localization in the plasma membranes of cultured alveolar epithelial cells
FASEB JOURNAL Volume: 24
04/01/2010 Authors: Fan X; Joshi P; Koval M; Guidot DM
Mitochondrial thioredoxin-2 blocks pro-inflammatory signaling by plasma cysteine redox potential
MITOCHONDRION Volume: 10 Page(s): 241 - 241
03/01/2010 Authors: Go Y-M; Koval M; Reed M; Liang Y; Smith D; Pohl J; Jones DP
Extracellular matrix influences alveolar epithelial claudin expression and barrier function.
Am J Respir Cell Mol Biol Volume: 42 Page(s): 172 - 180
02/01/2010 Authors: Koval M; Ward C; Findley MK; Roser-Page S; Helms MN; Roman J
A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential.
Free Radic Biol Med Volume: 48 Page(s): 275 - 283
01/15/2010 Authors: Go Y-M; Park H; Koval M; Orr M; Reed M; Liang Y; Smith D; Pohl J; Jones DP
Control of lung epithelial growth by a nicotinic acetylcholine receptor: the other side of the coin.
Am J Pathol Volume: 175 Page(s): 1799 - 1801
11/01/2009 Authors: Roman J; Koval M
Tight junctions, but not too tight: fine control of lung permeability by claudins.
Am J Physiol Lung Cell Mol Physiol Volume: 297 Page(s): L217 - L218
08/01/2009 Authors: Koval M
ERp29 restricts Connexin43 oligomerization in the endoplasmic reticulum.
Mol Biol Cell Volume: 20 Page(s): 2593 - 2604
05/01/2009 Authors: Das S; Smith TD; Sarma JD; Ritzenthaler JD; Maza J; Kaplan BE; Cunningham LA; Suaud L; Hubbard MJ; Rubenstein RC
Mice lacking Junctional Adhesion Molecule-A (JAM-A) develop severe acute lung injury in response to endotoxin
FASEB JOURNAL Volume: 23
04/01/2009 Authors: Koval M; Kwon M; Torres-Gonzalez E; Peatman E; Nusrat A; Parkos CA; Rojas M
4-Phenyl butyrate (4-PBA) alters ERp29 expression, connexin localization and enhances mesenteric artery agonist-induced constriction
FASEB JOURNAL Volume: 23
04/01/2009 Authors: Looft-Wilson RC; Smith T; Koval M; Isakson BE
Regulation and roles for claudin-family tight junction proteins.
IUBMB Life Volume: 61 Page(s): 431 - 437
04/01/2009 Authors: Findley MK; Koval M
HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction.
AIDS Res Ther Volume: 6 Page(s): 1
02/04/2009 Authors: Lassiter C; Fan X; Joshi PC; Jacob BA; Sutliff RL; Jones DP; Koval M; Guidot DM
Cross-talk between pulmonary injury, oxidant stress, and gap junctional communication.
Antioxid Redox Signal Volume: 11 Page(s): 355 - 367
02/01/2009 Authors: Johnson LN; Koval M
The contribution of epithelial sodium channels to alveolar function in health and disease.
Annu Rev Physiol Volume: 71 Page(s): 403 - 423
01/01/2009 Authors: Eaton DC; Helms MN; Koval M; Bao HF; Jain L
Mice Lacking Junctional Adhesion Molecule A (JAM-A) Develop Severe Acute Lung Injury in Response to Endotoxin.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Volume: 179
01/01/2009 Authors: Kwon M; Torres E; Peatman E; Nusrat A; Parkos CA; Rojas M; Koval M
Alcohol augments the impairment of tight junction protein expression and increases permeability in the lung eipthelium of HIV-1 transgenic rats
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 32 Page(s): 224A - 224A
06/01/2008 Authors: Fan X; Lassiter C; Joshi PC; Koval M; Guidot DM
Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism.
J Virol Volume: 82 Page(s): 5519 - 5526
06/01/2008 Authors: Das Sarma J; Iacono K; Gard L; Marek R; Kenyon LC; Koval M; Weiss SR
Identification of rab20 as a potential regulator of connexin 43 trafficking.
Cell Commun Adhes Volume: 15 Page(s): 65 - 74
05/01/2008 Authors: Das Sarma J; Kaplan BE; Willemsen D; Koval M
A key claudin extracellular loop domain is critical for epithelial barrier integrity.
Am J Pathol Volume: 172 Page(s): 905 - 915
04/01/2008 Authors: Mrsny RJ; Brown GT; Gerner-Smidt K; Buret AG; Meddings JB; Quan C; Koval M; Nusrat A
Claudin-5 decreases alveolar epithelial barrier function
FASEB JOURNAL Volume: 22
04/01/2008 Authors: Findley MK; Ward C; Smith T; Guidot DM; Margulies SS; Koval MH
HIV-1 transgenic expression in rats alters tight junction protein expression and increases permeability in the lung epithelium
FASEB JOURNAL Volume: 22
04/01/2008 Authors: Fan X; Lassiter C; Joshi PC; Koval M; Guidot DM
RhoA activation and actin reorganization involved in endothelial CAM-mediated endocytosis of anti-PECAM carriers: critical role for tyrosine 686 in the cytoplasmic tail of PECAM-1.
Blood Volume: 111 Page(s): 3024 - 3033
03/15/2008 Authors: Garnacho C; Shuvaev V; Thomas A; McKenna L; Sun J; Koval M; Albelda S; Muzykantov V; Muro S
JAM-A regulates permeability and inflammation in the intestine in vivo.
J Exp Med Volume: 204 Page(s): 3067 - 3076
12/24/2007 Authors: Laukoetter MG; Nava P; Lee WY; Severson EA; Capaldo CT; Babbin BA; Williams IR; Koval M; Peatman E; Campbell JA
Regulation of heterotypic claudin compatibility.
J Biol Chem Volume: 282 Page(s): 30005 - 30013
10/12/2007 Authors: Daugherty BL; Ward C; Smith T; Ritzenthaler JD; Koval M
Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats.
Alcohol Volume: 41 Page(s): 371 - 379
08/01/2007 Authors: Fernandez AL; Koval M; Fan X; Guidot DM
Epithelial barrier dysfunction in the alcoholic lung: Basic mechanisms and potential therapies
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 31 Page(s): 290A - 290A
06/01/2007 Authors: Guider DM; Joshi PC; Koval MH; Eaton DC; Brown LS
Alterations in alveolar epithelial tight junctions induced by chronic alcohol ingestion
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 31 Page(s): 94A - 94A
06/01/2007 Authors: Johnson LN; Fernandez AL; Joshi PC; Guidot DM; Koval M
Alcohol-induced oxidant stress alters occludin expression and myosin light chain phosphorylation in the lung epithelium
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Volume: 31 Page(s): 94A - 94A
06/01/2007 Authors: Fan X; Raynor R; Mills ST; Koval M; Guidot DM
Endothelial gap junction proteins show type-specific differences in oligornerization
FASEB JOURNAL Volume: 21 Page(s): A911 - A911
04/01/2007 Authors: Koval M; Smith T; Mohankumar A; Minogue PJ; Berthoud VM; Beyer EC
Roles for both extracellular loop domains in regulating heterotypic claudin compatibility
FASEB JOURNAL Volume: 21 Page(s): A190 - A190
04/01/2007 Authors: Koval M; Daugherty BL; Smith T; Ward C; Ritzenthaler JD
Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells.
J Neurosci Volume: 26 Page(s): 6124 - 6130
06/07/2006 Authors: Blanchard-Fillion B; Prou D; Polydoro M; Spielberg D; Tsika E; Wang Z; Hazen SL; Koval M; Przedborski S; Ischiropoulos H
Control of intracellular trafficking of ICAM-1-targeted nanocarriers by endothelial Na+/H+ exchanger proteins.
Am J Physiol Lung Cell Mol Physiol Volume: 290 Page(s): L809 - L817
05/01/2006 Authors: Muro S; Mateescu M; Gajewski C; Robinson M; Muzykantov VR; Koval M
Alterations in alveolar epithelial tight junctions induced by chronic ethanol ingestion
FASEB JOURNAL Volume: 20 Page(s): A751 - A751
03/06/2006 Authors: Koval M; Fernandez AL; Joshi PC; Guidot DM
Pathways and control of connexin oligomerization.
Trends Cell Biol Volume: 16 Page(s): 159 - 166
03/01/2006 Authors: Koval M
Effect of chronic ethanol ingestion by rats on lung tight junction proteins.
JOURNAL OF INVESTIGATIVE MEDICINE Volume: 54 Page(s): S310 - S310
01/01/2006 Authors: Fernandez AL; Koval MH; Joshi PC; Werner KP; Guidot DM
Claudins--key pieces in the tight junction puzzle.
Cell Commun Adhes Volume: 13 Page(s): 127 - 138
01/01/2006 Authors: Koval M
Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants.
J Membr Biol Volume: 207 Page(s): 45 - 53
09/01/2005 Authors: Laing JG; Koval M; Steinberg TH
Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation.
Am J Physiol Lung Cell Mol Physiol Volume: 289 Page(s): L489 - L496
09/01/2005 Authors: Patel AS; Reigada D; Mitchell CH; Bates SR; Margulies SS; Koval M
Autologous apoptotic cell engulfment stimulates chemokine secretion by vascular smooth muscle cells.
Am J Pathol Volume: 167 Page(s): 345 - 353
08/01/2005 Authors: Fries DM; Lightfoot R; Koval M; Ischiropoulos H
Defining a minimal motif required to prevent connexin oligomerization in the endoplasmic reticulum.
J Biol Chem Volume: 280 Page(s): 21115 - 21121
06/03/2005 Authors: Maza J; Das Sarma J; Koval M
tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre.
J Cell Sci Volume: 118 Page(s): 2279 - 2293
05/15/2005 Authors: Yoshino A; Setty SRG; Poynton C; Whiteman EL; Saint-Pol A; Burd CG; Johannes L; Holzbaur EL; Koval M; McCaffery JM
Regulation of anti-ICAM-1 nanocarrier endocytosis and sorting by endothelial cell Na+/H+ exchanger proteins
FASEB JOURNAL Volume: 19 Page(s): A733 - A733
03/04/2005 Authors: Muro S; Mateescu M; Muzykantov V; Koval M
Interface regions of the third transmembrane domain regulate connexin oligomerization
FASEB JOURNAL Volume: 19 Page(s): A834 - A834
03/04/2005 Authors: Maza J; Das Sarma J; Koval M
ICAM-1 recycling in endothelial cells: a novel pathway for sustained intracellular delivery and prolonged effects of drugs.
Blood Volume: 105 Page(s): 650 - 658
01/15/2005 Authors: Muro S; Gajewski C; Koval M; Muzykantov VR
Regulation of connexin43 oligomerization is saturable.
Cell Commun Adhes Volume: 12 Page(s): 237 - 247
01/01/2005 Authors: Das Sarma J; Das S; Koval M
Developmental regulation of claudin localization by fetal alveolar epithelial cells.
Am J Physiol Lung Cell Mol Physiol Volume: 287 Page(s): L1266 - L1273
12/01/2004 Authors: Daugherty BL; Mateescu M; Patel AS; Wade K; Kimura S; Gonzales LW; Guttentag S; Ballard PL; Koval M
Control of claudin intercellular binding compatibility by extracellular loop domains
MOLECULAR BIOLOGY OF THE CELL Volume: 15 Page(s): 67A - 67A
11/01/2004 Authors: Daugherty BL; Koval M
Defining a minimal motif required to prevent oligomerization of connexin43 in the endoplasmic reticulum
MOLECULAR BIOLOGY OF THE CELL Volume: 15 Page(s): 308A - 308A
11/01/2004 Authors: Maza J; Das Sarma J; Koval M
Cell-cell interactions in regulating lung function.
Am J Physiol Lung Cell Mol Physiol Volume: 287 Page(s): L455 - L459
09/01/2004 Authors: Boitano S; Safdar Z; Welsh DG; Bhattacharya J; Koval M
Endothelial endocytic pathways: gates for vascular drug delivery.
Curr Vasc Pharmacol Volume: 2 Page(s): 281 - 299
07/01/2004 Authors: Muro S; Koval M; Muzykantov V
Regulation of alveolar epithelial tight junctions through differential claudin trafficking
FASEB JOURNAL Volume: 18 Page(s): A1051 - A1051
03/24/2004 Authors: Daugherty BL; Patel AS; Gonzales LW; Ballard PL; Koval M
Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells.
J Cell Sci Volume: 117 Page(s): 881 - 887
02/29/2004 Authors: Lin GC; Rurangirwa JK; Koval M; Steinberg TH
Slow intracellular trafficking of catalase nanoparticles targeted to ICAM-1 protects endothelial cells from oxidative stress.
Am J Physiol Cell Physiol Volume: 285 Page(s): C1339 - C1347
11/01/2003 Authors: Muro S; Cui X; Gajewski C; Murciano J-C; Muzykantov VR; Koval M
Heterogeneity of claudin expression by alveolar epithelial cells.
Am J Respir Cell Mol Biol Volume: 29 Page(s): 62 - 70
07/01/2003 Authors: Wang F; Daugherty B; Keise LL; Wei Z; Foley JP; Savani RC; Koval M
A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1.
J Cell Sci Volume: 116 Page(s): 1599 - 1609
04/15/2003 Authors: Muro S; Wiewrodt R; Thomas A; Koniaris L; Albelda SM; Muzykantov VR; Koval M
Developmental regulation of claudin expression by alveolar epithelial cells
FASEB JOURNAL Volume: 17 Page(s): A831 - A831
03/17/2003 Authors: Keise LL; Patel AS; Gonzales LW; Ballard PL; Koval M
Differential oligomerization of endoplasmic reticulum-retained connexin43/connexin32 chimeras.
Cell Commun Adhes Volume: 10 Page(s): 319 - 322
01/01/2003 Authors: Maza J; Mateescu M; Das Sarma J; Koval M
Trafficking of connexin45 carboxyl terminal truncation mutants in transfected ROS cells
MOLECULAR BIOLOGY OF THE CELL Volume: 13 Page(s): 353A - 353A
11/01/2002 Authors: Laing JG; Koval M; Steinberg TH
Sharing signals: connecting lung epithelial cells with gap junction channels.
Am J Physiol Lung Cell Mol Physiol Volume: 283 Page(s): L875 - L893
11/01/2002 Authors: Koval M
Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system.
J Neurovirol Volume: 8 Page(s): 381 - 391
10/01/2002 Authors: Das Sarma J; Scheen E; Seo S-H; Koval M; Weiss SR
Identification of LBM180, a lamellar body limiting membrane protein of alveolar type II cells, as the ABC transporter protein ABCA3.
J Biol Chem Volume: 277 Page(s): 22147 - 22155
06/21/2002 Authors: Mulugeta S; Gray JM; Notarfrancesco KL; Gonzales LW; Koval M; Feinstein SI; Ballard PL; Fisher AB; Shuman H
Targeted gap junction protein constructs reveal connexin-specific differences in oligomerization.
J Biol Chem Volume: 277 Page(s): 20911 - 20918
06/07/2002 Authors: Das Sarma J; Wang F; Koval M
Alveolar epithelial barrier function and gap junctional communication are coordinately regulated
FASEB JOURNAL Volume: 16 Page(s): A407 - A408
03/20/2002 Authors: Wang FS; Rueckert P; George P; Koval M
PKC-mediated endocytosis of conjugates targeted to ICAM-1
FASEB JOURNAL Volume: 16 Page(s): A439 - A439
03/20/2002 Authors: Muro S; Thomas AP; Muzykantov VR; Koval M
Size-dependent intracellular immunotargeting of therapeutic cargoes into endothelial cells.
Blood Volume: 99 Page(s): 912 - 922
02/01/2002 Authors: Wiewrodt R; Thomas AP; Cipelletti L; Christofidou-Solomidou M; Weitz DA; Feinstein SI; Schaffer D; Albelda SM; Koval M; Muzykantov VR
Interaction with ZO-1 stabilizes connexin45 in transfected osteoblastic cells
MOLECULAR BIOLOGY OF THE CELL Volume: 12 Page(s): 79A - 79A
11/01/2001 Authors: Laing JG; Manley-Markowski RN; Koval M; Civitelli R; Steinberg TH
Multimeric connexin interactions prior to the trans-Golgi network.
J Cell Sci Volume: 114 Page(s): 4013 - 4024
11/01/2001 Authors: Das Sarma J; Meyer RA; Wang F; Abraham V; Lo CW; Koval M
Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells.
J Biol Chem Volume: 276 Page(s): 23051 - 23055
06/22/2001 Authors: Laing JG; Manley-Markowski RN; Koval M; Civitelli R; Steinberg TH
Heterocellular gap junctional communication between alveolar epithelial cells.
Am J Physiol Lung Cell Mol Physiol Volume: 280 Page(s): L1085 - L1093
06/01/2001 Authors: Abraham V; Chou ML; George P; Pooler P; Zaman A; Savani RC; Koval M
Connexin45 interacts with zonula occludens-1 in osteoblastic cells.
Volume: 8 Page(s): 209 - 212
01/01/2001 Authors: Laing JG; Manley-Markowski RN; Koval M; Civitelli R; Steinberg TH
Cx43/beta-gal inhibits Cx43 transport in the Golgi apparatus.
Cell Commun Adhes Volume: 8 Page(s): 249 - 252
01/01/2001 Authors: Das Sarma J; Lo CW; Koval M
Transfected connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells
MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 227A - 227A
12/01/2000 Authors: Laing JG; Manley-Markowski RN; Koval M; Civitelli R; Steinberg TH
Dominant negative effect of an ER-retained connexin43 construct.
MOLECULAR BIOLOGY OF THE CELL Volume: 11 Page(s): 223A - 224A
12/01/2000 Authors: Das Sarma J; Wang F; Frankel JM; Koval M
Gap junctional communication modulates UTP-induced calcium oscillations InHeLa cells
MOLECULAR BIOLOGY OF THE CELL Volume: 10 Page(s): 404A - 404A
11/01/1999 Authors: Lin GC; Rurangirwa JK; Koval MH; Steinberg TH
Molecular trapping of connexin46 by a dominant negative connexin43 construct.
MOLECULAR BIOLOGY OF THE CELL Volume: 10 Page(s): 403A - 403A
11/01/1999 Authors: Das Sarma J; Abraham V; Lo CW; Koval MH
Regulation of gap junction proteins by alveolar epithelial cells in response to injury.
Chest Volume: 116 Page(s): 35S
07/01/1999 Authors: Abraham V; DeBolt K; Savani R; Koval M
Phenotypic control of gap junctional communication by cultured alveolar epithelial cells.
Am J Physiol Volume: 276 Page(s): L825 - L834
05/01/1999 Authors: Abraham V; Chou ML; DeBolt KM; Koval M
Differential connexin expression by alveolar epithelial cells in culture
MOLECULAR BIOLOGY OF THE CELL Volume: 9 Page(s): 324A - 324A
11/01/1998 Authors: Abraham V; Chou ML; Debolt KM; Koval M
Gap junctional communication modulates gene expression in osteoblastic cells.
Mol Biol Cell Volume: 9 Page(s): 2249 - 2258
08/01/1998 Authors: Lecanda F; Towler DA; Ziambaras K; Cheng SL; Koval M; Steinberg TH; Civitelli R
Size of IgG-opsonized particles determines macrophage response during internalization.
Exp Cell Res Volume: 242 Page(s): 265 - 273
07/10/1998 Authors: Koval M; Preiter K; Adles C; Stahl PD; Steinberg TH
Glucocorticoid regulation of gap junction expression in human fetal lung.
JOURNAL OF INVESTIGATIVE MEDICINE Volume: 46 Page(s): 174A - 174A
01/01/1998 Authors: Koval M; Gonzales LW; Notarfrancesco K; Beers MF; Ballard PL
Cell-specific differences in transport and assembly of connexin46
Page(s): 102 - 106
01/01/1998 Authors: Koval M; Hick E; Harley JE; Steinberg TH
CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion.
Curr Biol Volume: 7 Page(s): 408 - 417
06/01/1997 Authors: Roach T; Slater S; Koval M; White L; Cahir McFarland ED; Okumura M; Thomas M; Brown E
Connexin46 is retained as monomers in a trans-Golgi compartment of osteoblastic cells.
J Cell Biol Volume: 137 Page(s): 847 - 857
05/19/1997 Authors: Koval M; Harley JE; Hick E; Steinberg TH
CD45 transmembrane phosphatase regulates integrin-mediated adhesion and TNF-alpha production in macrophages.
MOLECULAR BIOLOGY OF THE CELL Volume: 7 Page(s): 3428 - 3428
12/01/1996 Authors: Roach TIA; Koval M; CahirMcFarland ED; White L; Okamura M; Thomas ML; Brown EJ
CONNEXIN46 DOES NOT OLIGOMERIZE AND REMAINS IN THE EXOCYTIC PATHWAY OF OSTEOBLASTS
MOLECULAR BIOLOGY OF THE CELL Volume: 6 Page(s): 1739 - 1739
11/01/1995 Authors: KOVAL M; HARLEY JE; HICK E; STEINBERG TH
Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43.
J Cell Biol Volume: 130 Page(s): 987 - 995
08/01/1995 Authors: Koval M; Geist ST; Westphale EM; Kemendy AE; Civitelli R; Beyer EC; Steinberg TH
TRANSFECTED CONNEXIN-45 MODULATES GAP JUNCTIONAL COMMUNICATION IN OSTEOBLASTIC CELLS EXPRESSING ENDOGENOUS CONNEXIN-43
JOURNAL OF BONE AND MINERAL RESEARCH Volume: 10 Page(s): S316 - S316
08/01/1995 Authors: KEMENDY AE; KOVAL M; WESTPHALE EM; STEINBERG TH; BEYER EC; CIVITELLI R
Sphingomyelin synthesis in endosomal compartments?
Trends Cell Biol Volume: 5 Page(s): 148 - 149
04/01/1995 Authors: Koval M; Futerman AH; Pagano RE
Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia.
Biochem J Volume: 301 ( Pt 3) Page(s): 661 - 665
08/01/1994 Authors: Treves S; Larini F; Menegazzi P; Steinberg TH; Koval M; Vilsen B; Andersen JP; Zorzato F
MACROPHAGE (M-PHI) SPREADING BUT NOT PINOCYTOSIS IS PHOSPHOLIPASE (PHASE)-DEPENDENT
FASEB JOURNAL Volume: 8 Page(s): A412 - A412
03/01/1994 Authors: TESLENKO V; ROGERS M; KOVAL M; STEINBERG TH; LEFKOWITH J
ALTERATION OF INTRACELLULAR CA2+ TRANSIENTS IN CELLS TRANSFECTED WITH THE CDNA-ENCODING SKELETAL-MUSCLE RYANODINE RECEPTOR CARRYING A MUTATION ASSOCIATED WITH MALIGNANT HYPERTHERMIA
BIOPHYSICAL JOURNAL Volume: 66 Page(s): A351 - A351
02/01/1994 Authors: LARINI F; ZORZATO F; MENEGAZZI P; STEINBERG TH; KOVAL M; VILSEN B; ANDERSEN J; TREVES S
Endosomal density shift is related to a decrease in fusion capacity.
Eur J Cell Biol Volume: 56 Page(s): 223 - 232
12/01/1991 Authors: Diaz R; Colombo MI; Koval M; Mayorga L; Stahl P
Intracellular transport and metabolism of sphingomyelin.
Biochim Biophys Acta Volume: 1082 Page(s): 113 - 125
03/12/1991 Authors: Koval M; Pagano RE
Analysis of chromosome segregation in Saccharomyces cerevisiae.
Methods Enzymol Volume: 194 Page(s): 749 - 773
01/01/1991 Authors: Shero JH; Koval M; Spencer F; Palmer RE; Hieter P; Koshland D
Sorting of an internalized plasma membrane lipid between recycling and degradative pathways in normal and Niemann-Pick, type A fibroblasts.
J Cell Biol Volume: 111 Page(s): 429 - 442
08/01/1990 Authors: Koval M; Pagano RE
The dynamics of chromosome movement in the budding yeast Saccharomyces cerevisiae.
J Cell Biol Volume: 109 Page(s): 3355 - 3366
12/01/1989 Authors: Palmer RE; Koval M; Koshland D
Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts.
J Cell Biol Volume: 108 Page(s): 2169 - 2181
06/01/1989 Authors: Koval M; Pagano RE
Conformational dynamics of individual DNA molecules during gel electrophoresis.
Nature Volume: 338 Page(s): 520 - 522
04/06/1989 Authors: Schwartz DC; Koval M
Collagenous substrata regulate the nature and distribution of glycosaminoglycans produced by differentiated cultures of mouse mammary epithelial cells.
Exp Cell Res Volume: 156 Page(s): 487 - 499
02/01/1985 Authors: Parry G; Lee EY; Farson D; Koval M; Bissell MJ
GLYCOSAMINOGLYCAN DISTRIBUTION IN DIFFERENTIATED MAMMARY EPITHELIAL-CELLS - RESPONSE TO CULTURE SUBSTRATA
JOURNAL OF CELL BIOLOGY Volume: 97 Page(s): A316 - A316
01/01/1983 Authors: PARRY G; LEE EYH; KOVAL M; FARSON D; BISSELL MJ

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