Masayuki Hirano

Department of Pathology and Laboratory Medicine
Assistant Professor

(404) 727-9588
mhiran2@emory.edu

Academic Appointment

Assistant Professor, Pathology and Laboratory Medicine, Emory University School of Medicine

Education

Degrees

Ph.D. from The University of Tokyo

Research

Focus

The evolution of adaptive immune systems in vertebrates. My current projects especially focus on the analysis of T-like VLRA/VLRC cells and B-like VLRB cells in lampreys.

Publications

Thermostable lamprey variable lymphocyte receptor antibody for detection of Plasmodium falciparum histidine rich protein-2.
Sci Rep Volume: 15 Page(s): 17155
05/17/2025 Authors: Tomar D; Singh B; Hirano M; Senanayake S; Aidoo M; Rogier E; Laur O; Herrin BR; Udhayakumar V
Hagfish genome elucidates vertebrate whole-genome duplication events and their evolutionary consequences.
Nat Ecol Evol Volume: 8 Page(s): 519 - 535
03/01/2024 Authors: Yu D; Ren Y; Uesaka M; Beavan AJS; Muffato M; Shen J; Li Y; Sato I; Wan W; Clark JW
Evolution of two distinct variable lymphocyte receptors in lampreys: VLRD and VLRE.
Cell Rep Volume: 42 Page(s): 112933
08/29/2023 Authors: Das S; Boehm T; Holland SJ; Rast JP; Fontenla-Iglesias F; Morimoto R; Valadez JG; Heimroth RD; Hirano M; Cooper MD
Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates.
Proc Natl Acad Sci U S A Volume: 118
12/14/2021 Authors: Das S; Rast JP; Li J; Kadota M; Donald JA; Kuraku S; Hirano M; Cooper MD
Hypothetical evolutionary models of the variable lymphocyte receptor genes in jawless vertebrates
Volume: 204
05/01/2020 Authors: Das S; Hirano M; Rast J; Cooper MD
Ancient BCMA-like Genes Herald B Cell Regulation in Lampreys.
J Immunol Volume: 203 Page(s): 2909 - 2916
12/01/2019 Authors: Das S; Sutoh Y; Cancro MP; Rast JP; Han Q; Bommakanti G; Cooper MD; Hirano M
BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress.
Cancer Discov Volume: 9 Page(s): 662 - 679
05/01/2019 Authors: Fernando TM; Marullo R; Pera Gresely B; Phillip JM; Yang SN; Lundell-Smith G; Torregroza I; Ahn H; Evans T; Gyrffy B
Evolution of the AID/APOBEC family of cytidine deaminases in lampreys
Volume: 202
05/01/2019 Authors: Hirano M; Sutoh Y; Das S; Cooper M
Cancer Immunity and Gene Expression Data: A Quick Tool for Immunophenotype Evaluation.
Cancer Res Volume: 78 Page(s): 6536 - 6538
12/01/2018 Authors: Hirano M
Evolutionary modification of the VLR-based adaptive immune system in jawless vertebrates: Functional implications
JOURNAL OF IMMUNOLOGY Volume: 200
05/01/2018 Authors: Das S; Li J; Hirano M; Rast J; Cooper MD
Evolution of Alternative Adaptive Immune Systems in Vertebrates.
Volume: 36 Page(s): 19 - 42
04/26/2018 Authors: Boehm T; Hirano M; Holland SJ; Das S; Schorpp M; Cooper MD
LAMPREY MONOCLONAL VLR ANTIBODIES AGAINST PLASMODIUM FALCIPARUM HISTIDINE RICH PROTEIN-2
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Volume: 97 Page(s): 93 - 94
01/01/2017 Authors: Tomar D; Singh B; Rogier E; Hirano M; Laur O; Udhayakumar V; Herrin B; Cooper M
Echinoderm immunity: is the larval immune system immature?
Immunol Cell Biol Volume: 94 Page(s): 809 - 811
10/01/2016 Authors: Hirano M
Characterization of Lamprey BAFF-like Gene: Evolutionary Implications.
J Immunol Volume: 197 Page(s): 2695 - 2703
10/01/2016 Authors: Das S; Sutoh Y; Hirano M; Han Q; Li J; Cooper MD; Herrin BR
Evolution of innate versus adaptive lymphoid cells in vertebrates
EUROPEAN JOURNAL OF IMMUNOLOGY Volume: 46 Page(s): 799 - 799
08/01/2016 Authors: Hirano M; Li J; Rosenberg CS; Cooper MD
Characterization of Lamprey IL-17 Family Members and Their Receptors.
J Immunol Volume: 195 Page(s): 5440 - 5451
12/01/2015 Authors: Han Q; Das S; Hirano M; Holland SJ; McCurley N; Guo P; Rosenberg CS; Boehm T; Cooper MD
Evolution of vertebrate adaptive immunity: immune cells and tissues, and AID/APOBEC cytidine deaminases.
Bioessays Volume: 37 Page(s): 877 - 887
08/01/2015 Authors: Hirano M
Evolution of two prototypic T cell lineages.
Cell Immunol Volume: 296 Page(s): 87 - 94
07/01/2015 Authors: Das S; Li J; Hirano M; Sutoh Y; Herrin BR; Cooper MD
Selection of the lamprey VLRC antigen receptor repertoire.
Proc Natl Acad Sci U S A Volume: 111 Page(s): 14834 - 14839
10/14/2014 Authors: Holland SJ; Gao M; Hirano M; Iyer LM; Luo M; Schorpp M; Cooper MD; Aravind L; Mariuzza RA; Boehm T
Genomic donor cassette sharing during VLRA and VLRC assembly in jawless vertebrates.
Proc Natl Acad Sci U S A Volume: 111 Page(s): 14828 - 14833
10/14/2014 Authors: Das S; Li J; Holland SJ; Iyer LM; Hirano M; Schorpp M; Aravind L; Cooper MD; Boehm T
Cellular and molecular characterization of hagfish VLR-based adaptive immune system
JOURNAL OF IMMUNOLOGY Volume: 192
05/01/2014 Authors: Li J; Guo P; Hirano M; Herrin B; Cooper M
Evolutionary implications of a third lymphocyte lineage in lampreys.
Nature Volume: 501 Page(s): 435 - 438
09/19/2013 Authors: Hirano M; Guo P; McCurley N; Schorpp M; Das S; Boehm T; Cooper MD
Definition of a third VLR gene in hagfish.
Proc Natl Acad Sci U S A Volume: 110 Page(s): 15013 - 15018
09/10/2013 Authors: Li J; Das S; Herrin BR; Hirano M; Cooper MD
Organization of lamprey variable lymphocyte receptor C locus and repertoire development.
Proc Natl Acad Sci U S A Volume: 110 Page(s): 6043 - 6048
04/09/2013 Authors: Das S; Hirano M; Aghaallaei N; Bajoghli B; Boehm T; Cooper MD
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.
Nat Genet Volume: 45 Page(s): 415 - 421e2
04/01/2013 Authors: Smith JJ; Kuraku S; Holt C; Sauka-Spengler T; Jiang N; Campbell MS; Yandell MD; Manousaki T; Meyer A; Bloom OE
Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase.
PLoS Genet Volume: 9 Page(s): e1003736
01/01/2013 Authors: Lada AG; Stepchenkova EI; Waisertreiger ISR; Noskov VN; Dhar A; Eudy JD; Boissy RJ; Hirano M; Rogozin IB; Pavlov YI
AID/APOBEC cytosine deaminase induces genome-wide kataegis.
Biol Direct Volume: 7 Page(s): 47
12/18/2012 Authors: Lada AG; Dhar A; Boissy RJ; Hirano M; Rubel AA; Rogozin IB; Pavlov YI
Immune related genes underpin the evolution of adaptive immunity in jawless vertebrates.
Curr Genomics Volume: 13 Page(s): 86 - 94
04/01/2012 Authors: McCurley N; Hirano M; Das S; Cooper MD
Evolutionary genomics of immunoglobulin-encoding Loci in vertebrates.
Curr Genomics Volume: 13 Page(s): 95 - 102
04/01/2012 Authors: Das S; Hirano M; Tako R; McCallister C; Nikolaidis N
Comparative genomics and genome evolution.
Curr Genomics Volume: 13 Page(s): 85
04/01/2012 Authors: Das S; Hirano M
Evolution of a lymphocyte-based adaptive immune system
Volume: 135 Page(s): 30 - 30
12/01/2011 Authors: Cooper MD; Das S; Guo P; Hirano M; Herrin B; Li J; Nakahara H; McCurley N; Sadlonova A; Yu C
A thymus candidate in lampreys.
Nature Volume: 470 Page(s): 90 - 94
02/03/2011 Authors: Bajoghli B; Guo P; Aghaallaei N; Hirano M; Strohmeier C; McCurley N; Bockman DE; Schorpp M; Cooper MD; Boehm T
Comparative genomics and evolution of immunoglobulin-encoding loci in tetrapods.
Adv Immunol Volume: 111 Page(s): 143 - 178
01/01/2011 Authors: Das S; Hirano M; McCallister C; Tako R; Nikolaidis N
The evolution of adaptive immunity in vertebrates.
Adv Immunol Volume: 109 Page(s): 125 - 157
01/01/2011 Authors: Hirano M; Das S; Guo P; Cooper MD
Comparative genomics and evolution of the alpha-defensin multigene family in primates.
Mol Biol Evol Volume: 27 Page(s): 2333 - 2343
10/01/2010 Authors: Das S; Nikolaidis N; Goto H; McCallister C; Li J; Hirano M; Cooper MD
Analysis of the immunoglobulin light chain genes in zebra finch: evolutionary implications.
Mol Biol Evol Volume: 27 Page(s): 113 - 120
01/01/2010 Authors: Das S; Mohamedy U; Hirano M; Nei M; Nikolaidis N
Dual nature of the adaptive immune system in lampreys.
Nature Volume: 459 Page(s): 796 - 801
06/11/2009 Authors: Guo P; Hirano M; Herrin BR; Li J; Yu C; Sadlonova A; Cooper MD
IgEb immune complexes activate macrophages through FcgammaRIV binding.
Nat Immunol Volume: 8 Page(s): 762 - 771
07/01/2007 Authors: Hirano M; Davis RS; Fine WD; Nakamura S; Shimizu K; Yagi H; Kato K; Stephan RP; Cooper MD
An extended family of Fc receptor relatives.
Eur J Immunol Volume: 35 Page(s): 674 - 680
03/01/2005 Authors: Davis RS; Ehrhardt GRA; Leu C-M; Hirano M; Cooper MD
Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes.
Int Immunol Volume: 16 Page(s): 747 - 757
05/01/2004 Authors: Hirano M; Kikuchi Y; Nisitani S; Yamaguchi A; Satoh A; Ito T; Iba H; Takatsu K
Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition.
Int Immunol Volume: 13 Page(s): 485 - 493
04/01/2001 Authors: Kouro T; Nagata K; Takaki S; Nisitani S; Hirano M; Wahl MI; Witte ON; Karasuyama H; Takatsu K
Mouse BAM11, a novel molecule that binds and regulates Bruton's tyrosine kinase
FASEB JOURNAL Volume: 15 Page(s): A1044 - A1044
03/08/2001 Authors: Hirano M; Kikuchi Y; Nisitani S; Takatsu K
Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk.
Int Immunol Volume: 12 Page(s): 1397 - 1408
10/01/2000 Authors: Kikuchi Y; Hirano M; Seto M; Takatsu K
The carboxyl-terminal region is essential for Sec-A dimerization.
Biochem Biophys Res Commun Volume: 229 Page(s): 90 - 95
12/04/1996 Authors: Hirano M; Matsuyama S; Tokuda H

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Profile

Masayuki Hirano

Academic Appointment

Education

Degrees

Research

Focus

Publications