Publications

• Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy.
  Sci Immunol Volume: 10 Page(s): eadq4973
  02/28/2025 Authors: Klenchin VA; Clark NM; Keles NK; Capuano S; Mason R; Gao G; Broman A; Kose E; Immonen TT; Fennessey CM
• Invivo evolution of env in SHIV-AD8EO-infected rhesus macaques after AAV-vectored delivery of eCD4-Ig.
  Mol Ther Volume: 33 Page(s): 560 - 579
  02/05/2025 Authors: O'Hagan D; Shandilya S; Hopkins LJ; Hahn PA; Fuchs SP; Martinez-Navio JM; Alpert MD; Gardner MR; Desrosiers RC; Gao G
• Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy.
  bioRxiv
  06/03/2024 Authors: Klenchin VA; Clark NM; Keles NK; Capuano S; Mason R; Gao G; Broman A; Kose E; Immonen TT; Fennessey CM
• Developing and Characterizing an AAV Transgene Cassette That Expresses eCD4-Ig and TPST2
  Volume: 31 Page(s): 736 - 737
  05/01/2023 Authors: Leguizamo I; Koroma P; Gardner M
• Seroprevalence of Adeno-Associated Virus Neutralizing Antibodies in Males with Duchenne Muscular Dystrophy.
  Hum Gene Ther Volume: 34 Page(s): 430 - 438
  05/01/2023 Authors: Verma S; Nwosu SN; Razdan R; Upadhyayula SR; Phan HC; Koroma AA; Leguizamo I; Correa NS; Kuipa M; Lee D
• A lentiviral vector B cell gene therapy platform for the delivery of the anti-HIV-1 eCD4-Ig-knob-in-hole-reversed immunoadhesin.
  Mol Ther Methods Clin Dev Volume: 28 Page(s): 366 - 384
  03/09/2023 Authors: Vamva E; Ozog S; Leaman DP; Yu-Hong Cheng R; Irons NJ; Ott A; Stoffers C; Khan I; Goebrecht GKE; Gardner MR
• A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors.
  Front Immunol Volume: 14 Page(s): 1105617
  01/01/2023 Authors: Davis-Gardner ME; Weber JA; Xie J; Pekrun K; Alexander EA; Weisgrau KL; Furlott JR; Rakasz EG; Kay MA; Gao G
• Development of a lentiviral vector mediated B cell gene therapy platform for the delivery of therapeutic anti-HIV-1 eCD4-Ig immunoadhesin
  Volume: 33 Page(s): A159 - A159
  12/01/2022 Authors: Vamva E; Ozog S; Leaman D; Cheng R; Irons NJ; Ott A; Goebrecht GKE; Gardner MR; Farzan M; Rawlings DJ
• A Direct Comparison of Five AAV Capsids for Intramuscular Inoculation in Non-Human Primates
  Volume: 30 Page(s): 207 - 207
  04/01/2022 Authors: Gardner MR; Farzan M
• High concordance of ELISA and neutralization assays allows for the detection of antibodies to individual AAV serotypes.
  Mol Ther Methods Clin Dev Volume: 24 Page(s): 199 - 206
  03/10/2022 Authors: Gardner MR; Mendes DE; Muniz CP; Martinez-Navio JM; Fuchs SP; Gao G; Desrosiers RC
• Estimation of the in vivo neutralization potency of eCD4Ig and conditions for AAV-mediated production for SHIV long-term remission.
  Sci Adv Volume: 8 Page(s): eabj5666
  01/14/2022 Authors: Goyal A; Gardner M; Mayer BT; Jerome KR; Farzan M; Schiffer JT; Cardozo-Ojeda EF
• Primary B cell restricted eCD4-Ig expression through lentiviral vector delivery supports HIV-1 neutralisation
  Volume: 32 Page(s): A99 - A100
  10/01/2021 Authors: Vamva E; Ozog S; Leaman D; Ott A; Gardner MR; Goebrecht GKE; Farzan M; Rawlings D; Zwick M; James R
• Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2.
  PLoS Pathog Volume: 17 Page(s): e1009501
  04/01/2021 Authors: Mou H; Quinlan BD; Peng H; Liu G; Guo Y; Peng S; Zhang L; Davis-Gardner ME; Gardner MR; Crynen G
• Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2.
  bioRxiv
  06/30/2020 Authors: Mou H; Quinlan BD; Peng H; Guo Y; Peng S; Zhang L; Davis-Gardner ME; Gardner MR; Crynen G; Voo ZX
• A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies.
  mBio Volume: 11
  01/14/2020 Authors: Davis-Gardner ME; Alfant B; Weber JA; Gardner MR; Farzan M
• Promise and Progress of an HIV-1 Cure by Adeno-Associated Virus Vector Delivery of Anti-HIV-1 Biologics.
  Front Cell Infect Microbiol Volume: 10 Page(s): 176
  01/01/2020 Authors: Gardner MR
• AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges.
  Sci Transl Med Volume: 11
  07/24/2019 Authors: Gardner MR; Fellinger CH; Kattenhorn LM; Davis-Gardner ME; Weber JA; Alfant B; Zhou AS; Prasad NR; Kondur HR; Newton WA
• eCD4-Ig Limits HIV-1 Escape More Effectively than CD4-Ig or a Broadly Neutralizing Antibody.
  J Virol Volume: 93
  07/15/2019 Authors: Fellinger CH; Gardner MR; Weber JA; Alfant B; Zhou AS; Farzan M
• Associating HIV-1 envelope glycoprotein structures with states on thevirus observed by smFRET.
  Nature Volume: 568 Page(s): 415 - 419
  04/01/2019 Authors: Lu M; Ma X; Castillo-Menendez LR; Gorman J; Alsahafi N; Ermel U; Terry DS; Chambers M; Peng D; Zhang B
• Anti-drug Antibody Responses Impair Prophylaxis Mediated by AAV-Delivered HIV-1 Broadly Neutralizing Antibodies.
  Mol Ther Volume: 27 Page(s): 650 - 660
  03/06/2019 Authors: Gardner MR; Fetzer I; Kattenhorn LM; Davis-Gardner ME; Zhou AS; Alfant B; Weber JA; Kondur HR; Martinez-Navio JM; Fuchs SP
• A Coreceptor-Mimetic Peptide Enhances the Potency of V3-Glycan Antibodies.
  J Virol Volume: 93
  03/01/2019 Authors: Fetzer I; Davis-Gardner ME; Gardner MR; Alfant B; Weber JA; Prasad NR; Zhou AS; Farzan M
• eCD4-Ig Is More Difficult to Escape Than Broadly Neutralizing Antibodies
  Volume: 34 Page(s): 78 - 78
  10/01/2018 Authors: Fellinger CH; Gardner MR; Alfant B; Weber JA; Farzan M
• Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies.
  PLoS Pathog Volume: 14 Page(s): e1007238
  08/01/2018 Authors: Otsuka Y; Schmitt K; Quinlan BD; Gardner MR; Alfant B; Reich A; Farzan M; Choe H
• eCD4-Ig Variants That More Potently Neutralize HIV-1.
  J Virol Volume: 92
  06/15/2018 Authors: Fetzer I; Gardner MR; Davis-Gardner ME; Prasad NR; Alfant B; Weber JA; Farzan M
• Conditional Regulation of Gene Expression by Ligand-Induced Occlusion of a MicroRNA Target Sequence.
  Mol Ther Volume: 26 Page(s): 1277 - 1286
  05/02/2018 Authors: Mou H; Zhong G; Gardner MR; Wang H; Wang Y-W; Cheng D; Farzan M
• B-Cell Lineage Restricted eCD4-Ig Expression for HIV Prophylaxis via Lentiviral Vector Mediated CD34 Cell Transduction
  Volume: 26 Page(s): 243 - 243
  05/01/2018 Authors: Ozog S; Gardner M; Hermann K; Chen C; Garijo O; Rawlings D; Farzan M; Torbett B
• Evaluating Effector Function as a Determinant of ADA against AAV-Delivered Antibodies
  Volume: 26 Page(s): 321 - 322
  05/01/2018 Authors: Davis-Gardner ME; Gardner MR; Fetzer I; Farzan M
• AAV-Delivered eCD4-Ig Protects Rhesus Macaques from High Dose SIVmac239 Challenges
  Volume: 26 Page(s): 235 - 236
  05/01/2018 Authors: Gardner MR; Fellinger CH; Weber JA; Alfant B; Farzan M
• HIV-1 inhibitory properties of eCD4-Igmim2 determined using an Env-mediated membrane fusion assay.
  PLoS One Volume: 13 Page(s): e0206365
  01/01/2018 Authors: Yang E; Gardner MR; Zhou AS; Farzan M; Arvin AM; Oliver SL
• eCD4-Ig promotes ADCC activity of sera from HIV-1-infected patients.
  PLoS Pathog Volume: 13 Page(s): e1006786
  12/01/2017 Authors: Davis-Gardner ME; Gardner MR; Alfant B; Farzan M
• Simian Immunodeficiency Virus SIVmac239, but Not SIVmac316, Binds and Utilizes Human CD4 More Efficiently than Rhesus CD4.
  J Virol Volume: 91
  09/15/2017 Authors: Fellinger CH; Gardner MR; Bailey CC; Farzan M
• Engineering antibody-like inhibitors to prevent and treat HIV-1 infection.
  Curr Opin HIV AIDS Volume: 12 Page(s): 294 - 301
  05/01/2017 Authors: Gardner MR; Farzan M
• CD4-Induced Antibodies Promote Association of the HIV-1 Envelope Glycoprotein with CD4-Binding Site Antibodies.
  J Virol Volume: 90 Page(s): 7822 - 7832
  09/01/2016 Authors: Gardner MR; Fellinger CH; Prasad NR; Zhou AS; Kondur HR; Joshi VR; Quinlan BD; Farzan M
• Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques.
  Proc Natl Acad Sci U S A Volume: 113 Page(s): E3413 - E3422
  06/14/2016 Authors: Li H; Wang S; Kong R; Ding W; Lee F-H; Parker Z; Kim E; Learn GH; Hahn P; Policicchio B
• Envelope Glycoprotein Internalization Protects Human and Simian Immunodeficiency Virus-Infected Cells from Antibody-Dependent Cell-Mediated Cytotoxicity.
  J Virol Volume: 89 Page(s): 10648 - 10655
  10/01/2015 Authors: von Bredow B; Arias JF; Heyer LN; Gardner MR; Farzan M; Rakasz EG; Evans DT
• Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision.
  Neuron Volume: 87 Page(s): 1248 - 1260
  09/23/2015 Authors: Cao Y; Sarria I; Fehlhaber KE; Kamasawa N; Orlandi C; James KN; Hazen JL; Gardner MR; Farzan M; Lee A
• AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.
  Nature Volume: 519 Page(s): 87 - 91
  03/05/2015 Authors: Gardner MR; Kattenhorn LM; Kondur HR; von Schaewen M; Dorfman T; Chiang JJ; Haworth KG; Decker JM; Alpert MD; Bailey CC
• A double-mimetic peptide efficiently neutralizes HIV-1 by bridging the CD4- and coreceptor-binding sites of gp120.
  J Virol Volume: 88 Page(s): 3353 - 3358
  03/01/2014 Authors: Quinlan BD; Joshi VR; Gardner MR; Ebrahimi KH; Farzan M
• Direct expression and validation of phage-selected peptide variants in mammalian cells.
  J Biol Chem Volume: 288 Page(s): 18803 - 18810
  06/28/2013 Authors: Quinlan BD; Gardner MR; Joshi VR; Chiang JJ; Farzan M
• Enhanced recognition and neutralization of HIV-1 by antibody-derived CCR5-mimetic peptide variants.
  J Virol Volume: 86 Page(s): 12417 - 12421
  11/01/2012 Authors: Chiang JJ; Gardner MR; Quinlan BD; Dorfman T; Choe H; Farzan M
• Pathogenesis of Lymantria dispar multiple nucleopolyhedrovirus in L. dispar and mechanisms of developmental resistance.
  J Gen Virol Volume: 91 Page(s): 1590 - 1600
  06/01/2010 Authors: McNeil J; Cox-Foster D; Gardner M; Slavicek J; Thiem S; Hoover K