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Profile

Manila Gaddh

  • Department of Hematology and Medical Oncology
    Associate Professor
  • manila.gaddh@emory.edu
Head shot of Manila Gaddh

Academic Appointment

  • Associate Professor, Department of Hematology and Medical Oncology, Emory University School of Medicine

Education

Degrees

  • MBBS from Lady Hardinge Medical College

Research

Focus

  • My research focus is on thrombosis in cancer patients and bone marrow failure syndromes. I am currently involved in developing an evidence-based algorithmic approach to evaluation of thrombotic disorders, and am working towards exploring the feasibility of novel therapies, including combined thrombectomy and low dose anticoagulation, for treatment of thrombosis in cancer patients.

Publications

  • Efficacy and safety of direct oral anticoagulants compared with warfarin in antiphospholipid syndrome. Results of a multicenter retrospective cohort study.
    Res Pract Thromb Haemost Volume: 9 Page(s): 102856
    05/01/2025 Authors: Elsebaie MAT; Wickham Z; DeBragga S; Fedewa S; Amgad M; Park JJ; Li A; Eshaghpour A; Li J; Crowther M
  • Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial: Effect on 3-Month Symptoms and Quality of Life.
    Chest Volume: 165 Page(s): 785 - 799
    04/01/2024 Authors: Greenstein YY; Hubel K; Froess J; Wisniewski SR; Venugopal V; Lai Y-H; Berger JS; Chang SY; Colovos C; Shah F
  • Combined immunosuppression for acquired hemophilia A: CyDRi is a highly effective low-toxicity regimen.
    Blood Volume: 140 Page(s): 1983 - 1992
    11/03/2022 Authors: Simon B; Cegldi A; Dolgos J; Farkas P; Gaddh M; Hank L; Horvth R; Kaposi A; Magyar L; Masszi T
  • Comparing direct oral anticoagulants and vitamin K antagonist use in morbidly obese patients with venous thromboembolism: A single center retrospective cohort study.
    EJHaem Volume: 3 Page(s): 457 - 462
    05/01/2022 Authors: Scott LC; Li J; Cafuir LA; Gaddh M; Kempton CL
  • Physician perceptions and use of reduced-dose direct oral anticoagulants for extended phase venous thromboembolism treatment.
    Res Pract Thromb Haemost Volume: 6 Page(s): e12740
    05/01/2022 Authors: Groat D; Martin KA; Rosovsky RP; Sanfilippo KM; Gaddh M; Kreuziger LB; Eyster ME; Woller SC; Venous thromboEmbolism Network US (VENUS) VTE Treatment, Anticoagulation Management Group
  • Preliminary Analysis of the Association Between Therapeutic-Dose Anticoagulation and Long Term Outcomes from the ACTIV-4a and ATTACC Multiplatform Adaptive Trial of Hospitalized Patients with COVID-19
    Volume: 205
    05/01/2022 Authors: Greenstein YY; Hubel K; Venugopal V; Lai Y; Berger JS; Chang SY; Colovos C; Shah FA; Islam M; Ceja JJ
  • Preliminary Analysis of the Symptoms and Quality of Life After Discharge in Noncritically Ill Patients with COVID-19: The ACTIV-4a and ATTACC Randomized Controlled Trial
    Volume: 205
    05/01/2022 Authors: Hubel KA; Greenstein YY; Venugopal V; Lai Y; Berger JS; Chang SY; Colovos C; Shah F; Islam M; Jimenez J
  • Clinical Outcomes of Critically III Patients with COVID-19 by Race.
    J Racial Ethn Health Disparities Volume: 9 Page(s): 385 - 389
    04/01/2022 Authors: Marmarchi F; Liu M; Rangaraju S; Auld SC; Creel-Bulos MC; Kempton CL; Sharifpour M; Gaddh M; Sniecinski R; Maier CL
  • Anticoagulation in cancer-associated thromboembolism with thrombocytopenia: a prospective, multicenter cohort study.
    Blood Adv Volume: 5 Page(s): 5546 - 5553
    12/28/2021 Authors: Carney BJ; Wang T-F; Ren S; George G; Al Homssi A; Gaddh M; Connolly GC; Shah VI; Bogue T; Bartosic A
  • County-Level Social Vulnerability Is Associated with Increased Risk for Venous Thromboembolism in COVID-19
    Volume: 233 Page(s): S319 - S319
    11/01/2021 Authors: Meena RA; Di M; Wiley Z; Gaddh M; Patzer RE; Alabi O
  • Immune thrombocytopenia in 2 healthy young women after the Pfizer-BioNTech BNT16B2b2 messenger RNA coronavirus disease 2019 vaccination.
    J Am Coll Emerg Physicians Open Volume: 2 Page(s): e12531
    10/01/2021 Authors: Collins EC; Carr MJ; Kim JS; Lewis J; Maleque N; Desai K; Chen L; Sevransky J; Gaddh M; Rouphael N
  • COVID-19-associated venous thromboembolism portends worse survival.
    Semin Vasc Surg Volume: 34 Page(s): 117 - 124
    09/01/2021 Authors: Meena RA; Sharifpour M; Gaddh M; Cui X; Xie Y; Di M; Brewster LP; Duwayri Y; Alabi O
  • The Coronavirus Disease 2019 Likelihood of Thrombosis Calculator: Predicting Venous Thromboembolism Risk in Hospitalized Patients With Coronavirus Disease 2019
    Volume: 74 Page(s): E84 - E86
    09/01/2021 Authors: Meena RA; Di M; Patzer RE; Gaddh M; Nahab FB; Alabi O
  • Interdisciplinary Approach to Thrombosis Management in COVID-19 at a Large Academic Center.
    JCO Oncol Pract Volume: 17 Page(s): 517 - 521
    09/01/2021 Authors: Gaddh M; Maier CL
  • Risk of pulmonary emboli after removal of an upper extremity central catheter associated with a deep vein thrombosis.
    Blood Adv Volume: 5 Page(s): 2807 - 2812
    07/27/2021 Authors: Houghton DE; Billett HH; Gaddh M; Onadeko O; George G; Wang T-F; Oo TH; Feng M; Dasgupta M; Jaglal M
  • Treatment of catheter-related thrombosis in patients with hematologic malignancies: A Venous thromboEmbolism Network U.S. retrospective cohort study.
    Thromb Res Volume: 202 Page(s): 155 - 161
    06/01/2021 Authors: Baumann Kreuziger L; Gaddh M; Onadeko O; George G; Wang T-F; Oo TH; Jaglal M; Houghton DE; Streiff MB; Gali R
  • North American Physician Practice Patterns in the Management of Anticoagulation in Pregnancy.
    J Womens Health (Larchmt) Volume: 30 Page(s): 829 - 836
    06/01/2021 Authors: Cohen AJ; Boggio L; Billett HH; DeSancho MT; Gaddh M; Kouides P; Lim M; Nyak L; Rajan S; Rosovsky R
  • Therapeutic plasma exchange for COVID-19-associated hyperviscosity.
    Transfusion Volume: 61 Page(s): 1029 - 1034
    04/01/2021 Authors: Truong AD; Auld SC; Barker NA; Friend S; Wynn AT; Cobb J; Sniecinski RM; Tanksley C-L; Polly DM; Gaddh M
  • Venous Thromboembolism: Genetics and Thrombophilias.
    Semin Respir Crit Care Med Volume: 42 Page(s): 271 - 283
    04/01/2021 Authors: Gaddh M; Rosovsky RP
  • Comanagement Strategy Between Academic Institutions and Community Practices to Reduce Induction Mortality in Acute Promyelocytic Leukemia.
    JCO Oncol Pract Volume: 17 Page(s): e497 - e505
    04/01/2021 Authors: Jillella AP; Arellano ML; Gaddh M; Langston AA; Heffner LT; Winton EF; McLemore ML; Zhang C; Caprara CR; Simon KS
  • Markers of Coagulation and Hemostatic Activation Identify Covid-19 Patients at High Risk for Thrombotic Events
    Volume: 52
    03/01/2021 Authors: Alabyad D; Rangaraju S; Liu M; Imran R; Kempton CL; Sharifpour M; Auld SC; Gaddh M; Sniecinski R; Maier CL
  • A Tale of Two Surges: Improved Mortality During Second Wave of COVID-19 Infections
    Volume: 73 Page(s): E47 - E47
    03/01/2021 Authors: Meena RA; Di M; Cui X; Xie Y; Ramos CR; Duwayri Y; Gaddh M; Alabi O
  • Fibrinolysis Shutdown and Thrombosis in a COVID-19 ICU.
    Shock Volume: 55 Page(s): 316 - 320
    03/01/2021 Authors: Creel-Bulos C; Auld SC; Caridi-Scheible M; Barker NA; Friend S; Gaddh M; Kempton CL; Maier CL; Nahab F; Sniecinski R
  • Validation of an admission coagulation panel for risk stratification of COVID-19 patients.
    PLoS One Volume: 16 Page(s): e0248230
    01/01/2021 Authors: Alabyad D; Rangaraju S; Liu M; Imran R; Kempton CL; Sharifpour M; Auld SC; Gaddh M; Sniecinski R; Maier CL
  • Trends and diagnostic value of D-dimer levels in patients hospitalized with coronavirus disease 2019.
    Medicine (Baltimore) Volume: 99 Page(s): e23186
    11/13/2020 Authors: Creel-Bulos C; Liu M; Auld SC; Gaddh M; Kempton CL; Sharifpour M; Sniecinski RM; Maier CL; Nahab FB; Rangaraju S
  • Clinician-ordered peripheral blood smears have low reimbursement and variable clinical value: a three-institution study, with suggestions for operational efficiency.
    Diagn Pathol Volume: 15 Page(s): 112
    09/17/2020 Authors: Beckman AK; Ng VL; Jaye DL; Gaddh M; Williams SA; Yohe SL; Zhang L; Linden MA
  • Clinical Utilization and Cost of Thrombophilia Testing in Patients with Venous Thromboembolism.
    TH Open Volume: 4 Page(s): e153 - e162
    07/01/2020 Authors: Gaddh M; Cheng E; Elsebaie MAT; Bod I
  • Corrigendum to "Edoxaban for treatment of venous thromboembolism in patient groups with different types of cancer: Results from the Hokusai VTE Cancer study" [Thromb. Res. vol. 185, January 2020, pages 13-19].
    Thromb Res Volume: 191 Page(s): 156 - 159
    07/01/2020 Authors: Mulder FI; van Es N; Kraaijpoel N; Di Nisio M; Carrier M; Duggal A; Gaddh M; Garcia D; Grosso MA; Kakkar AK
  • Outcomes of Chronic Phase Chronic Myeloid Leukemia after Treatment with Multiple Tyrosine Kinase Inhibitors.
    J Clin Med Volume: 9
    05/20/2020 Authors: Kong JH; Winton EF; Heffner LT; Gaddh M; Hill B; Neely J; Hatcher A; Joseph M; Arellano M; El-Rassi F
  • Carden MA, Gaddh M, Hoskote A, et al. Rituximab leads to early elimination of circulating CD20+ T and B lymphocytes in patients with iTTP despite ongoing TPEx. Blood Adv. 2020;4(3):477-481.
    Blood Adv Volume: 4 Page(s): 1093
    03/24/2020
  • Rituximab leads to early elimination of circulating CD20+ T and B lymphocytes in patients with iTTP despite ongoing TPEx.
    Blood Adv Volume: 4 Page(s): 477 - 481
    02/11/2020 Authors: Carden MA; Gaddh M; Hoskote A; Brown M; Merrill V; Stowell SR; Chandrakasan S; Antun A; Kudchadkar R; Kotanchiyev S
  • An uncommon presentation of chronic myeloid leukemia.
    Ann Hematol Volume: 99 Page(s): 357 - 358
    02/01/2020 Authors: Christiansen JS; Gaddh M; Wells J
  • Edoxaban for treatment of venous thromboembolism in patient groups with different types of cancer: Results from the Hokusai VTE Cancer study.
    Thromb Res Volume: 185 Page(s): 13 - 19
    01/01/2020 Authors: Mulder FI; van Es N; Kraaijpoel N; Di Nisio M; Carrier M; Duggal A; Gaddh M; Garcia D; Grosso MA; Kakkar AK
  • ERRATUM: Managing acute promyelocytic leukemia in patients belonging to the Jehovah's Witness congregation.
    Hematol Rep Volume: 11 Page(s): 8395
    11/29/2019 Authors: Jillella AP; Arellano ML; Heffner LT; Gaddh M; Langston AA; Khoury HJ; Mangaonkar A; Kota VK
  • Optimal Timing for Removal of an Upper Extremity Central Catheter When Associated with a Deep Vein Thrombosis: A Venous Thromboembolism Network US Multicenter Retrospective Cohort Study
    Volume: 134
    11/13/2019 Authors: Houghton DE; Billett HHH; Gaddh M; Onadeko O; George G; Wang T-F; Oo TH; Sun Y; Feng M; Jaglal M
  • Follow-up to comment on "Direct Oral Anticoagulants in Patients with Venous Thromboembolism and Thrombophilia: Systematic Review and Meta-Analysis".
    J Thromb Haemost Volume: 17 Page(s): 1007 - 1009
    06/01/2019 Authors: Elsebaie MAT; Van Es N; Langston A; Bller HR; Gaddh M
  • Direct oral anticoagulants in patients with venous thromboembolism and thrombophilia: a systematic review and meta-analysis.
    Volume: 17 Page(s): 645 - 656
    04/01/2019 Authors: Elsebaie MAT; van Es N; Langston A; Bller HR; Gaddh M
  • Wide Variation in Duration of Anticoagulation after Catheter-Related Thrombosis: A Venous Thromboembolism Network US Multicenter Retrospective Cohort Study
    Volume: 132
    11/29/2018 Authors: Kreuziger LB; Gaddh M; Onadeko O; George G; Wang T-F; Oo TH; Feng M; Simpson P; Gali R; Billett HH
  • TREATMENT OF VENOUS THROMBOEMBOLISM DURING INDUCTION CHEMOTHERAPY IN PATIENTS WITH ACUTE LEUKEMIA: A SINGLE CENTER EXPERIENCE
    Volume: 93 Page(s): E51 - E51
    09/01/2018 Authors: Patel B; Cheng E; McLemore M; Arellano M; Heffner LT; Winton EF; Bodo I; Langston A; Kota V; Gaddh M
  • Incidence and Predictors of Left Ventricular Dysfunction Among Acute Myeloid Leukemia Patients
    Volume: 130
    12/07/2017 Authors: Almuwaqqat Z; Gaddh M; Schlafer D; Hutcherson D; Arellano ML; Parashar S; Kota V
  • Outcomes of Chronic Phase Chronic Myeloid Leukemia (CP-CML) after Sequential Treatment with Tyrosine Kinase Inhibitors (TKI)
    Volume: 130
    12/07/2017 Authors: Kong JH; Winton EF; Heffner L; Gaddh M; Hill B; Arellano ML; El-Rassi F; Kim A; Kota V
  • Outcomes after Sequential Tyrosine Kinase Inhibitors Treatment in Chronic Phase Chronic Myeloid Leukemia
    Volume: 130
    12/07/2017 Authors: Kong JH; Winton EF; Heffner L; Gaddh M; Hill B; Arellano M; El-Rassi F; Kim A; Jillella A; Kota VK
  • Outcomes of Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia Following an Elective Switch From Second-Generation Tyrosine Kinase Inhibitor to Imatinib.
    Clin Lymphoma Myeloma Leuk Volume: 17 Page(s): e71 - e73
    12/01/2017 Authors: Kota VK; Kong JH; Arellano M; El Rassi F; Gaddh M; Heffner LT; Winton EF; Jillella AP; McLemore ML; Khoury HJ
  • Managing acute promyelocytic leukemia in patients belonging to the Jehovah's Witness congregation.
    Hematol Rep Volume: 9 Page(s): 7083
    09/26/2017 Authors: Jillella AP; Arellano ML; Heffner LT; Gaddh M; Langston AA; Khoury HJ; Mangoankar A; Kota VK
  • Cost of Thrombophilia Workup At a Tertiary Care Hospital
    Volume: 23 Page(s): 11 - 12
    04/01/2017 Authors: Cheng E; Lin Y; Bodo I; Gaddh M
  • Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin.
    Oncogene Volume: 36 Page(s): 254 - 262
    01/12/2017 Authors: Elf S; Lin R; Xia S; Pan Y; Shan C; Wu S; Lonial S; Gaddh M; Arellano ML; Khoury HJ
  • Outcomes of Chronic Phase Chronic Myeloid Leukemia Patients Following Tyrosine Kinase Inhibitors Dose-Reductions
    Volume: 128
    12/02/2016 Authors: Kong JH; Khoury HJ; Winton EF; Heffner LT; Gaddh M; Arellano M; El-Rassi F; Kim AS; Jillella A; Bodo I
  • Tetrameric Acetyl-CoA Acetyltransferase 1 Is Important for Tumor Growth.
    Mol Cell Volume: 64 Page(s): 859 - 874
    12/01/2016 Authors: Fan J; Lin R; Xia S; Chen D; Elf SE; Liu S; Pan Y; Xu H; Qian Z; Wang M
  • DECREASING EARLY DEATHS IN ACUTE PROMYELOCYTIC LEUKEMIA (APL) IN AN ACADEMIC CENTER IN THE US BY USING A SIMPLIFIED TREATMENT ALGORITHM AND DEDICATED APL EXPERTS
    Volume: 101 Page(s): 675 - 676
    06/01/2016 Authors: Jillella A; Mody M; Harpaul G; Arellano M; Khoury H; Al-Kadhimi Z; McLemore M; Winton E; Gaddh M; Heffner L
  • Costs associated with induction chemotherapy in adult acute myeloid leukemia (AML) managed in a tertiary care specialized unit.
    Volume: 34
    05/20/2016 Authors: Gleason S; Howard DH; Liu Y; Goldstein DA; Arellano ML; Jillella AP; Gaddh M; Kota V; Winton EF; Heffner LT
  • Decreasing Early Deaths in Acute Promyelocytic Leukemia (APL) By Using a Simplified Treatment Algorithm and Establishing a Network with Academic and Community Centers in USA
    Volume: 126
    12/03/2015 Authors: Jillella A; Arellano M; Bashey A; Vidito SI; Stuart RK; Leung C; Sitchenko K; Gaddh M; Heffner LT; Kolhe RB
  • Survival of Patients Diagnosed with Primary Refractory and Relapsed Acute Myeloid Leukemia from 2008-2012: A Single Institution Experience
    Volume: 126
    12/03/2015 Authors: Zeichner SB; Gleason S; Antun AG; Langston A; Heffner LT; Kota VK; Gaddh M; Arellano M
  • Predicting early blast transformation in chronic-phase chronic myeloid leukemia: is immunophenotyping the missing link?
    Cancer Volume: 121 Page(s): 872 - 875
    03/15/2015 Authors: El Rassi F; Bergsagel JD; Arellano M; Gaddh M; Jillella A; Kota V; Heffner LT; Winton EF; Khoury HJ
  • Peripheral T Cell Lymphoma Masquerading As Asthma And Eosinophilia
    Volume: 191
    01/01/2015 Authors: Egea E; Sica G; Gaddh M; Bag R; Lee F-H
  • Disposable platform provides visual and color-based point-of-care anemia self-testing.
    J Clin Invest Volume: 124 Page(s): 4387 - 4394
    10/01/2014 Authors: Tyburski EA; Gillespie SE; Stoy WA; Mannino RG; Weiss AJ; Siu AF; Bulloch RH; Thota K; Cardenas A; Session W
  • Early Blast Phase Transformation In Chronic Phase Chronic Myeloid Leukemia: Is Flow Cytometry The Missing Link?
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA Volume: 14 Page(s): S136 - S137
    09/01/2014 Authors: El Rassi F; Arellano M; Winton E; Heffner L; Gaddh M; Khoury HJ
  • Venous access catheter-related thrombosis in patients with cancer.
    Leuk Lymphoma Volume: 55 Page(s): 501 - 508
    03/01/2014 Authors: Gaddh M; Antun A; Yamada K; Gupta P; Tran H; El Rassi F; Kim HS; Khoury HJ
  • Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex.
    Mol Cell Volume: 53 Page(s): 534 - 548
    02/20/2014 Authors: Fan J; Shan C; Kang H-B; Elf S; Xie J; Tucker M; Gu T-L; Aguiar M; Lonning S; Chen H
  • Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies.
    Cancer Volume: 119 Page(s): 3784 - 3787
    11/01/2013 Authors: Antun AG; Gleason S; Arellano M; Langston AA; McLemore ML; Gaddh M; el Rassi F; Bernal-Mizrachi L; Galipeau J; Heffner LT
  • Evaluation of 4Tscore and Polytypic Solid-Phase Elisa Test in the Diagnosis of Heparin-Induced Thrombocytopenia
    AMERICAN JOURNAL OF HEMATOLOGY Volume: 87 Page(s): S172 - S172
    05/01/2012 Authors: Gaddh M; Poola H; Jain P; Velinova S; Kovarik P; Telfer M; Catchatourian R
  • Frequency of Kras mutation in colorectal cancer patients in a minority-based population at a community clinical oncology program (CCOP)-participating inner-city hospital.
    JOURNAL OF CLINICAL ONCOLOGY Volume: 29
    05/20/2011 Authors: Gaddh M; Poola HV; Batra KK; Mullane MR; Sekosan M; Lad TE
  • Frequency distribution of hepatitis C infection among patients with B-cell non-Hodgkin lymphoma in underserved minority population
    JOURNAL OF CLINICAL ONCOLOGY Volume: 29
    05/20/2011 Authors: Adab K; Chongpison Y; Patel AV; Gaddh M; Braik T; Haidau A; Poola HV; Nathan S; Telfer MC; Catchatourian R
  • Single 4.5mg Dose of Rasburicase for Tumor Lysis Syndrome In Adults
    Volume: 116 Page(s): 741 - 742
    11/19/2010 Authors: Yim B; Navaleza A; Haidau A; Sreenivasappa S; Kassem MA; Ciobanu BC; Braik T; Gaddh M; Rubinstein PG; Shah M
  • Clinical presentation characteristics and prognosis of urban, minority patients presenting with triple-negative breast cancer: An observational 5-year case review
    Volume: 26
    05/20/2008 Authors: Nathan S; Patel P; Gaddh M; Yim B; Zayat V; Ferrer K; Sekosan M; Samuel J
  • Retrospective review of hypercoagulability in minority populations at an inner city hospital's general hematology clinic
    Volume: 110 Page(s): 61B - 61B
    11/16/2007 Authors: Patel PR; Gaddh M; Nathan S; Decebal G; Catchatourian R; Telfer MC
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