Arthur English PhD
Overview
My research program investigates recovery from peripheral nerve injuries. We study this at three levels. First, the enhancement of axon regeneration following nerve injuries using moderate exercise is being studied in genetically manipulated mice. Of particular interest is the interaction of neuronal activity, gonadal hormones, and neurotrophins. Second, we study the plasticity of synapses in the spinal cord following nerve injury and whether exercise can reverse injury-induced changes. Of special interest is the role of axonal protein synthesis. Finally, we study the effects of exercise on functional recovery after nerve injury as part of a PPG from the National Center for Medical Rehabilitation Research of NICHD.
Lab Personnel
Postdoctoral fellows: Patricia J. Ward, Poonam Jaiswal (http://www.researchgate.net/profile/Poonam_Jaiswal4)
Grad students: Kristen Sanders, Claire McGregor
Academic Appointment
Education
Degrees
- PhD from University of Illinois Medical Center
- BS from University of Oregon
- BS from University of Illinois Medical Center
Research
Publications
-
Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration.
Proc Natl Acad Sci U S A Volume: 122 Page(s): e2411811122
03/04/2025 Authors: Sahoo PK; Agrawal M; Hanovice N; Ward PJ; Desai M; Smith TP; SiMa H; Dulin JN; Vaughn LS; Tuszynski MH -
GABA and Glycine Synaptic Release on Axotomized Motoneuron Cell Bodies Promotes Motor Axon Regeneration.
Eur J Neurosci Volume: 61 Page(s): e70045
03/01/2025 Authors: Wood RL; Calvo PM; McCallum WM; English AW; Alvarez FJ -
Water-circulating probes significantly modify lesion length and axon damage in cooled radiofrequency ablations when compared with similar-sized standard radiofrequency probes in rats.
Reg Anesth Pain Med Volume: 49 Page(s): 448 - 454
06/03/2024 Authors: Cobbs A; Alas G; Yadav R; Mayeux J; Eckmann MS; Provenzano DA; English AW; Washington A; Wang R -
Air-stepping in the neonatal mouse: a powerful tool for analyzing early stages of rhythmic limb movement development.
J Neurophysiol Volume: 131 Page(s): 321 - 337
02/01/2024 Authors: Mistretta OC; Wood RL; English AW; Alvarez FJ -
Treatments with the specific -secretase inhibitor, compound 11, promote the regeneration of motor and sensory axons after peripheral nerve injury.
Eur J Neurosci Volume: 58 Page(s): 3555 - 3568
09/01/2023 Authors: Isaacson RH; Carrasco DI; Holliday H; Kang SS; Khan S; Kim D; Liu X; Ye K; English AW -
Proportions of four distinct classes of sensory neurons are retained even when axon regeneration is enhanced following peripheral nerve injury.
Front Neuroanat Volume: 17 Page(s): 1303888
01/01/2023 Authors: Khan S; Carrasco DI; Isaacson R; English AW -
Enhancing Motor and Sensory Axon Regeneration after Peripheral Nerve Injury Using Bioluminescent Optogenetics.
Int J Mol Sci Volume: 23
12/16/2022 Authors: Ecanow A; Berglund K; Carrasco D; Isaacson R; English AW -
Oral Treatments With the TrkB Ligand Prodrug, R13, Promote Enhanced Axon Regeneration Following Peripheral Nerve Injury.
Front Cell Neurosci Volume: 16 Page(s): 857664
01/01/2022 Authors: English AW; Carrasco D; Hoffman D; Isaacson R; Kang SS; Khan S; Liu X; Ye K -
Bioluminescent Optogenetics: A Novel Experimental Therapy to Promote Axon Regeneration after Peripheral Nerve Injury.
Int J Mol Sci Volume: 22
07/05/2021 Authors: English AW; Berglund K; Carrasco D; Goebel K; Gross RE; Isaacson R; Mistretta OC; Wynans C -
Neuronal androgen receptor is required for activity dependent enhancement of peripheral nerve regeneration.
Dev Neurobiol Volume: 81 Page(s): 411 - 423
05/01/2021 Authors: Ward PJ; Davey RA; Zajac JD; English AW