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Profile

Hicham Drissi

  • Department of Orthopaedics
    Professor
  • hicham.drissi@emory.edu
Head shot of Hicham Drissi

Academic Appointment

  • Professor, Orthopaedics, Emory University
  • Vice Chair, Research, Orthopaedics, Emory University
  • Professor, Cell Biology, Emory University

Education

Degrees

  • PhD from Paris Descartes University

Research

Publications

  • Kartogenin Enhances Chondrogenic Differentiation of iPSC Derived MSCs (iMSCs) and Improves Outcomes in an Osteochondral Defect Model in Male Rats.
    J Orthop Res Volume: 43 Page(s): 870 - 880
    04/01/2025 Authors: Chihab S; Khan NM; Eng T; Doan T; Kaiser JM; Drissi H
  • Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc.
    bioRxiv
    03/27/2025 Authors: Zhang C; Diaz-Hernandez ME; Fukunaga T; Sreekala S; Yoon ST; Haglund L; Drissi H
  • Dimethyl Fumarate attenuates synovial inflammation, reduces nociception, and inhibits the development of post-traumatic osteoarthritis.
    Biomed Pharmacother Volume: 183 Page(s): 117865
    02/01/2025 Authors: Khan NM; Kaiser JM; Chihab S; Eng T; Drissi H
  • Enhanced osteogenic potential of iPSC-derived mesenchymal progenitor cells following genome editing of GWAS variants in the RUNX1 gene.
    Bone Res Volume: 12 Page(s): 70
    12/06/2024 Authors: Khan NM; Wilderman A; Kaiser JM; Kamalakar A; Goudy SL; Cotney J; Drissi H
  • Teaming up to overcome challenges toward translation of new therapeutics for osteoarthritis.
    J Orthop Res Volume: 42 Page(s): 2659 - 2672
    12/01/2024 Authors: Scanzello CR; Hasty KA; Chung CB; Griffin TM; Willet NJ; Krug H; Chu C-Q; Ewart D; Jerban S; Baker JF
  • Early signs of osteoarthritis in differing rat osteochondral defects.
    J Orthop Res Volume: 42 Page(s): 2461 - 2472
    11/01/2024 Authors: Chihab S; Eng T; Kaiser JM; Khan NM; Doan TN; Drissi H
  • Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects.

    10/14/2024 Authors: Kamalakar A; Tobin B; Kaimari S; Robinson MH; Toma AI; Cha T; Chihab S; Moriarity I; Gautam S; Bhattaram P
  • Single-cell transcriptome and crosstalk analysis reveals immune alterations and key pathways in the bone marrow of knee OA patients.
    iScience Volume: 27 Page(s): 110827
    09/20/2024 Authors: Chatterjee P; Stevens HY; Kippner LE; Bowles-Welch AC; Drissi H; Mautner K; Yeago C; Gibson G; Roy K
  • Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs.
    Cells Volume: 13
    09/04/2024 Authors: Diaz-Hernandez ME; Murakami K; Murata S; Khan NM; Shenoy SPV; Henke K; Yamada H; Drissi H
  • Delivery of A Jagged1-PEG-MAL hydrogel with Pediatric Human Bone Cells Regenerates Critically-Sized Craniofacial Bone Defects.
    bioRxiv
    06/20/2024 Authors: Kamalakar A; Tobin B; Kaimari S; Robinson MH; Toma AI; Cha T; Chihab S; Moriarity I; Gautam S; Bhattaram P
  • Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast-osteoblast communication and potential clinical implications.
    Elife Volume: 13
    04/09/2024 Authors: Daponte V; Henke K; Drissi H
  • IL-17RA Signaling in Prx1+ Mesenchymal Cells Influences Fracture Healing in Mice.
    Int J Mol Sci Volume: 25
    03/28/2024 Authors: Roberts JL; Kapfhamer D; Devarapalli V; Drissi H
  • Author Correction: Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial.
    Nat Med Volume: 30 Page(s): 905
    03/01/2024 Authors: Mautner K; Gottschalk M; Boden SD; Akard A; Bae WC; Black L; Boggess B; Chatterjee P; Chung CB; Easley KA
  • Differential efficacy of two small molecule PHLPP inhibitors to promote nucleus Pulposus cell health.
    JOR Spine Volume: 7 Page(s): e1306
    03/01/2024 Authors: Zhang C; Gordon MD; Joseph KM; Diaz-Hernandez ME; Drissi H; Illien-Jnger S
  • Cell-based versus corticosteroid injections for knee pain in osteoarthritis: a randomized phase 3 trial.
    Nat Med Volume: 29 Page(s): 3120 - 3126
    12/01/2023 Authors: Mautner K; Gottschalk M; Boden SD; Akard A; Bae WC; Black L; Boggess B; Chatterjee P; Chung CB; Easley KA
  • Systemic inflammatory and gut microbiota responses to fracture in young and middle-aged mice.
    Geroscience Volume: 45 Page(s): 3115 - 3129
    12/01/2023 Authors: Roberts JL; Chiedo B; Drissi H
  • Leveraging 3D Bioprinting and Photon-Counting Computed Tomography to Enable Noninvasive Quantitative Tracking of Multifunctional Tissue Engineered Constructs.
    Adv Healthc Mater Volume: 12 Page(s): e2302271
    12/01/2023 Authors: Gil CJ; Evans CJ; Li L; Allphin AJ; Tomov ML; Jin L; Vargas M; Hwang B; Wang J; Putaturo V
  • Redefining stem cells through their use in musculoskeletal tissue preservation, regeneration, and cancer metastases to bone.
    Bone Rep Volume: 19 Page(s): 101678
    12/01/2023 Authors: Drissi H; Taipaleenmki H; Jorgensen C
  • Efficient Differentiation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Mesenchymal Progenitors Into Adipocytes and Osteoblasts.
    Bio Protoc Volume: 13 Page(s): e4885
    11/20/2023 Authors: Diaz-Hernandez ME; Khan NM; Drissi H
  • Differentiation of Human Induced Pluripotent Stem Cells (iPSCs)-derived Mesenchymal Progenitors into Chondrocytes.
    Bio Protoc Volume: 13 Page(s): e4874
    11/05/2023 Authors: Khan NM; Diaz-Hernandez ME; Drissi H
  • MyD88 dimerization inhibitor ST2825 targets the aggressiveness of synovial fibroblasts in rheumatoid arthritis patients.
    Arthritis Res Ther Volume: 25 Page(s): 180
    09/25/2023 Authors: Ramirez-Perez S; Vekariya R; Gautam S; Reyes-Perez IV; Drissi H; Bhattaram P
  • Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel.
    Bioengineering (Basel) Volume: 10
    08/27/2023 Authors: Brackin RB; McColgan GE; Pucha SA; Kowalski MA; Drissi H; Doan TN; Patel JM
  • Sclerostin small-molecule inhibitors promote osteogenesis by activating canonical Wnt and BMP pathways.
    Elife Volume: 12
    08/10/2023 Authors: Sangadala S; Kim CH; Fernandes LM; Makkar P; Beck GR; Boden SD; Drissi H; Presciutti SM
  • Bifidobacterium longum supplementation improves age-related delays in fracture repair.
    Aging Cell Volume: 22 Page(s): e13786
    04/01/2023 Authors: Roberts JL; Golloshi M; Harding DB; Conduah M; Liu G; Drissi H
  • Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures.
    Elife Volume: 12
    01/30/2023 Authors: Khan NM; Diaz-Hernandez ME; Chihab S; Priyadarshani P; Bhattaram P; Mortensen LJ; Guzzo RM; Drissi H
  • pH-sensing G protein-coupled orphan receptor GPR68 is expressed in human cartilage and correlates with degradation of extracellular matrix during OA progression.
    PeerJ Volume: 11 Page(s): e16553
    01/01/2023 Authors: Khan NM; Diaz-Hernandez ME; Martin WN; Patel B; Chihab S; Drissi H
  • PHLPP1 deficiency protects against age-related intervertebral disc degeneration.
    JOR Spine Volume: 5 Page(s): e1224
    12/01/2022 Authors: Zhang C; Joseph KM; Khan NM; Diaz-Hernandez ME; Drissi H; Illien-Junger S
  • Cartilage-penetrating hyaluronic acid hydrogel preserves tissue content and reduces chondrocyte catabolism.
    J Tissue Eng Regen Med Volume: 16 Page(s): 1138 - 1148
    12/01/2022 Authors: Kowalski MA; Fernandes LM; Hammond KE; Labib S; Drissi H; Patel JM
  • Sexually Dimorphic Increases in Bone Mass Following Tissue-specific Overexpression of Runx1 in Osteoclast Precursors.
    Endocrinology Volume: 163
    09/01/2022 Authors: Daz-Hernndez ME; Kinter CW; Watson SR; Mella-Velazquez G; Kaiser J; Liu G; Khan NM; Roberts JL; Lorenzo J; Drissi H
  • AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells invivo.
    Genes Dis Volume: 9 Page(s): 1074 - 1085
    07/01/2022 Authors: Kim CH; Oliver C; Dar H; Drissi H; Presciutti SM
  • Insulin-Functionalized Bioactive Fiber Matrices with Bone Marrow-Derived Stem Cells in Rat Achilles Tendon Regeneration.
    ACS Appl Bio Mater Volume: 5 Page(s): 2851 - 2861
    06/20/2022 Authors: Ramos DM; Abdulmalik S; Arul MR; Sardashti N; Banasavadi-Siddegowda YK; Nukavarapu SP; Drissi H; Kumbar SG
  • HIGH-DIMENSIONALL MULTI-OMICS COMPARISON OF CELLS IN BONE MARROW REVEALED ALTERATIONS TO IMMUNE CELLS IN OSTEOARTHRITIS
    Volume: 24 Page(s): S46 - S46
    05/01/2022 Authors: Chatterjee P; Stevens H; Bowles-Welch AC; Kippner L; Marmon A; Drissi H; Gibson G; Yeago C; Roy K
  • NSAIDs Reduce Therapeutic Efficacy of Mesenchymal Stromal Cell Therapy in a Rodent Model of Posttraumatic Osteoarthritis.
    Am J Sports Med Volume: 50 Page(s): 1389 - 1398
    04/01/2022 Authors: Sok D; Raval S; McKinney J; Drissi H; Mason A; Mautner K; Kaiser JM; Willett NJ
  • Deletion of IL-17ra in osteoclast precursors increases bone mass by decreasing osteoclast precursor abundance.
    Bone Volume: 157 Page(s): 116310
    04/01/2022 Authors: Roberts JL; Mella-Velazquez G; Dar HY; Liu G; Drissi H
  • IL-17ra signaling represses Runx1 to promote osteoclastogenesis and bone resorption
    Volume: 37 Page(s): 300 - 300
    02/01/2022 Authors: Roberts J; Mella-Velazquez G; Dar H; Drissi H
  • Runx1 regulates osteoclast differentiation by modulation of redox signaling.
    Volume: 37 Page(s): 300 - 300
    02/01/2022 Authors: Diaz-Hernandez ME; Kinter CW; Mella G; Drissi H; Roberts JL; Khan NM
  • SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes.
    Front Immunol Volume: 13 Page(s): 789349
    01/01/2022 Authors: Jones K; Ramirez-Perez S; Niu S; Gangishetti U; Drissi H; Bhattaram P
  • miR-433-3p suppresses bone formation and mRNAs critical for osteoblast function in mice.
    J Bone Miner Res Volume: 36 Page(s): 1808 - 1822
    09/01/2021 Authors: Garcia J; Smith SS; Karki S; Drissi H; Hrdlicka HH; Youngstrom DW; Delany AM
  • Sexual Dimorphism in Differentiating Osteoclast Precursors Demonstrates Enhanced Inflammatory Pathway Activation in Female Cells.
    Volume: 36 Page(s): 1104 - 1116
    06/01/2021 Authors: Mun SH; Jastrzebski S; Kalinowski J; Zeng S; Oh B; Bae S; Eugenia G; Khan NM; Drissi H; Zhou P
  • Osteoinductive effect of soluble transforming growth factor beta receptor 3 on human osteoblast lineage.
    J Cell Biochem Volume: 122 Page(s): 538 - 548
    05/01/2021 Authors: Amanso AM; Kamalakar A; Bitarafan S; Abramowicz S; Drissi H; Barnett JV; Wood LB; Goudy SL
  • The temporal and spatial expression of sclerostin and Wnt signaling factors during the maturation of posterolateral lumbar spine fusions.
    JOR Spine Volume: 4 Page(s): e1100
    03/01/2021 Authors: Rodriguez-Feo J; Fernandes L; Patel A; Doan T; Boden SD; Drissi H; Presciutti SM
  • JAGGED1 stimulates cranial neural crest cell osteoblast commitment pathways and bone regeneration independent of canonical NOTCH signaling.
    Bone Volume: 143 Page(s): 115657
    02/01/2021 Authors: Kamalakar A; McKinney JM; Salinas Duron D; Amanso AM; Ballestas SA; Drissi H; Willett NJ; Bhattaram P; Garca AJ; Wood LB
  • Generation and Experimental Outcomes of Closed Femoral Fracture in Mice.
    Volume: 2221 Page(s): 205 - 222
    01/01/2021 Authors: Roberts JL; Kinter CW; Drissi H
  • Bifidobacterium adolescentis supplementation attenuates fracture-induced systemic sequelae.
    Biomed Pharmacother Volume: 132 Page(s): 110831
    12/01/2020 Authors: Roberts JL; Liu G; Darby TM; Fernandes LM; Diaz-Hernandez ME; Jones RM; Drissi H
  • Chronic exposure to TNF reprograms cell signaling pathways in fibroblast-like synoviocytes by establishing long-term inflammatory memory.
    Sci Rep Volume: 10 Page(s): 20297
    11/20/2020 Authors: Gangishetti U; Ramirez-Perez S; Jones K; Arif A; Drissi H; Bhattaram P
  • Metabolomic Associations with Serum Bone Turnover Markers.
    Nutrients Volume: 12
    10/16/2020 Authors: Bellissimo MP; Roberts JL; Jones DP; Liu KH; Taibl KR; Uppal K; Weitzmann MN; Pacifici R; Drissi H; Ziegler TR
  • Single-cell RNA-seq identifies unique transcriptional landscapes of human nucleus pulposus and annulus fibrosus cells.
    Sci Rep Volume: 10 Page(s): 15263
    09/17/2020 Authors: Fernandes LM; Khan NM; Trochez CM; Duan M; Diaz-Hernandez ME; Presciutti SM; Gibson G; Drissi H
  • Gain-of-function variants and overexpression of RUNX2 in patients with nonsyndromic midline craniosynostosis.
    Bone Volume: 137 Page(s): 115395
    08/01/2020 Authors: Cuellar A; Bala K; Di Pietro L; Barba M; Yagnik G; Liu JL; Stevens C; Hur DJ; Ingersoll RG; Justice CM
  • Comparative transcriptomic analysis identifies distinct molecular signatures and regulatory networks of chondroclasts and osteoclasts.
    Arthritis Res Ther Volume: 22 Page(s): 168
    07/10/2020 Authors: Khan NM; Clifton KB; Lorenzo J; Hansen MF; Drissi H
  • Network Analysis Identifies Gene Regulatory Network Indicating the Role of RUNX1 in Human Intervertebral Disc Degeneration.
    Genes (Basel) Volume: 11
    07/09/2020 Authors: Khan NM; Diaz-Hernandez ME; Presciutti SM; Drissi H
  • Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell-transcriptomics.
    J Cell Physiol Volume: 235 Page(s): 5241 - 5255
    06/01/2020 Authors: Diaz-Hernandez ME; Khan NM; Trochez CM; Yoon T; Maye P; Presciutti SM; Gibson G; Drissi H
  • Deletion of Runx1 in osteoclasts impairs murine fracture healing through progressive woven bone loss and delayed cartilage remodeling.
    J Orthop Res Volume: 38 Page(s): 1007 - 1015
    05/01/2020 Authors: Paglia DN; Diaz-Hernandez ME; Roberts JL; Kalinowski J; Lorenzo J; Drissi H
  • Advances and Promises of Nutritional Influences on Natural Bone Repair.
    J Orthop Res Volume: 38 Page(s): 695 - 707
    04/01/2020 Authors: Roberts JL; Drissi H
  • Deletion of Wnt5a in osteoclasts results in bone loss through decreased bone formation.
    Ann N Y Acad Sci Volume: 1463 Page(s): 45 - 59
    03/01/2020 Authors: Roberts JL; Liu G; Paglia DN; Kinter CW; Fernandes LM; Lorenzo J; Hansen MF; Arif A; Drissi H
  • American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies - Secondary Publication.
    J Orthop Res Volume: 38 Page(s): 485 - 502
    03/01/2020 Authors: O'Keefe RJ; Tuan RS; Lane NE; Awad HA; Barry F; Bunnell BA; Colnot C; Drake MT; Drissi H; Dyment NA
  • American Society for Bone and Mineral Research-Orthopaedic Research Society Joint Task Force Report on Cell-Based Therapies.
    J Bone Miner Res Volume: 35 Page(s): 3 - 17
    01/01/2020 Authors: O'Keefe RJ; Tuan RS; Lane NE; Awad HA; Barry F; Bunnell BA; Colnot C; Drake MT; Drissi H; Dyment NA
  • The Promises and Challenges of Stem Cells Use for Orthopedic Applications: A New and Exciting Era in Biological Treatments.
    Tech Orthop Volume: 34 Page(s): 223
    12/01/2019 Authors: Drissi H
  • Harnessing the Osteo-inductive Property of JAGGED1 as a Maxillary Bone Regenerative Intervention
    Volume: 34 Page(s): 221 - 221
    12/01/2019 Authors: Kamalakar A; Amanso A; Ballestas S; Willett N; Drissi H; Goudy S; Davis M
  • Harnessing the Osteo-inductive Property of JAGGED1 as a Maxillary Bone Regenerative Intervention
    Volume: 34 Page(s): 221 - 221
    12/01/2019 Authors: Kamalakar A; Amanso A; Ballestas S; Willett N; Drissi H; Goudy S; Davis M
  • Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism.
    Volume: 203 Page(s): 105 - 116
    07/01/2019 Authors: Jastrzebski S; Kalinowski J; Mun S; Shin B; Adapala NS; Jacome-Galarza CE; Mirza F; Aguila HL; Drissi H; Sanjay A
  • A non-canonical JAGGED1 signal to JAK2 mediates osteoblast commitment in cranial neural crest cells.
    Cell Signal Volume: 54 Page(s): 130 - 138
    02/01/2019 Authors: Kamalakar A; Oh MS; Stephenson YC; Ballestas-Naissir SA; Davis ME; Willett NJ; Drissi HM; Goudy SL
  • Articular cartilage protection in Ctsk-/- mice is associated with cellular and molecular changes in subchondral bone and cartilage matrix.
    J Cell Physiol Volume: 233 Page(s): 8666 - 8676
    11/01/2018 Authors: Soki FN; Yoshida R; Paglia DN; Duong LT; Hansen MF; Drissi H
  • Transcriptional Mechanisms of Secondary Fracture Healing.
    Curr Osteoporos Rep Volume: 16 Page(s): 146 - 154
    04/01/2018 Authors: Roberts JL; Paglia DN; Drissi H
  • A novel role for cathepsin K in periosteal osteoclast precursors during fracture repair.
    Ann N Y Acad Sci Volume: 1415 Page(s): 57 - 68
    03/01/2018 Authors: Walia B; Lingenheld E; Duong L; Sanjay A; Drissi H
  • Dried plum alleviates symptoms of inflammatory arthritis in TNF transgenic mice.
    J Nutr Biochem Volume: 52 Page(s): 54 - 61
    02/01/2018 Authors: Mirza F; Lorenzo J; Drissi H; Lee FY; Soung DY
  • A Role for Cathepsin K in the Periosteal Response to Bone Repair
    Volume: 32 Page(s): S349 - S350
    12/01/2017 Authors: Walia B; Lingenheld E; Duong L; Sanjay A; Drissi H
  • Overexpression of MiR-335-5p Promotes Bone Formation and Regeneration in Mice.
    J Bone Miner Res Volume: 32 Page(s): 2466 - 2475
    12/01/2017 Authors: Zhang L; Tang Y; Zhu X; Tu T; Sui L; Han Q; Yu L; Meng S; Zheng L; Valverde P
  • Calreticulin inhibits inflammation-induced osteoclastogenesis and bone resorption.
    J Orthop Res Volume: 35 Page(s): 2658 - 2666
    12/01/2017 Authors: Fischer CR; Mikami M; Minematsu H; Nizami S; Goo Lee H; Stamer D; Patel N; Yu Soung D; Back J-H; Song L
  • Sex differences in the estrogen-dependent regulation of temporomandibular joint remodeling in altered loading.
    Osteoarthritis Cartilage Volume: 25 Page(s): 533 - 543
    04/01/2017 Authors: Robinson JL; Cass K; Aronson R; Choi T; Xu M; Buttenbaum R; Drissi H; Lu HH; Chen J; Wadhwa S
  • Low-energy impact of human cartilage: predictors for microcracking the network of collagen.
    Osteoarthritis Cartilage Volume: 25 Page(s): 544 - 553
    04/01/2017 Authors: Kaleem B; Maier F; Drissi H; Pierce DM
  • Loss of Cbl-PI3K interaction modulates the periosteal response to fracture by enhancing osteogenic commitment and differentiation.
    Bone Volume: 95 Page(s): 124 - 135
    02/01/2017 Authors: Scanlon V; Walia B; Yu J; Hansen M; Drissi H; Maye P; Sanjay A
  • Regeneration of Articular Cartilage by Human ESC-Derived Mesenchymal Progenitors Treated Sequentially with BMP-2 and Wnt5a.
    Stem Cells Transl Med Volume: 6 Page(s): 40 - 50
    01/01/2017 Authors: Gibson JD; O'Sullivan MB; Alaee F; Paglia DN; Yoshida R; Guzzo RM; Drissi H
  • Cyclic loading of human articular cartilage: The transition from compaction to fatigue.
    J Mech Behav Biomed Mater Volume: 65 Page(s): 734 - 742
    01/01/2017 Authors: Kaplan JT; Neu CP; Drissi H; Emery NC; Pierce DM
  • Shear deformations of human articular cartilage: Certain mechanical anisotropies apparent at large but not small shear strains.
    J Mech Behav Biomed Mater Volume: 65 Page(s): 53 - 65
    01/01/2017 Authors: Maier F; Drissi H; Pierce DM
  • Runx1 Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or Phagocytic Cells in Both Males and Females.
    Endocrinology Volume: 157 Page(s): 3058 - 3069
    08/01/2016 Authors: Paglia DN; Yang X; Kalinowski J; Jastrzebski S; Drissi H; Lorenzo J
  • The Multifaceted Osteoclast; Far and Beyond Bone Resorption.
    J Cell Biochem Volume: 117 Page(s): 1753 - 1756
    08/01/2016 Authors: Drissi H; Sanjay A
  • HIF-1-Dependent IL-6 Activation in Articular Chondrocytes Initiating Synovitis in Femoral Head Ischemic Osteonecrosis.
    J Bone Joint Surg Am Volume: 98 Page(s): 1122 - 1131
    07/06/2016 Authors: Yamaguchi R; Kamiya N; Adapala NS; Drissi H; Kim HKW
  • PDGF-BB Delays Degeneration of the Intervertebral Discs in a Rabbit Preclinical Model.
    Spine (Phila Pa 1976) Volume: 41 Page(s): E449 - E458
    04/01/2016 Authors: Paglia DN; Singh H; Karukonda T; Drissi H; Moss IL
  • Aberrant expression of Twist1 in diseased articular cartilage and a potential role in the modulation of osteoarthritis severity.
    Genes Dis Volume: 3 Page(s): 88 - 99
    03/01/2016 Authors: Guzzo RM; Alaee F; Paglia D; Gibson JD; Spicer D; Drissi H
  • TIEG1 enhances Osterix expression and mediates its induction by TGF and BMP2 in osteoblasts.
    Biochem Biophys Res Commun Volume: 470 Page(s): 528 - 533
    02/12/2016 Authors: Subramaniam M; Pitel KS; Withers SG; Drissi H; Hawse JR
  • Evaluation of enzymatically crosslinked injectable glycol chitosan hydrogel.
    J Mater Chem B Volume: 3 Page(s): 5511 - 5522
    07/21/2015 Authors: Gohil SV; Brittain SB; Kan H-M; Drissi H; Rowe DW; Nair LS
  • The role of transduced bone marrow cells overexpressing BMP-2 in healing critical-sized defects in a mouse femur.
    Gene Ther Volume: 22 Page(s): 467 - 475
    06/01/2015 Authors: Pensak M; Hong S; Dukas A; Tinsley B; Drissi H; Tang A; Cote M; Sugiyama O; Lichtler A; Rowe D
  • Legg-Calv-Perthes disease produces chronic hip synovitis and elevation of interleukin-6 in the synovial fluid.
    J Bone Miner Res Volume: 30 Page(s): 1009 - 1013
    06/01/2015 Authors: Kamiya N; Yamaguchi R; Adapala NS; Chen E; Neal D; Jack O; Thoveson A; Gudmundsson P; Brabham C; Aruwajoye O
  • Relationship between oxidative stress and bone mass in obesity and effects of berry supplementation on bone remodeling in obese male mice: an exploratory study.
    J Med Food Volume: 18 Page(s): 476 - 482
    04/01/2015 Authors: Lee SG; Kim B; Soung DY; Vance T; Lee JS; Lee J-Y; Koo SI; Kim D-O; Drissi H; Chun OK
  • Surgical procedures and experimental outcomes of closed fractures in rodent models.
    Methods Mol Biol Volume: 1226 Page(s): 193 - 211
    01/01/2015 Authors: Drissi H; Paglia DN
  • Biodistribution of LV-TSTA transduced rat bone marrow cells used for "ex-vivo" regional gene therapy for bone repair.
    Curr Gene Ther Volume: 15 Page(s): 481 - 491
    01/01/2015 Authors: Alaee F; Bartholomae C; Sugiyama O; Virk MS; Drissi H; Wu Q; Schmidt M; Lieberman JR
  • Differentiation of Human Induced Pluripotent Stem Cells to Chondrocytes.
    Methods Mol Biol Volume: 1340 Page(s): 79 - 95
    01/01/2015 Authors: Guzzo RM; Drissi H
  • Derivation and Chondrogenic Commitment of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors.
    Methods Mol Biol Volume: 1340 Page(s): 65 - 78
    01/01/2015 Authors: Drissi H; Gibson JD; Guzzo RM; Xu R-H
  • Role of Cbl-PI3K Interaction during Skeletal Remodeling in a Murine Model of Bone Repair.
    PLoS One Volume: 10 Page(s): e0138194
    01/01/2015 Authors: Scanlon V; Soung DY; Adapala NS; Morgan E; Hansen MF; Drissi H; Sanjay A
  • Establishment of human cell type-specific iPS cells with enhanced chondrogenic potential.
    Stem Cell Rev Rep Volume: 10 Page(s): 820 - 829
    12/01/2014 Authors: Guzzo RM; Scanlon V; Sanjay A; Xu R-H; Drissi H
  • Constructing the toolbox: Patient-specific genetic factors of altered fracture healing.
    Genes Dis Volume: 1 Page(s): 140 - 148
    12/01/2014 Authors: Drissi H; Paglia DN; Alaee F; Yoshida R
  • Estrogen via estrogen receptor beta partially inhibits mandibular condylar cartilage growth.
    Osteoarthritis Cartilage Volume: 22 Page(s): 1861 - 1868
    11/01/2014 Authors: Chen J; Kamiya Y; Polur I; Xu M; Choi T; Kalajzic Z; Drissi H; Wadhwa S
  • PDGF-BB inhibits intervertebral disc cell apoptosis in vitro.
    J Orthop Res Volume: 32 Page(s): 1181 - 1188
    09/01/2014 Authors: Presciutti SM; Paglia DN; Karukonda T; Soung DY; Guzzo R; Drissi H; Moss IL
  • Increased fracture callus mineralization and strength in cathepsin K knockout mice.
    Bone Volume: 66 Page(s): 72 - 81
    09/01/2014 Authors: Gentile MA; Soung DY; Horrell C; Samadfam R; Drissi H; Duong LT
  • Effects of Wnt5a Haploinsufficiency on Bone Repair.
    J Orthop Trauma Volume: 28 Page(s): e191 - e197
    08/01/2014 Authors: Clifton KB; Paglia DN; Soung DY; Wolf JM; Moss IL; Drissi H
  • Altered hematopoietic stem cell and osteoclast precursor frequency in cathepsin K null mice.
    J Cell Biochem Volume: 115 Page(s): 1449 - 1457
    08/01/2014 Authors: Jacome-Galarza C; Soung DY; Adapala NS; Pickarski M; Sanjay A; Duong LT; Lorenzo JA; Drissi H
  • Biodistribution of LV-TSTA Transduced Rat Bone Marrow Cells Used for "Ex-Vivo" Regional Gene Therapy for Bone Repair
    Volume: 22 Page(s): S211 - S212
    05/01/2014 Authors: Alaee F; Bartholomae C; Sugiyama O; Virk M; Drissi H; Schmidt M; Lieberman JR
  • Runx1-mediated regulation of osteoclast differentiation and function.
    Mol Endocrinol Volume: 28 Page(s): 546 - 553
    04/01/2014 Authors: Soung DY; Kalinowski J; Baniwal SK; Jacome-Galarza CE; Frenkel B; Lorenzo J; Drissi H
  • Suicide gene approach using a dual-expression lentiviral vector to enhance the safety of ex vivo gene therapy for bone repair.
    Gene Ther Volume: 21 Page(s): 139 - 147
    02/01/2014 Authors: Alaee F; Sugiyama O; Virk MS; Tang H; Drissi H; Lichtler AC; Lieberman JR
  • Enhanced fracture healing following selective abrogation of Runx3 in the perisoteum.
    Volume: 29 Page(s): S157 - S158
    02/01/2014 Authors: Soung DY; Piccullio V; Sanjay A; Hansen M; Drissi H
  • Epigenetic regulation of miR-302 by JMJD1C inhibits neural differentiation of human embryonic stem cells.
    J Biol Chem Volume: 289 Page(s): 2384 - 2395
    01/24/2014 Authors: Wang J; Park JW; Drissi H; Wang X; Xu R-H
  • Functional role of Runx3 in the regulation of aggrecan expression during cartilage development.
    J Cell Physiol Volume: 228 Page(s): 2232 - 2242
    11/01/2013 Authors: Wigner NA; Soung DY; Einhorn TA; Drissi H; Gerstenfeld LC
  • Effects of pharmacological inhibition of cathepsin K on fracture repair in mice.
    Bone Volume: 55 Page(s): 248 - 255
    07/01/2013 Authors: Soung DY; Gentile MA; Duong LT; Drissi H
  • Increased mandibular condylar growth in mice with estrogen receptor beta deficiency.
    J Bone Miner Res Volume: 28 Page(s): 1127 - 1134
    05/01/2013 Authors: Kamiya Y; Chen J; Xu M; Utreja A; Choi T; Drissi H; Wadhwa S
  • Blueberry and blackcurrant consumption increases bone mineral density and content in high fat diet-induced obese male mice
    Volume: 27
    04/01/2013 Authors: Lee SG; Vance T; Soung DY; Kim B; Lee J; Koo SI; Drissi MH; Chun OK
  • Efficient differentiation of human iPSC-derived mesenchymal stem cells to chondroprogenitor cells.
    J Cell Biochem Volume: 114 Page(s): 480 - 490
    02/01/2013 Authors: Guzzo RM; Gibson J; Xu R-H; Lee FY; Drissi H
  • Control of cartilage maintenance and degeneration by Twist1 and Runx1 transcription factors
    Volume: 28
    02/01/2013 Authors: Guzzo R; Gibson J; Spicer D; Polkowski G; Drissi H
  • Cathepsin K null mice exhibit altered frequency of hematopoietic precursors in the bone marrow and in the periphery
    Volume: 28
    02/01/2013 Authors: Jacome C; Soung D; Pickarski M; Duong L; Lorenzo J; Drissi H
  • ALX4 gain-of-function mutations in nonsyndromic craniosynostosis.
    Hum Mutat Volume: 33 Page(s): 1626 - 1629
    12/01/2012 Authors: Yagnik G; Ghuman A; Kim S; Stevens CG; Kimonis V; Stoler J; Sanchez-Lara PA; Bernstein JA; Naydenov C; Drissi H
  • Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing.
    J Bone Miner Res Volume: 27 Page(s): 1585 - 1597
    07/01/2012 Authors: Soung DY; Talebian L; Matheny CJ; Guzzo R; Speck ME; Lieberman JR; Speck NA; Drissi H
  • Ski inhibits TGF-/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.
    J Cell Biochem Volume: 113 Page(s): 2156 - 2166
    06/01/2012 Authors: Kim K-O; Sampson ER; Maynard RD; O'Keefe RJ; Chen D; Drissi H; Rosier RN; Hilton MJ; Zuscik MJ
  • Roles of SATB2 in osteogenic differentiation and bone regeneration.
    Tissue Eng Part A Volume: 17 Page(s): 1767 - 1776
    07/01/2011 Authors: Zhang J; Tu Q; Grosschedl R; Kim MS; Griffin T; Drissi H; Yang P; Chen J
  • Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway.
    J Cell Physiol Volume: 226 Page(s): 1683 - 1693
    06/01/2011 Authors: Bradley EW; Drissi MH
  • "Same day" ex-vivo regional gene therapy: a novel strategy to enhance bone repair.
    Mol Ther Volume: 19 Page(s): 960 - 968
    05/01/2011 Authors: Virk MS; Sugiyama O; Park SH; Gambhir SS; Adams DJ; Drissi H; Lieberman JR
  • Persistent expression of Twist1 in chondrocytes causes growth plate abnormalities and dwarfism in mice.
    Int J Dev Biol Volume: 55 Page(s): 641 - 647
    01/01/2011 Authors: Guzzo RM; Andreeva V; Spicer DB; Drissi MH
  • Integration of phosphatidylinositol 3-kinase, Akt kinase, and Smad signaling pathway in BMP-2-induced osterix expression.
    Calcif Tissue Int Volume: 87 Page(s): 533 - 540
    12/01/2010 Authors: Mandal CC; Drissi H; Choudhury GG; Ghosh-Choudhury N
  • WNT5A regulates chondrocyte differentiation through differential use of the CaN/NFAT and IKK/NF-kappaB pathways.
    Mol Endocrinol Volume: 24 Page(s): 1581 - 1593
    08/01/2010 Authors: Bradley EW; Drissi MH
  • Rapid isolation of human stem cells (connective tissue progenitor cells) from the proximal humerus during arthroscopic rotator cuff surgery.
    Am J Sports Med Volume: 38 Page(s): 1438 - 1447
    07/01/2010 Authors: Mazzocca AD; McCarthy MBR; Chowaniec DM; Cote MP; Arciero RA; Drissi H
  • Parathyroid hormone induction of cyclooxygenase-2 in murine osteoblasts: role of the calcium-calcineurin-NFAT pathway.
    J Bone Miner Res Volume: 25 Page(s): 819 - 829
    04/01/2010 Authors: Huang H; Chikazu D; Voznesensky OS; Herschman HR; Kream BE; Drissi H; Pilbeam CC
  • Analysis of microarchitectural changes in a mouse temporomandibular joint osteoarthritis model.
    Arch Oral Biol Volume: 54 Page(s): 1091 - 1098
    12/01/2009 Authors: Chen J; Gupta T; Barasz JA; Kalajzic Z; Yeh W-C; Drissi H; Hand AR; Wadhwa S
  • Titanium particles stimulate COX-2 expression in synovial fibroblasts through an oxidative stress-induced, calpain-dependent, NF-kappaB pathway.
    Am J Physiol Cell Physiol Volume: 297 Page(s): C310 - C320
    08/01/2009 Authors: Wei X; Zhang X; Flick LM; Drissi H; Schwarz EM; O'Keefe RJ
  • Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation.
    J Orthop Res Volume: 27 Page(s): 785 - 792
    06/01/2009 Authors: Clark CA; Li T-F; Kim K-O; Drissi H; Zuscik MJ; Zhang X; O'Keefe RJ
  • Reduced COX-2 expression in aged mice is associated with impaired fracture healing.
    J Bone Miner Res Volume: 24 Page(s): 251 - 264
    02/01/2009 Authors: Naik AA; Xie C; Zuscik MJ; Kingsley P; Schwarz EM; Awad H; Guldberg R; Drissi H; Puzas JE; Boyce B
  • Effect of lamin A/C knockdown on osteoblast differentiation and function.
    J Bone Miner Res Volume: 24 Page(s): 283 - 293
    02/01/2009 Authors: Akter R; Rivas D; Geneau G; Drissi H; Duque G
  • Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice.
    J Biol Chem Volume: 284 Page(s): 3170 - 3182
    01/30/2009 Authors: Xiao L; Liu P; Li X; Doetschman T; Coffin JD; Drissi H; Hurley MM
  • Antitumoral activity and osteogenic potential of mesenchymal stem cells expressing the urokinase-type plasminogen antagonist amino-terminal fragment in a murine model of osteolytic tumor.
    Stem Cells Volume: 26 Page(s): 2981 - 2990
    11/01/2008 Authors: Fritz V; Nol D; Bouquet C; Opolon P; Voide R; Apparailly F; Louis-Plence P; Bouffi C; Drissi H; Xie C
  • Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.
    Arthritis Rheum Volume: 58 Page(s): 3132 - 3144
    10/01/2008 Authors: Wu Q; Kim K-O; Sampson ER; Chen D; Awad H; O'Brien T; Puzas JE; Drissi H; Schwarz EM; O'Keefe RJ
  • Teriparatide (1-34 human PTH) regulation of osterix during fracture repair.
    J Cell Biochem Volume: 105 Page(s): 219 - 226
    09/01/2008 Authors: Kaback LA; Soung DY; Naik A; Geneau G; Schwarz EM; Rosier RN; O'Keefe RJ; Drissi H
  • PTH Induces COX-2 in MC3T3-E1 Osteoblasts via cAMP-PKA and Calcium-Calcineurin Pathways
    Volume: 23 Page(s): S140 - S140
    09/01/2008 Authors: Huang H; Chikazu D; Voznesensky O; Dodge-Kafka K; Drissi H; Pilbeam C
  • TIEG: A Key Regulator of Runx2 and Osterix Gene Expression and Osteoblast Differentiation.
    Volume: 23 Page(s): S386 - S386
    09/01/2008 Authors: Hawse JR; Subramaniam N; Monroe DG; Syed FA; Iwaniec UT; Oursler MJ; Lian JB; Stein GS; van Wijnen AJ; Drissi H
  • Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.
    Oncogene Volume: 27 Page(s): 3605 - 3614
    06/05/2008 Authors: Eliseev RA; Dong Y-F; Sampson E; Zuscik MJ; Schwarz EM; O'Keefe RJ; Rosier RN; Drissi MH
  • Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2.
    J Bone Miner Res Volume: 23 Page(s): 314 - 325
    03/01/2008 Authors: Usui M; Xing L; Drissi H; Zuscik M; O'Keefe R; Chen D; Boyce BF
  • Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery.
    Mol Ther Volume: 16 Page(s): 466 - 473
    03/01/2008 Authors: Basile P; Dadali T; Jacobson J; Hasslund S; Ulrich-Vinther M; Sballe K; Nishio Y; Drissi MH; Langstein HN; Mitten DJ
  • Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity.
    J Orthop Res Volume: 26 Page(s): 96 - 105
    01/01/2008 Authors: Li D; Gromov K; Sballe K; Puzas JE; O'Keefe RJ; Awad H; Drissi H; Schwarz EM
  • Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification.
    J Cell Physiol Volume: 214 Page(s): 173 - 182
    01/01/2008 Authors: Kaback LA; Soung DY; Naik A; Smith N; Schwarz EM; O'Keefe RJ; Drissi H
  • Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner.
    Mol Endocrinol Volume: 21 Page(s): 2805 - 2820
    11/01/2007 Authors: Dong Y-F; Soung DY; Chang Y; Enomoto-Iwamoto M; Paris M; O'Keefe RJ; Schwarz EM; Drissi H
  • Mechanisms of osterix control of endochondral ossification
    Volume: 22 Page(s): S386 - S386
    09/01/2007 Authors: Soung DY; Kaback LA; Naik A; Smith N; Schwarz EM; O'Keefe RJ; Drissi H
  • Osteoblastic master regulator osterix mediates the feedback regulation of BMP-2 auto-expression via PI 3 kinase/Akt signaling
    Volume: 22 Page(s): S238 - S239
    09/01/2007 Authors: Mandal CC; Ghosh-Choudhury G; Drissi H; Ghosh-Choudhury N
  • Osterix mediates mesenchymal progenitor cell differentiation into osteoblasts downstream of PTH during bone repair
    Volume: 22 Page(s): S91 - S91
    09/01/2007 Authors: Kaback LA; Jiang Y; Naik A; Hock C; Schwarz EM; Bukata S; O'Keefe RJ; Drissi H
  • Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations.
    Environ Health Perspect Volume: 115 Page(s): 1276 - 1282
    09/01/2007 Authors: Zuscik MJ; Ma L; Buckley T; Puzas JE; Drissi H; Schwarz EM; O'Keefe RJ
  • SiRNA specific knockdown of lamin A/C inhibits osteogenic differentiation of human mesenchymal stem cells.
    Volume: 22 Page(s): S142 - S142
    09/01/2007 Authors: Akter R; Rivas D; Dong Y; Drissi H; Duque G
  • BMP-2-inducible osterix increases osteoblastic CSF-1 and RANKL/OPG ratio to induce osteoclast maturation
    Volume: 22 Page(s): S153 - S153
    09/01/2007 Authors: Mandall CC; Ghosh-Choudhury G; Drissi H; Ghosh-Choudhury N
  • Twist1 stage-specifically regulates chondrocyte differentiation downstream of TGF-beta and writ signaling
    Volume: 22 Page(s): S158 - S158
    09/01/2007 Authors: Dong Y; Chang Y; Soung DY; O'Keefe R; Schwarz E; Drissi H
  • Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.
    J Bone Miner Res Volume: 22 Page(s): 1260 - 1270
    08/01/2007 Authors: Soung DY; Dong Y; Wang Y; Zuscik MJ; Schwarz EM; O'Keefe RJ; Drissi H
  • Environmental agents affect skeletal growth and development.
    Birth Defects Res C Embryo Today Volume: 81 Page(s): 41 - 50
    03/01/2007 Authors: Holz JD; Sheu T-J; Drissi H; Matsuzawa M; Zuscik MJ; Puzas JE
  • Runx3/Cbfa3 regulates chondrogenesis and chondrocyte maturation.
    Volume: 21 Page(s): S341 - S341
    09/01/2006 Authors: Soung DY; Wang Y; Martinez A; Dong Y; Schwarz EM; O'Keefe RJ; Drissi H
  • Ski inhibits TGF-beta signaling and accelerates chondrocyte maturation via recruitment of HDAC to Smad2 and Smad3-containing transcriptional complexes.
    Volume: 21 Page(s): S337 - S337
    09/01/2006 Authors: Kim K; Schwarz EM; Drissi H; O'Keefe RJ; Puzas JE; Zuscik MJ; Rosier RN
  • TGF-beta activates cyclin D1 expression through a Smad3/beta-catenin-dependent mechanism in chondrocytes.
    Volume: 21 Page(s): S91 - S91
    09/01/2006 Authors: Li T; Chen M; Wu Q; Sheu T; Drissi H; Zuscik M; Chen D; O'Keefe RJ
  • Stage-specific effects of TGF-beta on Wnt signaling in chick chondrocytes.
    Volume: 21 Page(s): S91 - S91
    09/01/2006 Authors: Dong Y; Soung Q; Chen D; Schwarz EM; O'Keefe RJ; Drissi H
  • Cell cycle proteins cyclin D1-Cdk4 regulate Runx2 phosphorylation, ubiquitination and proteasome degradation.
    Volume: 21 Page(s): S41 - S41
    09/01/2006 Authors: Shen R; Wang X; Drissi H; O'Keefe RJ; Chen D
  • Anti-catabolic therapy exacerbates osteomyelitis without altering humoral immunity.
    Volume: 21 Page(s): S37 - S37
    09/01/2006 Authors: Li D; Gromov K; Awad H; O'Keefe RJ; Drissi H; Schwarz EM
  • Chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2.
    Volume: 21 Page(s): S12 - S12
    09/01/2006 Authors: Usui M; Chen D; Drissi H; Xing L; Boyce BF
  • Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.
    J Biol Chem Volume: 281 Page(s): 21296 - 21304
    07/28/2006 Authors: Li T-F; Chen D; Wu Q; Chen M; Sheu T-J; Schwarz EM; Drissi H; Zuscik M; O'Keefe RJ
  • Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.
    J Cell Physiol Volume: 208 Page(s): 77 - 86
    07/01/2006 Authors: Dong Y-F; Soung DY; Schwarz EM; O'Keefe RJ; Drissi H
  • Cyclin D1-cdk4 induce runx2 ubiquitination and degradation.
    J Biol Chem Volume: 281 Page(s): 16347 - 16353
    06/16/2006 Authors: Shen R; Wang X; Drissi H; Liu F; O'Keefe RJ; Chen D
  • Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene.
    Gene Volume: 372 Page(s): 62 - 70
    05/10/2006 Authors: Nishio Y; Dong Y; Paris M; O'Keefe RJ; Schwarz EM; Drissi H
  • COX-2 has a critical role during incorporation of structural bone allografts.
    Volume: 1068 Page(s): 532 - 542
    04/01/2006 Authors: O'Keefe RJ; Tiyapatanaputi P; Xie C; Li TF; Clark C; Zuscik MJ; Chen D; Drissi H; Schwarz E; Zhang X
  • Autoimmunity and bone.
    Volume: 1068 Page(s): 275 - 283
    04/01/2006 Authors: Schwarz EM; Looney RJ; Drissi MH; O'Keefe RJ; Boyce BF; Xing L; Ritchlin CT
  • Safety and efficacy of ultraviolet-a light-activated gene transduction for gene therapy of articular cartilage defects.
    J Bone Joint Surg Am Volume: 88 Page(s): 753 - 761
    04/01/2006 Authors: Maloney MD; Goater JJ; Parsons R; Ito H; O'Keefe RJ; Rubery PT; Drissi MH; Schwarz EM
  • Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.
    Exp Cell Res Volume: 312 Page(s): 40 - 50
    01/01/2006 Authors: Eliseev RA; Schwarz EM; Zuscik MJ; O'Keefe RJ; Drissi H; Rosier RN
  • Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.
    J Bone Miner Res Volume: 21 Page(s): 4 - 16
    01/01/2006 Authors: Li T-F; Darowish M; Zuscik MJ; Chen D; Schwarz EM; Rosier RN; Drissi H; O'Keefe RJ
  • Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.
    J Cell Biochem Volume: 96 Page(s): 1262 - 1273
    12/15/2005 Authors: Eliseev RA; Zuscik MJ; Schwarz EM; O'Keefe RJ; Drissi H; Rosier RN
  • Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis.
    J Bone Miner Res Volume: 20 Page(s): 1624 - 1636
    09/01/2005 Authors: Wang Y; Belflower RM; Dong Y-F; Schwarz EM; O'Keefe RJ; Drissi H
  • PTHrP induces Smurf2 and inhibits TGF-beta signaling in growth plate chondrocytes.
    Volume: 20 Page(s): S429 - S429
    09/01/2005 Authors: Herceg M; Mulcahey M; Kim K; Wu Q; Schwarz EM; Puzas JE; O'Keefe RJ; Drissi H; Zuscik MJ; Rosier RN
  • Titanium particles induce COX-2 through a NFkB dependent pathway in fibroblast-like synoviocytes.
    Volume: 20 Page(s): S356 - S356
    09/01/2005 Authors: Wei X; Drissi H; Zhang X; Zuscik MJ; Schwarz EM; O'Keefe RJ
  • Runx2-mediated transcriptional regulation of osterix in chondrocytes.
    Volume: 20 Page(s): S354 - S354
    09/01/2005 Authors: Nishio Y; Wang Y; Paris M; Schwarz EM; O'keefe RJ; Drissi H
  • Autoimmune IFN-Alpha irreversibly biases myelopoiesis towards dendritic cells and depletes osteoclast precursors: A central mechanism for non-erosive inflammatory arthritis.
    Volume: 20 Page(s): S303 - S303
    09/01/2005 Authors: Ma L; Awad H; Ritchlin C; O'Keefe RJ; Drissi H; Mathian A; Banchereau J; Schwarz FM
  • Dlx2 stimulates the murine chondrocyte maturation in vitro and in vivo.
    Volume: 20 Page(s): S40 - S40
    09/01/2005 Authors: Zhang Y; Zuscik M; Chen D; Rosier R; Schwarz E; Drissi H; O'Keefe R
  • Beta-catenin promotes growth plate chondrocyte differentiation and maturation.
    Volume: 20 Page(s): S29 - S29
    09/01/2005 Authors: Chen M; Yan Y; Dong Y; Drissi H; Chen D; O'Keefe RJ
  • Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta.
    J Cell Biochem Volume: 95 Page(s): 1057 - 1068
    08/01/2005 Authors: Dong Y; Drissi H; Chen M; Chen D; Zuscik MJ; Schwarz EM; O'Keefe RJ
  • Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles.
    J Bone Miner Res Volume: 20 Page(s): 1136 - 1148
    07/01/2005 Authors: Wei X; Zhang X; Zuscik MJ; Drissi MH; Schwarz EM; O'Keefe RJ
  • Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis.
    Mol Aspects Med Volume: 26 Page(s): 169 - 179
    06/01/2005 Authors: Drissi H; Zuscik M; Rosier R; O'Keefe R
  • Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development.
    J Cell Physiol Volume: 203 Page(s): 133 - 143
    04/01/2005 Authors: Smith N; Dong Y; Lian JB; Pratap J; Kingsley PD; van Wijnen AJ; Stein JL; Schwarz EM; O'Keefe RJ; Stein GS
  • Differential regulation of EP receptor isoforms during chondrogenesis and chondrocyte maturation.
    Biochem Biophys Res Commun Volume: 328 Page(s): 764 - 776
    03/18/2005 Authors: Clark CA; Schwarz EM; Zhang X; Ziran NM; Drissi H; O'Keefe RJ; Zuscik MJ
  • TNF-alpha expression is transcriptionally regulated by RANK ligand.
    J Cell Physiol Volume: 202 Page(s): 371 - 378
    02/01/2005 Authors: Zou W; Amcheslavsky A; Takeshita S; Drissi H; Bar-Shavit Z
  • PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.
    Exp Cell Res Volume: 300 Page(s): 159 - 169
    10/15/2004 Authors: Li T-F; Zuscik MJ; Ionescu AM; Zhang X; Rosier RN; Schwarz EM; Drissi H; O'Keefe RJ
  • Negative regulation of TGF-beta signaling by Smurf2 in growth plate chondrocytes
    Volume: 19 Page(s): S351 - S351
    10/01/2004 Authors: Mulcahey MK; Pirri M; Dong Y; Wu Q; Schwarz EM; Puzas JE; O'Keefe RJ; Drissi H; Rosier RN; Zuscik MJ
  • Cartilage-speciric over-expression of Smurf2 induces an osteoarthritic phenotype in mice.
    Volume: 19 Page(s): S11 - S11
    10/01/2004 Authors: Wu Q; Zuscik MJ; Schwarz EM; Mulcahey MK; O'Brien T; Drissi H; Puzas JE; O'Keefe RJ; Rosier RN
  • Smad3 deficient chondrocytes have accelerated differentiation and enhanced BMP signaling
    Volume: 19 Page(s): S47 - S47
    10/01/2004 Authors: Li T; Zuscik MJ; Chen D; Schwarz EM; Rosier RN; Drissi H; O'Keefe RJ
  • Runx1/Cbfa2 induces early stages of chondrogenesis in mouse limb bud cells
    Volume: 19 Page(s): S63 - S63
    10/01/2004 Authors: Belflower RM; Wang Y; Dong Y; Puzas JE; Schwarz EM; O'Keefe RJ; Drissi H
  • Specific domains of TRAP control bone formation at sites of remodeling.
    Volume: 19 Page(s): S141 - S141
    10/01/2004 Authors: Matsuzaw M; Sheu TJ; O'Keefe RJ; Rosier RN; Schwarz EM; Zuscik MJ; Drissi H; Puzas JE
  • Synergistic catabolic effects of TNF alpha and RANKL in articular chondrocytes
    Volume: 19 Page(s): S357 - S357
    10/01/2004 Authors: Ma L; Li P; Paschalis EP; Boskey AL; O'Keefe RJ; Schwarz EM; Drissi H
  • Wnt expression induces chondrocyte maturation through beta-catenin-mediated signaling: Modulation by TGF-beta.
    Volume: 19 Page(s): S350 - S350
    10/01/2004 Authors: Dong Y; Chen M; Zuscik MJ; Chen D; Schwarz EM; Rosier RN; Drissi H; O'Keefe RJ
  • Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.
    Exp Cell Res Volume: 299 Page(s): 128 - 136
    09/10/2004 Authors: Li T-F; Dong Y; Ionescu AM; Rosier RN; Zuscik MJ; Schwarz EM; O'Keefe RJ; Drissi H
  • Transforming growth factor-beta1 induced alteration of skeletal morphogenesis in vivo.
    J Orthop Res Volume: 22 Page(s): 687 - 696
    07/01/2004 Authors: Ferguson CM; Schwarz EM; Puzas JE; Zuscik MJ; Drissi H; O'Keefe RJ
  • 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes.
    J Cell Biochem Volume: 92 Page(s): 316 - 331
    05/15/2004 Authors: Zuscik MJ; Baden JF; Wu Q; Sheu TJ; Schwarz EM; Drissi H; O'Keefe RJ; Puzas JE; Rosier RN
  • Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.
    Bone Volume: 34 Page(s): 809 - 817
    05/01/2004 Authors: Zhang X; Ziran N; Goater JJ; Schwarz EM; Puzas JE; Rosier RN; Zuscik M; Drissi H; O'Keefe RJ
  • CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter.
    J Cell Physiol Volume: 198 Page(s): 428 - 440
    03/01/2004 Authors: Ionescu AM; Drissi H; Schwarz EM; Kato M; Puzas JE; McCance DJ; Rosier RN; Zuscik MJ; O'Keefe RJ
  • Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.
    J Cell Biochem Volume: 90 Page(s): 1287 - 1298
    12/15/2003 Authors: Drissi MH; Li X; Sheu TJ; Zuscik MJ; Schwarz EM; Puzas JE; Rosier RN; O'Keefe RJ
  • A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis.
    Calcif Tissue Int Volume: 73 Page(s): 584 - 593
    12/01/2003 Authors: Huang W; Drissi MH; O'Keefe RJ; Schwarz EM
  • Smad6 is induced by BMP-2 and modulates chondrocyte differentiation.
    J Orthop Res Volume: 21 Page(s): 908 - 913
    09/01/2003 Authors: Li X; Ionescu AM; Schwarz EM; Zhang X; Drissi H; Puzas JE; Rosier RN; Zuscik MJ; O'Keefe RJ
  • TNF-alpha expression is transcriptionally regulated by RANK ligand.
    Volume: 18 Page(s): S231 - S231
    09/01/2003 Authors: Zou W; Drissi H; Bar-Shavit Z
  • Smurf2-mediated loss of TGF-beta signaling stimulates articular chondrocyte maturation
    Volume: 18 Page(s): S7 - S7
    09/01/2003 Authors: Wu Q; Zuscik MJ; Baden JF; Schwarz EM; Drissi H; O'Keefe RJ; Puzas JE; Rosier RN
  • The aryl hydrocarbon receptor: What is its role in the skeleton?
    Volume: 18 Page(s): S222 - S223
    09/01/2003 Authors: Puzas JE; Ryan E; Drissi H; O'Keefe RJ; Zuscik MJ; Rosier RN; Schwarz EM; Gasiewicz TA
  • Runx1/Cbfa2 contributes to proper endochondral ossification during fracture healing.
    Volume: 18 Page(s): S192 - S192
    09/01/2003 Authors: McDougall KE; Belflower RM; Dong Y; van Wijnen AJ; Stein JL; Lian JB; Stein GS; Schwarz EM; O'Keefe RJ; Drissi H
  • Runx1/AML1 hematopoietic transcription factor contributes to skeletal development in vivo.
    J Cell Physiol Volume: 196 Page(s): 301 - 311
    08/01/2003 Authors: Lian JB; Balint E; Javed A; Drissi H; Vitti R; Quinlan EJ; Zhang L; Van Wijnen AJ; Stein JL; Speck N
  • ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation.
    Exp Cell Res Volume: 288 Page(s): 198 - 207
    08/01/2003 Authors: Ionescu AM; Schwarz EM; Zuscik MJ; Drissi H; Puzas JE; Rosier RN; O'Keefe RJ
  • Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5.
    Endocrinology Volume: 144 Page(s): 2514 - 2523
    06/01/2003 Authors: Li X; Schwarz EM; Zuscik MJ; Rosier RN; Ionescu AM; Puzas JE; Drissi H; Sheu T-J; O'Keefe RJ
  • Phenotype discovery by gene expression profiling: mapping of biological processes linked to BMP-2-mediated osteoblast differentiation.
    J Cell Biochem Volume: 89 Page(s): 401 - 426
    05/15/2003 Authors: Balint E; Lapointe D; Drissi H; van der Meijden C; Young DW; van Wijnen AJ; Stein JL; Stein GS; Lian JB
  • Runx2/Cbfa1 functions: diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions.
    Connect Tissue Res Volume: 44 Suppl 1 Page(s): 141 - 148
    01/01/2003 Authors: Lian JB; Stein JL; Stein GS; van Wijnen AJ; Montecino M; Javed A; Gutierrez S; Shen J; Zaidi SK; Drissi H
  • Transcription factors RUNX1/AML1 and RUNX2/Cbfa1 dynamically associate with stationary subnuclear domains.
    J Cell Sci Volume: 115 Page(s): 4167 - 4176
    11/01/2002 Authors: Harrington KS; Javed A; Drissi H; McNeil S; Lian JB; Stein JL; Van Wijnen AJ; Wang Y-L; Stein GS
  • Runx1(Cbfa2/AML1) is expressed in tissues supporting osteogenesis and temporally regulated during chondrocyte and osteoblast differentiation.
    Volume: 17 Page(s): S151 - S151
    09/01/2002 Authors: Balint E; Javed A; Drissi H; Vitti R; Quinlan E; Zhang L; North T; van Wijnen AJ; Stein JL; Stein GS
  • Gene expression profiling analysis of BMP-2 induced commitment towards the osteoblast lineage.
    Volume: 17 Page(s): S337 - S337
    09/01/2002 Authors: Balint E; Lapointe DS; Drissi H; van Wijnen J; Stein JL; Lian JB; Stein GS
  • Runx factors are expressed in the osteoclast and regulated during osteoclast differentiation.
    Volume: 17 Page(s): S452 - S452
    09/01/2002 Authors: Bar-Shavit Z; Drissi H; Javed A; Ribadeneyra J; van Wijnen AJ; Stein JL; Lian JB; Stein GS
  • Activation of the bone-related Runx2/Cbfa1 promoter in mesenchymal condensations and developing chondrocytes of the axial skeleton.
    Mech Dev Volume: 114 Page(s): 167 - 170
    06/01/2002 Authors: Lengner CJ; Drissi H; Choi J-Y; van Wijnen AJ; Stein JL; Stein GS; Lian JB
  • 1,25-(OH)2-vitamin D3 suppresses the bone-related Runx2/Cbfa1 gene promoter.
    Exp Cell Res Volume: 274 Page(s): 323 - 333
    04/01/2002 Authors: Drissi H; Pouliot A; Koolloos C; Stein JL; Lian JB; Stein GS; van Wijnen AJ
  • Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha.
    J Biol Chem Volume: 277 Page(s): 2695 - 2701
    01/25/2002 Authors: Gilbert L; He X; Farmer P; Rubin J; Drissi H; van Wijnen AJ; Lian JB; Stein GS; Nanes MS
  • Identification of novel protein/DNA interactions within the promoter of the bone-related transcription factor Runx2/Cbfa1.
    J Cell Biochem Volume: 86 Page(s): 403 - 412
    01/01/2002 Authors: Drissi H; Pouliot A; Stein JL; van Wijnen AJ; Stein GS; Lian JB
  • The osteoblast differentiation factor RUNX2/Cbfa1 is suppressed by tumor necrosis factor-alpha.
    JOURNAL OF BONE AND MINERAL RESEARCH Volume: 16 Page(s): S204 - S204
    09/01/2001 Authors: Gilbert LC; He X; Rubin J; Drissi H; van Wijnen AJ; Lian JB; Stein GS; Nanes MS
  • Developmental utilization of distinct promoters regulating the type I and type II isoforms of the bone Runx2/Cbfa1 transcription factor.
    Volume: 16 Page(s): S205 - S205
    09/01/2001 Authors: Drissi H; Javed A; Balint E; Banerjee C; Adamidou F; Van Wijnen AJ; Stein JL; Stein GS; Lian JB
  • Identification of novel protein/DNA interactions within the proximal promoter of the bone-related transcription factor Runx2/Cbfa1.
    Volume: 16 Page(s): S205 - S205
    09/01/2001 Authors: Drissi H; Pouliot A; Stein JL; Lian JB; Stein GS; Van Wijnen AJ
  • The bone related Runx-2/Cbfa-1 promoter mediates restricted expression in mesenchymal condensations and chondrocytes.
    Volume: 16 Page(s): S366 - S366
    09/01/2001 Authors: Lengner CJ; Drissi H; Choi J; van Wijnen AJ; Stein JL; Stein GS; Lian JB
  • Trafficking of Runx1/Cbfa2 and Runx2/Cbfa1 in living cells defines a dynamic subnuclear domain.
    Volume: 16 Page(s): S488 - S488
    09/01/2001 Authors: Harrington KS; Javed A; Zaidi SK; Drissi H; van Wijnen AJ; Lian JB; Stein GS; Stein JL
  • Smad-Runx interactions during chondrocyte maturation.
    J Bone Joint Surg Am Volume: 83-A Suppl 1 Page(s): S15 - S22
    01/01/2001 Authors: Leboy P; Grasso-Knight G; D'Angelo M; Volk SW; Lian JV; Drissi H; Stein GS; Adams SL
  • Vitamin D dependent suppression of the bone-related RUNX2/CBFA1 gene promoter.
    Volume: 15 Page(s): S181 - S181
    09/01/2000 Authors: Drissi H; Koolloos C; Pouliot A; Stein JL; Stein GS; Lian JB; van Wijnen AJ
  • Transcriptional autoregulation of the bone related CBFA1/RUNX2 gene.
    J Cell Physiol Volume: 184 Page(s): 341 - 350
    09/01/2000 Authors: Drissi H; Luc Q; Shakoori R; Chuva De Sousa Lopes S; Choi JY; Terry A; Hu M; Jones S; Neil JC; Lian JB
  • Skeletal unloading induces biphasic changes in insulin-like growth factor-I mRNA levels and osteoblast activity.
    Exp Cell Res Volume: 251 Page(s): 275 - 284
    09/15/1999 Authors: Drissi H; Lomri A; Lasmoles F; Holy X; Zerath E; Marie PJ
  • Autoregulation of the CBFA1 gene by bone specific isoforms of the runt homology transcription factor CBFA1/AML3/PEBP2 alpha A in cells committed to the osteoblast lineage.
    Volume: 14 Page(s): S154 - S154
    09/01/1999 Authors: Drissi H; Shakoori R; Hu M; Neil JC; Stein JL; Lian JB; Stein GS; van Wijnen AJ
  • The bone-specific promoter of the CBFA1 gene is activated by the AP-1 transcription factor in osseous cells.
    Volume: 14 Page(s): S155 - S155
    09/01/1999 Authors: Drissi H; Lopes SCD; Jones S; Terry A; Neil JC; Lian JB; Stein JL; van Wijnen AJ; Stein GS
  • The cell cycle regulator p27kip1 contributes to growth and differentiation of osteoblasts.
    Cancer Res Volume: 59 Page(s): 3705 - 3711
    08/01/1999 Authors: Drissi H; Hushka D; Aslam F; Nguyen Q; Buffone E; Koff A; van Wijnen A; Lian JB; Stein JL; Stein GS
  • Calcitonin gene-related peptide (CGRP) increases intracellular free Ca2+ concentrations but not cyclic AMP formation in CGRP receptor-positive osteosarcoma cells (OHS-4).
    Cytokine Volume: 11 Page(s): 200 - 207
    03/01/1999 Authors: Drissi H; Lieberherr M; Hott M; Marie PJ; Lasmoles F
  • Activation of phospholipase C-beta1 via Galphaq/11 during calcium mobilization by calcitonin gene-related peptide.
    J Biol Chem Volume: 273 Page(s): 20168 - 20174
    08/07/1998 Authors: Drissi H; Lasmoles F; Le Mellay V; Marie PJ; Lieberherr M
  • Expression of the CT/CGRP gene and its regulation by dibutyryl cyclic adenosine monophosphate in human osteoblastic cells.
    Volume: 12 Page(s): 1805 - 1814
    11/01/1997 Authors: Drissi H; Hott M; Marie PJ; Lasmoles F
  • Sequencing and signaling of CGRP receptor in the human osteosarcoma OHS-4 cell line.
    Volume: 12 Page(s): F391 - F391
    08/01/1997 Authors: Drissi H; Hott M; Lieberherr M; Marie PJ; Lasmoles F
  • Regulation of calcitonin/calcitonin gene related peptide gene expression by retinoic acid, 1,25(OH)1 and D3, and dexamethasone in the OHS-4 human osteosarcoma cell line.
    Volume: 11 Page(s): T514 - T514
    08/01/1996 Authors: Drissi MH; Hott M; Marie PJ; Lasmoles F
  • EXPRESSION OF THE HUMAN CALCITONIN - CALCITONIN-GENE-RELATED PEPTIDE IN AN OSTEOBLAST-LIKE OSTEOSARCOMA CELL-LINE (OHS-4) - STIMULATION BY DIBUTYRL CAMP
    Volume: 10 Page(s): S284 - S284
    08/01/1995 Authors: DRISSI MH; HOTT M; MARIE PJ; LASMOLES F
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