Mark Czaja MD, FAASLD
- Department of Medicine
Adjunct Professor
- (404) 727-4842
-
Emory University School of Medicine
Medicine
615 Michael St. Suite 201
Overview
Mark J. Czaja, MD, FAASLD is a professor of medicine in the Division of Digestive Diseases at the Emory University School of Medicine. Dr. Czaja completed his undergraduate education at Yale University and received an MD from Columbia University. He completed internal medicine clinical training at Case Western Reserve University and gastroenterology/hepatology clinical training at the Albert Einstein College of Medicine. After doing postdoctoral research on hepatic fibrosis at Einstein, Dr. Czaja joined their faculty, where he remained for a number of years before assuming his present position at Emory.
Dr. Czaja's National Institutes of Health (NIH)-funded research attempts to understand the mechanisms of liver injury and hepatocyte death in order to develop new therapeutic approaches to prevent human liver failure. These investigations have defined signal transduction pathways that mediate liver injury from inflammatory factors such as the cytokine tumor necrosis factor and oxidants during toxin-induced liver injury, and regulate the development of steatosis and the progression to steatohepatitis in fatty liver disease. His laboratory first described the metabolism of endogenous cellular lipids through the lysosomal pathway of autophagy, and additional work in his laboratory has delineated functions for autophagy in both hepatocytes and macrophages that limit liver injury.
Dr. Czaja has held numerous positions, including associate editor and editorial board member of major scientific journals as well as chair or member on NIH study sections and national committees. He has served on the Governing Board of the American Association for the Study of Liver Diseases. He is an elected member of the Association of American Physicians as well as a Fellow of the American Association for the Study of Liver Diseases.
Academic Appointment
- Professor of Medicine, Department of Medicine - Division of Digestive Diseases, Emory University
Education
Degrees
- MD from Columbia University
- BA from Yale University
Research
Publications
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Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3.
Sci Rep Volume: 12 Page(s): 15838
09/23/2022 Authors: Mwangi SM; Li G; Balasubramaniam A; Merlin D; Dawson PA; Jang YC; Hart CM; Czaja MJ; Srinivasan S -
Integrated regulation of stress responses, autophagy and survival by altered intracellular iron stores.
Redox Biol Volume: 55 Page(s): 102407
09/01/2022 Authors: Wang Y; Wang M; Liu Y; Tao H; Banerjee S; Srinivasan S; Nemeth E; Czaja MJ; He P -
Redundant Functions of ERK1 and ERK2 Maintain Mouse Liver Homeostasis Through Down-Regulation of Bile Acid Synthesis.
Hepatol Commun Volume: 6 Page(s): 980 - 994
05/01/2022 Authors: Cingolani F; Liu Y; Shen Y; Wen J; Farris AB; Czaja MJ -
Mouse liver injury induces hepatic macrophage FGF23 production.
PLoS One Volume: 17 Page(s): e0264743
01/01/2022 Authors: Kumar P; Liu Y; Shen Y; Maher JJ; Cingolani F; Czaja MJ -
Sex-Specific Regulation of Interferon- Cytotoxicity in Mouse Liver by Autophagy.
Hepatology Volume: 74 Page(s): 2745 - 2758
11/01/2021 Authors: Shen Y; Cingolani F; Malik SA; Wen J; Liu Y; Czaja MJ -
GLIAL CELL DERIVED NEUROTROPHIC FACTOR PREVENTS PALMITATE-INDUCED OXIDATIVE STRESS AND SUPPRESSION OF MITOPHAGY IN HEPATOCYTES BY INCREASING SIRT3 LEVELS
Volume: 160 Page(s): S64 - S64
05/01/2021 Authors: Mwangi SM; Li G; Chandramowlishwaran P; Liu Y; Hart CM; Merlin D; Czaja MJ; Srinivasan S -
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Autophagy Volume: 17 Page(s): 1 - 382
01/01/2021 Authors: Klionsky DJ; Abdel-Aziz AK; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; Abildgaard MH; Abudu YP; Acevedo-Arozena A -
Blocking integrin 47-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis.
J Hepatol Volume: 73 Page(s): 1013 - 1022
11/01/2020 Authors: Rai RP; Liu Y; Iyer SS; Liu S; Gupta B; Desai C; Kumar P; Smith T; Singhi AD; Nusrat A -
Decreased Hepatocyte Autophagy Leads to Synergistic IL-1 and TNF Mouse Liver Injury and Inflammation.
Hepatology Volume: 72 Page(s): 595 - 608
08/01/2020 Authors: Shen Y; Malik SA; Amir M; Kumar P; Cingolani F; Wen J; Liu Y; Zhao E; Farris AB; Raeman R -
Stathmin 1 Induces Murine Hepatocyte Proliferation and Increased Liver Mass.
Hepatol Commun Volume: 4 Page(s): 38 - 49
01/01/2020 Authors: Zhao E; Shen Y; Amir M; Farris AB; Czaja MJ