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Profile

Matthew Woodruff

  • Department of Medicine
    Assistant Professor
  • matthew.charles.woodruff@emory.edu
Head shot of Matthew Woodruff

Overview

We study antibodies, the cells that make them, and the various factors that influence their development and targeting. By merging experimental approaches in both mouse and human systems, we strive to investigate areas central to human health including critical care medicine, vaccination, and immune dysregulation/autoimmune development. Although primarily focused on B cells, we take an intentionally broad and flexible approach to investigation, incorporating diverse experimental methodologies and analytical approaches to deeply understand the context of immune responses. We are particularly interested in the development of novel intervention strategies designed to nudge, redirect, or even fully subvert immune function in the development of protective, well-targeted immunity.

Academic Appointment

  • Assistant Professor, Department of Medicine, Emory University School of Medicine

Education

Degrees

  • PhD from Harvard University
  • BS from Rochester Institute of Technology

Research

Publications

  • Publisher Correction: Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE.
    Nat Immunol Volume: 26 Page(s): 148
    01/01/2025 Authors: Faliti CE; Van TTP; Anam FA; Cheedarla N; Williams ME; Mishra AK; Usman SY; Woodruff MC; Kraker G; Runnstrom MC
  • Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE.
    Nat Immunol Volume: 26 Page(s): 131 - 145
    01/01/2025 Authors: Faliti CE; Van TTP; Anam FA; Cheedarla N; Williams ME; Mishra AK; Usman SY; Woodruff MC; Kraker G; Runnstrom MC
  • Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis.
    Immunity Volume: 57 Page(s): 2772 - 2789.e8
    12/10/2024 Authors: Faliti CE; Mesina M; Choi J; Blanger S; Marshall MA; Tipton CM; Hicks S; Chappa P; Cardenas MA; Abdel-Hakeem M
  • Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity.
    J Allergy Clin Immunol Volume: 154 Page(s): 435 - 446
    08/01/2024 Authors: Runnstrom MC; Lamothe PA; Faliti CE; Cheedarla N; Moreno A; Suthar MS; Nahata R; Ravindran M; Haddad NS; Morrison-Porter A
  • MENSA, a Media Enriched with Newly Synthesized Antibodies, to Identify SARS-CoV-2 Persistence and Latent Viral Reactivation in Long-COVID.
    medRxiv
    07/07/2024 Authors: Haddad NS; Morrison-Porter A; Quehl H; Capric V; Lamothe PA; Anam F; Runnstrom MC; Truong AD; Dixit AN; Woodruff MC
  • Systems biology of B cells in COVID-19.
    Semin Immunol Volume: 72 Page(s): 101875
    03/01/2024 Authors: Woodruff MC; Faliti CE; Sanz I
  • Distinct transcriptomes and autocrine cytokines underpin maturation and survival of antibody-secreting cells in systemic lupus erythematosus.
    Nat Commun Volume: 15 Page(s): 1899
    03/01/2024 Authors: Chen W; Hong S-H; Jenks SA; Anam FA; Tipton CM; Woodruff MC; Hom JR; Cashman KS; Faliti CE; Wang X
  • Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture.
    Sci Rep Volume: 14 Page(s): 3616
    02/13/2024 Authors: Nguyen DC; Saney C; Hentenaar IT; Cabrera-Mora M; Capric V; Woodruff MC; Andrews J; Lonial S; Sanz I; Lee FE-H
  • Majority of human circulating plasmablasts stop blasting: A probable misnomer.
    bioRxiv
    09/13/2023 Authors: Nguyen DC; Saney C; Hentenaar IT; Cabrera-Mora M; Woodruff MC; Andrews J; Lonial S; Sanz I; Lee FE-H
  • Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID.
    Nat Commun Volume: 14 Page(s): 4201
    07/14/2023 Authors: Woodruff MC; Bonham KS; Anam FA; Walker TA; Faliti CE; Ishii Y; Kaminski CY; Ruunstrom MC; Cooper KR; Truong AD
  • Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines.
    Exp Mol Med Volume: 55 Page(s): 1305 - 1313
    07/01/2023 Authors: Lee J; Woodruff MC; Kim EH; Nam J-H
  • SLE Antibody-Secreting Cells Are Characterized by Enhanced Peripheral Maturation and Survival Programs.
    Res Sq
    06/27/2023 Authors: Chen W; Hong S-H; Jenks SA; Anam FA; Tipton CM; Woodruff MC; Hom JR; Cashman KS; Faliti CE; Wang X
  • Poor immunogenicity upon SARS-CoV-2 mRNA vaccinations in autoimmune SLE patients is associated with pronounced EF-mediated responses and anti-BAFF/Belimumab treatment.
    medRxiv
    06/12/2023 Authors: Faliti CE; Anam FA; Cheedarla N; Woodruff MC; Usman SY; Runnstrom MC; Van TTP; Kyu S; Ahmed H; Morrison-Porter A
  • Single-cell analysis of human nasal mucosal IgE antibody secreting cells reveals a newly minted phenotype.
    Mucosal Immunol Volume: 16 Page(s): 287 - 301
    06/01/2023 Authors: Ramonell RP; Brown M; Woodruff MC; Levy JM; Wise SK; DelGaudio J; Duan M; Saney CL; Kyu S; Cashman KS
  • Mild antecedent COVID-19 associated with symptom-specific post-acute sequelae.
    PLoS One Volume: 18 Page(s): e0288391
    01/01/2023 Authors: Walker TA; Truong AD; Summers A; Dixit AN; Goldstein FC; Hajjar I; Echols MR; Woodruff MC; Lee ED; Tekwani S
  • Dysregulated naive B cells and de novo autoreactivity in severe COVID-19.
    Nature Volume: 611 Page(s): 139 - 147
    11/01/2022 Authors: Woodruff MC; Ramonell RP; Haddad NS; Anam FA; Rudolph ME; Walker TA; Truong AD; Dixit AN; Han JE; Cabrera-Mora M
  • COVID-19 and plasma cells: Is there long-lived protection?
    Immunol Rev Volume: 309 Page(s): 40 - 63
    08/01/2022 Authors: Nguyen DC; Lamothe PA; Woodruff MC; Saini AS; Faliti CE; Sanz I; Lee FE-H
  • Reduced COVID-19 Vaccine Response in Patients Treated with Biologic Therapies for Asthma.
    Am J Respir Crit Care Med Volume: 205 Page(s): 1243 - 1245
    05/15/2022 Authors: Runnstrom MC; Morrison-Porter A; Ravindran M; Quehl H; Ramonell RP; Woodruff M; Patel R; Kim C; Haddad NS; Lee FE-H
  • Response under pressure: deploying emerging technologies to understand B-cell-mediated immunity in COVID-19.
    Nat Methods Volume: 19 Page(s): 387 - 391
    04/01/2022 Authors: Woodruff MC; Nguyen DC; Faliti CE; Saini AS; Lee FE-H; Sanz I
  • Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting.
    Life Sci Alliance Volume: 5
    03/01/2022 Authors: Joyner CJ; Ley AM; Nguyen DC; Ali M; Corrado A; Tipton C; Scharer CD; Mi T; Woodruff MC; Hom J
  • Reduced SARS-CoV-2 Vaccine Response in Patients Treated with Biologic Therapies for Asthma and Atopic Dermatitis
    Volume: 149 Page(s): AB319 - AB319
    02/01/2022 Authors: Runnstrom M; Morrison-Porter A; Ravindran M; Quehl H; Ramonell R; Woodruff M; Kalangara M; Anam F; Swerlick R; Swenson C
  • Extrafollicular IgD+ B cells generate IgE antibody secreting cells in the nasal mucosa.
    Mucosal Immunol Volume: 14 Page(s): 1144 - 1159
    09/01/2021 Authors: Corrado A; Ramonell RP; Woodruff MC; Tipton C; Wise S; Levy J; DelGaudio J; Kuruvilla ME; Magliocca KR; Tomar D
  • B cell subset composition segments clinically and serologically distinct groups in chronic cutaneous lupus erythematosus.
    Ann Rheum Dis Volume: 80 Page(s): 1190 - 1200
    09/01/2021 Authors: Jenks SA; Wei C; Bugrovsky R; Hill A; Wang X; Rossi FM; Cashman K; Woodruff MC; Aspey LD; Lim SS
  • Relaxed peripheral tolerance drives broad de novo autoreactivity in severe COVID-19.
    medRxiv
    07/27/2021 Authors: Woodruff MC; Ramonell RP; Saini AS; Haddad NS; Anam FA; Rudolph ME; Bugrovsky R; Hom J; Cashman KS; Nguyen DC
  • Lupus-like extrafollicular B cell responses and autoreactivity are hallmarks of severe COVID-19
    Volume: 206
    05/01/2021 Authors: Woodruff MC; Ramonell RP; Lee FE-H; Sanz I
  • Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19.
    Nat Immunol Volume: 21 Page(s): 1506 - 1516
    12/01/2020 Authors: Woodruff MC; Ramonell RP; Nguyen DC; Cashman KS; Saini AS; Haddad NS; Ley AM; Kyu S; Howell JC; Ozturk T
  • GLaMST: grow lineages along minimum spanning tree for b cell receptor sequencing data.
    BMC Genomics Volume: 21 Page(s): 583
    09/09/2020 Authors: Yang X; Tipton CM; Woodruff MC; Zhou E; Lee FE-H; Sanz I; Qiu P
  • Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
    Elife Volume: 9
    06/09/2020 Authors: Kim EH; Woodruff MC; Grigoryan L; Maier B; Lee SH; Mandal P; Cortese M; Natrajan MS; Ravindran R; Ma H
  • Mucosal IgE antibody secreting cell (ASC) repertoire analysis suggests an extrafollicular developmental program
    Volume: 204
    05/01/2020 Authors: Ramonell RP; Woodruff MC; Saney CL; Duan M; Lee E-H
  • Templated mutagenesis in B cell non-Ig genes
    Volume: 204
    05/01/2020 Authors: Navarrete K; Dale GA; Woodruff MC; Scharer CD; Boss JM; Sanz I; Jacob J
  • Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
    Immunity Volume: 52 Page(s): 203
    01/14/2020 Authors: Jenks SA; Cashman KS; Zumaquero E; Marigorta UM; Patel AV; Wang X; Tomar D; Woodruff MC; Simon Z; Bugrovsky R
  • Understanding and measuring human B-cell tolerance and its breakdown in autoimmune disease.
    Immunol Rev Volume: 292 Page(s): 76 - 89
    11/01/2019 Authors: Cashman KS; Jenks SA; Woodruff MC; Tomar D; Tipton CM; Scharer CD; Eun-Hyung Lee F; Boss JM; Sanz I
  • Extrafollicular responses in humans and SLE.
    Immunol Rev Volume: 288 Page(s): 136 - 148
    03/01/2019 Authors: Jenks SA; Cashman KS; Woodruff MC; Lee FE-H; Sanz I
  • Challenges and Opportunities for Consistent Classification of Human B Cell and Plasma Cell Populations.
    Front Immunol Volume: 10 Page(s): 2458
    01/01/2019 Authors: Sanz I; Wei C; Jenks SA; Cashman KS; Tipton C; Woodruff MC; Hom J; Lee FE-H
  • FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors.
    Cancer Immunol Res Volume: 6 Page(s): 1472 - 1485
    12/01/2018 Authors: Cremasco V; Astarita JL; Grauel AL; Keerthivasan S; MacIsaac K; Woodruff MC; Wu M; Spel L; Santoro S; Amoozgar Z
  • Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
    Immunity Volume: 49 Page(s): 725 - 739.e6
    10/16/2018 Authors: Jenks SA; Cashman KS; Zumaquero E; Marigorta UM; Patel AV; Wang X; Tomar D; Woodruff MC; Simon Z; Bugrovsky R
  • B Cell Competition for Restricted T Cell Help Suppresses Rare-Epitope Responses.
    Cell Rep Volume: 25 Page(s): 321 - 327.e3
    10/09/2018 Authors: Woodruff MC; Kim EH; Luo W; Pulendran B
  • Vaccine adjuvant MF59 promotes the intranodal differentiation of antigen-loaded and activated monocyte-derived dendritic cells.
    PLoS One Volume: 12 Page(s): e0185843
    01/01/2017 Authors: Cioncada R; Maddaluno M; Vo HTM; Woodruff M; Tavarini S; Sammicheli C; Tortoli M; Pezzicoli A; De Gregorio E; Carroll MC
  • The vesicular stomatitis virus matrix protein inhibits NF-B activation in mouse L929 cells.
    Virology Volume: 499 Page(s): 99 - 104
    12/01/2016 Authors: Varble AJ; Ried CD; Hammond WJ; Marquis KA; Woodruff MC; Ferran MC
  • Modeling Lymph Flow and Fluid Exchange with Blood Vessels in Lymph Nodes.
    Lymphat Res Biol Volume: 13 Page(s): 234 - 247
    12/01/2015 Authors: Jafarnejad M; Woodruff MC; Zawieja DC; Carroll MC; Moore JE
  • The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture.
    Nat Immunol Volume: 16 Page(s): 75 - 84
    01/01/2015 Authors: Astarita JL; Cremasco V; Fu J; Darnell MC; Peck JR; Nieves-Bonilla JM; Song K; Kondo Y; Woodruff MC; Gogineni A
  • B cell homeostasis and follicle confines are governed by fibroblastic reticular cells.
    Nat Immunol Volume: 15 Page(s): 973 - 981
    10/01/2014 Authors: Cremasco V; Woodruff MC; Onder L; Cupovic J; Nieves-Bonilla JM; Schildberg FA; Chang J; Cremasco F; Harvey CJ; Wucherpfennig K
  • Trans-nodal migration of resident dendritic cells into medullary interfollicular regions initiates immunity to influenza vaccine.
    J Exp Med Volume: 211 Page(s): 1611 - 1621
    07/28/2014 Authors: Woodruff MC; Heesters BA; Herndon CN; Groom JR; Thomas PG; Luster AD; Turley SJ; Carroll MC
  • B cells regulate CD4+ T cell responses to papain following B cell receptor-independent papain uptake.
    J Immunol Volume: 193 Page(s): 529 - 539
    07/15/2014 Authors: Dwyer DF; Woodruff MC; Carroll MC; Austen KF; Gurish MF
  • Chemokine 'grooming' by cLECs directs DC migration.
    Nat Immunol Volume: 15 Page(s): 595 - 596
    07/01/2014 Authors: Woodruff MC; Turley SJ
  • B cells potently amplify T cellI L-4 responses following non-BCR mediated cysteine protease uptake
    Volume: 192
    05/01/2014 Authors: Dwyer D; Woodruff M; Carroll M; Austen K; Gurish M
  • Contextual analysis of immunological response through whole-organ fluorescent imaging.
    Lymphat Res Biol Volume: 11 Page(s): 121 - 127
    09/01/2013 Authors: Woodruff MC; Herndon CN; Heesters BA; Carroll MC
  • Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.
    Immunity Volume: 37 Page(s): 276 - 289
    08/24/2012 Authors: Acton SE; Astarita JL; Malhotra D; Lukacs-Kornek V; Franz B; Hess PR; Jakus Z; Kuligowski M; Fletcher AL; Elpek KG
  • Rapid activation and migration of lymph node resident dendritic cells in response to Influenza vaccination
    Volume: 188
    05/01/2012 Authors: Woodruff M; Carroll M
  • C3 is required for host protection to influenza
    Volume: 48 Page(s): 1702 - 1702
    08/01/2011 Authors: Carroll M; Woodruff M; Herndon C; Gonzalez SF
  • Trafficking of B cell antigen in lymph nodes.
    Annu Rev Immunol Volume: 29 Page(s): 215 - 233
    01/01/2011 Authors: Gonzalez SF; Degn SE; Pitcher LA; Woodruff M; Heesters BA; Carroll MC
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