Publications

• A randomized proof-of-mechanism trial of TNF antagonism for motivational deficits and related corticostriatal circuitry in depressed patients with high inflammation.
  Mol Psychiatry Volume: 30 Page(s): 1407 - 1417
  04/01/2025 Authors: Treadway MT; Etuk SM; Cooper JA; Hossein S; Hahn E; Betters SA; Liu S; Arulpragasam AR; DeVries BAM; Irfan N
• Neurotransmitter and metabolic effects of interferon-alpha in association with decreased striatal dopamine in a non-human primate model of cytokine-Induced depression.
  Brain Behav Immun Volume: 125 Page(s): 308 - 318
  03/01/2025 Authors: Bekhbat M; Block AM; Dickinson SY; Tharp GK; Bosinger SE; Felger JC
• Sustained effects of repeated levodopa (L-DOPA) administration on reward circuitry, effort-based motivation, and anhedonia in depressed patients with higher inflammation.
  Brain Behav Immun Volume: 125 Page(s): 240 - 248
  03/01/2025 Authors: Bekhbat M; Li Z; Dunlop BW; Treadway MT; Mehta ND; Revill KP; Lucido MJ; Hong C; Ashchi A; Wommack EC
• Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression.
  Compr Psychoneuroendocrinol Volume: 21 Page(s): 100284
  02/01/2025 Authors: Singh A; Bekhbat M; Goldsmith DR; Le N-A; Wommack EC; Li Z; Haroon E; Felger JC
• Glycolytic metabolism: Food for immune cells, fuel for depression?
  Brain Behav Immun Health Volume: 40 Page(s): 100843
  10/01/2024 Authors: Bekhbat M
• A randomized proof-of-mechanism trial of TNF antagonism for motivational anhedonia and related corticostriatal circuitry in depressed patients with high inflammation.
  
  03/05/2024 Authors: Treadway M; Etuk S; Cooper J; Hossein S; Hahn E; Betters S; Liu S; Arulpragasam A; DeVries B; Irfan N
• Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats.
  Stress Volume: 27 Page(s): 2312467
  01/01/2024 Authors: Rowson S; Bekhbat M; Kelly S; Hyer MM; Dyer S; Weinshenker D; Neigh G
• Repeated social defeat stress leads to immunometabolic shifts in innate immune cells of the spleen.
  Brain Behav Immun Health Volume: 34 Page(s): 100690
  12/01/2023 Authors: Bekhbat M; Drake J; Reed EC; Lauten TH; Natour T; Vladimirov VI; Case AJ
• Manufactured tissue-to-tissue barrier chip for modeling the human blood-brain barrier and regulation of cellular trafficking.
  Lab Chip Volume: 23 Page(s): 2990 - 3001
  06/28/2023 Authors: Kim J; Yoon T; Kim P; Bekhbat M; Kang SM; Rho HS; Ahn SI; Kim Y
• Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology.
  Biol Psychiatry Volume: 93 Page(s): 405 - 418
  03/01/2023 Authors: Goldsmith DR; Bekhbat M; Mehta ND; Felger JC
• Immunometabolic Gene Pathways are Associated With Anhedonia and Altered Following a TNF-Alpha Antagonist in Patients With Depression and High Inflammation
  Volume: 47 Page(s): 232 - 232
  12/01/2022 Authors: Bekhbat M; Haroon E; Etuk S; Felger J; Miller A; Treadway M
• Connecting the dots from east to west.
  Brain Behav Immun Health Volume: 26 Page(s): 100569
  12/01/2022 Authors: Kelley KW; Felger J; Bekhbat M
• Sexual arousal after abuse: (Mal)adaptations of the local immune response.
  Brain Behav Immun Volume: 106 Page(s): 127 - 128
  11/01/2022 Authors: Bekhbat M; Turpin RE
• Glucocorticoid Receptor Function and Cognitive Performance in Women With HIV.
  Psychosom Med Volume: 84 Page(s): 893 - 903
  10/01/2022 Authors: Rubin LH; Bekhbat M; Turkson S; Mehta CC; Maki PM; Anastos K; Gustafson D; Spence AB; Milam J; Chow FC
• Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: evidence from a dopamine challenge study.
  Mol Psychiatry Volume: 27 Page(s): 4113 - 4121
  10/01/2022 Authors: Bekhbat M; Li Z; Mehta ND; Treadway MT; Lucido MJ; Woolwine BJ; Haroon E; Miller AH; Felger JC
• Cellular and immunometabolic mechanisms of inflammation in depression: Preliminary findings from single cell RNA sequencing and a tribute to Bruce McEwen.
  Neurobiol Stress Volume: 19 Page(s): 100462
  07/01/2022 Authors: Bekhbat M; Ulukaya GB; Bhasin MK; Felger JC; Miller AH
• Metabolomic and inflammatory signatures of symptom dimensions in major depression.
  Brain Behav Immun Volume: 102 Page(s): 42 - 52
  05/01/2022 Authors: Brydges CR; Bhattacharyya S; Dehkordi SM; Milaneschi Y; Penninx B; Jansen R; Kristal BS; Han X; Arnold M; Kastenmller G
• Inflammation as a Pathophysiologic Pathway to Anhedonia: Mechanisms and Therapeutic Implications.
  Curr Top Behav Neurosci Volume: 58 Page(s): 397 - 419
  01/01/2022 Authors: Bekhbat M; Treadway MT; Felger JC
• Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming.
  Mol Psychiatry Volume: 26 Page(s): 7384 - 7392
  12/01/2021 Authors: Bekhbat M; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
• Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications.
  Pharmacol Rev Volume: 73 Page(s): 1084 - 1117
  07/01/2021 Authors: Lucido MJ; Bekhbat M; Goldsmith DR; Treadway MT; Haroon E; Felger JC; Miller AH
• Transcriptomic Signatures of Inflammation and Metabolic Reprogramming in Peripheral Blood Immune Cells are Implicated in Psychomotor Retardation in Depression
  Volume: 89 Page(s): S377 - S378
  05/01/2021 Authors: Bekhbat M; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
• Adolescent stress sensitizes the adult neuroimmune transcriptome and leads to sex-specific microglial and behavioral phenotypes.
  Neuropsychopharmacology Volume: 46 Page(s): 949 - 958
  04/01/2021 Authors: Bekhbat M; Mukhara D; Dozmorov MG; Stansfield JC; Benusa SD; Hyer MM; Rowson SA; Kelly SD; Qin Z; Dupree JL
• Protein and gene markers of metabolic dysfunction and inflammation together associate with functional connectivity in reward and motor circuits in depression.
  Brain Behav Immun Volume: 88 Page(s): 193 - 202
  08/01/2020 Authors: Goldsmith DR; Bekhbat M; Le N-A; Chen X; Woolwine BJ; Li Z; Haroon E; Felger JC
• Gene signatures in peripheral blood immune cells related to insulin resistance and low tyrosine metabolism define a sub-type of depression with high CRP and anhedonia.
  Brain Behav Immun Volume: 88 Page(s): 161 - 165
  08/01/2020 Authors: Bekhbat M; Treadway MT; Goldsmith DR; Woolwine BJ; Haroon E; Miller AH; Felger JC
• Divergent Inflammatory and Behavioral Manifestation of Chronic Adolescent Stress Effects in Males and Females
  Volume: 82 Page(s): A163 - A163
  07/01/2020 Authors: Bekhbat M; Neigh G
• GENE SIGNATURES RELATED TO INSULIN SIGNALING AND TYROSINE METABOLISM DEFINE A SUB-TYPE OF DEPRESSION WITH ANHEDONIA AND HIGH CRP
  Volume: 82 Page(s): A197 - A197
  07/01/2020 Authors: Bekhbat M; Goldsmith DR; Treadway MT; Woolwine BJ; Haroon E; Miller AH; Felger JC
• Integrating Animal and Human Experimental Models of Anxiety and Depression
  Volume: 82 Page(s): A163 - A163
  07/01/2020 Authors: Cho JH; Bekhbat M; Sheridan JF; Khalsa S; Cho JH
• Severity of Psychomotor Retardation in Depression is Associated With mRNA Enrichment of Inflammatory and Metabolic Signaling Pathways
  Volume: 44 Page(s): 438 - 439
  12/01/2019 Authors: Goldsmith D; Bekhbat M; Woolwine B; Haroon E; Miller A; Felger J
• Severity of psychomotor retardation in depressed patients is associated with mRNA enrichment of toll-like receptor, cytokine and mTOR signaling pathways
  Volume: 81 Page(s): 29 - 29
  10/01/2019 Authors: Bekhbat M; Goldsmith DR; Miller AH; Felger JC
• Chronic adolescent stress sex-specifically alters the hippocampal transcriptome in adulthood.
  Neuropsychopharmacology Volume: 44 Page(s): 1207 - 1215
  06/01/2019 Authors: Rowson SA; Bekhbat M; Kelly SD; Binder EB; Hyer MM; Shaw G; Bent MA; Hodes G; Tharp G; Weinshenker D
• Female wistar rats with a history of chronic adolescent stress demonstrate decreased hippocampal DNA methylation in adulthood
  Volume: 100 Page(s): S25 - S25
  02/01/2019 Authors: Shaw GA; Bekhbat M; Rowson SA; Bent MA; Hodes G; Binder E; Neigh G
• Chronic adolescent stress sex-specifically alters central and peripheral neuro-immune reactivity in rats.
  Brain Behav Immun Volume: 76 Page(s): 248 - 257
  02/01/2019 Authors: Bekhbat M; Howell PA; Rowson SA; Kelly SD; Tansey MG; Neigh GN
• Chronic adolescent stress differentially sensitizes neuro-immune reactivity in male and female rats
  Volume: 76 Page(s): E20 - E20
  02/01/2019 Authors: Bekhbat M; Mukhara D; Dozmorov MJ; Stansfield JC; Benusa SD; Rowson SA; Kelly SD; Tharp GK; Tansey MG; Neigh GN
• Adolescent Stress Alters FKBP5-Glucocorticoid Receptor Interactions in the Adult Hippocampus of Female, but Not Male, Rats
  Volume: 43 Page(s): S398 - S398
  12/01/2018 Authors: Rowson S; Bekhbat M; Kelly S; Binder E; Weinshenker D; Neigh G
• Glucose and lipid-related biomarkers and the antidepressant response to infliximab in patients with treatment-resistant depression.
  Psychoneuroendocrinology Volume: 98 Page(s): 222 - 229
  12/01/2018 Authors: Bekhbat M; Chu K; Le N-A; Woolwine BJ; Haroon E; Miller AH; Felger JC
• HIV and symptoms of depression are independently associated with impaired glucocorticoid signaling.
  Psychoneuroendocrinology Volume: 96 Page(s): 118 - 125
  10/01/2018 Authors: Bekhbat M; Mehta CC; Kelly SD; Vester A; Ofotokun I; Felger J; Wingood G; Anastos K; Gustafson DR; Kassaye S
• Stress-induced neuroimmune priming in males and females: Comparable but not identical.
  Brain Behav Immun Volume: 73 Page(s): 149 - 150
  10/01/2018 Authors: Bekhbat M; Neigh GN
• Measuring corticosterone concentrations over a physiological dynamic range in female rats.
  Physiol Behav Volume: 194 Page(s): 73 - 76
  10/01/2018 Authors: Bekhbat M; Glasper ER; Rowson SA; Kelly SD; Neigh GN
• Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety.
  Brain Behav Immun Volume: 67 Page(s): 1 - 12
  01/01/2018 Authors: Bekhbat M; Neigh GN
• Adolescent Stress Leads to Enduring Enrichment of the NF-kappa-B Pathway in the Hippocampus Without Peripheral Immune Consequences
  Volume: 42 Page(s): S498 - S499
  11/01/2017 Authors: Bekhbat M; Rowson S; Kelly S; Tharp G; Tansey M; Neigh G
• Chronic adolescent stress alters adult regulation of the glucocorticoid receptor
  Volume: 83 Page(s): 9 - 9
  09/01/2017 Authors: Rowson SA; Bekhbat M; Kelly SD; Neigh GN
• Checks and balances: The glucocorticoid receptor and NFB in good times and bad.
  Front Neuroendocrinol Volume: 46 Page(s): 15 - 31
  07/01/2017 Authors: Bekhbat M; Rowson SA; Neigh GN
• Chronic psychological stress and high-fat high-fructose diet disrupt metabolic and inflammatory gene networks in the brain, liver, and gut and promote behavioral deficits in mice.
  Brain Behav Immun Volume: 59 Page(s): 158 - 172
  01/01/2017 Authors: de Sousa Rodrigues ME; Bekhbat M; Houser MC; Chang J; Walker DI; Jones DP; Oller do Nascimento CMP; Barnum CJ; Tansey MG
• Prolonged effects of chronic adolescent stress on the hippocampal transcriptome are sex-specific
  Volume: 71 Page(s): 48 - 48
  09/01/2016 Authors: Rowson SA; Bekhbat M; Kelly SD; Qin Z; Somineni H; Neigh GN
• Brief anesthesia by isoflurane alters plasma corticosterone levels distinctly in male and female rats: Implications for tissue collection methods.
  Behav Brain Res Volume: 305 Page(s): 122 - 125
  05/15/2016 Authors: Bekhbat M; Merrill L; Kelly SD; Lee VK; Neigh GN
• HIV-1 Transgene Leads to Increased Anxiety-like Behavior and Increased Neuroinflammation
  Volume: 79 Page(s): 351S - 351S
  05/01/2016 Authors: Bekhbat M; Rowson SA; Harrell CS; Kelly SD; Gangavelli A; Neigh GN
• Sex Differences in the Adult Rat Transcriptome Following Chronic Adolescent Stress
  Volume: 79 Page(s): 411S - 411S
  05/01/2016 Authors: Rowson SA; Bekhbat M; Kelly SD; Qin Z; Neigh GN
• Neuroinflammation and Behavior in HIV-1 Transgenic Rats Exposed to Chronic Adolescent Stress.
  Front Psychiatry Volume: 7 Page(s): 102
  01/01/2016 Authors: Rowson SA; Harrell CS; Bekhbat M; Gangavelli A; Wu MJ; Kelly SD; Reddy R; Neigh GN
• Diet, development, and sex: Factors of resilience and susceptibility to chronic stress?
  Volume: 61 Page(s): 18
  11/01/2015 Authors: Neigh GN; Harrell CS; Kelly SD; Rowson SA; Bekhbat M
• Neural effects of inflammation, cardiovascular disease, and HIV: Parallel, perpendicular, or progressive?
  Neuroscience Volume: 302 Page(s): 165 - 173
  08/27/2015 Authors: Nemeth CL; Bekhbat M; Neigh GN
• Microglial activation occurs in the absence of anxiety-like behavior following microembolic stroke in female, but not male, rats.
  J Neuroinflammation Volume: 11 Page(s): 174
  11/06/2014 Authors: Nemeth CL; Reddy R; Bekhbat M; Bailey J; Neigh GN