Publications

• CD8+ T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcRIIB.
  Nat Commun Volume: 15 Page(s): 5280
  06/20/2024 Authors: Bennion KB; Liu D; Dawood AS; Wyatt MM; Alexander KL; Abdel-Hakeem MS; Paulos CM; Ford ML
• Coordinated expansion of memory T follicular helper and B cells mediates spontaneous clearance of HCV reinfection.
  Front Immunol Volume: 15 Page(s): 1403769
  01/01/2024 Authors: Eisa M; Gomez-Escobar E; Bdard N; Abdeltawab NF; Flores N; Mazouz S; Fieff-Bdard A; Sakayan P; Gridley J; Abdel-Hakeem MS
• Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ Tcells toward durable effector-like states during chronic antigen exposure.
  Immunity Volume: 56 Page(s): 2699 - 2718.e11
  12/12/2023 Authors: Beltra J-C; Abdel-Hakeem MS; Manne S; Zhang Z; Huang H; Kurachi M; Su L; Picton L; Ngiow SF; Muroyama Y
• Differential immune transcriptomic profiles between vaccinated and resolved HCV reinfected subjects.
  PLoS Pathog Volume: 18 Page(s): e1010968
  11/01/2022 Authors: Mazouz S; Salinas E; Bdard N; Filali A; Khedr O; Swadling L; Abdel-Hakeem MS; Siddique A; Barnes E; Bruneau J
• Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics.
  Nat Immunol Volume: 23 Page(s): 1600 - 1613
  11/01/2022 Authors: Giles JR; Ngiow SF; Manne S; Baxter AE; Khan O; Wang P; Staupe R; Abdel-Hakeem MS; Huang H; Mathew D
• Identification of a Multi-Messenger RNA Signature as Type 2 Diabetes Mellitus Candidate Genes Involved in Crosstalk between Inflammation and Insulin Resistance.
  Biomolecules Volume: 12
  09/02/2022 Authors: Ali HS; Boshra MS; Agwa SHA; Hakeem MSA; Meteini MSE; Matboli M
• MicroRNA-29a attenuates CD8 T cell exhaustion and induces memory-like CD8 T cells during chronic infection.
  Proc Natl Acad Sci U S A Volume: 119 Page(s): e2106083119
  04/26/2022 Authors: Stelekati E; Cai Z; Manne S; Chen Z; Beltra J-C; Buchness LA; Leng X; Ristin S; Nzingha K; Ekshyyan V
• Editorial: T cell exhaustion; mechanisms of induction, modulation, and recovery.
  Front Immunol Volume: 13 Page(s): 1122530
  01/01/2022 Authors: Abdel-Hakeem MS
• Signaling Through FcRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19.
  Front Immunol Volume: 13 Page(s): 834988
  01/01/2022 Authors: Apostolidis SA; Sarkar A; Giannini HM; Goel RR; Mathew D; Suzuki A; Baxter AE; Greenplate AR; Alanio C; Abdel-Hakeem M
• Author Correction: Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation.
  Nat Immunol Volume: 22 Page(s): 1465
  11/01/2021 Authors: Abdel-Hakeem MS; Manne S; Beltra J-C; Stelekati E; Chen Z; Nzingha K; Ali M-A; Johnson JL; Giles JR; Mathew D
• Expansion of Unique Hepatitis C Virus-Specific Public CD8+ T Cell Clonotypes during Acute Infection and Reinfection.
  J Immunol Volume: 207 Page(s): 1180 - 1193
  08/15/2021 Authors: Mazouz S; Boisvert M; Abdel-Hakeem MS; Khedr O; Bruneau J; Shoukry NH
• Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation.
  Nat Immunol Volume: 22 Page(s): 1008 - 1019
  08/01/2021 Authors: Abdel-Hakeem MS; Manne S; Beltra J-C; Stelekati E; Chen Z; Nzingha K; Ali M-A; Johnson JL; Giles JR; Mathew D
• The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation.
  Brain Volume: 144 Page(s): 1670 - 1683
  07/28/2021 Authors: Benallegue N; Kebir H; Kapoor R; Crockett A; Li C; Cheslow L; Abdel-Hakeem MS; Gesualdi J; Miller MC; Wherry EJ
• Signaling through FcRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19.
  bioRxiv
  05/03/2021 Authors: Apostolidis SA; Sarkar A; Giannini HM; Goel RR; Mathew D; Suzuki A; Baxter AE; Greenplate AR; Alanio C; Abdel-Hakeem M
• Impact of IL10, MTP, SOD2, and APOE Gene Polymorphisms on the Severity of Liver Fibrosis Induced by HCV Genotype 4.
  Viruses Volume: 13
  04/20/2021 Authors: Hemeda AA; Ahmad Mohamed A; Aziz RK; Abdel-Hakeem MS; Ali-Tammam M
• Invivo CD8+ Tcell CRISPR screening reveals control by Fli1 in infection and cancer.
  Cell Volume: 184 Page(s): 1262 - 1280.e22
  03/04/2021 Authors: Chen Z; Arai E; Khan O; Zhang Z; Ngiow SF; He Y; Huang H; Manne S; Cao Z; Baxter AE
• Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage.
  Sci Immunol Volume: 6
  01/15/2021 Authors: Johnnidis JB; Muroyama Y; Ngiow SF; Chen Z; Manne S; Cai Z; Song S; Platt JM; Schenkel JM; Abdel-Hakeem M
• Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.
  Immunity Volume: 52 Page(s): 825 - 841.e8
  05/19/2020 Authors: Beltra J-C; Manne S; Abdel-Hakeem MS; Kurachi M; Giles JR; Chen Z; Casella V; Ngiow SF; Khan O; Huang YJ
• The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection.
  Proc Natl Acad Sci U S A Volume: 116 Page(s): 11916 - 11925
  06/11/2019 Authors: Kotzin JJ; Iseka F; Wright J; Basavappa MG; Clark ML; Ali M-A; Abdel-Hakeem MS; Robertson TF; Mowel WK; Joannas L
• CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer.
  Annu Rev Immunol Volume: 37 Page(s): 457 - 495
  04/26/2019 Authors: McLane LM; Abdel-Hakeem MS; Wherry EJ
• Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries.
  Viruses Volume: 11
  01/27/2019 Authors: Abdel-Hakeem MS
• Glycogen synthase kinase 3 inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism.
  Sci Rep Volume: 7 Page(s): 2495
  05/31/2017 Authors: Sarhan MA; Abdel-Hakeem MS; Mason AL; Tyrrell DL; Houghton M
• Reprogramming of exhausted T cells following elimination of chronic antigen exposure
  Volume: 198
  05/01/2017 Authors: Abdel-Hakeem M; Khan O; Stelekati E; Ali M-A; Wherry EJ
• Selective expansion of high functional avidity memory CD8 T cell clonotypes during hepatitis C virus reinfection and clearance.
  PLoS Pathog Volume: 13 Page(s): e1006191
  02/01/2017 Authors: Abdel-Hakeem MS; Boisvert M; Bruneau J; Soudeyns H; Shoukry NH
• HCV RNA Activates APCs via TLR7/TLR8 While Virus Selectively Stimulates Macrophages Without Inducing Antiviral Responses.
  Sci Rep Volume: 6 Page(s): 29447
  07/07/2016 Authors: Zhang Y; El-Far M; Dupuy FP; Abdel-Hakeem MS; He Z; Procopio FA; Shi Y; Haddad EK; Ancuta P; Sekaly R-P
• High avidity and functionality of virus-specific CD8 T cells associated with protection during HCV reinfection
  Volume: 194
  05/01/2015 Authors: Boisvert M; Abdel-Hakeem M; Bruneau J; Soudeyns H; Shoukry N
• Signatures of protective memory immune responses during hepatitis C virus reinfection.
  Gastroenterology Volume: 147 Page(s): 870 - 881.e8
  10/01/2014 Authors: Abdel-Hakeem MS; Bdard N; Murphy D; Bruneau J; Shoukry NH
• Protective immunity against hepatitis C: many shades of gray.
  Front Immunol Volume: 5 Page(s): 274
  01/01/2014 Authors: Abdel-Hakeem MS; Shoukry NH
• Comparison of immune restoration in early versus late alpha interferon therapy against hepatitis C virus.
  J Virol Volume: 84 Page(s): 10429 - 10435
  10/01/2010 Authors: Abdel-Hakeem MS; Bdard N; Badr G; Ostrowski M; Skaly RP; Bruneau J; Willems B; Heathcote EJ; Shoukry NH
• Early interferon therapy for hepatitis C virus infection rescues polyfunctional, long-lived CD8+ memory T cells.
  J Virol Volume: 82 Page(s): 10017 - 10031
  10/01/2008 Authors: Badr G; Bdard N; Abdel-Hakeem MS; Trautmann L; Willems B; Villeneuve J-P; Haddad EK; Skaly RP; Bruneau J; Shoukry NH