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Profile

Longhu Zhou

  • Department of Pediatrics
    Instructor
  • lzhou8@emory.edu
Head shot of Longhu Zhou

Education

Degrees

  • PhD Organic Chemistry from Zhejiang University

Research

Publications

  • Synthesis of Novel N4-Hydrocytidine Analogs as Potential Anti-SARS-CoV-2 Agents.
    Pharmaceuticals (Basel) Volume: 15
    09/14/2022 Authors: Amblard F; LeCher JC; De R; Goh SL; Li C; Kasthuri M; Biteau N; Zhou L; Tber Z; Downs-Bowen J
  • 7-Deaza-7-fluoro-2'-C-methyladenosine inhibits Zika virus infection and viral-induced neuroinflammation.
    Antiviral Res Volume: 180 Page(s): 104855
    08/01/2020 Authors: Del Sarto JL; Rocha RDPF; Bassit L; Olmo IG; Valiate B; Queiroz-Junior CM; Pedrosa CDSG; Ribeiro FM; Guimares MZ; Rehen S
  • Intracellular metabolism and potential cardiotoxicity of a -D-2'-C-methyl-2,6-diaminopurine ribonucleoside phosphoramidate that inhibits hepatitis C virus replication.
    Nucleosides Nucleotides Nucleic Acids Volume: 39 Page(s): 204 - 224
    01/01/2020 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Ehteshami M; Jiang Y; Amblard F; Coats SJ
  • Novel influenza polymerase PB2 inhibitors for the treatment of influenza A infection.
    Bioorg Med Chem Lett Volume: 29 Page(s): 126639
    10/15/2019 Authors: Zhang H; Zhou L; Amichai S; Zandi K; Cox B; Schinazi R; Amblard F
  • Nucleoside Analogs with Antiviral Activity against Yellow Fever Virus.
    Antimicrob Agents Chemother Volume: 63
    09/01/2019 Authors: Zandi K; Amblard F; Amichai S; Bassit L; Tao S; Jiang Y; Zhou L; Ollinger Russell O; Mengshetti S; Schinazi RF
  • Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses.
    Antimicrob Agents Chemother Volume: 63
    07/01/2019 Authors: Zandi K; Bassit L; Amblard F; Cox BD; Hassandarvish P; Moghaddam E; Yueh A; Libanio Rodrigues GO; Passos I; Costa VV
  • Synthetic efforts towards the preparation of 2 '-dihalogenated nucleotide prodrugs
    Volume: 257
    03/31/2019 Authors: Mengshetti S; Zhou L; Sari O; De Shutter C; Zhou S; Chen Z; Zhang H; Khalil A; Li H; Ovadia R
  • Discovery of a Series of 2'--Fluoro,2'--bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
    J Med Chem Volume: 62 Page(s): 1859 - 1874
    02/28/2019 Authors: Mengshetti S; Zhou L; Sari O; De Schutter C; Zhang H; Cho JH; Tao S; Bassit LC; Verma K; Domaoal RA
  • Nucleotide Substrate Specificity of Anti-Hepatitis C Virus Nucleoside Analogs for Human Mitochondrial RNA Polymerase.
    Antimicrob Agents Chemother Volume: 61
    08/01/2017 Authors: Ehteshami M; Zhou L; Amiralaei S; Shelton JR; Cho JH; Zhang H; Li H; Lu X; Ozturk T; Stanton R
  • 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
    J Med Chem Volume: 60 Page(s): 5424 - 5437
    07/13/2017 Authors: Zhou S; Mahmoud S; Liu P; Zhou L; Ehteshami M; Bassit L; Tao S; Domaoal RA; Sari O; Schutter CD
  • Substrates and Inhibitors of SAMHD1.
    PLoS One Volume: 12 Page(s): e0169052
    01/01/2017 Authors: Hollenbaugh JA; Shelton J; Tao S; Amiralaei S; Liu P; Lu X; Goetze RW; Zhou L; Nettles JH; Schinazi RF
  • Biochemical Characterization of the Active Anti-Hepatitis C Virus Metabolites of 2,6-Diaminopurine Ribonucleoside Prodrug Compared to Sofosbuvir and BMS-986094.
    Antimicrob Agents Chemother Volume: 60 Page(s): 4659 - 4669
    08/01/2016 Authors: Ehteshami M; Tao S; Ozturk T; Zhou L; Cho JH; Zhang H; Amiralaei S; Shelton JR; Lu X; Khalil A
  • Synthesis and Evaluation of 2,6-Modified Purine 2'-C-Methyl Ribonucleosides as Inhibitors of HCV Replication.
    ACS Med Chem Lett Volume: 7 Page(s): 17 - 22
    01/14/2016 Authors: Zhou L; Zhang H; Tao S; Ehteshami M; Cho JH; McBrayer TR; Tharnish P; Whitaker T; Amblard F; Coats SJ
  • NOVEL CAPSID ASSEMBLY EFFECTORS INHIBIT HBV CCCDNA FORMATION IN AN HBEAG REPORTER CELL-BASED ASSAY
    Volume: 64 Page(s): S162 - S162
    01/01/2016 Authors: Bassit L; Boucle S; Amblard F; Zhou L; Zhang HW; Hsiao H-M; Ozturk T; Russell O; Schinazi RF
  • -D-2'-C-Methyl-2,6-diaminopurine Ribonucleoside Phosphoramidates are Potent and Selective Inhibitors of Hepatitis C Virus (HCV) and Are Bioconverted Intracellularly to Bioactive 2,6-Diaminopurine and Guanosine 5'-Triphosphate Forms.
    J Med Chem Volume: 58 Page(s): 3445 - 3458
    04/23/2015 Authors: Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Pradere U; Cho JH
  • Structural informatics modeling of Daclatasvir and analogs reveals asymmetric binding to HCV-NS5A: Dual mechanisms responsible for picomolar activity and acquired resistance
    Volume: 249
    03/22/2015 Authors: Nettles J; Stanton R; Broyde J; Amblard F; Zhang H; Zhou L; Shi J; McBrayer T; Whitaker T; Coats S
  • Asymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition.
    J Med Chem Volume: 57 Page(s): 10031 - 10043
    12/11/2014 Authors: Nettles JH; Stanton RA; Broyde J; Amblard F; Zhang H; Zhou L; Shi J; McBrayer TR; Whitaker T; Coats SJ
  • Chutes and ladders in hepatitis C nucleoside drug development.
    Antiviral Res Volume: 102 Page(s): 119 - 147
    02/01/2014 Authors: Coats SJ; Garnier-Amblard EC; Amblard F; Ehteshami M; Amiralaei S; Zhang H; Zhou L; Boucle SRL; Lu X; Bondada L
  • Comparison of Three 2 '-C-Methyl Guanosine Prodrugs for Hepatitis C including a Novel beta-D-2 '-C-Me-2,6-Diaminopurine Ribonucleoside Phosphoramidate (RS-1389): Interspecies Hepatocyte and Human Cardiomyocyte Metabolism Profiles
    Volume: 60 Page(s): 1170A - 1171A
    01/01/2014 Authors: Tao S; Zhou L; Zhang H; Zhou S; Amiralaei S; Shelton J; Coats SJ; Schinazi RF
  • Adenosine Dioxolane Nucleoside Phosphoramidates as Antiviral Agents for Human Immunodeficiency and Hepatitis B Viruses.
    ACS Med Chem Lett Volume: 4 Page(s): 747 - 751
    08/08/2013 Authors: Bondada L; Detorio M; Bassit L; Tao S; Montero CM; Singletary TM; Zhang H; Zhou L; Cho J-H; Coats SJ
  • Synthesis and evaluation of Janus type nucleosides as potential HCV NS5B polymerase inhibitors.
    Bioorg Med Chem Lett Volume: 23 Page(s): 3385 - 3388
    06/01/2013 Authors: Zhou L; Amblard F; Zhang H; McBrayer TR; Detorio MA; Whitaker T; Coats SJ; Schinazi RF
  • Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
    Bioorg Med Chem Lett Volume: 23 Page(s): 2031 - 2034
    04/01/2013 Authors: Amblard F; Zhang H; Zhou L; Shi J; Bobeck DR; Nettles JH; Chavre S; McBrayer TR; Tharnish P; Whitaker T
  • Biochemical characterization of beta-D-2 '-C-methyl-2,6-diaminopurine-ribonucleoside-5 '-triphosphate as a potent inhibitor of hepatitis C virus (HCV) polymerase
    Volume: 18 Page(s): A10 - A10
    01/01/2013 Authors: Ehteshami M; Amiralaei S; Shelton JR; Tao S; Suesserman JE; Zhang H-W; Zhou L; Coats SJ; Schinazi RF
  • beta-D-2 '-C-Me-2,6-diaminopurine ribonucleoside phosphoramidates are potent and selective inhibitors of hepatitis C virus (HCV) and are bioconverted intracellularly to bioactive 2,6-diaminopurine- and guanosine-5 '-triphosphate forms
    Volume: 18 Page(s): A57 - A57
    01/01/2013 Authors: Schinazi RF; Zhou L; Zhang H-W; Tao S; Bassit L; Whitaker T; McBrayer TR; Ehteshami M; Amiralaei S; Detorio M
  • Scaleable processes for the synthesis of (-)--D-2,6-diaminopurine dioxolane (Amdoxovir, DAPD) and (-)--D-2-aminopurine dioxolane (APD).
    Tetrahedron Volume: 68 Page(s): 5738 - 5743
    07/22/2012 Authors: Zhou L; Coats SJ; Zhang H; Junxing S; Bobeck DR; Schinazi RF
  • Synthesis and evaluation of novel potent HCV NS5A inhibitors.
    Bioorg Med Chem Lett Volume: 22 Page(s): 4864 - 4868
    07/15/2012 Authors: Zhang H; Zhou L; Amblard F; Shi J; Bobeck DR; Tao S; McBrayer TR; Tharnish PM; Whitaker T; Coats SJ
  • Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors.
    Bioorg Med Chem Lett Volume: 22 Page(s): 3488 - 3491
    05/15/2012 Authors: Shi J; Zhou L; Amblard F; Bobeck DR; Zhang H; Liu P; Bondada L; McBrayer TR; Tharnish PM; Whitaker T
  • Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates.
    Bioorg Med Chem Lett Volume: 21 Page(s): 7094 - 7098
    12/01/2011 Authors: Shi J; Zhou L; Zhang H; McBrayer TR; Detorio MA; Johns M; Bassit L; Powdrill MH; Whitaker T; Coats SJ
  • Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
    Bioorg Med Chem Lett Volume: 21 Page(s): 6788 - 6792
    11/15/2011 Authors: Zhang H-W; Zhou L; Coats SJ; McBrayer TR; Tharnish PM; Bondada L; Detorio M; Amichai SA; Johns MD; Whitaker T
  • Synthesis and characterization of picomolar inhibitors of HCV NS5A in hepatocytes
    Volume: 16 Page(s): A22 - A22
    01/01/2011 Authors: Schinazi RF; Zhang H-W; Zhou L; Amblard F; Bobeck DR; Shi J; Whitaker T; McBrayer TR; Tharnish PM; Coats SJ
  • Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
    Antivir Chem Chemother Volume: 20 Page(s): 99 - 106
    10/19/2009 Authors: Rondla R; Coats SJ; McBrayer TR; Grier J; Johns M; Tharnish PM; Whitaker T; Zhou L; Schinazi RF
  • Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat.
    Bioorg Med Chem Volume: 14 Page(s): 7862 - 7874
    12/01/2006 Authors: Zhou L; Thakur CS; Molinaro RJ; Paranjape JM; Hoppes R; Jeang K-T; Silverman RH; Torrence PF
  • Assembling a smallpox biodefense by interrogating 5-substituted pyrimidine nucleoside chemical space.
    Antiviral Res Volume: 71 Page(s): 201 - 205
    09/01/2006 Authors: Fan X; Zhang X; Zhou L; Keith KA; Kern ER; Torrence PF
  • Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.
    J Med Chem Volume: 49 Page(s): 4052 - 4054
    07/13/2006 Authors: Fan X; Zhang X; Zhou L; Keith KA; Prichard MN; Kern ER; Torrence PF
  • A pyrimidine-pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity.
    Bioorg Med Chem Lett Volume: 16 Page(s): 3224 - 3228
    06/15/2006 Authors: Fan X; Zhang X; Zhou L; Keith KA; Kern ER; Torrence PF
  • 5-(Dimethoxymethyl)-2'-deoxyuridine: a novel gem diether nucleoside with anti-orthopoxvirus activity.
    J Med Chem Volume: 49 Page(s): 3377 - 3382
    06/01/2006 Authors: Fan X; Zhang X; Zhou L; Keith KA; Kern ER; Torrence PF
  • Synthesis and antiviral activities of 1,2,3-triazole functionalized thymidines: 1,3-dipolar cycloaddition for efficient regioselective diversity generation.
    Antivir Chem Chemother Volume: 16 Page(s): 375 - 383
    01/01/2005 Authors: Zhou L; Amer A; Korn M; Burda R; Balzarini J; De Clercq E; Kern ER; Torrence PF
  • Endowing RNase H-inactive antisense with catalytic activity: 2-5A-morphants.
    Bioconjug Chem Volume: 16 Page(s): 383 - 390
    01/01/2005 Authors: Zhou L; Civitello ER; Gupta N; Silverman RH; Molinaro RJ; Anderson DE; Torrence PF
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