Linsheng Zhang MD, PhD

Department of Pathology and Laboratory Medicine
Associate Professor

Pathology and Laboratory Medicine,
531 Asbury Circle, Suite N252A,

Overview

Director, Molecular Genetic Pathology Fellowship Program
Assistant Director, Molecular Diagnostic Laboratory, Emory Medical Laboratories

Clinical Service: Hematopathology and Molecular Diagnostics
Research Interests: Cancer mutation profiling

VOLUNTEER AND LEADERSHIP POSITIONS:
- Chair, Checkpath Hematopathology Committee, American Society for Clinical Pathology (ASCP)
- Member, Molecular Oncology Committee, College of American Pathologists (CAP)
- Image Editor, American Society for Clinical Pathology (ASCP) LabQ
- Editorial Board Member, Molecular pathology section editor, Human Pathology Reports

Google Scholar Profile
Learning and Education Webpage

Academic Appointment

Associate Professor, Department of Pathology and Laboratory Medicine, Emory University School of Medicine

Education

Degrees

PhD (Hematology) from Beijing Medical University
MS (Clinical Medicine) from Third Military Medical University
BMed (MD equivalent) from Third Military Medical University

Research

Publications

Clinicopathologic and Whole Exome Sequencing Analyzes of High-Grade Serous Carcinoma-Like Carcinoma of the Breast Reveal Unique Genetic Profile and Poor Clinical Outcome.
Am J Surg Pathol
05/23/2025 Authors: Hsiao W-Y; Nguyen TTA; Yang W; Yan H; Li Z; Zhang L; Yang J; Li X
TP53 mutations in myeloid neoplasms: implications for accurate laboratory detection, diagnosis, and treatment.
Lab Med Volume: 55 Page(s): 686 - 699
11/04/2024 Authors: Zhang L; Abro B; Campbell A; Ding Y
Extracavitary primary effusion lymphoma presenting as a solitary brain mass.
CNS Oncol Volume: 13 Page(s): 2357535
06/06/2024 Authors: Javadi T; Morales B; Olson JJ; Kothari S; Zhang L; Abedalthagafi M
EBV-Positive Nodal T- and NK-Cell Lymphoma Mimicking Anaplastic Large Cell Lymphoma: A Case Report.
Hematol Rep Volume: 16 Page(s): 308 - 316
05/23/2024 Authors: Abro B; Allen P; Asakrah S; Bradley K; Zhang L
Measurable (Minimal) Residual Disease in Myelodysplastic Neoplasms (MDS): Current State and Perspectives.
Cancers (Basel) Volume: 16
04/15/2024 Authors: Zhang L; Deeb G; Deeb KK; Vale C; Peker Barclift D; Papadantonakis N
Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study.
Arch Pathol Lab Med Volume: 148 Page(s): 310 - 317
03/01/2024 Authors: Bidot S; Yin J; Zhou P; Zhang L; Deeb KK; Smith G; Hill CE; Xiu J; Bilen MA; Case KB
Molecular Genetic Profile of Myelofibrosis: Implications in the Diagnosis, Prognosis, and Treatment Advancements.
Cancers (Basel) Volume: 16
01/25/2024 Authors: Verma T; Papadantonakis N; Peker Barclift D; Zhang L
Genetic Profiling of African American Patients With Prostatic Adenocarcinoma Metastatic to the Lymph Nodes: A Pilot Study
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
06/19/2023 Authors: Bidot S; Yin J; Zhou P; Zhang L; Deeb K; Smith GH; Hill C; Xiu J; Bilen M; Case K
Bilateral breast Rosai-Dorfman disease screen detected by mammography.
Clin Case Rep Volume: 11 Page(s): e6983
03/01/2023 Authors: Sumner C; Salem K; Abunimer L; Ewaz A; Zhang L; Monsrud A; Calisi N
Essential Thrombocythemia and Post-Essential Thrombocythemia Myelofibrosis: Updates on Diagnosis, Clinical Aspects, and Management.
Lab Med Volume: 54 Page(s): 13 - 22
01/05/2023 Authors: Puglianini OC; Peker D; Zhang L; Papadantonakis N
Single Multiplex Master Mix versus Dual Master Mix Method Comparison for T-cell Receptor Clonality Assessment
Volume: 24 Page(s): S47 - S48
10/01/2022 Authors: Drumheller B; Broadfoot B; Saade R; Ma Y; Lyons C; Jones H; Hill C; Zhang L
Spiking Synthetic SNPs for Specimen Tracking as a Quality Improvement Initiative
Volume: 24 Page(s): S150 - S150
10/01/2022 Authors: Broadfoot B; Drumheller B; Lewis J; Ma Y; Ojo A; Saade R; Schneider T; Smith G; Zhang L
Revealing molecular architecture of FLT3 internal tandem duplication: Development and clinical validation of a web-based application to generate accurate nomenclature.
Int J Lab Hematol Volume: 44 Page(s): 918 - 927
10/01/2022 Authors: Ding Y; Smith GH; Deeb K; Schneider T; Campbell A; Zhang L
Comment on "A Novel COL1A1-CAMTA1 Rearrangement in Cranial Fasciitis".
Int J Surg Pathol Volume: 30 Page(s): 839 - 840
10/01/2022 Authors: Deeb KK; Li S; Zhang L
Update on the Classification of and Diagnostic Approaches to Mature T-Cell Lymphomas.
Arch Pathol Lab Med Volume: 146 Page(s): 947 - 952
08/01/2022 Authors: Zhang X; Zhou J; Han X; Wang E; Zhang L
Mixed Neuroendocrine-acinar Neoplasms of the Stomach: A Contemporary Clinicopathologic Analysis of Seven Cases with Molecular Profile Studies
Volume: 102 Page(s): 464 - 465
03/01/2022 Authors: Hsiao WY; Lui SK; Wang H; Zhang L; Krasinskas A; Zheng W
Clinical Validation of a Web Application to Create Nomenclature of FLT3 Internal Tandem Duplication from Next Generation Sequencing Result
Volume: 35 Page(s): 1070 - 1071
03/01/2022 Authors: Ding Y; Smith G; Deeb K; Campbell A; Zhang L
Clinical Validation of a Web Application to Create Nomenclature of FLT3 Internal Tandem Duplication from Next Generation Sequencing Result
Volume: 102 Page(s): 1070 - 1071
03/01/2022 Authors: Ding Y; Smith G; Deeb K; Campbell A; Zhang L
Genetic Profiling of African American Patients with Prostatic Adenocarcinoma Metastatic to the Lymph Node
Volume: 102 Page(s): 571 - 572
03/01/2022 Authors: Bidot S; Yin J; Zhang L; Deeb K; Hill C; Xiu J; Bilen M; Case K; Harik L
Reactive Intralymphovascular Immunoblastic Proliferations Mimicking Aggressive Lymphomas.
Am J Surg Pathol Volume: 46 Page(s): 326 - 335
03/01/2022 Authors: Fang H; Wang W; Zhang L; Shen Q; Yuan J; Reichard KK; Hu Z; Medeiros LJ
Metastatic low-grade endometrial stromal sarcoma after 24years: A case report and review of recent molecular genetics.
Diagn Cytopathol Volume: 49 Page(s): E99 - E105
03/01/2021 Authors: Mindiola-Romero AE; Liu X; Dillon JL; Talarico M; Smith G; Zhang L; Linos K
Primary cutaneous Ewing sarcoma with diffuse S100/SOX10 positivity and pseudoalveolar pattern: An extraordinarily rare case highlighting a potential pitfall with significant repercussions.
J Cutan Pathol Volume: 48 Page(s): 302 - 308
02/01/2021 Authors: Evangelou Z; Zhang L; Tafe LJ; Azzouz L; Grada Z; Linos K
Subcutaneous desmoplastic small round-cell tumor: An unusual primary location expanding the differential of superficial round-cell tumors.
J Cutan Pathol Volume: 47 Page(s): 768 - 775
08/01/2020 Authors: Asadbeigi SN; Zhang L; Linos K
Association Between PD-L1 Expression and c-Met Alterations in Non-Small Cell Lung Carcinoma
Volume: 100 Page(s): 1821 - 1821
03/01/2020 Authors: Tenney T; Sica G; Saxe D; Owonikoko T; Ramalingam S; Zhang L
Association Between PD-L1 Expression and c-Met Alterations in Non-Small Cell Lung Carcinoma
Volume: 33 Page(s): 1821 - 1821
03/01/2020 Authors: Tenney T; Sica G; Saxe D; Owonikoko T; Ramalingam S; Zhang L
Comparison of Mutated Gene Frequencies in Acute Myeloid Leukemia
Volume: 33 Page(s): 1886 - 1887
03/01/2020 Authors: Myers C; Shebelut C; Zhang L
Comparison of Mutated Gene Frequencies in Acute Myeloid Leukemia
Volume: 100 Page(s): 1886 - 1887
03/01/2020 Authors: Myers C; Shebelut C; Zhang L
Copy Number Variant Detection by Targeted Gene Next-Generation Sequencing
Volume: 21 Page(s): 1150 - 1151
11/01/2019 Authors: Myers CE; Nguyen HL; Hauenstein J; Saxe DF; Smith GH; Hill CE; Zhang L; Deeb KK
Mantle Cell Lymphoma With Mantle Zone Growth Pattern.
Am J Clin Pathol Volume: 152 Page(s): 132 - 145
07/05/2019 Authors: Yuan J; Li S; Liu X; Su RJ; Chen M; Wu X; Zheng G; Smith LM; Wang L; Li Y
Determination of Accuracy, Reproducibility, and Repeatability for the Clinical Validation of a 75 Gene Myeloid Mutation Panel
Volume: 21 Page(s): S29 - S29
05/01/2019 Authors: Dolderer D; Deeb K; Nguyen H; Hill C; Smith G; Magee S; Zhang L
Determination of the DNA Input and Limit of Detection in the Clinical Validation of a Next Generation Sequencing (NGS)-Based Myeloid Gene Panel
Volume: 21 Page(s): S30 - S30
05/01/2019 Authors: Nguyen H; Zhang L; Dolderer D; Smith G; Magee S; Hill C; Deeb K
A novel case of an aggressive superficial spindle cell sarcoma in an adult resembling fibrosarcomatous dermatofibrosarcoma protuberans and harboring an EML4-NTRK3 fusion.
J Cutan Pathol Volume: 45 Page(s): 933 - 939
12/01/2018 Authors: Olson N; Rouhi O; Zhang L; Angeles C; Bridge J; Lopez-Terrada D; Royce T; Linos K
Clinically Significant Germline Variants Detected by Mutation Profiling of Non-small Cell Lung Cancer in Patients with Multiple Nodules Harboring Different Somatic Mutations
Volume: 20 Page(s): 980 - 980
11/01/2018 Authors: Fellowship EP; Dolderer D; Ngo NT; Hill CE; Zhang L
Confirmation of Novel Gene Fusions Detected by Next-Generation Sequencing using Enriched RNA Libraries
Volume: 20 Page(s): 976 - 976
11/01/2018 Authors: Ngo NT; Nguyen H; Almradi A; Hill CE; Zhang L
EML4-ALK Rearrangement and Its Therapeutic Implications in Inflammatory Myofibroblastic Tumors.
Oncologist Volume: 23 Page(s): 1127 - 1132
10/01/2018 Authors: Vargas-Madueno F; Gould E; Valor R; Ngo N; Zhang L; Villalona-Calero MA
Validation of a Customized Bioinformatics Pipeline for a Clinical Next-Generation Sequencing Test Targeting Solid Tumor-Associated Variants.
J Mol Diagn Volume: 20 Page(s): 355 - 365
05/01/2018 Authors: Schneider T; Smith GH; Rossi MR; Hill CE; Zhang L
cBioportal as a Tool to Monitor and Analyze Next Generation Sequencing Based Melanoma Mutation Profiling Data for Quality Control and Quality Assurance
Volume: 98 Page(s): 192 - 192
03/01/2018 Authors: Almradi A; Xie M; Ngo NT; Smith G; Hill C; Zhang L
Application of cBioPortal Local Platform for Quality Assurance and Quality Control of Next Generation Sequencing Mutation Data on Lung Adenocarcinomas
Volume: 98 Page(s): 594 - 595
03/01/2018 Authors: Ngo NT; Xie M; Almradi A; Smith G; Hill C; Zhang L
cBioportal as a Tool to Monitor and Analyze Next Generation Sequencing Based Melanoma Mutation Profiling Data for Quality Control and Quality Assurance
Volume: 31 Page(s): 192 - 192
03/01/2018 Authors: Almradi A; Xie M; Ngo NT; Smith G; Hill C; Zhang L
Application of cBioPortal Local Platform for Quality Assurance and Quality Control of Next Generation Sequencing Mutation Data on Lung Adenocarcinomas
Volume: 31 Page(s): 594 - 595
03/01/2018 Authors: Ngo NT; Xie M; Almradi A; Smith G; Hill C; Zhang L
Clinical Validation of a Molecular Barcoded Amplicon-based Next Generation Sequencing Test for Mutation Profiling of Myeloid Neoplasms
Volume: 19 Page(s): 960 - 960
11/01/2017 Authors: Yang T; Almradi A; Smith G; Hill C; Zhang L
Splicing Site Mutation in MET Gene Potentially Associated with Exon 14 Skipping Detected by DNA-Based Next Generation Sequencing in Lung Adenocarcinoma
Volume: 19 Page(s): 1035 - 1035
11/01/2017 Authors: Rouhi O; Ngo NT; Yang T; Rossi MR; Hill CE; Zhang L
Multimodality Technologies in the Assessment of Hematolymphoid Neoplasms.
Arch Pathol Lab Med Volume: 141 Page(s): 341 - 354
03/01/2017 Authors: Li S; Jaye DL; Bradley KT; Zhang L; Saxe D; Deeb G; Hill CE; Mann KP
Clinical Value of Targeted Panel Next-Generation Sequencing in BCR-ABL1-Negative Myeloproliferative Neoplasms
Volume: 30 Page(s): 387A - 387A
02/01/2017 Authors: Yang T; Box A; Winton E; Hill CE; Zhang L
Clinical Value of Targeted Panel Next-Generation Sequencing in BCR-ABL1-Negative Myeloproliferative Neoplasms
Volume: 97 Page(s): 387A - 387A
02/01/2017 Authors: Yang T; Box A; Winton E; Hill CE; Zhang L
Proficiency Testing for Next-Generation Sequencing: Multi-Institutional FASTQ File Exchange Leads To Improved Bioinformatics Workflows for Reporting Insertion-Deletion Mutations
Volume: 18 Page(s): 991 - 991
11/01/2016 Authors: Schneider TM; Wang J; Davies KD; Gruidl M; Woolworth-Hirschhom J; Kadri S; Box AH; Clay MR; Farooqi MS; Hill CE
Multi-Institutional FASTQ File Exchange as a Means of Proficiency Testing for Next-Generation Sequencing Bioinformatics and Variant Interpretation.
J Mol Diagn Volume: 18 Page(s): 572 - 579
07/01/2016 Authors: Davies KD; Farooqi MS; Gruidl M; Hill CE; Woolworth-Hirschhorn J; Jones H; Jones KL; Magliocco A; Mitui M; O'Neill PH
Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies.
J Mol Diagn Volume: 18 Page(s): 299 - 315
03/01/2016 Authors: Fisher KE; Zhang L; Wang J; Smith GH; Newman S; Schneider TM; Pillai RN; Kudchadkar RR; Owonikoko TK; Ramalingam SS
Clinical significance of quantitative monitoring and mutational analysis of BCR-ABL1 transcript in Philadelphia chromosome positive B lymphoblastic leukemia.
Leuk Lymphoma Volume: 57 Page(s): 364 - 369
02/01/2016 Authors: Zhang L; Ramjit RT; Hill CE; Arellano M; Khoury HJ; Mann KP
Data Analysis of RNA-Seq of the Bone Marrow from Patients with Myeloid Neoplasms Using Multiple Bioinformatic Pipelines
Volume: 96 Page(s): 400A - 400A
02/01/2016 Authors: Schneider T; Smith G; Newman S; Zhang L
Data Analysis of RNA-Seq of the Bone Marrow from Patients with Myeloid Neoplasms Using Multiple Bioinformatic Pipelines
Volume: 29 Page(s): 400A - 400A
02/01/2016 Authors: Schneider T; Smith G; Newman S; Zhang L
Detection of Chromosome Translocations Associated with Myeloid Malignancies Using Targeted RNA Next-Generation Sequencing Panel
Volume: 17 Page(s): 777 - 778
11/01/2015 Authors: Schneider TM; Smith G; Hill C; Zhang L
Development and validation of CALR mutation testing for clinical diagnosis.
Am J Clin Pathol Volume: 144 Page(s): 738 - 745
11/01/2015 Authors: Maier CL; Fisher KE; Jones HH; Hill CE; Mann KP; Zhang L
SOX2 Expression in EGFR and KRAS Mutated Lung Adenocarcinomas
Volume: 27 Page(s): 476A - 476A
02/01/2014 Authors: Fatima N; Fisher K; Rossi MR; Zhang L; Owanikoko T; Ramalingam S; Khuri F; Gal A; Cohen C; Sica G
SOX2 Expression in EGFR and KRAS Mutated Lung Adenocarcinomas
Volume: 94 Page(s): 476A - 476A
02/01/2014 Authors: Fatima N; Fisher K; Rossi MR; Zhang L; Owanikoko T; Ramalingam S; Khuri F; Gal A; Cohen C; Sica G
Molecular Detection of Clinically Actionable Lung Cancer Mutations: Multiplexed Single Gene Assays Versus Next-Generation Sequencing Following Target-Enrichment
Volume: 27 Page(s): 476A - 477A
02/01/2014 Authors: Fisher KE; Wang J; Pillai RN; Owonikoko TK; Ramalingam SR; Khuri FR; Gal AA; Mann KP; Hill CE; Sica GL
Molecular Detection of Clinically Actionable Lung Cancer Mutations: Multiplexed Single Gene Assays Versus Next-Generation Sequencing Following Target-Enrichment
Volume: 94 Page(s): 476A - 477A
02/01/2014 Authors: Fisher KE; Wang J; Pillai RN; Owonikoko TK; Ramalingam SR; Khuri FR; Gal AA; Mann KP; Hill CE; Sica GL
Section II: hematolymphoid malignancies.
Curr Probl Cancer Volume: 38 Page(s): 159 - 174
01/01/2014 Authors: Zhang L; Rossi MR; Fisher KE
Introduction: molecular genomics of cancer: linking diagnostic testing and clinical therapy.
Curr Probl Cancer Volume: 38 Page(s): 142 - 143
01/01/2014 Authors: Fisher KE; Neill SG; Smith GH; Pillai RN; Kudchadkar RR; Zhang L; Rossi MR
Systemic mastocytosis with associated myeloproliferative neoplasm with t(8;19)(p12;q13.1) and abnormality of FGFR1: report of a unique case.
Int J Clin Exp Pathol Volume: 7 Page(s): 801 - 807
01/01/2014 Authors: Duckworth CB; Zhang L; Li S
Using RNA-Seq, SNP-CN and Targeted Deep Sequencing To Improve The Diagnostic Paradigm In Multiple Myeloma
Volume: 122
11/15/2013 Authors: Rossi MR; Newman S; Nooka AK; Kaufman JL; Bahlis NJ; Neri P; Matulis SM; Bernal-Mizrachi L; Gupta VA; Varma A
Improved Presentation of Molecular Assay Results Using Self-contained Interactive HTML/JavaScript Documents
Volume: 140 Page(s): 437 - 437
09/01/2013 Authors: Smith GH; Wang J; Zhang L; Carter AB; Hill CE; Mann KP
Langerhans Cell Sarcoma Arising from Chronic Lymphocytic Lymphoma/Small Lymphocytic Leukemia: Lineage Analysis and BRAF V600E Mutation Study.
N Am J Med Sci Volume: 5 Page(s): 386 - 391
06/01/2013 Authors: Chen W; Jaffe R; Zhang L; Hill C; Block AM; Sait S; Song B; Liu Y; Cai D
Comparison of the Performance Characteristics of Two Commercially Available Real-time RT-qPCR Assays for the Quantification of BCR/ABL1 Transcripts on the WHO International Scale
Volume: 14 Page(s): 662 - 662
11/01/2012 Authors: Ramjit RT; Stowell SR; Hill CE; Nabila S; Zhang L; Mann KP
Clonal diversity analysis using SNP microarray: a new prognostic tool for chronic lymphocytic leukemia.
Cancer Genet Volume: 204 Page(s): 654 - 665
12/01/2011 Authors: Zhang L; Znoyko I; Costa LJ; Conlin LK; Daber RD; Self SE; Wolff DJ
Mitochondrial disorders of DNA polymerase dysfunction: from anatomic to molecular pathology diagnosis.
Arch Pathol Lab Med Volume: 135 Page(s): 925 - 934
07/01/2011 Authors: Zhang L; Chan SSL; Wolff DJ
Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation.
Blood Volume: 111 Page(s): 1193 - 1200
02/01/2008 Authors: Zhang L; Fried FB; Guo H; Friedman AD
Identification of a region on the outer surface of the CBFbeta-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization.
Oncogene Volume: 25 Page(s): 7289 - 7296
11/23/2006 Authors: Zhang L; D'Costa J; Kummalue T; Civin CI; Friedman AD
Mutational analysis of the CBF beta-SMMHC assembly competence domain identifies a surface critical for multimerization and inhibition of RUNX1/AML1
BLOOD Volume: 106 Page(s): 800A - 800A
11/16/2005 Authors: Zhang LS; D'Costa J; Kummalue T; Moreno I; Civin CI; Hiebert SW; Friedman AD
Staphylococcus intermedius produces a functional agr autoinducing peptide containing a cyclic lactone.
J Bacteriol Volume: 187 Page(s): 3139 - 3150
05/01/2005 Authors: Ji G; Pei W; Zhang L; Qiu R; Lin J; Benito Y; Lina G; Novick RP
Identification of the putative staphylococcal AgrB catalytic residues involving the proteolytic cleavage of AgrD to generate autoinducing peptide.
J Biol Chem Volume: 280 Page(s): 16695 - 16704
04/29/2005 Authors: Qiu R; Pei W; Zhang L; Lin J; Ji G
Identification of a staphylococcal AgrB segment(s) responsible for group-specific processing of AgrD by gene swapping.
J Bacteriol Volume: 186 Page(s): 6706 - 6713
10/01/2004 Authors: Zhang L; Ji G
Membrane anchoring of the AgrD N-terminal amphipathic region is required for its processing to produce a quorum-sensing pheromone in Staphylococcus aureus.
J Biol Chem Volume: 279 Page(s): 19448 - 19456
05/07/2004 Authors: Zhang L; Lin J; Ji G
Transmembrane topology of AgrB, the protein involved in the post-translational modification of AgrD in Staphylococcus aureus.
J Biol Chem Volume: 277 Page(s): 34736 - 34742
09/20/2002 Authors: Zhang L; Gray L; Novick RP; Ji G