Liyong Lin PhD

Department of Radiation Oncology
Professor

Winship Cancer Institute at Emory University
Department of Radiation Oncology
1365 Clifton Rd.
Emory Proton Therapy Center
615 Peachtree St NE

Overview

Liyong Lin, PhD, FAAPM, DABR, is a professor in the Department of Radiation Oncology at Emory University School of Medicine. An ABR board certified medical physicist, Dr. Lin's expertise includes commissioning, quality assurance and Monte Carlo characterization of pencil beam scanning proton therapy systems.

He received his PhD in Medical Physics from University of Wisconsin-Madison. He then completed a two year clinical postdoc at University of Florida Proton Therapy Institute.

Dr. Lin's research interest is in developing Monte Carlo dose calculation and Image Guided Proton Therapy physics framework for heterogeneous and moving tumors. He serves on the editorial board of Journal of Applied Clinical Medical Physics, as well as on American Association of Physicists in Medicine's Task Group 290 "Respiratory Motion Management for Particle Therapy" and on Particle Therapy Co-Operative Group's Imaging Sub-committee.

Academic Appointment

Professor, Department of Radiation Oncology, Emory University School of Medicine
Adjunct Assistant Professor, School of Mechanical Engineering, Georgia Institute of Technology

Education

Degrees

PHD from University of Wisconsin–Madison
M.S from University of Wisconsin–Madison
M.S from Shanghai Jiao Tong University
B.S from Shanghai Jiao Tong University

Research

Focus

Establish golden beam data for Pencil Beam Scanning Proton Therapy
Establish golden beam data for Pencil Beam Scanning Proton Therapy across dose calculation/treatment planning systems and treatment delivery systems
Image Guided Pencil Beam Scanning Proton Therapy
Reduce uncertainties in Image Guided Pencil Beam Scanning Proton Therapy to exploit the full advantages of proton therapy including CBCT, motion mitigation, dose benchmarks and quality assurance methods

Publications

Embracing the Future of Clinical Trials in Radiation Therapy: An NRG Oncology CIRO Technology Retreat Whitepaper on Pioneering Technologies and AI-Driven Solutions.
Int J Radiat Oncol Biol Phys
01/22/2025 Authors: Xiao Y; Benedict S; Cui Y; Glide-Hurst C; Graves S; Jia X; Kry SF; Li H; Lin L; Matuszak M
Characterizing devices for validation of dose, dose rate, and LET in ultra high dose rate proton irradiations.
Med Phys Volume: 51 Page(s): 8411 - 8422
11/01/2024 Authors: Harrison N; Charyyev S; Oancea C; Stanforth A; Gelover E; Zhou S; Dynan WS; Zhang T; Biegalski S; Lin L
Time structures of proton pencil beam scanning delivery on a microsecond scale measured with a pixelated semiconductor detector Timepix3.
J Appl Clin Med Phys Volume: 25 Page(s): e14486
09/01/2024 Authors: Shen J; Ding X; Charyyev S; Liang X; Oancea C; Wang P; Rule WG; Liu W; Bues M; Lin L
NRG Oncology and Particle Therapy Co-Operative Group Patterns of Practice Survey and Consensus Recommendations on Pencil-Beam Scanning Proton Stereotactic Body Radiation Therapy and Hypofractionated Radiation Therapy for Thoracic Malignancies.
Int J Radiat Oncol Biol Phys Volume: 119 Page(s): 1208 - 1221
07/15/2024 Authors: Liu W; Feng H; Taylor PA; Kang M; Shen J; Saini J; Zhou J; Giap HB; Yu NY; Sio TS
Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials.
Int J Radiat Oncol Biol Phys Volume: 119 Page(s): 737 - 749
07/01/2024 Authors: Li H; Mayr NA; Griffin RJ; Zhang H; Pokhrel D; Grams M; Penagaricano J; Chang S; Spraker MB; Kavanaugh J
A Novel Inverse Algorithm To Solve the Integrated Optimization of Dose, Dose Rate, and Linear Energy Transfer of Proton FLASH Therapy With Sparse Filters.
Int J Radiat Oncol Biol Phys Volume: 119 Page(s): 957 - 967
07/01/2024 Authors: Harrison N; Kang M; Liu R; Charyyev S; Wahl N; Liu W; Zhou J; Higgins KA; Simone CB; Bradley JD
Proton 3D dose measurement with a multi-layer strip ionization chamber (MLSIC) device.
Phys Med Biol Volume: 69
06/26/2024 Authors: Zhou S; Chen Q; Haefner J; Smith W; Darafsheh A; Zhao T; Harrison NA; Zhou J; Lin L; Lu W
The Status and Challenges for Prostate Stereotactic Body Radiation Therapy Treatments in United States Proton Therapy Centers: An NRG Oncology Practice Survey.
Int J Part Ther Volume: 11 Page(s): 100020
03/01/2024 Authors: Shen J; Taylor PA; Vargas CE; Kang M; Saini J; Zhou J; Wang P; Liu W; Simone CB; Xiao Y
Proton Pencil-Beam Scanning Stereotactic Body Radiation Therapy and Hypofractionated Radiation Therapy for Thoracic Malignancies: Patterns of Practice Survey and Recommendations for Future Development from NRG Oncology and PTCOG.
ArXiv
02/01/2024 Authors: Liu W; Feng H; Taylor PA; Kang M; Shen J; Saini J; Zhou J; Giap HB; Yu NY; Sio TS
A spot-specific range uncertainty framework for robust optimization of proton therapy treatments.
Med Phys Volume: 50 Page(s): 6554 - 6568
10/01/2023 Authors: Cohilis M; Souris K; Buti G; Chang C-W; Lin L; Lee JA; Sterpin E
MPLA case: I didn't realize those were the expectations!
J Appl Clin Med Phys Volume: 24 Page(s): e14089
08/01/2023 Authors: Simiele SJ; Charyyev S; Lin L; Kim L; Wang D; Gronberg MP; MPLA Cases Subcommittee
Deep learning-based Fast Volumetric Image Generation for Image-guided Proton FLASH Radiotherapy.

07/26/2023 Authors: Chang C-W; Lei Y; Wang T; Tian S; Roper J; Lin L; Bradley J; Liu T; Zhou J; Yang X
An Integrated Physical Optimization Framework for Proton Stereotactic Body Radiation Therapy FLASH Treatment Planning Allows Dose, Dose Rate, and Linear Energy Transfer Optimization Using Patient-Specific Ridge Filters.
Int J Radiat Oncol Biol Phys Volume: 116 Page(s): 949 - 959
07/15/2023 Authors: Liu R; Charyyev S; Wahl N; Liu W; Kang M; Zhou J; Yang X; Baltazar F; Palkowitsch M; Higgins K
Measurement of the time structure of FLASH beams using prompt gamma rays and secondary neutrons as surrogates.
Volume: 68
07/12/2023 Authors: Charyyev S; Liu R; Yang X; Zhou J; Dhabaan A; Dynan WS; Oancea C; Lin L
Feasibility study of hybrid inverse planning with transmission beams and single-energy spread-out Bragg peaks for proton FLASH radiotherapy.
Med Phys Volume: 50 Page(s): 3687 - 3700
06/01/2023 Authors: Ma C; Yang X; Chang C-W; Liu R; Bohannon D; Lin L; Liu T; Tian S; Zhou J
A component method to delineate surgical spine implants for proton Monte Carlo dose calculation.
J Appl Clin Med Phys Volume: 24 Page(s): e13800
01/01/2023 Authors: Chang C-W; Charyyev S; Harms J; Slopsema R; Wolf J; Refai D; Yoon T; McDonald MW; Bradley JD; Leng S
Characterization of 250 MeV Protons from the Varian ProBeam PBS System for FLASH Radiation Therapy.
Int J Part Ther Volume: 9 Page(s): 279 - 289
01/01/2023 Authors: Charyyev S; Chang C-W; Zhu M; Lin L; Langen K; Dhabaan A
Proton liver stereotactic body radiation therapy: Treatment techniques and dosimetry feasibility from a single institution.
J Radiosurg SBRT Volume: 9 Page(s): 33 - 42
01/01/2023 Authors: Zhou J; Kang M; Wang Y; Higgins KA; Simone CB; Patel P; McDonald MW; Lin L; Bohannon D
Advances in treatment planning and management for the safety and accuracy of lung stereotactic body radiation therapy using proton pencil beam scanning: Simulation, planning, quality assurance, and delivery recommendations.
J Radiosurg SBRT Volume: 9 Page(s): 53 - 62
01/01/2023 Authors: Kang M; Choi JI; Souris K; Zhou J; Yu G; Shepherd AF; Ohri N; Lazarev S; Lin L; Lin H
Stereotactic body proton therapy for non-small cell lung cancer: Clinical indications and recommendations.
J Radiosurg SBRT Volume: 9 Page(s): 17 - 32
01/01/2023 Authors: McMillan MT; Kang M; Shepherd AF; Liu W; Lin L; Lin H; Simone CB
Safety and efficacy of stereotactic body proton therapy for high-risk lung tumors.
J Radiosurg SBRT Volume: 9 Page(s): 63 - 74
01/01/2023 Authors: McMillan MT; Shepherd AF; Kang M; Lin L; Shaverdian N; Wu AJ; Gelblum DY; Ohri N; Lazarev S; Xu L
Proton SBRT is ready to move past uncertainties and towards improved clinical outcomes.
J Radiosurg SBRT Volume: 9 Page(s): 3 - 6
01/01/2023 Authors: Simone CB; Lin L
Proton stereotactic body radiation therapy as a new treatment regimen: Technical development and limitation with initial clinical experience.
J Radiosurg SBRT Volume: 9 Page(s): 1
01/01/2023 Authors: Lin L; Yin FF; Higgins KA; Ryu S; Simone CB
Validation of the Quantum Physics Processes Underlying the Integrated Optimization of Proton FLASH Radiotherapy

12/19/2022 Authors: Harrison N; Charyyev S; Oancea C; Stanforth A; Zhou S; Dynan W; Zhang T; Biegalski S; Lin L
Validation of a deep learning-based material estimation model for Monte Carlo dose calculation in proton therapy.
Phys Med Biol Volume: 67
10/19/2022 Authors: Chang C-W; Zhou S; Gao Y; Lin L; Liu T; Bradley JD; Zhang T; Zhou J; Yang X
A multi-layer strip ionization chamber (MLSIC) device for proton pencil beam scan quality assurance.
Phys Med Biol Volume: 67
08/23/2022 Authors: Zhou S; Rao W; Chen Q; Tan Y; Smith W; Sun B; Zhou J; Chang C-W; Lin L; Darafsheh A
Validation of a CBCT-Based Online Evaluation Workflow for Proton Therapy
Volume: 49 Page(s): E871 - E871
06/01/2022 Authors: Chang C; Nilsson R; Andersson S; Bohannon D; Lin L; Patel S; Patel P; Langen K; Bradley J; Liu T
Realtime Volumetric Image for Target Localization During Proton FLASH Radiotherapy
Volume: 49 Page(s): E489 - E489
06/01/2022 Authors: Chang C; Lei Y; Wang T; Zhou J; Lin L; Roper J; Higgins K; Liu T; Bradley J; Yang X
DECT-Based Material Mass Density Mapping for Proton Monte Carlo Dose Calculation Using Physics-Informed Deep Learning
Volume: 49 Page(s): E526 - E527
06/01/2022 Authors: Chang C; Gao Y; Wang T; Lei Y; Wang Q; Bradley J; Liu T; Lin L; Zhou J; Yang X
Development of a Proton SBRT FLASH Treatment Technique with Dose, Dose Rate, and LET Optimization Using Patient Specific 3D Ridge Filters
Volume: 49 Page(s): E429 - E429
06/01/2022 Authors: Liu R; Charyyev S; Wahl N; Liu W; Zhou J; Yang X; Dynan W; Kang M; Higgins K; Bradley J
Feasibility of Combining Transmission Beams and Spread-Out Single-Energy Bragg Peaks for Proton FLASH Radiotherapy
Volume: 49 Page(s): E427 - E428
06/01/2022 Authors: Ma C; Yang X; Liu R; Lin L; Bohannon D; Liu T; Bradley J; Zhou J
Predictive Maintenance Model for Early Detection of Plan Adaptation in Proton Head and Neck Treatment
Volume: 49 Page(s): E710 - E710
06/01/2022 Authors: Bohannon D; Chang C; Janopaul-naylor J; Ma C; Diamond Z; Lin L; Bradley J; Liu T; Yang X; McDonald M
Dual-energy CT based mass density and relative stopping power estimation for proton therapy using physics-informed deep learning.
Phys Med Biol Volume: 67
05/26/2022 Authors: Chang C-W; Gao Y; Wang T; Lei Y; Wang Q; Pan S; Sudhyadhom A; Bradley JD; Liu T; Lin L
Onboard cone-beam CT-based replan evaluation for head and neck proton therapy.
J Appl Clin Med Phys Volume: 23 Page(s): e13550
05/01/2022 Authors: Stanforth A; Lin L; Beitler JJ; Janopaul-Naylor JR; Chang C-W; Press RH; Patel SA; Zhao J; Eaton B; Schreibmann EE
AAPM Task Group Report 290: Respiratory motion management for particle therapy.
Med Phys Volume: 49 Page(s): e50 - e81
04/01/2022 Authors: Li H; Dong L; Bert C; Chang J; Flampouri S; Jee K-W; Lin L; Moyers M; Mori S; Rottmann J
Dosimetric Uncertainties in Dominant Intraprostatic Lesion Simultaneous Boost Using Intensity Modulated Proton Therapy.
Adv Radiat Oncol Volume: 7 Page(s): 100826
01/01/2022 Authors: Zhou J; Yang X; Chang C-W; Tian S; Wang T; Lin L; Wang Y; Janopaul-Naylor JR; Patel P; Demoor JD
Cone Beam CT-Based Online Evaluation in Two Minutes Using a Commercial Treatment Planning Software for Proton Therapy
Volume: 111 Page(s): E153 - E153
11/01/2021 Authors: Zhou J; Nilsson R; Andersson S; Patel SA; Yang X; Lin L; Rudra S; Patel PR; Eaton BR; Bradley JD
Cone Beam CT-Based Online Evaluation in Two Minutes Using a Commercial Treatment Planning Software for Proton Therapy.
Volume: 111 Page(s): e153
11/01/2021 Authors: Zhou J; Nilsson R; Andersson S; Patel SA; Yang X; Lin L; Rudra S; Patel PR; Eaton BR; Bradley JD
A Novel Component Method to Delineate Surgical Spine Implants for Proton Monte Carlo Dose Calculation
Volume: 48
06/01/2021 Authors: Chang C; Charyyev S; Harms J; Slopsema R; Wolf J; Refai D; Yoon T; McDonald M; Bradley J; Leng S
Feasibility of 3D Printed Ridge Filter to Enable SBRT FLASH Therapy Using Scanning Proton Beam
Volume: 48
06/01/2021 Authors: Liu R; Charyyev S; Zhou J; Yang X; Liu T; McDonald M; Higgins K; Bradley J; Lin L
Synthetic Dual-Energy CT for MRI-Based Proton Therapy Treatment Planning Using Label-GAN
Volume: 48
06/01/2021 Authors: Liu R; Lei Y; Wang T; Zhou J; Roper J; Lin L; McDonald M; Bradley J; Liu T; Yang X
Robust Optimization of Proton Therapy Treatments Using a Variable Range Uncertainty
Volume: 48
06/01/2021 Authors: Cohilis M; Sterpin E; Chang C; Rivas S; Lin L; Lee J; Souris K
Synthetic dual-energy CT for MRI-only based proton therapy treatment planning using label-GAN.
Phys Med Biol Volume: 66 Page(s): 065014
03/09/2021 Authors: Liu R; Lei Y; Wang T; Zhou J; Roper J; Lin L; McDonald MW; Bradley JD; Curran WJ; Liu T
A novel proton counting detector and method for the validation of tissue and implant material maps for Monte Carlo dose calculation.
Phys Med Biol Volume: 66 Page(s): 045003
02/02/2021 Authors: Charyyev S; Chang C-W; Harms J; Oancea C; Yoon ST; Yang X; Zhang T; Zhou J; Lin L
NRG Oncology Survey of Monte Carlo Dose Calculation Use in US Proton Therapy Centers.
Int J Part Ther Volume: 8 Page(s): 73 - 81
01/01/2021 Authors: Lin L; Taylor PA; Shen J; Saini J; Kang M; Simone CB; Bradley JD; Li Z; Xiao Y
Learning-Based Stopping Power Mapping on Dual-Energy CT for Proton Radiation Therapy.
Int J Part Ther Volume: 7 Page(s): 46 - 60
01/01/2021 Authors: Wang T; Lei Y; Harms J; Ghavidel B; Lin L; Beitler JJ; McDonald M; Curran WJ; Liu T; Zhou J
National Survey of Monte Carlo Dose Calculation Use in US Proton Therapy Centers
Volume: 108 Page(s): E271 - E271
11/01/2020 Authors: Lin L; Taylor PA; Shen J; Saini J; Kang M; Simone CB; Bradley JD; Li Z; Xiao Y
Online Prediction of Dosimetric Changes in Dominant Intraprostatic Lesion Simultaneous Boost Using Intensity Modulated Proton Therapy
Volume: 108 Page(s): S170 - S171
11/01/2020 Authors: Zhou J; Tian S; Patel SA; Janopaul-Naylor J; Chang CW; Lin L; Jung J; Bohannon D; Demoor J; Godette KD
Beam characteristics of the first clinical 360 rotational single gantry room scanning pencil beam proton treatment system and comparisons against a multi-room system.
J Appl Clin Med Phys Volume: 21 Page(s): 266 - 271
09/01/2020 Authors: Shang C; Evans G; Rahman M; Lin L
Optimization of hexagonal-pattern minibeams for spatially fractionated radiotherapy using proton beam scanning.
Med Phys Volume: 47 Page(s): 3485 - 3495
08/01/2020 Authors: Charyyev S; Artz M; Szalkowski G; Chang C-W; Stanforth A; Lin L; Zhang R; Wang C-KC
Technical Note: Integrating an open source Monte Carlo code "MCsquare" for clinical use in intensity-modulated proton therapy.
Med Phys Volume: 47 Page(s): 2558 - 2574
06/01/2020 Authors: Deng W; Younkin JE; Souris K; Huang S; Augustine K; Fatyga M; Ding X; Cohilis M; Bues M; Shan J
Prediction of Dosimetric Variation in Dominant Intraprostatic Lesion with Simultaneous Integrated Boost for Pencil Beam Proton Therapy
Volume: 47 Page(s): E434 - E434
06/01/2020 Authors: Chang C; Bohannon D; Stiles K; Stanforth A; Tian S; Wang Y; Lin L; Patel P; Liu T; Yang X
Energy Layer Filtering and Splitting in Breath Sampled Re-Painting for Lung SBRT Using Pencil Beam Scanning Proton Beams
Volume: 47 Page(s): E764 - E765
06/01/2020 Authors: Stiles K; Chang C; Stanforth A; Wang Y; Demoor J; Higgins K; McDonald M; Bradley J; Liu T; Yang X
Voxel-Specific Characterization of An Anthropomorphic Phantom as the Ultimate Ground Truth to Evaluate the Accuracy of Various Imaging Methods of Proton Therapy
Volume: 47 Page(s): E880 - E880
06/01/2020 Authors: Chang C; Harms J; Charyyev S; Zhou J; Yang X; Lin L
Fast Monte Carlo Dose Estimation for Proton Therapy Using a Dual-Pyramid Deep Learning Framework
Volume: 47 Page(s): E780 - E781
06/01/2020 Authors: Harms J; Lei Y; Charyyev S; Stanforth A; Zhou J; Lin L; Curran W; Liu T; Yang X
Timing Features of 4D Detector and Pencil Beam Scanning Proton Therapy Can Improve WET Map Accuracy with Deep CNN
Volume: 47 Page(s): E866 - E866
06/01/2020 Authors: Chang C; Zhou S; Zhou J; Yang X; Zhang T; Lin L
Beam Characteristics of the First Clinical 360-Rotational Compact Scanning Pencil Beam Proton Treatment System and Differences From a Multi-Room System
Volume: 47 Page(s): E709 - E710
06/01/2020 Authors: Shang C; Evans G; Rahman M; Lin L
Measurements of LET, Nuclear Halo, Energy and Angular Spectra of a Proton Spot Scanning Beam with a Hybrid Semiconductor Detector
Volume: 47 Page(s): E470 - E470
06/01/2020 Authors: Charyyev S; Chang C; Stanforth A; Harms J; Oancea C; Lin L
Derivation of Photon Cross Section Coefficients of Virtual Monoenergetic CT Images for Radiotherapy Treatment Planning
Volume: 47 Page(s): E599 - E599
06/01/2020 Authors: Harms J; Chang C; Charyyev S; Zhou J; Yang X; Lin L
A standardized commissioning framework of Monte Carlo dose calculation algorithms for proton pencil beam scanning treatment planning systems.
Med Phys Volume: 47 Page(s): 1545 - 1557
04/01/2020 Authors: Chang C-W; Huang S; Harms J; Zhou J; Zhang R; Dhabaan A; Slopsema R; Kang M; Liu T; McDonald M
Predicted Secondary Malignancies following Proton versus Photon Radiation for Oropharyngeal Cancers.
Int J Part Ther Volume: 6 Page(s): 1 - 10
01/01/2020 Authors: Jain V; Irmen P; O'Reilly S; Vogel JH; Lin L; Lin A
Nuclear halo measurements for accurate prediction of field size factor in a Varian ProBeam proton PBS system.
J Appl Clin Med Phys Volume: 21 Page(s): 197 - 204
01/01/2020 Authors: Harms J; Chang C-W; Zhang R; Lin L
MRI-based treatment planning for proton radiotherapy: dosimetric validation of a deep learning-based liver synthetic CT generation method.
Phys Med Biol Volume: 64 Page(s): 145015
07/16/2019 Authors: Liu Y; Lei Y; Wang Y; Wang T; Ren L; Lin L; McDonald M; Curran WJ; Liu T; Zhou J
Development of Multilayer/strip Ionization Chamber Array for Proton Pencil Beam Scanning Field Delivery Verification
Volume: 46 Page(s): E412 - E412
06/01/2019 Authors: Zhou S; Zhao T; Sun B; Mutic S; Lin L; Zhang T
Commissioning a Fast and Accurate Monte Carlo Dose Engine (MCsquare) in Intensity-Modulated Proton Therapy
Volume: 46 Page(s): E168 - E168
06/01/2019 Authors: Deng W; Huang S; Souris K; Ding X; Cohilis M; Younkin J; Bues M; Lin L; Shen J; Liu W
Dual-Energy CT-Based Accurate Stopping Power Mapping Using 3D Deep Convolutional Neural Networks for Head-And-Neck Patients
Volume: 46 Page(s): E233 - E233
06/01/2019 Authors: Wang T; Lei Y; Harms J; Liu Y; Ghavidel B; Lin L; Curran W; Beitler J; Liu T; Zhou J
Comparison of Dosimetric Evaluations Using Deformed Planning CT and Deep-Learning Corrected CBCT to Quality Assurance CT for Monitoring Anatomy Changes During Proton Therapy
Volume: 46 Page(s): E250 - E250
06/01/2019 Authors: Stanforth A; Langen K; Lin L; Dhabaan A; Lei Y; Liu Y; Wang Y; Sohn J; McDonald M; Eaton B
MRI-Based Treatment Planning for Liver Photon and Proton Radiotherapy
Volume: 46 Page(s): E318 - E319
06/01/2019 Authors: Liu Y; Lei Y; Wang T; Wang Y; Kayode O; Tian S; Lin L; Liu T; Patel P; Curran W
A Golden Beam Data Commissioning Framework of Monte Carlo Dose Calculation Algorithms of Two Pencil Beam Scanning Proton Therapy Treatment Planning Systems
Volume: 46 Page(s): E167 - E167
06/01/2019 Authors: Chang C; Harms J; Zhang R; Zhou J; Lin Y; Slopsema R; Dhabaan A; Liu T; McDonald M; Langen K
Pseudo Proton Radiography Beam Validation of Monte Carlo Dose Calculation in Two Pencil Beam Scanning Treatment Planning Systems
Volume: 46 Page(s): E592 - E592
06/01/2019 Authors: Chang C; Zhou J; Yang X; Dhabaan A; Zhang R; Liu T; McDonald M; Langen K; Lin L
Deep-Learning-Based Synthetic-CT Generation Method for CBCT-Guided Proton Therapy
Volume: 46 Page(s): E475 - E475
06/01/2019 Authors: Liu Y; Lei Y; Lin L; Dhabaan A; Liu T; Curran W; Zhou J; Yang X
A Most Likely Path (MLP) Validation of Spot Decomposition for Pencil Beam Scanning (PBS) in Proton Radiography (pRG) and Proton CT (pCT)
Volume: 46 Page(s): E181 - E181
06/01/2019 Authors: Sohn J; Liu T; Li X; Lin L; Ding X; Langen K; Eaton B; McDonald M; Curran W; Yang X
Clinical significance of pretreatment tumor growth rate for locally advanced non-small cell lung cancer.
Ann Transl Med Volume: 7 Page(s): 95
03/01/2019 Authors: Osorio B; Yegya-Raman N; Kim S; Simone CB; Theodorou Ross C; Deek MP; Gaines D; Zou W; Lin L; Malhotra J
Validation and application of a fast Monte Carlo algorithm for assessing the clinical impact of approximations in analytical dose calculations for pencil beam scanning proton therapy.
Med Phys Volume: 45 Page(s): 5631 - 5642
12/01/2018 Authors: Huang S; Souris K; Li S; Kang M; Barragan Montero AM; Janssens G; Lin A; Garver E; Ainsley C; Taylor P
Validation and clinical implementation of an accurate Monte Carlo code for pencil beam scanning proton therapy.
J Appl Clin Med Phys Volume: 19 Page(s): 558 - 572
09/01/2018 Authors: Huang S; Kang M; Souris K; Ainsley C; Solberg TD; McDonough JE; Simone CB; Lin L
Proton Beam Therapy for Bronchogenic Adenoid Cystic Carcinoma: Dosimetry, Toxicities, and Outcomes.
Int J Part Ther Volume: 4 Page(s): 1 - 9
01/01/2018 Authors: Verma V; Lin L; Simone CB
Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.
Int J Mol Sci Volume: 18
11/25/2017 Authors: Velalopoulou A; Chatterjee S; Pietrofesa RA; Koziol-White C; Panettieri RA; Lin L; Tuttle S; Berman A; Koumenis C; Christofidou-Solomidou M
Superiority in Robustness of Multifield Optimization Over Single-Field Optimization for Pencil-Beam Proton Therapy for Oropharynx Carcinoma: An Enhanced Robustness Analysis.
Int J Radiat Oncol Biol Phys Volume: 99 Page(s): 738 - 749
11/01/2017 Authors: Sttzer K; Lin A; Kirk M; Lin L
Prospective study of proton-beam radiation therapy for limited-stage small cell lung cancer.
Cancer Volume: 123 Page(s): 4244 - 4251
11/01/2017 Authors: Rwigema J-CM; Verma V; Lin L; Berman AT; Levin WP; Evans TL; Aggarwal C; Rengan R; Langer C; Cohen RB
First Ever Use of Proton Stereotactic Body Radiation Therapy Delivered with Curative Intent to Bilateral Synchronous Primary Renal Cell Carcinomas.
Cureus Volume: 9 Page(s): e1799
10/24/2017 Authors: Frick MA; Chhabra AM; Lin L; Simone CB
Predicted Rate of Secondary Malignancies Following Adjuvant Proton Versus Photon Radiation Therapy for Thymoma.
Int J Radiat Oncol Biol Phys Volume: 99 Page(s): 427 - 433
10/01/2017 Authors: Vogel J; Lin L; Litzky LA; Berman AT; Simone CB
Consensus Guidelines for Implementing Pencil-Beam Scanning Proton Therapy for Thoracic Malignancies on Behalf of the PTCOG Thoracic and Lymphoma Subcommittee.
Int J Radiat Oncol Biol Phys Volume: 99 Page(s): 41 - 50
09/01/2017 Authors: Chang JY; Zhang X; Knopf A; Li H; Mori S; Dong L; Lu H-M; Liu W; Badiyan SN; Both S
Risk of major cardiac events following adjuvant proton versus photon radiation therapy for patients with thymic malignancies.
Acta Oncol Volume: 56 Page(s): 1060 - 1064
08/01/2017 Authors: Vogel J; Lin L; Simone CB; Berman AT
A study of the beam-specific interplay effect in proton pencil beam scanning delivery in lung cancer.
Acta Oncol Volume: 56 Page(s): 531 - 540
04/01/2017 Authors: Kang M; Huang S; Solberg TD; Mayer R; Thomas A; Teo B-KK; McDonough JE; Simone CB; Lin L
A benchmarking method to evaluate the accuracy of a commercial proton monte carlo pencil beam scanning treatment planning system.
J Appl Clin Med Phys Volume: 18 Page(s): 44 - 49
03/01/2017 Authors: Lin L; Huang S; Kang M; Hiltunen P; Vanderstraeten R; Lindberg J; Siljamaki S; Wareing T; Davis I; Barnett A
Evaluation of motion mitigation using abdominal compression in the clinical implementation of pencil beam scanning proton therapy of liver tumors.
Med Phys Volume: 44 Page(s): 703 - 712
02/01/2017 Authors: Lin L; Souris K; Kang M; Glick A; Lin H; Huang S; Sttzer K; Janssens G; Sterpin E; Lee JA
Technical Note: A treatment plan comparison between dynamic collimation and a fixed aperture during spot scanning proton therapy for brain treatment.
Med Phys Volume: 43 Page(s): 4693
08/01/2016 Authors: Smith B; Gelover E; Moignier A; Wang D; Flynn RT; Lin L; Kirk M; Solberg T; Hyer DE
Establishing the feasibility of the dosimetric compliance criteria of RTOG 1308: phase III randomized trial comparing overall survival after photon versus proton radiochemotherapy for inoperable stage II-IIIB NSCLC.
Radiat Oncol Volume: 11 Page(s): 66
05/04/2016 Authors: Giaddui T; Chen W; Yu J; Lin L; Simone CB; Yuan L; Gong YUT; Wu QJ; Mohan R; Zhang X
Theoretical Benefits of Dynamic Collimation in Pencil Beam Scanning Proton Therapy for Brain Tumors: Dosimetric and Radiobiological Metrics.
Int J Radiat Oncol Biol Phys Volume: 95 Page(s): 171 - 180
05/01/2016 Authors: Moignier A; Gelover E; Wang D; Smith B; Flynn R; Kirk M; Lin L; Solberg T; Lin A; Hyer D
First Clinical Investigation of Cone Beam Computed Tomography and Deformable Registration for Adaptive Proton Therapy for Lung Cancer.
Int J Radiat Oncol Biol Phys Volume: 95 Page(s): 549 - 559
05/01/2016 Authors: Veiga C; Janssens G; Teng C-L; Baudier T; Hotoiu L; McClelland JR; Royle G; Lin L; Yin L; Metz J
Prospective study of proton beam radiation therapy for adjuvant and definitive treatment of thymoma and thymic carcinoma: Early response and toxicity assessment.
Radiother Oncol Volume: 118 Page(s): 504 - 509
03/01/2016 Authors: Vogel J; Berman AT; Lin L; Pechet TT; Levin WP; Gabriel P; Khella SL; Singhal S; Kucharczuk JK; Simone CB
Toward improved target conformity for two spot scanning proton therapy delivery systems using dynamic collimation.
Med Phys Volume: 43 Page(s): 1421 - 1427
03/01/2016 Authors: Moignier A; Gelover E; Smith BR; Wang D; Flynn RT; Kirk ML; Lin L; Solberg TD; Lin A; Hyer DE
Beam-specific planning target volumes incorporating 4D CT for pencil beam scanning proton therapy of thoracic tumors.
J Appl Clin Med Phys Volume: 16 Page(s): 5678
11/08/2015 Authors: Lin L; Kang M; Huang S; Mayer R; Thomas A; Solberg TD; McDonough JE; Simone CB
Comparing proton treatment plans of pediatric brain tumors in two pencil beam scanning nozzles with different spot sizes.
J Appl Clin Med Phys Volume: 16 Page(s): 41 - 50
11/08/2015 Authors: Kralik JC; Xi L; Solberg TD; Simone CB; Lin L
Technical Note: Validation of halo modeling for proton pencil beam spot scanning using a quality assurance test pattern.
Med Phys Volume: 42 Page(s): 5138 - 5143
09/01/2015 Authors: Lin L; Huang S; Kang M; Solberg TD; McDonough JE; Ainsley CG
3D printer generated thorax phantom with mobile tumor for radiation dosimetry.
Rev Sci Instrum Volume: 86 Page(s): 074301
07/01/2015 Authors: Mayer R; Liacouras P; Thomas A; Kang M; Lin L; Simone CB
Use of a novel two-dimensional ionization chamber array for pencil beam scanning proton therapy beam quality assurance.
J Appl Clin Med Phys Volume: 16 Page(s): 5323
05/08/2015 Authors: Lin L; Kang M; Solberg TD; Mertens T; Baeumer C; Ainsley CG; McDonough JE
Proposed linear energy transfer areal detector for protons using radiochromic film.
Rev Sci Instrum Volume: 86 Page(s): 044301
04/01/2015 Authors: Mayer R; Lin L; Fager M; Douglas D; McDonough J; Carabe A
Effects of a granulocyte colony stimulating factor, Neulasta, in mini pigs exposed to total body proton irradiation.
Life Sci Space Res (Amst) Volume: 5 Page(s): 13 - 20
04/01/2015 Authors: Sanzari JK; Krigsfeld GS; Shuman AL; Diener AK; Lin L; Mai W; Kennedy AR
Broad-spectrum antibiotic or G-CSF as potential countermeasures for impaired control of bacterial infection associated with an SPE exposure during spaceflight.
PLoS One Volume: 10 Page(s): e0120126
01/01/2015 Authors: Li M; Holmes V; Ni H; Sanzari JK; Romero-Weaver AL; Lin L; Carabe-Fernandez A; Diffenderfer ES; Kennedy AR; Weissman D
Comparison of changes over time in leukocyte counts in Yucatan minipigs irradiated with simulated solar particle event-like radiation.
Life Sci Space Res (Amst) Volume: 4 Page(s): 11 - 16
01/01/2015 Authors: Sanzari JK; Wan XS; Muehlmatt A; Lin L; Kennedy AR
Experimentally validated pencil beam scanning source model in TOPAS.
Phys Med Biol Volume: 59 Page(s): 6859 - 6873
11/21/2014 Authors: Lin L; Kang M; Solberg TD; Ainsley CG; McDonough JE
Development of a golden beam data set for the commissioning of a proton double-scattering system in a pencil-beam dose calculation algorithm.
Med Phys Volume: 41 Page(s): 091710
09/01/2014 Authors: Slopsema RL; Lin L; Flampouri S; Yeung D; Li Z; McDonough JE; Palta J
Pencil beam scanning dosimetry for large animal irradiation.
J Radiat Res Volume: 55 Page(s): 855 - 861
09/01/2014 Authors: Lin L; Solberg TD; Carabe A; Mcdonough JE; Diffenderfer E; Sanzari JK; Kennedy AR; Cengel K
Development and clinical implementation of a universal bolus to maintain spot size during delivery of base of skull pencil beam scanning proton therapy.
Int J Radiat Oncol Biol Phys Volume: 90 Page(s): 79 - 84
09/01/2014 Authors: Both S; Shen J; Kirk M; Lin L; Tang S; Alonso-Basanta M; Lustig R; Lin H; Deville C; Hill-Kayser C
Orally Administered Fructose Increases the Numbers of Peripheral Lymphocytes Reduced by Exposure of Mice to Gamma or SPE-like Proton Radiation.
Life Sci Space Res (Amst) Volume: 2 Page(s): 80 - 85
07/01/2014 Authors: Romero-Weaver AL; Ni J; Lin L; Kennedy AR
Implementation of an improved dose-per-MU model for double-scattered proton beams to address interbeamline modulation width variability.
J Appl Clin Med Phys Volume: 15 Page(s): 4748
05/08/2014 Authors: Lin L; Shen J; Ainsley CG; Solberg TD; McDonough JE
Evidence for radiation-induced disseminated intravascular coagulation as a major cause of radiation-induced death in ferrets.
Int J Radiat Oncol Biol Phys Volume: 88 Page(s): 940 - 946
03/15/2014 Authors: Krigsfeld GS; Savage AR; Billings PC; Lin L; Kennedy AR
Increased intracranial pressure in mini-pigs exposed to simulated solar particle event radiation.
Acta Astronaut Volume: 94 Page(s): 807 - 812
02/01/2014 Authors: Sanzari J; Muehlmatt A; Savage A; Lin L; Kennedy A
Experimental characterization of two-dimensional spot profiles for two proton pencil beam scanning nozzles.
Phys Med Biol Volume: 59 Page(s): 493 - 504
01/20/2014 Authors: Lin L; Ainsley CG; Solberg TD; McDonough JE
Particle therapy for non-small cell lung tumors: where do we stand? A systematic review of the literature.
Front Oncol Volume: 4 Page(s): 292
01/01/2014 Authors: Wink KCJ; Roelofs E; Solberg T; Lin L; Simone CB; Jakobi A; Richter C; Lambin P; Troost EGC
Discrete-event Based Vehicle Dispatching and Scheduling in Multicommodity Transportations
Page(s): 169 - 174
01/01/2014 Authors: Sami S; Lin L; Shehabinia AR; Su R; Chong CS; Jeon S
Experimental characterization of two-dimensional pencil beam scanning proton spot profiles.
Phys Med Biol Volume: 58 Page(s): 6193 - 6204
09/07/2013 Authors: Lin L; Ainsley CG; McDonough JE
Kinetics of neutrophils in mice exposed to radiation and/or granulocyte colony-stimulating factor treatment.
Radiat Res Volume: 180 Page(s): 177 - 188
08/01/2013 Authors: Romero-Weaver AL; Wan XS; Diffenderfer ES; Lin L; Kennedy AR
A novel technique for measuring the low-dose envelope of pencil-beam scanning spot profiles.
Phys Med Biol Volume: 58 Page(s): N171 - N180
06/21/2013 Authors: Lin L; Ainsley CG; Mertens T; De Wilde O; Talla PT; McDonough JE
Optimization of the modelling of longitudinal dose distributions for double-scattered proton beams in a commercially-available treatment planning system.
Phys Med Biol Volume: 58 Page(s): N145 - N155
06/07/2013 Authors: Ainsley CG; Lin L; McDonough JE
Effect of SPE-like proton or photon radiation on the kinetics of mouse peripheral blood cells and radiation biological effectiveness determinations.
Astrobiology Volume: 13 Page(s): 570 - 577
06/01/2013 Authors: Romero-Weaver AL; Wan XS; Diffenderfer ES; Lin L; Kennedy AR
Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure.
PLoS One Volume: 8 Page(s): e71757
01/01/2013 Authors: Sanzari JK; Romero-Weaver AL; James G; Krigsfeld G; Lin L; Diffenderfer ES; Kennedy AR
Effect of solar particle event radiation and hindlimb suspension on gastrointestinal tract bacterial translocation and immune activation.
PLoS One Volume: 7 Page(s): e44329
01/01/2012 Authors: Zhou Y; Ni H; Li M; Sanzari JK; Diffenderfer ES; Lin L; Kennedy AR; Weissman D
Remarks on the Difficulty of Top-Down Supervisor Synthesis
Page(s): 270 - 275
01/01/2012 Authors: Lin L; Su R; Stefanescu A
Dosimetric uncertainty in prostate cancer proton radiotherapy.
Med Phys Volume: 35 Page(s): 4800 - 4807
11/01/2008 Authors: Lin L; Vargas C; Hsi W; Indelicato D; Slopsema R; Li Z; Yeung D; Horne D; Palta J
Image guidance based on prostate position for prostate cancer proton therapy.
Int J Radiat Oncol Biol Phys Volume: 71 Page(s): 1322 - 1328
08/01/2008 Authors: Vargas C; Wagner M; Indelicato D; Fryer A; Horne D; Chellini A; McKenzie C; Lawlor P; Mahajan C; Li Z
Proton therapy coverage for prostate cancer treatment.
Int J Radiat Oncol Biol Phys Volume: 70 Page(s): 1492 - 1501
04/01/2008 Authors: Vargas C; Wagner M; Mahajan C; Indelicato D; Fryer A; Falchook A; Horne D; Chellini A; McKenzie C; Lawlor P
Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer.
Int J Radiat Oncol Biol Phys Volume: 70 Page(s): 744 - 751
03/01/2008 Authors: Vargas C; Fryer A; Mahajan C; Indelicato D; Horne D; Chellini A; McKenzie C; Lawlor P; Henderson R; Li Z
The use of directional interstitial sources to improve dosimetry in breast brachytherapy.
Med Phys Volume: 35 Page(s): 240 - 247
01/01/2008 Authors: Lin L; Patel RR; Thomadsen BR; Henderson DL

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