John Nickerson PhD
Overview
Dr. Nickerson joined Emory Eye Center in 1991. He currently serves as professor and director of Research. His interests are in retinal degenerative diseases and the genetics behind them. He studies pharmacological and gene therapy approaches to slowing or preventing these degenerations.
Nickerson received his bachelors degree at Massachusetts Institute of Technology, masters degree at Michigan State University, PhD at the University of Texas Medical Branch, and a postdoctoral fellowship at the National Institutes of Health (NIH). He served as a senior fellow and a biologist at the NIH.
Dr. Nickerson's interests are in retinal proteins and their expression in normal animals and in animal models exhibiting characteristics of human eye diseases.
Whether as a treatment in human disease or as a laboratory tool, the delivery of nucleic acids into cells and expression of a gene are important. Many strategies have been proposed, and many, to some degree, function as promised.
Difficulties arise when migrating from a laboratory tool or proof-of-principle into a reasonable and effective therapeutic agent. Viruses and viral particles have been most effective so far, but they have drawbacks. Other approaches have not been as efficient.
The invasiveness of current gene delivery schemes has been secondary to their efficiency and their associated risks, such as immunogenicity. We are considering noninvasive technologies to circumvent many problems with present gene delivery approaches. We employ mouse models of human ocular genetic diseases in testing gene delivery.
Awards and Honors
The Association for Research in Vision and Ophthalmology (ARVO) awarded Nickerson, PhD, the prestigious Gold Fellow status in 2013. Nickerson was tapped an ARVO Silver Fellow in 2009, having served on several ARVO committees and in leadership roles over the years. In 2013 he served as the ARVO Awards Committee chair.
Nickerson is a founding and current editor-in-chief of Molecular Vision, a peer-reviewed journal dedicated to the dissemination of research results in molecular biology, cell biology and the genetics of the visual system. The journal is rated in the top five of a field of 32 competing journals and is routinely used as an open access exemplar by the National Library of Medicine and The National Institutes of Health Library.
He serves on the editorial boards of The Journal of Ocular Biology, Diseases, and Informatics and Clinical Optometry. He is active on numerous national and international committees and has served institutionally as well, at Emory on the Universitys Library Policy Committee. He is a prolific manuscript reviewer for numerous scientific publications.
A sought-after lecturer and visiting professor, Nickerson has been an invited speaker to universities across the United States as well as to international conferences. He has published more than 80 research articles, and numerous book chapters and abstracts.
Academic Appointment
- Professor, Department of Ophthalmology, Emory University
Education
Degrees
- PhD, Human Genetics from University of Texas Medical Branch
- MS, Anatomy from Michigan State University
- BS, Biology from Massachusetts Institute of Technology
Research
Focus
- I study fundamental biological, genetic, and evolutionary principles as reflected in the normal visual system and in the etiology of eye disease. I seek strategies to undertake therapy in eye diseases, as the effectiveness of a rational therapy helps to test our understanding of normal processes and disease states. I use state of the art molecular biology and biochemistry tools in conducting these experiments.
Publications
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Tauroursodeoxycholic Acid Protects Retinal Ganglion Cells and Reduces Inflammation in Mice Following Optic Nerve Crush.
Pharmaceuticals (Basel) Volume: 18
04/14/2025 Authors: Zhang N; Li Y; Zhang X; Chrenek MA; Wang J; Girardot PE; Sellers JT; Geisert EE; Nickerson JM; Boatright JH -
Accessible LED Lightbox for Light-induced Retinal Damage in Pigmented Mice.
Invest Ophthalmol Vis Sci Volume: 66 Page(s): 49
02/03/2025 Authors: Aliff HL; Crockett AB; Chrenek MA; Nickerson JM; Boatright JH; Tseytlin O; Johnson M; Bockius HG; Kuzak SG; Ramamurthy V -
Temporal Regulation of Myopia and Inflammation-Associated Pathways in the Interphotoreceptor Retinoid-Binding Protein Knockout Mouse Model.
Curr Eye Res Volume: 50 Page(s): 221 - 230
02/01/2025 Authors: Markand S; Kim S; Chrenek MA; Ferdous S; Priyadarshani P; Boatright JH; Nickerson JM -
High resolution imaging and interpretation of three-dimensional RPE sheet structure.
01/28/2025 Authors: Donaldson KJ; Chrenek MA; Boatright JH; Nickerson JM -
An improved method of transducing retinal ganglion cells using AAV via transpupillary injection in adult mouse eyes.
Mol Vis Volume: 31 Page(s): 1 - 9
01/01/2025 Authors: Lin F; Lin S-T; Wang J; Sellers JT; Chrenek MA; Nickerson JM; Boatright JH; Geisert EE -
Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage.
12/04/2024 Authors: Shelton DA; Papania JT; Getz TE; Sellers JT; Giradot PE; Chrenek MA; Grossniklaus HE; Boatright JH; Nickerson JM -
Oral supplementation with Nicotinamide Riboside treatment protects RGCs in DBA/2J mouse model.
bioRxiv
12/04/2024 Authors: Zhang N; Li Y; Zhang X; Chrenek MA; Wang J; Girardot PE; Sellers JT; Brenner C; Cui X; Geisert EE -
Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia.
Invest Ophthalmol Vis Sci Volume: 65 Page(s): 32
06/03/2024 Authors: Getz TE; Chrenek MA; Papania JT; Shelton DA; Markand S; Iuvone PM; Kozmik Z; Boatright JH; Nickerson JM -
Voluntary exercise preserves visual function and reduces inflammatory response in an adult mouse model of autosomal dominant retinitis pigmentosa.
Sci Rep Volume: 14 Page(s): 6940
03/23/2024 Authors: Bales KL; Karesh AM; Hogan K; Chacko AS; Douglas GL; Feola AJ; Nickerson JM; Pybus A; Wood L; Boatright JH -
Age-Related RPE changes in Wildtype C57BL/6J Mice between 2 and 32 Months.
bioRxiv
02/01/2024 Authors: Shelton DA; Gefke I; Summers V; Kim Y-K; Yu H; Getz Y; Ferdous S; Donaldson K; Liao K; Papania JT