School of Medicine Homepage
Emory University Shield
  • About
    • Our Vision
    • Academic Departments
    • Our Leadership
    • Health Care Partnerships
    • Diversity, Equity, & Inclusion
    • Location
    • Supporting Our People
    • Our Faculty
    • History
    • News
    • Events
    • Contact Us
  • Education
    • Degree and Certificate Programs
    • Academic Departments
    • Residents & Fellows
    • Postdoctoral Training
    • Continuing Medical Education
    • Admissions
    • Cost and Financial Aid
    • Student Resources
  • Research
    • Research Innovation
    • Conducting Research
    • Core Facilities
    • Research Centers
    • Research Training
    • Academic Departments
    • Find a Researcher
    • Research News
  • Clinical Experience
    • Where We Work
    • Caring for a Diverse Population
    • Faculty Clinical Experience
    • Advanced Patient Care
    • Academic Departments
    • Community Learning
  • Giving
  • Directory

Directory section navigation

  • Faculty Profiles

Emory University School of Medicine

  • About
    • Sub link
      Our Vision
    • Sub link
      Academic Departments
    • Sub link
      Our Leadership
    • Sub link
      Health Care Partnerships
    • Sub link
      Diversity, Equity, & Inclusion
    • Sub link
      Location
    • Sub link
      Supporting Our People
    • Sub link
      Our Faculty
    • Sub link
      History
    • Sub link
      News
    • Sub link
      Events
    • Sub link
      Contact Us
  • Education
    • Sub link
      Degree and Certificate Programs
    • Sub link
      Academic Departments
    • Sub link
      Residents & Fellows
    • Sub link
      Postdoctoral Training
    • Sub link
      Continuing Medical Education
    • Sub link
      Admissions
    • Sub link
      Cost and Financial Aid
    • Sub link
      Student Resources
  • Research
    • Sub link
      Research Innovation
    • Sub link
      Conducting Research
    • Sub link
      Core Facilities
    • Sub link
      Research Centers
    • Sub link
      Research Training
    • Sub link
      Academic Departments
    • Sub link
      Find a Researcher
    • Sub link
      Research News
  • Clinical Experience
    • Sub link
      Where We Work
    • Sub link
      Caring for a Diverse Population
    • Sub link
      Faculty Clinical Experience
    • Sub link
      Advanced Patient Care
    • Sub link
      Academic Departments
    • Sub link
      Community Learning
  • Giving
  • Directory
  • Home School of Medicine Home
  • Directory

Profile

Leonard Howell PhD

  • Department of Psychiatry and Behavioral Sciences
    Professor Emeritus
  • (404) 727-7786
  • lhowell@emory.edu

Research

Publications

  • Alterations in adolescent brain serotonin (5HT)1A, 5HT2A, and dopamine (D)2 receptor systems in a nonhuman primate model of early life adversity.
    Neuropsychopharmacology Volume: 49 Page(s): 1227 - 1235
    07/01/2024 Authors: Wakeford AGP; Nye JA; Morin EL; Mun J; Meyer JS; Goodman M; Howell LL; Sanchez MM
  • Longitudinal evaluation of the functional connectivity changes in the secondary somatosensory cortex (S2) of the monkey brain during acute stroke.
    Curr Res Neurobiol Volume: 5 Page(s): 100097
    01/01/2023 Authors: Li C-X; Tong F; Kempf D; Howell L; Zhang X
  • Investigation of white matter and grey matter alteration in the monkey brain following ischemic stroke by using diffusion tensor imaging.
    Investig Magn Reson Imaging Volume: 26 Page(s): 275 - 283
    12/01/2022 Authors: Li C-X; Meng Y; Yan Y; Kempf D; Howell L; Tong F; Zhang X
  • Influence of Pair-housing on Sleep Parameters Evaluated with Actigraphy in Female Rhesus Monkeys.
    J Am Assoc Lab Anim Sci Volume: 61 Page(s): 165 - 172
    03/01/2022 Authors: Berro LF; Pareek T; Reeves-Darby JA; Andersen ML; Howell LL; Platt DM; Rowlett JK
  • Validation of the Social Responsiveness Scale (SRS) to screen for atypical social behaviors in juvenile macaques.
    PLoS One Volume: 16 Page(s): e0235946
    01/01/2021 Authors: Kovacs Balint Z; Raper J; Michopoulos V; Howell LH; Gunter C; Bachevalier J; Sanchez MM
  • Effects of alfaxalone on cerebral blood flow and intrinsic neural activity of rhesus monkeys: A comparison study with ketamine.
    Magn Reson Imaging Volume: 75 Page(s): 134 - 140
    01/01/2021 Authors: Li C-X; Kempf D; Howell L; Zhang X
  • Effects of early life stress on cocaine intake in male and female rhesus macaques.
    Psychopharmacology (Berl) Volume: 237 Page(s): 3583 - 3589
    12/01/2020 Authors: Wakeford AGP; Kochoian B; Siebert ER; Katznelson S; Morin EL; Howell BR; McCormack KM; Nader MA; Sanchez MM; Howell LL
  • Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series.
    Neurobiol Dis Volume: 144 Page(s): 105027
    10/01/2020 Authors: Joers V; Masilamoni G; Kempf D; Weiss AR; Rotterman TM; Murray B; Yalcin-Cakmakli G; Voll RJ; Goodman MM; Howell L
  • Examining fMRI time-series entropy as a marker for brain E/I balance with pharmacological neuromodulation in a non-human primate translational model.
    Neurosci Lett Volume: 728 Page(s): 134984
    05/29/2020 Authors: Maltbie EA; Howell LH; Sun PZ; Miller R; Gopinath KS
  • Utility of positron emission tomography-computed tomography in patients with chronic lymphocytic leukemia following B-cell receptor pathway inhibitor therapy.
    Haematologica Volume: 104 Page(s): 2258 - 2264
    11/01/2019 Authors: Mato AR; Wierda WG; Davids MS; Cheson BD; Coutre SE; Choi M; Furman RR; Heffner L; Barr PM; Eradat H
  • Effects of early life stress on cocaine self-administration in post-pubertal male and female rhesus macaques.
    Psychopharmacology (Berl) Volume: 236 Page(s): 2785 - 2796
    09/01/2019 Authors: Wakeford AGP; Morin EL; Bramlett SN; Howell BR; McCormack KM; Meyer JS; Nader MA; Sanchez MM; Howell LL
  • Effects of ketamine treatment on cocaine-induced reinstatement and disruption of functional connectivity in unanesthetized rhesus monkeys.
    Psychopharmacology (Berl) Volume: 236 Page(s): 2105 - 2118
    07/01/2019 Authors: Maltbie EA; Gopinath KS; Howell LL
  • Sensitization to the prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA).
    Neuropharmacology Volume: 151 Page(s): 13 - 20
    06/01/2019 Authors: Curry DW; Berro LF; Belkoff AR; Sulima A; Rice KC; Howell LL
  • Effects of long-term high-fat food or methamphetamine intake and serotonin 2C receptors on reversal learning in female rhesus macaques.
    Neuropsychopharmacology Volume: 44 Page(s): 478 - 486
    02/01/2019 Authors: Perez Diaz M; Wilson ME; Howell LL
  • Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys.
    Drug Alcohol Depend Volume: 194 Page(s): 252 - 256
    01/01/2019 Authors: Odabas-Geldiay M; Shields H; Berro LF; Rice KC; Howell LL
  • Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Macaca mulatta) with Seizures.
    Comp Med Volume: 68 Page(s): 496 - 502
    12/01/2018 Authors: Li C-X; Kempf DJ; Tong FC; Yan Y; Xu Z; Connor-Stroud FR; Ford BD; Howell LL; Zhang X
  • A review of nonhuman primate models of early life stress and adolescent drug abuse.
    Neurobiol Stress Volume: 9 Page(s): 188 - 198
    11/01/2018 Authors: Wakeford AGP; Morin EL; Bramlett SN; Howell LL; Sanchez MM
  • A peripheral immune response to remembering trauma contributes to the maintenance of fear memory in mice.
    Psychoneuroendocrinology Volume: 94 Page(s): 143 - 151
    08/01/2018 Authors: Young MB; Howell LL; Hopkins L; Moshfegh C; Yu Z; Clubb L; Seidenberg J; Park J; Swiercz AP; Marvar PJ
  • Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) and R(-) MDMA on actigraphy-based daytime activity and sleep parameters in rhesus monkeys.
    Exp Clin Psychopharmacol Volume: 26 Page(s): 410 - 420
    08/01/2018 Authors: Berro LF; Shields H; Odabas-Geldiay M; Rothbaum BO; Andersen ML; Howell LL
  • Synthesis and Evaluation of Pyridyloxypyridyl Indole Carboxamides as Potential PET Imaging Agents for 5-HT2C Receptors.
    ACS Med Chem Lett Volume: 9 Page(s): 188 - 192
    03/08/2018 Authors: Zeng F; Nye JA; Voll RJ; Howell L; Goodman MM
  • ()-MDMA and its enantiomers: potential therapeutic advantages of R(-)-MDMA.
    Psychopharmacology (Berl) Volume: 235 Page(s): 377 - 392
    02/01/2018 Authors: Pitts EG; Curry DW; Hampshire KN; Young MB; Howell LL
  • Separating the agony from ecstasy: R(-)-3,4-methylenedioxymethamphetamine has prosocial and therapeutic-like effects without signs of neurotoxicity in mice.
    Neuropharmacology Volume: 128 Page(s): 196 - 206
    01/01/2018 Authors: Curry DW; Young MB; Tran AN; Daoud GE; Howell LL
  • Progressive Assessment of Ischemic Injury to White Matter Using Diffusion Tensor Imaging: A Preliminary Study of a Macaque Model of Stroke.
    Open Neuroimag J Volume: 12 Page(s): 30 - 41
    01/01/2018 Authors: Zhang X; Yan Y; Tong F; Li C-X; Jones B; Wang S; Meng Y; Muly EC; Kempf D; Howell L
  • Ketamine and pharmacological imaging: use of functional magnetic resonance imaging to evaluate mechanisms of action.
    Behav Pharmacol Volume: 28 Page(s): 610 - 622
    12/01/2017 Authors: Maltbie EA; Kaundinya GS; Howell LL
  • Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA).
    Psychopharmacology (Berl) Volume: 234 Page(s): 2883 - 2895
    10/01/2017 Authors: Young MB; Norrholm SD; Khoury LM; Jovanovic T; Rauch SAM; Reiff CM; Dunlop BW; Rothbaum BO; Howell LL
  • GABAA receptor positive allosteric modulators modify the abuse-related behavioral and neurochemical effects of methamphetamine in rhesus monkeys.
    Neuropharmacology Volume: 123 Page(s): 299 - 309
    09/01/2017 Authors: Berro LF; Andersen ML; Tufik S; Howell LL
  • Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 234 Page(s): 2607 - 2617
    09/01/2017 Authors: Berro LF; Perez Diaz M; Maltbie E; Howell LL
  • 3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner.
    Neuropsychopharmacology Volume: 42 Page(s): 1962 - 1971
    09/01/2017 Authors: Pitts EG; Minerva AR; Chandler EB; Kohn JN; Logun MT; Sulima A; Rice KC; Howell LL
  • Assessment of tolerance to the effects of methamphetamine on daytime and nighttime activity evaluated with actigraphy in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 234 Page(s): 2277 - 2287
    08/01/2017 Authors: Berro LF; Andersen ML; Howell LL
  • Metabolism and Distribution of Clozapine-N-oxide: Implications for Nonhuman Primate Chemogenetics.
    ACS Chem Neurosci Volume: 8 Page(s): 1570 - 1576
    07/19/2017 Authors: Raper J; Morrison RD; Daniels JS; Howell L; Bachevalier J; Wichmann T; Galvan A
  • Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys.
    Neuropsychopharmacology Volume: 42 Page(s): 1531 - 1538
    06/01/2017 Authors: Perez Diaz M; Andersen ML; Rice KC; Howell LL
  • Ketamine-induced changes in connectivity of functional brain networks in awake female nonhuman primates: a translational functional imaging model.
    Psychopharmacology (Berl) Volume: 233 Page(s): 3673 - 3684
    10/01/2016 Authors: Gopinath K; Maltbie E; Urushino N; Kempf D; Howell L
  • Actigraphy-based sleep parameters during the reinstatement of methamphetamine self-administration in rhesus monkeys.
    Exp Clin Psychopharmacol Volume: 24 Page(s): 142 - 146
    04/01/2016 Authors: Berro LF; Andersen ML; Tufik S; Howell LL
  • Ketamine-induced brain activation in awake female nonhuman primates: a translational functional imaging model.
    Psychopharmacology (Berl) Volume: 233 Page(s): 961 - 972
    03/01/2016 Authors: Maltbie E; Gopinath K; Urushino N; Kempf D; Howell L
  • An Enhanced Model of Middle Cerebral Artery Occlusion in Nonhuman Primates Using an Endovascular Trapping Technique.
    AJNR Am J Neuroradiol Volume: 36 Page(s): 2354 - 2359
    12/01/2015 Authors: Tong FC; Zhang X; Kempf DJ; Yepes MS; Connor-Stroud FR; Zola S; Howell L
  • 3,4-Methylenedioxymethamphetamine facilitates fear extinction learning.
    Transl Psychiatry Volume: 5 Page(s): e634
    09/15/2015 Authors: Young MB; Andero R; Ressler KJ; Howell LL
  • Proton resonance frequency chemical shift thermometry: experimental design and validation toward high-resolution noninvasive temperature monitoring and in vivo experience in a nonhuman primate model of acute ischemic stroke.
    AJNR Am J Neuroradiol Volume: 36 Page(s): 1128 - 1135
    06/01/2015 Authors: Dehkharghani S; Mao H; Howell L; Zhang X; Pate KS; Magrath PR; Tong F; Wei L; Qiu D; Fleischer C
  • Functional connectivity in frontal-striatal brain networks and cocaine self-administration in female rhesus monkeys.
    Psychopharmacology (Berl) Volume: 232 Page(s): 745 - 754
    02/01/2015 Authors: Murnane KS; Gopinath KS; Maltbie E; Daunais JB; Telesford QK; Howell LL
  • Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder.
    Pharmacol Rev Volume: 67 Page(s): 176 - 197
    01/01/2015 Authors: Howell LL; Cunningham KA
  • Temporal evolution of ischemic lesions in nonhuman primates: a diffusion and perfusion MRI study.
    PLoS One Volume: 10 Page(s): e0117290
    01/01/2015 Authors: Zhang X; Tong F; Li C-X; Yan Y; Kempf D; Nair G; Wang S; Muly EC; Zola S; Howell L
  • Effects of pharmacologic dopamine -hydroxylase inhibition on cocaine-induced reinstatement and dopamine neurochemistry in squirrel monkeys.
    J Pharmacol Exp Ther Volume: 350 Page(s): 144 - 152
    07/01/2014 Authors: Cooper DA; Kimmel HL; Manvich DF; Schmidt KT; Weinshenker D; Howell LL
  • A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates.
    Transl Psychiatry Volume: 4 Page(s): e407
    07/01/2014 Authors: Howell LL; Nye JA; Stehouwer JS; Voll RJ; Mun J; Narasimhan D; Nichols J; Sunahara R; Goodman MM; Carroll FI
  • A fast multiparameter MRI approach for acute stroke assessment on a 3T clinical scanner: preliminary results in a non-human primate model with transient ischemic occlusion.
    Quant Imaging Med Surg Volume: 4 Page(s): 112 - 122
    04/01/2014 Authors: Zhang X; Tong F; Li C-X; Yan Y; Nair G; Nagaoka T; Tanaka Y; Zola S; Howell L
  • Monoamine transporter inhibitors and substrates as treatments for stimulant abuse.
    Adv Pharmacol Volume: 69 Page(s): 129 - 176
    01/01/2014 Authors: Howell LL; Negus SS
  • Selective serotonin 2A receptor antagonism attenuates the effects of amphetamine on arousal and dopamine overflow in non-human primates.
    J Sleep Res Volume: 22 Page(s): 581 - 588
    10/01/2013 Authors: Murnane KS; Andersen ML; Rice KC; Howell LL
  • Chronic interferon- decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates.
    Neuropsychopharmacology Volume: 38 Page(s): 2179 - 2187
    10/01/2013 Authors: Felger JC; Mun J; Kimmel HL; Nye JA; Drake DF; Hernandez CR; Freeman AA; Rye DB; Goodman MM; Howell LL
  • Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates.
    J Neurosci Volume: 33 Page(s): 13367 - 13374
    08/14/2013 Authors: Murnane KS; Winschel J; Schmidt KT; Stewart LM; Rose SJ; Cheng K; Rice KC; Howell LL
  • Reply to Dr. Kawada's letter.
    Psychopharmacology (Berl) Volume: 228 Page(s): 511
    08/01/2013 Authors: Howell L
  • Effects of methamphetamine self-administration on actigraphy-based sleep parameters in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 227 Page(s): 101 - 107
    05/01/2013 Authors: Andersen ML; Diaz MP; Murnane KS; Howell LL
  • Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor.
    Nat Commun Volume: 4 Page(s): 1955
    01/01/2013 Authors: Chen J; Repunte-Canonigo V; Kawamura T; Lefebvre C; Shin W; Howell LL; Hemby SE; Harvey BK; Califano A; Morales M
  • Dopaminergic dysregulation in prefrontal cortex of rhesus monkeys following cocaine self-administration.
    Front Psychiatry Volume: 4 Page(s): 88
    01/01/2013 Authors: McIntosh S; Howell L; Hemby SE
  • The serotonin 2C receptor antagonist SB 242084 exhibits abuse-related effects typical of stimulants in squirrel monkeys.
    J Pharmacol Exp Ther Volume: 342 Page(s): 761 - 769
    09/01/2012 Authors: Manvich DF; Kimmel HL; Cooper DA; Howell LL
  • Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.
    Neuropsychopharmacology Volume: 37 Page(s): 1816 - 1824
    07/01/2012 Authors: Sawyer EK; Mun J; Nye JA; Kimmel HL; Voll RJ; Stehouwer JS; Rice KC; Goodman MM; Howell LL
  • Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys.
    Synapse Volume: 66 Page(s): 501 - 508
    06/01/2012 Authors: Kimmel HL; Nye JA; Voll R; Mun J; Stehouwer J; Goodman MM; Votaw JR; Carroll FI; Howell LL
  • Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys.
    J Pharmacol Exp Ther Volume: 341 Page(s): 424 - 434
    05/01/2012 Authors: Manvich DF; Kimmel HL; Howell LL
  • Influence of chronic dopamine transporter inhibition by RTI-336 on motor behavior, sleep, and hormone levels in rhesus monkeys.
    Exp Clin Psychopharmacol Volume: 20 Page(s): 77 - 83
    04/01/2012 Authors: Andersen ML; Sawyer EK; Carroll FI; Howell LL
  • Effects of exposure to amphetamine derivatives on passive avoidance performance and the central levels of monoamines and their metabolites in mice: correlations between behavior and neurochemistry.
    Psychopharmacology (Berl) Volume: 220 Page(s): 495 - 508
    04/01/2012 Authors: Murnane KS; Perrine SA; Finton BJ; Galloway MP; Howell LL; Fantegrossi WE
  • The cystine-glutamate transporter enhancer N-acetyl-L-cysteine attenuates cocaine-induced changes in striatal dopamine but not self-administration in squirrel monkeys.
    Pharmacol Biochem Behav Volume: 101 Page(s): 288 - 296
    04/01/2012 Authors: Bauzo RM; Kimmel HL; Howell LL
  • Relationship between dose, drug levels, and D2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone.
    J Pharmacol Exp Ther Volume: 341 Page(s): 81 - 89
    04/01/2012 Authors: Muly EC; Votaw JR; Ritchie J; Howell LL
  • The neuropharmacology of prolactin secretion elicited by 3,4-methylenedioxymethamphetamine ("ecstasy"): a concurrent microdialysis and plasma analysis study.
    Horm Behav Volume: 61 Page(s): 181 - 190
    02/01/2012 Authors: Murnane KS; Kimmel HL; Rice KC; Howell LL
  • Contributions of neuroimaging to understanding sex differences in cocaine abuse.
    Exp Clin Psychopharmacol Volume: 20 Page(s): 2 - 15
    02/01/2012 Authors: Andersen ML; Sawyer EK; Howell LL
  • Neuroimaging and drug taking in primates.
    Psychopharmacology (Berl) Volume: 216 Page(s): 153 - 171
    07/01/2011 Authors: Murnane KS; Howell LL
  • Nonhuman primate positron emission tomography neuroimaging in drug abuse research.
    J Pharmacol Exp Ther Volume: 337 Page(s): 324 - 334
    05/01/2011 Authors: Howell LL; Murnane KS
  • Pharmacokinetics of fluoxetine in rhesus macaques following multiple routes of administration.
    Pharmacology Volume: 88 Page(s): 44 - 49
    01/01/2011 Authors: Sawyer EK; Howell LL
  • (18)F-FECNT: validation as PET dopamine transporter ligand in parkinsonism.
    Exp Neurol Volume: 226 Page(s): 265 - 273
    12/01/2010 Authors: Masilamoni G; Votaw J; Howell L; Villalba RM; Goodman M; Voll RJ; Stehouwer J; Wichmann T; Smith Y
  • Acute brain metabolic effects of cocaine in rhesus monkeys with a history of cocaine use.
    Brain Imaging Behav Volume: 4 Page(s): 212 - 219
    12/01/2010 Authors: Henry PK; Murnane KS; Votaw JR; Howell LL
  • Development of an apparatus and methodology for conducting functional magnetic resonance imaging (fMRI) with pharmacological stimuli in conscious rhesus monkeys.
    J Neurosci Methods Volume: 191 Page(s): 11 - 20
    08/15/2010 Authors: Murnane KS; Howell LL
  • Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.
    J Med Chem Volume: 53 Page(s): 5549 - 5557
    08/12/2010 Authors: Stehouwer JS; Daniel LM; Chen P; Voll RJ; Williams L; Plott SJ; Votaw JR; Owens MJ; Howell L; Goodman MM
  • Endocrine and neurochemical effects of 3,4-methylenedioxymethamphetamine and its stereoisomers in rhesus monkeys.
    J Pharmacol Exp Ther Volume: 334 Page(s): 642 - 650
    08/01/2010 Authors: Murnane KS; Fantegrossi WE; Godfrey JR; Banks ML; Howell LL
  • Dopamine transporter-related effects of modafinil in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 210 Page(s): 439 - 448
    06/01/2010 Authors: Andersen ML; Kessler E; Murnane KS; McClung JC; Tufik S; Howell LL
  • Reinstatement of extinguished amphetamine self-administration by 3,4-methylenedioxymethamphetamine (MDMA) and its enantiomers in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 210 Page(s): 75 - 83
    05/01/2010 Authors: McClung J; Fantegrossi W; Howell LL
  • Integrative proteomic analysis of the nucleus accumbens in rhesus monkeys following cocaine self-administration.
    Mol Psychiatry Volume: 15 Page(s): 185 - 203
    02/01/2010 Authors: Tannu NS; Howell LL; Hemby SE
  • Impact of early life stress on the reinforcing and behavioral-stimulant effects of psychostimulants in rhesus monkeys.
    Behav Pharmacol Volume: 21 Page(s): 69 - 76
    02/01/2010 Authors: Ewing Corcoran SB; Howell LL
  • Cortical activation during cocaine use and extinction in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 208 Page(s): 191 - 199
    02/01/2010 Authors: Howell LL; Votaw JR; Goodman MM; Lindsey KP
  • Behavioral and neurochemical effects of amphetamine analogs that release monoamines in the squirrel monkey.
    Pharmacol Biochem Behav Volume: 94 Page(s): 278 - 284
    12/01/2009 Authors: Kimmel HL; Manvich DF; Blough BE; Negus SS; Howell LL
  • Discriminative stimulus effects of psychostimulants and hallucinogens in S(+)-3,4-methylenedioxymethamphetamine (MDMA) and R(-)-MDMA trained mice.
    J Pharmacol Exp Ther Volume: 331 Page(s): 717 - 723
    11/01/2009 Authors: Murnane KS; Murai N; Howell LL; Fantegrossi WE
  • Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys.
    Pharmacol Biochem Behav Volume: 94 Page(s): 204 - 210
    11/01/2009 Authors: Bauzo RM; Kimmel HL; Howell LL
  • Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 205 Page(s): 467 - 474
    08/01/2009 Authors: Banks ML; Andersen ML; Murnane KS; Meyer RC; Howell LL
  • Effects of cocaine self-administration history under limited and extended access conditions on in vivo striatal dopamine neurochemistry and acoustic startle in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 205 Page(s): 237 - 247
    08/01/2009 Authors: Kirkland Henry P; Davis M; Howell LL
  • Role of dopamine transporters in the behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA) in nonhuman primates.
    Psychopharmacology (Berl) Volume: 205 Page(s): 337 - 347
    08/01/2009 Authors: Fantegrossi WE; Bauzo RM; Manvich DM; Morales JC; Votaw JR; Goodman MM; Howell LL
  • Cocaine-induced reinstatement during limited and extended drug access conditions in rhesus monkeys.
    Psychopharmacology (Berl) Volume: 204 Page(s): 523 - 529
    06/01/2009 Authors: Henry PK; Howell LL
  • Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter.
    J Med Chem Volume: 52 Page(s): 62 - 73
    01/08/2009 Authors: Zeng F; Mun J; Jarkas N; Stehouwer JS; Voll RJ; Tamagnan GD; Howell L; Votaw JR; Kilts CD; Nemeroff CB
  • Effects of histamine H(3) receptor activation on the behavioral-stimulant effects of methamphetamine and cocaine in mice and squirrel monkeys.
    Pharmacology Volume: 83 Page(s): 164 - 169
    01/01/2009 Authors: Banks ML; Manvich DF; Bauzo RM; Howell LL
  • Effects of the monoamine uptake inhibitors RTI-112 and RTI-113 on cocaine- and food-maintained responding in rhesus monkeys.
    Pharmacol Biochem Behav Volume: 91 Page(s): 333 - 338
    01/01/2009 Authors: Negus SS; Mello NK; Kimmel HL; Howell LL; Carroll FI
  • Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography.
    J Med Chem Volume: 51 Page(s): 7788 - 7799
    12/25/2008 Authors: Stehouwer JS; Jarkas N; Zeng F; Voll RJ; Williams L; Camp VM; Malveaux EJ; Votaw JR; Howell L; Owens MJ
  • Nonhuman primate neuroimaging and cocaine medication development.
    Exp Clin Psychopharmacol Volume: 16 Page(s): 446 - 457
    12/01/2008 Authors: Howell LL
  • Nonhuman primate neuroimaging and the neurobiology of psychostimulant addiction.
    Volume: 1141 Page(s): 176 - 194
    10/01/2008 Authors: Howell LL; Murnane KS
  • Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys.
    Pharmacol Biochem Behav Volume: 90 Page(s): 453 - 462
    09/01/2008 Authors: Kimmel HL; Negus SS; Wilcox KM; Ewing SB; Stehouwer J; Goodman MM; Votaw JR; Mello NK; Carroll FI; Howell LL
  • Monoamine transporters and psychostimulant addiction.
    Biochem Pharmacol Volume: 75 Page(s): 196 - 217
    01/01/2008 Authors: Howell LL; Kimmel HL
  • Synthesis and in vivo evaluation of fluorine-18 and iodine-123 labeled 2beta-carbo(2-fluoroethoxy)-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane as a candidate serotonin transporter imaging agent.
    J Med Chem Volume: 50 Page(s): 4553 - 4560
    09/20/2007 Authors: Plisson C; Stehouwer JS; Voll RJ; Howell L; Votaw JR; Owens MJ; Goodman MM
  • Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys.
    J Pharmacol Exp Ther Volume: 320 Page(s): 757 - 765
    02/01/2007 Authors: Howell LL; Carroll FI; Votaw JR; Goodman MM; Kimmel HL
  • Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys.
    Pharmacol Biochem Behav Volume: 86 Page(s): 45 - 54
    01/01/2007 Authors: Kimmel HL; O'Connor JA; Carroll FI; Howell LL
  • Development of the dopamine transporter selective RTI-336 as a pharmacotherapy for cocaine abuse.
    AAPS J Volume: 8 Page(s): E196 - E203
    03/24/2006 Authors: Carroll FI; Howard JL; Howell LL; Fox BS; Kuhar MJ
  • Olanzapine-induced suppression of cocaine self-administration in rhesus monkeys.
    Neuropsychopharmacology Volume: 31 Page(s): 585 - 593
    03/01/2006 Authors: Howell LL; Wilcox KM; Lindsey KP; Kimmel HL
  • Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.
    J Med Chem Volume: 49 Page(s): 942 - 946
    02/09/2006 Authors: Plisson C; Jarkas N; McConathy J; Voll RJ; Votaw J; Williams L; Howell LL; Kilts CD; Goodman MM
  • In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys.
    Synapse Volume: 58 Page(s): 220 - 228
    12/15/2005 Authors: Wilcox KM; Kimmel HL; Lindsey KP; Votaw JR; Goodman MM; Howell LL
  • Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates.
    J Neurochem Volume: 95 Page(s): 1785 - 1793
    12/01/2005 Authors: Hemby SE; Tang W; Muly EC; Kuhar MJ; Howell L; Mash DC
  • Changes in extracellular dopamine during cocaine self-administration in squirrel monkeys.
    Synapse Volume: 56 Page(s): 129 - 134
    06/01/2005 Authors: Kimmel HL; Ginsburg BC; Howell LL
  • Synthesis and monoamine transporter binding properties of 3beta-(3',4'-disubstituted phenyl)tropane-2beta-carboxylic acid methyl esters.
    J Med Chem Volume: 48 Page(s): 2767 - 2771
    04/21/2005 Authors: Carroll FI; Blough BE; Nie Z; Kuhar MJ; Howell LL; Navarro HA
  • Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys.
    Pharmacol Biochem Behav Volume: 80 Page(s): 481 - 491
    03/01/2005 Authors: Ginsburg BC; Kimmel HL; Carroll FI; Goodman MM; Howell LL
  • Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging.
    J Pharmacol Exp Ther Volume: 309 Page(s): 959 - 969
    06/01/2004 Authors: Lindsey KP; Wilcox KM; Votaw JR; Goodman MM; Plisson C; Carroll FI; Rice KC; Howell LL
  • Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography.
    J Med Chem Volume: 46 Page(s): 925 - 935
    03/13/2003 Authors: Goodman MM; Chen P; Plisson C; Martarello L; Galt J; Votaw JR; Kilts CD; Malveaux G; Camp VM; Shi B
  • Functional imaging and neurochemical correlates of stimulant self-administration in primates.
    Psychopharmacology (Berl) Volume: 163 Page(s): 352 - 361
    10/01/2002 Authors: Howell LL; Wilcox KM
  • Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT.
    Synapse Volume: 44 Page(s): 203 - 210
    06/15/2002 Authors: Votaw JR; Howell LL; Martarello L; Hoffman JM; Kilts CD; Lindsey KP; Goodman MM
  • Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys.
    J Pharmacol Exp Ther Volume: 300 Page(s): 831 - 837
    03/01/2002 Authors: Czoty PW; Ginsburg BC; Howell LL
  • Self-administration of cocaine and the cocaine analog RTI-113: relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys.
    Synapse Volume: 43 Page(s): 78 - 85
    01/01/2002 Authors: Wilcox KM; Lindsey KP; Votaw JR; Goodman MM; Martarello L; Carroll FI; Howell LL
  • Cocaine-induced brain activation determined by positron emission tomography neuroimaging in conscious rhesus monkeys.
    Psychopharmacology (Berl) Volume: 159 Page(s): 154 - 160
    01/01/2002 Authors: Howell LL; Hoffman JM; Votaw JR; Landrum AM; Wilcox KM; Lindsey KP
  • The dopamine transporter and cocaine medication development: drug self-administration in nonhuman primates.
    J Pharmacol Exp Ther Volume: 298 Page(s): 1 - 6
    07/01/2001 Authors: Howell LL; Wilcox KM
  • An apparatus and behavioral training protocol to conduct positron emission tomography (PET) neuroimaging in conscious rhesus monkeys.
    J Neurosci Methods Volume: 106 Page(s): 161 - 169
    04/30/2001 Authors: Howell LL; Hoffman JM; Votaw JR; Landrum AM; Jordan JF
  • Fetal development in rhesus monkeys exposed prenatally to cocaine.
    Neurotoxicol Teratol Volume: 23 Page(s): 133 - 140
    01/01/2001 Authors: Howell LL; Schama KF; Ellis JE; Grimley PJ; Kitchens AJ; Byrd LD
  • Behavioral effects of AMI-193, a 5-HT(2A)- and dopamine D(2)-receptor antagonist, in the squirrel monkey.
    Pharmacol Biochem Behav Volume: 67 Page(s): 257 - 264
    10/01/2000 Authors: Czoty PW; Howell LL
  • Comparative behavioral pharmacology of cocaine and the selective dopamine uptake inhibitor RTI-113 in the squirrel monkey.
    J Pharmacol Exp Ther Volume: 292 Page(s): 521 - 529
    02/01/2000 Authors: Howell LL; Czoty PW; Kuhar MJ; Carrol FI
  • Cocaine-induced changes in extracellular dopamine determined by microdialysis in awake squirrel monkeys.
    Psychopharmacology (Berl) Volume: 148 Page(s): 299 - 306
    02/01/2000 Authors: Czoty PW; Justice JB; Howell LL
  • Behavioral evaluation of hemiparkinsonian MPTP monkeys following dopamine pharmacological manipulation and adrenal co-graft transplantation.
    Cell Transplant Volume: 9 Page(s): 609 - 622
    01/01/2000 Authors: Howel LL; Byrd LD; McDonough AM; Iuvone PM; Bakay RA
  • Pharmacotherapies for treatment of cocaine abuse: preclinical aspects.
    J Med Chem Volume: 42 Page(s): 2721 - 2736
    07/29/1999 Authors: Carroll FI; Howell LL; Kuhar MJ
  • Effects of chronic caffeine administration on respiration and schedule-controlled behavior in rhesus monkeys.
    J Pharmacol Exp Ther Volume: 283 Page(s): 190 - 199
    10/01/1997 Authors: Howell LL; Landrum AM
  • Serotonergic modulation of the discriminative-stimulus effects of cocaine in squirrel monkeys.
    Psychopharmacology (Berl) Volume: 132 Page(s): 27 - 34
    07/01/1997 Authors: Schama KF; Howell LL; Byrd LD
  • Pharmacological interactions between serotonin and dopamine on behavior in the squirrel monkey.
    Psychopharmacology (Berl) Volume: 131 Page(s): 40 - 48
    05/01/1997 Authors: Howell LL; Czoty PW; Byrd LD
  • Behavioral and physiological effects of xanthines in nonhuman primates.
    Psychopharmacology (Berl) Volume: 129 Page(s): 1 - 14
    01/01/1997 Authors: Howell LL; Coffin VL; Spealman RD
  • Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey.
    J Pharmacol Exp Ther Volume: 275 Page(s): 1551 - 1559
    12/01/1995 Authors: Howell LL; Byrd LD
  • Effects of caffeine on ventilation during acute and chronic nicotine administration in rhesus monkeys.
    J Pharmacol Exp Ther Volume: 273 Page(s): 1085 - 1094
    06/01/1995 Authors: Howell LL
  • Attenuation of hypoxia-induced increases in ventilation by adenosine antagonists in rhesus monkeys.
    Life Sci Volume: 57 Page(s): 773 - 783
    01/01/1995 Authors: Howell LL; Landrum AM
  • Behavioral and pharmacological modulation of respiration in rhesus monkeys.
    J Exp Anal Behav Volume: 62 Page(s): 57 - 72
    07/01/1994 Authors: Howell LL; Landrum AM
  • Effects of CGS 15943, a nonxanthine adenosine antagonist, on behavior in the squirrel monkey.
    J Pharmacol Exp Ther Volume: 267 Page(s): 432 - 439
    10/01/1993 Authors: Howell LL; Byrd LD
  • Comparative effects of caffeine and selective phosphodiesterase inhibitors on respiration and behavior in rhesus monkeys.
    J Pharmacol Exp Ther Volume: 266 Page(s): 894 - 903
    08/01/1993 Authors: Howell LL
  • Effects of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys.
    J Pharmacol Exp Ther Volume: 265 Page(s): 971 - 978
    05/01/1993 Authors: Howell LL
  • Enhanced sensitivity to the behavioral effects of cocaine after chronic administration of D2-selective dopamine antagonists in the squirrel monkey.
    J Pharmacol Exp Ther Volume: 262 Page(s): 907 - 915
    09/01/1992 Authors: Howell LL; Byrd LD
  • Characterization of the effects of cocaine and GBR 12909, a dopamine uptake inhibitor, on behavior in the squirrel monkey.
    J Pharmacol Exp Ther Volume: 258 Page(s): 178 - 185
    07/01/1991 Authors: Howell LL; Byrd LD
  • Respiratory effects of xanthines and adenosine analogs in rhesus monkeys.
    J Pharmacol Exp Ther Volume: 254 Page(s): 786 - 791
    09/01/1990 Authors: Howell LL; Morse WH; Spealman RD
  • Behavioral effects of chronically administered cocaine in squirrel monkeys.
    Psychopharmacology (Berl) Volume: 97 Page(s): 12 - 16
    01/01/1989 Authors: Howell LL; Morse WH
  • Differential effects of cocaine and pentobarbital on fixed-interval and random-interval performance.
    J Exp Anal Behav Volume: 49 Page(s): 411 - 428
    05/01/1988 Authors: Howell LL; Byrd LD; Marr MJ
  • Effects of levorphanol and several kappa-selective opioids on respiration and behavior in rhesus monkeys.
    J Pharmacol Exp Ther Volume: 245 Page(s): 364 - 372
    04/01/1988 Authors: Howell LL; Bergman J; Morse WH
  • Behavioral effects of phencyclidine and ketamine alone and in combination with other drugs.
    Eur J Pharmacol Volume: 144 Page(s): 331 - 341
    12/15/1987 Authors: Byrd LD; Standish LJ; Howell LL
  • Similarities in the rate-altering effects of white noise and cocaine.
    J Exp Anal Behav Volume: 46 Page(s): 381 - 394
    11/01/1986 Authors: Howell LL; Byrd LD; Marr MJ
Read more publications Fewer publications
Directory
  • Faculty Profiles
Emory University Homepage

Contact & Location

Emory University School of Medicine
100 Woodruff Circle
Atlanta, GA  30322 USA
  • Contact Us
  • Maps & Directions
  • Careers

Information For

  • Alumni
  • Faculty & Staff
  • Patients
  • Residents & Fellows
  • Students
Support the School of Medicine School of Medicine Intranet
facebook facebook twitter twitter linkedin linkedin instagram instagram youtube youtube
© 2025 Emory University
  • Privacy Policy
  • Emergency Information
  • EEO Employer-Disability/Veteran Statements