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Profile

Laura Hansen

  • Department of Medicine
    Assistant Professor
  • laura.hansen2@emory.edu
Head shot of Laura Hansen

Overview

Dr. Hansens lab studies the interactions between satellite cells and the vasculature. Satellite cells are skeletal muscle progenitor cells that are known to play an important role in muscle repair after injury and adaptation to exercise. However, the Hansen lab focuses on a previously underexplored role of satellite cells in vascular growth. They have found that satellite cells, when activated, produced a number of chemoattractant growth factors that drive the migration of vascular smooth muscle and endothelial cells which in an important factor in the growth and development of blood vessels. This area is of particular interest in the context of peripheral artery disease, where patients suffer from ischemic tissue damage but treatment options are still limited. The lab has shown that ischemia stimulates satellite cells and are exploring ways to harness their angiogenic properties in vivo or through therapeutically delivered cells.
Dr. Hansen received her BS in Bioengineering from the University of Pittsburgh in 2007 and PhD in Bioengineering from the Georgia Institute of Technology in 2012. She then completed her post-doctoral fellowship at Emory University in Cardiology. She is currently an Assistant Professor in the Department of Medicine and Division of Cardiology and recently received a Career Development Award from the American Heart Association.

Academic Appointment

  • Associate Program Director, Academic Basic Scientist Research Pathway, Emory University
  • Program Faculty BioEngineering, Georgia Institute of Technology
  • Program Faculty Molecular Systems and Pharmacology Graduate Program, Emory University
  • Program Faculty Biomedical Engineering, Emory University/Georgia Institute of Technology
  • Assistant Professor of Medicine, Emory University

Education

Degrees

  • PhD from Georgia Institute of Technology
  • BS from University of Pittsburgh

Research

Publications

  • Is Laser Doppler Perfusion Imaging Trulya "Gold Standard" for Preclinical Peripheral Artery Disease Research?
    JACC Basic Transl Sci Volume: 10 Page(s): 104 - 106
    01/01/2025 Authors: Oh DG; Hansen L; Taylor WR
  • Increasing nitric oxide bioavailability fails to improve collateral vessel formation in humanized sickle cell mice.
    Lab Invest Volume: 102 Page(s): 805 - 813
    08/01/2022 Authors: Lewis CV; Sellak H; Hansen L; Joseph G; Hurtado J; Archer DR; Jun H-W; Brown LA; Taylor WR
  • Satellite Cell Expression of RAGE (Receptor for Advanced Glycation end Products) Is Important for Collateral Vessel Formation.
    J Am Heart Assoc Volume: 10 Page(s): e022127
    11/02/2021 Authors: Hansen L; Joseph G; Valdivia A; Taylor WR
  • Optimization of Oxygen Delivery Within Hydrogels.
    J Biomech Eng Volume: 143
    10/01/2021 Authors: Mavris SM; Hansen LM
  • A Hydrogel Strategy to Augment Tissue Adenosine to Improve Hindlimb Perfusion.
    Arterioscler Thromb Vasc Biol Volume: 41 Page(s): e314 - e324
    06/01/2021 Authors: Sayegh MN; Cooney KA; Han WM; Wang L; Strobel F; Hansen LM; Garca AJ; Levit RD
  • Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit, Myonuclear-, and Mitochondrial-Domains.
    Sci Rep Volume: 9 Page(s): 9551
    07/02/2019 Authors: Mohiuddin M; Lee NH; Moon JY; Han WM; Anderson SE; Choi JJ; Shin E; Nakhai SA; Tran T; Aliya B
  • Ischemia-reperfusion Injury Remodels Skeletal Muscle Motor Unit, Myonuclear-, And Mitochondrial-domains
    Volume: 51 Page(s): 497 - 498
    06/01/2019 Authors: Lee NH; Mohiuddin M; Moon A; Han W; Anderson S; Choi J; Shin E; Nakhai S; Thu T; Aliya B
  • Stressed Neutrophils Impede Vascular Repair
    Volume: 138
    11/06/2018 Authors: Okwan-Duodu D; Liu W; Xu K; Quintana R; Hansen L; Sellak H; Joseph G; Levit R; Archer D; Taylor WR
  • The small heat shock protein HSPB1 protects mice from sepsis.
    Sci Rep Volume: 8 Page(s): 12493
    08/21/2018 Authors: Breed ER; Hilliard CA; Yoseph B; Mittal R; Liang Z; Chen C-W; Burd EM; Brewster LP; Hansen LM; Gleason RL
  • Impaired Collateral Vessel Formation in Sickle Cell Disease.
    Arterioscler Thromb Vasc Biol Volume: 38 Page(s): 1125 - 1133
    05/01/2018 Authors: Okwan-Duodu D; Hansen L; Joseph G; Lyle AN; Weiss D; Archer DR; Taylor WR
  • Does the Sickle Trait Portend Increased Cardiovascular Risks?
    Volume: 38
    05/01/2018 Authors: Okwan-Duodu D; Quintana RA; Joseph G; Hansen L; Liu W; Sellak H; Archer D; Taylor WR
  • Neutrophils Aged Under Oxidative Stress Impede Vascular Repair
    Volume: 38
    05/01/2018 Authors: Okwan-Duodu D; Liu W; Xu K; Shin E; Quintana RA; Joseph G; Hansen L; Sellak H; Levit R; Archer D
  • Skeletal Muscle Satellite Cells Play a Role in Regulating Angiogenesis and Arteriogenesis
    Volume: 38
    05/01/2018 Authors: Hansen LM; Liu W; Joseph G; Taylor WR
  • Satellite Cells Influence Collateral Vessel Formation via Paracrine Effects
    Volume: 37
    05/01/2017 Authors: Hansen L; Liu W; Joseph G; Weiss D; Taylor WR
  • Neutrophil-Mediated Inflammation Drives Sickle Cell Vasculopathy
    Volume: 37
    05/01/2017 Authors: Okwan D; Hansen L; Joseph G; Weiss D; Archer DR; Taylor WR
  • The Paracrine Effects of Satellite Cells on Collateral Vessel Formation
    Volume: 31
    04/01/2017 Authors: Hansen L; Liu W; Joseph G; Weiss D; Taylor WR
  • The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice.
    Lab Invest Volume: 97 Page(s): 34 - 42
    01/01/2017 Authors: Hansen LM; Gupta D; Joseph G; Weiss D; Taylor WR
  • Is increased arterial stiffness a cause or consequence of atherosclerosis?
    Atherosclerosis Volume: 249 Page(s): 226 - 227
    06/01/2016 Authors: Hansen L; Taylor WR
  • Satellite Cells are a Major Source of the Receptor for Advanced Glycation End Products in the Ischemic Leg and Play a Role in Collateral Growth
    CIRCULATION Volume: 130
    11/25/2014 Authors: Hansen LM; Lyle AN; Joseph G; Weiss D; Taylor WR
  • Pro-atherogenic shear stress and HIV proteins synergistically upregulate cathepsin K in endothelial cells.
    Ann Biomed Eng Volume: 42 Page(s): 1185 - 1194
    06/01/2014 Authors: Parker IK; Roberts LM; Hansen L; Gleason RL; Sutliff RL; Platt MO
  • Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling.
    PLoS One Volume: 9 Page(s): e105101
    01/01/2014 Authors: Sutliff RL; Walp ER; Kim YH; Walker LA; El-Ali AM; Ma J; Bonsall R; Ramosevac S; Eaton DC; Verlander JW
  • Polymerase delta interacting protein 2 sustains vascular structure and function.
    Arterioscler Thromb Vasc Biol Volume: 33 Page(s): 2154 - 2161
    09/01/2013 Authors: Sutliff RL; Hilenski LL; Amanso AM; Parastatidis I; Dikalova AE; Hansen L; Datla SR; Long JS; El-Ali AM; Joseph G
  • Azidothymidine (AZT) leads to arterial stiffening and intima-media thickening in mice.
    J Biomech Volume: 46 Page(s): 1540 - 1547
    05/31/2013 Authors: Hansen L; Parker I; Roberts LM; Sutliff RL; Platt MO; Gleason RL
  • Endothelial dysfunction, arterial stiffening, and intima-media thickening in large arteries from HIV-1 transgenic mice.
    Ann Biomed Eng Volume: 41 Page(s): 682 - 693
    04/01/2013 Authors: Hansen L; Parker I; Sutliff RL; Platt MO; Gleason RL
  • A 3-D constrained mixture model for mechanically mediated vascular growth and remodeling.
    Biomech Model Mechanobiol Volume: 9 Page(s): 403 - 419
    08/01/2010 Authors: Wan W; Hansen L; Gleason RL
  • Microstructurally motivated constitutive modeling of mouse arteries cultured under altered axial stretch.
    J Biomech Eng Volume: 131 Page(s): 101015
    10/01/2009 Authors: Hansen L; Wan W; Gleason RL
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