Lih-Shen Chin PhD
- Department of Pharmacology & Chemical Biology
Associate Professor
- (404) 727-0361
- lchin@emory.edu
-
Emory University School of Medicine
Pharmacology
1510 Clifton Rd., RRC Room 5107
Overview
Our research interest is to elucidate the molecular pathogenic mechanisms of Parkinsons disease. Although Parkinson's disease (PD) has been known for nearly two centuries, the molecular mechanisms underlying the pathogenesis of PD remain poorly understood, and currently there is no cure to stop the progression of this devastating disease. Our research is focused on the pathogenic mechanisms of Parkinson's disease. We are using a multifaceted approach to delineate the molecular pathways by which mutations in familial PD proteins DJ-1, Parkin, and PINK1 lead to neurodegeneration and to identify additional players in the PD pathogenic pathways. We are also studying oxidative damage in idiopathic PD brains and investigating the gene-environment interactions in PD pathogenesis. Our goal is to use the mechanistic insights gained from these studies for developing new intervention strategies to treat PD.
Academic Appointment
- Associate Professor, Department of Pharmacology and Chemical Biology, Emory University School of Medicine
Education
Degrees
- PhD from University of California
- BS from National Taiwan University
Research
Focus
- (1) Pathogenic mechanisms of Parkinsons disease and other neurological disorders (2) Regulation of neuronal survival and function by the ubiquitin-proteasome system (3) Cytoprotective mechanisms against misfolded and aggregated proteins
Publications
-
An Integrated Proteomic and Glycoproteomic Investigation Reveals Alterations in the N-Glycoproteomic Network Induced by 2-Deoxy-D-Glucose in Colorectal Cancer Cells.
Int J Mol Sci Volume: 23
07/26/2022 Authors: Ma C; Tsai H-Y; Zhang Q; Senavirathna L; Li L; Chin L-S; Chen R; Pan S -
DJ-1 attenuates the glycation of mitochondrial complex I and complex III in the post-ischemic heart.
Sci Rep Volume: 11 Page(s): 19408
09/30/2021 Authors: Pantner Y; Polavarapu R; Chin L-S; Li L; Shimizu Y; Calvert JW -
Differential Analysis of N-glycopeptide Abundance and N-glycosylation Site Occupancy for Studying Protein N-glycosylation Dysregulation in Human Disease.
Bio Protoc Volume: 11 Page(s): e4059
06/20/2021 Authors: Zhang Q; Ma C; Li L; Chin L-S -
Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer's disease.
Sci Adv Volume: 6
10/01/2020 Authors: Zhang Q; Ma C; Chin L-S; Li L -
Role of DJ-1 in Modulating Glycative Stress in Heart Failure.
J Am Heart Assoc Volume: 9 Page(s): e014691
02/18/2020 Authors: Shimizu Y; Nicholson CK; Polavarapu R; Pantner Y; Husain A; Naqvi N; Chin L-S; Li L; Calvert JW -
TDP-43 cytoplasmic inclusion formation is disrupted in C9orf72-associated amyotrophic lateral sclerosis/frontotemporal lobar degeneration.
Brain Commun Volume: 1 Page(s): fcz014
01/01/2019 Authors: Lee SM; Asress S; Hales CM; Gearing M; Vizcarra JC; Fournier CN; Gutman DA; Chin L-S; Li L; Glass JD -
Hypertonia-linked protein Trak1 functions with mitofusins to promote mitochondrial tethering and fusion.
Protein Cell Volume: 9 Page(s): 693 - 716
08/01/2018 Authors: Lee CA; Chin L-S; Li L -
Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease.
Acta Neuropathol Commun Volume: 6 Page(s): 19
03/01/2018 Authors: Zhang Q; Ma C; Gearing M; Wang PG; Chin L-S; Li L -
Dysregulation of ErbB Receptor Trafficking and Signaling in Demyelinating Charcot-Marie-Tooth Disease.
Mol Neurobiol Volume: 54 Page(s): 87 - 100
01/01/2017 Authors: Lee SM; Chin L-S; Li L -
Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance.
Mol Neurobiol Volume: 53 Page(s): 6270 - 6287
11/01/2016 Authors: Yung C; Sha D; Li L; Chin L-S