Luke Brewster
Overview
Dr. Brewster's clinical practice is focused on general vascular surgery and peripheral arterial disease, and his affiliations include Emory University Hospital and serving as section chief of vascular surgery at the Atlanta VA Healthcare System.
As a surgeon-scientist, his joint affiliations with the Atlanta Clinical and Translational Science Institute and the Wallace Coulter Department of Biomedical Engineering at Georgia Tech/Emory have given him access to an exceptional pool of collaborators, and he has received a steady stream of various federal, foundation, and industry grants.
Dr. Brewster's laboratory focuses on investigations of the biomechanical mechanisms that contribute to pathologic vessel remodeling in peripheral vascular disease, develops regenerative strategies for use in ischemic tissue, and works to improve the function of patients who succumb to major amputation.
Academic Appointment
- Associate Professor Surgery, Division of Vascular Surgery, Department of Surgery, Emory University School of Medicine
- Program Faculty, Bioengineering Program, Georgia Institute of Technology
- Scientific Advisory Committee Member, Atlanta Clinical & Translational Science Institute
- Staff Scientist, Emory National Primate Research Center
Education
Degrees
- MD from Saint Louis University School of Medicine
- PhD from Loyola University Medical Center
- MA from Neiswanger Institute, LUMC
- BA from Benedictine College
Research
Focus
- Arteriosclerosis or stiffening of the arterial blood vessels changes the pulsativity of blood flow, and as such, dysregulates flow from the heart to the desired tissue bed. My laboratory investigates the mechanisms of this disease and develops therapeutics to restore full hysteresis to diseased arteries in invivo and exvivo systems.
Publications
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Endothelial cell (EC)-specific Ctgf/Ccn2 expression increases EC reprogramming and atherosclerosis.
Matrix Biol Volume: 136 Page(s): 102 - 110
04/01/2025 Authors: Li F; Kumar S; Pokutta-Paskaleva A; Kang D-W; Kim C; Raykin J; Omojola V; Hoffmann C; Zhao F; Teichmann M -
Structured Exercise Therapy Increases Endogenous Antioxidants to Repair Muscle Strength and Health in Porcine Ischemic Myopathy Model of Peripheral Artery Disease.
Adv Wound Care (New Rochelle)
02/05/2025 Authors: Hoffmann C; Foster D; Fletcher E; Sasaki M; Li F; McLaughlin D; Cui X; Koutakis P; Call JA; Brewster L -
Smoking Status Impacts Mitochondrial Function and Synthetic Function in Mesenchymal Stem Cells Derived from Diabetics with Arterial Insufficiency.
Adv Wound Care (New Rochelle)
12/20/2024 Authors: McLaughlin D; Sasaki M; Hoffmann C; Brewster L; E Hekman K -
Prosthetic fitting and mortality after major lower extremity amputation.
J Vasc Surg Volume: 80 Page(s): 529 - 536
08/01/2024 Authors: Forrester N; Donzo MW; Hu C; Mize BM; Hui KH; Duwayri Y; Brewster L; Alabi O -
Factors associated with 90-day reintervention following lower extremity revascularization.
J Vasc Surg Volume: 80 Page(s): 213 - 222.e1
07/01/2024 Authors: Alabi O; Harding JL; Massarweh N; Zheng X; Brewster L; Mao J; Duwayri Y -
2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Circulation Volume: 149 Page(s): e1313 - e1410
06/11/2024 Authors: Gornik HL; Aronow HD; Goodney PP; Arya S; Brewster LP; Byrd L; Chandra V; Drachman DE; Eaves JM; Ehrman JK -
Search Engines to Capture Missing Deaths From Institutional Data Warehouse.
J Surg Res Volume: 294 Page(s): 220 - 227
02/01/2024 Authors: Dayal YS; Foster DG; Hao Y; Bennett SG; Brewster LP -
Dyslipidemia impairs collateral artery formation after hindlimb ischemia: Adding insult to injury.
JVS Vasc Sci Volume: 5 Page(s): 100204
01/01/2024 Authors: Hakim AH; Brewster L -
Hyperoxia impairs induced pluripotent stem cell-derived endothelial cells and drives an atherosclerosis-like transcriptional phenotype.
JVS Vasc Sci Volume: 5 Page(s): 100193
01/01/2024 Authors: Carr SM; Owsiany K; Scrivner O; McLaughlin D; Jo H; Brewster LP; Hekman KE -
Association between readmission care fragmentation and outcomes after interventions for peripheral arterial disease.
J Vasc Surg Volume: 78 Page(s): 1513 - 1522.e1
12/01/2023 Authors: Alabi O; Massarweh NN; Zheng X; Brewster L; Mao J; Duwayri Y