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Profile

Kosuke Kato

  • Department of Medicine
    Assistant Professor
  • kosuke.kato@emory.edu
Head shot of Kosuke Kato

Academic Appointment

  • Assistant Professor, Emory University

Education

Degrees

  • PhD from Kumamoto University

Research

Publications

  • Preclinical Evaluation of Dimethyl Fumarate in an Aging Model of Pulmonary Fibrosis In vivo
    Volume: 205
    05/01/2022 Authors: Kato K; Hecker L
  • Nox4 Mediates Age-Associated Endothelial Barrier Dysfunction and Severity of Pre-Clinical ARDS
    Volume: 205
    05/01/2022 Authors: Kato K; Hecker L
  • Lung-Targeted Delivery of Dimethyl Fumarate Promotes the Reversal of Age-Dependent Established Lung Fibrosis.
    Antioxidants (Basel) Volume: 11
    02/28/2022 Authors: Kato K; Papageorgiou I; Shin Y-J; Kleinhenz JM; Palumbo S; Hahn S; Irish JD; Rounseville SP; Knox KS; Hecker L
  • Leveraging ageing models of pulmonary fibrosis: the efficacy of nintedanib in ageing.
    Eur Respir J Volume: 58
    11/01/2021 Authors: Kato K; Shin Y-J; Palumbo S; Papageorgiou I; Hahn S; Irish JD; Rounseville SP; Krafty RT; Wollin L; Sauler M
  • Nintedanib Inhibits Pulmonary Fibrosis Development in Aged Mice but Does Not Reverse Age-Dependent Established Fibrosis
    Volume: 203
    05/01/2021 Authors: Kato K; Shin Y; Irish J; Rounseville S; Sauler M; Wollin SL; Hecker L
  • IV Delivery of Novel Nox4 Inhibitors as a Therapeutic Approach to Target Age-Dependent Severe ARDS
    Volume: 203
    05/01/2021 Authors: Hecker L; Kato K; Gokhale V
  • Identification of Highly Selective First-in-Class Small-Molecule Inhibitors of Nox4 for Pulmonary Fibrosis
    Volume: 203
    05/01/2021 Authors: Hecker L; Knox A; Kato K; Gokhale V
  • Novel Screening Methods to Identify Nox4 Inhibitors
    Volume: 203
    05/01/2021 Authors: Hecker L; Irish J; Rounseville S; Knox A; Kato K; Gokhale V
  • MUC1 contributes to goblet cell metaplasia and MUC5AC expression in response to cigarette smoke in vivo.
    Am J Physiol Lung Cell Mol Physiol Volume: 319 Page(s): L82 - L90
    07/01/2020 Authors: Kato K; Chang EH; Chen Y; Lu W; Kim MM; Niihori M; Hecker L; Kim KC
  • NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis.
    Redox Biol Volume: 33 Page(s): 101541
    06/01/2020 Authors: Kato K; Hecker L
  • Impaired Myofibroblast Dedifferentiation Contributes to Nonresolving Fibrosis in Aging.
    Am J Respir Cell Mol Biol Volume: 62 Page(s): 633 - 644
    05/01/2020 Authors: Kato K; Logsdon NJ; Shin Y-J; Palumbo S; Knox A; Irish JD; Rounseville SP; Rummel SR; Mohamed M; Ahmad K
  • Impaired Myofibroblast Dedifferentiation Contributes to Non-Resolving Fibrosis in Aging
    Volume: 201
    01/01/2020 Authors: Hecker L; Kato K; Shin Y; Thannickal VJ
  • Nox4 Mediates Age-Associated Endothelial Barrier Dysfunction and Acute Lung Injury Severity
    Volume: 201
    01/01/2020 Authors: Hecker L; Palumbo S; Shin Y; Kato K
  • Identification of First-In-Class Small-Molecule Inhibitors for Selective Targeting of Nox4 for Pulmonary Fibrosis
    Volume: 201
    01/01/2020 Authors: Knox A; Kato K; Gokhale V; Knox KS; Hecker L
  • Nampt Promotes Pro-Fibrotic Myofibroblasts Phenotypes in Age-Dependent Pulmonary Fibrosis
    Volume: 201
    01/01/2020 Authors: Kato K; Palumbo S; Shin Y; Hahn S; Hecker L
  • A Comprehensive Systematic Review of the Association Between Airway Mucins and Chronic Rhinosinusitis.
    Am J Rhinol Allergy Volume: 33 Page(s): 433 - 448
    07/01/2019 Authors: Kato K; Song BH; Howe CL; Chang EH
  • Membrane-associated Mucin 1 (MUC1) Promotes Epidermal Growth Factor Receptor (EGFR)-mediated Mucin 5AC (MUC5AC) Overproduction in Chronic Airway Disease
    Volume: 143 Page(s): AB211 - AB211
    02/01/2019 Authors: Kato K; Chang EH; Chen Y; Kim KC
  • MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function.
    J Clin Med Volume: 6
    11/29/2017 Authors: Kato K; Lillehoj EP; Lu W; Kim KC
  • Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis.
    Biochem Biophys Res Commun Volume: 493 Page(s): 1230 - 1235
    11/25/2017 Authors: Kato K; Zemskova MA; Hanss AD; Kim MM; Summer R; Kim KC
  • Pseudomonas aeruginosa increases MUC1 expression in macrophages through the TLR4-p38 pathway.
    Biochem Biophys Res Commun Volume: 492 Page(s): 231 - 235
    10/14/2017 Authors: Kato K; Hanss AD; Zemskova MA; Morgan NE; Kim M; Knox KS; Lin Y; Lillehoj EP; Kim KC
  • Muc1 knockout potentiates murine lung carcinogenesis involving an epiregulin-mediated EGFR activation feedback loop.
    Carcinogenesis Volume: 38 Page(s): 604 - 614
    06/01/2017 Authors: Xu X; Chen W; Leng S; Padilla MT; Saxton B; Hutt J; Tessema M; Kato K; Kim KC; Belinsky SA
  • Membrane-Tethered MUC1 Mucin Counter-Regulates the Phagocytic Activity of Macrophages.
    Am J Respir Cell Mol Biol Volume: 54 Page(s): 515 - 523
    04/01/2016 Authors: Kato K; Uchino R; Lillehoj EP; Knox K; Lin Y; Kim KC
  • Pseudomonas aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation.
    Inflamm Res Volume: 65 Page(s): 225 - 233
    03/01/2016 Authors: Kato K; Lillehoj EP; Kim KC
  • The Signaling Pathway Involved In Muc1 Mucin Upregulation In Macrophages During Pseudomonas AerugINOSa Infection
    Volume: 193
    01/01/2016 Authors: Kato K; Hanss A; Morgan N; Knox KS; Lillehoj EP; Kim K
  • A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance.
    Carcinogenesis Volume: 35 Page(s): 2457 - 2466
    11/01/2014 Authors: Xu X; Wells A; Padilla MT; Kato K; Kim KC; Lin Y
  • MUC1 regulates epithelial inflammation and apoptosis by PolyI:C through inhibition of Toll/IL-1 receptor-domain-containing adapter-inducing IFN- (TRIF) recruitment to Toll-like receptor 3.
    Am J Respir Cell Mol Biol Volume: 51 Page(s): 446 - 454
    09/01/2014 Authors: Kato K; Lillehoj EP; Kim KC
  • Lipopolysaccharide decreases single immunoglobulin interleukin-1 receptor-related molecule (SIGIRR) expression by suppressing specificity protein 1 (Sp1) via the Toll-like receptor 4 (TLR4)-p38 pathway in monocytes and neutrophils.
    J Biol Chem Volume: 289 Page(s): 18097 - 18109
    06/27/2014 Authors: Ueno-Shuto K; Kato K; Tasaki Y; Sato M; Sato K; Uchida Y; Sakai H; Ono T; Suico MA; Mitsutake K
  • MUC1 in macrophage: contributions to cigarette smoke-induced lung cancer.
    Cancer Res Volume: 74 Page(s): 460 - 470
    01/15/2014 Authors: Xu X; Padilla MT; Li B; Wells A; Kato K; Tellez C; Belinsky SA; Kim KC; Lin Y
  • Prevention of lung injury by Muc1 mucin in a mouse model of repetitive Pseudomonas aeruginosa infection.
    Inflamm Res Volume: 61 Page(s): 1013 - 1020
    09/01/2012 Authors: Umehara T; Kato K; Park YS; Lillehoj EP; Kawauchi H; Kim KC
  • PPAR inhibits airway epithelial cell inflammatory response through a MUC1-dependent mechanism.
    Am J Physiol Lung Cell Mol Physiol Volume: 302 Page(s): L679 - L687
    04/01/2012 Authors: Park YS; Lillehoj EP; Kato K; Park CS; Kim KC
  • Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88.
    J Immunol Volume: 188 Page(s): 2014 - 2022
    02/15/2012 Authors: Kato K; Lillehoj EP; Park YS; Umehara T; Hoffman NE; Madesh M; Kim KC
  • Antiinflammatory role of MUC1 mucin during infection with nontypeable Haemophilus influenzae.
    Am J Respir Cell Mol Biol Volume: 46 Page(s): 149 - 156
    02/01/2012 Authors: Kyo Y; Kato K; Park YS; Gajghate S; Umehara T; Lillehoj EP; Suzaki H; Kim KC
  • MUC1 expression by human airway epithelial cells mediates Pseudomonas aeruginosa adhesion.
    Front Biosci (Elite Ed) Volume: 2 Page(s): 68 - 77
    01/01/2010 Authors: Kato K; Lillehoj EP; Kai H; Kim KC
  • MUC1 mucin is a negative regulator of toll-like receptor signaling.
    Am J Respir Cell Mol Biol Volume: 38 Page(s): 263 - 268
    03/01/2008 Authors: Ueno K; Koga T; Kato K; Golenbock DT; Gendler SJ; Kai H; Kim KC
  • Phosphoinositide 3-kinase is activated by MUC1 but not responsible for MUC1-induced suppression of Toll-like receptor 5 signaling.
    Am J Physiol Lung Cell Mol Physiol Volume: 293 Page(s): L686 - L692
    09/01/2007 Authors: Kato K; Lu W; Kai H; Kim KC
  • Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice.
    J Immunol Volume: 176 Page(s): 3890 - 3894
    04/01/2006 Authors: Lu W; Hisatsune A; Koga T; Kato K; Kuwahara I; Lillehoj EP; Chen W; Cross AS; Gendler SJ; Gewirtz AT
  • Membrane-anchored CD14 is required for LPS-induced TLR4 endocytosis in TLR4/MD-2/CD14 overexpressing CHO cells.
    Biochem Biophys Res Commun Volume: 338 Page(s): 1402 - 1409
    12/23/2005 Authors: Shuto T; Kato K; Mori Y; Viriyakosol S; Oba M; Furuta T; Okiyoneda T; Arima H; Suico MA; Kai H
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