Katrin Henke
- Department of Orthopaedics
Assistant Professor
Overview
Our lab explores gene function during development, homeostasis and disease of the musculoskeletal system utilizing the zebrafish as a model. Zebrafish are widely used in biomedical research due to ease of genetic manipulation, high fecundity, external fertilization, rapid early development and transparency of early life stages. They show strong similarities with human physiology and in genetic architecture. While at first glance the skeleton of the zebrafish looks very different compared to a human skeleton, it contains the same major cell types and shows strong correlation in its structure and genetic regulation. Taking advantage of the many imaging, genetic and genomic tools in zebrafish and the diverse expertise in the Orthopaedics Department, we seek to gain crucial insight into musculoskeletal biology, disease etiology and progression to aid in the development of new treatments and therapeutic strategies.
Academic Appointment
- Assistant Professor, Department of Human Genetics, Emory University School of Medicine
- Assistant Professor, Department of Orthopaedics, Emory University School of Medicine
Education
Degrees
- PhD from Max Planck Institute for Developmental Biology
- M.Sc. in Molecular Medicine from University of Erlangen-Nuremberg
Research
Publications
-
Inhibition of KDM2/7 Promotes Notochordal Differentiation of hiPSCs.
Cells Volume: 13
09/04/2024 Authors: Diaz-Hernandez ME; Murakami K; Murata S; Khan NM; Shenoy SPV; Henke K; Yamada H; Drissi H -
Current perspectives on the multiple roles of osteoclasts: Mechanisms of osteoclast-osteoblast communication and potential clinical implications.
Elife Volume: 13
04/09/2024 Authors: Daponte V; Henke K; Drissi H -
The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafish.
PLoS Genet Volume: 19 Page(s): e1010589
08/01/2023 Authors: Islam KN; Ajao A; Venkataramani K; Rivera J; Pathania S; Henke K; Siegfried KR -
Loss of lrp5 in zebrafish reveals unexpected role of Lrp5 in osteoclast regulation
Volume: 38 Page(s): 279 - 280
02/01/2023 Authors: Khrystoforova I; Shochat-Carvalho C; Harari R; David K; Henke K; Woronowicz K; Harris M -
Genetically engineered zebrafish as models of skeletal development and regeneration.
Bone Volume: 167 Page(s): 116611
02/01/2023 Authors: Henke K; Farmer DT; Niu X; Kraus JM; Galloway JL; Youngstrom DW -
Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis model.
iScience Volume: 25 Page(s): 105028
09/16/2022 Authors: Meyer-Miner A; Van Gennip JLM; Henke K; Harris MP; Ciruna B -
Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation.
Front Endocrinol (Lausanne) Volume: 13 Page(s): 985304
01/01/2022 Authors: Khrystoforova I; Shochat-Carvalho C; Harari R; Henke K; Woronowicz K; Harris MP; Karasik D -
Latent developmental potential to form limb-like skeletal structures in zebrafish.
Cell Volume: 184 Page(s): 899 - 911.e13
02/18/2021 Authors: Hawkins MB; Henke K; Harris MP -
Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine.
Curr Biol Volume: 30 Page(s): 2805 - 2814.e3
07/20/2020 Authors: Peskin B; Henke K; Cumplido N; Treaster S; Harris MP; Bagnat M; Arratia G -
SCO-Spondin Defects and Neuroinflammation Are Conserved Mechanisms Driving Spinal Deformity across Genetic Models of Idiopathic Scoliosis.
Curr Biol Volume: 30 Page(s): 2363 - 2373.e6
06/22/2020 Authors: Rose CD; Pompili D; Henke K; Van Gennip JLM; Meyer-Miner A; Rana R; Gobron S; Harris MP; Nitz M; Ciruna B