Karen Conneely PhD
- Department of Human Genetics
Associate Professor
- (404) 727-2986
- kconnee@emory.edu
-
615 Michael Street
Suite 344
Atlanta, GA 30322
Overview
My research focuses on the application and development of statistical methods for detecting genetic and epigenetic variation associated with complex traits. Through the development of novel techniques and adaptation of existing ones, my work seeks to identify biomarkers and variants involved in disease, and to explore the role of DNA methylation as mediator between genetic variation, environment and phenotype. Ongoing work in the Conneely lab uses computational approaches to understand the relationship between multiple epigenetic mechanisms, gene expression, and human aging, with particular interest in the epigenomic and transcriptomic consequences of clonal hematopoiesis of indeterminate potential.
Academic Appointment
- Associate Professor, Department of Human Genetics, Emory University School of Medicine
- Associate Professor, Department of Biostatistics & Bioinformatics, Emory University
Education
Degrees
- PhD from University of Michigan
- M.S. from University of Michigan
- MA from Princeton University
- BS from University of Illinois
Research
Focus
-
Statistical methods for detecting genetic and epigenetic variation associated with complex traits.
My research focuses on statistical methods for detecting genetic and epigenetic variation associated with complex traits. Through the development of novel techniques and the application of existing ones, my work seeks to 1) identify biomarkers and variants predisposing to disease, and 2) explore the role of DNA methylation as a mediator between genetic variation, environment and phenotype, with a focus on epigenetic changes that occur during aging.
Publications
-
SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.
03/26/2025 Authors: Cooper GW; Lee BP; Kim WJ; Su Y; Chen VZ; Salas E; Yang X; Lintner RE; Piccioni F; Giacomelli AO -
Adverse Childhood Experiences and Accelerated Epigenetic Aging in the Hispanic Community Health Study/Study of Latinos: Nativity as an Effect Modifier.
Psychoneuroendocrinology Volume: 173 Page(s): 107369
03/01/2025 Authors: Chen Y; Abrishamcar S; Johnson S; Aqua J; Dye C; Llabre MM; Gallo LC; Pereira KM; Daviglus M; Argos M -
Whole-genome bisulfite sequencing of cell-free DNA unveils age-dependent and ALS-associated methylation alterations.
Cell Biosci Volume: 15 Page(s): 26
02/20/2025 Authors: Jin Y; Conneely KN; Ma W; Naviaux RK; Siddique T; Allen EG; Guingrich S; Pascuzzi RM; Jin P -
DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism.
Mol Psychiatry Volume: 30 Page(s): 76 - 83
01/01/2025 Authors: Xiao C; Peng G; Conneely KN; Zhao H; Felger JC; Wommack EC; Higgins KA; Shin DM; Saba NF; Bruner DW -
Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment.
Sci Rep Volume: 14 Page(s): 18147
08/05/2024 Authors: Hodge KM; Burt AA; Camerota M; Carter BS; Check J; Conneely KN; Helderman J; Hofheimer JA; Hls A; McGowan EC -
Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation.
Res Sq
07/16/2024 Authors: Levy D; Kirmani S; Huan T; Van Amburg J; Joehanes R; Uddin MM; Nguyen NQ; Yu B; Brody J; Fornage M -
Associations of childhood, adolescence, and midlife cognitive function with DNA methylation age acceleration in midlife.
Aging (Albany NY) Volume: 16 Page(s): 9350 - 9368
06/13/2024 Authors: Chen J; Moubadder L; Clausing ES; Kezios KL; Conneely KN; Hls A; Baccarelli A; Factor-Litvak P; Cirrillo P; Shelton RC -
Investigating the potential of single-cell DNA methylation data to detect allele-specific methylation and imprinting.
Am J Hum Genet Volume: 111 Page(s): 654 - 667
04/04/2024 Authors: Johnson ND; Cutler DJ; Conneely KN -
Cumulative Stress Across the Life Course and Biological Aging in Adulthood.
Psychosom Med Volume: 86 Page(s): 137 - 145
04/01/2024 Authors: Suglia SF; Clausing ES; Shelton RC; Conneely K; Prada-Ortega D; DeVivo I; Factor-Litvak P; Cirillo P; Baccarelli AA; Cohn B -
Pruning and thresholding approach for methylation risk scores in multi-ancestry populations.
Epigenetics Volume: 18 Page(s): 2187172
12/01/2023 Authors: Chen J; Gatev E; Everson T; Conneely KN; Koen N; Epstein MP; Kobor MS; Zar HJ; Stein DJ; Hls A