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Profile

Karen Conneely PhD

  • Department of Human Genetics
    Associate Professor
  • (404) 727-2986
  • kconnee@emory.edu
  • 615 Michael Street
    Suite 344
    Atlanta, GA 30322
Head shot of Karen Conneely

Overview

My research focuses on the application and development of statistical methods for detecting genetic and epigenetic variation associated with complex traits. Through the development of novel techniques and adaptation of existing ones, my work seeks to identify biomarkers and variants involved in disease, and to explore the role of DNA methylation as mediator between genetic variation, environment and phenotype. Ongoing work in the Conneely lab uses computational approaches to understand the relationship between multiple epigenetic mechanisms, gene expression, and human aging, with particular interest in the epigenomic and transcriptomic consequences of clonal hematopoiesis of indeterminate potential.

Academic Appointment

  • Associate Professor, Department of Human Genetics, Emory University School of Medicine
  • Associate Professor, Department of Biostatistics & Bioinformatics, Emory University

Education

Degrees

  • PhD from University of Michigan
  • M.S. from University of Michigan
  • MA from Princeton University
  • BS from University of Illinois

Research

Focus

  • Statistical methods for detecting genetic and epigenetic variation associated with complex traits.

    My research focuses on statistical methods for detecting genetic and epigenetic variation associated with complex traits. Through the development of novel techniques and the application of existing ones, my work seeks to 1) identify biomarkers and variants predisposing to disease, and 2) explore the role of DNA methylation as a mediator between genetic variation, environment and phenotype, with a focus on epigenetic changes that occur during aging.

Publications

  • SMARCB1 missense mutants disrupt SWI/SNF complex stability and remodeling activity.

    03/26/2025 Authors: Cooper GW; Lee BP; Kim WJ; Su Y; Chen VZ; Salas E; Yang X; Lintner RE; Piccioni F; Giacomelli AO
  • Adverse Childhood Experiences and Accelerated Epigenetic Aging in the Hispanic Community Health Study/Study of Latinos: Nativity as an Effect Modifier.
    Psychoneuroendocrinology Volume: 173 Page(s): 107369
    03/01/2025 Authors: Chen Y; Abrishamcar S; Johnson S; Aqua J; Dye C; Llabre MM; Gallo LC; Pereira KM; Daviglus M; Argos M
  • Whole-genome bisulfite sequencing of cell-free DNA unveils age-dependent and ALS-associated methylation alterations.
    Cell Biosci Volume: 15 Page(s): 26
    02/20/2025 Authors: Jin Y; Conneely KN; Ma W; Naviaux RK; Siddique T; Allen EG; Guingrich S; Pascuzzi RM; Jin P
  • DNA methylation profiles of cancer-related fatigue associated with markers of inflammation and immunometabolism.
    Mol Psychiatry Volume: 30 Page(s): 76 - 83
    01/01/2025 Authors: Xiao C; Peng G; Conneely KN; Zhao H; Felger JC; Wommack EC; Higgins KA; Shin DM; Saba NF; Bruner DW
  • Epigenetic associations with neonatal age in infants born very preterm, particularly among genes involved in neurodevelopment.
    Sci Rep Volume: 14 Page(s): 18147
    08/05/2024 Authors: Hodge KM; Burt AA; Camerota M; Carter BS; Check J; Conneely KN; Helderman J; Hofheimer JA; Hls A; McGowan EC
  • Epigenome-wide DNA Methylation Association Study of CHIP Provides Insight into Perturbed Gene Regulation.
    Res Sq
    07/16/2024 Authors: Levy D; Kirmani S; Huan T; Van Amburg J; Joehanes R; Uddin MM; Nguyen NQ; Yu B; Brody J; Fornage M
  • Associations of childhood, adolescence, and midlife cognitive function with DNA methylation age acceleration in midlife.
    Aging (Albany NY) Volume: 16 Page(s): 9350 - 9368
    06/13/2024 Authors: Chen J; Moubadder L; Clausing ES; Kezios KL; Conneely KN; Hls A; Baccarelli A; Factor-Litvak P; Cirrillo P; Shelton RC
  • Investigating the potential of single-cell DNA methylation data to detect allele-specific methylation and imprinting.
    Am J Hum Genet Volume: 111 Page(s): 654 - 667
    04/04/2024 Authors: Johnson ND; Cutler DJ; Conneely KN
  • Cumulative Stress Across the Life Course and Biological Aging in Adulthood.
    Psychosom Med Volume: 86 Page(s): 137 - 145
    04/01/2024 Authors: Suglia SF; Clausing ES; Shelton RC; Conneely K; Prada-Ortega D; DeVivo I; Factor-Litvak P; Cirillo P; Baccarelli AA; Cohn B
  • Pruning and thresholding approach for methylation risk scores in multi-ancestry populations.
    Epigenetics Volume: 18 Page(s): 2187172
    12/01/2023 Authors: Chen J; Gatev E; Everson T; Conneely KN; Koen N; Epstein MP; Kobor MS; Zar HJ; Stein DJ; Hls A
  • Multi-omic analysis of multiple myeloma subtypes reveals epigenetic programs of high-risk disease
    Volume: 23 Page(s): S222 - S223
    09/01/2023 Authors: Barwick B; Powell D; Chavez R; Cook A; Hamilton M; Mulligan G; Auclair D; Conneely K; Vertino P; Boise L
  • Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-treatment DNA Methylation From Peripheral Blood.
    Int J Radiat Oncol Biol Phys Volume: 115 Page(s): 1217 - 1228
    04/01/2023 Authors: Qian DC; Ulrich BC; Peng G; Zhao H; Conneely KN; Miller AH; Bruner DW; Eldridge RC; Wommack EC; Higgins KA
  • Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC.
    Clin Epigenetics Volume: 15 Page(s): 50
    03/24/2023 Authors: Venkateswaran S; Somineni HK; Matthews JD; Kilaru V; Hyams JS; Denson LA; Kellamayer R; Gibson G; Cutler DJ; Conneely KN
  • Elimination of PBB-153; findings from a cohort of Michigan adults.
    Environ Res Volume: 220 Page(s): 115146
    03/01/2023 Authors: Hood RB; Terrell ML; Smith AK; Curtis S; Conneely K; Pearson M; Barton H; Barr DB; Marder EM; Marcus M
  • Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI.
    Am J Hum Genet Volume: 110 Page(s): 273 - 283
    02/02/2023 Authors: Do WL; Sun D; Meeks K; Dugu P-A; Demerath E; Guan W; Li S; Chen W; Milne R; Adeyemo A
  • Redlining-associated methylation in breast tumors: the impact of contemporary structural racism on the tumor epigenome.
    Front Oncol Volume: 13 Page(s): 1154554
    01/01/2023 Authors: Miller-Kleinhenz JM; Moubadder L; Beyer KM; Zhou Y; Gaglioti AH; Collin LJ; Gohar J; Do W; Conneely K; Krishnamurti U
  • Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease.
    Nat Commun Volume: 13 Page(s): 5350
    09/12/2022 Authors: Uddin MDM; Nguyen NQH; Yu B; Brody JA; Pampana A; Nakao T; Fornage M; Bressler J; Sotoodehnia N; Weinstock JS
  • Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of U.S. adults.
    Volume: 212 Page(s): 113360
    09/01/2022 Authors: Holliday KM; Gondalia R; Baldassari A; Justice AE; Stewart JD; Liao D; Yanosky JD; Jordahl KM; Bhatti P; Assimes TL
  • Cell-Free DNA Methylation as a Biomarker of Islet-Cell Death in Youth with Type 2 Diabetes
    Volume: 71
    06/01/2022 Authors: Staimez LR; Ham JN; Daley T; Vellanki P; Smith AK; Narayan KMV; Baccarelli A; Conneely K
  • ASSOCIATION OF EARLY LIFE ADVERSITY WITH EPIGENETIC AGE ACCELERATION IN ADULTHOOD
    Volume: 84 Page(s): A149 - A149
    06/01/2022 Authors: Clausing ES; Shelton R; Conneely K; Prada-Ortega D; Factor-Litvak P; Cirillo P; Baccarelli AA; Cohn B; Link B; Suglia SF
  • DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.
    Nat Commun Volume: 13 Page(s): 2408
    05/03/2022 Authors: Wielscher M; Mandaviya PR; Kuehnel B; Joehanes R; Mustafa R; Robinson O; Zhang Y; Bodinier B; Walton E; Mishra PP
  • Methylation quantitative trait loci are largely consistent across disease states in Crohn's disease.
    G3 (Bethesda) Volume: 12
    04/04/2022 Authors: Venkateswaran S; Somineni HK; Kilaru V; Katrinli S; Prince J; Okou DT; Hyams JS; Denson LA; Kellermayer R; Gibson G
  • Brain DNA Methylation Patterns in CLDN5 Associated With Cognitive Decline.
    Biol Psychiatry Volume: 91 Page(s): 389 - 398
    02/15/2022 Authors: Hls A; Robins C; Conneely KN; Edgar R; De Jager PL; Bennett DA; Wingo AP; Epstein MP; Wingo TS
  • Neighborhood characteristics and breast tumor methylation: using epigenomics to explore cancer outcome disparities.
    Breast Cancer Res Treat Volume: 191 Page(s): 653 - 663
    02/01/2022 Authors: Gohar J; Do WL; Miller-Kleinhenz J; Conneely K; Krishnamurti U; D'Angelo O; Gogineni K; Torres M; Gabram-Mendola S; McCullough LE
  • Differential Methylation Analysis for Bisulfite Sequencing (BS-Seq) Data.
    Methods Mol Biol Volume: 2432 Page(s): 211 - 226
    01/01/2022 Authors: Feng H; Conneely K; Wu H
  • Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes.
    Clin Epigenetics Volume: 13 Page(s): 230
    12/22/2021 Authors: Do WL; Nguyen S; Yao J; Guo X; Whitsel EA; Demerath E; Rotter JI; Rich SS; Lange L; Ding J
  • Epigenome-Wide Meta-Analysis of BMI in Nine Cohorts: Examining Methylation as a Biomarker of BMI
    Volume: 29 Page(s): 93 - 93
    12/01/2021 Authors: Do W; Demerath E; Guan W; Li S; Chen W; Sun D; Visscher P; Shah S; Milne R; Dugue P-A
  • Outcomes Stratification of Head and Neck Cancer Using Pre- and Post-Treatment DNA Methylation in Peripheral Blood.
    Int J Radiat Oncol Biol Phys Volume: 111 Page(s): S143 - S144
    11/01/2021 Authors: Qian DC; Ulrich BC; Peng G; Zhao H; Conneely KN; Miller AH; Bruner DW; Eldridge RC; Wommack EC; Higgins KA
  • Examining the association between adiposity and DNA methylation: A systematic review and meta-analysis.
    Obes Rev Volume: 22 Page(s): e13319
    10/01/2021 Authors: Do WL; Gohar J; McCullough LE; Galaviz KI; Conneely KN; Narayan KMV
  • Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study.
    Cancer Volume: 127 Page(s): 3361 - 3371
    09/15/2021 Authors: Xiao C; Beitler JJ; Peng G; Levine ME; Conneely KN; Zhao H; Felger JC; Wommack EC; Chico CE; Jeon S
  • Association of Epigenetic Age Acceleration With Risk Factors, Survival, and Quality of Life in Patients With Head and Neck Cancer.
    Int J Radiat Oncol Biol Phys Volume: 111 Page(s): 157 - 167
    09/01/2021 Authors: Xiao C; Miller AH; Peng G; Levine ME; Conneely KN; Zhao H; Eldridge RC; Wommack EC; Jeon S; Higgins KA
  • Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD.
    Clin Epigenetics Volume: 13 Page(s): 152
    08/05/2021 Authors: Johnson ND; Wu X; Still CD; Chu X; Petrick AT; Gerhard GS; Conneely KN; DiStefano JK
  • Epigenetically mediated electrocardiographic manifestations of sub-chronic exposures to ambient particulate matter air pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.
    Environ Res Volume: 198 Page(s): 111211
    07/01/2021 Authors: Gondalia R; Baldassari A; Holliday KM; Justice AE; Stewart JD; Liao D; Yanosky JD; Engel SM; Sheps D; Jordahl KM
  • Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
    Genome Biol Volume: 22 Page(s): 194
    06/29/2021 Authors: McCartney DL; Min JL; Richmond RC; Lu AT; Sobczyk MK; Davies G; Broer L; Guo X; Jeong A; Jung J
  • Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple Myeloma.
    Clin Cancer Res Volume: 27 Page(s): 3178 - 3189
    06/01/2021 Authors: Barwick BG; Gupta VA; Matulis SM; Patton JC; Powell DR; Gu Y; Jaye DL; Conneely KN; Lin YC; Hofmeister CC
  • The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms.
    Support Care Cancer Volume: 29 Page(s): 3173 - 3182
    06/01/2021 Authors: Xiao C; Fedirko V; Beitler J; Bai J; Peng G; Zhou C; Gu J; Zhao H; Lin I-H; Chico CE
  • Epigenome-wide association study of diet quality in the Women's Health Initiative and TwinsUK cohort.
    Int J Epidemiol Volume: 50 Page(s): 675 - 684
    05/17/2021 Authors: Do WL; Whitsel EA; Costeira R; Masachs OM; Le Roy CI; Bell JT; Staimez LR; Stein AD; Smith AK; Horvath S
  • Polygenic risk scores differentiate schizophrenia patients with toxoplasma gondii compared to toxoplasma seronegative patients.
    Compr Psychiatry Volume: 107 Page(s): 152236
    05/01/2021 Authors: Lori A; Avramopoulos D; Wang AW; Mulle J; Massa N; Duncan EJ; Powers A; Conneely K; Gillespie CF; Jovanovic T
  • Ten-eleven translocation protein 1 modulates medulloblastoma progression.
    Genome Biol Volume: 22 Page(s): 125
    04/29/2021 Authors: Kim H; Kang Y; Li Y; Chen L; Lin L; Johnson ND; Zhu D; Robinson MH; McSwain L; Barwick BG
  • Genome-wide DNA methylation differences and polychlorinated biphenyl (PCB) exposure in a US population.
    Epigenetics Volume: 16 Page(s): 338 - 352
    03/01/2021 Authors: Curtis SW; Cobb DO; Kilaru V; Terrell ML; Marder ME; Barr DB; Marsit CJ; Marcus M; Conneely KN; Smith AK
  • Chromatin Accessibility Identifies Regulatory Elements Predictive of Oncogene Expression in Multiple Myeloma
    Volume: 136
    11/05/2020 Authors: Barwick BG; Gupta VA; Matulis SM; Patton JC; Powell DR; Gu Y; Jaye DL; Conneely KN; Lin YC; Hofmeister CC
  • Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems.
    Epigenomics Volume: 12 Page(s): 1483 - 1499
    09/01/2020 Authors: Justice AE; Chittoor G; Gondalia R; Melton PE; Lim E; Grove ML; Whitsel EA; Liu C-T; Cupples LA; Fernandez-Rhodes L
  • Association between DNA methylation levels in brain tissue and late-life depression in community-based participants.
    Transl Psychiatry Volume: 10 Page(s): 262
    07/30/2020 Authors: Hls A; Robins C; Conneely KN; De Jager PL; Bennett DA; Epstein MP; Wingo TS; Wingo AP
  • Obesity-associated methylation in breast tumors: a possible link to disparate outcomes?
    Breast Cancer Res Treat Volume: 181 Page(s): 135 - 144
    05/01/2020 Authors: Do WL; Conneely K; Gabram-Mendola S; Krishnamurti U; D'Angelo O; Miller-Kleinhenz J; Gogineni K; Torres M; McCullough LE
  • Sex-specific DNA methylation differences in people exposed to polybrominated biphenyl.
    Epigenomics Volume: 12 Page(s): 757 - 770
    05/01/2020 Authors: Curtis SW; Gerkowicz SA; Cobb DO; Kilaru V; Terrell ML; Marder ME; Barr DB; Marsit CJ; Marcus M; Conneely KN
  • RECTAL TISSUE DNA METHYLATION IN ULCERATIVE COLITIS SHOWS DISEASE-SPECIFIC ASSOCIATIONS: INSIGHTS FROM LONGITUDINAL ANALYSIS OF PROTECT STUDY PARTICIPANTS
    Volume: 158 Page(s): S131 - S131
    05/01/2020 Authors: Venkateswaran S; Somineni HK; Matthews J; Kilaru V; Denson LA; Hyams JS; Cutler DJ; Smith AK; Conneely KN; Kugathasan S
  • IN SILICO PREDICTION OF T-CELL-MEDIATED MOLECULAR MIMICRY IN TOXOPLASMOSIS AND SCHIZOPHRENIA
    Volume: 46 Page(s): S108 - S108
    04/01/2020 Authors: Thylur D; Lori A; Avramopoulos D; Mulle J; Goes F; Conneely K; Pulver A; Pearce B
  • Critical evaluation of copy number variant calling methods using DNA methylation.
    Genet Epidemiol Volume: 44 Page(s): 148 - 158
    03/01/2020 Authors: Kilaru V; Knight AK; Katrinli S; Cobb D; Lori A; Gillespie CF; Maihofer AX; Nievergelt CM; Dunlop AL; Conneely KN
  • Age-related DNA hydroxymethylation is enriched for gene expression and immune system processes in human peripheral blood.
    Epigenetics Volume: 15 Page(s): 294 - 306
    03/01/2020 Authors: Johnson ND; Huang L; Li R; Li Y; Yang Y; Kim HR; Grant C; Wu H; Whitsel EA; Kiel DP
  • LONGITUDINAL EVALUATION OF MUCOSAL DNA METHYLATION IN ULCERATIVE COLITIS SHOWS DISEASE-SPECIFIC CHANGES
    Volume: 158 Page(s): S50 - S51
    02/01/2020 Authors: Venkateswaran S; Kilaru V; Somineni H; Matthews J; Hyams J; Cutler D; Smith A; Conneely K; Kugathasan S
  • Endometriosis, endocrine disrupters, and epigenetics: an investigation into the complex interplay in women with polybrominated biphenyl exposure and endometriosis.
    J Assist Reprod Genet Volume: 37 Page(s): 427 - 436
    02/01/2020 Authors: Gerkowicz SA; Curtis SW; Knight AK; Cobb DO; Spencer JB; Conneely KN; Terrell ML; Marcus M; Smith AK
  • LONGITUDINAL EVALUATION OF MUCOSAL DNA METHYLATION IN ULCERATIVE COLITIS SHOWS DISEASE-SPECIFIC CHANGES
    Volume: 26 Page(s): S31 - S32
    01/01/2020 Authors: Venkateswaran S; Kilaru V; Somineni H; Matthews J; Hyams J; Cutler D; Smith A; Conneely K; Kugathasan S
  • Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study.
    Environ Health Perspect Volume: 128 Page(s): 17004
    01/01/2020 Authors: Gondalia R; Holliday KM; Baldassari A; Justice AE; Stewart JD; Liao D; Yanosky JD; Engel SM; Jordahl KM; Bhatti P
  • Associations of Emotion Dysregulation and Complex PTSD With Heart Rate Variability in Trauma-Exposed African American Women With Type 2 Diabetes
    Volume: 44 Page(s): 234 - 235
    12/01/2019 Authors: Powers A; Kim YJ; Michopoulos V; Conneely K; Gluck R; Dixon H; Carter S; Fani N; Pace T; Umpierrez G
  • Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation.
    Environ Int Volume: 132 Page(s): 104723
    11/01/2019 Authors: Gondalia R; Baldassari A; Holliday KM; Justice AE; Mndez-Girldez R; Stewart JD; Liao D; Yanosky JD; Brennan KJM; Engel SM
  • Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking.
    Epigenomics Volume: 11 Page(s): 1487 - 1500
    10/01/2019 Authors: Sikdar S; Joehanes R; Joubert BR; Xu C-J; Vives-Usano M; Rezwan FI; Felix JF; Ward JM; Guan W; Richmond RC
  • Exposure to polybrominated biphenyl and stochastic epigenetic mutations: application of a novel epigenetic approach to environmental exposure in the Michigan polybrominated biphenyl registry.
    Epigenetics Volume: 14 Page(s): 1003 - 1018
    10/01/2019 Authors: Curtis SW; Cobb DO; Kilaru V; Terrell ML; Marder ME; Barr DB; Marsit CJ; Marcus M; Conneely KN; Smith AK
  • Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease.
    Nat Commun Volume: 10 Page(s): 4267
    09/19/2019 Authors: Huan T; Joehanes R; Song C; Peng F; Guo Y; Mendelson M; Yao C; Liu C; Ma J; Richard M
  • Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children.
    Environ Health Volume: 18 Page(s): 75
    08/23/2019 Authors: Curtis SW; Terrell ML; Jacobson MH; Cobb DO; Jiang VS; Neblett MF; Gerkowicz SA; Spencer JB; Marder ME; Barr DB
  • Environmental exposure to polybrominated biphenyl (PBB) associates with an increased rate of biological aging.
    Aging (Albany NY) Volume: 11 Page(s): 5498 - 5517
    08/02/2019 Authors: Curtis SW; Cobb DO; Kilaru V; Terrell ML; Marder ME; Barr DB; Marsit CJ; Marcus M; Conneely KN; Smith AK
  • The differential effects of PTSD, MDD, and dissociation on CRP in trauma-exposed women.
    Compr Psychiatry Volume: 93 Page(s): 33 - 40
    08/01/2019 Authors: Powers A; Dixon HD; Conneely K; Gluck R; Munoz A; Rochat C; Mendoza H; Hartzell G; Ressler KJ; Bradley B
  • Genome-wide association study in two populations to determine genetic variants associated with Toxoplasma gondii infection and relationship to schizophrenia risk.
    Prog Neuropsychopharmacol Biol Psychiatry Volume: 92 Page(s): 133 - 147
    06/08/2019 Authors: Wang AW; Avramopoulos D; Lori A; Mulle J; Conneely K; Powers A; Duncan E; Almli L; Massa N; McGrath J
  • Epigenome-wide Association Study of Diet Quality in the Women's Health Initiative (OR31-06-19).
    Curr Dev Nutr Volume: 3
    06/01/2019 Authors: Leet RW; Whitsel E; Staimez L; Horvath S; Assimes T; Bhatti P; Jordahl K; Narayan KMV; Conneely K
  • Blood-Derived DNA Methylation Signatures of Crohn's Disease and Severity of Intestinal Inflammation.
    Gastroenterology Volume: 156 Page(s): 2254 - 2265.e3
    06/01/2019 Authors: Somineni HK; Venkateswaran S; Kilaru V; Marigorta UM; Mo A; Okou DT; Kellermayer R; Mondal K; Cobb D; Walters TD
  • BLOOD MQTL EFFECTS ARE CONSISTENT DURING THE COURSE OF THE DISEASE REGARDLESS OF REMISSION OR RELAPSE STATUS IN PEDIATRIC CROHN'S DISEASE PATIENTS
    Volume: 156 Page(s): S967 - S967
    05/01/2019 Authors: Venkateswaran S; Somineni HK; Kilaru V; Hyams JS; Denson LA; Cutler DJ; Smith AK; Conneely KN; Kugathasan S
  • The role of DNA methylation and hydroxymethylation in immunosenescence.
    Ageing Res Rev Volume: 51 Page(s): 11 - 23
    05/01/2019 Authors: Johnson ND; Conneely KN
  • LONGITUDINAL MQTL STUDY IN BLOOD FROM PEDIATRIC CROHN'S DISEASE PATIENTS
    Volume: 25 Page(s): S53 - S53
    02/01/2019 Authors: Venkateswaran S; Somineni H; Kilaru V; Cutler D; Smith A; Conneely K; Kugathasan S
  • LONGITUDINAL MQTL STUDY IN BLOOD FROM PEDIATRIC CROHN'S DISEASE PATIENTS
    Volume: 156 Page(s): S75 - S76
    02/01/2019 Authors: Venkateswaran S; Somineni H; Kilaru V; Cutler D; Smith A; Conneely K; Kugathasan S
  • Exposure to polybrominated biphenyl (PBB) associates with genome-wide DNA methylation differences in peripheral blood.
    Epigenetics Volume: 14 Page(s): 52 - 66
    01/01/2019 Authors: Curtis SW; Cobb DO; Kilaru V; Terrell ML; Kennedy EM; Marder ME; Barr DB; Marsit CJ; Marcus M; Conneely KN
  • Robust Rare-Variant Association Tests For Quantitative Traits in General Pedigrees.
    Stat Biosci Volume: 10 Page(s): 491 - 505
    12/01/2018 Authors: Jiang Y; Conneely KN; Epstein MP
  • Identification of the Transcription Factor Relationships Associated with Androgen Deprivation Therapy Response and Metastatic Progression in Prostate Cancer.
    Cancers (Basel) Volume: 10
    10/11/2018 Authors: Sharma NV; Pellegrini KL; Ouellet V; Giuste FO; Ramalingam S; Watanabe K; Adam-Granger E; Fossouo L; You S; Freeman MR
  • Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations.
    Addict Biol Volume: 23 Page(s): 1145 - 1159
    09/01/2018 Authors: Almli LM; Lori A; Meyers JL; Shin J; Fani N; Maihofer AX; Nievergelt CM; Smith AK; Mercer KB; Kerley K
  • Presentation, progression, and predictors of ovarian insufficiency in classic galactosemia.
    J Inherit Metab Dis Volume: 41 Page(s): 785 - 790
    09/01/2018 Authors: Frederick AB; Zinsli AM; Carlock G; Conneely K; Fridovich-Keil JL
  • Transcription factor relationships associated with androgen-deprivation therapy response and metastatic progression in prostate cancer
    Volume: 78
    07/01/2018 Authors: Sharma NV; Pellegrini KL; Ouellet V; Giuste FO; Ramalingam S; Watanabe K; Adam-Granger E; Fossouo L; You S; Freeman MR
  • Powerful and robust cross-phenotype association test for case-parent trios.
    Genet Epidemiol Volume: 42 Page(s): 447 - 458
    07/01/2018 Authors: Fischer ST; Jiang Y; Broadaway KA; Conneely KN; Epstein MP
  • Relationship between Epigenetic Maturity and Respiratory Morbidity in Preterm Infants.
    J Pediatr Volume: 198 Page(s): 168 - 173.e2
    07/01/2018 Authors: Knight AK; Smith AK; Conneely KN; Dalach P; Loke YJ; Cheong JL; Davis PG; Craig JM; Doyle LW; Theda C
  • An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells.
    BMC Genomics Volume: 19 Page(s): 476
    06/19/2018 Authors: Kennedy EM; Goehring GN; Nichols MH; Robins C; Mehta D; Klengel T; Eskin E; Smith AK; Conneely KN
  • Intergenerational effects of endocrine-disrupting compounds: a review of the Michigan polybrominated biphenyl registry.
    Epigenomics Volume: 10 Page(s): 845 - 858
    06/01/2018 Authors: Curtis SW; Conneely KN; Marder ME; Terrell ML; Marcus M; Smith AK
  • HLA typing using genome wide data reveals susceptibility types for infections in a psychiatric disease enriched sample.
    Brain Behav Immun Volume: 70 Page(s): 203 - 213
    05/01/2018 Authors: Parks S; Avramopoulos D; Mulle J; McGrath J; Wang R; Goes FS; Conneely K; Ruczinski I; Yolken R; Pulver AE
  • EPIGENOME-WIDE ASSOCIATION STUDY IDENTIFIED SHARED METHYLOMIC CONTRIBUTIONS TO SUSCEPTIBILITY AND PROGRESSION IN PEDIATRIC CROHN'S DISEASE
    Volume: 154 Page(s): S1022 - S1022
    05/01/2018 Authors: Somineni HK; Kilaru V; Venkateswaran S; Marigorta U; Mondal K; Chopra P; Okou D; Hyams JS; Denson LA; Cutler DJ
  • Galactic Cosmic Radiation Induces Persistent Epigenome Alterations Relevant to Human Lung Cancer.
    Sci Rep Volume: 8 Page(s): 6709
    04/30/2018 Authors: Kennedy EM; Powell DR; Li Z; Bell JSK; Barwick BG; Feng H; McCrary MR; Dwivedi B; Kowalski J; Dynan WS
  • A Multi-pollutant, Multi-ethnic, and Methylome-wide Association Study Highlights Epigenetic Effects of Exposure to Ambient Air Pollution Mixtures
    Volume: 137
    03/20/2018 Authors: Baldassari AR; Gondalia R; Holliday KM; Mendez-Giraldez R; Justice AE; Stewart JD; Yanosky JD; Liao D; Tinker L; Jordhal KM
  • Methylome-wide Association Study Provides Evidence of Particulate Matter Air Pollution-associated Dna Methylation at Cardiovascular Disease-related Genes
    Volume: 137
    03/20/2018 Authors: Gondalia R; Baldassari AR; Holliday KM; Mendez-Giraldez R; Justice AE; Stewart JD; Liao D; Yanosky JD; Jordhal KM; Bhatti P
  • Kernel machine methods for integrative analysis of genome-wide methylation and genotyping studies.
    Genet Epidemiol Volume: 42 Page(s): 156 - 167
    03/01/2018 Authors: Zhao N; Zhan X; Huang Y-T; Almli LM; Smith A; Epstein MP; Conneely K; Wu MC
  • Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD.
    Mol Psychiatry Volume: 23 Page(s): 658 - 665
    03/01/2018 Authors: Maddox SA; Kilaru V; Shin J; Jovanovic T; Almli LM; Dias BG; Norrholm SD; Fani N; Michopoulos V; Ding Z
  • A DNA methylation biomarker of alcohol consumption.
    Mol Psychiatry Volume: 23 Page(s): 422 - 433
    02/01/2018 Authors: Liu C; Marioni RE; Hedman K; Pfeiffer L; Tsai P-C; Reynolds LM; Just AC; Duan Q; Boer CG; Tanaka T
  • EPIGENOME-WIDE ASSOCIATION STUDY IDENTIFIED SHARED METHYLOMIC CONTRIBUTIONS TO SUSCEPTIBILITY AND PROGRESSION IN PEDIATRIC CROHN'S DISEASE
    Volume: 24 Page(s): S71 - S71
    02/01/2018 Authors: Somineni HK; Venkateswaran S; Kilaru V; Chopra P; Okou DT; Hyams JS; Denson LA; Cutler DJ; Gibson G; Conneely KN
  • EPIGENOME-WIDE ASSOCIATION STUDY IDENTIFIED SHARED METHYLOMIC CONTRIBUTIONS TO SUSCEPTIBILITY AND PROGRESSION IN PEDIATRIC CROHN'S DISEASE
    Volume: 154 Page(s): S101 - S101
    01/01/2018 Authors: Somineni HK; Venkateswaran S; Kilaru V; Chopra P; Okou DT; Hyams JS; Denson LA; Cutler DJ; Gibson G; Conneely KN
  • SLC9B1 methylation predicts fetal intolerance of labor.
    Epigenetics Volume: 13 Page(s): 33 - 39
    01/01/2018 Authors: Knight AK; Conneely KN; Kilaru V; Cobb D; Payne JL; Meilman S; Corwin EJ; Kaminsky ZA; Dunlop AL; Smith AK
  • Characterization of gene expression changes over healthy term pregnancies.
    PLoS One Volume: 13 Page(s): e0204228
    01/01/2018 Authors: Knight AK; Dunlop AL; Kilaru V; Cobb D; Corwin EJ; Conneely KN; Smith AK
  • A longitudinal study of DNA methylation as a potential mediator of age-related diabetes risk.
    Geroscience Volume: 39 Page(s): 475 - 489
    12/01/2017 Authors: Grant CD; Jafari N; Hou L; Li Y; Stewart JD; Zhang G; Lamichhane A; Manson JE; Baccarelli AA; Whitsel EA
  • Testing Two Evolutionary Theories of Human Aging with DNA Methylation Data.
    Genetics Volume: 207 Page(s): 1547 - 1560
    12/01/2017 Authors: Robins C; McRae AF; Powell JE; Wiener HW; Aslibekyan S; Kennedy EM; Absher DM; Arnett DK; Montgomery GW; Visscher PM
  • PROBLEMATIC ALCOHOL USE BEHAVIOR COMORBIDITY IN A HIGHLY TRAUMATIZED URBAN COHORT AND ITS GWAS ASSOCIATION WITH AN EQTL OF THE SCLT1 GENE
    Volume: 27 Page(s): S135 - S136
    10/01/2017 Authors: Almli L; Tang Y; Meyers J; Koenen K; Marmar C; Shin J; Maihofer A; Nievergelt C; Conneely K; Ressler K
  • Serum Polybrominated Biphenyls (PBBs) and Polychlorinated Biphenyls (PCBs) and Thyroid Function among Michigan Adults Several Decades after the 1973-1974 PBB Contamination of Livestock Feed.
    Environ Health Perspect Volume: 125 Page(s): 097020
    09/26/2017 Authors: Jacobson MH; Darrow LA; Barr DB; Howards PP; Lyles RH; Terrell ML; Smith AK; Conneely KN; Marder ME; Marcus M
  • Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits.
    Genetics Volume: 206 Page(s): 1779 - 1790
    08/01/2017 Authors: Zhan X; Zhao N; Plantinga A; Thornton TA; Conneely KN; Epstein MP; Wu MC
  • Non-linear patterns in age-related DNA methylation may reflect CD4+ T cell differentiation.
    Epigenetics Volume: 12 Page(s): 492 - 503
    06/03/2017 Authors: Johnson ND; Wiener HW; Smith AK; Nishitani S; Absher DM; Arnett DK; Aslibekyan S; Conneely KN
  • Gestational age predicted by DNA methylation: potential clinical and research utility.
    Epigenomics
    01/23/2017 Authors: Knight AK; Conneely KN; Smith AK
  • Methylation of slc9b1 predicts fetal intolerance of labor
    Volume: 216 Page(s): S148 - S148
    01/01/2017 Authors: Knight AK; Conneely KN; Kilaru V; Cobb D; Payne JL; Meilman S; Corwin EJ; Kaminsky ZA; Dunlop AL; Smith AK
  • Case-control Association Study of Autoimmunity Associated Variants in PDCD1 and Juvenile Idiopathic Arthritis.
    Curr Rheumatol Rev Volume: 13 Page(s): 219 - 223
    01/01/2017 Authors: Tejeda C; Broadaway AK; Ombrello MJ; Brown MR; Ponder LA; Pichavant MR; Wang G; Angeles-Han S; Hersh A; Bohnsack J
  • DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.
    Genome Biol Volume: 17 Page(s): 255
    12/12/2016 Authors: Ligthart S; Marzi C; Aslibekyan S; Mendelson MM; Conneely KN; Tanaka T; Colicino E; Waite LL; Joehanes R; Guan W
  • Prioritizing individual genetic variants after kernel machine testing using variable selection.
    Genet Epidemiol Volume: 40 Page(s): 722 - 731
    12/01/2016 Authors: He Q; Cai T; Liu Y; Zhao N; Harmon QE; Almli LM; Binder EB; Engel SM; Ressler KJ; Conneely KN
  • Epigenetic Signatures of Cigarette Smoking
    CIRCULATION Volume: 134 Page(s): 1682 - 1682
    11/22/2016 Authors: Joehanes R; Just AC; Marioni RE; Pilling LC; Reynolds LM; Mandaviya PR; Guan W; Xu T; Elks CE; Aslibekyan S
  • INTERPLAY BETWEEN MULTIPLE EPIGENETIC MECHANISMS AND GENE EXPRESSION IN HUMAN AGING
    GERONTOLOGIST Volume: 56 Page(s): 35 - 35
    11/01/2016 Authors: Conneely KN; Jin P; Wu H; Grant C; Brennan K; Murabito JM; Baccarelli A
  • An epigenetic clock for gestational age at birth based on blood methylation data
    BREAST CANCER RESEARCH Volume: 17
    10/07/2016 Authors: Knight AK; Craig JM; Theda C; Baekvad-Hansen M; Bybjerg-Grauholm J; Hansen CS; Hollegaard MV; Hougaard DM; Mortensen PB; Weinsheimer SM
  • An epigenetic clock for gestational age at birth based on blood methylation data.
    Genome Biol Volume: 17 Page(s): 206
    10/07/2016 Authors: Knight AK; Craig JM; Theda C; Bkvad-Hansen M; Bybjerg-Grauholm J; Hansen CS; Hollegaard MV; Hougaard DM; Mortensen PB; Weinsheimer SM
  • Epigenetic Signatures of Cigarette Smoking.
    Circ Cardiovasc Genet Volume: 9 Page(s): 436 - 447
    10/01/2016 Authors: Joehanes R; Just AC; Marioni RE; Pilling LC; Reynolds LM; Mandaviya PR; Guan W; Xu T; Elks CE; Aslibekyan S
  • Statistical challenges in analyzing methylation and long-range chromosomal interaction data.
    Stat Biosci Volume: 8 Page(s): 284 - 309
    10/01/2016 Authors: Qin Z; Li B; Conneely KN; Wu H; Hu M; Ayyala D; Park Y; Jin VX; Zhang F; Zhang H
  • Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder.
    Transl Psychiatry Volume: 6 Page(s): e820
    05/24/2016 Authors: Kilaru V; Iyer SV; Almli LM; Stevens JS; Lori A; Jovanovic T; Ely TD; Bradley B; Binder EB; Koen N
  • An Epigenetic Clock for Developmental Maturity at Birth
    Volume: 79 Page(s): 123S - 123S
    05/01/2016 Authors: Knight AK; Binder EB; Iurato S; Horvath S; Conneely KN; Smith AK
  • Across-Platform Imputation of DNA Methylation Levels Incorporating Nonlocal Information Using Penalized Functional Regression.
    Genet Epidemiol Volume: 40 Page(s): 333 - 340
    05/01/2016 Authors: Zhang G; Huang K-C; Xu Z; Tzeng J-Y; Conneely KN; Guan W; Kang J; Li Y
  • Phenotypic Characterization of Juvenile Idiopathic Arthritis in African American Children.
    Volume: 43 Page(s): 799 - 803
    04/01/2016 Authors: Fitzpatrick L; Broadaway KA; Ponder L; Angeles-Han ST; Jenkins K; Rouster-Stevens K; Pelajo CF; Conneely K; Epstein MP; Lopez-Benitez J
  • Autosomal Dominant Retinal Dystrophies Caused by a Founder Splice Site Mutation, c.828+3A>T, in PRPH2 and Protein Haplotypes in trans as Modifiers.
    Invest Ophthalmol Vis Sci Volume: 57 Page(s): 349 - 359
    02/01/2016 Authors: Shankar SP; Hughbanks-Wheaton DK; Birch DG; Sullivan LS; Conneely KN; Bowne SJ; Stone EM; Daiger SP
  • Fatigue is associated with inflammation in patients with head and neck cancer before and after intensity-modulated radiation therapy.
    Brain Behav Immun Volume: 52 Page(s): 145 - 152
    02/01/2016 Authors: Xiao C; Beitler JJ; Higgins KA; Conneely K; Dwivedi B; Felger J; Wommack EC; Shin DM; Saba NF; Ong LY
  • Emotion Dysregulation and Inflammation in African-American Women with Type 2 Diabetes.
    Neural Plast Volume: 2016 Page(s): 8926840
    01/01/2016 Authors: Powers A; Michopoulos V; Conneely K; Gluck R; Dixon H; Wilson J; Jovanovic T; Pace TWW; Umpierrez GE; Ressler KJ
  • Oxytocin Receptor Genetic and Epigenetic Variations: Association With Child Abuse and Adult Psychiatric Symptoms.
    Child Dev Volume: 87 Page(s): 122 - 134
    01/01/2016 Authors: Smearman EL; Almli LM; Conneely KN; Brody GH; Sales JM; Bradley B; Ressler KJ; Smith AK
  • Detection of differentially methylated regions from whole-genome bisulfite sequencing data without replicates.
    Nucleic Acids Res Volume: 43 Page(s): e141
    12/02/2015 Authors: Wu H; Xu T; Feng H; Chen L; Li B; Yao B; Qin Z; Jin P; Conneely KN
  • The transcriptional landscape of age in human peripheral blood.
    Nat Commun Volume: 6 Page(s): 8570
    10/22/2015 Authors: Peters MJ; Joehanes R; Pilling LC; Schurmann C; Conneely KN; Powell J; Reinmaa E; Sutphin GL; Zhernakova A; Schramm K
  • Kernel Approach for Modeling Interaction Effects in Genetic Association Studies of Complex Quantitative Traits.
    Genet Epidemiol Volume: 39 Page(s): 366 - 375
    10/01/1997 Authors: Broadaway KA; Duncan R; Conneely KN; Almli LM; Bradley B; Ressler KJ; Epstein MP
  • Drug Metabolizing Enzyme and Transporter Gene Variation, Nicotine Metabolism, Prospective Abstinence, and Cigarette Consumption.
    PLoS One Volume: 10 Page(s): e0126113
    01/01/2015 Authors: Bergen AW; Michel M; Nishita D; Krasnow R; Javitz HS; Conneely KN; Lessov-Schlaggar CN; Hops H; Zhu AZX; Baurley JW
  • DNA methylation provides insight into intergenerational risk for preterm birth in African Americans.
    Epigenetics Volume: 10 Page(s): 784 - 792
    01/01/2015 Authors: Parets SE; Conneely KN; Kilaru V; Menon R; Smith AK
  • DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain.
    Am J Med Genet B Neuropsychiatr Genet Volume: 168B Page(s): 36 - 44
    01/01/2015 Authors: Smith AK; Kilaru V; Klengel T; Mercer KB; Bradley B; Conneely KN; Ressler KJ; Binder EB
  • Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation.
    PLoS One Volume: 10 Page(s): e0116696
    01/01/2015 Authors: Avramopoulos D; Pearce BD; McGrath J; Wolyniec P; Wang R; Eckart N; Hatzimanolis A; Goes FS; Nestadt G; Mulle J
  • HDAC4 Regulation in Women with PTSD: Evidence from Human and Animal Models
    Volume: 39 Page(s): S471 - S471
    12/01/2014 Authors: Smith A; Maddox S; Almli L; Diaz B; Conneely K; Kilaru V; Binder E; Ressler K
  • Problematic Alcohol Behavior and Related Neural Phenotypes Are Associated with an Expression QTL of the Sodium Channel and Clathrin Linker 1 (SCLT1) Gene
    Volume: 39 Page(s): S406 - S406
    12/01/2014 Authors: Ressler K; Almli L; Meyers J; Shin J; Fani N; Conneely K; Maihofer A; Nievergelt C; Abu-Amara D; Yehuda R
  • Correcting systematic inflation in genetic association tests that consider interaction effects: application to a genome-wide association study of posttraumatic stress disorder.
    JAMA Psychiatry Volume: 71 Page(s): 1392 - 1399
    12/01/2014 Authors: Almli LM; Duncan R; Feng H; Ghosh D; Binder EB; Bradley B; Ressler KJ; Conneely KN; Epstein MP
  • Testing evolutionary models of senescence: traditional approaches and future directions.
    Hum Genet Volume: 133 Page(s): 1451 - 1465
    12/01/2014 Authors: Robins C; Conneely KN
  • Flexible and robust methods for rare-variant testing of quantitative traits in trios and nuclear families.
    Genet Epidemiol Volume: 38 Page(s): 542 - 551
    09/01/2014 Authors: Jiang Y; Conneely KN; Epstein MP
  • Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy.
    Brain Behav Immun Volume: 38 Page(s): 227 - 236
    05/01/2014 Authors: Smith AK; Conneely KN; Pace TWW; Mister D; Felger JC; Kilaru V; Akel MJ; Vertino PM; Miller AH; Torres MA
  • Dissecting vancomycin-intermediate resistance in staphylococcus aureus using genome-wide association.
    Genome Biol Evol Volume: 6 Page(s): 1174 - 1185
    04/30/2014 Authors: Alam MT; Petit RA; Crispell EK; Thornton TA; Conneely KN; Jiang Y; Satola SW; Read TD
  • Accounting for population stratification in DNA methylation studies.
    Genet Epidemiol Volume: 38 Page(s): 231 - 241
    01/01/2014 Authors: Barfield RT; Almli LM; Kilaru V; Smith AK; Mercer KB; Duncan R; Klengel T; Mehta D; Binder EB; Epstein MP
  • A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data.
    Nucleic Acids Res Volume: 42 Page(s): e69
    04/01/2014 Authors: Feng H; Conneely KN; Wu H
  • Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type.
    BMC Genomics Volume: 15 Page(s): 145
    02/21/2014 Authors: Smith AK; Kilaru V; Kocak M; Almli LM; Mercer KB; Ressler KJ; Tylavsky FA; Conneely KN
  • Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills.
    Proc Natl Acad Sci U S A Volume: 111 Page(s): 1987 - 1992
    02/04/2014 Authors: Skuse DH; Lori A; Cubells JF; Lee I; Conneely KN; Puura K; Lehtimki T; Binder EB; Young LJ
  • Tandem repeats and G-rich sequences are enriched at human CNV breakpoints.
    PLoS One Volume: 9 Page(s): e101607
    01/01/2014 Authors: Bose P; Hermetz KE; Conneely KN; Rudd MK
  • Large inverted duplications in the human genome form via a fold-back mechanism.
    PLoS Genet Volume: 10 Page(s): e1004139
    01/01/2014 Authors: Hermetz KE; Newman S; Conneely KN; Martin CL; Ballif BC; Shaffer LG; Cody JD; Rudd MK
  • The Utility of DNA Extracted from Saliva for Methylation Studies of Psychiatric Traits
    Volume: 38 Page(s): S488 - S489
    12/01/2013 Authors: Smith AK; Kilaru V; Klengel T; Mercer KB; Conneely K; Ressler KJ; Binder E
  • Vitamin D status and bone mineral density in African American children with Crohn disease.
    J Pediatr Gastroenterol Nutr Volume: 57 Page(s): 587 - 593
    11/01/2013 Authors: Middleton JP; Bhagavathula AP; Gaye B; Alvarez JA; Huang CS; Sauer CG; Tenjarla G; Schoen BT; Kumar A; Prasad M
  • Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA.
    Pediatr Rheumatol Online J Volume: 11 Page(s): 40
    10/25/2013 Authors: Kaalla MJ; Broadaway KA; Rohani-Pichavant M; Conneely KN; Whiting A; Ponder L; Okou DT; Angeles-Han S; Rouster-Stevens K; Brown MR
  • Mouse model implicates GNB3 duplication in a childhood obesity syndrome.
    Proc Natl Acad Sci U S A Volume: 110 Page(s): 14990 - 14994
    09/01/2013 Authors: Goldlust IS; Hermetz KE; Catalano LM; Barfield RT; Cozad R; Wynn G; Ozdemir AC; Conneely KN; Mulle JG; Dharamrup S
  • Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans.
    Hum Genet Volume: 132 Page(s): 1027 - 1037
    09/01/2013 Authors: Sun YV; Smith AK; Conneely KN; Chang Q; Li W; Lazarus A; Smith JA; Almli LM; Binder EB; Klengel T
  • Susceptibility to childhood-onset rheumatoid arthritis: investigation of a weighted genetic risk score that integrates cumulative effects of variants at five genetic loci.
    Arthritis Rheum Volume: 65 Page(s): 1663 - 1667
    06/01/2013 Authors: Prahalad S; Conneely KN; Jiang Y; Sudman M; Wallace CA; Brown MR; Ponder LA; Rohani-Pichavant M; Zwick ME; Cutler DJ
  • Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder.
    Proc Natl Acad Sci U S A Volume: 110 Page(s): 8302 - 8307
    05/14/2013 Authors: Mehta D; Klengel T; Conneely KN; Smith AK; Altmann A; Pace TW; Rex-Haffner M; Loeschner A; Gonik M; Mercer KB
  • ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females.
    Am J Med Genet B Neuropsychiatr Genet Volume: 162B Page(s): 262 - 272
    04/01/2013 Authors: Almli LM; Mercer KB; Kerley K; Feng H; Bradley B; Conneely KN; Ressler KJ
  • Sex dependent influence of a functional polymorphism in steroid 5--reductase type 2 (SRD5A2) on post-traumatic stress symptoms.
    Am J Med Genet B Neuropsychiatr Genet Volume: 162B Page(s): 283 - 292
    04/01/2013 Authors: Gillespie CF; Almli LM; Smith AK; Bradley B; Kerley K; Crain DF; Mercer KB; Weiss T; Phifer J; Tang Y
  • DNA Methylation Differences in Umbilical Cord Blood from a Preterm Birth Population
    Volume: 20 Page(s): 123A - 123A
    03/01/2013 Authors: Parets SE; Conneely KN; Kilaru V; Syed TA; Saade G; Smith AK; Menon R
  • Replication of Gestational Age Dependent DNA Methylation Differences in a Preterm Birth Cohort
    Volume: 20 Page(s): 157A - 157A
    03/01/2013 Authors: Smith AK; Parets SE; Conneely KN; Kilaru V; Syed TA; Saade G; Menon R
  • Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus.
    BMC Med Genet Volume: 14 Page(s): 18
    01/29/2013 Authors: Alisch RS; Wang T; Chopra P; Visootsak J; Conneely KN; Warren ST
  • Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen.
    Hum Mol Genet Volume: 22 Page(s): 1 - 17
    01/01/2013 Authors: Schwarze U; Cundy T; Pyott SM; Christiansen HE; Hegde MR; Bank RA; Pals G; Ankala A; Conneely K; Seaver L
  • Differential Genetic and Epigenetic Regulation of catechol-O-methyltransferase is Associated with Impaired Fear Inhibition in Posttraumatic Stress Disorder.
    Front Behav Neurosci Volume: 7 Page(s): 30
    01/01/2013 Authors: Norrholm SD; Jovanovic T; Smith AK; Binder E; Klengel T; Conneely K; Mercer KB; Davis JS; Kerley K; Winkler J
  • Assessing the impact of population stratification on association studies of rare variation.
    Hum Hered Volume: 76 Page(s): 28 - 35
    01/01/2013 Authors: Jiang Y; Epstein MP; Conneely KN
  • Fetal DNA Methylation Associates with Early Spontaneous Preterm Birth and Gestational Age.
    PLoS One Volume: 8 Page(s): e67489
    01/01/2013 Authors: Parets SE; Conneely KN; Kilaru V; Fortunato SJ; Syed TA; Saade G; Smith AK; Menon R
  • A permutation procedure to correct for confounders in case-control studies, including tests of rare variation.
    Am J Hum Genet Volume: 91 Page(s): 215 - 223
    08/10/2012 Authors: Epstein MP; Duncan R; Jiang Y; Conneely KN; Allen AS; Satten GA
  • Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence.
    Genome Res Volume: 22 Page(s): 1395 - 1406
    08/01/2012 Authors: Gordon L; Joo JE; Powell JE; Ollikainen M; Novakovic B; Li X; Andronikos R; Cruickshank MN; Conneely KN; Smith AK
  • Human longevity and common variations in the LMNA gene: a meta-analysis.
    Aging Cell Volume: 11 Page(s): 475 - 481
    06/01/2012 Authors: Conneely KN; Capell BC; Erdos MR; Sebastiani P; Solovieff N; Swift AJ; Baldwin CT; Budagov T; Barzilai N; Atzmon G
  • CpGassoc: an R function for analysis of DNA methylation microarray data.
    Bioinformatics Volume: 28 Page(s): 1280 - 1281
    05/01/2012 Authors: Barfield RT; Kilaru V; Smith AK; Conneely KN
  • Prenatal antiepileptic exposure associates with neonatal DNA methylation differences.
    Epigenetics Volume: 7 Page(s): 458 - 463
    05/01/2012 Authors: Smith AK; Conneely KN; Newport DJ; Kilaru V; Schroeder JW; Pennell PB; Knight BT; Cubells JC; Stowe ZN; Brennan PA
  • Age-associated DNA methylation in pediatric populations.
    Genome Res Volume: 22 Page(s): 623 - 632
    04/01/2012 Authors: Alisch RS; Barwick BG; Chopra P; Myrick LK; Satten GA; Conneely KN; Warren ST
  • DNA methylation in neonates born to women receiving psychiatric care.
    Epigenetics Volume: 7 Page(s): 409 - 414
    04/01/2012 Authors: Schroeder JW; Smith AK; Brennan PA; Conneely KN; Kilaru V; Knight BT; Newport DJ; Cubells JF; Stowe ZN
  • MethLAB: a graphical user interface package for the analysis of array-based DNA methylation data.
    Epigenetics Volume: 7 Page(s): 225 - 229
    03/01/2012 Authors: Kilaru V; Barfield RT; Schroeder JW; Smith AK; Conneely KN
  • Hierarchy of risk of childhood-onset rheumatoid arthritis conferred by HLA-DRB1 alleles encoding the shared epitope.
    Arthritis Rheum Volume: 64 Page(s): 925 - 930
    03/01/2012 Authors: Prahalad S; Thompson SD; Conneely KN; Jiang Y; Leong T; Prozonic J; Brown MR; Ponder LA; Angeles-Han ST; Vogler LB
  • A Novel Permutation Strategy to Correct for Population Stratification in Case-Control Studies of Rare Variation
    Volume: 36 Page(s): 124 - 124
    02/01/2012 Authors: Epstein MP; Jiang Y; Conneely KN; Duncan R; Allen AS; Satten GA
  • Acute and posttraumatic stress symptoms in a prospective gene x environment study of a university campus shooting.
    Arch Gen Psychiatry Volume: 69 Page(s): 89 - 97
    01/01/2012 Authors: Mercer KB; Orcutt HK; Quinn JF; Fitzgerald CA; Conneely KN; Barfield RT; Gillespie CF; Ressler KJ
  • DNA methylation: an epigenetic risk factor in preterm birth.
    Reprod Sci Volume: 19 Page(s): 6 - 13
    01/01/2012 Authors: Menon R; Conneely KN; Smith AK
  • Neonatal DNA methylation patterns associate with gestational age.
    Epigenetics Volume: 6 Page(s): 1498 - 1504
    12/01/2011 Authors: Schroeder JW; Conneely KN; Cubells JC; Kilaru V; Newport DJ; Knight BT; Stowe ZN; Brennan PA; Krushkal J; Tylavsky FA
  • Genetic variants of -synuclein are not associated with essential tremor.
    Mov Disord Volume: 26 Page(s): 2552 - 2556
    12/01/2011 Authors: Ross OA; Conneely KN; Wang T; Vilarino-Guell C; Soto-Ortolaza AI; Rajput A; Wszolek ZK; Uitti RJ; Louis ED; Clark LN
  • Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder.
    Am J Med Genet B Neuropsychiatr Genet Volume: 156B Page(s): 700 - 708
    09/01/2011 Authors: Smith AK; Conneely KN; Kilaru V; Mercer KB; Weiss TE; Bradley B; Tang Y; Gillespie CF; Cubells JF; Ressler KJ
  • The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment.
    Neuropsychopharmacology Volume: 36 Page(s): 1412 - 1420
    06/01/2011 Authors: Lori A; Tang Y; O'Malley S; Picciotto MR; Wu R; Conneely KN; Cubells JF
  • Meta-analysis of genetic association studies and adjustment for multiple testing of correlated SNPs and traits.
    Genet Epidemiol Volume: 34 Page(s): 739 - 746
    11/01/2010 Authors: Conneely KN; Boehnke M
  • Association between DNA Methylation Patterns and Total Life Stress in Inner City Primary Care Patients
    Volume: 67 Page(s): 147S - 147S
    05/01/2010 Authors: Smith AK; Kilaru V; Conneely KN; Gillespie CF; Mercer KB; Weiss TE; Bradley-Davino B; Tang Y; Cubells JF; Ressler KJ
  • Trauma Exposure and Stress-Related Disorders in Inner City Primary Care Patients
    Volume: 65 Page(s): 118S - 118S
    04/15/2009 Authors: Gillespie CF; Bradley RG; Mercer K; Smith AK; Conneely K; Gapen M; Weiss T; Schwartz AC; Cubells JF; Ressler KJ
  • Trauma exposure and stress-related disorders in inner city primary care patients.
    Gen Hosp Psychiatry Volume: 31 Page(s): 505 - 514
    01/01/2009 Authors: Gillespie CF; Bradley B; Mercer K; Smith AK; Conneely K; Gapen M; Weiss T; Schwartz AC; Cubells JF; Ressler KJ
  • Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.
    Diabetes Volume: 57 Page(s): 3136 - 3144
    11/01/2008 Authors: Gaulton KJ; Willer CJ; Li Y; Scott LJ; Conneely KN; Jackson AU; Duren WL; Chines PS; Narisu N; Bonnycastle LL
  • A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model.
    Proc Natl Acad Sci U S A Volume: 105 Page(s): 15902 - 15907
    10/14/2008 Authors: Capell BC; Olive M; Erdos MR; Cao K; Faddah DA; Tavarez UL; Conneely KN; Qu X; San H; Ganesh SK
  • So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests.
    Am J Hum Genet Volume: 81 Page(s): 1158 - 1168
    12/01/2007 Authors: Conneely KN; Boehnke M
  • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
    Science Volume: 316 Page(s): 1341 - 1345
    06/01/2007 Authors: Scott LJ; Mohlke KL; Bonnycastle LL; Willer CJ; Li Y; Duren WL; Erdos MR; Stringham HM; Chines PS; Jackson AU
  • Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.
    Diabetes Volume: 56 Page(s): 256 - 264
    01/01/2007 Authors: Willer CJ; Bonnycastle LL; Conneely KN; Duren WL; Jackson AU; Scott LJ; Narisu N; Chines PS; Skol A; Stringham HM
  • Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q.
    Hum Hered Volume: 63 Page(s): 17 - 25
    01/01/2007 Authors: Shtir C; Nagakawa IS; Duren WL; Conneely KN; Scott LJ; Silander K; Valle TT; Tuomilehto J; Buchanan TA; Bergman RN
  • Common variants in maturity-onset diabetes of the young genes contribute to risk of type 2 diabetes in Finns.
    Diabetes Volume: 55 Page(s): 2534 - 2540
    09/01/2006 Authors: Bonnycastle LL; Willer CJ; Conneely KN; Jackson AU; Burrill CP; Watanabe RM; Chines PS; Narisu N; Scott LJ; Enloe ST
  • Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns.
    Hum Genet Volume: 118 Page(s): 245 - 254
    11/01/2005 Authors: Mohlke KL; Jackson AU; Scott LJ; Peck EC; Suh YD; Chines PS; Watanabe RM; Buchanan TA; Conneely KN; Erdos MR
  • Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.
    Proc Natl Acad Sci U S A Volume: 102 Page(s): 12879 - 12884
    09/06/2005 Authors: Capell BC; Erdos MR; Madigan JP; Fiordalisi JJ; Varga R; Conneely KN; Gordon LB; Der CJ; Cox AD; Collins FS
  • Evidence for two distinct type 2 diabetes Mellitus/Obesity loci on chromosome 11q23: Replication in ethnically diverse populations
    Volume: 54 Page(s): A32 - A32
    01/01/2005 Authors: Baier L; Muller Y; Ma L; Traurig M; Bottner A; Stone S; Timms K; Groves CJ; McCarthy MI; Mike E
  • Type 2 diabetes (T2D) and quantitative trait association analysis of a Finnish sample with SNPs previously reported to be associated with T2D
    Volume: 54 Page(s): A43 - A43
    01/01/2005 Authors: Bonnycastle LL; Willer CJ; Jackson AU; Conneely KN; Mohlke KL; Scott LJ; Narisu N; Chines PS; Erdos MR; Valle TT
  • Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects.
    Diabetologia Volume: 47 Page(s): 1782 - 1788
    10/01/2004 Authors: Conneely KN; Silander K; Scott LJ; Mohlke KL; Lazaridis KN; Valle TT; Tuomilehto J; Bergman RN; Watanabe RM; Buchanan TA
  • Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.
    Diabetes Volume: 53 Page(s): 1141 - 1149
    04/01/2004 Authors: Silander K; Mohlke KL; Scott LJ; Peck EC; Hollstein P; Skol AD; Jackson AU; Deloukas P; Hunt S; Stavrides G
  • Variation in the resistin gene is associated with diabetes-related phenotypes in Finns
    Volume: 73 Page(s): 383 - 383
    11/01/2003 Authors: Conneely KN; Silander K; Lazaridis KN; Mohlke KL; Scott LJ; Valle TT; Watanabe RM; Buchanan TA; Bergman RN; Tuomilehto J
  • Sampling bias-in the D ' statistic and a bootstrap correction.
    Volume: 71 Page(s): 573 - 573
    10/01/2002 Authors: Conneely KN; Abecasis GR; Boehnke M
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