Kevin Bunting PhD

Department of Pediatrics
Professor

Aflac Cancer & Blood Disorders Center
Pediatrics
1760 Haygood Drive NE

Academic Appointment

Professor of Pediatrics, Emory University

Education

Degrees

PhD from Wake Forest University, Bowman Gray School of Medicine
BS from Pfeiffer College

Research

Focus

The research focus of my lab is on understanding the molecular mechanisms responsible for blood cell development. This research area includes studies of hematopoietic stem cell biology, hematopoiesis, and the changes that occur during leukemogenesis. The main goal of our work is to improve upon therapeutics for treating hematologic disorders.

Publications

A genetic association study of circulating coagulation factor VIII and von Willebrand factor levels.
Blood Volume: 143 Page(s): 1845 - 1855
05/02/2024 Authors: de Vries PS; Reventun P; Brown MR; Heath AS; Huffman JE; Le N-Q; Bebo A; Brody JA; Temprano-Sagrera G; Raffield LM
Stromal STAT5-Mediated Trophic Activity Regulates Hematopoietic Niche Factors.
Stem Cells Volume: 41 Page(s): 944 - 957
10/08/2023 Authors: Wang Z; Emmel G; Lim HS; Zhu W; Kosters A; Ghosn EEB; Qiu P; Bunting KD
Author Correction: Clonal haematopoiesis and risk of chronic liver disease.
Nature Volume: 619 Page(s): E47
07/01/2023 Authors: Wong WJ; Emdin C; Bick AG; Zekavat SM; Niroula A; Pirruccello JP; Dichtel L; Griffin G; Uddin MM; Gibson CJ
Clonal haematopoiesis and risk of chronic liver disease.
Nature Volume: 616 Page(s): 747 - 754
04/01/2023 Authors: Wong WJ; Emdin C; Bick AG; Zekavat SM; Niroula A; Pirruccello JP; Dichtel L; Griffin G; Uddin MM; Gibson CJ
Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.
Nat Commun Volume: 13 Page(s): 4923
08/22/2022 Authors: Tahir UA; Katz DH; Avila-Pachecho J; Bick AG; Pampana A; Robbins JM; Yu Z; Chen Z-Z; Benson MD; Cruz DE
JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1.
Blood Adv Volume: 6 Page(s): 200 - 206
01/11/2022 Authors: Yan Y; Dong L; Chen C; Bunting KD; Li Q; Stieglitz E; Loh ML; Qu C-K
Pimozide and Imipramine Blue Exploit Mitochondrial Vulnerabilities and Reactive Oxygen Species to Cooperatively Target High Risk Acute Myeloid Leukemia.
Antioxidants (Basel) Volume: 10
06/15/2021 Authors: Wang Z; Mi T; Bradley HL; Metts J; Sabnis H; Zhu W; Arbiser J; Bunting KD
Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation.
Front Immunol Volume: 10 Page(s): 486
01/01/2019 Authors: Wang Z; Vaughan TY; Zhu W; Chen Y; Fu G; Medrzycki M; Nishio H; Bunting ST; Hankey-Giblin PA; Nusrat A
The Cooperative Relationship between STAT5 and Reactive Oxygen Species in Leukemia: Mechanism and Therapeutic Potential.
Cancers (Basel) Volume: 10
09/27/2018 Authors: Mi T; Wang Z; Bunting KD
Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.
J Biol Chem Volume: 293 Page(s): 9636 - 9650
06/22/2018 Authors: Lee JA; Wang Z; Sambo D; Bunting KD; Pallas DC
Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells.
Sci Rep Volume: 7 Page(s): 4447
06/30/2017 Authors: Metts J; Bradley HL; Wang Z; Shah NP; Kapur R; Arbiser JL; Bunting KD
Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses.
Oncotarget Volume: 8 Page(s): 41876 - 41889
06/27/2017 Authors: Bourgeais J; Ishac N; Medrzycki M; Brachet-Botineau M; Desbourdes L; Gouilleux-Gruart V; Pecnard E; Rouleux-Bonnin F; Gyan E; Domenech J
Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.
Leukemia Volume: 31 Page(s): 1415 - 1422
06/01/2017 Authors: Liu W; Yu W-M; Zhang J; Chan RJ; Loh ML; Zhang Z; Bunting KD; Qu C-K
Stat5 deficiency decreases transcriptional heterogeneity and supports emergence of hematopoietic sub-populations.
Oncotarget Volume: 8 Page(s): 22477 - 22482
04/04/2017 Authors: Wang Z; Bunting KD
Targeting MYC Dependence by Metabolic Inhibitors in Cancer.
Genes (Basel) Volume: 8
03/31/2017 Authors: Sabnis HS; Somasagara RR; Bunting KD
Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine.
Leuk Res Volume: 50 Page(s): 132 - 140
11/01/2016 Authors: Sabnis HS; Bradley HL; Tripathi S; Yu W-M; Tse W; Qu C-K; Bunting KD
MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling.
Oncotarget Volume: 7 Page(s): 43960 - 43973
07/12/2016 Authors: Park J; Kim S; Joh J; Remick SC; Miller DM; Yan J; Kanaan Z; Chao J-H; Krem MM; Basu SK
STAT5 activation in B-cell acute lymphoblastic leukemia: damned if you do, damned if you don't.
Cancer Cell Microenviron Volume: 3
01/01/2016 Authors: Wang Z; Bunting KD
Imipramine Blue Sensitively and Selectively Targets FLT3 and c-Kit Mutant Acute Myeloid Leukemia
Volume: 126
12/03/2015 Authors: Metts JL; Bradley HL; Shah NP; Kapur R; Arbiser JL; Bunting KD
Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis.
Oncotarget Volume: 6 Page(s): 28961 - 28972
10/06/2015 Authors: Wang Z; Medrzycki M; Bunting ST; Bunting KD
AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis.
Oncotarget Volume: 6 Page(s): 20697 - 20710
08/21/2015 Authors: Park J; Schlederer M; Schreiber M; Ice R; Merkel O; Bilban M; Hofbauer S; Kim S; Addison J; Zou J
A novel IL-25 signaling pathway through STAT5.
J Immunol Volume: 194 Page(s): 4528 - 4534
05/01/2015 Authors: Wu L; Zepp JA; Qian W; Martin BN; Ouyang W; Yin W; Bunting KD; Aronica M; Erzurum S; Li X
Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism.
Blood Volume: 125 Page(s): 1562 - 1565
03/05/2015 Authors: Liu X; Zheng H; Yu W-M; Cooper TM; Bunting KD; Qu C-K
Critical Role of Stat5 in the Maintenance of Leukemic Stem Cells in Ptpn11-Associated Juvenile Myelomonocytic Leukemia
Volume: 124
12/06/2014 Authors: Liu W; Liu X; Yu W-M; Bunting KD; Qu C-K
Dysregulated Macrophage Pro-Inflammatory Cytokine Production and Chronic Colitis in Mice Lacking Both Gab2 and Gab3
Volume: 124
12/06/2014 Authors: Vaughan-Whitley TY; Nishio H; Imhoff B; Wang Z; Bunting ST; Hankey-Giblin P; Nusrat A; Parkos CA; Bunting KD
Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.
Cell Rep Volume: 9 Page(s): 1333 - 1348
11/20/2014 Authors: Chatterjee A; Ghosh J; Ramdas B; Mali RS; Martin H; Kobayashi M; Vemula S; Canela VH; Waskow ER; Visconte V
Capillary nano-immunoassay for Akt 1/2/3 and 4EBP1 phosphorylation in acute myeloid leukemia.
J Transl Med Volume: 12 Page(s): 166
06/12/2014 Authors: Sabnis H; Bradley HL; Bunting ST; Cooper TM; Bunting KD
Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence.
Blood Volume: 123 Page(s): 1002 - 1011
02/13/2014 Authors: Qing Y; Wang Z; Bunting KD; Gerson SL
Hematopoietic Stem Cell Protocols Third Edition Preface
Volume: 1185 Page(s): V - V
01/01/2014 Authors: Bunting KD; Qu C-K
STAT5 N-domain deleted isoforms are naturally occurring hypomorphs partially rescued in hematopoiesis by transgenic Bcl-2 expression.
Am J Blood Res Volume: 4 Page(s): 20 - 26
01/01/2014 Authors: Wang Z; Li G; Bunting KD
The hematopoietic stem cell landscape.
Methods Mol Biol Volume: 1185 Page(s): 3 - 6
01/01/2014 Authors: Bunting KD; Qu C-K
Nanoproteomic assays on hematopoietic stem cells.
Methods Mol Biol Volume: 1185 Page(s): 165 - 177
01/01/2014 Authors: Bradley HL; Sabnis H; Pritchett D; Bunting KD
Rapid nano-immunoassay for evaluation of mTOR pathway activation in acute myeloid leukemia.
MOLECULAR CANCER THERAPEUTICS Volume: 12
11/01/2013 Authors: Sabnis H; Bradley H; Cooper T; Bunting K
Genotype-dependent effects of TGF-1 on mast cell function: targeting the Stat5 pathway.
J Immunol Volume: 191 Page(s): 4505 - 4513
11/01/2013 Authors: Fernando J; Faber TW; Pullen NA; Falanga YT; Kolawole EM; Oskeritzian CA; Barnstein BO; Bandara G; Li G; Schwartz LB
STAT5 in hematopoietic stem cell biology and transplantation.
JAKSTAT Volume: 2 Page(s): e27159
10/01/2013 Authors: Wang Z; Bunting KD
Deletion of Gab adaptor proteins leads to impaired macrophage development and chronic colitis
Volume: 190
05/01/2013 Authors: Vaughan T; Imhoff B; Wang Z; Denning T; Bunting K
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90.
Nat Immunol Volume: 14 Page(s): 72 - 81
01/01/2013 Authors: Wang C; Wu L; Bulek K; Martin BN; Zepp JA; Kang Z; Liu C; Herjan T; Misra S; Carman JA
Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT.
Blood Volume: 120 Page(s): 2669 - 2678
09/27/2012 Authors: Mali RS; Ma P; Zeng L-F; Martin H; Ramdas B; He Y; Sims E; Nabinger S; Ghosh J; Sharma N
Mutation of STAT1/3 binding sites in gp130(FXXQ) knock-in mice does not alter hematopoietic stem cell repopulation or self-renewal potential.
Am J Stem Cells Volume: 1 Page(s): 146 - 153
06/30/2012 Authors: Wang Z; Kang Z; Zhang Y; Tse W; Bunting KD
Th17 related cytokines in acute myeloid leukemia.
Front Biosci (Landmark Ed) Volume: 17 Page(s): 2284 - 2294
06/01/2012 Authors: Li P; Ji M; Park J; Bunting KD; Ji C; Tse W
HIF-1 deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency.
Blood Volume: 119 Page(s): 2789 - 2798
03/22/2012 Authors: Du J; Chen Y; Li Q; Han X; Cheng C; Wang Z; Danielpour D; Dunwoodie SL; Bunting KD; Yang Y-C
Novel mechanism for Fc{epsilon}RI-mediated signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation and the selective influence of STAT5B over mast cell cytokine production.
J Biol Chem Volume: 287 Page(s): 2045 - 2054
01/13/2012 Authors: Pullen NA; Barnstein BO; Falanga YT; Wang Z; Suzuki R; Tamang TDL; Khurana MC; Harry EA; Draber P; Bunting KD
Gab adapter proteins as therapeutic targets for hematologic disease.
Adv Hematol Volume: 2012 Page(s): 380635
01/01/2012 Authors: Verma S; Vaughan T; Bunting KD
Molecular targets for the treatment of juvenile myelomonocytic leukemia.
Adv Hematol Volume: 2012 Page(s): 308252
01/01/2012 Authors: Liu X; Sabnis H; Bunting KD; Qu C-K
Launching of american journal of stem cells.
Am J Stem Cells Volume: 1 Page(s): 1
01/01/2012 Authors: Bunting KD; Slukvin I; Wu P; McDonald JW; Wang D
American Journal of Stem Cells: Editorial Board (2012) e-Century Publishing Corporation.
Am J Stem Cells Volume: 1 Page(s): 90 - 91
01/01/2012 Authors: Bunting KD; Wu P; Slukvin I; McDonald JW
Molecular-targeted therapies for hematologic malignancies.
Adv Hematol Volume: 2012 Page(s): 606423
01/01/2012 Authors: Bunting KD; Qu C-K; Tomasson MH
KIT Induced Myeloproliferative Disease Is Dependent on PI3Kinase and SHP2 Phosphatase: Identification of SHP2 As a Druggable Target for Treating MPD and AML
Volume: 118 Page(s): 396 - 396
11/18/2011 Authors: Ma P; Mali R; Zeng L-F; Martin H; Ramdas B; He Y; Sims E; Ghosh J; Nabinger SC; Li S
Generation of a Transgenic Mouse with Inducible Constitutively Active Stat5a
Volume: 118 Page(s): 1456 - 1456
11/18/2011 Authors: Nivarthi H; Tsyrulnyk A; Warsch W; Wang Z; Winkler S; Kenner L; Mueller M; Baum C; Bunting KD; Sexl V
Cited2 Regulates Hematopoietic Stem Cell Quiescence Through HIF-1 alpha Dependent and Independent Pathways
Volume: 118 Page(s): 416 - 417
11/18/2011 Authors: Du J; Chen Y; Li Q; Wang Z; Dunwoodie S; Bunting KD; Yang Y-C
STAT5 Has Tumor Suppressor-Like Activity in a Murine Model of Myc-Initiated Acute B-Lymphoblastic Leukemia/Lymphoma
Volume: 118 Page(s): 419 - 419
11/18/2011 Authors: Wang Z; Li G; Kang Z; Bunting ST; Tse W; Bunting KD
Multiple apoptotic defects in hematopoietic cells from mice lacking lipocalin 24p3.
J Biol Chem Volume: 286 Page(s): 20606 - 20614
06/10/2011 Authors: Liu Z; Yang A; Wang Z; Bunting KD; Davuluri G; Green MR; Devireddy LR
MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML.
Br J Haematol Volume: 153 Page(s): 753 - 757
06/01/2011 Authors: Xiong Y; Li Z; Ji M; Tan A-C; Bemis J; Tse J-V; Huang G; Park J; Ji C; Chen J
Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation.
Front Biosci (Landmark Ed) Volume: 16 Page(s): 3043 - 3056
06/01/2011 Authors: Friedbichler K; Hoelbl A; Li G; Bunting KD; Sexl V; Gouilleux F; Moriggl R
Grb2-associated binding (Gab) proteins in hematopoietic and immune cell biology.
Am J Blood Res Volume: 1 Page(s): 130 - 134
01/01/2011 Authors: Vaughan TY; Verma S; Bunting KD
Multiple Apoptotic Defects In Hematopoietic Cellsfrom Mice Lacking Lipocalin 24p3
Volume: 116 Page(s): 662 - 662
11/19/2010 Authors: Devireddy LR; Liu Z; Ciocea A; Yang A; Wang Z; Bunting KD; Green M
A germline gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells.
Blood Volume: 116 Page(s): 3611 - 3621
11/04/2010 Authors: Xu D; Wang S; Yu W-M; Chan G; Araki T; Bunting KD; Neel BG; Qu C-K
Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation.
Blood Volume: 116 Page(s): 1548 - 1558
09/02/2010 Authors: Friedbichler K; Kerenyi MA; Kovacic B; Li G; Hoelbl A; Yahiaoui S; Sexl V; Mllner EW; Fajmann S; Cerny-Reiterer S
Another Lnk to STAT activation.
Blood Volume: 116 Page(s): 862 - 864
08/12/2010 Authors: Bunting KD
Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin.
Leukemia Volume: 24 Page(s): 1397 - 1405
08/01/2010 Authors: Li G; Miskimen KL; Wang Z; Xie XY; Tse W; Gouilleux F; Moriggl R; Bunting KD
Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained.
Cancer Res Volume: 70 Page(s): 3526 - 3536
05/01/2010 Authors: Ko JS; Rayman P; Ireland J; Swaidani S; Li G; Bunting KD; Rini B; Finke JH; Cohen PA
STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.
Blood Volume: 115 Page(s): 1416 - 1424
02/18/2010 Authors: Li G; Miskimen KL; Wang Z; Xie XY; Brenzovich J; Ryan JJ; Tse W; Moriggl R; Bunting KD
Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.
PLoS One Volume: 5 Page(s): e9152
02/10/2010 Authors: Li G; Wang Z; Miskimen KL; Zhang Y; Tse W; Bunting KD
The AML Prognostic Marker, AF1q, Is Directly Regulated by MiR-29b
Volume: 114 Page(s): 1021 - 1022
11/20/2009 Authors: Xiong Y; Li Z; Tan AC; Bemis J; Xie X; Bunting KD; Chen J; Bemis L; Tse W
Regulation of Hematopoietic Stem Cell Quiescence by Ku70.
Volume: 114 Page(s): 1397 - 1397
11/20/2009 Authors: Qing Y; Wang Z; Liu M; Bunting KD; Gerson SL
STAT5 Requires the N-Domain for Suppression of miR15/16, Induction of Bcl-2, and Survival Signaling in Myeloproliferative Disease
Volume: 114 Page(s): 92 - 93
11/20/2009 Authors: Li G; Miskimen KL; Wang Z; Xie XY; Brenzovich J; Ryan JJ; Tse W; Moriggl R; Bunting KD
Genetic and Pharmacologic Targeting of STAT5/Gab2/PI3K/mTOR Signaling in a Mouse Myeloproliferative Disease Model
Volume: 114 Page(s): 1501 - 1501
11/20/2009 Authors: Li G; Wang Z; Miskimen KL; Xie XY; Tse W; Gouilleux F; Moriggl R; Bunting KD
Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.
Blood Volume: 113 Page(s): 4856 - 4865
05/14/2009 Authors: Wang Z; Li G; Tse W; Bunting KD
Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics.
Am J Hematol Volume: 84 Page(s): 308 - 309
05/01/2009 Authors: Strunk CJ; Platzbecker U; Thiede C; Schaich M; Illmer T; Kang Z; Leahy P; Li C; Xie X; Laughlin MJ
IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen.
J Immunol Volume: 182 Page(s): 2835 - 2841
03/01/2009 Authors: Ohmori K; Luo Y; Jia Y; Nishida J; Wang Z; Bunting KD; Wang D; Huang H
An ENU-induced recessive mutation in Mpl leads to thrombocytopenia with overdominance.
Exp Hematol Volume: 37 Page(s): 276 - 284
02/01/2009 Authors: Chan ER; Lavender H; Li G; Haviernik P; Bunting KD; Adams MD
CLPs find their inner T-cell potential.
Blood Volume: 113 Page(s): 766 - 767
01/22/2009 Authors: Bunting KD
STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells.
Blood Volume: 112 Page(s): 1832 - 1843
09/01/2008 Authors: Cohen PA; Koski GK; Czerniecki BJ; Bunting KD; Fu X-Y; Wang Z; Zhang W-J; Carter CS; Awad M; Distel CA
New insights into cord blood stem cell transplantation.
Curr Opin Hematol Volume: 15 Page(s): 279 - 284
07/01/2008 Authors: Tse W; Bunting KD; Laughlin MJ
Identification of 6-benzylthioinosine as a myeloid leukemia differentiation-inducing compound.
Cancer Res Volume: 68 Page(s): 4369 - 4376
06/01/2008 Authors: Wald DN; Vermaat HM; Zang S; Lavik A; Kang Z; Peleg G; Gerson SL; Bunting KD; Agarwal ML; Roth BL
Umbilical cord blood transplantation in adult myeloid leukemia.
Bone Marrow Transplant Volume: 41 Page(s): 465 - 472
03/01/2008 Authors: Tse WW; Zang SL; Bunting KD; Laughlin MJ
The expanding tool kit for hematopoietic stem cell research.
Methods Mol Biol Volume: 430 Page(s): 3 - 18
01/01/2008 Authors: Tse W; Bunting KD
Hematopoietic stem cell transplant into non-myeloablated W/Wv mice to detect steady-state engraftment defects.
Methods Mol Biol Volume: 430 Page(s): 171 - 181
01/01/2008 Authors: Wang Z; Bunting KD
Retroviral transduction of murine hematopoietic stem cells.
Methods Mol Biol Volume: 430 Page(s): 229 - 241
01/01/2008 Authors: Haviernik P; Zhang Y; Bunting KD
Hematopoiesis in mice is extremely resilient to wide variation in TIMP/MMP balance.
Blood Cells Mol Dis Volume: 41 Page(s): 179 - 187
01/01/2008 Authors: Haviernik P; Diaz MT; Haviernikova E; Tse W; Stetler-Stevenson WG; Bunting KD
Identification and characterization of 6-benzylthioinosine as a novel myeloid differentiation-inducing compound
Volume: 110 Page(s): 276A - 276A
11/16/2007 Authors: Wald DN; Vermaat H; Kang Z; Gerson SL; Bunting KD; Tse W
Physiologically significant genetic interaction between STAT5 and Gab2 during normal and pathologic hematopoiesis
Volume: 110 Page(s): 34A - 35A
11/16/2007 Authors: Li G; Wang Z; Zhang Y; Haviemikova E; Tse W; Bunting KD
Conditional deletion of STAT5 in non-myeloablated recipient mice promotes donor hematopoietic stem cell engraftment
Volume: 110 Page(s): 60A - 60A
11/16/2007 Authors: Wang Z; Li G; Haviernikova E; Tse W; Bunting KD
STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.
Exp Hematol Volume: 35 Page(s): 1684 - 1694
11/01/2007 Authors: Li G; Wang Z; Zhang Y; Kang Z; Haviernikova E; Cui Y; Hennighausen L; Moriggl R; Wang D; Tse W
Cited2 is required for normal hematopoiesis in the murine fetal liver.
Blood Volume: 110 Page(s): 2889 - 2898
10/15/2007 Authors: Chen Y; Haviernik P; Bunting KD; Yang Y-C
Cytoplasmic localization of phosphorylated STAT5 in human acute myeloid leukemia is inversely correlated with Flt3-ITD.
Blood Volume: 110 Page(s): 2775 - 2776
10/01/2007 Authors: Bunting KD; Xie XY; Warshawsky I; Hsi ED
Stat5 is essential for early B cell development but not for B cell maturation and function.
J Immunol Volume: 179 Page(s): 1068 - 1079
07/15/2007 Authors: Dai X; Chen Y; Di L; Podd A; Li G; Bunting KD; Hennighausen L; Wen R; Wang D
Abnormal hematopoiesis in Gab2 mutant mice.
Blood Volume: 110 Page(s): 116 - 124
07/01/2007 Authors: Zhang Y; Diaz-Flores E; Li G; Wang Z; Kang Z; Haviernikova E; Rowe S; Qu C-K; Tse W; Shannon KM
STAT5 signaling in normal and pathologic hematopoiesis.
Front Biosci Volume: 12 Page(s): 2807 - 2820
05/01/2007 Authors: Bunting KD
Hematopoietic reconstitution with androgenetic and gynogenetic stem cells.
Genes Dev Volume: 21 Page(s): 409 - 419
02/15/2007 Authors: Eckardt S; Leu NA; Bradley HL; Kato H; Bunting KD; McLaughlin KJ
Complex systems biology approach to understanding coordination of JAK-STAT signaling.
Biosystems Volume: 90 Page(s): 830 - 842
01/01/2007 Authors: Soebiyanto RP; Sreenath SN; Qu C-K; Loparo KA; Bunting KD
Two mouse genetic models of thrombocytopenia.
Volume: 108 Page(s): 329A - 330A
11/16/2006 Authors: Chan ER; Lavender H; Trevarthen K; Haviernik P; Bunting KD; Adams MD
Stat5 expression is required for IgE-mediated mast cell function.
J Immunol Volume: 177 Page(s): 3421 - 3426
09/01/2006 Authors: Barnstein BO; Li G; Wang Z; Kennedy S; Chalfant C; Nakajima H; Bunting KD; Ryan JJ
Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on interleukin-3 signaling.
J Biol Chem Volume: 281 Page(s): 5426 - 5434
03/03/2006 Authors: Yu W-M; Daino H; Chen J; Bunting KD; Qu C-K
Bone marrow transplantation combined with gene therapy to induce antigen-specific tolerance and ameliorate EAE.
Mol Ther Volume: 13 Page(s): 42 - 48
01/01/2006 Authors: Xu B; Haviernik P; Wolfraim LA; Bunting KD; Scott DW
Effects of a leukemia-associated gain-of-function mutation of SHP-2 phosphatase on IL-3 signaling.
Volume: 106 Page(s): 643A - 643A
11/16/2005 Authors: Yu WM; Daino H; Chen J; Bunting KD; Qu CK
AF1q is a novel poor prognostic marker for adult acute myelogenous leukemia (AML) patients with normal cytogenetics
Volume: 106 Page(s): 921A - 921A
11/16/2005 Authors: Strunk CJ; Platzbecker U; Thiede C; Schaich MA; Illmer T; Kang ZZ; Leahy P; Li CB; Reiner S; Laughlin MJ
Naturally occuring N-terminal truncated STAT5 isoforms are widely expressed, functional, and have enhanced nuclear localization.
Volume: 106 Page(s): 645A - 645A
11/16/2005 Authors: Li GQ; Couldrey C; Moriggl R; Tse W; Bunting KD
Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.
Blood Volume: 105 Page(s): 4235 - 4246
06/01/2005 Authors: Modlich U; Kustikova OS; Schmidt M; Rudolph C; Meyer J; Li Z; Kamino K; von Neuhoff N; Schlegelberger B; Kuehlcke K
Bone marrow transplantation combined with gene therapy to induce antigen-specific tolerance and ameliorate EAE
Volume: 19 Page(s): A924 - A925
03/04/2005 Authors: Xu BY; Haviernik P; Wolfraim L; Bunting KD; Scott DW
A STAT5 modifier locus on murine chromosome 7 modulates engraftment of hematopoietic stem cells during steady-state hematopoiesis.
Blood Volume: 105 Page(s): 1476 - 1483
02/15/2005 Authors: Couldrey C; Bradley HL; Bunting KD
Stat5 tetramer formation is associated with leukemogenesis.
Cancer Cell Volume: 7 Page(s): 87 - 99
01/01/2005 Authors: Moriggl R; Sexl V; Kenner L; Duntsch C; Stangl K; Gingras S; Hoffmeyer A; Bauer A; Piekorz R; Wang D
Tissue inhibitor of matrix metalloproteinase-1 overexpression in M1 myeloblasts impairs IL-6-induced differentiation.
Oncogene Volume: 23 Page(s): 9212 - 9219
12/09/2004 Authors: Haviernik P; Lahoda C; Bradley HL; Hawley TS; Ramezani A; Hawley RG; Stetler-Stevenson M; Stetler-Stevenson WG; Bunting KD
Endogenous N-terminal truncated STAT5 expressed from alternative start codons promotes SCF signaling in murine primary mast cell cultures.
Volume: 104 Page(s): 233A - 233A
11/16/2004 Authors: Bunting KD; Couldrey C; Moriggl R; Cui YZ; Wright H; Wang DM; Ryan JJ; Ihle JN; Hennighausen L
XLA gene therapy turns a corner
BLOOD Volume: 104 Page(s): 1236 - 1236
09/01/2004 Authors: Bunting KD
Safety concerns related to hematopoietic stem cell gene transfer using retroviral vectors.
Curr Gene Ther Volume: 4 Page(s): 263 - 276
09/01/2004 Authors: Haviernik P; Bunting KD
Cutting edge: IL-5 primes Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism.
J Immunol Volume: 173 Page(s): 2918 - 2922
09/01/2004 Authors: Zhu Y; Chen L; Huang Z; Alkan S; Bunting KD; Wen R; Wang D; Huang H
Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression.
J Leukoc Biol Volume: 76 Page(s): 484 - 490
08/01/2004 Authors: Bunting KD; Yu W-M; Bradley HL; Haviernikova E; Kelly-Welch AE; Keegan AD; Qu C-K
A negative role of SHP-2 tyrosine phosphatase in growth factor-dependent hematopoietic cell survival.
Oncogene Volume: 23 Page(s): 3659 - 3669
04/29/2004 Authors: Chen J; Yu W-M; Bunting KD; Qu C-K
Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness.
Blood Volume: 103 Page(s): 2965 - 2972
04/15/2004 Authors: Bradley HL; Couldrey C; Bunting KD
Integrative molecular and developmental biology of adult stem cells.
Biol Cell Volume: 95 Page(s): 563 - 578
12/01/2003 Authors: Bunting KD; Hawley RG
Reproducible insertional leukemogenesis with evidence for chromosomal instability following dose-escalated retroviral vector transfer into murine hematopoietic cells.
Volume: 102 Page(s): 200A - 200A
11/16/2003 Authors: Modlich U; Meyer J; Rudolph C; Knoess S; Kuehlcke K; Li ZX; Bunting KD; von Neuhoff N; Schlegelberger B; von Kalle C
STAT5 is required in a dose-dependent manner and acts synergistically with a modifier locus on murine chromosome 7 for engraftment of hematopoietic stem cells during steady-state hematopoiesis.
Volume: 102 Page(s): 210A - 211A
11/16/2003 Authors: Bunting KD; Couldrey C; Bradley HL
Stat5 expression is critical for mast cell development and survival.
Blood Volume: 102 Page(s): 1290 - 1297
08/15/2003 Authors: Shelburne CP; McCoy ME; Piekorz R; Sexl V; Roh K-H; Jacobs-Helber SM; Gillespie SR; Bailey DP; Mirmonsef P; Mann MN
Comparison with c-Mpl and c-kit mutants and identification of a genetic modifier locus that modulates the severity of hematopoietic stem cell dysfunction in mice lacking expression of STAT5
Volume: 7 Page(s): S108 - S109
05/01/2003 Authors: Bradley HL; Couldrey C; Bunting KD
Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.
Blood Volume: 100 Page(s): 3983 - 3989
12/01/2002 Authors: Bradley HL; Hawley TS; Bunting KD
Autocrine inhibition of M1 myeloid differentiation by constitutive expression of tissue inhibitor of matrix metalloproteinase-1.
Volume: 100 Page(s): 734A - 735A
11/16/2002 Authors: Bradley HL; Hawley TS; Ramezani A; Stetler-Stevenson WG; Stetler-Stevenson M; Hawley RG; Bunting KD
The levels or expression of AF1q influence the degree of differentiation of different myeloid leukemia cell lines.
Volume: 100 Page(s): 166B - 167B
11/16/2002 Authors: Tae WW; Bradley HL; Kussick S; Banker DE; Radich J; Collins SL; Bunting KD; Appelbaum FR
Cell intrinsic defects in hematopoietic stem cells from STAT5ab(-/-) mice due to reduced proliferation in response to early-acting cytokines.
BLOOD CELLS MOLECULES AND DISEASES Volume: 28 Page(s): 326 - 326
05/01/2002 Authors: Bunting KD; Hawley TS; Bradley HL
The tao of hematopoietic stem cells: toward a unified theory of tissue regeneration.
ScientificWorldJournal Volume: 2 Page(s): 983 - 995
04/10/2002 Authors: Bunting KD; Hawley RG
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.
Blood Volume: 99 Page(s): 479 - 487
01/15/2002 Authors: Bunting KD; Bradley HL; Hawley TS; Moriggl R; Sorrentino BP; Ihle JN
ABC transporters as phenotypic markers and functional regulators of stem cells.
Stem Cells Volume: 20 Page(s): 11 - 20
01/01/2002 Authors: Bunting KD
A cell intrinsic requirement for STAT5 activation in hematopoietic stem cells.
BLOOD Volume: 98 Page(s): 452A - 452A
11/16/2001 Authors: Bunting KD; Bradley HL; Hawley TS; Morrigl R; Sorrentino BP; Ihle JN
Enforced expression of the novel MLL-associated gene, AF1q, increases the percentage of undifferentiated M1 myeloid leukemia cells.
BLOOD Volume: 98 Page(s): 800A - 800A
11/16/2001 Authors: Tse WW; Bradley HL; Hawley TS; Minden M; Iscove N; Appelbaum FR; Bunting KD
The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype.
Nat Med Volume: 7 Page(s): 1028 - 1034
09/01/2001 Authors: Zhou S; Schuetz JD; Bunting KD; Colapietro AM; Sampath J; Morris JJ; Lagutina I; Grosveld GC; Osawa M; Nakauchi H
Selective protection by stably transfected human ALDH3A1 (but not human ALDH1A1) against toxicity of aliphatic aldehydes in V79 cells.
Chem Biol Interact Volume: 130-132 Page(s): 261 - 273
01/30/2001 Authors: Townsend AJ; Leone-Kabler S; Haynes RL; Wu Y; Szweda L; Bunting KD
Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development.
Mol Cell Biol Volume: 21 Page(s): 678 - 689
01/01/2001 Authors: Wen R; Wang D; McKay C; Bunting KD; Marine JC; Vanin EF; Zambetti GP; Korsmeyer SJ; Ihle JN; Cleveland JL
Self-selection by genetically modified committed lymphocyte precursors reverses the phenotype of JAK3-deficient mice without myeloablation.
Hum Gene Ther Volume: 11 Page(s): 2353 - 2364
11/20/2000 Authors: Bunting KD; Lu T; Kelly PF; Sorrentino BP
Expression of the breast cancer resistance protein (BCRP) in side population (SP) stem cells, natural killer (NK) lymphocytes, and erythroid progenitor cells.
BLOOD Volume: 96 Page(s): 820A - 820A
11/16/2000 Authors: Zhou S; Morris JJ; Bunting KD; Osawa M; Schuetz JD; Nakauchi H; Sorrentino BP
The ATP-binding cassette transporter gene, ABCG2, is expressed in murine side population (SP) hematopoietic stem cells and promotes SP cell expansion in vitro.
BLOOD CELLS MOLECULES AND DISEASES Volume: 26 Page(s): 532 - 532
10/01/2000 Authors: Zhou S; Morris JJ; Bunting KD; Schuetz JD; Sorrentino BP
A role for ABC transporter expression in normal and leukemic hematopoiesis.
BLOOD CELLS MOLECULES AND DISEASES Volume: 26 Page(s): 504 - 504
10/01/2000 Authors: Zhou S; Bunting KD; Schuetz JD; Osawa M; Nakauchi H; Sorrentino BP
Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5.
Blood Volume: 96 Page(s): 2277 - 2283
09/15/2000 Authors: Sexl V; Piekorz R; Moriggl R; Rohrer J; Brown MP; Bunting KD; Rothammer K; Roussel MF; Ihle JN
Enforced P-glycoprotein pump function in murine bone marrow cells results in expansion of side population stem cells in vitro and repopulating cells in vivo.
Blood Volume: 96 Page(s): 902 - 909
08/01/2000 Authors: Bunting KD; Zhou S; Lu T; Sorrentino BP
Effects of retroviral-mediated MDR1 expression on hematopoietic stem cell self-renewal and differentiation in culture.
Volume: 872 Page(s): 125 - 140
04/30/1999 Authors: Bunting KD; Galipeau J; Topham D; Benaim E; Sorrentino BP
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
Immunity Volume: 10 Page(s): 249 - 259
02/01/1999 Authors: Moriggl R; Topham DJ; Teglund S; Sexl V; McKay C; Wang D; Hoffmeyer A; van Deursen J; Sangster MY; Bunting KD
Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency.
Proc Natl Acad Sci U S A Volume: 96 Page(s): 232 - 237
01/05/1999 Authors: Bunting KD; Flynn KJ; Riberdy JM; Doherty PC; Sorrentino BP
JAK3 gene therapy in non-myeloablated neonatal mice provides long-term correction of T lymphocyte and, to a lesser degree, B lymphocyte numbers.
BLOOD Volume: 92 Page(s): 667A - 667A
11/15/1998 Authors: Bunting K; Sangster M; Kelly P; Sorrentino BP
Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice.
Blood Volume: 92 Page(s): 2269 - 2279
10/01/1998 Authors: Bunting KD; Galipeau J; Topham D; Benaim E; Sorrentino BP
Dependence of aldehyde dehydrogenase-mediated oxazaphosphorine resistance on soluble thiols: importance of thiol interactions with the secondary metabolite acrolein.
Biochem Pharmacol Volume: 56 Page(s): 31 - 39
07/01/1998 Authors: Bunting KD; Townsend AJ
Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer.
Nat Med Volume: 4 Page(s): 58 - 64
01/01/1998 Authors: Bunting KD; Sangster MY; Ihle JN; Sorrentino BP
Restored lymphocyte function in janus kinase 3-deficient mice by retroviral-mediated gene transfer.
BLOOD Volume: 90 Page(s): 1152 - 1152
11/15/1997 Authors: Bunting K; Sangster M; Ihle J; Sorrentino B
Coding region-specific destabilization of mRNA transcripts attenuates expression from retroviral vectors containing class 1 aldehyde dehydrogenase cDNAs.
Hum Gene Ther Volume: 8 Page(s): 1531 - 1543
09/01/1997 Authors: Bunting KD; Webb M; Giorgianni F; Galipeau J; Blakley RL; Townsend AJ; Sorrentino BP
In vivo restoration of lymphoid function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer.
EXPERIMENTAL HEMATOLOGY Volume: 25 Page(s): 12 - 12
08/01/1997 Authors: Bunting K; Sangster M; Ihle J; Sorrentino B
De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.
J Biol Chem Volume: 271 Page(s): 11884 - 11890
05/17/1996 Authors: Bunting KD; Townsend AJ
Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effects of oxazaphosphorine alkylating agents in hamster V79 cell lines. Demonstration of aldophosphamide metabolism by the human cytosolic class 3 isozyme.
J Biol Chem Volume: 271 Page(s): 11891 - 11896
05/17/1996 Authors: Bunting KD; Townsend AJ
Oxazaphosphorine-specific resistance in human MCF-7 breast carcinoma cell lines expressing transfected rat class 3 aldehyde dehydrogenase.
J Biol Chem Volume: 269 Page(s): 23197 - 23203
09/16/1994 Authors: Bunting KD; Lindahl R; Townsend AJ

Directory section navigation

Profile

Kevin Bunting PhD

Academic Appointment

Education

Degrees

Research

Focus

Publications