School of Medicine Homepage
Emory University Shield
  • About
    • Our Vision
    • Academic Departments
    • Our Leadership
    • Health Care Partnerships
    • Diversity, Equity, & Inclusion
    • Location
    • Supporting Our People
    • Our Faculty
    • History
    • News
    • Events
    • Contact Us
  • Education
    • Degree and Certificate Programs
    • Academic Departments
    • Residents & Fellows
    • Postdoctoral Training
    • Continuing Medical Education
    • Admissions
    • Cost and Financial Aid
    • Student Resources
  • Research
    • Research Innovation
    • Conducting Research
    • Core Facilities
    • Research Centers
    • Research Training
    • Academic Departments
    • Find a Researcher
    • Research News
  • Clinical Experience
    • Where We Work
    • Caring for a Diverse Population
    • Faculty Clinical Experience
    • Advanced Patient Care
    • Academic Departments
    • Community Learning
  • Giving
  • Directory

Directory section navigation

  • Faculty Profiles

Emory University School of Medicine

  • About
    • Sub link
      Our Vision
    • Sub link
      Academic Departments
    • Sub link
      Our Leadership
    • Sub link
      Health Care Partnerships
    • Sub link
      Diversity, Equity, & Inclusion
    • Sub link
      Location
    • Sub link
      Supporting Our People
    • Sub link
      Our Faculty
    • Sub link
      History
    • Sub link
      News
    • Sub link
      Events
    • Sub link
      Contact Us
  • Education
    • Sub link
      Degree and Certificate Programs
    • Sub link
      Academic Departments
    • Sub link
      Residents & Fellows
    • Sub link
      Postdoctoral Training
    • Sub link
      Continuing Medical Education
    • Sub link
      Admissions
    • Sub link
      Cost and Financial Aid
    • Sub link
      Student Resources
  • Research
    • Sub link
      Research Innovation
    • Sub link
      Conducting Research
    • Sub link
      Core Facilities
    • Sub link
      Research Centers
    • Sub link
      Research Training
    • Sub link
      Academic Departments
    • Sub link
      Find a Researcher
    • Sub link
      Research News
  • Clinical Experience
    • Sub link
      Where We Work
    • Sub link
      Caring for a Diverse Population
    • Sub link
      Faculty Clinical Experience
    • Sub link
      Advanced Patient Care
    • Sub link
      Academic Departments
    • Sub link
      Community Learning
  • Giving
  • Directory
  • Home School of Medicine Home
  • Directory

Profile

Karmella Haynes

  • Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory
    Assistant Professor
  • karmella.ann.haynes@emory.edu
  • LinkedIn - Karmella Haynes-Ferrell
  • Haynes Lab at Emory
Head shot of Karmella Haynes

Academic Appointment

  • Associate Professor, Wallace H. Coulter Department of Biomedical Engineering, Emory University

Education

Degrees

  • PhD from Washington University in St. Louis
  • BS from Florida A&M University - Florida State University College of Engineering

Research

Publications

  • Ten Years of the Synthetic Biology Summer Course at Cold Spring Harbor Laboratory.
    ACS Synth Biol Volume: 13 Page(s): 2635 - 2642
    09/20/2024 Authors: Haynes KA; Andrews LB; Beisel CL; Chappell J; Cuba Samaniego CE; Dueber JE; Dunlop MJ; Franco E; Lucks JB; Noireaux V
  • The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces.

    02/02/2024 Authors: Kellner AV; Hunter R; Do P; Eggert J; Jaffe M; Geitgey DK; Lee M; Hamilton JAG; Ross AJ; Ank RS
  • The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity.
    Adv Exp Med Biol Volume: 1465 Page(s): 37 - 53
    01/01/2024 Authors: Townsel A; Jaffe M; Wu Y; Henry CJ; Haynes KA
  • Reader-Effectors as Actuators of Epigenome Editing.
    Methods Mol Biol Volume: 2842 Page(s): 103 - 127
    01/01/2024 Authors: Kim SH; Haynes KA
  • Synthetic Reader-Actuators Targeted to Polycomb-Silenced Genes Block Triple-Negative Breast Cancer Proliferation and Invasion.
    GEN Biotechnol Volume: 2 Page(s): 301 - 316
    08/01/2023 Authors: Hong L; Williams NL; Jaffe M; Shields CE; Haynes KA
  • The 'omics of obesity in B-cell acute lymphoblastic leukemia.
    J Natl Cancer Inst Monogr Volume: 2023 Page(s): 12 - 29
    05/04/2023 Authors: Geitgey DK; Lee M; Cottrill KA; Jaffe M; Pilcher W; Bhasin S; Randall J; Ross AJ; Salemi M; Castillo-Castrejon M
  • Adding post-translational modifications and protein-protein interactions to protein schematics.
    Trends Biochem Sci Volume: 48 Page(s): 407 - 409
    05/01/2023 Authors: Pandey N; Franklin KA; Haynes KA; Rap M; Cristea IM
  • PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasion.
    bioRxiv
    01/23/2023 Authors: Williams NL; Hong L; Jaffe M; Shields CE; Haynes KA
  • Rapid Single-Pot Assembly of Modular Chromatin Proteins for Epigenetic Engineering.
    Methods Mol Biol Volume: 2599 Page(s): 191 - 214
    01/01/2023 Authors: Haynes KA; Priode JH
  • The sound of silence: Transgene silencing in mammalian cell engineering.
    Cell Syst Volume: 13 Page(s): 950 - 973
    12/21/2022 Authors: Cabrera A; Edelstein HI; Glykofrydis F; Love KS; Palacios S; Tycko J; Zhang M; Lensch S; Shields CE; Livingston M
  • B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12.
    Sci Rep Volume: 12 Page(s): 11870
    07/13/2022 Authors: Hunter R; Imbach KJ; Zhou C; Dougan J; Hamilton JAG; Chen KZ; Do P; Townsel A; Gibson G; Dreaden EC
  • Beyond the marks: reader-effectors as drivers of epigenetics and chromatin engineering.
    Trends Biochem Sci Volume: 47 Page(s): 417 - 432
    05/01/2022 Authors: Franklin KA; Shields CE; Haynes KA
  • The living interface between synthetic biology and biomaterial design.
    Nat Mater Volume: 21 Page(s): 390 - 397
    04/01/2022 Authors: Liu AP; Appel EA; Ashby PD; Baker BM; Franco E; Gu L; Haynes K; Joshi NS; Kloxin AM; Kouwer PHJ
  • Adipocyte-mediated epigenomic instability in human T-ALL cells is cytotoxic and phenocopied by epigenetic-modifying drugs.
    Front Cell Dev Biol Volume: 10 Page(s): 909557
    01/01/2022 Authors: Lee M; Geitgey DK; Hamilton JAG; Boss JM; Scharer CD; Spangle JM; Haynes KA; Henry CJ
  • Epigenetic regulator BMI1 promotes alveolar rhabdomyosarcoma proliferation and constitutes a novel therapeutic target.
    Mol Oncol Volume: 15 Page(s): 2156 - 2171
    08/01/2021 Authors: Shields CE; Potlapalli S; Cuya-Smith SM; Chappell SK; Chen D; Martinez D; Pogoriler J; Rathi KS; Patel SA; Oristian KM
  • Fund Black scientists.
    Cell Volume: 184 Page(s): 561 - 565
    02/04/2021 Authors: Stevens KR; Masters KS; Imoukhuede PI; Haynes KA; Setton LA; Cosgriff-Hernandez E; Lediju Bell MA; Rangamani P; Sakiyama-Elbert SE; Finley SD
  • How Has the COVID-19 Pandemic Changed How You Will Approach Research and Lab Work in the Future?
    Cell Syst Volume: 11 Page(s): 550 - 554
    12/16/2020 Authors: Haynes K; Yau C; Bild A; Laughney A; Morsut L; Yang X; Zaugg J; Hsu P; Pancaldi V; Iyer-Biswas S
  • Site-directed targeting of transcriptional activation-associated proteins to repressed chromatin restores CRISPR activity.
    APL Bioeng Volume: 4 Page(s): 016102
    03/01/2020 Authors: Daer R; Hamna F; Barrett CM; Haynes KA
  • Components from the Human c-myb Transcriptional Regulation System Reactivate Epigenetically Repressed Transgenes.
    Int J Mol Sci Volume: 21
    01/14/2020 Authors: Barrett CM; McCracken R; Elmer J; Haynes KA
  • Chromatin engineering offers an opportunity to advance epigenetic cancer therapy.
    Nat Struct Mol Biol Volume: 26 Page(s): 842 - 845
    10/01/2019 Authors: Baskin NL; Haynes KA
  • Engineered Orthogonal Quorum Sensing Systems for Synthetic Gene Regulation in Escherichia coli.
    Front Bioeng Biotechnol Volume: 7 Page(s): 80
    01/01/2019 Authors: Tekel SJ; Smith CL; Lopez B; Mani A; Connot C; Livingstone X; Haynes KA
  • An inhibitor screen identifies histone-modifying enzymes as mediators of polymer-mediated transgene expression from plasmid DNA.
    J Control Release Volume: 286 Page(s): 210 - 223
    09/28/2018 Authors: Christensen MD; Nitiyanandan R; Meraji S; Daer R; Godeshala S; Goklany S; Haynes K; Rege K
  • The synthetic histone-binding regulator protein PcTF activates interferon genes in breast cancer cells.
    BMC Syst Biol Volume: 12 Page(s): 83
    09/25/2018 Authors: Olney KC; Nyer DB; Vargas DA; Wilson Sayres MA; Haynes KA
  • Design, Construction, and Validation of Histone-Binding Effectors in Vitro and in Cells.
    Biochemistry Volume: 57 Page(s): 4707 - 4716
    08/07/2018 Authors: Tekel SJ; Barrett C; Vargas D; Haynes KA
  • Tandem Histone-Binding Domains Enhance the Activity of a Synthetic Chromatin Effector.
    ACS Synth Biol Volume: 7 Page(s): 842 - 852
    03/16/2018 Authors: Tekel SJ; Vargas DA; Song L; LaBaer J; Caplan MR; Haynes KA
  • Characterization of diverse homoserine lactone synthases in Escherichia coli.
    PLoS One Volume: 13 Page(s): e0202294
    01/01/2018 Authors: Daer R; Barrett CM; Melendez EL; Wu J; Tekel SJ; Xu J; Dennison B; Muller R; Haynes KA
  • Molecular structures guide the engineering of chromatin.
    Nucleic Acids Res Volume: 45 Page(s): 7555 - 7570
    07/27/2017 Authors: Tekel SJ; Haynes KA
  • The Impact of Chromatin Dynamics on Cas9-Mediated Genome Editing in Human Cells.
    ACS Synth Biol Volume: 6 Page(s): 428 - 438
    03/17/2017 Authors: Daer RM; Cutts JP; Brafman DA; Haynes KA
  • Regulation of cancer epigenomes with a histone-binding synthetic transcription factor.
    NPJ Genom Med Volume: 2
    01/01/2017 Authors: Nyer DB; Daer RM; Vargas D; Hom C; Haynes KA
  • The histone deacetylase inhibitor Entinostat enhances polymer-mediated transgene expression in cancer cell lines.
    Biotechnol Bioeng Volume: 113 Page(s): 1345 - 1356
    06/01/2016 Authors: Elmer JJ; Christensen MD; Barua S; Lehrman J; Haynes KA; Rege K
  • Synthetic biology: Building genetic containment.
    Nat Chem Biol Volume: 12 Page(s): 55 - 56
    02/01/2016 Authors: Haynes KA
  • Corrigendum: Can the Natural Diversity of Quorum-Sensing Advance Synthetic Biology?
    Front Bioeng Biotechnol Volume: 3 Page(s): 99
    01/01/2015 Authors: Davis RM; Muller RY; Haynes KA
  • Can the natural diversity of quorum-sensing advance synthetic biology?
    Front Bioeng Biotechnol Volume: 3 Page(s): 30
    01/01/2015 Authors: Davis RM; Muller RY; Haynes KA
  • Editorial - Synthetic Biology: Engineering Complexity and Refactoring Cell Capabilities.
    Front Bioeng Biotechnol Volume: 3 Page(s): 120
    01/01/2015 Authors: Ceroni F; Carbonell P; Franois J-M; Haynes KA
  • Preparing synthetic biology for the world.
    Front Microbiol Volume: 4 Page(s): 5
    01/01/2013 Authors: Moe-Behrens GHG; Davis R; Haynes KA
  • A BioBrick compatible strategy for genetic modification of plants.
    J Biol Eng Volume: 6 Page(s): 8
    06/20/2012 Authors: Boyle PM; Burrill DR; Inniss MC; Agapakis CM; Deardon A; DeWerd JG; Gedeon MA; Quinn JY; Paull ML; Raman AM
  • A sensitive switch for visualizing natural gene silencing in single cells.
    ACS Synth Biol Volume: 1 Page(s): 99 - 106
    03/16/2012 Authors: Haynes KA; Ceroni F; Flicker D; Younger A; Silver PA
  • Synthetic reversal of epigenetic silencing.
    J Biol Chem Volume: 286 Page(s): 27176 - 27182
    08/05/2011 Authors: Haynes KA; Silver PA
  • Eukaryotic systems broaden the scope of synthetic biology.
    J Cell Biol Volume: 187 Page(s): 589 - 596
    11/30/2009 Authors: Haynes KA; Silver PA
  • Engineering bacteria to solve the Burnt Pancake Problem.
    J Biol Eng Volume: 2 Page(s): 8
    05/20/2008 Authors: Haynes KA; Broderick ML; Brown AD; Butner TL; Dickson JO; Harden WL; Heard LH; Jessen EL; Malloy KJ; Ogden BJ
  • An investigation of heterochromatin domains on the fourth chromosome of Drosophila melanogaster.
    Genetics Volume: 178 Page(s): 1177 - 1191
    03/01/2008 Authors: Riddle NC; Leung W; Haynes KA; Granok H; Wuller J; Elgin SCR
  • A Distinct type of heterochromatin within Drosophila melanogaster chromosome 4.
    Genetics Volume: 175 Page(s): 1539 - 1542
    03/01/2007 Authors: Haynes KA; Gracheva E; Elgin SCR
  • Element 1360 and RNAi components contribute to HP1-dependent silencing of a pericentric reporter.
    Curr Biol Volume: 16 Page(s): 2222 - 2227
    11/21/2006 Authors: Haynes KA; Caudy AA; Collins L; Elgin SCR
  • cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four.
    Mol Cell Biol Volume: 24 Page(s): 8210 - 8220
    09/01/2004 Authors: Sun F-L; Haynes K; Simpson CL; Lee SD; Collins L; Wuller J; Eissenberg JC; Elgin SCR
  • Analyzing heterochromatin formation using chromosome 4 of Drosophila melanogaster.
    Volume: 69 Page(s): 267 - 272
    01/01/2004 Authors: Haynes KA; Leibovitch BA; Rangwala SH; Craig C; Elgin SCR
Read more publications Fewer publications
Directory
  • Faculty Profiles
Emory University Homepage

Contact & Location

Emory University School of Medicine
100 Woodruff Circle
Atlanta, GA  30322 USA
  • Contact Us
  • Maps & Directions
  • Careers

Information For

  • Alumni
  • Faculty & Staff
  • Patients
  • Residents & Fellows
  • Students
Support the School of Medicine School of Medicine Intranet
facebook facebook twitter twitter linkedin linkedin instagram instagram youtube youtube
© 2025 Emory University
  • Privacy Policy
  • Emergency Information
  • EEO Employer-Disability/Veteran Statements